succinic acid has been researched along with Diabetes Mellitus, Adult-Onset in 16 studies
Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Succinic Acid has some positive biological properties." | 5.31 | [Diabetes mellitus in the elderly: succinic acid compounds in treating diabetic neuropathies]. ( Belikova, TV; Odin, VI; Pushkova, ES, 2002) |
| "Obesity was associated with elevated levels of circulating succinate concomitant with impaired glucose metabolism." | 2.87 | Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota. ( Andrés-Lacueva, C; Bernal, R; Ceperuelo-Mallafré, V; Fernández-Real, JM; Fernández-Veledo, S; Gomez-Huelgas, R; Keiran, N; Moya, A; Pérez-Brocal, V; Queipo-Ortuño, MI; Sabater, M; Serena, C; Tinahones, FJ; Urpi-Sarda, M; Vendrell, J, 2018) |
| "Metformin is used to treat type 2 diabetes." | 1.51 | Metformin activates KDM2A to reduce rRNA transcription and cell proliferation by dual regulation of AMPK activity and intracellular succinate level. ( Konishi, A; Obinata, H; Tanaka, Y; Tsuneoka, M, 2019) |
| "Insulin sensitivity was determined with the isoglycaemic-hyperinsulinaemic clamp technique." | 1.37 | Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes. ( Andersen, JL; Dela, F; Hansen, CN; Helge, JW; Hey-Mogensen, M; Larsen, S; Madsbad, S; Stride, N; Worm, D, 2011) |
| "Although obesity is a risk factor for development of type 2 diabetes and chemical modification of proteins by advanced glycoxidation and lipoxidation end products is implicated in the development of diabetic complications, little is known about the chemical modification of proteins in adipocytes or adipose tissue." | 1.34 | Succination of protein thiols during adipocyte maturation: a biomarker of mitochondrial stress. ( Baatz, JE; Baynes, JW; Bethard, J; Blatnik, M; Brock, JW; Frizzell, N; Nagai, R; Thorpe, SR; Walla, MD, 2007) |
| "Succinic Acid has some positive biological properties." | 1.31 | [Diabetes mellitus in the elderly: succinic acid compounds in treating diabetic neuropathies]. ( Belikova, TV; Odin, VI; Pushkova, ES, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 7 (43.75) | 24.3611 |
| 2020's | 5 (31.25) | 2.80 |
| Authors | Studies |
|---|---|
| Kharitonova, T | 1 |
| Shvarts, YG | 1 |
| Verbovoy, AF | 1 |
| Orlova, NS | 1 |
| Puzyreva, VP | 1 |
| Strokov, IA | 1 |
| Huber-Ruano, I | 1 |
| Calvo, E | 1 |
| Mayneris-Perxachs, J | 1 |
| Rodríguez-Peña, MM | 1 |
| Ceperuelo-Mallafré, V | 2 |
| Cedó, L | 1 |
| Núñez-Roa, C | 1 |
| Miro-Blanch, J | 1 |
| Arnoriaga-Rodríguez, M | 1 |
| Balvay, A | 1 |
| Maudet, C | 1 |
| García-Roves, P | 1 |
| Yanes, O | 1 |
| Rabot, S | 1 |
| Grimaud, GM | 1 |
| De Prisco, A | 1 |
| Amoruso, A | 1 |
| Fernández-Real, JM | 2 |
| Vendrell, J | 2 |
| Fernández-Veledo, S | 2 |
| Pu, M | 1 |
| Zhang, J | 4 |
| Zeng, Y | 1 |
| Hong, F | 1 |
| Qi, W | 1 |
| Yang, X | 3 |
| Gao, G | 1 |
| Zhou, T | 2 |
| Wang, T | 2 |
| Wang, M | 1 |
| Liu, L | 3 |
| Xie, F | 1 |
| Wu, X | 2 |
| Li, L | 1 |
| Ji, J | 1 |
| Wu, D | 4 |
| Tanaka, Y | 1 |
| Konishi, A | 1 |
| Obinata, H | 1 |
| Tsuneoka, M | 1 |
| Nguépy Keubo, FR | 1 |
| Mboua, PC | 1 |
| Djifack Tadongfack, T | 1 |
| Fokouong Tchoffo, E | 1 |
| Tasson Tatang, C | 1 |
| Ide Zeuna, J | 1 |
| Noupoue, EM | 1 |
| Tsoplifack, CB | 1 |
| Folefack, GO | 1 |
| Kettani, M | 1 |
| Bandelier, P | 1 |
| Huo, J | 1 |
| Li, H | 4 |
| Yu, D | 1 |
| Arulsamy, N | 1 |
| AlAbbad, S | 1 |
| Sardot, T | 1 |
| Lekashvili, O | 1 |
| Decato, D | 1 |
| Lelj, F | 1 |
| Alexander Ross, JB | 1 |
| Rosenberg, E | 1 |
| Nazir, H | 1 |
| Muthuswamy, N | 1 |
| Louis, C | 1 |
| Jose, S | 1 |
| Prakash, J | 1 |
| Buan, MEM | 1 |
| Flox, C | 1 |
| Chavan, S | 1 |
| Shi, X | 1 |
| Kauranen, P | 1 |
| Kallio, T | 1 |
| Maia, G | 1 |
| Tammeveski, K | 1 |
| Lymperopoulos, N | 1 |
| Carcadea, E | 1 |
| Veziroglu, E | 1 |
| Iranzo, A | 1 |
| M Kannan, A | 1 |
| Arunamata, A | 1 |
| Tacy, TA | 1 |
| Kache, S | 1 |
| Mainwaring, RD | 1 |
| Ma, M | 1 |
| Maeda, K | 1 |
| Punn, R | 1 |
| Noguchi, S | 1 |
| Hahn, S | 3 |
| Iwasa, Y | 3 |
| Ling, J | 2 |
| Voccio, JP | 2 |
| Kim, Y | 3 |
| Song, J | 3 |
| Bascuñán, J | 2 |
| Chu, Y | 1 |
| Tomita, M | 1 |
| Cazorla, M | 1 |
| Herrera, E | 1 |
| Palomeque, E | 1 |
| Saud, N | 1 |
| Hoplock, LB | 1 |
| Lobchuk, MM | 1 |
| Lemoine, J | 1 |
| Li, X | 12 |
| Henson, MA | 1 |
| Unsihuay, D | 1 |
| Qiu, J | 1 |
| Swaroop, S | 1 |
| Nagornov, KO | 1 |
| Kozhinov, AN | 1 |
| Tsybin, YO | 1 |
| Kuang, S | 1 |
| Laskin, J | 1 |
| Zin, NNINM | 1 |
| Mohamad, MN | 1 |
| Roslan, K | 1 |
| Abdul Wafi, S | 1 |
| Abdul Moin, NI | 1 |
| Alias, A | 1 |
| Zakaria, Y | 1 |
| Abu-Bakar, N | 1 |
| Naveed, A | 1 |
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| Huang, W | 1 |
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| Hossein Rashidi, B | 1 |
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| Ghazimirsaeed, ST | 1 |
| Shahrokh Tehraninezhad, E | 1 |
| Keikha, F | 1 |
| Eslami, B | 1 |
| Ghazimirsaeed, SM | 1 |
| Jafarabadi, M | 1 |
| Silvani, Y | 1 |
| Lovita, AND | 1 |
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| Rahman, MM | 1 |
| Pangarah, CA | 1 |
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| Hopman, WM | 1 |
| Vanderpuye, V | 1 |
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| Chen, Y | 3 |
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| Shan, A | 1 |
| Zhao, H | 2 |
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| Ma, Q | 1 |
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| Li, Y | 5 |
| Xue, F | 1 |
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| Anastassiadou, M | 1 |
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| Brancato, A | 1 |
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| Greco, L | 1 |
| Jarrah, S | 1 |
| Kazocina, A | 1 |
| Leuschner, R | 1 |
| Magrans, JO | 1 |
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| Nave, S | 1 |
| Pedersen, R | 1 |
| Reich, H | 1 |
| Rojas, A | 1 |
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| Theobald, A | 1 |
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| Li, J | 7 |
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| Wang, YS | 1 |
| Wang, C | 3 |
| Zhou, X | 2 |
| Wang, W | 1 |
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| Hou, J | 1 |
| Zhang, A | 1 |
| Lv, B | 1 |
| Gao, C | 1 |
| Pang, D | 1 |
| Lu, K | 1 |
| Ahmad, NH | 1 |
| Wang, L | 1 |
| Zhu, J | 2 |
| Zhang, L | 2 |
| Zhuang, T | 1 |
| Tu, J | 1 |
| Zhao, Z | 1 |
| Qu, Y | 1 |
| Yao, H | 1 |
| Wang, X | 5 |
| Lee, DF | 1 |
| Shen, J | 3 |
| Wen, L | 1 |
| Huang, G | 2 |
| Xie, X | 1 |
| Zhao, Q | 1 |
| Hu, W | 1 |
| Zhang, Y | 4 |
| Lu, J | 2 |
| Li, M | 1 |
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| Wu, W | 1 |
| Du, F | 1 |
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| Kang, KW | 1 |
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| Pajuelo-Lozano, N | 1 |
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| Logotheti, S | 1 |
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| Gupta, SK | 1 |
| Richter, C | 1 |
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| Söhnchen, C | 1 |
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| Alpers, M | 1 |
| Singh, KP | 1 |
| Wolkenhauer, O | 1 |
| Heckl, D | 1 |
| Spitschak, A | 1 |
| Pützer, BM | 1 |
| Liao, Y | 1 |
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| Kong, X | 1 |
| Li, S | 1 |
| Zhang, M | 4 |
| Zhang, H | 1 |
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| Liang, C | 1 |
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| Hu, J | 2 |
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| Liu, Y | 4 |
| Mi, Y | 1 |
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| Xi, D | 1 |
| Yan, W | 1 |
| Luo, X | 1 |
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| Chang, X | 2 |
| Zhang, T | 3 |
| Wang, Q | 2 |
| Rathore, MG | 1 |
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| Chen, H | 1 |
| Shin, SH | 1 |
| Ma, WY | 1 |
| Bode, AM | 1 |
| Dong, Z | 1 |
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| Liu, C | 3 |
| Gao, F | 1 |
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| Zhang, X | 4 |
| Cai, X | 1 |
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| Hou, Y | 3 |
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| Shi, Y | 1 |
| Ying, S | 1 |
| Tan, M | 1 |
| Feng, G | 1 |
| Kuang, Y | 1 |
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| Zhu, ZQ | 1 |
| Tang, HX | 1 |
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| Sahebkar, A | 1 |
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| Kouvari, M | 1 |
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| Andronikos, P | 1 |
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| Efraimidis, P | 1 |
| Georgiopoulos, A | 1 |
| Gerakiou, K | 1 |
| Grigoriadou-Skouta, E | 1 |
| Grigoropoulos, P | 1 |
| Hatzopoulos, D | 1 |
| Kartalis, A | 1 |
| Lyras, A | 1 |
| Markatos, G | 1 |
| Mikrogeorgiou, A | 1 |
| Myroforou, I | 1 |
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| Pavlidis, P | 1 |
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| Thomaidis, K | 1 |
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| Xi, J | 1 |
| Li, C | 1 |
| Chen, W | 2 |
| Hu, X | 1 |
| Zhang, F | 1 |
| Wei, H | 1 |
| Wang, Z | 1 |
| Gurzu, S | 1 |
| Jung, I | 1 |
| Sugimura, H | 2 |
| Stefan-van Staden, RI | 1 |
| Yamada, H | 1 |
| Natsume, H | 1 |
| Iwashita, Y | 1 |
| Szodorai, R | 1 |
| Szederjesi, J | 1 |
| Yari, D | 1 |
| Ehsanbakhsh, Z | 1 |
| Validad, MH | 1 |
| Langroudi, FH | 1 |
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| Hassanpour, K | 1 |
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| Mets-Halgrimson, R | 1 |
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| Solis Condor, R | 1 |
| Efendi, F | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multicenter, Double-blind, Placebo-controlled Randomized Clinical Trial of Efficacy and Safety of the Drug Cytoflavin®, Administered Intravenously Followed by Oral Intake, in Patients With Diabetic Polyneuropathy[NCT04649203] | Phase 3 | 216 participants (Actual) | Interventional | 2020-11-25 | Completed | ||
| LIFESTAT - Living With Statins, a Cross Sectional Study on the Impact of Cholesterol Lowering Drugs on Health, Lifestyle and Well-being[NCT02250677] | 75 participants (Actual) | Observational | 2014-04-30 | Completed | |||
| Living With Statins - The Impact of Cholesterol Lowering Drugs on Health, Lifestyle and Well-being[NCT02796378] | Phase 4 | 30 participants (Anticipated) | Interventional | 2016-06-30 | Active, not recruiting | ||
| Living With Statins - The Impact of Cholesterol Lowering Drugs on Health, Lifestyle and Well-being[NCT02255682] | Phase 4 | 35 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for succinic acid and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Metabolic control of renin secretion.
Topics: Animals; Diabetes Mellitus, Type 2; Humans; Receptors, G-Protein-Coupled; Renin; Renin-Angiotensin S | 2013 |
3 trials available for succinic acid and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Efficacy and safety of the combined metabolic medication, containing inosine, nicotinamide, riboflavin and succinic acid, for the treatment of diabetic neuropathy: a multicenter randomized, double-blind, placebo-controlled parallel group clinical trial (C
Topics: Antioxidants; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Humans; Inosine; Male; Niaci | 2022 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota.
Topics: Adult; Aged; Bacteria; Biomarkers; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Gastr | 2018 |
12 other studies available for succinic acid and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Orally administered Odoribacter laneus improves glucose control and inflammatory profile in obese mice by depleting circulating succinate.
Topics: Animals; Bacteroidetes; Blood Glucose; Diabetes Mellitus, Type 2; Diet, High-Fat; Humans; Inflammati | 2022 |
Succinate-SUCNR1 induces renal tubular cell apoptosis.
Topics: Animals; Apoptosis; Diabetes Mellitus, Type 2; Epithelial Cells; Kidney; Mice; Receptors, G-Protein- | 2023 |
Lower serum branched-chain amino acid catabolic intermediates are predictive signatures specific to patients with diabetic foot.
Topics: Amino Acids, Branched-Chain; Diabetes Mellitus, Type 2; Diabetic Foot; Humans; Metabolomics; Succini | 2023 |
Metformin activates KDM2A to reduce rRNA transcription and cell proliferation by dual regulation of AMPK activity and intracellular succinate level.
Topics: AMP-Activated Protein Kinases; Cell Line, Tumor; Cell Proliferation; Diabetes Mellitus, Type 2; DNA, | 2019 |
Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis.
Topics: Animals; Bone Marrow Cells; Bone Resorption; Cell Differentiation; Cell Line; Citric Acid Cycle; Dia | 2017 |
Getting a Taste for Parasites in the Gut.
Topics: Animals; Diabetes Mellitus, Type 2; Intestines; Parasites; Succinic Acid; Taste | 2018 |
Identification of protein succination as a novel modification of tubulin.
Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue; Animals; Brain; Cattle; Cell Proliferation; Culture Media; | 2014 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
Succination of protein thiols during adipocyte maturation: a biomarker of mitochondrial stress.
Topics: 3T3 Cells; Adipocytes; Adipogenesis; Adipose Tissue; Animals; Biomarkers; Cell Differentiation; Citr | 2007 |
Deficiency of pyruvate dehydrogenase activity in pancreatic islets of diabetic GK rats.
Topics: Acetates; Animals; Diabetes Mellitus, Type 2; Epoxy Compounds; Female; Glucose; Hypoglycemic Agents; | 1995 |
Metabolism of [1,3-(13)C]glycerol-1,2,3-tris(methylsuccinate) and glycerol-1,2,3-tris(methyl[2,3-(13)C]succinate) in hepatocytes from Goto-Kakizaki rats.
Topics: Animals; Carbon Isotopes; Cells, Cultured; Chloride Channels; Diabetes Mellitus, Type 2; Disease Mod | 1999 |
[Diabetes mellitus in the elderly: succinic acid compounds in treating diabetic neuropathies].
Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Humans; Male; Middle | 2002 |