succinylacetone has been researched along with Disease Models, Animal in 9 studies
succinylacetone: inhibitor of heme biosynthesis
4,6-dioxoheptanoic acid : A dioxo monocarboxylic acid that is heptanoic acid in which oxo groups replace the hydrogens at positions 4 and 6. It is an abnormal metabolite of the tyrosine metabolic pathway and a marker for type 1 tyrosinaemia.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "1." | 1.28 | Physiological basis for an animal model of the renal Fanconi syndrome: use of succinylacetone in the rat. ( Boynton, SB; Chu, J; Roth, KS; Spencer, RF; Wyss, PA, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blackburn, PR | 1 |
| Hickey, RD | 1 |
| Nace, RA | 1 |
| Giama, NH | 1 |
| Kraft, DL | 1 |
| Bordner, AJ | 1 |
| Chaiteerakij, R | 1 |
| McCormick, JB | 1 |
| Radulovic, M | 1 |
| Graham, RP | 1 |
| Torbenson, MS | 1 |
| Tortorelli, S | 1 |
| Scott, CR | 1 |
| Lindor, NM | 1 |
| Milliner, DS | 1 |
| Oglesbee, D | 1 |
| Al-Qabandi, W | 1 |
| Grompe, M | 2 |
| Gavrilov, DK | 1 |
| El-Youssef, M | 1 |
| Clark, KJ | 1 |
| Atwal, PS | 1 |
| Roberts, LR | 1 |
| Klee, EW | 1 |
| Ekker, SC | 1 |
| Lindstedt, S | 1 |
| al-Dhalimy, M | 1 |
| Kennaway, NG | 1 |
| Papaconstantinou, J | 1 |
| Torres-Ramos, CA | 1 |
| Ou, CN | 1 |
| Finegold, M | 1 |
| Garrick, MD | 1 |
| Scott, D | 1 |
| Kulju, D | 1 |
| Romano, MA | 1 |
| Dolan, KG | 1 |
| Garrick, LM | 1 |
| Wyss, PA | 1 |
| Boynton, SB | 1 |
| Chu, J | 1 |
| Spencer, RF | 2 |
| Roth, KS | 5 |
| Collins, JC | 1 |
| Buchanan, DN | 1 |
| Thoene, JG | 1 |
| Erickson, RP | 1 |
| Brooks, SS | 1 |
| Gluecksohn-Waelsch, S | 1 |
| Carter, BE | 1 |
| Higgins, ES | 2 |
| Medow, MS | 1 |
| Moses, LC | 1 |
| Spencer, PD | 2 |
| Schwarz, SM | 1 |
| Foreman, JW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacotoxicology of Trichloroethylene Metabolites: Short-term Effect of DCA on in Vivo Tyrosine Catabolism and MAAI Expression[NCT00865514] | 2 participants (Actual) | Interventional | 2011-08-31 | Terminated (stopped due to Difficulty in obtaining the solution from the compounding pharmacies caused a two year delay in start-up; the funding ended prior to study completion.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for succinylacetone and Disease Models, Animal
| Article | Year |
|---|---|
Human renal Fanconi syndrome--then and now.
Topics: Animals; Cystinosis; Disease Models, Animal; Dogs; Fanconi Syndrome; Heptanoates; Humans; Maleates | 1989 |
8 other studies available for succinylacetone and Disease Models, Animal
| Article | Year |
|---|---|
Silent Tyrosinemia Type I Without Elevated Tyrosine or Succinylacetone Associated with Liver Cirrhosis and Hepatocellular Carcinoma.
Topics: Adolescent; Animals; Carcinoma, Hepatocellular; Catalytic Domain; Cell Line, Tumor; Child; Child, Pr | 2016 |
Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I.
Topics: alpha-Fetoproteins; Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Cyclohexanones; Dise | 1995 |
Evidence for and consequences of chronic heme deficiency in Belgrade rat reticulocytes.
Topics: Anemia, Hypochromic; Animals; Cell-Free System; Cycloheximide; Disease Models, Animal; Heme; Heptano | 1999 |
Physiological basis for an animal model of the renal Fanconi syndrome: use of succinylacetone in the rat.
Topics: Amino Acids; Animals; Creatinine; Disease Models, Animal; Fanconi Syndrome; Glucose; Heptanoates; Ki | 1992 |
Metabolic studies in a mouse model of hepatorenal tyrosinemia: absence of perinatal abnormalities.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Animals, Newborn; Chromosome Deletion; Disease Models | 1992 |
Succinylacetone effects on renal tubular phosphate metabolism: a model for experimental renal Fanconi syndrome.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Disease Models, Animal; Fanconi Syndrome; Glutamat | 1991 |
Renal Fanconi syndrome: developmental basis for a new animal model with relevance to human disease.
Topics: Amino Acids; Animals; Animals, Newborn; Biological Transport; Carbohydrate Metabolism; Disease Model | 1989 |
Effects of succinylacetone on methyl alpha-D-glucoside uptake by the rat renal tubule.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Fanconi Syndrome; Heptanoates; Heptanoic Ac | 1985 |