succinic acid has been researched along with Paraganglioma in 23 studies
Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.
Paraganglioma: A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion, such as the carotid body, or medulla of the adrenal gland (usually called a chromaffinoma or pheochromocytoma). It is more common in women than in men. (Stedman, 25th ed; from Segen, Dictionary of Modern Medicine, 1992)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recent reports indicate that cancer-secreted succinate enhances cancer cell migration and promotes cancer metastasis by activating succinate receptor-1 (SUCNR-1)-mediated signaling and transcription pathways." | 2.82 | Cancer-derived extracellular succinate: a driver of cancer metastasis. ( Kuo, CC; Wu, JY; Wu, KK, 2022) |
| "Paraganglioma and pheochromocytoma are examples, whose etiology and therapy are complicated by the absence of representative cell lines or animal models." | 1.51 | Modeling succinate dehydrogenase loss disorders in C. elegans through effects on hypoxia-inducible factor. ( Braun, MM; Chen, C; Damjanac, T; Hu, J; Maher, LJ; Zhang, Y, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (4.35) | 29.6817 |
| 2010's | 12 (52.17) | 24.3611 |
| 2020's | 10 (43.48) | 2.80 |
| Authors | Studies |
|---|---|
| Lamy, C | 1 |
| Tissot, H | 1 |
| Faron, M | 1 |
| Baudin, E | 1 |
| Lamartina, L | 1 |
| Pradon, C | 1 |
| Al Ghuzlan, A | 1 |
| Leboulleux, S | 1 |
| Perfettini, JL | 1 |
| Paci, A | 1 |
| Hadoux, J | 1 |
| Broutin, S | 1 |
| Gudgeon, N | 1 |
| Munford, H | 1 |
| Bishop, EL | 1 |
| Hill, J | 1 |
| Fulton-Ward, T | 1 |
| Bending, D | 1 |
| Roberts, J | 1 |
| Tennant, DA | 1 |
| Dimeloe, S | 1 |
| Kuo, CC | 1 |
| Wu, JY | 1 |
| Wu, KK | 1 |
| Branzoli, F | 3 |
| Salgues, B | 3 |
| Marjańska, M | 3 |
| Laloi-Michelin, M | 3 |
| Herman, P | 3 |
| Le Collen, L | 3 |
| Delemer, B | 3 |
| Riancho, J | 3 |
| Kuhn, E | 3 |
| Jublanc, C | 3 |
| Burnichon, N | 5 |
| Amar, L | 5 |
| Favier, J | 5 |
| Gimenez-Roqueplo, AP | 5 |
| Buffet, A | 5 |
| Lussey-Lepoutre, C | 5 |
| Bancel, LP | 1 |
| Masso, V | 1 |
| Dessein, AF | 1 |
| Aubert, S | 1 |
| Leteurtre, E | 1 |
| Coppin, L | 1 |
| Odou, MF | 1 |
| Cao, CD | 1 |
| Cardot-Bauters, C | 1 |
| Pigny, P | 1 |
| Wang, Y | 2 |
| Liu, B | 1 |
| Li, F | 1 |
| Zhang, Y | 2 |
| Gao, X | 1 |
| Zhou, H | 1 |
| Bellucci, A | 2 |
| Drossart, T | 1 |
| Fontaine, S | 2 |
| Clement, O | 1 |
| Benit, P | 2 |
| Rustin, P | 2 |
| Groussin, L | 1 |
| Meatchi, T | 1 |
| Tavitian, B | 2 |
| Braun, MM | 1 |
| Damjanac, T | 1 |
| Chen, C | 1 |
| Hu, J | 1 |
| Maher, LJ | 3 |
| Matlac, DM | 1 |
| Hadrava Vanova, K | 1 |
| Bechmann, N | 1 |
| Richter, S | 2 |
| Folberth, J | 1 |
| Ghayee, HK | 1 |
| Ge, GB | 1 |
| Abunimer, L | 1 |
| Wesley, R | 1 |
| Aherrahrou, R | 1 |
| Dona, M | 1 |
| Martínez-Montes, ÁM | 1 |
| Calsina, B | 1 |
| Merino, MJ | 1 |
| Schwaninger, M | 1 |
| Deen, PMT | 1 |
| Zhuang, Z | 1 |
| Neuzil, J | 1 |
| Pacak, K | 7 |
| Lehnert, H | 1 |
| Fliedner, SMJ | 1 |
| Hirose, R | 1 |
| Tsurutani, Y | 1 |
| Sugisawa, C | 1 |
| Inoue, K | 1 |
| Suematsu, S | 1 |
| Nagata, M | 1 |
| Hasegawa, N | 1 |
| Kakuta, Y | 1 |
| Yonamine, M | 1 |
| Takekoshi, K | 1 |
| Kimura, N | 1 |
| Saito, J | 1 |
| Nishikawa, T | 1 |
| Taïeb, D | 3 |
| Eijkelenkamp, K | 1 |
| Osinga, TE | 1 |
| Links, TP | 1 |
| van der Horst-Schrivers, ANA | 1 |
| Rao, JU | 2 |
| Engelke, UF | 1 |
| Rodenburg, RJ | 1 |
| Wevers, RA | 1 |
| Eisenhofer, G | 3 |
| Qin, N | 2 |
| Kusters, B | 1 |
| Goudswaard, AG | 1 |
| Lenders, JW | 2 |
| Hermus, AR | 1 |
| Mensenkamp, AR | 1 |
| Kunst, HP | 1 |
| Sweep, FC | 1 |
| Timmers, HJ | 2 |
| Lendvai, N | 1 |
| Pawlosky, R | 1 |
| Bullova, P | 1 |
| Patocs, A | 1 |
| Veech, RL | 1 |
| Imperiale, A | 2 |
| Moussallieh, FM | 2 |
| Sebag, F | 2 |
| Brunaud, L | 2 |
| Barlier, A | 2 |
| Elbayed, K | 2 |
| Bachellier, P | 2 |
| Goichot, B | 2 |
| Namer, IJ | 2 |
| Peitzsch, M | 1 |
| Rapizzi, E | 1 |
| de Cubas, AA | 1 |
| Schiavi, F | 1 |
| Beuschlein, F | 1 |
| Quinkler, M | 1 |
| Opocher, G | 1 |
| Mannelli, M | 1 |
| Robledo, M | 1 |
| Roche, P | 1 |
| Battini, S | 1 |
| Cicek, AE | 1 |
| Loundou, A | 1 |
| Stratakis, CA | 1 |
| Her, YF | 1 |
| Nelson-Holte, M | 1 |
| Morin, A | 1 |
| Janin, M | 1 |
| Ottolenghi, C | 1 |
| Zinzindohoué, F | 1 |
| Autret, G | 1 |
| Robidel, E | 1 |
| Banting, B | 1 |
| Cuenod, CA | 1 |
| Halimi, P | 1 |
| Fournier, L | 1 |
| Hoekstra, AS | 1 |
| Addie, RD | 1 |
| Ras, C | 1 |
| Seifar, RM | 1 |
| Ruivenkamp, CA | 1 |
| Briaire-de Bruijn, IH | 1 |
| Hes, FJ | 1 |
| Jansen, JC | 1 |
| Corssmit, EP | 1 |
| Corver, WE | 1 |
| Morreau, H | 1 |
| Bovée, JV | 1 |
| Bayley, JP | 1 |
| Devilee, P | 1 |
| Zu, TJ | 1 |
| Jia, MY | 1 |
| Yuan, RT | 1 |
| Bu, LX | 1 |
| Yao, RY | 1 |
| Hobert, JA | 1 |
| Mester, JL | 1 |
| Moline, J | 1 |
| Eng, C | 1 |
| Smith, EH | 1 |
| Janknecht, R | 1 |
4 reviews available for succinic acid and Paraganglioma
| Article | Year |
|---|---|
Cancer-derived extracellular succinate: a driver of cancer metastasis.
Topics: Extracellular Space; Humans; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; Paragan | 2022 |
The connection between tricarboxylic acid cycle enzyme mutations and pseudohypoxic signaling in pheochromocytoma and paraganglioma.
Topics: Adrenal Gland Neoplasms; Citric Acid Cycle; Dioxygenases; Fumarates; Humans; Ketoglutaric Acids; Mut | 2023 |
New Insights into the Nuclear Imaging Phenotypes of Cluster 1 Pheochromocytoma and Paraganglioma.
Topics: Adrenal Gland Neoplasms; Catecholamines; Fluorodeoxyglucose F18; Humans; Paraganglioma; Phenotype; P | 2017 |
Clinical implications of the oncometabolite succinate in SDHx-mutation carriers.
Topics: Adrenal Gland Neoplasms; Biomarkers, Tumor; Carcinoma, Renal Cell; Genetic Predisposition to Disease | 2020 |
19 other studies available for succinic acid and Paraganglioma
| Article | Year |
|---|---|
Succinate: A Serum Biomarker of SDHB-Mutated Paragangliomas and Pheochromocytomas.
Topics: Adrenal Gland Neoplasms; Biomarkers, Tumor; Germ-Line Mutation; Humans; Mutation; Paraganglioma; Phe | 2022 |
Succinate uptake by T cells suppresses their effector function via inhibition of mitochondrial glucose oxidation.
Topics: Adrenal Gland Neoplasms; CD8-Positive T-Lymphocytes; Cytokines; Glucose; Humans; Paraganglioma; Pheo | 2022 |
SDHx mutation and pituitary adenoma: can in vivo 1H-MR spectroscopy unravel the link?
Topics: Adenoma; Adrenal Gland Neoplasms; Germ-Line Mutation; Humans; Magnetic Resonance Spectroscopy; Mutat | 2023 |
SDHx mutation and pituitary adenoma: can in vivo 1H-MR spectroscopy unravel the link?
Topics: Adenoma; Adrenal Gland Neoplasms; Germ-Line Mutation; Humans; Magnetic Resonance Spectroscopy; Mutat | 2023 |
SDHx mutation and pituitary adenoma: can in vivo 1H-MR spectroscopy unravel the link?
Topics: Adenoma; Adrenal Gland Neoplasms; Germ-Line Mutation; Humans; Magnetic Resonance Spectroscopy; Mutat | 2023 |
SDHx mutation and pituitary adenoma: can in vivo 1H-MR spectroscopy unravel the link?
Topics: Adenoma; Adrenal Gland Neoplasms; Germ-Line Mutation; Humans; Magnetic Resonance Spectroscopy; Mutat | 2023 |
Serum Succinate/Fumarate Ratio in Patients With Paraganglioma/Pheochromocytoma Attending an Endocrine Oncogenetic Unit.
Topics: Adrenal Gland Neoplasms; Carcinogenesis; Cell Transformation, Neoplastic; Fumarates; Germ-Line Mutat | 2023 |
Succinate detection using in vivo
Topics: Adrenal Gland Neoplasms; Animals; Germ-Line Mutation; Humans; Magnetic Resonance Spectroscopy; Mice; | 2020 |
Modeling succinate dehydrogenase loss disorders in C. elegans through effects on hypoxia-inducible factor.
Topics: Adrenal Gland Neoplasms; Amino Acids, Dicarboxylic; Animals; Animals, Genetically Modified; Caenorha | 2019 |
Succinate Mediates Tumorigenic Effects
Topics: Animals; Humans; Mice; Mutation; Paraganglioma; Pheochromocytoma; Protein Subunits; Rats; Receptors, | 2021 |
Hereditary pheochromocytoma/paraganglioma syndrome with a novel mutation in the succinate dehydrogenase subunit B gene in a Japanese family: two case reports.
Topics: Adrenal Gland Neoplasms; Adult; Female; Humans; Japan; Mutation; Neoplasm Recurrence, Local; Paragan | 2021 |
Genotype-specific abnormalities in mitochondrial function associate with distinct profiles of energy metabolism and catecholamine content in pheochromocytoma and paraganglioma.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Catecholamines; Electron Transport Complex II; Energy Me | 2013 |
Succinate-to-fumarate ratio as a new metabolic marker to detect the presence of SDHB/D-related paraganglioma: initial experimental and ex vivo findings.
Topics: Adrenal Gland Neoplasms; Animals; Biomarkers, Tumor; Citric Acid Cycle; Female; Fumarates; Gene Expr | 2014 |
A new specific succinate-glutamate metabolomic hallmark in SDHx-related paragangliomas.
Topics: Glutamic Acid; Humans; Metabolomics; Models, Biological; Paraganglioma; Succinate Dehydrogenase; Suc | 2013 |
Krebs cycle metabolite profiling for identification and stratification of pheochromocytomas/paragangliomas due to succinate dehydrogenase deficiency.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Citric Acid Cycle; Female; Follow-Up Studies; Fuma | 2014 |
Metabolome profiling by HRMAS NMR spectroscopy of pheochromocytomas and paragangliomas detects SDH deficiency: clinical and pathophysiological implications.
Topics: Female; Humans; Immunohistochemistry; Male; Metabolic Networks and Pathways; Metabolome; Metabolomic | 2015 |
Oxygen concentration controls epigenetic effects in models of familial paraganglioma.
Topics: 5-Methylcytosine; Animals; Case-Control Studies; Cytosine; Dioxygenases; DNA Methylation; Epigenesis | 2015 |
In Vivo Detection of Succinate by Magnetic Resonance Spectroscopy as a Hallmark of SDHx Mutations in Paraganglioma.
Topics: Animals; Electron Transport Complex II; Genetic Predisposition to Disease; Germ-Line Mutation; Human | 2016 |
Parent-of-origin tumourigenesis is mediated by an essential imprinted modifier in SDHD-linked paragangliomas: SLC22A18 and CDKN1C are candidate tumour modifiers.
Topics: Cell Line, Tumor; Cell Proliferation; Chromosomes, Human, Pair 11; Cyclin-Dependent Kinase Inhibitor | 2016 |
[The mutations of germline succinate dehydrogrnase subunit B (SDHB) in sporadic paragangliomas].
Topics: DNA Mutational Analysis; Germ-Line Mutation; Humans; Mutation; Paraganglioma; Succinate Dehydrogenas | 2011 |
Elevated plasma succinate in PTEN, SDHB, and SDHD mutation-positive individuals.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carboxylic Acids; Child; Child, Preschool; Female; Follo | 2012 |
Succinate inhibition of alpha-ketoglutarate-dependent enzymes in a yeast model of paraganglioma.
Topics: Cells, Cultured; Citric Acid Cycle; Dioxygenases; Enzyme Inhibitors; Humans; Jumonji Domain-Containi | 2007 |