succinic acid has been researched along with Autosomal Dominant Cerebellar Ataxia, Type II in 2 studies
Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acute treatment of postsymptomatic SCA1 mice with succinic acid, a complex II (succinate dehydrogenase) electron donor to bypass complex I dysfunction, ameliorated cerebellar OXPHOS dysfunction, reduced cerebellar pathology and improved motor behavior." | 1.46 | Short-term succinic acid treatment mitigates cerebellar mitochondrial OXPHOS dysfunction, neurodegeneration and ataxia in a Purkinje-specific spinocerebellar ataxia type 1 (SCA1) mouse model. ( Berry, G; Carbone, E; Ferro, A; Frederick, K; Hartman, J; Ingram, MA; Ives, S; Lagalwar, S; Marzouk, E; Nguyen, D; Polley, K; Possidente, B; Possidente, T; Reynolds, TH; Siegel, A; Villegas, M; Zhang, J, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ferro, A | 2 |
| Carbone, E | 2 |
| Zhang, J | 1 |
| Marzouk, E | 2 |
| Villegas, M | 1 |
| Siegel, A | 2 |
| Nguyen, D | 2 |
| Possidente, T | 1 |
| Hartman, J | 2 |
| Polley, K | 2 |
| Ingram, MA | 1 |
| Berry, G | 1 |
| Reynolds, TH | 1 |
| Possidente, B | 1 |
| Frederick, K | 2 |
| Ives, S | 2 |
| Lagalwar, S | 2 |
2 other studies available for succinic acid and Autosomal Dominant Cerebellar Ataxia, Type II
| Article | Year |
|---|---|
Short-term succinic acid treatment mitigates cerebellar mitochondrial OXPHOS dysfunction, neurodegeneration and ataxia in a Purkinje-specific spinocerebellar ataxia type 1 (SCA1) mouse model.
Topics: Animals; Cerebellum; Disease Models, Animal; Mice; Mice, Transgenic; Mitochondria; Oxidative Phospho | 2017 |
Treating SCA1 Mice with Water-Soluble Compounds to Non-Specifically Boost Mitochondrial Function.
Topics: Animals; Behavior, Animal; Cerebellum; Chromatography, High Pressure Liquid; Dendrites; Disease Mode | 2017 |