succinic acid has been researched along with Sensitivity and Specificity in 21 studies
Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " This assay has been successfully applied to a pharmacokinetic and tissue distribution study after intravenous injection of ASE in mouse in a dose of 10 mg/kg." | 1.39 | Preclinical pharmacokinetic analysis of armillarisin succinate ester in mouse plasma and tissues by LC-MS/MS. ( Chen, Q; Li, P; Zhang, J; Zhu, J, 2013) |
| "Methylmalonic acid (MMA) is a dicarboxylic acid whose concentration can be increased in blood and urine in patients with an inborn error of metabolism or vitamin B(12) deficiency." | 1.31 | Analysis of dicarboxylic acids by tandem mass spectrometry. High-throughput quantitative measurement of methylmalonic acid in serum, plasma, and urine. ( Komaromy-Hiller, G; Kushnir, MM; Roberts, WL; Shushan, B; Urry, FM, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 12 (57.14) | 29.6817 |
| 2010's | 7 (33.33) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, G | 1 |
| Shen, Q | 1 |
| Zhang, G | 1 |
| Wang, P | 1 |
| Yu, ZG | 1 |
| Richter, S | 1 |
| Peitzsch, M | 1 |
| Rapizzi, E | 1 |
| Lenders, JW | 1 |
| Qin, N | 1 |
| de Cubas, AA | 1 |
| Schiavi, F | 1 |
| Rao, JU | 1 |
| Beuschlein, F | 1 |
| Quinkler, M | 1 |
| Timmers, HJ | 1 |
| Opocher, G | 1 |
| Mannelli, M | 1 |
| Pacak, K | 2 |
| Robledo, M | 1 |
| Eisenhofer, G | 1 |
| Mineva, EM | 1 |
| Zhang, M | 1 |
| Rabinowitz, DJ | 1 |
| Phinney, KW | 1 |
| Pfeiffer, CM | 1 |
| Imperiale, A | 1 |
| Moussallieh, FM | 1 |
| Roche, P | 1 |
| Battini, S | 1 |
| Cicek, AE | 1 |
| Sebag, F | 1 |
| Brunaud, L | 1 |
| Barlier, A | 1 |
| Elbayed, K | 1 |
| Loundou, A | 1 |
| Bachellier, P | 1 |
| Goichot, B | 1 |
| Stratakis, CA | 1 |
| Namer, IJ | 1 |
| Taïeb, D | 1 |
| Yang, S | 1 |
| Sadilek, M | 1 |
| Synovec, RE | 1 |
| Lidstrom, ME | 1 |
| Bardella, C | 1 |
| El-Bahrawy, M | 1 |
| Frizzell, N | 1 |
| Adam, J | 1 |
| Ternette, N | 1 |
| Hatipoglu, E | 1 |
| Howarth, K | 1 |
| O'Flaherty, L | 1 |
| Roberts, I | 1 |
| Turner, G | 1 |
| Taylor, J | 1 |
| Giaslakiotis, K | 1 |
| Macaulay, VM | 1 |
| Harris, AL | 1 |
| Chandra, A | 1 |
| Lehtonen, HJ | 1 |
| Launonen, V | 1 |
| Aaltonen, LA | 1 |
| Pugh, CW | 1 |
| Mihai, R | 1 |
| Trudgian, D | 1 |
| Kessler, B | 1 |
| Baynes, JW | 1 |
| Ratcliffe, PJ | 1 |
| Tomlinson, IP | 1 |
| Pollard, PJ | 1 |
| Chen, Q | 1 |
| Li, P | 1 |
| Zhang, J | 1 |
| Zhu, J | 1 |
| Dong, W | 1 |
| Matsuno, YK | 1 |
| Kameyama, A | 1 |
| Li, X | 1 |
| Wu, F | 1 |
| Beard, DA | 1 |
| Cocchi, M | 1 |
| Lambertini, P | 1 |
| Manzini, D | 1 |
| Marchetti, A | 1 |
| Ulrici, A | 1 |
| Garg, M | 1 |
| Gupta, RK | 1 |
| Husain, M | 1 |
| Chawla, S | 1 |
| Chawla, J | 1 |
| Kumar, R | 1 |
| Rao, SB | 1 |
| Misra, MK | 1 |
| Prasad, KN | 1 |
| Lindström, A | 1 |
| Albertsson, AC | 1 |
| Hakkarainen, M | 1 |
| Zhu, X | 1 |
| Lü, C | 1 |
| Gao, Y | 1 |
| Kushnir, MM | 2 |
| Rockwood, AL | 1 |
| Nelson, GJ | 1 |
| Ritov, VB | 1 |
| Menshikova, EV | 1 |
| Kelley, DE | 1 |
| Brewster, LP | 1 |
| Washington, C | 1 |
| Brey, EM | 1 |
| Gassman, A | 1 |
| Subramanian, A | 1 |
| Calceterra, J | 1 |
| Wolf, W | 1 |
| Hall, CL | 1 |
| Velander, WH | 1 |
| Burgess, WH | 1 |
| Greisler, HP | 1 |
| Chekmenev, EY | 1 |
| Hövener, J | 1 |
| Norton, VA | 1 |
| Harris, K | 1 |
| Batchelder, LS | 1 |
| Bhattacharya, P | 1 |
| Ross, BD | 1 |
| Weitekamp, DP | 1 |
| Klöhn, PC | 1 |
| Neumann, HG | 1 |
| Vejchapipat, P | 1 |
| Williams, SR | 1 |
| Spitz, L | 1 |
| Pierro, A | 1 |
| Komaromy-Hiller, G | 1 |
| Shushan, B | 1 |
| Urry, FM | 1 |
| Roberts, WL | 1 |
| Izco, JM | 1 |
| Tormo, M | 1 |
| Jiménez-Flores, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Muscle Insulin Resistance In Aging[NCT02230839] | 200 participants (Anticipated) | Interventional | 2014-06-30 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
21 other studies available for succinic acid and Sensitivity and Specificity
| Article | Year |
|---|---|
LSTMCNNsucc: A Bidirectional LSTM and CNN-Based Deep Learning Method for Predicting Lysine Succinylation Sites.
Topics: Algorithms; Animals; Area Under Curve; Computational Biology; Deep Learning; Escherichia coli; Human | 2021 |
Krebs cycle metabolite profiling for identification and stratification of pheochromocytomas/paragangliomas due to succinate dehydrogenase deficiency.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Citric Acid Cycle; Female; Follow-Up Studies; Fuma | 2014 |
An LC-MS/MS method for serum methylmalonic acid suitable for monitoring vitamin B12 status in population surveys.
Topics: Anticoagulants; Calibration; Chromatography, Liquid; Chromatography, Reverse-Phase; Gas Chromatograp | 2015 |
Metabolome profiling by HRMAS NMR spectroscopy of pheochromocytomas and paragangliomas detects SDH deficiency: clinical and pathophysiological implications.
Topics: Female; Humans; Immunohistochemistry; Male; Metabolic Networks and Pathways; Metabolome; Metabolomic | 2015 |
Liquid chromatography-tandem quadrupole mass spectrometry and comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry measurement of targeted metabolites of Methylobacterium extorquens AM1 grown on two different carbon sources.
Topics: Carbon; Chromatography, Liquid; Data Interpretation, Statistical; Ethylamines; Gas Chromatography-Ma | 2009 |
Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status.
Topics: Adult; Aged; Animals; Biomarkers, Tumor; Carcinoma, Renal Cell; Disease Models, Animal; Female; Fuma | 2011 |
Preclinical pharmacokinetic analysis of armillarisin succinate ester in mouse plasma and tissues by LC-MS/MS.
Topics: Animals; Benzopyrans; Chromatography, High Pressure Liquid; Drug Stability; Esters; Female; Linear M | 2013 |
A procedure for Alcian blue staining of mucins on polyvinylidene difluoride membranes.
Topics: Alcian Blue; Animals; Membranes, Artificial; Mucins; Periodic Acid-Schiff Reaction; Polysaccharides; | 2012 |
Identification of the kinetic mechanism of succinyl-CoA synthetase.
Topics: Acyl Coenzyme A; Animals; Computer Simulation; Enzyme Stability; Kinetics; Myocardium; Osmolar Conce | 2013 |
Determination of carboxylic acids in vinegars and in Aceto Balsamico Tradizionale di Modena by HPLC and GC methods.
Topics: Acetic Acid; Carboxylic Acids; Chromatography, Gas; Chromatography, High Pressure Liquid; Gluconates | 2002 |
Brain abscesses: etiologic categorization with in vivo proton MR spectroscopy.
Topics: Acetates; Adolescent; Adult; Amino Acids; Analysis of Variance; Bacterial Infections; Bacteriologica | 2004 |
Development of a solid-phase extraction method for simultaneous extraction of adipic acid, succinic acid and 1,4-butanediol formed during hydrolysis of poly(butylene adipate) and poly(butylene succinate).
Topics: Adipates; Butylene Glycols; Gas Chromatography-Mass Spectrometry; Hydrolysis; Molecular Weight; Poly | 2004 |
[Analysis of volatile fragrant components in hawthorn tincture by gas chromatography-mass spectrometry].
Topics: Crataegus; Eugenol; Gas Chromatography-Mass Spectrometry; Hexanols; Oils, Volatile; Plant Extracts; | 2004 |
Simultaneous quantitative analysis of isobars by tandem mass spectrometry from unresolved chromatographic peaks.
Topics: Algorithms; Calibration; Humans; Isomerism; Mass Spectrometry; Methylmalonic Acid; Sensitivity and S | 2004 |
High-performance liquid chromatography-based methods of enzymatic analysis: electron transport chain activity in mitochondria from human skeletal muscle.
Topics: Alamethicin; Chromatography, High Pressure Liquid; Electron Transport; Electron Transport Complex I; | 2004 |
Construction and characterization of a thrombin-resistant designer FGF-based collagen binding domain angiogen.
Topics: Aspirin; Binding Sites; Cells, Cultured; Chemotaxis; Collagen; Drug Combinations; Enzyme Activation; | 2008 |
PASADENA hyperpolarization of succinic acid for MRI and NMR spectroscopy.
Topics: Algorithms; Carbon Isotopes; Deuterium; Hydrogen-Ion Concentration; Magnetic Resonance Imaging; Magn | 2008 |
Impairment of respiration and oxidative phosphorylation by redox cyclers 2-nitrosofluorene and menadione.
Topics: 2,4-Dinitrophenol; Animals; Carcinogens; Coloring Agents; Hydroxyacetylaminofluorene; Male; Mitochon | 1997 |
Intestinal metabolism after ischemia-reperfusion.
Topics: Amino Acids; Analysis of Variance; Animals; Disease Models, Animal; Glucose; Intestine, Small; Ische | 2000 |
Analysis of dicarboxylic acids by tandem mass spectrometry. High-throughput quantitative measurement of methylmalonic acid in serum, plasma, and urine.
Topics: Chromatography, Liquid; Gas Chromatography-Mass Spectrometry; Humans; Methylmalonic Acid; Plasma; Se | 2001 |
Development of a CE method to analyze organic acids in dairy products: application to study the metabolism of heat-shocked spores.
Topics: Acetic Acid; Animals; Butyric Acid; Carboxylic Acids; Citric Acid; Dairy Products; Electrophoresis, | 2002 |