succinic acid has been researched along with Obesity in 22 studies
Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Obesity was associated with elevated levels of circulating succinate concomitant with impaired glucose metabolism." | 2.87 | Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota. ( Andrés-Lacueva, C; Bernal, R; Ceperuelo-Mallafré, V; Fernández-Real, JM; Fernández-Veledo, S; Gomez-Huelgas, R; Keiran, N; Moya, A; Pérez-Brocal, V; Queipo-Ortuño, MI; Sabater, M; Serena, C; Tinahones, FJ; Urpi-Sarda, M; Vendrell, J, 2018) |
| "Obesity is one of the leading noncommunicable diseases in the world." | 1.91 | Exogenous succinate impacts mouse brown adipose tissue mitochondrial proteome and potentiates body mass reduction induced by liraglutide. ( Araujo, EP; Carregari, VC; Catharino, RR; Delafiori, J; Gaspar, RS; Martins-de-Souza, D; Morari, J; Prado, TP; Sidarta-Oliveira, D; Solon, CS; Velloso, LA; Zuccoli, G, 2023) |
| "Insulin sensitivity was determined with the isoglycaemic-hyperinsulinaemic clamp technique." | 1.37 | Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes. ( Andersen, JL; Dela, F; Hansen, CN; Helge, JW; Hey-Mogensen, M; Larsen, S; Madsbad, S; Stride, N; Worm, D, 2011) |
| "Although obesity is a risk factor for development of type 2 diabetes and chemical modification of proteins by advanced glycoxidation and lipoxidation end products is implicated in the development of diabetic complications, little is known about the chemical modification of proteins in adipocytes or adipose tissue." | 1.34 | Succination of protein thiols during adipocyte maturation: a biomarker of mitochondrial stress. ( Baatz, JE; Baynes, JW; Bethard, J; Blatnik, M; Brock, JW; Frizzell, N; Nagai, R; Thorpe, SR; Walla, MD, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (9.09) | 29.6817 |
| 2010's | 10 (45.45) | 24.3611 |
| 2020's | 9 (40.91) | 2.80 |
| Authors | Studies |
|---|---|
| Mu, WJ | 1 |
| Zhu, JY | 1 |
| Chen, M | 1 |
| Guo, L | 1 |
| Liu, X | 1 |
| Chen, Y | 1 |
| Zhao, L | 1 |
| Tian, Q | 1 |
| deAvila, JM | 1 |
| Zhu, MJ | 1 |
| Du, M | 1 |
| Huber-Ruano, I | 1 |
| Calvo, E | 2 |
| Mayneris-Perxachs, J | 1 |
| Rodríguez-Peña, MM | 1 |
| Ceperuelo-Mallafré, V | 3 |
| Cedó, L | 1 |
| Núñez-Roa, C | 2 |
| Miro-Blanch, J | 1 |
| Arnoriaga-Rodríguez, M | 1 |
| Balvay, A | 1 |
| Maudet, C | 1 |
| García-Roves, P | 1 |
| Yanes, O | 1 |
| Rabot, S | 1 |
| Grimaud, GM | 1 |
| De Prisco, A | 1 |
| Amoruso, A | 1 |
| Fernández-Real, JM | 2 |
| Vendrell, J | 3 |
| Fernández-Veledo, S | 3 |
| Liao, FH | 1 |
| Yao, CN | 1 |
| Chen, SP | 1 |
| Wu, TH | 1 |
| Lin, SY | 1 |
| Gaspar, RS | 1 |
| Delafiori, J | 1 |
| Zuccoli, G | 1 |
| Carregari, VC | 1 |
| Prado, TP | 1 |
| Morari, J | 1 |
| Sidarta-Oliveira, D | 1 |
| Solon, CS | 1 |
| Catharino, RR | 1 |
| Araujo, EP | 1 |
| Martins-de-Souza, D | 1 |
| Velloso, LA | 1 |
| Li, X | 1 |
| Huang, G | 1 |
| Zhang, Y | 1 |
| Ren, Y | 2 |
| Zhang, R | 1 |
| Zhu, W | 1 |
| Yu, K | 1 |
| Liu, K | 1 |
| Lin, L | 1 |
| Li, Q | 1 |
| Xue, Y | 1 |
| Zheng, F | 1 |
| Wang, G | 2 |
| Zheng, C | 1 |
| Du, L | 1 |
| Hu, M | 1 |
| Huang, Y | 1 |
| Shao, C | 1 |
| Kong, X | 1 |
| Melino, G | 1 |
| Shi, Y | 1 |
| Wang, Y | 2 |
| Ives, SJ | 1 |
| Zaleski, KS | 1 |
| Slocum, C | 1 |
| Escudero, D | 1 |
| Sheridan, C | 1 |
| Legesse, S | 1 |
| Vidal, K | 1 |
| Lagalwar, S | 1 |
| Reynolds, TH | 1 |
| Wang, Z | 1 |
| Wang, QA | 1 |
| Liu, Y | 1 |
| Jiang, L | 1 |
| Serena, C | 2 |
| Keiran, N | 2 |
| Queipo-Ortuño, MI | 1 |
| Bernal, R | 1 |
| Gomez-Huelgas, R | 1 |
| Urpi-Sarda, M | 1 |
| Sabater, M | 1 |
| Pérez-Brocal, V | 1 |
| Andrés-Lacueva, C | 1 |
| Moya, A | 1 |
| Tinahones, FJ | 1 |
| Mills, EL | 1 |
| Pierce, KA | 1 |
| Jedrychowski, MP | 1 |
| Garrity, R | 1 |
| Winther, S | 1 |
| Vidoni, S | 1 |
| Yoneshiro, T | 1 |
| Spinelli, JB | 1 |
| Lu, GZ | 1 |
| Kazak, L | 1 |
| Banks, AS | 1 |
| Haigis, MC | 1 |
| Kajimura, S | 1 |
| Murphy, MP | 1 |
| Gygi, SP | 1 |
| Clish, CB | 1 |
| Chouchani, ET | 1 |
| Wang, K | 1 |
| Liao, M | 1 |
| Zhou, N | 1 |
| Bao, L | 1 |
| Ma, K | 1 |
| Zheng, Z | 1 |
| Liu, C | 1 |
| Wang, W | 1 |
| Wang, J | 1 |
| Liu, SJ | 1 |
| Liu, H | 1 |
| Hernández-Alvarez, MI | 1 |
| Ejarque, M | 1 |
| Horrillo, D | 1 |
| Maymó-Masip, E | 1 |
| Rodríguez, MM | 1 |
| Fradera, R | 1 |
| de la Rosa, JV | 1 |
| Jorba, R | 1 |
| Megia, A | 1 |
| Zorzano, A | 1 |
| Medina-Gómez, G | 1 |
| Castrillo, A | 1 |
| Meyer, JG | 1 |
| Cai, W | 1 |
| Softic, S | 1 |
| Li, ME | 1 |
| Verdin, E | 1 |
| Newgard, C | 1 |
| Schilling, B | 1 |
| Kahn, CR | 1 |
| Vasan, SK | 1 |
| Noordam, R | 1 |
| Gowri, MS | 1 |
| Neville, MJ | 1 |
| Karpe, F | 1 |
| Christodoulides, C | 1 |
| Boulangé, CL | 1 |
| Claus, SP | 1 |
| Chou, CJ | 1 |
| Collino, S | 1 |
| Montoliu, I | 1 |
| Kochhar, S | 1 |
| Holmes, E | 1 |
| Rezzi, S | 1 |
| Nicholson, JK | 1 |
| Dumas, ME | 1 |
| Martin, FP | 1 |
| Gupte, AA | 1 |
| Minze, LJ | 1 |
| Reyes, M | 1 |
| Wang, X | 1 |
| Brunner, G | 1 |
| Ghosn, M | 1 |
| Cordero-Reyes, AM | 1 |
| Ding, K | 1 |
| Pratico, D | 1 |
| Morrisett, J | 1 |
| Shi, ZZ | 1 |
| Hamilton, DJ | 1 |
| Lyon, CJ | 1 |
| Hsueh, WA | 1 |
| Gattu, AK | 1 |
| Birkenfeld, AL | 1 |
| Iwakiri, Y | 1 |
| Jay, S | 1 |
| Saltzman, M | 1 |
| Doll, J | 1 |
| Protiva, P | 1 |
| Samuel, VT | 1 |
| Crawford, SE | 1 |
| Chung, C | 1 |
| Larsen, S | 1 |
| Stride, N | 1 |
| Hey-Mogensen, M | 1 |
| Hansen, CN | 1 |
| Andersen, JL | 1 |
| Madsbad, S | 1 |
| Worm, D | 1 |
| Helge, JW | 1 |
| Dela, F | 1 |
| Williams, RE | 1 |
| Lenz, EM | 1 |
| Evans, JA | 1 |
| Wilson, ID | 1 |
| Granger, JH | 1 |
| Plumb, RS | 1 |
| Stumpf, CL | 1 |
| Nagai, R | 1 |
| Brock, JW | 1 |
| Blatnik, M | 1 |
| Baatz, JE | 1 |
| Bethard, J | 1 |
| Walla, MD | 1 |
| Thorpe, SR | 1 |
| Baynes, JW | 1 |
| Frizzell, N | 1 |
| Rogers, KS | 1 |
| Higgins, ES | 1 |
| Loria, RM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| LIFESTAT - Living With Statins, a Cross Sectional Study on the Impact of Cholesterol Lowering Drugs on Health, Lifestyle and Well-being[NCT02250677] | 75 participants (Actual) | Observational | 2014-04-30 | Completed | |||
| Living With Statins - The Impact of Cholesterol Lowering Drugs on Health, Lifestyle and Well-being[NCT02796378] | Phase 4 | 30 participants (Anticipated) | Interventional | 2016-06-30 | Active, not recruiting | ||
| Living With Statins - The Impact of Cholesterol Lowering Drugs on Health, Lifestyle and Well-being[NCT02255682] | Phase 4 | 35 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for succinic acid and Obesity
| Article | Year |
|---|---|
Exercise-Mediated Browning of White Adipose Tissue: Its Significance, Mechanism and Effectiveness.
Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Energy Metabolism; Exercise; Exercise Therapy | 2021 |
Energy metabolism in brown adipose tissue.
Topics: Adipocytes, Brown; Adipose Tissue, Brown; Amino Acids, Branched-Chain; Animals; Energy Metabolism; F | 2021 |
1 trial available for succinic acid and Obesity
| Article | Year |
|---|---|
Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota.
Topics: Adult; Aged; Bacteria; Biomarkers; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Gastr | 2018 |
19 other studies available for succinic acid and Obesity
| Article | Year |
|---|---|
Dietary succinate supplementation to maternal mice improves fetal brown adipose tissue development and thermogenesis of female offspring.
Topics: Adipogenesis; Adipose Tissue, Brown; Animals; Animals, Newborn; Cell Line; Diet, High-Fat; Dietary S | 2022 |
Orally administered Odoribacter laneus improves glucose control and inflammatory profile in obese mice by depleting circulating succinate.
Topics: Animals; Bacteroidetes; Blood Glucose; Diabetes Mellitus, Type 2; Diet, High-Fat; Humans; Inflammati | 2022 |
Transdermal Delivery of Succinate Accelerates Energy Dissipation of Brown Adipocytes to Reduce Remote Fat Accumulation.
Topics: Adipocytes, Brown; Animals; Diet, High-Fat; Energy Metabolism; Mice; Mice, Inbred C57BL; Obesity; Su | 2022 |
Exogenous succinate impacts mouse brown adipose tissue mitochondrial proteome and potentiates body mass reduction induced by liraglutide.
Topics: Adipose Tissue, Brown; Animals; Energy Metabolism; Liraglutide; Mice; Obesity; Proteome; Succinic Ac | 2023 |
Succinate signaling attenuates high-fat diet-induced metabolic disturbance and intestinal barrier dysfunction.
Topics: Animals; Diet, High-Fat; Gastrointestinal Diseases; Inflammation; Intestinal Diseases; Mice; Mice, I | 2023 |
Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II.
Topics: Adipocytes, Beige; Adipogenesis; Animals; Electron Transport Complex II; Energy Metabolism; Fats; Fa | 2020 |
The effect of succinic acid on the metabolic profile in high-fat diet-induced obesity and insulin resistance.
Topics: Animals; Body Weight; Diet, High-Fat; Energy Metabolism; Insulin Resistance; Male; Metabolome; Mice; | 2020 |
Accumulation of succinate controls activation of adipose tissue thermogenesis.
Topics: Adipocytes; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Female; Male; Metabolomics; Mice; | 2018 |
Parabacteroides distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids.
Topics: Animals; Bacterial Proteins; Bacteroidetes; Bile Acids and Salts; Gastrointestinal Microbiome; Human | 2019 |
SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity.
Topics: Adipose Tissue; Animals; Cells, Cultured; Cytokines; Gene Expression Profiling; Humans; Inflammation | 2019 |
Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation.
Topics: Adipose Tissue, Brown; Animals; Energy Metabolism; Gene Expression Regulation; Glucose; Mice; Mice, | 2019 |
The proposed systemic thermogenic metabolites succinate and 12,13-diHOME are inversely associated with adiposity and related metabolic traits: evidence from a large human cross-sectional study.
Topics: Adipocytes; Adipose Tissue, Brown; Adiposity; Adult; Body Mass Index; Cross-Sectional Studies; Energ | 2019 |
Early metabolic adaptation in C57BL/6 mice resistant to high fat diet induced weight gain involves an activation of mitochondrial oxidative pathways.
Topics: Adaptation, Physiological; Animals; Diet, High-Fat; Female; Hemiterpenes; Keto Acids; Magnetic Reson | 2013 |
High-fat feeding-induced hyperinsulinemia increases cardiac glucose uptake and mitochondrial function despite peripheral insulin resistance.
Topics: Age Factors; Animals; Atherosclerosis; Blotting, Western; Diet, High-Fat; Fatty Liver; Glucose; Glut | 2013 |
Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling.
Topics: Adipocytes; Animals; Eye Proteins; Gene Expression Regulation; Glucose Tolerance Test; Hepatocytes; | 2014 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
A combined (1)H NMR and HPLC-MS-based metabonomic study of urine from obese (fa/fa) Zucker and normal Wistar-derived rats.
Topics: Acetates; Animals; Betaine; Biomarkers; Chromatography, High Pressure Liquid; Circadian Rhythm; Fema | 2005 |
Succination of protein thiols during adipocyte maturation: a biomarker of mitochondrial stress.
Topics: 3T3 Cells; Adipocytes; Adipogenesis; Adipose Tissue; Animals; Biomarkers; Cell Differentiation; Citr | 2007 |
Influence of genetic predisposition to diabetes and obesity on mitochondrial function.
Topics: Animals; Diabetes Mellitus, Experimental; Genotype; Glutamates; Glutamic Acid; Liver; Male; Mice; Mi | 1986 |