succimer and Uterine-Cervical-Neoplasms

succimer has been researched along with Uterine-Cervical-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for succimer and Uterine-Cervical-Neoplasms

Article	Year
Uptake of the 188Re(V)-DMSA complex by cervical carcinoma cells in nude mice: pharmacokinetics and dosimetry. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2001, Volume: 54, Issue:3 The uptake of the rhenium-188 (188Re(V)-DMSA) complex of dimercaptosuccinic acid by cervical carcinoma cells in nude mice was evaluated. The pharmacokinetics and dosimetry calculations in normal rats were also evaluated. The images obtained in mice did not show significant accumulation in metabolic organs and the biodistribution studies showed that 3.52 +/- 0.76% of the injected activity per gram (n = 4) was taken up by the tumor. This percentage produces a cumulated activity of 35.63 +/- 8.40 MBq h and an equivalent dose per injected activity of 260 +/- 8.91 mSv/MBq. Pharmacokinetics and dosimetry of the 1887e(V)-DMSA complex indicate that this radiopharmaceutical could be evaluated in patients with soft tissue tumors, since the risk of radiation damage to the kidney or red bone marrow could not be an obstacle for its application in therapeutic nuclear medicine. Topics: Animals; Female; HeLa Cells; Humans; Mice; Mice, Nude; Organometallic Compounds; Radiation Dosage; Radioisotopes; Radiopharmaceuticals; Rats; Rats, Wistar; Rhenium; Succimer; Tissue Distribution; Uterine Cervical Neoplasms	2001

Article

Year

Uptake of the 188Re(V)-DMSA complex by cervical carcinoma cells in nude mice: pharmacokinetics and dosimetry.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2001, Volume: 54, Issue:3

The uptake of the rhenium-188 (188Re(V)-DMSA) complex of dimercaptosuccinic acid by cervical carcinoma cells in nude mice was evaluated. The pharmacokinetics and dosimetry calculations in normal rats were also evaluated. The images obtained in mice did not show significant accumulation in metabolic organs and the biodistribution studies showed that 3.52 +/- 0.76% of the injected activity per gram (n = 4) was taken up by the tumor. This percentage produces a cumulated activity of 35.63 +/- 8.40 MBq h and an equivalent dose per injected activity of 260 +/- 8.91 mSv/MBq. Pharmacokinetics and dosimetry of the 1887e(V)-DMSA complex indicate that this radiopharmaceutical could be evaluated in patients with soft tissue tumors, since the risk of radiation damage to the kidney or red bone marrow could not be an obstacle for its application in therapeutic nuclear medicine.

Topics: Animals; Female; HeLa Cells; Humans; Mice; Mice, Nude; Organometallic Compounds; Radiation Dosage; Radioisotopes; Radiopharmaceuticals; Rats; Rats, Wistar; Rhenium; Succimer; Tissue Distribution; Uterine Cervical Neoplasms

2001