succimer and Amyloidosis

A 31-year-old male having familial amyloid polyneuropathy underwent a Tc-99m(V)-DMSA study to evaluate the myocardial involvement. The patient also underwent T1-201, I-123-BMIPP and I-123-MIBG myocardial SPECT studies to evaluate blood perfusion, fatty acid metabolism and sympathetic function of the heart, respectively. Tc-99m(V)-DMSA SPECT showed uptake to the myocardium indicating myocardial involvement of amyloidosis. Both T1-201 and I-123-BMIPP studies showed normal uptake indicating normal blood perfusion and fatty acid metabolism but I-123-MIBG SPECT showed no uptake to the heart, indicating severe impairment of sympathetic function.

Topics: 3-Iodobenzylguanidine; Adult; Amyloid Neuropathies; Amyloidosis; Cardiomyopathies; Coronary Circulation; Fatty Acids; Humans; Iodine Radioisotopes; Iodobenzenes; Male; Organotechnetium Compounds; Succimer; Technetium Tc 99m Dimercaptosuccinic Acid; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon

Topics: Adult; Amyloidosis; Humans; Male; Organotechnetium Compounds; Radionuclide Imaging; Succimer; Technetium Tc 99m Dimercaptosuccinic Acid

This report describes the localization and categorization of tumors using Ga-67 and Tc-99m (V) DMSA imaging in a rare case of non-Hodgkin's lymphoma associated with an amyloid tumor. Ga-67 uptake was found in both the lymphoma and the amyloid tumor. Significant Tc-99m (V) DMSA uptake was found only in the amyloid tumor. In this case, Ga-67 uptake was nonspecific, but Tc-99m (V) DMSA uptake gave additional information before treatment.

Topics: Adult; Amyloidosis; Gallium Radioisotopes; Humans; Lymphoma, Follicular; Male; Neck; Organotechnetium Compounds; Radionuclide Imaging; Succimer; Technetium Tc 99m Dimercaptosuccinic Acid

Topics: Aged; Aged, 80 and over; Amyloidosis; Cardiomyopathies; Heart; Humans; Male; Multiple Myeloma; Organotechnetium Compounds; Radionuclide Imaging; Succimer; Technetium Tc 99m Dimercaptosuccinic Acid

Technetium-99m(V)dimercaptosuccinic acid (DMSA) scintigraphy was performed in two patients with pathologically confirmed primary amyloidosis. Both patients had tumor-like deposits of AL-type amyloid in the abdomen. Marked uptake of the tracer by the amyloid deposits was noted. Technetium-99m-(V)DMSA scintigraphy appears to be useful in detecting the distribution of amyloid deposits and in determining the appropriate site for biopsy.

Topics: Abdomen; Aged; Amyloid; Amyloidosis; Female; Humans; Male; Middle Aged; Organotechnetium Compounds; Radionuclide Imaging; Succimer; Technetium Tc 99m Dimercaptosuccinic Acid

Tc-99m(V) DMSA scintigraphy was performed on two patients with primary cardiac amyloidosis. Scintigraphy performed (after radionuclide administration) showed accumulation in the myocardium.

Topics: Amyloidosis; Cardiomyopathies; Heart; Humans; Male; Middle Aged; Organotechnetium Compounds; Succimer; Technetium Tc 99m Dimercaptosuccinic Acid; Technetium Tc 99m Pyrophosphate; Tomography, Emission-Computed, Single-Photon

Topics: Amyloidosis; Female; Humans; Middle Aged; Organotechnetium Compounds; Radionuclide Imaging; Succimer; Technetium Tc 99m Dimercaptosuccinic Acid; Thyroid Diseases

Technetium-99m(V) DMSA scintigraphy was performed in two patients with pathologically confirmed amyloidosis associated with plasmacytoma. Significant uptake of the tracer was found in the deposition of amyloid. Technetium-99m(V) DMSA scintigraphy could be useful in determining the appropriate region of biopsy and in forecasting the prognosis of patient with plasmacytoma.

Topics: Aged; Aged, 80 and over; Amyloidosis; Female; Humans; Laryngeal Neoplasms; Organotechnetium Compounds; Paranasal Sinus Neoplasms; Plasmacytoma; Radionuclide Imaging; Succimer; Sulfhydryl Compounds; Technetium Tc 99m Dimercaptosuccinic Acid