succimer and Melanoma

The flavone apigenin (APG), alone as well as in combination with other chemotherapeutic agents, is known to exhibit potential anticancer effects in various tumors and inhibit growth and metastasis of melanoma. However, the potential of apigenin nanoparticles (APG-NPs) to prevent lung colonization of malignant melanoma has not been well investigated. APG-loaded PLGA-NPs were surface-functionalized with

Topics: Animals; Apigenin; Apoptosis; Cell Culture Techniques; Cell Line, Tumor; Cell Movement; Disease Models, Animal; Drug Carriers; Drug Liberation; Female; Humans; Lung Neoplasms; Melanoma; Mice; Nanoparticles; Neoplasm Invasiveness; Particle Size; Polylactic Acid-Polyglycolic Acid Copolymer; Skin Neoplasms; Spheroids, Cellular; Succimer; Tissue Distribution