succinylacetone has been researched along with Leucocythaemia in 1 studies
succinylacetone: inhibitor of heme biosynthesis
4,6-dioxoheptanoic acid : A dioxo monocarboxylic acid that is heptanoic acid in which oxo groups replace the hydrogens at positions 4 and 6. It is an abnormal metabolite of the tyrosine metabolic pathway and a marker for type 1 tyrosinaemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| " These data show a dose-response increase in HPRT-Mf in HL-60 cells treated with SA, suggesting that this chemical causes mutations in the HPRT locus in these cells either directly or indirectly through its inhibition of the MPO activity." | 5.33 | Increased mutant frequencies in the HPRT gene locus of leukemia HL-60 cells treated with succinylacetone. ( Kagan, VE; Keohavong, P; Yalowich, JC; Zheng, KC, 2006) |
| " These data show a dose-response increase in HPRT-Mf in HL-60 cells treated with SA, suggesting that this chemical causes mutations in the HPRT locus in these cells either directly or indirectly through its inhibition of the MPO activity." | 1.33 | Increased mutant frequencies in the HPRT gene locus of leukemia HL-60 cells treated with succinylacetone. ( Kagan, VE; Keohavong, P; Yalowich, JC; Zheng, KC, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zheng, KC | 1 |
| Yalowich, JC | 1 |
| Kagan, VE | 1 |
| Keohavong, P | 1 |
1 other study available for succinylacetone and Leucocythaemia
| Article | Year |
|---|---|
Increased mutant frequencies in the HPRT gene locus of leukemia HL-60 cells treated with succinylacetone.
Topics: Cell Survival; Heptanoates; HL-60 Cells; Humans; Hypoxanthine Phosphoribosyltransferase; Leukemia; M | 2006 |