succinylacetone has been researched along with Graft vs Host Disease in 4 studies
succinylacetone: inhibitor of heme biosynthesis
4,6-dioxoheptanoic acid : A dioxo monocarboxylic acid that is heptanoic acid in which oxo groups replace the hydrogens at positions 4 and 6. It is an abnormal metabolite of the tyrosine metabolic pathway and a marker for type 1 tyrosinaemia.
Graft vs Host Disease: The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " bioavailability was ca." | 1.29 | Suppression of graft-versus-host disease by succinyl acetone in a rat allogeneic bone marrow transplantation model. ( Bauer, R; Chang, TQ; Fidler, JM; Vitt, CR; Young, JD, 1993) |
| "Succinylacetone is a seven-carbon organic ketoacid that we have previously shown to inhibit tumor allograft rejection as well as the primary antibody response to sheep erythrocytes in rats." | 1.27 | Immunosuppression by succinylacetone. II. Prevention of graft-vs-host disease. ( Blaese, RM; Hess, RA; Tschudy, DP, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fidler, JM | 3 |
| Chang, TQ | 1 |
| Bauer, R | 1 |
| Young, JD | 1 |
| Vitt, CR | 1 |
| Raff, RF | 2 |
| Storb, R | 2 |
| Graham, T | 2 |
| Sale, GE | 1 |
| Johnston, B | 1 |
| Deeg, HJ | 2 |
| Pepe, M | 2 |
| Schuening, F | 2 |
| Appelbaum, FR | 2 |
| Sale, G | 1 |
| Shulman, H | 1 |
| Hess, RA | 1 |
| Tschudy, DP | 1 |
| Blaese, RM | 1 |
4 other studies available for succinylacetone and Graft vs Host Disease
| Article | Year |
|---|---|
Suppression of graft-versus-host disease by succinyl acetone in a rat allogeneic bone marrow transplantation model.
Topics: Animals; Bone Marrow Transplantation; Dose-Response Relationship, Drug; Female; Graft vs Host Diseas | 1993 |
Pharmacologic, toxicologic, and marrow transplantation studies in dogs given succinyl acetone.
Topics: Animals; Bone Marrow Transplantation; Dogs; Female; Graft Rejection; Graft vs Host Disease; Haploidy | 1992 |
Succinyl acetone plus methotrexate as graft-versus-host disease prophylaxis in DLA-haploidentical canine littermate marrow grafts.
Topics: Animals; Bone Marrow Transplantation; Dogs; Drug Therapy, Combination; Graft Survival; Graft vs Host | 1992 |
Immunosuppression by succinylacetone. II. Prevention of graft-vs-host disease.
Topics: Animals; Bone Marrow Transplantation; Cell Survival; Chimera; Graft vs Host Disease; Graft vs Host R | 1987 |