succinic acid has been researched along with Reperfusion Injury in 29 studies
Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Propofol (2,6-diisopropylphenol) has been proven to attenuate mitochondrial dysfunction and reperfusion injury." | 7.88 | Propofol Prevents Oxidative Stress by Decreasing the Ischemic Accumulation of Succinate in Focal Cerebral Ischemia-Reperfusion Injury. ( Gao, D; Jin, W; Liu, S; Qi, S; Yu, W, 2018) |
| " Propofol (2,6-diisopropylphenol) has been proven to attenuate mitochondrial dysfunction and reperfusion injury." | 3.88 | Propofol Prevents Oxidative Stress by Decreasing the Ischemic Accumulation of Succinate in Focal Cerebral Ischemia-Reperfusion Injury. ( Gao, D; Jin, W; Liu, S; Qi, S; Yu, W, 2018) |
| "Current treatments for acute ischemic stroke aim to reinstate a normal perfusion in the ischemic territory but can also cause significant ischemia-reperfusion (IR) injury." | 1.91 | Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke. ( Burger, N; Dannhorn, A; Frezza, C; Goodwin, R; Huang, MM; Krieg, T; Kulaveerasingam, D; Lee, JJ; Mair, R; Mottahedin, A; Murphy, MP; Peruzzotti-Jametti, L; Pluchino, S; Prag, HA; Schmidt, C; Sorby-Adams, A; Yang, M, 2023) |
| "Upon reoxygenation after anoxia the succinate that had accumulated during anoxia was rapidly oxidized in association with extensive mitochondrial superoxide/hydrogen peroxide production and cell injury, mimicking reperfusion injury." | 1.72 | Mitochondrial metabolism and bioenergetic function in an anoxic isolated adult mouse cardiomyocyte model of in vivo cardiac ischemia-reperfusion injury. ( Allen, FM; Bates, GR; Burger, N; Casey, AM; Gruszczyk, AV; Hall, AR; James, AM; Krieg, T; Murphy, MP; Prag, HA; Saeb-Parsy, K, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.45) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (20.69) | 29.6817 |
| 2010's | 12 (41.38) | 24.3611 |
| 2020's | 10 (34.48) | 2.80 |
| Authors | Studies |
|---|---|
| Neimark, MI | 1 |
| Gruszczyk, AV | 3 |
| Casey, AM | 1 |
| James, AM | 4 |
| Prag, HA | 3 |
| Burger, N | 2 |
| Bates, GR | 1 |
| Hall, AR | 1 |
| Allen, FM | 2 |
| Krieg, T | 4 |
| Saeb-Parsy, K | 3 |
| Murphy, MP | 5 |
| Milliken, AS | 2 |
| Nadtochiy, SM | 2 |
| Brookes, PS | 4 |
| Panconesi, R | 1 |
| Widmer, J | 1 |
| Carvalho, MF | 1 |
| Eden, J | 1 |
| Dondossola, D | 1 |
| Dutkowski, P | 1 |
| Schlegel, A | 1 |
| Wang, YH | 1 |
| Yan, ZZ | 1 |
| Luo, SD | 1 |
| Hu, JJ | 1 |
| Wu, M | 3 |
| Zhao, J | 2 |
| Liu, WF | 1 |
| Li, C | 2 |
| Liu, KX | 1 |
| Mottahedin, A | 1 |
| Dannhorn, A | 1 |
| Mair, R | 1 |
| Schmidt, C | 1 |
| Yang, M | 1 |
| Sorby-Adams, A | 1 |
| Lee, JJ | 1 |
| Kulaveerasingam, D | 1 |
| Huang, MM | 2 |
| Pluchino, S | 1 |
| Peruzzotti-Jametti, L | 1 |
| Goodwin, R | 1 |
| Frezza, C | 3 |
| Cao, Z | 1 |
| Mu, S | 1 |
| Wang, M | 1 |
| Zhang, Y | 5 |
| Zou, G | 1 |
| Yuan, X | 1 |
| Huang, Y | 2 |
| Yu, S | 1 |
| Zhang, J | 5 |
| Zhang, C | 1 |
| Oh, CJ | 1 |
| Kim, MJ | 2 |
| Lee, JM | 1 |
| Kim, DH | 1 |
| Kim, IY | 1 |
| Park, S | 2 |
| Kim, Y | 4 |
| Lee, KB | 1 |
| Lee, SH | 1 |
| Lim, CW | 1 |
| Kim, M | 1 |
| Lee, JY | 1 |
| Pagire, HS | 1 |
| Pagire, SH | 1 |
| Bae, MA | 1 |
| Chanda, D | 1 |
| Thoudam, T | 1 |
| Khang, AR | 1 |
| Harris, RA | 1 |
| Ahn, JH | 1 |
| Jeon, JH | 1 |
| Lee, IK | 1 |
| Martin, JL | 1 |
| Costa, ASH | 2 |
| Beach, TE | 1 |
| Hinchy, EC | 1 |
| Mahbubani, K | 1 |
| Hamed, M | 2 |
| Tronci, L | 1 |
| Nikitopoulou, E | 1 |
| Robinson, AJ | 2 |
| Caldwell, ST | 1 |
| Logan, A | 2 |
| Pala, L | 1 |
| Hartley, RC | 2 |
| Nguépy Keubo, FR | 1 |
| Mboua, PC | 1 |
| Djifack Tadongfack, T | 1 |
| Fokouong Tchoffo, E | 1 |
| Tasson Tatang, C | 1 |
| Ide Zeuna, J | 1 |
| Noupoue, EM | 1 |
| Tsoplifack, CB | 1 |
| Folefack, GO | 1 |
| Kettani, M | 1 |
| Bandelier, P | 1 |
| Huo, J | 1 |
| Li, H | 4 |
| Yu, D | 1 |
| Arulsamy, N | 1 |
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| Prakash, J | 1 |
| Buan, MEM | 1 |
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| Chavan, S | 1 |
| Shi, X | 1 |
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| Mainwaring, RD | 1 |
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| Hahn, S | 3 |
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| Ling, J | 2 |
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| Zhao, S | 1 |
| Fan, XH | 1 |
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| Rabiu, KA | 1 |
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| Jin, L | 1 |
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| Zhang, E | 1 |
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| Xue, F | 1 |
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| Wang, Y | 2 |
| Meng, J | 1 |
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| Anastassiadou, M | 1 |
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| Brancato, A | 1 |
| Carrasco Cabrera, L | 1 |
| Greco, L | 1 |
| Jarrah, S | 1 |
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| Leuschner, R | 1 |
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| Rojas, A | 1 |
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| Theobald, A | 1 |
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| Verani, A | 1 |
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| Ren, Y | 1 |
| Li, J | 7 |
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| Liang, C | 1 |
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| Panagiotakos, DB | 1 |
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3 reviews available for succinic acid and Reperfusion Injury
| Article | Year |
|---|---|
[Ischemia-reperfusion syndrome].
Topics: Humans; Ischemia; Reperfusion; Reperfusion Injury; Succinic Acid | 2021 |
Mitochondria and ischemia reperfusion injury.
Topics: Humans; Inflammation; Ischemia; Mitochondria; Reperfusion Injury; Succinic Acid | 2022 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
1 trial available for succinic acid and Reperfusion Injury
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
26 other studies available for succinic acid and Reperfusion Injury
| Article | Year |
|---|---|
Mitochondrial metabolism and bioenergetic function in an anoxic isolated adult mouse cardiomyocyte model of in vivo cardiac ischemia-reperfusion injury.
Topics: Animals; Disease Models, Animal; Energy Metabolism; Hypoxia; Ischemia; Lactates; Mice; Myocytes, Car | 2022 |
Inhibiting Succinate Release Worsens Cardiac Reperfusion Injury by Enhancing Mitochondrial Reactive Oxygen Species Generation.
Topics: Animals; Ischemia; Mice; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondri | 2022 |
Gut microbiota-derived succinate aggravates acute lung injury after intestinal ischaemia/reperfusion in mice.
Topics: Acute Lung Injury; Animals; Gastrointestinal Microbiome; Ischemia; Mice; Mice, Inbred C57BL; Phospha | 2023 |
Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke.
Topics: Animals; Brain Injuries; Brain Ischemia; Humans; Ischemia; Ischemic Stroke; Mice; Reperfusion Injury | 2023 |
Succinate pretreatment attenuates intestinal ischemia-reperfusion injury by inhibiting necroptosis and inflammation via upregulating Klf4.
Topics: Animals; Inflammation; Intestines; Kruppel-Like Factor 4; Mice; Necroptosis; Rats; Reperfusion Injur | 2023 |
Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving mitochondrial function during reperfusion.
Topics: Animals; Ischemia; Kidney; Mice; Mice, Knockout; Mitochondria; Reactive Oxygen Species; Reperfusion; | 2023 |
Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation.
Topics: Animals; Humans; Mice; Organ Transplantation; Reperfusion Injury; Succinic Acid; Swine | 2019 |
Amber alert: getting to the heart of succinate efflux in reperfusion injury.
Topics: Amber; Heart; Humans; Reperfusion Injury; Succinic Acid | 2021 |
Letter in response to "the role of succinate and ROS in reperfusion injury - A critical appraisal" by Andrienko et al.
Topics: Humans; Reactive Oxygen Species; Reperfusion Injury; Succinates; Succinic Acid | 2017 |
Propofol Prevents Oxidative Stress by Decreasing the Ischemic Accumulation of Succinate in Focal Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Brain Ischemia; Ischemia; Male; Membrane Potential, Mitochondrial; Mitochondria; Neuroprote | 2018 |
Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity.
Topics: Animals; Aspartic Acid; Autophagy; Citric Acid Cycle; Electron Transport Complex II; Energy Metaboli | 2018 |
Selective organ ischaemia/reperfusion identifies liver as the key driver of the post-injury plasma metabolome derangements.
Topics: Animals; Liver; Male; Metabolome; Oxidation-Reduction; Reperfusion Injury; Succinic Acid; Swine | 2019 |
Metabolic adaptations during extreme anoxia in the turtle heart and their implications for ischemia-reperfusion injury.
Topics: Animals; Heart; Hypoxia; Myocardium; Reactive Oxygen Species; Reperfusion Injury; Succinic Acid; Tur | 2019 |
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.
Topics: Adenosine Monophosphate; Animals; Aspartic Acid; Citric Acid Cycle; Disease Models, Animal; Electron | 2014 |
Biochemistry: succinate strikes.
Topics: Animals; Ischemia; Male; Mitochondria; Reactive Oxygen Species; Reperfusion Injury; Succinic Acid | 2014 |
Mitochondrial metabolomics unravel the primordial trigger of ischemia/reperfusion injury.
Topics: Animals; Ischemia; Male; Mitochondria; Reactive Oxygen Species; Reperfusion Injury; Succinic Acid | 2015 |
Succinate: A Promising Therapeutic Target for Reperfusion Injury.
Topics: Animals; Ischemia; Male; Mitochondria; Reactive Oxygen Species; Reperfusion Injury; Succinic Acid | 2015 |
Succinate Accumulation and Ischemia-Reperfusion Injury: Of Mice but Not Men, a Study in Renal Ischemia-Reperfusion.
Topics: Animals; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred C57BL; Mitochondria; Oxidative Str | 2016 |
Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation.
Topics: Animals; Cell Respiration; Female; Inflammation; Lipopolysaccharides; Macrophage Activation; Macroph | 2016 |
Contralateral leg as a control during skeletal muscle ischemia-reperfusion.
Topics: Animals; Ascorbic Acid; Cell Respiration; Electron Transport Chain Complex Proteins; Glutamic Acid; | 2009 |
Mitochondrial complex I, aconitase, and succinate dehydrogenase during hypoxia-reoxygenation: modulation of enzyme activities by MnSOD.
Topics: Aconitate Hydratase; Adenocarcinoma, Papillary; Adenoviridae; Aspartic Acid; Dithiothreitol; Electro | 2003 |
Production of reactive oxygen species by mitochondria: central role of complex III.
Topics: Animals; Antioxidants; Binding Sites; Catalase; Electron Transport; Electron Transport Complex III; | 2003 |
Effects of cytoflavin and neuronol on morphological changes in the brain and survival of rats with ischemic disturbances in cerebral blood flow.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Drug Combinations; Flavin Mononucleotid | 2004 |
Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria.
Topics: Animals; Electron Transport; Electron Transport Chain Complex Proteins; Electron Transport Complex I | 2008 |
[Correction of postischemic reperfusion injury complications by cytoflavin].
Topics: Animals; Antioxidants; Drug Combinations; Energy Metabolism; Flavin Mononucleotide; Inosine Diphosph | 2000 |
Investigations on the influence of copper succinate on the production of superoxide anion radicals by bovine small intestinal mucosa cells.
Topics: Animals; Animals, Newborn; Cattle; Cattle Diseases; Copper; Intestinal Mucosa; Intestine, Small; Mal | 1989 |