succinic acid has been researched along with Aging in 31 studies
Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In rats with beta-amyloid peptide-(25-35)-induced amnesia, CS enhanced passive avoidance performance and increased activity of brain choline acetyltransferase, as compared to control rats (saline)." | 7.74 | Dicholine salt of succinic acid, a neuronal insulin sensitizer, ameliorates cognitive deficits in rodent models of normal aging, chronic cerebral hypoperfusion, and beta-amyloid peptide-(25-35)-induced amnesia. ( Persiyantseva, NA; Pinelis, VG; Pomytkin, IA; Proshin, AT; Semenova, NA; Senilova, YE; Sherstnev, VV; Storozheva, ZI; Storozhevykh, TP; Zakharova, EI, 2008) |
| "The ratio of 5-hydroxymethylcytosine to 5-methylcytosine increases over aging in the SN, and 5-hydroxymethylcytosine increases preferentially in dopaminergic neurons." | 3.85 | Distinct cellular and molecular environments support aging-related DNA methylation changes in the substantia nigra. ( Fasolino, M; Liu, S; Wang, Y; Zhou, Z, 2017) |
| " In rats with beta-amyloid peptide-(25-35)-induced amnesia, CS enhanced passive avoidance performance and increased activity of brain choline acetyltransferase, as compared to control rats (saline)." | 3.74 | Dicholine salt of succinic acid, a neuronal insulin sensitizer, ameliorates cognitive deficits in rodent models of normal aging, chronic cerebral hypoperfusion, and beta-amyloid peptide-(25-35)-induced amnesia. ( Persiyantseva, NA; Pinelis, VG; Pomytkin, IA; Proshin, AT; Semenova, NA; Senilova, YE; Sherstnev, VV; Storozheva, ZI; Storozhevykh, TP; Zakharova, EI, 2008) |
| " This study examined whether chronic intake of polyphenols (PPs), which are known to be modulators of oxidative stress, might prevent the age-related decline of mitochondrial functions in skeletal muscle." | 1.39 | Polyphenols prevent ageing-related impairment in skeletal muscle mitochondrial function through decreased reactive oxygen species production. ( Auger, C; Charles, AL; Dal-Ros, S; Geny, B; Keller, N; Metzger, D; Meyer, A; Ramamoorthy, TG; Schini-Kerth, V; Zoll, J, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (12.90) | 18.7374 |
| 1990's | 7 (22.58) | 18.2507 |
| 2000's | 11 (35.48) | 29.6817 |
| 2010's | 8 (25.81) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, M | 1 |
| Qin, Y | 1 |
| Li, A | 1 |
| Wei, S | 1 |
| Liu, B | 1 |
| Tian, X | 1 |
| Gong, G | 1 |
| Marden, JH | 1 |
| Fescemyer, HW | 1 |
| Schilder, RJ | 1 |
| Doerfler, WR | 1 |
| Vera, JC | 1 |
| Wheat, CW | 1 |
| Salminen, A | 1 |
| Kaarniranta, K | 1 |
| Hiltunen, M | 1 |
| Kauppinen, A | 1 |
| Donato, AJ | 1 |
| Henson, GD | 1 |
| Hart, CR | 1 |
| Layec, G | 1 |
| Trinity, JD | 1 |
| Bramwell, RC | 1 |
| Enz, RA | 1 |
| Morgan, RG | 1 |
| Reihl, KD | 1 |
| Hazra, S | 1 |
| Walker, AE | 1 |
| Richardson, RS | 1 |
| Lesniewski, LA | 1 |
| Bazhanova, ED | 1 |
| Anisimov, VN | 2 |
| Sukhanov, DS | 1 |
| Teplyĭ, DL | 1 |
| Fei, F | 1 |
| Lee, KM | 1 |
| McCarry, BE | 1 |
| Bowdish, DM | 1 |
| Fasolino, M | 1 |
| Liu, S | 1 |
| Wang, Y | 1 |
| Zhou, Z | 1 |
| Maevsky, EI | 1 |
| Peskov, AB | 1 |
| Uchitel, ML | 1 |
| Pogorelov, AG | 1 |
| Saharova, NY | 1 |
| Vihlyantseva, EF | 1 |
| Bogdanova, LA | 1 |
| Kondrashova, MN | 2 |
| Brown, JC | 1 |
| McClelland, GB | 1 |
| Faure, PA | 1 |
| Klaiman, JM | 1 |
| Staples, JF | 1 |
| Sumbalová, Z | 1 |
| Kucharská, J | 1 |
| Kristek, F | 1 |
| Ljubicic, V | 1 |
| Joseph, AM | 1 |
| Adhihetty, PJ | 1 |
| Huang, JH | 1 |
| Saleem, A | 1 |
| Uguccioni, G | 1 |
| Hood, DA | 1 |
| Charles, AL | 1 |
| Meyer, A | 1 |
| Dal-Ros, S | 1 |
| Auger, C | 1 |
| Keller, N | 1 |
| Ramamoorthy, TG | 1 |
| Zoll, J | 1 |
| Metzger, D | 1 |
| Schini-Kerth, V | 1 |
| Geny, B | 1 |
| St-Pierre, J | 1 |
| Buckingham, JA | 1 |
| Roebuck, SJ | 1 |
| Brand, MD | 1 |
| Popovich, IG | 1 |
| Zabezhinskii, MA | 1 |
| Kovalenko, AL | 1 |
| Petrov, AY | 1 |
| Semenchenko, AV | 1 |
| Yashin, AI | 1 |
| Knauf, F | 1 |
| Mohebbi, N | 1 |
| Teichert, C | 1 |
| Herold, D | 1 |
| Rogina, B | 1 |
| Helfand, S | 1 |
| Gollasch, M | 1 |
| Luft, FC | 1 |
| Aronson, PS | 1 |
| Sethumadhavan, S | 1 |
| Chinnakannu, P | 1 |
| Bollmann, FM | 1 |
| Storozheva, ZI | 1 |
| Proshin, AT | 1 |
| Sherstnev, VV | 1 |
| Storozhevykh, TP | 1 |
| Senilova, YE | 1 |
| Persiyantseva, NA | 1 |
| Pinelis, VG | 1 |
| Semenova, NA | 1 |
| Zakharova, EI | 1 |
| Pomytkin, IA | 1 |
| Baggetto, L | 1 |
| Gautheron, DC | 1 |
| Godinot, C | 1 |
| Horton, AA | 1 |
| Spencer, JA | 1 |
| Kaminskiĭ, IuG | 1 |
| Kosenko, EA | 1 |
| Boffoli, D | 1 |
| Scacco, SC | 1 |
| Vergari, R | 1 |
| Solarino, G | 1 |
| Santacroce, G | 1 |
| Papa, S | 1 |
| Gabbita, SP | 1 |
| Butterfield, DA | 1 |
| Hensley, K | 1 |
| Shaw, W | 1 |
| Carney, JM | 1 |
| Wolin, MJ | 1 |
| Yerry, S | 1 |
| Miller, TL | 1 |
| Zhang, Y | 1 |
| Bank, S | 1 |
| Goodell, S | 1 |
| Cortopassi, G | 1 |
| Marounek, M | 1 |
| Rada, V | 1 |
| Lossa, S | 1 |
| Lionetti, L | 1 |
| Mollica, MP | 1 |
| Crescenzo, R | 1 |
| Botta, M | 1 |
| Liverini, G | 1 |
| López-Torres, M | 1 |
| Gredilla, R | 1 |
| Sanz, A | 1 |
| Barja, G | 1 |
| Jani, MS | 1 |
| Telang, SD | 1 |
| Katyare, SS | 1 |
| Tummino, PJ | 1 |
| Gafni, A | 1 |
| Trounce, I | 1 |
| Byrne, E | 1 |
| Marzuki, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Citrulline Supplementation Combined With Exercise on Muscle Function and Functional Capacity in Older Obese Men and Women[NCT02417428] | 104 participants (Actual) | Interventional | 2015-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for succinic acid and Aging
| Article | Year |
|---|---|
Krebs cycle dysfunction shapes epigenetic landscape of chromatin: novel insights into mitochondrial regulation of aging process.
Topics: Aging; Chromatin; Citric Acid Cycle; Dioxygenases; DNA; DNA Methylation; DNA-Binding Proteins; Epige | 2014 |
1 trial available for succinic acid and Aging
| Article | Year |
|---|---|
A succinate-based composition reverses menopausal symptoms without sex hormone replacement therapy.
Topics: Adult; Aging; Animals; Autonomic Nervous System; Bone and Bones; Calcium; Dietary Supplements; Doubl | 2008 |
29 other studies available for succinic acid and Aging
| Article | Year |
|---|---|
Mitoflash generated at the Qo site of mitochondrial Complex III.
Topics: Adenosine Triphosphate; Aging; Animals; Antioxidants; Cell Membrane Permeability; Electron Transport | 2021 |
Genetic variation in HIF signaling underlies quantitative variation in physiological and life-history traits within lowland butterfly populations.
Topics: Aging; Alleles; Altitude; Animals; Butterflies; Ecosystem; Flight, Animal; Genes, Insect; Genetic Va | 2013 |
The impact of ageing on adipose structure, function and vasculature in the B6D2F1 mouse: evidence of significant multisystem dysfunction.
Topics: Adipose Tissue; Aging; Animals; Arteries; Body Weight; Carnitine; Glutamic Acid; Malates; Male; Mice | 2014 |
[Comparative experimental study of the influence of drugs that improve brain metabolism (angiogen, cytoflavin) on neuronal apoptosis and function of cerebral cortex during aging].
Topics: Aging; Animals; Apoptosis; Aspirin; Behavior, Animal; Caspase 3; Caspase 8; Cerebral Cortex; Cogniti | 2015 |
Age-associated metabolic dysregulation in bone marrow-derived macrophages stimulated with lipopolysaccharide.
Topics: Aging; Animals; Arginine; Cells, Cultured; gamma-Aminobutyric Acid; Glycolysis; Inflammation; Lipopo | 2016 |
Distinct cellular and molecular environments support aging-related DNA methylation changes in the substantia nigra.
Topics: 5-Methylcytosine; Aging; Animals; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Epigenesis, | 2017 |
Examining the mechanisms responsible for lower ROS release rates in liver mitochondria from the long-lived house sparrow (Passer domesticus) and big brown bat (Eptesicus fuscus) compared to the short-lived mouse (Mus musculus).
Topics: Aging; Animals; Chiroptera; Cytochromes c; Hydrogen Peroxide; Kinetics; Longevity; Membrane Potentia | 2009 |
Losartan improved respiratory function and coenzyme Q content in brain mitochondria of young spontaneously hypertensive rats.
Topics: Aging; alpha-Tocopherol; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Brain; Cell | 2010 |
Molecular basis for an attenuated mitochondrial adaptive plasticity in aged skeletal muscle.
Topics: Adaptation, Psychological; Aging; Animals; Apoptosis; DNA Fragmentation; Electric Stimulation; Elect | 2009 |
Polyphenols prevent ageing-related impairment in skeletal muscle mitochondrial function through decreased reactive oxygen species production.
Topics: Administration, Oral; Age Factors; Aging; Animals; Antioxidants; Ascorbic Acid; Electron Transport C | 2013 |
Topology of superoxide production from different sites in the mitochondrial electron transport chain.
Topics: Aging; Animals; Antimycin A; Columbidae; Electron Transport; Enzyme Inhibitors; Female; Hydrogen Per | 2002 |
Effect of neuronol on lifespan and development of spontaneous tumors in SAMP-1 mice with genetically accelerated aging.
Topics: Aging; Animals; Anticarcinogenic Agents; Drug Evaluation, Preclinical; Female; Histiocytoma, Benign | 2003 |
The life-extending gene Indy encodes an exchanger for Krebs-cycle intermediates.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Aging; Animals; Antiporters; Carbon Radioisotopes; | 2006 |
L-carnitine and alpha-lipoic acid improve age-associated decline in mitochondrial respiratory chain activity of rat heart muscle.
Topics: Aging; Analysis of Variance; Animals; Carnitine; Cell Respiration; Glutamic Acid; Hydroxybutyrates; | 2006 |
A model of metabolic changes in respiration-deficient human cells.
Topics: Aging; Cell Respiration; Cellular Senescence; DNA, Mitochondrial; Glycolysis; Humans; Models, Biolog | 2007 |
Dicholine salt of succinic acid, a neuronal insulin sensitizer, ameliorates cognitive deficits in rodent models of normal aging, chronic cerebral hypoperfusion, and beta-amyloid peptide-(25-35)-induced amnesia.
Topics: Aging; Amnesia; Amyloid beta-Peptides; Animals; Cerebrovascular Circulation; Choline; Cognition Diso | 2008 |
Effects of ATP on various steps controlling the rate of oxidative phosphorylation in newborn rat liver mitochondria.
Topics: Adenosine Triphosphate; Aging; Animals; Animals, Newborn; Biological Transport, Active; Electron Tra | 1984 |
Decline in respiratory control ratio of rat liver mitochondria in old age.
Topics: Adenosine Diphosphate; Aging; Animals; Energy Metabolism; Glutamates; Glutamic Acid; Malates; Mitoch | 1981 |
[Response of adenine nucleotide metabolism in the aged rat liver to fasting and succinate injections].
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Aging; Animals; Fasting; Liv | 1982 |
Decline with age of the respiratory chain activity in human skeletal muscle.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Ascorbic Acid; Cytochromes; Electron Transport Co | 1994 |
Aging and caloric restriction affect mitochondrial respiration and lipid membrane status: an electron paramagnetic resonance investigation.
Topics: Aging; Animals; Brain; Diet; Electron Spin Resonance Spectroscopy; Energy Intake; Free Radicals; Hum | 1997 |
Changes in production of ethanol, acids and H2 from glucose by the fecal flora of a 16- to 158-d-old breast-fed infant.
Topics: Acetates; Aging; Breast Feeding; Carboxylic Acids; Chromatography, High Pressure Liquid; Ethanol; Fe | 1998 |
Analysis of oxygen consumption and mitochondrial permeability with age in mice.
Topics: Aging; Animals; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Mitochondrial Swelling; Oxygen | 1998 |
Age effect on in vitro fermentation pattern and methane production in the caeca of chickens.
Topics: Aging; Ammonia; Animals; Cecum; Chickens; Ethanol; Fatty Acids; Female; Fermentation; Hydrogen; Lact | 1998 |
Mitochondrial respiration and triiodothyronine concentration in liver from postpubertal and adult rats.
Topics: Adenosine Triphosphate; Aging; Animals; Cell Respiration; Cytochrome c Group; Electron Transport Com | 2001 |
Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aging; Animals; Cell Nucleus; Deoxyguanosine; Diet, Reducing; DNA; DNA | 2002 |
Effect of corticosterone treatment on energy metabolism in rat liver mitochondria.
Topics: Adenosine Diphosphate; Aging; Animals; Ascorbic Acid; Corticosterone; Energy Metabolism; Glutamates; | 1991 |
A comparative study of succinate-supported respiration and ATP/ADP translocation in liver mitochondria from adult and old rats.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aging; Animals; Kinetics; Male; Mitochondria, Liver; | 1991 |
Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; DNA, Mitochondrial; Electron Transport Complex I | 1989 |