Page last updated: 2024-10-20

succinic acid and Adrenal Cancer

succinic acid has been researched along with Adrenal Cancer in 15 studies

Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.

Research Excerpts

ExcerptRelevanceReference
"Paraganglioma and pheochromocytoma are examples, whose etiology and therapy are complicated by the absence of representative cell lines or animal models."1.51Modeling succinate dehydrogenase loss disorders in C. elegans through effects on hypoxia-inducible factor. ( Braun, MM; Chen, C; Damjanac, T; Hu, J; Maher, LJ; Zhang, Y, 2019)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (40.00)24.3611
2020's9 (60.00)2.80

Authors

AuthorsStudies
Armstrong, N1
Storey, CM1
Noll, SE1
Margulis, K1
Soe, MH1
Xu, H1
Yeh, B1
Fishbein, L1
Kebebew, E1
Howitt, BE1
Zare, RN1
Sage, J1
Annes, JP1
Lamy, C1
Tissot, H1
Faron, M1
Baudin, E1
Lamartina, L1
Pradon, C1
Al Ghuzlan, A1
Leboulleux, S1
Perfettini, JL1
Paci, A1
Hadoux, J1
Broutin, S1
Gudgeon, N1
Munford, H1
Bishop, EL1
Hill, J1
Fulton-Ward, T1
Bending, D1
Roberts, J1
Tennant, DA1
Dimeloe, S1
Branzoli, F3
Salgues, B3
Marjańska, M3
Laloi-Michelin, M3
Herman, P3
Le Collen, L3
Delemer, B3
Riancho, J3
Kuhn, E3
Jublanc, C3
Burnichon, N4
Amar, L4
Favier, J4
Gimenez-Roqueplo, AP4
Buffet, A4
Lussey-Lepoutre, C4
Bancel, LP1
Masso, V1
Dessein, AF1
Aubert, S1
Leteurtre, E1
Coppin, L1
Odou, MF1
Cao, CD1
Cardot-Bauters, C1
Pigny, P1
Wang, Y2
Liu, B1
Li, F1
Zhang, Y2
Gao, X1
Zhou, H1
Bellucci, A1
Drossart, T1
Fontaine, S1
Clement, O1
Benit, P1
Rustin, P1
Groussin, L1
Meatchi, T1
Tavitian, B1
Braun, MM1
Damjanac, T1
Chen, C1
Hu, J1
Maher, LJ1
Hirose, R1
Tsurutani, Y1
Sugisawa, C1
Inoue, K1
Suematsu, S1
Nagata, M1
Hasegawa, N1
Kakuta, Y1
Yonamine, M1
Takekoshi, K1
Kimura, N1
Saito, J1
Nishikawa, T1
Taïeb, D1
Pacak, K4
Sulkowski, PL1
Sundaram, RK1
Oeck, S1
Corso, CD1
Liu, Y1
Noorbakhsh, S1
Niger, M1
Boeke, M1
Ueno, D1
Kalathil, AN1
Bao, X1
Li, J1
Shuch, B1
Bindra, RS1
Glazer, PM1
Eijkelenkamp, K1
Osinga, TE1
Links, TP1
van der Horst-Schrivers, ANA1
Rao, JU2
Engelke, UF1
Rodenburg, RJ1
Wevers, RA1
Eisenhofer, G3
Qin, N2
Kusters, B1
Goudswaard, AG1
Lenders, JW2
Hermus, AR1
Mensenkamp, AR1
Kunst, HP1
Sweep, FC1
Timmers, HJ2
Lendvai, N1
Pawlosky, R1
Bullova, P1
Patocs, A1
Veech, RL1
Richter, S1
Peitzsch, M1
Rapizzi, E1
de Cubas, AA1
Schiavi, F1
Beuschlein, F1
Quinkler, M1
Opocher, G1
Mannelli, M1
Robledo, M1

Reviews

3 reviews available for succinic acid and Adrenal Cancer

ArticleYear
The connection between tricarboxylic acid cycle enzyme mutations and pseudohypoxic signaling in pheochromocytoma and paraganglioma.
    Frontiers in endocrinology, 2023, Volume: 14

    Topics: Adrenal Gland Neoplasms; Citric Acid Cycle; Dioxygenases; Fumarates; Humans; Ketoglutaric Acids; Mut

2023
New Insights into the Nuclear Imaging Phenotypes of Cluster 1 Pheochromocytoma and Paraganglioma.
    Trends in endocrinology and metabolism: TEM, 2017, Volume: 28, Issue:11

    Topics: Adrenal Gland Neoplasms; Catecholamines; Fluorodeoxyglucose F18; Humans; Paraganglioma; Phenotype; P

2017
Clinical implications of the oncometabolite succinate in SDHx-mutation carriers.
    Clinical genetics, 2020, Volume: 97, Issue:1

    Topics: Adrenal Gland Neoplasms; Biomarkers, Tumor; Carcinoma, Renal Cell; Genetic Predisposition to Disease

2020

Other Studies

12 other studies available for succinic acid and Adrenal Cancer

ArticleYear
SDHB knockout and succinate accumulation are insufficient for tumorigenesis but dual SDHB/NF1 loss yields SDHx-like pheochromocytomas.
    Cell reports, 2022, 03-01, Volume: 38, Issue:9

    Topics: Adrenal Gland Neoplasms; Animals; Carcinogenesis; Cell Transformation, Neoplastic; Dioxygenases; Mic

2022
Succinate: A Serum Biomarker of SDHB-Mutated Paragangliomas and Pheochromocytomas.
    The Journal of clinical endocrinology and metabolism, 2022, 09-28, Volume: 107, Issue:10

    Topics: Adrenal Gland Neoplasms; Biomarkers, Tumor; Germ-Line Mutation; Humans; Mutation; Paraganglioma; Phe

2022
Succinate uptake by T cells suppresses their effector function via inhibition of mitochondrial glucose oxidation.
    Cell reports, 2022, 08-16, Volume: 40, Issue:7

    Topics: Adrenal Gland Neoplasms; CD8-Positive T-Lymphocytes; Cytokines; Glucose; Humans; Paraganglioma; Pheo

2022
SDHx mutation and pituitary adenoma: can in vivo 1H-MR spectroscopy unravel the link?
    Endocrine-related cancer, 2023, 02-01, Volume: 30, Issue:2

    Topics: Adenoma; Adrenal Gland Neoplasms; Germ-Line Mutation; Humans; Magnetic Resonance Spectroscopy; Mutat

2023
SDHx mutation and pituitary adenoma: can in vivo 1H-MR spectroscopy unravel the link?
    Endocrine-related cancer, 2023, 02-01, Volume: 30, Issue:2

    Topics: Adenoma; Adrenal Gland Neoplasms; Germ-Line Mutation; Humans; Magnetic Resonance Spectroscopy; Mutat

2023
SDHx mutation and pituitary adenoma: can in vivo 1H-MR spectroscopy unravel the link?
    Endocrine-related cancer, 2023, 02-01, Volume: 30, Issue:2

    Topics: Adenoma; Adrenal Gland Neoplasms; Germ-Line Mutation; Humans; Magnetic Resonance Spectroscopy; Mutat

2023
SDHx mutation and pituitary adenoma: can in vivo 1H-MR spectroscopy unravel the link?
    Endocrine-related cancer, 2023, 02-01, Volume: 30, Issue:2

    Topics: Adenoma; Adrenal Gland Neoplasms; Germ-Line Mutation; Humans; Magnetic Resonance Spectroscopy; Mutat

2023
Serum Succinate/Fumarate Ratio in Patients With Paraganglioma/Pheochromocytoma Attending an Endocrine Oncogenetic Unit.
    The Journal of clinical endocrinology and metabolism, 2023, 08-18, Volume: 108, Issue:9

    Topics: Adrenal Gland Neoplasms; Carcinogenesis; Cell Transformation, Neoplastic; Fumarates; Germ-Line Mutat

2023
Succinate detection using in vivo
    European journal of nuclear medicine and molecular imaging, 2020, Volume: 47, Issue:6

    Topics: Adrenal Gland Neoplasms; Animals; Germ-Line Mutation; Humans; Magnetic Resonance Spectroscopy; Mice;

2020
Modeling succinate dehydrogenase loss disorders in C. elegans through effects on hypoxia-inducible factor.
    PloS one, 2019, Volume: 14, Issue:12

    Topics: Adrenal Gland Neoplasms; Amino Acids, Dicarboxylic; Animals; Animals, Genetically Modified; Caenorha

2019
Hereditary pheochromocytoma/paraganglioma syndrome with a novel mutation in the succinate dehydrogenase subunit B gene in a Japanese family: two case reports.
    Journal of medical case reports, 2021, May-22, Volume: 15, Issue:1

    Topics: Adrenal Gland Neoplasms; Adult; Female; Humans; Japan; Mutation; Neoplasm Recurrence, Local; Paragan

2021
Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair.
    Nature genetics, 2018, Volume: 50, Issue:8

    Topics: Adrenal Gland Neoplasms; Cell Line; Cell Line, Tumor; Citric Acid Cycle; DNA Breaks, Double-Stranded

2018
Genotype-specific abnormalities in mitochondrial function associate with distinct profiles of energy metabolism and catecholamine content in pheochromocytoma and paraganglioma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Jul-15, Volume: 19, Issue:14

    Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Catecholamines; Electron Transport Complex II; Energy Me

2013
Succinate-to-fumarate ratio as a new metabolic marker to detect the presence of SDHB/D-related paraganglioma: initial experimental and ex vivo findings.
    Endocrinology, 2014, Volume: 155, Issue:1

    Topics: Adrenal Gland Neoplasms; Animals; Biomarkers, Tumor; Citric Acid Cycle; Female; Fumarates; Gene Expr

2014
Krebs cycle metabolite profiling for identification and stratification of pheochromocytomas/paragangliomas due to succinate dehydrogenase deficiency.
    The Journal of clinical endocrinology and metabolism, 2014, Volume: 99, Issue:10

    Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Citric Acid Cycle; Female; Follow-Up Studies; Fuma

2014