succinic acid has been researched along with Injury, Myocardial Reperfusion in 19 studies
Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To establish cardiomyocyte hypoxia/reoxygenation injury model by culturing primary cardiomyocytes from suckling SD rats, in order to study the effect of succinic acid on LDH leakage rate cardiomyocyte ischemia/reperfusion injury." | 7.79 | [Protective effect of succinic acid on primary cardiomyocyte hypoxia/reoxygenation injury]. ( Dong, W; Hou, JC; Li, L; Li, P; Liu, JX; Tang, XL; Zheng, YQ, 2013) |
| "To establish cardiomyocyte hypoxia/reoxygenation injury model by culturing primary cardiomyocytes from suckling SD rats, in order to study the effect of succinic acid on LDH leakage rate cardiomyocyte ischemia/reperfusion injury." | 3.79 | [Protective effect of succinic acid on primary cardiomyocyte hypoxia/reoxygenation injury]. ( Dong, W; Hou, JC; Li, L; Li, P; Liu, JX; Tang, XL; Zheng, YQ, 2013) |
| "In total, 115 patients undergoing acute STEMI and 26 control patients were included." | 1.48 | Metabolomic Profiling in Acute ST-Segment-Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia-Reperfusion Injury. ( Banning, AP; Channon, KM; Choudhury, RP; Costa, ASH; Dawkins, S; Frezza, C; Kharbanda, RK; Kohlhauer, M; Krieg, T; Lee, R; Murphy, MP; Pell, VR; Saeb-Parsy, K; Young, T, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 11 (57.89) | 24.3611 |
| 2020's | 2 (10.53) | 2.80 |
| Authors | Studies |
|---|---|
| Prag, HA | 2 |
| Pala, L | 1 |
| Kula-Alwar, D | 1 |
| Mulvey, JF | 3 |
| Luping, D | 1 |
| Beach, TE | 2 |
| Booty, LM | 1 |
| Hall, AR | 1 |
| Logan, A | 2 |
| Sauchanka, V | 1 |
| Caldwell, ST | 1 |
| Robb, EL | 1 |
| James, AM | 3 |
| Xu, Z | 1 |
| Saeb-Parsy, K | 3 |
| Hartley, RC | 1 |
| Murphy, MP | 6 |
| Krieg, T | 6 |
| Gruszczyk, AV | 2 |
| Huang, MM | 1 |
| Young, T | 2 |
| Tronci, L | 1 |
| Nikitopoulou, E | 1 |
| Ascione, R | 1 |
| Hadjihambi, A | 1 |
| Shattock, MJ | 1 |
| Pellerin, L | 1 |
| Frezza, C | 5 |
| Aksentijević, D | 1 |
| Andrienko, TN | 1 |
| Pasdois, P | 1 |
| Pereira, GC | 1 |
| Ovens, MJ | 1 |
| Halestrap, AP | 1 |
| Li, J | 1 |
| Yang, YL | 1 |
| Li, LZ | 1 |
| Zhang, L | 1 |
| Liu, Q | 1 |
| Liu, K | 1 |
| Li, P | 2 |
| Liu, B | 1 |
| Qi, LW | 1 |
| Kohlhauer, M | 2 |
| Dawkins, S | 1 |
| Costa, ASH | 3 |
| Lee, R | 1 |
| Pell, VR | 4 |
| Choudhury, RP | 1 |
| Banning, AP | 1 |
| Kharbanda, RK | 1 |
| Channon, KM | 1 |
| Spiroski, AM | 2 |
| Mulvey, J | 1 |
| Burger, N | 2 |
| Rosa, T | 1 |
| Gruszczyk, A | 1 |
| Mottahedin, A | 1 |
| Ghaleh, B | 1 |
| Tissier, R | 1 |
| Liu, L | 1 |
| Wang, Q | 1 |
| Zhao, B | 1 |
| Wu, Q | 1 |
| Wang, P | 1 |
| Tang, XL | 1 |
| Liu, JX | 1 |
| Dong, W | 1 |
| Li, L | 1 |
| Zheng, YQ | 1 |
| Hou, JC | 1 |
| Woodman, OL | 1 |
| Long, R | 1 |
| Pons, S | 1 |
| Eychenne, N | 1 |
| Berdeaux, A | 1 |
| Morin, D | 1 |
| Boylston, JA | 1 |
| Sun, J | 1 |
| Chen, Y | 1 |
| Gucek, M | 1 |
| Sack, MN | 1 |
| Murphy, E | 1 |
| Monte, E | 1 |
| Lopez, R | 1 |
| Vondriska, TM | 1 |
| Chouchani, ET | 1 |
| Lashin, O | 1 |
| Romani, A | 1 |
| Starnes, JW | 1 |
| Barnes, BD | 1 |
| Olsen, ME | 1 |
| Cairns, CB | 1 |
| Ferroggiaro, AA | 1 |
| Walther, JM | 1 |
| Harken, AH | 1 |
| Banerjee, A | 1 |
| Sakamoto, M | 1 |
| Takeshige, K | 1 |
| Yasui, H | 1 |
| Tokunaga, K | 1 |
| Kowaltowski, AJ | 1 |
| Seetharaman, S | 1 |
| Paucek, P | 1 |
| Garlid, KD | 1 |
| Gille, L | 1 |
| Staniek, K | 1 |
| Nohl, H | 1 |
2 reviews available for succinic acid and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
The role of succinate and ROS in reperfusion injury - A critical appraisal.
Topics: Animals; Electron Transport Complex I; Humans; Mitochondria, Heart; Mitochondrial Membrane Transport | 2017 |
Succinate metabolism: a new therapeutic target for myocardial reperfusion injury.
Topics: Animals; Cardiovascular Agents; Electron Transport; Electron Transport Complex I; Electron Transport | 2016 |
17 other studies available for succinic acid and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo.
Topics: Animals; Cardiotonic Agents; Cell Line; Disease Models, Animal; Esters; Female; Humans; Male; Malona | 2022 |
Mechanism of succinate efflux upon reperfusion of the ischaemic heart.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Female; Isolated Heart Preparation; Male; Metabolo | 2021 |
Succinate accumulation impairs cardiac pyruvate dehydrogenase activity through GRP91-dependent and independent signaling pathways: Therapeutic effects of ginsenoside Rb1.
Topics: Animals; Ginsenosides; Male; Mice; Mice, Inbred ICR; Myocardial Reperfusion Injury; Myocardium; Pyru | 2017 |
Metabolomic Profiling in Acute ST-Segment-Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia-Reperfusion Injury.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Coronary Angiography; Female; Follow-Up Studies; Humans; | 2018 |
Ischemic preconditioning protects against cardiac ischemia reperfusion injury without affecting succinate accumulation or oxidation.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Energy Metabolism; Ischemic Preconditioning, | 2018 |
Protection against cardiac ischemia-reperfusion injury by hypothermia and by inhibition of succinate accumulation and oxidation is additive.
Topics: Animals; Hypothermia, Induced; Male; Malonates; Myocardial Reperfusion Injury; Rabbits; Random Alloc | 2019 |
Exogenous nicotinamide adenine dinucleotide administration alleviates ischemia/reperfusion-induced oxidative injury in isolated rat hearts via Sirt5-SDH-succinate pathway.
Topics: Animals; Male; Malondialdehyde; Myocardial Reperfusion Injury; Myocardium; NAD; Oxidative Stress; Ra | 2019 |
[Protective effect of succinic acid on primary cardiomyocyte hypoxia/reoxygenation injury].
Topics: Animals; Apoptosis; Caspase 3; Cell Hypoxia; Cell Survival; Cells, Cultured; Female; Humans; Hypoxia | 2013 |
The cardioprotectant 3',4'-dihydroxyflavonol inhibits opening of the mitochondrial permeability transition pore after myocardial ischemia and reperfusion in rats.
Topics: Animals; Cardiotonic Agents; Flavonols; Malates; Male; Mitochondria, Heart; Mitochondrial Membrane T | 2014 |
Characterization of the cardiac succinylome and its role in ischemia-reperfusion injury.
Topics: Adenine Nucleotide Translocator 1; Animals; Electron Transport Chain Complex Proteins; Fatty Acids; | 2015 |
Not low hanging but still sweet: Metabolic proteomes in cardiovascular disease.
Topics: Animals; Female; Male; Myocardial Reperfusion Injury; Myocardium; Protein Processing, Post-Translati | 2016 |
Mitochondria respiration and susceptibility to ischemia-reperfusion injury in diabetic hearts.
Topics: Animals; Body Weight; Cell Respiration; Diabetes Mellitus, Experimental; Disease Susceptibility; Glu | 2003 |
Exercise training decreases rat heart mitochondria free radical generation but does not prevent Ca2+-induced dysfunction.
Topics: Adaptation, Physiological; Adenosine Diphosphate; Animals; Calcium; Catalase; Electron Transport Com | 2007 |
Postischemic administration of succinate reverses the impairment of oxidative phosphorylation after cardiac ischemia and reperfusion injury.
Topics: Adenosine Triphosphate; Animals; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Oxi | 1997 |
Cardioprotective effect of succinate against ischemia/reperfusion injury.
Topics: Animals; Antioxidants; Cardioplegic Solutions; Dose-Response Relationship, Drug; Heart; In Vitro Tec | 1998 |
Bioenergetic consequences of opening the ATP-sensitive K(+) channel of heart mitochondria.
Topics: Adenosine Triphosphate; Animals; Anions; Cell Respiration; Diazoxide; Energy Metabolism; Ion Channel | 2001 |
Effects of tocopheryl quinone on the heart: model experiments with xanthine oxidase, heart mitochondria, and isolated perfused rat hearts.
Topics: Animals; Antimycin A; Antioxidants; Cytochrome b Group; Electron Spin Resonance Spectroscopy; Electr | 2001 |