succinic acid has been researched along with Brain Ischemia in 12 studies
Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Propofol (2,6-diisopropylphenol) has been proven to attenuate mitochondrial dysfunction and reperfusion injury." | 7.88 | Propofol Prevents Oxidative Stress by Decreasing the Ischemic Accumulation of Succinate in Focal Cerebral Ischemia-Reperfusion Injury. ( Gao, D; Jin, W; Liu, S; Qi, S; Yu, W, 2018) |
| " Propofol (2,6-diisopropylphenol) has been proven to attenuate mitochondrial dysfunction and reperfusion injury." | 3.88 | Propofol Prevents Oxidative Stress by Decreasing the Ischemic Accumulation of Succinate in Focal Cerebral Ischemia-Reperfusion Injury. ( Gao, D; Jin, W; Liu, S; Qi, S; Yu, W, 2018) |
| "Current treatments for acute ischemic stroke aim to reinstate a normal perfusion in the ischemic territory but can also cause significant ischemia-reperfusion (IR) injury." | 1.91 | Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke. ( Burger, N; Dannhorn, A; Frezza, C; Goodwin, R; Huang, MM; Krieg, T; Kulaveerasingam, D; Lee, JJ; Mair, R; Mottahedin, A; Murphy, MP; Peruzzotti-Jametti, L; Pluchino, S; Prag, HA; Schmidt, C; Sorby-Adams, A; Yang, M, 2023) |
| "Stroke was induced in mice by middle cerebral artery occlusion for 90 minutes, followed by reperfusion." | 1.46 | Hepatic Ketogenesis Induced by Middle Cerebral Artery Occlusion in Mice. ( Berressem, D; Eckert, GP; Klein, J; Koch, K; Konietzka, J; Thinnes, A, 2017) |
| "Neuroprotective properties of ketosis may be related to the upregulation of hypoxia inducible factor (HIF)-1alpha, a primary constituent associated with hypoxic angiogenesis and a regulator of neuroprotective responses." | 1.35 | Neuroprotection in diet-induced ketotic rat brain after focal ischemia. ( Emancipator, DS; LaManna, JC; Lust, WD; Puchowicz, MA; Pundik, S; Valerio, J; Xu, K; Zechel, JL, 2008) |
| "The succinic acid prevented the increase of cholesterol, triglyceride and low density lipoproteins in the blood." | 1.30 | Prophylaxis of encephalopathies and risk factors of atherogenesis development in the postresuscitation period in rats by means of succinic acid. ( Avruschenko, MS; Gulyaeva, NV; Gurvitch, AM; Lazareva, NA; Mutuskina, EA; Onufriev, MV; Pylova, SI; Stepanichev, MY; Trubina, IE; Volkov, AV; Zarzhetsky, YV, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Mottahedin, A | 1 |
| Prag, HA | 1 |
| Dannhorn, A | 1 |
| Mair, R | 1 |
| Schmidt, C | 1 |
| Yang, M | 1 |
| Sorby-Adams, A | 1 |
| Lee, JJ | 1 |
| Burger, N | 1 |
| Kulaveerasingam, D | 1 |
| Huang, MM | 1 |
| Pluchino, S | 1 |
| Peruzzotti-Jametti, L | 1 |
| Goodwin, R | 1 |
| Frezza, C | 1 |
| Murphy, MP | 1 |
| Krieg, T | 1 |
| Nguépy Keubo, FR | 1 |
| Mboua, PC | 1 |
| Djifack Tadongfack, T | 1 |
| Fokouong Tchoffo, E | 1 |
| Tasson Tatang, C | 1 |
| Ide Zeuna, J | 1 |
| Noupoue, EM | 1 |
| Tsoplifack, CB | 1 |
| Folefack, GO | 1 |
| Kettani, M | 1 |
| Bandelier, P | 1 |
| Huo, J | 1 |
| Li, H | 4 |
| Yu, D | 1 |
| Arulsamy, N | 1 |
| AlAbbad, S | 1 |
| Sardot, T | 1 |
| Lekashvili, O | 1 |
| Decato, D | 1 |
| Lelj, F | 1 |
| Alexander Ross, JB | 1 |
| Rosenberg, E | 1 |
| Nazir, H | 1 |
| Muthuswamy, N | 1 |
| Louis, C | 1 |
| Jose, S | 1 |
| Prakash, J | 1 |
| Buan, MEM | 1 |
| Flox, C | 1 |
| Chavan, S | 1 |
| Shi, X | 1 |
| Kauranen, P | 1 |
| Kallio, T | 1 |
| Maia, G | 1 |
| Tammeveski, K | 1 |
| Lymperopoulos, N | 1 |
| Carcadea, E | 1 |
| Veziroglu, E | 1 |
| Iranzo, A | 1 |
| M Kannan, A | 1 |
| Arunamata, A | 1 |
| Tacy, TA | 1 |
| Kache, S | 1 |
| Mainwaring, RD | 1 |
| Ma, M | 1 |
| Maeda, K | 1 |
| Punn, R | 1 |
| Noguchi, S | 1 |
| Hahn, S | 3 |
| Iwasa, Y | 3 |
| Ling, J | 2 |
| Voccio, JP | 2 |
| Kim, Y | 3 |
| Song, J | 3 |
| Bascuñán, J | 2 |
| Chu, Y | 1 |
| Tomita, M | 1 |
| Cazorla, M | 1 |
| Herrera, E | 1 |
| Palomeque, E | 1 |
| Saud, N | 1 |
| Hoplock, LB | 1 |
| Lobchuk, MM | 1 |
| Lemoine, J | 1 |
| Li, X | 10 |
| Henson, MA | 1 |
| Unsihuay, D | 1 |
| Qiu, J | 1 |
| Swaroop, S | 1 |
| Nagornov, KO | 1 |
| Kozhinov, AN | 1 |
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| Laskin, J | 1 |
| Zin, NNINM | 1 |
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| Abdul Wafi, S | 1 |
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| Fan, XH | 1 |
| Chen, KP | 1 |
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| Liu, ZM | 1 |
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| Zhou, B | 1 |
| Zhang, S | 2 |
| Xing, YL | 1 |
| Chen, MA | 1 |
| Sun, Y | 1 |
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| Wu, XT | 1 |
| Zhang, D | 2 |
| Huang, W | 1 |
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| Yang, QQ | 1 |
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| Zhao, XQ | 1 |
| Hossein Rashidi, B | 1 |
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| Li, J | 7 |
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| Hou, J | 1 |
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| Zhu, J | 2 |
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| Zhuang, T | 1 |
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| Yao, H | 1 |
| Wang, X | 5 |
| Lee, DF | 1 |
| Shen, J | 3 |
| Wen, L | 1 |
| Huang, G | 2 |
| Xie, X | 1 |
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| Zhang, Y | 4 |
| Wu, X | 1 |
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| Xu, Z | 1 |
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| Huang, H | 1 |
| Wei, Y | 2 |
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| Na, KJ | 1 |
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| Chung, DH | 1 |
| Paeng, JC | 1 |
| Park, IK | 1 |
| Kang, CH | 1 |
| Cheon, GJ | 1 |
| Kang, KW | 1 |
| Lee, DS | 1 |
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| Pajuelo-Lozano, N | 1 |
| Alcalá, S | 1 |
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| Logotheti, S | 1 |
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| Rathore, MG | 1 |
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| Cai, X | 1 |
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| Shi, Y | 1 |
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| Patsourakos, NG | 1 |
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| Kotidis, A | 1 |
| Kalantzi, KI | 1 |
| Tsoumani, ME | 1 |
| Anastasiadis, F | 1 |
| Andronikos, P | 1 |
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| Efraimidis, P | 1 |
| Georgiopoulos, A | 1 |
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| Grigoriadou-Skouta, E | 1 |
| Grigoropoulos, P | 1 |
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| Kartalis, A | 1 |
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| Markatos, G | 1 |
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| Culquichicón, C | 1 |
| Solis Condor, R | 1 |
| Efendi, F | 1 |
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| Hadisuyatmana, S | 1 |
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| Kuswanto, H | 1 |
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| Ahmadi, F | 1 |
| Moayer, F | 1 |
| Khalvati, S | 1 |
| Zhang, Q | 2 |
| Lyu, Y | 1 |
| Huang, J | 1 |
| Yu, N | 1 |
| Wen, Z | 1 |
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| Zhao, T | 1 |
| Gupta, A | 1 |
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| Govindasamy, V | 1 |
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1 review available for succinic acid and Brain Ischemia
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
1 trial available for succinic acid and Brain Ischemia
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
11 other studies available for succinic acid and Brain Ischemia
| Article | Year |
|---|---|
Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke.
Topics: Animals; Brain Injuries; Brain Ischemia; Humans; Ischemia; Ischemic Stroke; Mice; Reperfusion Injury | 2023 |
Hepatic Ketogenesis Induced by Middle Cerebral Artery Occlusion in Mice.
Topics: 3-Hydroxybutyric Acid; Adrenergic beta-Antagonists; Animals; Brain; Brain Ischemia; Citric Acid; Die | 2017 |
Succinate-induced neuronal mitochondrial fission and hexokinase II malfunction in ischemic stroke: Therapeutical effects of kaempferol.
Topics: Animals; Autophagy; Brain Ischemia; Dynamins; Gene Knockdown Techniques; Hexokinase; Kaempferols; Ma | 2017 |
Propofol Prevents Oxidative Stress by Decreasing the Ischemic Accumulation of Succinate in Focal Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Brain Ischemia; Ischemia; Male; Membrane Potential, Mitochondrial; Mitochondria; Neuroprote | 2018 |
Neuroprotection in diet-induced ketotic rat brain after focal ischemia.
Topics: Animals; Brain; Brain Edema; Brain Infarction; Brain Ischemia; Diet, Ketogenic; Disease Models, Anim | 2008 |
Effects of cytoflavin and neuronol on morphological changes in the brain and survival of rats with ischemic disturbances in cerebral blood flow.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Drug Combinations; Flavin Mononucleotid | 2004 |
[Use of sodium succinate in complex treatment of ischemic stroke].
Topics: Adult; Aged; Antioxidants; Brain Ischemia; Female; Humans; Male; Middle Aged; Succinic Acid | 2004 |
Effects of naftidrofuryl oxalate on microsphere embolism-induced changes in tricarboxylic acid cycle intermediates of rats.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Citrates; Citric Acid; Citric Acid Cycle; Fumarates; Intra | 1993 |
[Ammonium succinate--an effective corrector of cerebral circulatory hypoxia].
Topics: Animals; Brain Ischemia; Hypoxia, Brain; Lipid Peroxidation; Male; Malondialdehyde; Rats; Rats, Wist | 1994 |
Prophylaxis of encephalopathies and risk factors of atherogenesis development in the postresuscitation period in rats by means of succinic acid.
Topics: Animals; Arteriosclerosis; Behavior, Animal; Brain Ischemia; Cardiopulmonary Resuscitation; Disease | 1997 |
Cerebral resuscitation with succinate and fructose-1, 6-diphosphate.
Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Electroencephalography; Fructosediphosphates; | 1989 |