succinic acid has been researched along with Heart Disease, Ischemic in 15 studies
Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A mixture of mitochondrial substrates of succinic and malic acids more effectively than antihypoxant trimetazidine prevented functional and metabolic disorders in rat myocardium during acute ischemia: reduces T wave amplitude, QT interval, number and duration of arrhythmias, and restores oxidation-phosphorylation coupling." | 7.74 | Cardioprotective effects of trimetazidine and a combination of succinic and malic acids in acute myocardial ischemia. ( Chernyschova, GA; Khazanov, VA; Kiseliova, AA; Vasiliev, KY, 2008) |
| " We further showed that inhibition of succinate release and GPR91 signaling ameliorated oxygen-glucose deprivation-induced injury in cardiomyocytes and isoproterenol-induced myocardial ischemia injury in mice." | 3.88 | Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling. ( Li, J; Li, LZ; Liu, B; Liu, K; Liu, Q; Lu, YT; Qi, LW; Yang, YL; Yin, X; Zhang, L, 2018) |
| "A mixture of mitochondrial substrates of succinic and malic acids more effectively than antihypoxant trimetazidine prevented functional and metabolic disorders in rat myocardium during acute ischemia: reduces T wave amplitude, QT interval, number and duration of arrhythmias, and restores oxidation-phosphorylation coupling." | 3.74 | Cardioprotective effects of trimetazidine and a combination of succinic and malic acids in acute myocardial ischemia. ( Chernyschova, GA; Khazanov, VA; Kiseliova, AA; Vasiliev, KY, 2008) |
| " Besides its significant antiarrhythmic activity, ethacizin displayed a number of adverse cardiac effects, such as excessive negative inotropic and dromotropic ones." | 1.29 | [Possibilities of correcting adverse effects of anti-arrhythmia agents]. ( Bartashevich, VV; Galenko-Iaroshevskiĭ, PA; Kanorskiĭ, SG; Khankoeva, AI; Skibitskiĭ, VV; Uvarov, AV, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (40.00) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Ali, HR | 1 |
| Michel, CR | 1 |
| Lin, YH | 1 |
| McKinsey, TA | 1 |
| Jeong, MY | 1 |
| Ambardekar, AV | 1 |
| Cleveland, JC | 1 |
| Reisdorph, R | 1 |
| Reisdorph, N | 1 |
| Woulfe, KC | 1 |
| Fritz, KS | 1 |
| Zhang, J | 1 |
| Wang, YT | 1 |
| Miller, JH | 1 |
| Day, MM | 1 |
| Munger, JC | 1 |
| Brookes, PS | 1 |
| Lu, YT | 1 |
| Li, LZ | 1 |
| Yang, YL | 1 |
| Yin, X | 1 |
| Liu, Q | 1 |
| Zhang, L | 1 |
| Liu, K | 1 |
| Liu, B | 1 |
| Li, J | 1 |
| Qi, LW | 1 |
| Khazanov, VA | 1 |
| Kiseliova, AA | 1 |
| Vasiliev, KY | 1 |
| Chernyschova, GA | 1 |
| Kurian, GA | 1 |
| Berenshtein, E | 1 |
| Kakhlon, O | 1 |
| Chevion, M | 1 |
| Monteiro, P | 1 |
| Duarte, A | 1 |
| Moreno, A | 1 |
| Gonçalves, L | 1 |
| Providência, LA | 1 |
| Lashin, O | 1 |
| Romani, A | 1 |
| Pasdois, P | 1 |
| Beauvoit, B | 1 |
| Tariosse, L | 1 |
| Vinassa, B | 1 |
| Bonoron-Adèle, S | 1 |
| Santos, PD | 1 |
| Chen, Q | 1 |
| Moghaddas, S | 1 |
| Hoppel, CL | 1 |
| Lesnefsky, EJ | 1 |
| Kakinuma, Y | 1 |
| Matsubara, T | 2 |
| Hashimoto, T | 1 |
| Sakamoto, N | 2 |
| Kato, K | 1 |
| Skibitskiĭ, VV | 2 |
| Galenko-Iaroshevskiĭ, PA | 1 |
| Kanorskiĭ, SG | 1 |
| Khankoeva, AI | 1 |
| Bartashevich, VV | 1 |
| Uvarov, AV | 1 |
| Borutaite, V | 1 |
| Morkuniene, R | 1 |
| Budriunaite, A | 1 |
| Krasauskaite, D | 1 |
| Ryselis, S | 1 |
| Toleikis, A | 1 |
| Brown, GC | 1 |
| Cairns, CB | 1 |
| Ferroggiaro, AA | 1 |
| Walther, JM | 1 |
| Harken, AH | 1 |
| Banerjee, A | 1 |
1 review available for succinic acid and Heart Disease, Ischemic
| Article | Year |
|---|---|
Myocardial metabolic markers of total ischemia in vitro.
Topics: Animals; Biomarkers; Dogs; Female; Lactates; Lactic Acid; Male; Myocardial Ischemia; Phosphates; Suc | 1994 |
14 other studies available for succinic acid and Heart Disease, Ischemic
| Article | Year |
|---|---|
Defining decreased protein succinylation of failing human cardiac myofibrils in ischemic cardiomyopathy.
Topics: Acylation; Cardiomyopathies; Heart Failure; Humans; Lysine; Methylation; Middle Aged; Mitochondrial | 2020 |
Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity.
Topics: Animals; Aspartic Acid; Autophagy; Citric Acid Cycle; Electron Transport Complex II; Energy Metaboli | 2018 |
Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling.
Topics: Amino Acid Sequence; Animals; Animals, Newborn; Apoptosis; Dynamins; Enzyme Activation; Extracellula | 2018 |
Cardioprotective effects of trimetazidine and a combination of succinic and malic acids in acute myocardial ischemia.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiotonic Agents; Coronary Occlusion; Drug | 2008 |
Energy status determines the distinct biochemical and physiological behavior of interfibrillar and sub-sarcolemmal mitochondria.
Topics: Animals; Cell Respiration; Energy Metabolism; Glutamic Acid; Ischemic Preconditioning; Malates; Male | 2012 |
Pyruvate improves mitochondrial bioenergetics in an ex-vivo animal model of myocardial ischemia.
Topics: Animals; Ascorbic Acid; Chemotherapy, Cancer, Regional Perfusion; Female; Glutamic Acid; Intracellul | 2003 |
Mitochondria respiration and susceptibility to ischemia-reperfusion injury in diabetic hearts.
Topics: Animals; Body Weight; Cell Respiration; Diabetes Mellitus, Experimental; Disease Susceptibility; Glu | 2003 |
MitoK(ATP)-dependent changes in mitochondrial volume and in complex II activity during ischemic and pharmacological preconditioning of Langendorff-perfused rat heart.
Topics: Adenosine Diphosphate; Animals; Antihypertensive Agents; Cell Respiration; Decanoic Acids; Diazoxide | 2006 |
Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria.
Topics: Animals; Electron Transport; Electron Transport Chain Complex Proteins; Electron Transport Complex I | 2008 |
Correlation between myocardial blood flow and tissue succinate during acute ischemia.
Topics: Acute Disease; Animals; Biomarkers; Coronary Circulation; Dogs; Female; Lactates; Lactic Acid; Male; | 1994 |
[Possibilities of correcting adverse effects of anti-arrhythmia agents].
Topics: Anti-Arrhythmia Agents; Antidepressive Agents; Arrhythmias, Cardiac; Benzamides; Drug Therapy, Combi | 1996 |
Kinetic analysis of changes in activity of heart mitochondrial oxidative phosphorylation system induced by ischemia.
Topics: Animals; Cytochrome c Group; Electron Transport; Fatty Acids; Heart; Kinetics; Male; Malonates; Memb | 1996 |
Postischemic administration of succinate reverses the impairment of oxidative phosphorylation after cardiac ischemia and reperfusion injury.
Topics: Adenosine Triphosphate; Animals; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Oxi | 1997 |
[The potentials of combined anti-arrhythmia therapy with the use of neuroactive amino acids in patients with ischemic heart disease].
Topics: Aged; Angina Pectoris; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiac Complexes, Premature; Dr | 1992 |