succinic acid has been researched along with Electron Transport Chain Deficiencies, Mitochondrial in 12 studies
Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Liver is a target organ in many mitochondrial disorders, especially if the complex III assembly factor BCS1L is mutated." | 1.38 | Metabolite profiles reveal energy failure and impaired beta-oxidation in liver of mice with complex III deficiency due to a BCS1L mutation. ( Davoudi, M; Enot, DP; Fellman, V; Karikoski, R; Keller, M; Kotarsky, H; Levéen, P, 2012) |
| "Diagnosis of mitochondrial disorders usually requires a muscle biopsy to examine mitochondrial function." | 1.33 | Measurement of the energy-generating capacity of human muscle mitochondria: diagnostic procedure and application to human pathology. ( Janssen, AJ; Morava, E; Rodenburg, RJ; Ruitenbeek, W; Sengers, RC; Smeitink, JA; Trijbels, FJ; van den Heuvel, LP; van Engelen, BG; Wintjes, LT, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (58.33) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miller, DM | 1 |
| Singh, IN | 1 |
| Wang, JA | 1 |
| Hall, ED | 1 |
| Roe, CR | 1 |
| Brunengraber, H | 1 |
| Ehinger, JK | 1 |
| Piel, S | 1 |
| Ford, R | 1 |
| Karlsson, M | 1 |
| Sjövall, F | 1 |
| Frostner, EÅ | 1 |
| Morota, S | 1 |
| Taylor, RW | 1 |
| Turnbull, DM | 1 |
| Cornell, C | 1 |
| Moss, SJ | 1 |
| Metzsch, C | 1 |
| Hansson, MJ | 1 |
| Fliri, H | 1 |
| Elmér, E | 1 |
| Thaveau, F | 1 |
| Zoll, J | 1 |
| Bouitbir, J | 1 |
| Ribera, F | 1 |
| Di Marco, P | 1 |
| Chakfe, N | 1 |
| Kretz, JG | 1 |
| Piquard, F | 1 |
| Geny, B | 1 |
| Orsucci, D | 1 |
| Filosto, M | 1 |
| Siciliano, G | 1 |
| Mancuso, M | 1 |
| Schiff, M | 1 |
| Bénit, P | 2 |
| El-Khoury, R | 1 |
| Schlemmer, D | 1 |
| Benoist, JF | 1 |
| Rustin, P | 3 |
| Kotarsky, H | 1 |
| Keller, M | 1 |
| Davoudi, M | 1 |
| Levéen, P | 1 |
| Karikoski, R | 1 |
| Enot, DP | 1 |
| Fellman, V | 1 |
| Brière, JJ | 1 |
| Chrétien, D | 1 |
| Janssen, AJ | 1 |
| Trijbels, FJ | 1 |
| Sengers, RC | 1 |
| Wintjes, LT | 1 |
| Ruitenbeek, W | 1 |
| Smeitink, JA | 1 |
| Morava, E | 1 |
| van Engelen, BG | 1 |
| van den Heuvel, LP | 1 |
| Rodenburg, RJ | 1 |
| Vengerovskii, AI | 1 |
| Khazanov, VA | 1 |
| Eskina, KA | 1 |
| Vasilyev, KY | 1 |
| Rötig, A | 1 |
| Kuroda, Y | 1 |
| Naito, E | 1 |
| Touda, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 2A/2B Placebo-controlled Randomised Clinical Trial to Test the Ability of Triheptanoin to Protect Primary Airway Epithelial Cells Obtained From Participants With Ataxia-telangiectasia Against Death Induced by Glucose Deprivation[NCT04513002] | Phase 2 | 30 participants (Actual) | Interventional | 2022-03-15 | Completed | ||
| Mitochondrial Targeted Biofuels as Countermeasures Against Chemical Threats[NCT03597438] | 700 participants (Anticipated) | Observational | 2018-05-07 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for succinic acid and Electron Transport Chain Deficiencies, Mitochondrial
| Article | Year |
|---|---|
Electron transfer mediators and other metabolites and cofactors in the treatment of mitochondrial dysfunction.
Topics: Acidosis, Lactic; Animals; Antioxidants; Carnitine; Creatine; Dietary Supplements; Electron Transpor | 2009 |
Respiratory chain defects: what do we know for sure about their consequences in vivo?
Topics: Adenosine Triphosphate; Cell Respiration; Humans; Mitochondria; Mitochondrial Diseases; Signal Trans | 2004 |
Inborn errors of complex II--unusual human mitochondrial diseases.
Topics: Citric Acid Cycle; Electron Transport Complex II; Flavoproteins; Fumarates; Humans; Metabolism, Inbo | 2002 |
[Drug therapy for mitochondrial diseases].
Topics: Carnitine; Coenzymes; Cytochrome c Group; Cytochromes c; Dichloroacetic Acid; Drug Combinations; Dru | 2002 |
8 other studies available for succinic acid and Electron Transport Chain Deficiencies, Mitochondrial
| Article | Year |
|---|---|
Nrf2-ARE activator carnosic acid decreases mitochondrial dysfunction, oxidative damage and neuronal cytoskeletal degradation following traumatic brain injury in mice.
Topics: Abietanes; Adenosine Diphosphate; Aldehydes; Analysis of Variance; Animals; Antioxidants; Brain; Bra | 2015 |
Anaplerotic treatment of long-chain fat oxidation disorders with triheptanoin: Review of 15 years Experience.
Topics: Administration, Oral; Adolescent; Adult; Carnitine; Child; Child, Preschool; Citric Acid; Fatty Acid | 2015 |
Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency.
Topics: Cell Membrane Permeability; Cell Respiration; Drug Discovery; Drug Evaluation, Preclinical; Electron | 2016 |
Contralateral leg as a control during skeletal muscle ischemia-reperfusion.
Topics: Animals; Ascorbic Acid; Cell Respiration; Electron Transport Chain Complex Proteins; Glutamic Acid; | 2009 |
Mouse studies to shape clinical trials for mitochondrial diseases: high fat diet in Harlequin mice.
Topics: Animals; Atrophy; Carnitine; Cattle; Cell Death; Cell Respiration; Cerebellum; Clinical Trials as To | 2011 |
Metabolite profiles reveal energy failure and impaired beta-oxidation in liver of mice with complex III deficiency due to a BCS1L mutation.
Topics: Adenosine Monophosphate; Animals; Antioxidants; ATPases Associated with Diverse Cellular Activities; | 2012 |
Measurement of the energy-generating capacity of human muscle mitochondria: diagnostic procedure and application to human pathology.
Topics: Adenosine Triphosphate; Adolescent; Adult; Biopsy; Carbon Radioisotopes; Carnitine; Child; Child, Pr | 2006 |
Effects of silymarin (hepatoprotector) and succinic acid (bioenergy regulator) on metabolic disorders in experimental diabetes mellitus.
Topics: Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Lipid Peroxidation; Male; Mice | 2007 |