succinylacetone has been researched along with Di Guglielmo Disease in 16 studies
succinylacetone: inhibitor of heme biosynthesis
4,6-dioxoheptanoic acid : A dioxo monocarboxylic acid that is heptanoic acid in which oxo groups replace the hydrogens at positions 4 and 6. It is an abnormal metabolite of the tyrosine metabolic pathway and a marker for type 1 tyrosinaemia.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (50.00) | 18.7374 |
| 1990's | 6 (37.50) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tahara, T | 1 |
| Sun, J | 1 |
| Nakanishi, K | 1 |
| Yamamoto, M | 2 |
| Mori, H | 1 |
| Saito, T | 1 |
| Fujita, H | 3 |
| Igarashi, K | 1 |
| Taketani, S | 2 |
| Chang, CS | 1 |
| Sassa, S | 4 |
| Beaumont, C | 3 |
| Deybach, JC | 1 |
| Grandchamp, B | 3 |
| da Silva, V | 1 |
| de Verneuil, H | 3 |
| Nordmann, Y | 3 |
| Ebert, PS | 2 |
| Frykholm, BC | 2 |
| Hess, RA | 2 |
| Tschudy, DP | 2 |
| Fukuda, Y | 1 |
| Kawasaki, N | 1 |
| Morimoto, K | 1 |
| Tanimoto, T | 1 |
| Hayakawa, T | 1 |
| Hafid-Medheb, K | 1 |
| Poindessous-Jazat, V | 1 |
| Augery-Bourget, Y | 1 |
| Hanania, N | 1 |
| Robert-Lézénès, J | 1 |
| Woodard, SI | 1 |
| Dailey, HA | 1 |
| Hradilek, A | 1 |
| Fuchs, O | 1 |
| Neuwirt, J | 1 |
| Yamagami, T | 1 |
| Hayashi, N | 1 |
| Battistini, A | 1 |
| Coccia, EM | 1 |
| Marziali, G | 1 |
| Bulgarini, D | 1 |
| Scalzo, S | 1 |
| Fiorucci, G | 1 |
| Romeo, G | 1 |
| Affabris, E | 1 |
| Testa, U | 1 |
| Rossi, GB | 1 |
| Bottomley, SS | 1 |
| Wolfe, LC | 1 |
| Bridges, KR | 1 |
| Elferink, CJ | 1 |
| May, BK | 1 |
| Bogard, M | 1 |
16 other studies available for succinylacetone and Di Guglielmo Disease
| Article | Year |
|---|---|
Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells.
Topics: Animals; Basic-Leucine Zipper Transcription Factors; Binding Sites; Blotting, Northern; Cell Line; C | 2004 |
Induction of delta-aminolevulinic acid dehydratase in mouse Friend virus-transformed erythroleukemia cells during erythroid differentiation.
Topics: Animals; Bromodeoxyuridine; Cell Differentiation; Cross Reactions; Dimethyl Sulfoxide; Drug Antagoni | 1984 |
Effects of succinylacetone on dimethylsulfoxide-mediated induction of heme pathway enzymes in mouse friend virus-transformed erythroleukemia cells.
Topics: 5-Aminolevulinate Synthetase; Animals; Cell Transformation, Viral; Cells, Cultured; Dimethyl Sulfoxi | 1984 |
Uptake of hematin and growth of malignant murine erythroleukemia cells depleted of endogenous heme by succinylacetone.
Topics: 5-Aminolevulinate Synthetase; Animals; Biological Transport; Cell Division; Heme; Hemin; Heptanoates | 1981 |
Dimethyl sulphoxide and haemin induce ferrochelatase mRNA by different mechanisms in murine erythroleukaemia cells.
Topics: Animals; Dimethyl Sulfoxide; Ferrochelatase; Hemin; Heptanoates; Leukemia, Erythroblastic, Acute; Mi | 1993 |
Control of hemoglobin synthesis in erythroid differentiating K562 cells. I. Role of iron in erythroid cell heme synthesis.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Butyrates; Butyric Acid; Cell Differentiation; Ce | 1996 |
Bcl-XL induction during terminal differentiation of friend erythroleukaemia cells correlates with delay of apoptosis and loss of proliferative capacity but not with haemoglobinization.
Topics: Acetamides; Animals; Apoptosis; bcl-X Protein; Cell Cycle; Cell Differentiation; Cell Division; Cell | 1999 |
Multiple regulatory steps in erythroid heme biosynthesis.
Topics: Aminolevulinic Acid; Animals; Enzyme Inhibitors; Erythroid Precursor Cells; Erythropoiesis; Heme; He | 2000 |
Succinylacetone, a potent inhibitor of heme biosynthesis: effect on cell growth, heme content and delta-aminolevulinic acid dehydratase activity of malignant murine erythroleukemia cells.
Topics: Animals; Cell Division; Cells, Cultured; Heme; Hemoglobins; Heptanoates; Heptanoic Acids; Keto Acids | 1979 |
Inhibition of heme synthesis decreases transferrin receptor expression in mouse erythroleukemia cells.
Topics: Animals; Gene Expression; Glutathione Peroxidase; Glycine; Heme; Heptanoates; Iron; Leukemia, Erythr | 1992 |
Erythroleukemia differentiation. Distinctive responses of the erythroid-specific and the nonspecific delta-aminolevulinate synthase mRNA.
Topics: 5-Aminolevulinate Synthetase; Animals; Base Sequence; Blotting, Northern; Blotting, Western; Cell Li | 1991 |
Intracellular heme coordinately modulates globin chain synthesis, transferrin receptor number, and ferritin content in differentiating Friend erythroleukemia cells.
Topics: Cell Differentiation; Dimethyl Sulfoxide; Ferritins; Globins; Heme; Heptanoates; Humans; Leukemia, E | 1991 |
Iron metabolism in K562 erythroleukemic cells.
Topics: Cell Line; Deferoxamine; Heme; Heptanoates; Humans; Iron; Leukemia, Erythroblastic, Acute; Receptors | 1985 |
Regulation of 5-aminolevulinate synthase in mouse erythroleukemic cells is different from that in liver.
Topics: 5-Aminolevulinate Synthetase; Animals; Hemin; Heptanoates; Leukemia, Erythroblastic, Acute; Liver; M | 1988 |
Porphobilinogen deaminase is unstable in the absence of its substrate.
Topics: Ammonia-Lyases; Cell Differentiation; Dimethyl Sulfoxide; Fluorometry; Friend murine leukemia virus; | 1986 |
Accumulation of porphobilinogen deaminase, uroporphyrinogen decarboxylase, and alpha- and beta-globin mRNAs during differentiation of mouse erythroleukemic cells. Effects of succinylacetone.
Topics: Ammonia-Lyases; Animals; Carboxy-Lyases; Cell Differentiation; Electrophoresis, Agar Gel; Friend mur | 1985 |