succimer and Carcinoma--Renal-Cell

Topics: Brain Neoplasms; Carcinoma, Renal Cell; Humans; Kidney Neoplasms; Male; Middle Aged; Organotechnetium Compounds; Scalp; Skin Neoplasms; Succimer; Technetium Tc 99m Dimercaptosuccinic Acid; Tomography, Emission-Computed, Single-Photon

We report a case of nonfunction of an anatomically normal kidney associated with a contralateral hypernephroma. X-ray and radionuclide imaging suggested a disturbance of the contralateral renal blood flow at the microvascular level. Normal function resumed after tumor resection. The implications for management are discussed.

Topics: Carcinoma, Renal Cell; Female; Humans; Kidney; Kidney Neoplasms; Middle Aged; Nephrectomy; Organotechnetium Compounds; Radiography; Radioisotope Renography; Succimer; Technetium Tc 99m Dimercaptosuccinic Acid; Ultrasonography

Topics: Bone Neoplasms; Carcinoma, Renal Cell; Humans; Kidney Neoplasms; Male; Middle Aged; Radionuclide Imaging; Succimer; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid

Being aware of the ideal nuclear properties of Tc-99m, our interest has been focused on the design of the (+5) oxidation state Tc-99m(V) dimercaptosuccinic acid (Tc(V)-DMSA) as a tumor-seeking agent. Tc-99m(V) DMSA holds a TcO4(3-) core and, like PO4(3-), has excellent characteristics for tumor uptake, but has a different distribution than the well-known renal scanning agent, Tc-99m DMSA. The differences in chemical behavior of Tc-99m(V) DMSA and Tc-99m DMSA are discussed. Three cases in which neoplasms were studies with Tc-99m(V) DMSA and Tc-99m DMSA are presented. Tc-99m DMSA and Tc-99m(V) DMSA, having a common ligand and tracer but, with the metal ion core in a different oxidation state, the uptake characteristics are altered markedly.

Topics: Adrenal Gland Neoplasms; Carcinoma, Renal Cell; Humans; Kidney Neoplasms; Male; Middle Aged; Nasopharyngeal Neoplasms; Neoplasms; Radionuclide Imaging; Succimer; Sulfhydryl Compounds; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid

Topics: Aged; Bone Neoplasms; Carcinoma, Renal Cell; Humans; Kidney Neoplasms; Male; Radionuclide Imaging; Renal Artery; Succimer; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid