succinic acid has been researched along with Hereditary Optic Neuroretinopathy in 2 studies
Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "For example, Leber's hereditary optic neuropathy (LHON) results from one of three point mutations mtDNA coding for complex I components, but is only manifested in retinal ganglion cells (RGCs), a central neuron contained within the retina." | 1.35 | Differential production of superoxide by neuronal mitochondria. ( Hoegger, MJ; Levin, LA; Lieven, CJ, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baracca, A | 1 |
| Solaini, G | 1 |
| Sgarbi, G | 1 |
| Lenaz, G | 1 |
| Baruzzi, A | 1 |
| Schapira, AH | 1 |
| Martinuzzi, A | 1 |
| Carelli, V | 1 |
| Hoegger, MJ | 1 |
| Lieven, CJ | 1 |
| Levin, LA | 1 |
2 other studies available for succinic acid and Hereditary Optic Neuroretinopathy
| Article | Year |
|---|---|
Severe impairment of complex I-driven adenosine triphosphate synthesis in leber hereditary optic neuropathy cybrids.
Topics: Adenosine Triphosphate; Cells, Cultured; Citric Acid; DNA, Mitochondrial; Electron Transport Complex | 2005 |
Differential production of superoxide by neuronal mitochondria.
Topics: Animals; Cell Line; Electron Transport Complex I; Electron Transport Complex III; Energy Metabolism; | 2008 |