succinylacetone has been researched along with Anemia, Hypochromic in 2 studies
succinylacetone: inhibitor of heme biosynthesis
4,6-dioxoheptanoic acid : A dioxo monocarboxylic acid that is heptanoic acid in which oxo groups replace the hydrogens at positions 4 and 6. It is an abnormal metabolite of the tyrosine metabolic pathway and a marker for type 1 tyrosinaemia.
Anemia, Hypochromic: Anemia characterized by a decrease in the ratio of the weight of hemoglobin to the volume of the erythrocyte, i.e., the mean corpuscular hemoglobin concentration is less than normal. The individual cells contain less hemoglobin than they could have under optimal conditions. Hypochromic anemia may be caused by iron deficiency from a low iron intake, diminished iron absorption, or excessive iron loss. It can also be caused by infections or other diseases, therapeutic drugs, lead poisoning, and other conditions. (Stedman, 25th ed; from Miale, Laboratory Medicine: Hematology, 6th ed, p393)
| Excerpt | Relevance | Reference |
|---|---|---|
| "When succinylacetone is used to inhibit Belgrade heme synthesis, iron from diferric transferrin does not accumulate in the stromal fraction that contains mitochondria, nor does 59Fe accumulate in the nonheme cytosolic fraction." | 1.29 | Iron distribution in Belgrade rat reticulocytes after inhibition of heme synthesis with succinylacetone. ( Cohan, DS; Garrick, LM; Garrick, MD; Gniecko, K; Grasso, JA; Liu, Y, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Garrick, LM | 2 |
| Gniecko, K | 1 |
| Liu, Y | 1 |
| Cohan, DS | 1 |
| Grasso, JA | 1 |
| Garrick, MD | 2 |
| Scott, D | 1 |
| Kulju, D | 1 |
| Romano, MA | 1 |
| Dolan, KG | 1 |
2 other studies available for succinylacetone and Anemia, Hypochromic
| Article | Year |
|---|---|
Iron distribution in Belgrade rat reticulocytes after inhibition of heme synthesis with succinylacetone.
Topics: Anemia, Hypochromic; Animals; Cytosol; Heme; Heptanoates; Iron; Iron Radioisotopes; Mitochondria; Mu | 1993 |
Evidence for and consequences of chronic heme deficiency in Belgrade rat reticulocytes.
Topics: Anemia, Hypochromic; Animals; Cell-Free System; Cycloheximide; Disease Models, Animal; Heme; Heptano | 1999 |