succinic acid has been researched along with Cancer of Kidney in 10 studies
Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Succinic acid is a focal point for cancer treatments not only for its apoptotic success on cancer cells but also for its capacity to be metabolically active for humans." | 1.62 | The apoptotic efficacy of succinic acid on renal cancer cell lines. ( Cakmakoglu, B; Ertugrul, B; Iplik, ES; Kasarci, G, 2021) |
| "In light of the increasing incidence of renal cell carcinoma (RCC), its molecular mechanisms have been comprehensively explored in numerous recent studies." | 1.48 | Quantitative Global Proteome and Lysine Succinylome Analyses Reveal the Effects of Energy Metabolism in Renal Cell Carcinoma. ( Bi, J; Gao, R; Gong, D; Kong, C; Li, J; Li, Z; Liu, X; Wang, J; Xu, X; Yang, J; Zhang, N; Zhang, Z; Zhu, Y, 2018) |
| "Phenformin treatment inhibited the development of induced tumors in the nervous system and kidneys, significantly decreased the total incidence and multiplicity of these tumors, the incidence of brain and spinal cord tumors and multiplicity of brain tumors." | 1.27 | [Effect of phenformin and succinic acid on the transplacental carcinogenic effect of N-nitroso-N-ethylurea in rats]. ( Aleksandrov, VA; Bespalov, VG, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 3 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kasarci, G | 1 |
| Ertugrul, B | 1 |
| Iplik, ES | 1 |
| Cakmakoglu, B | 1 |
| Zheng, L | 1 |
| Zhu, ZR | 1 |
| Sneh, T | 1 |
| Zhang, WT | 1 |
| Wang, ZY | 1 |
| Wu, GY | 1 |
| He, W | 1 |
| Qi, HG | 1 |
| Wang, H | 1 |
| Wu, XY | 1 |
| Fernández-García, J | 1 |
| Abramovich, I | 1 |
| Xu, YZ | 1 |
| Zhang, J | 1 |
| Gottlieb, E | 1 |
| Zhang, N | 1 |
| Gao, R | 1 |
| Yang, J | 1 |
| Zhu, Y | 1 |
| Zhang, Z | 1 |
| Xu, X | 1 |
| Wang, J | 1 |
| Liu, X | 1 |
| Li, Z | 2 |
| Gong, D | 1 |
| Li, J | 1 |
| Bi, J | 1 |
| Kong, C | 1 |
| Ma, Y | 1 |
| Qi, Y | 1 |
| Wang, L | 1 |
| Zheng, Z | 1 |
| Zhang, Y | 1 |
| Zheng, J | 1 |
| Eijkelenkamp, K | 1 |
| Osinga, TE | 1 |
| Links, TP | 1 |
| van der Horst-Schrivers, ANA | 1 |
| Ternette, N | 2 |
| Yang, M | 1 |
| Laroyia, M | 1 |
| Kitagawa, M | 1 |
| O'Flaherty, L | 2 |
| Wolhulter, K | 1 |
| Igarashi, K | 1 |
| Saito, K | 1 |
| Kato, K | 1 |
| Fischer, R | 1 |
| Berquand, A | 1 |
| Kessler, BM | 1 |
| Lappin, T | 1 |
| Frizzell, N | 2 |
| Soga, T | 1 |
| Adam, J | 2 |
| Pollard, PJ | 2 |
| Kerins, MJ | 1 |
| Vashisht, AA | 1 |
| Liang, BX | 1 |
| Duckworth, SJ | 1 |
| Praslicka, BJ | 1 |
| Wohlschlegel, JA | 1 |
| Ooi, A | 1 |
| Bardella, C | 1 |
| El-Bahrawy, M | 1 |
| Hatipoglu, E | 1 |
| Howarth, K | 1 |
| Roberts, I | 1 |
| Turner, G | 1 |
| Taylor, J | 1 |
| Giaslakiotis, K | 1 |
| Macaulay, VM | 1 |
| Harris, AL | 1 |
| Chandra, A | 1 |
| Lehtonen, HJ | 1 |
| Launonen, V | 1 |
| Aaltonen, LA | 1 |
| Pugh, CW | 1 |
| Mihai, R | 1 |
| Trudgian, D | 1 |
| Kessler, B | 1 |
| Baynes, JW | 1 |
| Ratcliffe, PJ | 1 |
| Tomlinson, IP | 1 |
| Bespalov, VG | 1 |
| Aleksandrov, VA | 1 |
| Jung, K | 1 |
| Reinholdt, C | 1 |
1 review available for succinic acid and Cancer of Kidney
| Article | Year |
|---|---|
Clinical implications of the oncometabolite succinate in SDHx-mutation carriers.
Topics: Adrenal Gland Neoplasms; Biomarkers, Tumor; Carcinoma, Renal Cell; Genetic Predisposition to Disease | 2020 |
9 other studies available for succinic acid and Cancer of Kidney
| Article | Year |
|---|---|
The apoptotic efficacy of succinic acid on renal cancer cell lines.
Topics: alpha-Tocopherol; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; | 2021 |
Circulating succinate-modifying metabolites accurately classify and reflect the status of fumarate hydratase-deficient renal cell carcinoma.
Topics: Carcinoma, Renal Cell; Fumarate Hydratase; Humans; Kidney Neoplasms; Mutation; Succinic Acid; Tumor | 2023 |
Quantitative Global Proteome and Lysine Succinylome Analyses Reveal the Effects of Energy Metabolism in Renal Cell Carcinoma.
Topics: Biomarkers, Tumor; Carcinoma, Renal Cell; Energy Metabolism; Humans; Kidney; Kidney Neoplasms; Lysin | 2018 |
SIRT5-mediated SDHA desuccinylation promotes clear cell renal cell carcinoma tumorigenesis.
Topics: Carcinoma, Renal Cell; Cell Proliferation; Electron Transport Complex II; Humans; Kidney Neoplasms; | 2019 |
Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency.
Topics: Aconitate Hydratase; Animals; Cell Line; Cysteine; Fumarate Hydratase; Fumarates; Humans; Iron; Kidn | 2013 |
Fumarate Mediates a Chronic Proliferative Signal in Fumarate Hydratase-Inactivated Cancer Cells by Increasing Transcription and Translation of Ferritin Genes.
Topics: Amino Acid Sequence; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Ferritins; Forkhea | 2017 |
Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status.
Topics: Adult; Aged; Animals; Biomarkers, Tumor; Carcinoma, Renal Cell; Disease Models, Animal; Female; Fuma | 2011 |
[Effect of phenformin and succinic acid on the transplacental carcinogenic effect of N-nitroso-N-ethylurea in rats].
Topics: Animals; Ethylnitrosourea; Female; Kidney Neoplasms; Maternal-Fetal Exchange; Neoplasms, Experimenta | 1984 |
[Oxidative and respiratory properties of isolated human kidney mitochondria].
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Culture Techniques; Energy Metabolism; Glutamates; Gl | 1987 |