succimer and Kidney-Neoplasms

Although single photon emission computed tomography (SPECT) imaging has established a place for itself in clinical nuclear medicine for heart and brain studies, its place in renal imaging is not yet clear. Renal SPECT has been subject to limitations imposed by the efficiency of imaging equipment, and has been confined to use with static imaging agents such as technetium-99m (99mTc) dimercaptosuccinate (DMSA). SPECT has been used to investigate space-occupying lesions and anatomical abnormalities, and for quantitative studies of renal uptake and volume. In these areas, it has provided little advantage over conventional imaging, but it has been helpful in individual cases. High-resolution SPECT is a promising new development, which may have applications in detecting and classifying renal scarring. It deserves careful evaluation.

Topics: Humans; Kidney Diseases; Kidney Neoplasms; Organotechnetium Compounds; Radioisotope Renography; Succimer; Technetium Tc 99m Dimercaptosuccinic Acid; Tomography, Emission-Computed, Single-Photon

This article describes the role of nuclear medicine in the evaluation of the genitourinary tract. The technical aspects of radionuclide imaging (radiopharmaceuticals, radiation dosimetry, instrumentation, and method) are briefly presented, and each of the indications for renal scintigraphy--including the evaluation of differential renal function, hypertension, obstruction, renal transplants, masses, trauma, congenital anomalies, vesicoureteral reflux, and infection--are discussed. The relative advantages and disadvantages of radionuclide imaging with respect to alternative radiographic examinations (such as intravenous urography, ultrasonography, CT, angiography, and magnetic resonance imaging) are emphasized wherever applicable.

Topics: Graft Rejection; Humans; Hypertension, Renovascular; Iodohippuric Acid; Kidney; Kidney Function Tests; Kidney Neoplasms; Kidney Transplantation; Kidney Tubular Necrosis, Acute; Male; Organotechnetium Compounds; Pentetic Acid; Postoperative Complications; Pyelonephritis; Radioisotope Renography; Spermatic Cord Torsion; Succimer; Sugar Acids; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid; Technetium Tc 99m Pentetate; Ureteral Obstruction; Urinary Tract; Vesico-Ureteral Reflux

The diagnostic value of renal scintiscans in patients with acute or chronic renal failure has not been emphasized other than for the estimation of renal size. 131I OIH, 67gallium, 99mTcDTPA, glucoheptonate and DMSA all may be valuable in a variety of specific settings. Acute renal failure due to acute tubular necrosis, hepatorenal syndrome, acute interstitial nephritis, cortical necrosis, renal artery embolism, or acute pyelonephritis may be recognized. Data useful in the diagnosis and management of the patient with obstructive or reflux nephropathy may be obtained. Radionuclide studies in patients with chronic renal failure may help make apparent such causes as renal artery stenosis, chronic pyelonephritis or lymphomatous kidney infiltration. Future correlation of scanning results with renal pathology promises to further expand nuclear medicine's utility in the noninvasive diagnosis of renal disease.

Topics: Acute Kidney Injury; Adult; Aged; Embolism; Female; Gallium Radioisotopes; Humans; Iodine Radioisotopes; Iodohippuric Acid; Kidney Failure, Chronic; Kidney Neoplasms; Male; Middle Aged; Nephritis, Interstitial; Organotechnetium Compounds; Pentetic Acid; Pyelonephritis; Radionuclide Imaging; Renal Artery Obstruction; Succimer; Sugar Acids; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid; Technetium Tc 99m Pentetate

Scintigraphy with Tc-99m MAG3 is, to date, the most commonly used technique for evaluating separate renal function (SRF). In this study, the performance of this technique is compared to Tc-99m DMSA. A total of 37 patients with various kidney disorders (12 children and 25 adults) underwent both Tc-99m DMSA and Tc-99m MAG 3 scintigraphy. In children and adults of normal weight the correlation coefficient between the two methods was 0.99 (P < 0.001), whereas in individuals who were more than 10% overweight according to Broca, or who had abnormal anatomical positions of the kidneys, the correlation coefficient was 0.82 (P < 0.05). Scintigraphy with Tc-99m DMSA was more accurate in renal parenchyma lesions. These results indicate that Tc-99m DMSA scintigraphy is preferable for the evaluation of SRF in patients who are more than 10% overweight, or have abnormal positions of the kidneys.

Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Contraindications; Humans; Hydronephrosis; Infant; Kidney; Kidney Diseases; Kidney Neoplasms; Middle Aged; Organotechnetium Compounds; Radionuclide Imaging; Succimer; Technetium Tc 99m Dimercaptosuccinic Acid; Technetium Tc 99m Mertiatide

Topics: Brain Neoplasms; Carcinoma, Renal Cell; Humans; Kidney Neoplasms; Male; Middle Aged; Organotechnetium Compounds; Scalp; Skin Neoplasms; Succimer; Technetium Tc 99m Dimercaptosuccinic Acid; Tomography, Emission-Computed, Single-Photon

During the first 6 months of life, mesoblastic nephroma is the most common cause for a solid renal tumour. We describe two cases showing uptake of Tc99mDMSA by mesoblastic nephroma. Tc99mDMSA scanning may suggest the correct diagnosis and so allow nephrectomy without biopsy, rendering the latter unnecessary in mesoblastic nephroma.

Topics: Female; Humans; Infant, Newborn; Kidney; Kidney Neoplasms; Male; Organotechnetium Compounds; Radionuclide Imaging; Succimer; Technetium Tc 99m Dimercaptosuccinic Acid; Ultrasonography; Wilms Tumor

Topics: Biopsy; Diagnosis, Differential; Humans; Kidney Neoplasms; Nephrectomy; Organotechnetium Compounds; Preoperative Care; Succimer; Technetium Tc 99m Dimercaptosuccinic Acid; Wilms Tumor

We report a case of nonfunction of an anatomically normal kidney associated with a contralateral hypernephroma. X-ray and radionuclide imaging suggested a disturbance of the contralateral renal blood flow at the microvascular level. Normal function resumed after tumor resection. The implications for management are discussed.

Topics: Carcinoma, Renal Cell; Female; Humans; Kidney; Kidney Neoplasms; Middle Aged; Nephrectomy; Organotechnetium Compounds; Radiography; Radioisotope Renography; Succimer; Technetium Tc 99m Dimercaptosuccinic Acid; Ultrasonography

Topics: Adenocarcinoma; Humans; Kidney Neoplasms; Male; Middle Aged; Organometallic Compounds; Radionuclide Imaging; Skin Neoplasms; Succimer; Sulfhydryl Compounds; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid

Topics: Adult; Animals; Female; Humans; Iodohippuric Acid; Kidney Neoplasms; Male; Middle Aged; Organometallic Compounds; Radioisotope Renography; Succimer; Technetium Tc 99m Dimercaptosuccinic Acid

Topics: Humans; Kidney Neoplasms; Organometallic Compounds; Radionuclide Imaging; Succimer; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid; Ultrasonography

Topics: Adenocarcinoma; Aged; Female; Humans; Kidney Diseases, Cystic; Kidney Neoplasms; Male; Middle Aged; Pentetic Acid; Radionuclide Imaging; Succimer; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid; Technetium Tc 99m Pentetate; Urography

Topics: Bone Neoplasms; Carcinoma, Renal Cell; Humans; Kidney Neoplasms; Male; Middle Aged; Radionuclide Imaging; Succimer; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid

Being aware of the ideal nuclear properties of Tc-99m, our interest has been focused on the design of the (+5) oxidation state Tc-99m(V) dimercaptosuccinic acid (Tc(V)-DMSA) as a tumor-seeking agent. Tc-99m(V) DMSA holds a TcO4(3-) core and, like PO4(3-), has excellent characteristics for tumor uptake, but has a different distribution than the well-known renal scanning agent, Tc-99m DMSA. The differences in chemical behavior of Tc-99m(V) DMSA and Tc-99m DMSA are discussed. Three cases in which neoplasms were studies with Tc-99m(V) DMSA and Tc-99m DMSA are presented. Tc-99m DMSA and Tc-99m(V) DMSA, having a common ligand and tracer but, with the metal ion core in a different oxidation state, the uptake characteristics are altered markedly.

Topics: Adrenal Gland Neoplasms; Carcinoma, Renal Cell; Humans; Kidney Neoplasms; Male; Middle Aged; Nasopharyngeal Neoplasms; Neoplasms; Radionuclide Imaging; Succimer; Sulfhydryl Compounds; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid

Juxtaglomerular cell tumor is a rare condition which cannot be correctly diagnosed preoperatively. In the only previously reported case in which scintigraphy has been used, this method failed to detect the tumor. We present a case of juxtaglomerular cell tumor in which renal scintigraphy revealed a well-defined cold area in the hilar region of the left kidney.

Topics: Adolescent; Female; Humans; Juxtaglomerular Apparatus; Kidney; Kidney Neoplasms; Radionuclide Imaging; Succimer; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid

Single photon emission computed tomography (SPECT), recently introduced into clinical nuclear medicine, potentially offers improved spatial resolution compared to planar imaging by eliminating activity from surrounding structures, and permitting three-dimensional reconstructions. Its clinical applications to date have been limited. A case where SPECT with Tc-99m dimercaptosuccinic acid (DMSA) better demonstrated a renal pseudotumor (a benign column of Bertin) compared to planar imaging is reported.

Topics: Adult; Diagnosis, Differential; Humans; Kidney Cortex; Kidney Neoplasms; Male; Succimer; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid; Tomography, Emission-Computed

A total of 127 patients were examined to determine the efficacy of the use of sonography, angionephroscintigraphy and roentgenocontrast angiography in renal tumors and the importance of these methods in diagnostic studies with suspicion for a renal tumor. All the patients were given ultrasound and radionuclide examination, 86 roentgenocontrast angiography. The study has shown a high sensitivity of all three methods in the diagnosis of sizable renal lesions though each one has a different diagnostic tendency. In vascularized tumors the combined use of sonography and angionephroscintigraphy practically ensures 100% diagnosis in a patient even at the out-patient stage of examination. The main difficulties occur in the differential diagnosis of hypovascular sizable tumors when the comparison of the results of all three methods makes it possible to establish correct diagnosis. The advantage of sonography is the absence of traumatism, that of angiography a possibility to determine the functional activity of both involved and intact kidneys. Roentgenocontrast angiography plays the leading role in defining the involvement of the renal and cava inferior veins by a tumor thrombus.

Topics: Adult; Angiography; Cysts; Diagnosis, Differential; Diagnostic Errors; Female; Humans; Kidney; Kidney Diseases; Kidney Neoplasms; Male; Middle Aged; Radioisotope Renography; Succimer; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid; Ultrasonography

Topics: Aged; Bone Neoplasms; Carcinoma, Renal Cell; Humans; Kidney Neoplasms; Male; Radionuclide Imaging; Renal Artery; Succimer; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid

Topics: Adenocarcinoma; Bone Neoplasms; Humans; Kidney Neoplasms; Male; Middle Aged; Radionuclide Imaging; Succimer; Sulfhydryl Compounds; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid

Topics: Adult; Aged; Diagnostic Errors; Humans; Kidney Diseases, Cystic; Kidney Neoplasms; Male; Radionuclide Imaging; Succimer; Sulfhydryl Compounds; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid; Tomography, X-Ray Computed; Ultrasonography

Topics: Adenocarcinoma; Adult; Aged; Bone and Bones; Diphosphonates; Female; Gallium Radioisotopes; Humans; Kidney; Kidney Neoplasms; Male; Middle Aged; Radionuclide Imaging; Succimer; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid; Technetium Tc 99m Medronate

Experiences are reported on renal imaging with 99mTc-dimercaptosuccinic acid (DMSA) in pediatric nephrology. Because of its low radiation dose, the use of 99mTc-DMSA has advantages in infancy and childhood, while the considerable accumulation of this compound in the renal cortex results in more informative imaging than with other 99mTc-complexes. Not only can the shape, size and position of the kidneys, and the location and extent of renal tumors, cysts and abscesses be visualized, but as a complement to excretory urography this technique contributes even in pyelonephritis to the precise determination of parenchymal damage.

Topics: Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Kidney; Kidney Cortex; Kidney Diseases, Cystic; Kidney Neoplasms; Male; Pyelonephritis; Radiation Dosage; Radionuclide Imaging; Succimer; Sulfhydryl Compounds; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid

Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Female; Humans; Iodohippuric Acid; Kidney; Kidney Diseases; Kidney Neoplasms; Male; Middle Aged; Nephrectomy; Radiography; Radionuclide Imaging; Succimer; Sulfhydryl Compounds; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid

Topics: Adolescent; Adult; Aged; Humans; Iodohippuric Acid; Kidney Diseases; Kidney Function Tests; Kidney Neoplasms; Middle Aged; Radionuclide Imaging; Succimer; Sulfhydryl Compounds; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid

Topics: Adenocarcinoma; Hemangioma; Humans; Kidney Cortex; Kidney Diseases; Kidney Diseases, Cystic; Kidney Neoplasms; Lipoma; Radionuclide Imaging; Succimer; Sulfhydryl Compounds; Technetium

Topics: False Positive Reactions; Humans; Hypertrophy; Kidney Cortex; Kidney Neoplasms; Pentetic Acid; Radionuclide Imaging; Succimer; Technetium

Topics: Carcinoma, Bronchogenic; Humans; Kidney Cortex; Kidney Neoplasms; Lung Neoplasms; Neoplasm Metastasis; Radionuclide Imaging; Succimer; Sulfhydryl Compounds; Technetium

43 patients underwent an extended scintigraphic procedure with 99mTc-dimercaptosuccinylic acid in order to investigate its proper use for diagnosing morphological and functional kidney abnormalities. The group was comprised of patients without renal disease, and patients with diffuse parenchymal disease, obstructive uropathy, renal cysts and renal tumors. The study was followed by 131I-hippurate renography. We propose a simplified routine procedure with scintiphotos taken 10-15 min after injection for topographic information and 120 min after injection for renal morphology. This procedure allows excellent case finding of diffuse parenchymal disease of a special value in cases of radiological non-visualization. The technique is indicated, when iodine contrast media cannot be used for radiological examinations. DMSA studies, however, do not allow safe functional evaluation in all categories of patients. Neither can obstructive nephropathy be diagnosed unless the renal pelvis is dilated. Renal perfusion studies are contaminated by the perfusion of liver and spleen. Nevertheless, a tentative differentiation between cysts and tumours is possible, the former being hypoperfused the latter hyperperfused. When supplemented with gamma camera 131I-hippurate renography, the total scintigraphic procedure will also include split function determination and run-off evaluation.

Topics: Humans; Iodine Radioisotopes; Iodohippuric Acid; Kidney; Kidney Diseases; Kidney Diseases, Cystic; Kidney Neoplasms; Pyelonephritis; Radioisotope Renography; Succimer; Sulfhydryl Compounds; Technetium; Ureteral Obstruction

The basic non-invasive investigation of renal space occupying lesions by excretion pyelography was coupled with ultrasonic scanning. Forty-one patients who have undergone isotopic section scanning as part of their investigative assessment were studied. The conditions investigated included solitary cysts, polycystic kidneys, renal tumours, tumefactive xanthomatous pyelonephritis, renal infarct and non-functioning kidneys. An analysis of the accuracy of isotopic section scanning in these different pathological states was made. Computerised isotopic section renal scanning offers a new non-invasive renal investigative technique.

Topics: Adult; Aged; Computers; Female; Humans; Kidney Diseases; Kidney Diseases, Cystic; Kidney Neoplasms; Male; Middle Aged; Radionuclide Imaging; Succimer; Technetium

Topics: Adenocarcinoma; Aortography; Humans; Kidney Cortex; Kidney Neoplasms; Male; Middle Aged; Radionuclide Imaging; Renal Artery; Succimer; Sulfhydryl Compounds; Technetium