succinic acid has been researched along with Spinocerebellar Ataxias in 2 studies
Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.
Spinocerebellar Ataxias: A group of predominately late-onset, cerebellar ataxias which have been divided into multiple subtypes based on clinical features and genetic mapping. Progressive ataxia is a central feature of these conditions, and in certain subtypes POLYNEUROPATHY; DYSARTHRIA; visual loss; and other disorders may develop. (From Joynt, Clinical Neurology, 1997, Ch65, pp 12-17; J Neuropathol Exp Neurol 1998 Jun;57(6):531-43)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acute treatment of postsymptomatic SCA1 mice with succinic acid, a complex II (succinate dehydrogenase) electron donor to bypass complex I dysfunction, ameliorated cerebellar OXPHOS dysfunction, reduced cerebellar pathology and improved motor behavior." | 1.46 | Short-term succinic acid treatment mitigates cerebellar mitochondrial OXPHOS dysfunction, neurodegeneration and ataxia in a Purkinje-specific spinocerebellar ataxia type 1 (SCA1) mouse model. ( Berry, G; Carbone, E; Ferro, A; Frederick, K; Hartman, J; Ingram, MA; Ives, S; Lagalwar, S; Marzouk, E; Nguyen, D; Polley, K; Possidente, B; Possidente, T; Reynolds, TH; Siegel, A; Villegas, M; Zhang, J, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ferro, A | 2 |
| Carbone, E | 2 |
| Zhang, J | 1 |
| Marzouk, E | 2 |
| Villegas, M | 1 |
| Siegel, A | 2 |
| Nguyen, D | 2 |
| Possidente, T | 1 |
| Hartman, J | 2 |
| Polley, K | 2 |
| Ingram, MA | 1 |
| Berry, G | 1 |
| Reynolds, TH | 1 |
| Possidente, B | 1 |
| Frederick, K | 2 |
| Ives, S | 2 |
| Lagalwar, S | 2 |
2 other studies available for succinic acid and Spinocerebellar Ataxias
| Article | Year |
|---|---|
Short-term succinic acid treatment mitigates cerebellar mitochondrial OXPHOS dysfunction, neurodegeneration and ataxia in a Purkinje-specific spinocerebellar ataxia type 1 (SCA1) mouse model.
Topics: Animals; Cerebellum; Disease Models, Animal; Mice; Mice, Transgenic; Mitochondria; Oxidative Phospho | 2017 |
Treating SCA1 Mice with Water-Soluble Compounds to Non-Specifically Boost Mitochondrial Function.
Topics: Animals; Behavior, Animal; Cerebellum; Chromatography, High Pressure Liquid; Dendrites; Disease Mode | 2017 |