succimer and Kidney-Diseases--Cystic

Infantile renal dysplasias, including multicystic dysplastic kidneys (MCDK), are reported rarely to accumulate radiopharmaceuticals on renal scintigraphy. 99mTc DMSA is a highly sensitive tracer for detecting functioning renal cortical tissue and may be more suited to studying renal dysplasia than 99mTc DTPA. We reviewed the ultrasound studies and 99mTc DMSA scintigrams of 42 infants (age range 1-12 months) with known or suspected MCDK. Overall, uptake on 99mTc DMSA scintigraphy was evident in 6/41 (15%) dysplastic kidneys. Of the 18 patients who underwent nephrectomy, histopathological examination revealed that uptake correlated closely with the presence of mature renal cortical tissue in the affected kidney. Our study shows that a small, but significant number of MCDK will show low-grade uptake on DMSA scintigraphy. This finding may be relevant given the reliance placed on renal scintigraphy in planning treatment for infants with suspected MCDK, particularly with the increasing trend for the non-operative management of this condition.

Topics: Female; Humans; Infant; Kidney; Kidney Diseases, Cystic; Male; Organotechnetium Compounds; Radionuclide Imaging; Succimer; Technetium Tc 99m Dimercaptosuccinic Acid

Topics: Adenocarcinoma; Aged; Female; Humans; Kidney Diseases, Cystic; Kidney Neoplasms; Male; Middle Aged; Pentetic Acid; Radionuclide Imaging; Succimer; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid; Technetium Tc 99m Pentetate; Urography

Ultrasound-guided renal cyst puncture was performed on 31 cysts which were then 95% ethanol instilled to prevent recurrence of cystic fluid. Ethanol was allowed to remain in place for 20 minutes and removed through the catheter. Morphological improvement was observed on IVP and Tc-99m-DMSA renal scintigram, and DMSA renal uptake rate increased slightly. The cystic wall became thicker, and cystic fluid did not remain any more. The renal tissue near the cyst was intact. One third of the patients had hotflush and/or somewhat drunken sense but these symptoms were only temporary. This method of therapy is a safe and effective way of treating renal cysts.

Topics: Adult; Aged; Cytodiagnosis; Ethanol; Humans; Infant; Kidney; Kidney Diseases, Cystic; Male; Middle Aged; Punctures; Radionuclide Imaging; Succimer; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid; Ultrasonography

Topics: Adult; Aged; Diagnostic Errors; Humans; Kidney Diseases, Cystic; Kidney Neoplasms; Male; Radionuclide Imaging; Succimer; Sulfhydryl Compounds; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid; Tomography, X-Ray Computed; Ultrasonography

Experiences are reported on renal imaging with 99mTc-dimercaptosuccinic acid (DMSA) in pediatric nephrology. Because of its low radiation dose, the use of 99mTc-DMSA has advantages in infancy and childhood, while the considerable accumulation of this compound in the renal cortex results in more informative imaging than with other 99mTc-complexes. Not only can the shape, size and position of the kidneys, and the location and extent of renal tumors, cysts and abscesses be visualized, but as a complement to excretory urography this technique contributes even in pyelonephritis to the precise determination of parenchymal damage.

Topics: Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Kidney; Kidney Cortex; Kidney Diseases, Cystic; Kidney Neoplasms; Male; Pyelonephritis; Radiation Dosage; Radionuclide Imaging; Succimer; Sulfhydryl Compounds; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid

Topics: Adenocarcinoma; Hemangioma; Humans; Kidney Cortex; Kidney Diseases; Kidney Diseases, Cystic; Kidney Neoplasms; Lipoma; Radionuclide Imaging; Succimer; Sulfhydryl Compounds; Technetium

Topics: Adult; Bone Neoplasms; Child; Humans; Hydronephrosis; Iodine Radioisotopes; Iodohippuric Acid; Kidney; Kidney Diseases; Kidney Diseases, Cystic; Male; Pentetic Acid; Prostatic Neoplasms; Radioisotope Renography; Succimer; Technetium

Topics: Humans; Kidney Diseases, Cystic; Male; Middle Aged; Radionuclide Imaging; Succimer; Sulfhydryl Compounds; Technetium; Urine

43 patients underwent an extended scintigraphic procedure with 99mTc-dimercaptosuccinylic acid in order to investigate its proper use for diagnosing morphological and functional kidney abnormalities. The group was comprised of patients without renal disease, and patients with diffuse parenchymal disease, obstructive uropathy, renal cysts and renal tumors. The study was followed by 131I-hippurate renography. We propose a simplified routine procedure with scintiphotos taken 10-15 min after injection for topographic information and 120 min after injection for renal morphology. This procedure allows excellent case finding of diffuse parenchymal disease of a special value in cases of radiological non-visualization. The technique is indicated, when iodine contrast media cannot be used for radiological examinations. DMSA studies, however, do not allow safe functional evaluation in all categories of patients. Neither can obstructive nephropathy be diagnosed unless the renal pelvis is dilated. Renal perfusion studies are contaminated by the perfusion of liver and spleen. Nevertheless, a tentative differentiation between cysts and tumours is possible, the former being hypoperfused the latter hyperperfused. When supplemented with gamma camera 131I-hippurate renography, the total scintigraphic procedure will also include split function determination and run-off evaluation.

Topics: Humans; Iodine Radioisotopes; Iodohippuric Acid; Kidney; Kidney Diseases; Kidney Diseases, Cystic; Kidney Neoplasms; Pyelonephritis; Radioisotope Renography; Succimer; Sulfhydryl Compounds; Technetium; Ureteral Obstruction

The basic non-invasive investigation of renal space occupying lesions by excretion pyelography was coupled with ultrasonic scanning. Forty-one patients who have undergone isotopic section scanning as part of their investigative assessment were studied. The conditions investigated included solitary cysts, polycystic kidneys, renal tumours, tumefactive xanthomatous pyelonephritis, renal infarct and non-functioning kidneys. An analysis of the accuracy of isotopic section scanning in these different pathological states was made. Computerised isotopic section renal scanning offers a new non-invasive renal investigative technique.

Topics: Adult; Aged; Computers; Female; Humans; Kidney Diseases; Kidney Diseases, Cystic; Kidney Neoplasms; Male; Middle Aged; Radionuclide Imaging; Succimer; Technetium