succinic acid has been researched along with Leigh Disease in 2 studies
Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.
Leigh Disease: A group of metabolic disorders primarily of infancy characterized by the subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, dysphagia, and lactic acidosis. Pathological features include spongy degeneration of the neuropile of the basal ganglia, thalamus, brain stem, and spinal cord. Patterns of inheritance include X-linked recessive, autosomal recessive, and mitochondrial. Leigh disease has been associated with mutations in genes for the PYRUVATE DEHYDROGENASE COMPLEX; CYTOCHROME-C OXIDASE; ATP synthase subunit 6; and subunits of mitochondrial complex I. (From Menkes, Textbook of Child Neurology, 5th ed, p850).
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bakare, AB | 1 |
| Rao, RR | 1 |
| Iyer, S | 1 |
| Ehinger, JK | 1 |
| Piel, S | 1 |
| Ford, R | 1 |
| Karlsson, M | 1 |
| Sjövall, F | 1 |
| Frostner, EÅ | 1 |
| Morota, S | 1 |
| Taylor, RW | 1 |
| Turnbull, DM | 1 |
| Cornell, C | 1 |
| Moss, SJ | 1 |
| Metzsch, C | 1 |
| Hansson, MJ | 1 |
| Fliri, H | 1 |
| Elmér, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Mitochondrial Targeted Biofuels as Countermeasures Against Chemical Threats[NCT03597438] | 700 participants (Anticipated) | Observational | 2018-05-07 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for succinic acid and Leigh Disease
| Article | Year |
|---|---|
Cell-Permeable Succinate Increases Mitochondrial Membrane Potential and Glycolysis in Leigh Syndrome Patient Fibroblasts.
Topics: Case-Control Studies; Citric Acid Cycle; DNA, Mitochondrial; Electron Transport Complex I; Energy Me | 2021 |
Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency.
Topics: Cell Membrane Permeability; Cell Respiration; Drug Discovery; Drug Evaluation, Preclinical; Electron | 2016 |