Page last updated: 2024-10-20

succinic acid and Obesity

succinic acid has been researched along with Obesity in 22 studies

Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.

Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).

Research Excerpts

ExcerptRelevanceReference
"Obesity was associated with elevated levels of circulating succinate concomitant with impaired glucose metabolism."2.87Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota. ( Andrés-Lacueva, C; Bernal, R; Ceperuelo-Mallafré, V; Fernández-Real, JM; Fernández-Veledo, S; Gomez-Huelgas, R; Keiran, N; Moya, A; Pérez-Brocal, V; Queipo-Ortuño, MI; Sabater, M; Serena, C; Tinahones, FJ; Urpi-Sarda, M; Vendrell, J, 2018)
"Obesity is one of the leading noncommunicable diseases in the world."1.91Exogenous succinate impacts mouse brown adipose tissue mitochondrial proteome and potentiates body mass reduction induced by liraglutide. ( Araujo, EP; Carregari, VC; Catharino, RR; Delafiori, J; Gaspar, RS; Martins-de-Souza, D; Morari, J; Prado, TP; Sidarta-Oliveira, D; Solon, CS; Velloso, LA; Zuccoli, G, 2023)
"Insulin sensitivity was determined with the isoglycaemic-hyperinsulinaemic clamp technique."1.37Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes. ( Andersen, JL; Dela, F; Hansen, CN; Helge, JW; Hey-Mogensen, M; Larsen, S; Madsbad, S; Stride, N; Worm, D, 2011)
"Although obesity is a risk factor for development of type 2 diabetes and chemical modification of proteins by advanced glycoxidation and lipoxidation end products is implicated in the development of diabetic complications, little is known about the chemical modification of proteins in adipocytes or adipose tissue."1.34Succination of protein thiols during adipocyte maturation: a biomarker of mitochondrial stress. ( Baatz, JE; Baynes, JW; Bethard, J; Blatnik, M; Brock, JW; Frizzell, N; Nagai, R; Thorpe, SR; Walla, MD, 2007)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.55)18.7374
1990's0 (0.00)18.2507
2000's2 (9.09)29.6817
2010's10 (45.45)24.3611
2020's9 (40.91)2.80

Authors

AuthorsStudies
Mu, WJ1
Zhu, JY1
Chen, M1
Guo, L1
Liu, X1
Chen, Y1
Zhao, L1
Tian, Q1
deAvila, JM1
Zhu, MJ1
Du, M1
Huber-Ruano, I1
Calvo, E2
Mayneris-Perxachs, J1
Rodríguez-Peña, MM1
Ceperuelo-Mallafré, V3
Cedó, L1
Núñez-Roa, C2
Miro-Blanch, J1
Arnoriaga-Rodríguez, M1
Balvay, A1
Maudet, C1
García-Roves, P1
Yanes, O1
Rabot, S1
Grimaud, GM1
De Prisco, A1
Amoruso, A1
Fernández-Real, JM2
Vendrell, J3
Fernández-Veledo, S3
Liao, FH1
Yao, CN1
Chen, SP1
Wu, TH1
Lin, SY1
Gaspar, RS1
Delafiori, J1
Zuccoli, G1
Carregari, VC1
Prado, TP1
Morari, J1
Sidarta-Oliveira, D1
Solon, CS1
Catharino, RR1
Araujo, EP1
Martins-de-Souza, D1
Velloso, LA1
Li, X1
Huang, G1
Zhang, Y1
Ren, Y2
Zhang, R1
Zhu, W1
Yu, K1
Liu, K1
Lin, L1
Li, Q1
Xue, Y1
Zheng, F1
Wang, G2
Zheng, C1
Du, L1
Hu, M1
Huang, Y1
Shao, C1
Kong, X1
Melino, G1
Shi, Y1
Wang, Y2
Ives, SJ1
Zaleski, KS1
Slocum, C1
Escudero, D1
Sheridan, C1
Legesse, S1
Vidal, K1
Lagalwar, S1
Reynolds, TH1
Wang, Z1
Wang, QA1
Liu, Y1
Jiang, L1
Serena, C2
Keiran, N2
Queipo-Ortuño, MI1
Bernal, R1
Gomez-Huelgas, R1
Urpi-Sarda, M1
Sabater, M1
Pérez-Brocal, V1
Andrés-Lacueva, C1
Moya, A1
Tinahones, FJ1
Mills, EL1
Pierce, KA1
Jedrychowski, MP1
Garrity, R1
Winther, S1
Vidoni, S1
Yoneshiro, T1
Spinelli, JB1
Lu, GZ1
Kazak, L1
Banks, AS1
Haigis, MC1
Kajimura, S1
Murphy, MP1
Gygi, SP1
Clish, CB1
Chouchani, ET1
Wang, K1
Liao, M1
Zhou, N1
Bao, L1
Ma, K1
Zheng, Z1
Liu, C1
Wang, W1
Wang, J1
Liu, SJ1
Liu, H1
Hernández-Alvarez, MI1
Ejarque, M1
Horrillo, D1
Maymó-Masip, E1
Rodríguez, MM1
Fradera, R1
de la Rosa, JV1
Jorba, R1
Megia, A1
Zorzano, A1
Medina-Gómez, G1
Castrillo, A1
Meyer, JG1
Cai, W1
Softic, S1
Li, ME1
Verdin, E1
Newgard, C1
Schilling, B1
Kahn, CR1
Vasan, SK1
Noordam, R1
Gowri, MS1
Neville, MJ1
Karpe, F1
Christodoulides, C1
Boulangé, CL1
Claus, SP1
Chou, CJ1
Collino, S1
Montoliu, I1
Kochhar, S1
Holmes, E1
Rezzi, S1
Nicholson, JK1
Dumas, ME1
Martin, FP1
Gupte, AA1
Minze, LJ1
Reyes, M1
Wang, X1
Brunner, G1
Ghosn, M1
Cordero-Reyes, AM1
Ding, K1
Pratico, D1
Morrisett, J1
Shi, ZZ1
Hamilton, DJ1
Lyon, CJ1
Hsueh, WA1
Gattu, AK1
Birkenfeld, AL1
Iwakiri, Y1
Jay, S1
Saltzman, M1
Doll, J1
Protiva, P1
Samuel, VT1
Crawford, SE1
Chung, C1
Larsen, S1
Stride, N1
Hey-Mogensen, M1
Hansen, CN1
Andersen, JL1
Madsbad, S1
Worm, D1
Helge, JW1
Dela, F1
Williams, RE1
Lenz, EM1
Evans, JA1
Wilson, ID1
Granger, JH1
Plumb, RS1
Stumpf, CL1
Nagai, R1
Brock, JW1
Blatnik, M1
Baatz, JE1
Bethard, J1
Walla, MD1
Thorpe, SR1
Baynes, JW1
Frizzell, N1
Rogers, KS1
Higgins, ES1
Loria, RM1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
LIFESTAT - Living With Statins, a Cross Sectional Study on the Impact of Cholesterol Lowering Drugs on Health, Lifestyle and Well-being[NCT02250677]75 participants (Actual)Observational2014-04-30Completed
Living With Statins - The Impact of Cholesterol Lowering Drugs on Health, Lifestyle and Well-being[NCT02796378]Phase 430 participants (Anticipated)Interventional2016-06-30Active, not recruiting
Living With Statins - The Impact of Cholesterol Lowering Drugs on Health, Lifestyle and Well-being[NCT02255682]Phase 435 participants (Actual)Interventional2015-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for succinic acid and Obesity

ArticleYear
Exercise-Mediated Browning of White Adipose Tissue: Its Significance, Mechanism and Effectiveness.
    International journal of molecular sciences, 2021, Oct-26, Volume: 22, Issue:21

    Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Energy Metabolism; Exercise; Exercise Therapy

2021
Energy metabolism in brown adipose tissue.
    The FEBS journal, 2021, Volume: 288, Issue:12

    Topics: Adipocytes, Brown; Adipose Tissue, Brown; Amino Acids, Branched-Chain; Animals; Energy Metabolism; F

2021

Trials

1 trial available for succinic acid and Obesity

ArticleYear
Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota.
    The ISME journal, 2018, Volume: 12, Issue:7

    Topics: Adult; Aged; Bacteria; Biomarkers; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Gastr

2018

Other Studies

19 other studies available for succinic acid and Obesity

ArticleYear
Dietary succinate supplementation to maternal mice improves fetal brown adipose tissue development and thermogenesis of female offspring.
    The Journal of nutritional biochemistry, 2022, Volume: 100

    Topics: Adipogenesis; Adipose Tissue, Brown; Animals; Animals, Newborn; Cell Line; Diet, High-Fat; Dietary S

2022
Orally administered Odoribacter laneus improves glucose control and inflammatory profile in obese mice by depleting circulating succinate.
    Microbiome, 2022, 08-25, Volume: 10, Issue:1

    Topics: Animals; Bacteroidetes; Blood Glucose; Diabetes Mellitus, Type 2; Diet, High-Fat; Humans; Inflammati

2022
Transdermal Delivery of Succinate Accelerates Energy Dissipation of Brown Adipocytes to Reduce Remote Fat Accumulation.
    Molecular pharmaceutics, 2022, 11-07, Volume: 19, Issue:11

    Topics: Adipocytes, Brown; Animals; Diet, High-Fat; Energy Metabolism; Mice; Mice, Inbred C57BL; Obesity; Su

2022
Exogenous succinate impacts mouse brown adipose tissue mitochondrial proteome and potentiates body mass reduction induced by liraglutide.
    American journal of physiology. Endocrinology and metabolism, 2023, 03-01, Volume: 324, Issue:3

    Topics: Adipose Tissue, Brown; Animals; Energy Metabolism; Liraglutide; Mice; Obesity; Proteome; Succinic Ac

2023
Succinate signaling attenuates high-fat diet-induced metabolic disturbance and intestinal barrier dysfunction.
    Pharmacological research, 2023, Volume: 194

    Topics: Animals; Diet, High-Fat; Gastrointestinal Diseases; Inflammation; Intestinal Diseases; Mice; Mice, I

2023
Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 02-04, Volume: 117, Issue:5

    Topics: Adipocytes, Beige; Adipogenesis; Animals; Electron Transport Complex II; Energy Metabolism; Fats; Fa

2020
The effect of succinic acid on the metabolic profile in high-fat diet-induced obesity and insulin resistance.
    Physiological reports, 2020, Volume: 8, Issue:21

    Topics: Animals; Body Weight; Diet, High-Fat; Energy Metabolism; Insulin Resistance; Male; Metabolome; Mice;

2020
Accumulation of succinate controls activation of adipose tissue thermogenesis.
    Nature, 2018, Volume: 560, Issue:7716

    Topics: Adipocytes; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Female; Male; Metabolomics; Mice;

2018
Parabacteroides distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids.
    Cell reports, 2019, 01-02, Volume: 26, Issue:1

    Topics: Animals; Bacterial Proteins; Bacteroidetes; Bile Acids and Salts; Gastrointestinal Microbiome; Human

2019
SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity.
    Nature immunology, 2019, Volume: 20, Issue:5

    Topics: Adipose Tissue; Animals; Cells, Cultured; Cytokines; Gene Expression Profiling; Humans; Inflammation

2019
Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation.
    Molecular cell, 2019, 05-16, Volume: 74, Issue:4

    Topics: Adipose Tissue, Brown; Animals; Energy Metabolism; Gene Expression Regulation; Glucose; Mice; Mice,

2019
The proposed systemic thermogenic metabolites succinate and 12,13-diHOME are inversely associated with adiposity and related metabolic traits: evidence from a large human cross-sectional study.
    Diabetologia, 2019, Volume: 62, Issue:11

    Topics: Adipocytes; Adipose Tissue, Brown; Adiposity; Adult; Body Mass Index; Cross-Sectional Studies; Energ

2019
Early metabolic adaptation in C57BL/6 mice resistant to high fat diet induced weight gain involves an activation of mitochondrial oxidative pathways.
    Journal of proteome research, 2013, Apr-05, Volume: 12, Issue:4

    Topics: Adaptation, Physiological; Animals; Diet, High-Fat; Female; Hemiterpenes; Keto Acids; Magnetic Reson

2013
High-fat feeding-induced hyperinsulinemia increases cardiac glucose uptake and mitochondrial function despite peripheral insulin resistance.
    Endocrinology, 2013, Volume: 154, Issue:8

    Topics: Age Factors; Animals; Atherosclerosis; Blotting, Western; Diet, High-Fat; Fatty Liver; Glucose; Glut

2013
Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling.
    Endocrinology, 2014, Volume: 155, Issue:4

    Topics: Adipocytes; Animals; Eye Proteins; Gene Expression Regulation; Glucose Tolerance Test; Hepatocytes;

2014
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
    Diabetologia, 2011, Volume: 54, Issue:6

    Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2;

2011
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
    Diabetologia, 2011, Volume: 54, Issue:6

    Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2;

2011
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
    Diabetologia, 2011, Volume: 54, Issue:6

    Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2;

2011
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
    Diabetologia, 2011, Volume: 54, Issue:6

    Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2;

2011
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
    Diabetologia, 2011, Volume: 54, Issue:6

    Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2;

2011
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
    Diabetologia, 2011, Volume: 54, Issue:6

    Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2;

2011
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
    Diabetologia, 2011, Volume: 54, Issue:6

    Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2;

2011
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
    Diabetologia, 2011, Volume: 54, Issue:6

    Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2;

2011
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
    Diabetologia, 2011, Volume: 54, Issue:6

    Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2;

2011
A combined (1)H NMR and HPLC-MS-based metabonomic study of urine from obese (fa/fa) Zucker and normal Wistar-derived rats.
    Journal of pharmaceutical and biomedical analysis, 2005, Jul-01, Volume: 38, Issue:3

    Topics: Acetates; Animals; Betaine; Biomarkers; Chromatography, High Pressure Liquid; Circadian Rhythm; Fema

2005
Succination of protein thiols during adipocyte maturation: a biomarker of mitochondrial stress.
    The Journal of biological chemistry, 2007, Nov-23, Volume: 282, Issue:47

    Topics: 3T3 Cells; Adipocytes; Adipogenesis; Adipose Tissue; Animals; Biomarkers; Cell Differentiation; Citr

2007
Influence of genetic predisposition to diabetes and obesity on mitochondrial function.
    Biochemical medicine and metabolic biology, 1986, Volume: 35, Issue:1

    Topics: Animals; Diabetes Mellitus, Experimental; Genotype; Glutamates; Glutamic Acid; Liver; Male; Mice; Mi

1986