succinic acid has been researched along with Colitis in 11 studies
Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.
Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| " After induction of colitis, rats were treated with vehicle (dextran solution), mesalasine (120 mg/kg), budesonide suspension (300 microg/kg) and BSD-70 (equivalent to 300 microg/kg of budesonide), prednisolon (4 mg/kg), hydrocortisone acetate enema (20 mg/kg), and 5-ASA enema (Asacol) (400 mg/kg) for 5 days and then colon macroscopic and microscopic sections were examined for inflammatory response." | 7.76 | Effectiveness of budesonide-succinate-dextran conjugate as a novel prodrug of budesonide against acetic acid-induced colitis in rats. ( Ahmadi, F; Dorkoosh, F; Emami, J; Fassihi, A; Mahzouni, P; Minaiyan, M; Tavakoli, N; Varshosaz, J, 2010) |
| "As we consider succinic acid to be an exacerbating factor in ulcerative colitis, we investigated its influence on rat colonic mucosa in terms of mucosal blood flow and superoxide generation." | 7.69 | Mucosal blood flow and generation of superoxide in rat experimental colitis induced by succinic acid. ( Fukui, S; Satomi, M; Shimoyama, T; Tamura, K; Yamamura, M, 1997) |
| " After induction of colitis, rats were treated with vehicle (dextran solution), mesalasine (120 mg/kg), budesonide suspension (300 microg/kg) and BSD-70 (equivalent to 300 microg/kg of budesonide), prednisolon (4 mg/kg), hydrocortisone acetate enema (20 mg/kg), and 5-ASA enema (Asacol) (400 mg/kg) for 5 days and then colon macroscopic and microscopic sections were examined for inflammatory response." | 3.76 | Effectiveness of budesonide-succinate-dextran conjugate as a novel prodrug of budesonide against acetic acid-induced colitis in rats. ( Ahmadi, F; Dorkoosh, F; Emami, J; Fassihi, A; Mahzouni, P; Minaiyan, M; Tavakoli, N; Varshosaz, J, 2010) |
| "Our previous studies showed a low oral bioavailability and a predominant distribution of major XLP ingredients in the gut." | 1.91 | Xianglian pill modulates gut microbial production of succinate and induces regulatory T cells to alleviate ulcerative colitis in rats. ( Chen, FL; Deng, XH; Hu, YX; Liu, CS; Luo, ZY; Qiu, CW, 2023) |
| "There is an increased risk of colon cancer associated with inflammatory bowel disease (IBD)." | 1.91 | Refined fiber inulin promotes inflammation-associated colon tumorigenesis by modulating microbial succinate production. ( Castro, R; Hao, F; Neupane, R; Patterson, AD; Paudel, D; Prabhu, KS; Singh, V; Tian, S; Tiwari, AK, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 3 (27.27) | 2.80 |
| Authors | Studies |
|---|---|
| Fujiwara, H | 1 |
| Seike, K | 1 |
| Brooks, MD | 1 |
| Mathew, AV | 1 |
| Kovalenko, I | 1 |
| Pal, A | 1 |
| Lee, HJ | 1 |
| Peltier, D | 1 |
| Kim, S | 1 |
| Liu, C | 1 |
| Oravecz-Wilson, K | 1 |
| Li, L | 1 |
| Sun, Y | 1 |
| Byun, J | 1 |
| Maeda, Y | 1 |
| Wicha, MS | 1 |
| Saunders, TL | 1 |
| Rehemtulla, A | 1 |
| Lyssiotis, CA | 1 |
| Pennathur, S | 1 |
| Reddy, P | 1 |
| Liu, CS | 2 |
| Hu, YX | 2 |
| Luo, ZY | 2 |
| Qiu, CW | 2 |
| Deng, XH | 2 |
| Chen, FL | 2 |
| Tian, S | 1 |
| Paudel, D | 1 |
| Hao, F | 1 |
| Neupane, R | 1 |
| Castro, R | 1 |
| Patterson, AD | 1 |
| Tiwari, AK | 1 |
| Prabhu, KS | 1 |
| Singh, V | 1 |
| Spiga, L | 1 |
| Winter, MG | 1 |
| Furtado de Carvalho, T | 1 |
| Zhu, W | 1 |
| Hughes, ER | 1 |
| Gillis, CC | 1 |
| Behrendt, CL | 1 |
| Kim, J | 1 |
| Chessa, D | 1 |
| Andrews-Polymenis, HL | 1 |
| Beiting, DP | 1 |
| Santos, RL | 1 |
| Hooper, LV | 1 |
| Winter, SE | 1 |
| Macias-Ceja, DC | 1 |
| Ortiz-Masiá, D | 1 |
| Salvador, P | 1 |
| Gisbert-Ferrándiz, L | 1 |
| Hernández, C | 1 |
| Hausmann, M | 1 |
| Rogler, G | 1 |
| Esplugues, JV | 1 |
| Hinojosa, J | 1 |
| Alós, R | 1 |
| Navarro, F | 1 |
| Cosin-Roger, J | 1 |
| Calatayud, S | 1 |
| Barrachina, MD | 1 |
| Martin, FP | 1 |
| Lichti, P | 1 |
| Bosco, N | 1 |
| Brahmbhatt, V | 1 |
| Oliveira, M | 1 |
| Haller, D | 1 |
| Benyacoub, J | 1 |
| Varshosaz, J | 1 |
| Emami, J | 1 |
| Fassihi, A | 1 |
| Tavakoli, N | 1 |
| Minaiyan, M | 1 |
| Ahmadi, F | 1 |
| Mahzouni, P | 1 |
| Dorkoosh, F | 1 |
| Komiyama, Y | 1 |
| Mitsuyama, K | 1 |
| Masuda, J | 1 |
| Yamasaki, H | 1 |
| Takedatsu, H | 1 |
| Andoh, A | 1 |
| Tsuruta, O | 1 |
| Fukuda, M | 1 |
| Kanauchi, O | 1 |
| Ariake, K | 1 |
| Ohkusa, T | 1 |
| Sakurazawa, T | 1 |
| Kumagai, J | 1 |
| Eishi, Y | 1 |
| Hoshi, S | 1 |
| Yajima, T | 1 |
| Osman, N | 1 |
| Adawi, D | 1 |
| Molin, G | 1 |
| Ahrne, S | 1 |
| Berggren, A | 1 |
| Jeppsson, B | 1 |
| Fukui, S | 1 |
| Shimoyama, T | 1 |
| Tamura, K | 1 |
| Yamamura, M | 1 |
| Satomi, M | 1 |
11 other studies available for succinic acid and Colitis
| Article | Year |
|---|---|
Mitochondrial complex II in intestinal epithelial cells regulates T cell-mediated immunopathology.
Topics: Animals; Case-Control Studies; Cell Communication; Cells, Cultured; Colitis; Colon; Cytotoxicity, Im | 2021 |
Xianglian pill modulates gut microbial production of succinate and induces regulatory T cells to alleviate ulcerative colitis in rats.
Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointesti | 2023 |
Xianglian pill modulates gut microbial production of succinate and induces regulatory T cells to alleviate ulcerative colitis in rats.
Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointesti | 2023 |
Xianglian pill modulates gut microbial production of succinate and induces regulatory T cells to alleviate ulcerative colitis in rats.
Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointesti | 2023 |
Xianglian pill modulates gut microbial production of succinate and induces regulatory T cells to alleviate ulcerative colitis in rats.
Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointesti | 2023 |
Refined fiber inulin promotes inflammation-associated colon tumorigenesis by modulating microbial succinate production.
Topics: Animals; Carcinogenesis; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Colorectal Neo | 2023 |
An Oxidative Central Metabolism Enables Salmonella to Utilize Microbiota-Derived Succinate.
Topics: Animals; Bacteria; Bacteroides; Citric Acid Cycle; Colitis; Gastrointestinal Microbiome; Humans; Int | 2017 |
Succinate receptor mediates intestinal inflammation and fibrosis.
Topics: Adolescent; Adult; Animals; Cells, Cultured; Colitis; Crohn Disease; Disease Models, Animal; Female; | 2019 |
Metabolic phenotyping of an adoptive transfer mouse model of experimental colitis and impact of dietary fish oil intake.
Topics: Adoptive Transfer; Animals; Colitis; Dietary Supplements; Feces; Fish Oils; Glutamine; Ketoglutaric | 2015 |
Effectiveness of budesonide-succinate-dextran conjugate as a novel prodrug of budesonide against acetic acid-induced colitis in rats.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Budesonide; Colitis; Dextrans; Hydrocortisone; Male; | 2010 |
Prebiotic treatment in experimental colitis reduces the risk of colitic cancer.
Topics: Adenoma; Animals; beta-Glucosidase; Cell Proliferation; Colitis; Colon; Colonic Neoplasms; Colonosco | 2011 |
Roles of mucosal bacteria and succinic acid in colitis caused by dextran sulfate sodium in mice.
Topics: Acetates; Animals; Bacteroidaceae; Bacteroides; Butyric Acid; Carboxylic Acids; Cecum; Colitis; Coli | 2000 |
Bifidobacterium infantis strains with and without a combination of oligofructose and inulin (OFI) attenuate inflammation in DSS-induced colitis in rats.
Topics: Animals; Bacterial Translocation; Bifidobacterium; Cecum; Colitis; Colon; Colony Count, Microbial; C | 2006 |
Mucosal blood flow and generation of superoxide in rat experimental colitis induced by succinic acid.
Topics: Animals; Colitis; Colon; Dose-Response Relationship, Drug; Intestinal Mucosa; Luminescent Measuremen | 1997 |