succinic acid has been researched along with Experimental Neoplasms in 10 studies
Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The oral LD50 was greater than 8 g/kg body weight." | 1.28 | Lack of toxicity/carcinogenicity of monosodium succinate in F344 rats. ( Hayashi, Y; Kodama, Y; Maekawa, A; Matsushima, Y; Nagaoka, T; Ogasawara, H; Onodera, H; Shibutani, M; Todate, A, 1990) |
| "Phenformin treatment inhibited the development of induced tumors in the nervous system and kidneys, significantly decreased the total incidence and multiplicity of these tumors, the incidence of brain and spinal cord tumors and multiplicity of brain tumors." | 1.27 | [Effect of phenformin and succinic acid on the transplacental carcinogenic effect of N-nitroso-N-ethylurea in rats]. ( Aleksandrov, VA; Bespalov, VG, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ekladious, I | 1 |
| Liu, R | 1 |
| Varongchayakul, N | 1 |
| Mejia Cruz, LA | 1 |
| Todd, DA | 1 |
| Zhang, H | 1 |
| Oberlies, NH | 1 |
| Padera, RF | 1 |
| Colson, YL | 1 |
| Grinstaff, MW | 1 |
| Li, F | 1 |
| He, X | 2 |
| Ye, D | 1 |
| Lin, Y | 1 |
| Yu, H | 1 |
| Yao, C | 1 |
| Huang, L | 1 |
| Zhang, J | 1 |
| Wang, F | 1 |
| Xu, S | 1 |
| Wu, X | 1 |
| Liu, L | 1 |
| Yang, C | 1 |
| Shi, J | 1 |
| Liu, J | 1 |
| Qu, Y | 1 |
| Guo, F | 1 |
| Zhao, J | 1 |
| Xu, W | 1 |
| Zhao, S | 1 |
| Gasparre, G | 1 |
| Kurelac, I | 1 |
| Capristo, M | 1 |
| Iommarini, L | 1 |
| Ghelli, A | 1 |
| Ceccarelli, C | 1 |
| Nicoletti, G | 1 |
| Nanni, P | 1 |
| De Giovanni, C | 1 |
| Scotlandi, K | 1 |
| Betts, CM | 1 |
| Carelli, V | 1 |
| Lollini, PL | 1 |
| Romeo, G | 1 |
| Rugolo, M | 1 |
| Porcelli, AM | 1 |
| MIURA, Y | 1 |
| ASO, Y | 1 |
| MASHIMA, Y | 1 |
| NAGATA, I | 1 |
| Popovich, IG | 1 |
| Zabezhinskii, MA | 1 |
| Anisimov, VN | 1 |
| Kovalenko, AL | 1 |
| Petrov, AY | 1 |
| Semenchenko, AV | 1 |
| Yashin, AI | 1 |
| Biaglow, J | 1 |
| Dewhirst, M | 1 |
| Leeper, D | 1 |
| Burd, R | 1 |
| Tuttle, S | 1 |
| Biaglow, JE | 1 |
| Varnes, ME | 1 |
| Jacobson, B | 1 |
| Suit, HD | 1 |
| Fonnesu, A | 1 |
| Capaccioli, S | 1 |
| Cini-Neri, G | 1 |
| Bespalov, VG | 1 |
| Aleksandrov, VA | 1 |
| Maekawa, A | 1 |
| Todate, A | 1 |
| Onodera, H | 1 |
| Matsushima, Y | 1 |
| Nagaoka, T | 1 |
| Shibutani, M | 1 |
| Ogasawara, H | 1 |
| Kodama, Y | 1 |
| Hayashi, Y | 1 |
10 other studies available for succinic acid and Experimental Neoplasms
| Article | Year |
|---|---|
Reinforcement of polymeric nanoassemblies for ultra-high drug loadings, modulation of stiffness and release kinetics, and sustained therapeutic efficacy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Carriers; Drug Liberation; Kineti | 2018 |
NADP(+)-IDH Mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance.
Topics: Animals; Apoptosis; Cell Line, Tumor; Glutarates; HEK293 Cells; Humans; Isocitrate Dehydrogenase; Mi | 2015 |
A mutation threshold distinguishes the antitumorigenic effects of the mitochondrial gene MTND1, an oncojanus function.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Transformation, Neoplastic; Electron Transport Complex I; | 2011 |
Studies on the metabolism of rat-ascites-tumor with nitrogen mustard sensitive and resistant strains. VII. Effect of ubiquinone a vitamin K3 on succinate- and alpha-glyceropnosphate-neotetrazolium reductase.
Topics: Animals; Ascites; Carcinoma, Hepatocellular; Coenzymes; Electron Transport Complex II; Liver Neoplas | 1962 |
Effect of neuronol on lifespan and development of spontaneous tumors in SAMP-1 mice with genetically accelerated aging.
Topics: Aging; Animals; Anticarcinogenic Agents; Drug Evaluation, Preclinical; Female; Histiocytoma, Benign | 2003 |
Factors controlling oxygen utilization.
Topics: 3-Iodobenzylguanidine; Animals; Cell Line, Tumor; Diffusion; Female; Glioma; Glucose; Glutamine; Mal | 2005 |
Control of oxygen utilization in vitro and in vivo: implications for radiotherapy of tumors.
Topics: Animals; Cricetinae; Ethylmaleimide; Glutamates; Glutamic Acid; Humans; In Vitro Techniques; Mice; N | 1984 |
Effects of succinate on amino acid incorporation into protein during chemical carcinogenesis.
Topics: Amino Acids; Animals; Carcinogens; Leucine; Liver; Male; Neoplasm Proteins; Neoplasms, Experimental; | 1984 |
[Effect of phenformin and succinic acid on the transplacental carcinogenic effect of N-nitroso-N-ethylurea in rats].
Topics: Animals; Ethylnitrosourea; Female; Kidney Neoplasms; Maternal-Fetal Exchange; Neoplasms, Experimenta | 1984 |
Lack of toxicity/carcinogenicity of monosodium succinate in F344 rats.
Topics: Animals; Body Weight; Carcinogenicity Tests; Drinking; Female; Food Additives; Lethal Dose 50; Male; | 1990 |