succinylacetone has been researched along with Liver Diseases in 6 studies
succinylacetone: inhibitor of heme biosynthesis
4,6-dioxoheptanoic acid : A dioxo monocarboxylic acid that is heptanoic acid in which oxo groups replace the hydrogens at positions 4 and 6. It is an abnormal metabolite of the tyrosine metabolic pathway and a marker for type 1 tyrosinaemia.
Liver Diseases: Pathological processes of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hepatorenal tyrosinemia (HT1) is considered a treatable inherited metabolic disease, particularly when detected early in life." | 1.33 | Quantification of succinylacetone in urine of hepatorenal tyrosinemia patients by HPLC with fluorescence detection. ( Al-Ahaidib, LY; Al-Dirbashi, OY; Al-Owain, M; Al-Qahtani, K; Jacob, M; Rahbeeni, Z; Rashed, MS, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alvarez, F | 1 |
| Atkinson, S | 1 |
| Bouchard, M | 1 |
| Brunel-Guitton, C | 1 |
| Buhas, D | 1 |
| Bussières, JF | 1 |
| Dubois, J | 1 |
| Fenyves, D | 1 |
| Goodyer, P | 1 |
| Gosselin, M | 1 |
| Halac, U | 1 |
| Labbé, P | 1 |
| Laframboise, R | 1 |
| Maranda, B | 1 |
| Melançon, S | 1 |
| Merouani, A | 1 |
| Mitchell, GA | 1 |
| Mitchell, J | 1 |
| Parizeault, G | 1 |
| Pelletier, L | 1 |
| Phan, V | 1 |
| Turcotte, JF | 1 |
| Peake, RW | 1 |
| Al-Dirbashi, OY | 2 |
| Fisher, L | 1 |
| McRoberts, C | 1 |
| Siriwardena, K | 1 |
| Geraghty, M | 1 |
| Chakraborty, P | 1 |
| Jacob, M | 1 |
| Al-Ahaidib, LY | 1 |
| Al-Qahtani, K | 1 |
| Rahbeeni, Z | 1 |
| Al-Owain, M | 1 |
| Rashed, MS | 1 |
| Grompe, M | 1 |
| Lindstedt, S | 1 |
| al-Dhalimy, M | 1 |
| Kennaway, NG | 1 |
| Papaconstantinou, J | 1 |
| Torres-Ramos, CA | 1 |
| Ou, CN | 1 |
| Finegold, M | 1 |
| Kvittingen, EA | 1 |
| Jellum, E | 1 |
| Stokke, O | 1 |
| Flatmark, A | 1 |
| Bergan, A | 1 |
| Sødal, G | 1 |
| Halvorsen, S | 1 |
| Schrumpf, E | 1 |
| Gjone, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacotoxicology of Trichloroethylene Metabolites: Short-term Effect of DCA on in Vivo Tyrosine Catabolism and MAAI Expression[NCT00865514] | 2 participants (Actual) | Interventional | 2011-08-31 | Terminated (stopped due to Difficulty in obtaining the solution from the compounding pharmacies caused a two year delay in start-up; the funding ended prior to study completion.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for succinylacetone and Liver Diseases
| Article | Year |
|---|---|
The Québec NTBC Study.
Topics: Cyclohexanones; Enzyme Inhibitors; Heptanoates; Humans; Infant, Newborn; Liver Diseases; Liver Trans | 2017 |
5 other studies available for succinylacetone and Liver Diseases
| Article | Year |
|---|---|
Deranged Liver Function in a Neonate.
Topics: Biomarkers; Cyclohexanones; Enzyme Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Heptano | 2016 |
Identification of a neonate with hepatorenal tyrosinemia by combined routine newborn screening for succinylacetone, acylcarnitines and amino acids.
Topics: Amino Acids; Carnitine; Heptanoates; Humans; Infant, Newborn; Kidney Diseases; Liver Diseases; Neona | 2010 |
Quantification of succinylacetone in urine of hepatorenal tyrosinemia patients by HPLC with fluorescence detection.
Topics: Calibration; Chromatography, High Pressure Liquid; Heptanoates; Humans; Kidney Diseases; Liver Disea | 2006 |
Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I.
Topics: alpha-Fetoproteins; Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Cyclohexanones; Dise | 1995 |
Liver transplantation in a 23-year-old tyrosinaemia patient: effects on the renal tubular dysfunction.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Amino Acids; beta 2-Microglobulin; Female; Glycosuria; | 1986 |