succinic acid has been researched along with Cell Transformation, Neoplastic in 10 studies
Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There is an increased risk of colon cancer associated with inflammatory bowel disease (IBD)." | 1.91 | Refined fiber inulin promotes inflammation-associated colon tumorigenesis by modulating microbial succinate production. ( Castro, R; Hao, F; Neupane, R; Patterson, AD; Paudel, D; Prabhu, KS; Singh, V; Tian, S; Tiwari, AK, 2023) |
| "Oral squamous cell carcinoma (OSCC) is usually diagnosed at late stages, which leads to high morbidity." | 1.56 | Metabolic changes during malignant transformation in primary cells of oral lichen planus: Succinate accumulation and tumour suppression. ( Guo, B; Hexige, S; Sun, H; Wang, X; Yang, Q; Yu, X; Zhang, J, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 6 (60.00) | 2.80 |
| Authors | Studies |
|---|---|
| Armstrong, N | 1 |
| Storey, CM | 1 |
| Noll, SE | 1 |
| Margulis, K | 1 |
| Soe, MH | 1 |
| Xu, H | 1 |
| Yeh, B | 1 |
| Fishbein, L | 1 |
| Kebebew, E | 1 |
| Howitt, BE | 1 |
| Zare, RN | 1 |
| Sage, J | 1 |
| Annes, JP | 1 |
| Bancel, LP | 1 |
| Masso, V | 1 |
| Dessein, AF | 1 |
| Aubert, S | 1 |
| Leteurtre, E | 1 |
| Coppin, L | 1 |
| Odou, MF | 1 |
| Cao, CD | 1 |
| Cardot-Bauters, C | 1 |
| Pigny, P | 1 |
| Yu, Z | 1 |
| Peng, Y | 1 |
| Gao, J | 1 |
| Zhou, M | 1 |
| Shi, L | 1 |
| Zhao, F | 1 |
| Wang, C | 1 |
| Tian, X | 1 |
| Feng, L | 1 |
| Huo, X | 1 |
| Zhang, B | 1 |
| Liu, M | 1 |
| Fang, D | 1 |
| Ma, X | 1 |
| Tian, S | 1 |
| Paudel, D | 1 |
| Hao, F | 1 |
| Neupane, R | 1 |
| Castro, R | 1 |
| Patterson, AD | 1 |
| Tiwari, AK | 1 |
| Prabhu, KS | 1 |
| Singh, V | 1 |
| Yang, Q | 1 |
| Sun, H | 1 |
| Wang, X | 1 |
| Yu, X | 1 |
| Zhang, J | 1 |
| Guo, B | 1 |
| Hexige, S | 1 |
| Li, ST | 1 |
| Shen, S | 1 |
| Cai, Y | 1 |
| Xing, S | 1 |
| Wu, G | 1 |
| Jiang, Z | 1 |
| Hao, Y | 1 |
| Yuan, M | 1 |
| Wang, N | 1 |
| Zhu, L | 1 |
| Yan, R | 1 |
| Yang, D | 1 |
| Wang, L | 1 |
| Liu, Z | 1 |
| Hu, X | 1 |
| Zhou, R | 1 |
| Qu, K | 1 |
| Li, A | 1 |
| Duan, X | 1 |
| Zhang, H | 1 |
| Gao, P | 1 |
| Porcelli, AM | 2 |
| Ghelli, A | 2 |
| Ceccarelli, C | 2 |
| Lang, M | 1 |
| Cenacchi, G | 1 |
| Capristo, M | 2 |
| Pennisi, LF | 1 |
| Morra, I | 1 |
| Ciccarelli, E | 1 |
| Melcarne, A | 1 |
| Bartoletti-Stella, A | 1 |
| Salfi, N | 1 |
| Tallini, G | 1 |
| Martinuzzi, A | 1 |
| Carelli, V | 2 |
| Attimonelli, M | 1 |
| Rugolo, M | 2 |
| Romeo, G | 2 |
| Gasparre, G | 2 |
| Wittwer, JA | 1 |
| Robbins, D | 1 |
| Wang, F | 1 |
| Codarin, S | 1 |
| Shen, X | 1 |
| Kevil, CG | 1 |
| Huang, TT | 1 |
| Van Remmen, H | 1 |
| Richardson, A | 1 |
| Zhao, Y | 1 |
| Kurelac, I | 1 |
| Iommarini, L | 1 |
| Nicoletti, G | 1 |
| Nanni, P | 1 |
| De Giovanni, C | 1 |
| Scotlandi, K | 1 |
| Betts, CM | 1 |
| Lollini, PL | 1 |
| Selak, MA | 1 |
| Armour, SM | 1 |
| MacKenzie, ED | 1 |
| Boulahbel, H | 1 |
| Watson, DG | 1 |
| Mansfield, KD | 1 |
| Pan, Y | 1 |
| Simon, MC | 1 |
| Thompson, CB | 1 |
| Gottlieb, E | 1 |
10 other studies available for succinic acid and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
SDHB knockout and succinate accumulation are insufficient for tumorigenesis but dual SDHB/NF1 loss yields SDHx-like pheochromocytomas.
Topics: Adrenal Gland Neoplasms; Animals; Carcinogenesis; Cell Transformation, Neoplastic; Dioxygenases; Mic | 2022 |
Serum Succinate/Fumarate Ratio in Patients With Paraganglioma/Pheochromocytoma Attending an Endocrine Oncogenetic Unit.
Topics: Adrenal Gland Neoplasms; Carcinogenesis; Cell Transformation, Neoplastic; Fumarates; Germ-Line Mutat | 2023 |
The p23 co-chaperone is a succinate-activated COX-2 transcription factor in lung adenocarcinoma tumorigenesis.
Topics: Adenocarcinoma of Lung; Carcinogenesis; Cell Transformation, Neoplastic; Cyclooxygenase 2; HSP90 Hea | 2023 |
Refined fiber inulin promotes inflammation-associated colon tumorigenesis by modulating microbial succinate production.
Topics: Animals; Carcinogenesis; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Colorectal Neo | 2023 |
Metabolic changes during malignant transformation in primary cells of oral lichen planus: Succinate accumulation and tumour suppression.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Squamous Cell; Case-Control Studies; C | 2020 |
Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis.
Topics: Acetylation; Cell Transformation, Neoplastic; Citric Acid Cycle; Electron Transport Complex II; Epig | 2020 |
The genetic and metabolic signature of oncocytic transformation implicates HIF1alpha destabilization.
Topics: Cell Hypoxia; Cell Respiration; Cell Transformation, Neoplastic; DNA, Mitochondrial; Electron Transp | 2010 |
Enhancing mitochondrial respiration suppresses tumor promoter TPA-induced PKM2 expression and cell transformation in skin epidermal JB6 cells.
Topics: Animals; Cell Respiration; Cell Transformation, Neoplastic; Humans; Malates; Mice; Mice, Inbred C57B | 2011 |
A mutation threshold distinguishes the antitumorigenic effects of the mitochondrial gene MTND1, an oncojanus function.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Transformation, Neoplastic; Electron Transport Complex I; | 2011 |
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Citric Acid Cycle; Enzyme Activation; Gene Expr | 2005 |