substance p has been researched along with Vomiting in 65 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.54) | 18.7374 |
| 1990's | 10 (15.38) | 18.2507 |
| 2000's | 33 (50.77) | 29.6817 |
| 2010's | 18 (27.69) | 24.3611 |
| 2020's | 3 (4.62) | 2.80 |
| Authors | Studies |
|---|---|
| Arya, M; Chaithra, SN; Dhama, K; Dixit, SK; Jambagi, K; Patel, PK; Sharun, K | 1 |
| Guo, X; Qin, Z; Wei, B; Wu, Q; Wu, R; Wu, W; Xiao, H; Zhang, H | 1 |
| An, HJ; Cho, SS; Kim, HH; Ko, YH; Park, HS; Shim, BY; Sun, S; Won, HS | 1 |
| Fabi, A; Malaguti, P | 1 |
| Egashira, N; Kawashiri, T; Oishi, R; Yano, T | 1 |
| Alkam, T; Chebolu, S; Darmani, NA | 1 |
| Coveñas, R; Muñoz, M | 1 |
| Du, XP; Han, ZX; Ma, J; Sun, X; Wang, HM; Xu, J | 1 |
| Boland, JW; Kyeremateng, S | 1 |
| Molasiotis, A; Raftopoulos, H; Rapoport, BL; Roila, F | 1 |
| Chebolu, S; Darmani, NA; Zhong, W | 1 |
| Bosnjak, SM; Dimitrijevic, J; Djordjevic, F | 1 |
| Duffy, RA; Lachowicz, JE; Nomeir, AA; Paliwal, S; Reichard, GA; Shah, S; Shih, NY; Stengone, C; Tsui, HC; Varty, GB; Wang, C; Wrobleski, ML; Xiao, D | 1 |
| Darmani, NA; Griggs, L; Ray, AP | 1 |
| Abad, J; Crim, JL; Darmani, NA; Janoyan, JJ; Ramirez, J | 1 |
| Grunberg, S; Hawkins, R | 1 |
| Chen, WH; Liu, ZT; Qian, QH; Wang, YX; Yang, ZH; Yue, W | 2 |
| Chebolu, S; Darmani, NA; Ramirez, J; Ray, AP | 1 |
| Darmani, NA; Ray, AP | 1 |
| Chebolu, S; Darmani, NA; Ray, AP | 1 |
| Abad, J; Darmani, NA; Dey, D; Ray, AP | 1 |
| Bonneterre, J; Mailliez, A | 1 |
| Higa, GM; Trigg, ME | 1 |
| Alt, J; Cantoreggi, S; Li, Y; Pietra, C; Rojas, C; Sebastiani, S; Slusher, BS; Stathis, M; Thomas, AG; Zhang, J | 1 |
| Endo, M; Murakami, H; Nakamura, Y; Takahashi, T; Tsuya, A; Yamamoto, N | 1 |
| Alkam, T; Amos, B; Chebolu, S; Darmani, NA | 1 |
| Auber, ML; Higa, GM; Hobbs, G | 1 |
| Alkam, T; Amos, B; Chebolu, S; Darmani, NA; Dey, D; Kandpal, R | 1 |
| Kakuta, S; Oda, S; Tanihata, S; Uchiyama, T | 1 |
| Kamiya, HO; Saito, R; Takano, Y | 1 |
| Aapro, M; Carides, AD; Evans, JK; Hargreaves, R; Hesketh, PJ; Horgan, KJ; Naylor, RJ; Tattersall, FD; Van Belle, S | 1 |
| Stahl, SM | 2 |
| Heinzl, S | 1 |
| Olver, IN | 1 |
| Duffy, RA | 1 |
| Batra, U; Chen, C; Hettrick, L; Higgins, R; Kwei, G; Landis, E; Loper, A; Lynn, K; Novak, L; Shelukar, S; Storey, D; Thompson, K; Wu, Y | 1 |
| Hesketh, PJ | 2 |
| Gerspacher, M | 1 |
| Prommer, E | 1 |
| Altaha, R; Auber, ML; Higa, GM; Hobbs, G; Kurian, S; Landreth, K; Piktel, D | 1 |
| Hartvig, P | 1 |
| Nieber, K; Schoppmeyer, K | 1 |
| Asai, H; Ishii, T; Kiuchi, S; Nagasaki, M; Okamoto, M; Saito, A; Taniguchi, H; Watanabe, Y | 1 |
| Abad, J; Darmani, NA; Ramirez, J; Ray, AP; Thrush, GR; Wang, Y | 1 |
| Abadías, M; Arañó, P; Conejero, J; Martínez-García, R; Perales, L; Ruíz, JL; Sust, M | 1 |
| Bountra, C; Bunce, K; Dale, T; Gardner, C; Jordan, C; Twissell, D; Ward, P | 1 |
| Cascieri, M; Hargreaves, RJ; Hill, RG; Marmont, N; Rycroft, W; Tattersall, FD | 1 |
| Herrstedt, J | 1 |
| Endo, T; Hirafuji, M; Minami, M | 1 |
| Field, MJ; Hughes, J; Kuo, BS; Naylor, RJ; Singh, L; Suman-Chauhan, N; Tuladhar, BR; Wright, DS | 1 |
| Lucot, JB; McLean, S; Obach, RS; Watson, JW | 1 |
| Saphir, A | 1 |
| Ariumi, H; Hashiguchi, T; Hori, N; Kamiya, H; Migita, K; Saeki, M; Saito, R; Sakai, M; Suehiro, Y; Takano, Y | 1 |
| O'Sullivan, GC; Shanahan, F | 1 |
| Ariumi, H; Hyakusoku, M; Kamiya, H; Nago, S; Saito, R; Takano, Y | 1 |
| Andrews, P; Dovey, E; Hockaday, J; Hoyle, CH; Matsuki, N; Woods, AJ | 1 |
| Bleiberg, H | 1 |
| Diemunsch, P; Grélot, L | 1 |
| Boulet, L; Lamontagne, S; Luk, P; Meadows, E; Metters, KM; Muise, E; Nantel, F; Normandin, D; Pon, DJ; Robertson, GS; Robichaud, A | 1 |
| Chan, CC; Jolicoeur, P; Lachance, N; Rasori, R; Robichaud, A; Savoie, C; Stamatiou, PB | 1 |
| Maley, B; Newton, BW; Traurig, H | 1 |
22 review(s) available for substance p and Vomiting
| Article | Year |
|---|---|
Clinical Applications of Substance P (Neurokinin-1 Receptor) Antagonist in Canine Medicine.
Topics: Animals; Antiemetics; Dogs; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Substance P; Vomiting | 2021 |
An update on palonosetron hydrochloride for the treatment of radio/chemotherapy-induced nausea and vomiting.
Topics: Animals; Antiemetics; Antineoplastic Agents; Drug Therapy, Combination; Humans; Isoquinolines; Nausea; Neurokinin-1 Receptor Antagonists; Palonosetron; Practice Guidelines as Topic; Quinuclidines; Radiotherapy; Serotonin 5-HT3 Receptor Antagonists; Substance P; Treatment Outcome; Vomiting | 2013 |
Involvement of substance P and the NK-1 receptor in human pathology.
Topics: Alcoholism; Animals; Bacterial Infections; Depression; Humans; Inflammation; Migraine Disorders; Neoplasms; Pain; Receptors, Neurokinin-1; Seizures; Stress, Psychological; Substance P; Virus Diseases; Vomiting | 2014 |
Cancer and chemotherapy-induced nausea and vomiting: a focus on olanzapine.
Topics: Antiemetics; Antineoplastic Agents; Benzodiazepines; Clinical Trials, Phase III as Topic; Drug Therapy, Combination; Humans; Nausea; Neoplasms; Neurokinin-1 Receptor Antagonists; Olanzapine; Substance P; Vomiting | 2016 |
Chemotherapy-induced nausea and vomiting: challenges and opportunities for improved patient outcomes.
Topics: Antiemetics; Antineoplastic Agents; Humans; Metoclopramide; Nausea; Neoplasms; Substance P; Treatment Outcome; Vomiting | 2009 |
Evidence for a re-evaluation of the neurochemical and anatomical bases of chemotherapy-induced vomiting.
Topics: Antineoplastic Agents; Cannabinoids; Dopamine; Eicosanoids; Gastrointestinal Tract; Humans; Neoplasms; Nervous System; Serotonin; Substance P; Vomiting | 2009 |
[Chemotherapy induced emesis: pathophysiology and prevention].
Topics: Adrenal Cortex Hormones; Antiemetics; Antineoplastic Agents; Dopamine Antagonists; Humans; Nausea; Receptors, Tachykinin; Serotonin; Serotonin Antagonists; Substance P; Vomiting | 2010 |
Chemotherapy-induced nausea and vomiting: antiemetic trials that impacted clinical practice.
Topics: Animals; Antiemetics; Antineoplastic Agents; Drug Therapy, Combination; Glucocorticoids; Humans; Nausea; Neurokinin-1 Receptor Antagonists; Practice Guidelines as Topic; Serotonin; Serotonin 5-HT3 Receptor Antagonists; Serotonin Antagonists; Substance P; Vomiting | 2010 |
Roles of substance P and NK(1) receptor in the brainstem in the development of emesis.
Topics: Animals; Area Postrema; Brain Stem; Humans; Neurotransmitter Agents; Receptors, Neurokinin-1; Solitary Nucleus; Substance P; Vomiting | 2003 |
Differential involvement of neurotransmitters through the time course of cisplatin-induced emesis as revealed by therapy with specific receptor antagonists.
Topics: Antiemetics; Antineoplastic Agents; Aprepitant; Cisplatin; Clinical Trials, Phase II as Topic; Drug Therapy, Combination; Granisetron; Humans; Morpholines; Neoplasms; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Ondansetron; Prodrugs; Serotonin; Serotonin Antagonists; Substance P; Vomiting | 2003 |
[Neurokinin antagonists as antiemetics].
Topics: Antiemetics; Antineoplastic Agents; Clinical Trials as Topic; Humans; Neurokinin-1 Receptor Antagonists; Substance P; Vomiting | 2003 |
Aprepitant in antiemetic combinations to prevent chemotherapy-induced nausea and vomiting.
Topics: Antiemetics; Antineoplastic Agents; Aprepitant; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Male; Morpholines; Substance P; Tomography, Emission-Computed; Vomiting | 2004 |
Potential therapeutic targets for neurokinin-1 receptor antagonists.
Topics: Analgesics; Anti-Anxiety Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Antiemetics; Antineoplastic Agents; Antitussive Agents; Anxiety; Asthma; Clinical Trials as Topic; Cough; Cystitis; Depression; Drug Design; Humans; Inflammation; Irritable Bowel Syndrome; Neoplasms; Neurokinin-1 Receptor Antagonists; Pain; Substance P; Vomiting | 2004 |
Understanding the pathobiology of chemotherapy-induced nausea and vomiting. Providing a basis for therapeutic progress.
Topics: Antiemetics; Drug-Related Side Effects and Adverse Reactions; Humans; Models, Biological; Nausea; Neurokinin-1 Receptor Antagonists; Serotonin; Serotonin Receptor Agonists; Substance P; Vomiting | 2004 |
Selective and combined neurokinin receptor antagonists.
Topics: Animals; Central Nervous System Diseases; Drug Combinations; Gastrointestinal Diseases; Humans; Lung Diseases; Neurokinin A; Neurokinin B; Pain; Receptors, Tachykinin; Substance P; Urologic Diseases; Vomiting | 2005 |
Aprepitant (EMEND): the role of substance P in nausea and vomiting.
Topics: Animals; Antiemetics; Antineoplastic Agents; Aprepitant; Cisplatin; Clinical Trials as Topic; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Liver; Morpholines; Nausea; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Substance P; Vomiting | 2005 |
[Prevention of nausea and vomiting. Aprepitant, the first therapeutic acting NK-1 receptor antagonist].
Topics: Animals; Antiemetics; Antineoplastic Agents; Aprepitant; Humans; Morpholines; Nausea; Neurokinin-1 Receptor Antagonists; Substance P; Vomiting | 2007 |
New perspectives in antiemetic treatment.
Topics: Antiemetics; Antineoplastic Agents; Humans; Nausea; Serotonin; Serotonin Antagonists; Substance P; Vomiting | 1996 |
[Role of serotonin in emesis].
Topics: Afferent Pathways; Animals; Brain Stem; Cisplatin; Humans; Intestinal Mucosa; Mice; Nausea; Rats; Receptors, Opioid; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Substance P; Vagus Nerve; Vomiting | 1996 |
A new class of antiemetics: the NK-1 receptor antagonists.
Topics: Animals; Antiemetics; Antineoplastic Agents; Clinical Trials as Topic; Humans; Neoplasms; Neurokinin-1 Receptor Antagonists; Substance P; Vomiting | 2000 |
Potential of substance P antagonists as antiemetics.
Topics: Antiemetics; Clinical Trials as Topic; Humans; Infusions, Intravenous; Receptors, Neurokinin-1; Substance P; Vomiting | 2000 |
Potential role of the NK1 receptor antagonists in chemotherapy-induced nausea and vomiting.
Topics: Antiemetics; Antineoplastic Agents; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Nausea; Receptors, Neurokinin-1; Substance P; Vomiting | 2001 |
3 trial(s) available for substance p and Vomiting
| Article | Year |
|---|---|
Pharmacokinetics of aprepitant and dexamethasone after administration of chemotherapeutic agents and effects of plasma substance P concentration on chemotherapy-induced nausea and vomiting in Japanese cancer patients.
Topics: Adult; Aged; Anti-Inflammatory Agents; Antiemetics; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aprepitant; Area Under Curve; Carcinoma, Non-Small-Cell Lung; Dexamethasone; Drug Therapy, Combination; Female; Granisetron; Humans; Immunoenzyme Techniques; Japan; Lung Neoplasms; Male; Mesothelioma; Middle Aged; Morpholines; Nausea; Small Cell Lung Carcinoma; Substance P; Vomiting; Young Adult | 2011 |
5-Hydroxyindoleacetic acid and substance P profiles in patients receiving emetogenic chemotherapy.
Topics: Adult; Aged; Analysis of Variance; Antiemetics; Antineoplastic Agents; Biomarkers; Chromatography, High Pressure Liquid; Cisplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Hydroxyindoleacetic Acid; Immunoassay; Male; Middle Aged; Nausea; Prospective Studies; Substance P; Time Factors; Vomiting | 2006 |
Cizolirtine citrate, an effective treatment for symptomatic patients with urinary incontinence secondary to overactive bladder: a pilot dose-finding study.
Topics: Adult; Aged; Aged, 80 and over; Calcitonin Gene-Related Peptide; Dizziness; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Middle Aged; Nausea; Pilot Projects; Pyrazoles; Substance P; Urinary Bladder, Overactive; Urinary Incontinence; Urodynamics; Vision Disorders; Vomiting; Young Adult | 2009 |
40 other study(ies) available for substance p and Vomiting
| Article | Year |
|---|---|
Glucose-Dependent Insulinotropic Polypeptide and Substance P Mediate Emetic Response Induction by Masked Trichothecene Deoxynivalenol-3-Glucoside through Ca
Topics: Animals; Emetics; Glucose; Glucosides; Mink; Receptors, G-Protein-Coupled; Receptors, Gastrointestinal Hormone; Substance P; Trichothecenes; Vomiting | 2022 |
Elevated serum substance P level as a predictive marker for moderately emetogenic chemotherapy-induced nausea and vomiting: A prospective cohort study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Drug-Related Side Effects and Adverse Reactions; Emetics; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nausea; Neoplasms; Prognosis; Prospective Studies; Substance P; Survival Rate; Vomiting | 2021 |
[Substance P in antitumor drug-induced adverse reactions].
Topics: Animals; Antineoplastic Agents; Carboplatin; Histamine Antagonists; Humans; Nausea; Neuropeptides; Paclitaxel; Pyridines; Pyrimidinones; Substance P; Vomiting | 2013 |
Cyclophosphamide causes activation of protein kinase A (PKA) in the brainstem of vomiting least shrews (Cryptotis parva).
Topics: Animals; Brain Stem; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclophosphamide; Enzyme Activation; Female; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Receptors, Neurokinin-1; Receptors, Serotonin, 5-HT3; RNA, Messenger; Shrews; Substance P; Time Factors; Vomiting | 2014 |
Antiemetic role of thalidomide in a rat model of cisplatin-induced emesis.
Topics: Animals; Antiemetics; Antineoplastic Agents; Cisplatin; Disease Models, Animal; Eating; Kaolin; Male; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P; Thalidomide; Vomiting | 2014 |
Aprepitant for the management of refractory emesis in a patient with a small bowel carcinoid tumor.
Topics: Aged, 80 and over; Antiemetics; Aprepitant; Carcinoid Tumor; Female; Humans; Intestinal Neoplasms; Morpholines; Nausea; Neurokinin-1 Receptor Antagonists; Serotonin; Serotonin 5-HT3 Receptor Antagonists; Substance P; Treatment Outcome; Vomiting | 2014 |
Chemotherapy-Induced Nausea and Vomiting.
Topics: Drug Therapy; Humans; Nausea; Receptors, Neurokinin-1; Serotonin 5-HT3 Receptor Antagonists; Substance P; Vomiting | 2015 |
Thapsigargin-induced activation of Ca(2+)-CaMKII-ERK in brainstem contributes to substance P release and induction of emesis in the least shrew.
Topics: Animals; Brain Stem; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Female; Male; MAP Kinase Signaling System; Phosphorylation; Receptors, Neurokinin-1; Shrews; Substance P; Thapsigargin; Vomiting | 2016 |
Discovery of a novel, potent and orally active series of gamma-lactams as selective NK1 antagonists.
Topics: Administration, Oral; Chemistry, Pharmaceutical; Drug Design; Humans; Lactams; Models, Chemical; Molecular Structure; Neurokinin-1 Receptor Antagonists; Nitrogen; Protein Binding; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P; Urea; Vomiting | 2008 |
Delta 9-tetrahydrocannabinol suppresses vomiting behavior and Fos expression in both acute and delayed phases of cisplatin-induced emesis in the least shrew.
Topics: Analgesics, Non-Narcotic; Animals; Area Postrema; Brain Stem; Cisplatin; Dronabinol; Drug Therapy, Combination; Female; Immunohistochemistry; Injections, Intraperitoneal; Microscopy, Confocal; Neurons; Oncogene Proteins v-fos; Piperidines; Presynaptic Terminals; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Serotonin; Shrews; Solitary Nucleus; Substance P; Time Factors; Vomiting | 2009 |
A re-evaluation of the neurotransmitter basis of chemotherapy-induced immediate and delayed vomiting: evidence from the least shrew.
Topics: Animals; Antineoplastic Agents; Brain; Brain Stem; Chromatography, High Pressure Liquid; Cisplatin; Dopamine; Dose-Response Relationship, Drug; Duodenum; Emetics; Female; Frontal Lobe; Homovanillic Acid; Jejunum; Male; Neurotransmitter Agents; Serotonin; Shrews; Substance P; Vomiting | 2009 |
Gingerol inhibits cisplatin-induced vomiting by down regulating 5-hydroxytryptamine, dopamine and substance P expression in minks.
Topics: Animals; Antiemetics; Area Postrema; Catechols; Cisplatin; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Down-Regulation; Fatty Alcohols; Ileum; Intestinal Mucosa; Male; Mink; Serotonin; Substance P; Vomiting | 2009 |
Ablation of least shrew central neurokinin NK1 receptors reduces GR73632-induced vomiting.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Stem; Dose-Response Relationship, Drug; Female; Immunohistochemistry; Injections, Intraperitoneal; Injections, Intraventricular; Intestine, Small; Myenteric Plexus; Peptide Fragments; Photomicrography; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Shrews; Substance P; Vomiting | 2009 |
Receptor-selective agonists induce emesis and Fos expression in the brain and enteric nervous system of the least shrew (Cryptotis parva).
Topics: Adaptation, Psychological; Animals; Brain; Brain Stem; Emetics; Enteric Nervous System; Female; Injections, Intraperitoneal; Neurons; Perfusion; Proto-Oncogene Proteins c-fos; Serotonin; Shrews; Solitary Nucleus; Substance P; Time Factors; Vagus Nerve; Vomiting | 2009 |
Differential temporal changes in brain and gut substance P mRNA expression throughout the time-course of cisplatin-induced vomiting in the least shrew (Cryptotis parva).
Topics: Animals; Antineoplastic Agents; Brain; Cisplatin; Disease Models, Animal; Gastrointestinal Tract; Gene Expression Regulation; Humans; Mice; Phylogeny; Protein Precursors; Rats; RNA, Messenger; Sequence Analysis, Protein; Shrews; Statistics as Topic; Substance P; Tachykinins; Time Factors; Vomiting | 2010 |
Effect of gingerol on substance P and NK1 receptor expression in a vomiting model of mink.
Topics: Animals; Area Postrema; Blotting, Western; Catechols; Disease Models, Animal; Fatty Alcohols; Ileum; Immunohistochemistry; Male; Mink; Receptors, Neurokinin-1; Substance P; Vomiting | 2010 |
The antiemetic 5-HT3 receptor antagonist Palonosetron inhibits substance P-mediated responses in vitro and in vivo.
Topics: Action Potentials; Animals; Antiemetics; Antineoplastic Agents; Calcium; Cell Line; Cisplatin; Disease Models, Animal; Dose-Response Relationship, Drug; Isoquinolines; Male; Neurokinin-1 Receptor Antagonists; Neurons; Nodose Ganglion; Palonosetron; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin 5-HT3 Receptor Antagonists; Substance P; Vomiting | 2010 |
Synergistic antiemetic interactions between serotonergic 5-HT3 and tachykininergic NK1-receptor antagonists in the least shrew (Cryptotis parva).
Topics: Analysis of Variance; Animals; Antiemetics; Dose-Response Relationship, Drug; Drug Synergism; Female; Indoles; Male; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Serotonin; Serotonin 5-HT3 Receptor Antagonists; Shrews; Substance P; Tropisetron; Vomiting | 2011 |
Identification of a novel marker associated with risk for delayed chemotherapy-induced vomiting.
Topics: Adult; Aged; Antiemetics; Antineoplastic Agents; Biomarkers; Case-Control Studies; Creatinine; Dexamethasone; Drug Therapy, Combination; Female; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Neoplasms; Predictive Value of Tests; Serotonin 5-HT3 Receptor Antagonists; Severity of Illness Index; Substance P; Time Factors; Vomiting | 2012 |
Cisplatin causes over-expression of tachykinin NK(1) receptors and increases ERK1/2- and PKA- phosphorylation during peak immediate- and delayed-phase emesis in the least shrew (Cryptotis parva) brainstem.
Topics: Animals; Brain Stem; Cisplatin; Cyclic AMP-Dependent Protein Kinases; Female; Gene Expression Regulation; Humans; Intestinal Mucosa; Intestines; Male; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein Kinases; Rats; Receptors, Neurokinin-1; Receptors, Serotonin; RNA, Messenger; Shrews; Signal Transduction; Substance P; Vomiting | 2013 |
Antiemetic effect of a tachykinin NK1 receptor antagonist GR205171 on cisplatin-induced early and delayed emesis in the pigeon.
Topics: Animals; Antiemetics; Cisplatin; Columbidae; Female; Immunohistochemistry; Injections, Intramuscular; Injections, Intravenous; Injections, Intraventricular; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Solitary Nucleus; Substance P; Tetrazoles; Vagus Nerve; Vomiting | 2003 |
The ups and downs of novel antiemetic drugs, part 1: substance P, 5-HT, and the neuropharmacology of vomiting.
Topics: Antiemetics; Antineoplastic Agents; Aprepitant; Area Postrema; Brain Stem; Depressive Disorder; Humans; Morpholines; Receptors, Neurokinin-1; Serotonin; Solitary Nucleus; Stress Disorders, Traumatic; Substance P; Vomiting | 2003 |
The ups and downs of novel antiemetic drugs, part 2: an illustration.
Topics: Antiemetics; Brain Stem; Depressive Disorder; Humans; Models, Neurological; Neurokinin-1 Receptor Antagonists; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin; Stress Disorders, Traumatic; Substance P; Vomiting | 2003 |
The role of biopharmaceutics in the development of a clinical nanoparticle formulation of MK-0869: a Beagle dog model predicts improved bioavailability and diminished food effect on absorption in human.
Topics: Absorption; Administration, Oral; Animals; Antineoplastic Agents; Aprepitant; Area Under Curve; Biological Availability; Capsules; Chemistry, Pharmaceutical; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Dogs; Drug Administration Schedule; Drug Evaluation, Preclinical; Fasting; Food-Drug Interactions; Humans; Male; Models, Animal; Morpholines; Nanostructures; Nausea; Substance P; Tablets; Technology, Pharmaceutical; Upper Gastrointestinal Tract; Vomiting | 2004 |
Re: 5-Hydroxyindoleacetic acid and substance P profiles in patients receiving emetogenic chemotherapy.
Topics: Antiemetics; Antineoplastic Agents; Humans; Hydroxyindoleacetic Acid; Nausea; Serotonin 5-HT3 Receptor Antagonists; Serotonin Antagonists; Substance P; Time Factors; Vomiting; Vomiting, Anticipatory | 2007 |
Pharmacological characterization of T-2328, 2-fluoro-4'-methoxy-3'-[[[(2S,3S)-2-phenyl-3-piperidinyl]amino]methyl]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride, as a brain-penetrating antagonist of tachykinin NK1 receptor.
Topics: Animals; Antiemetics; Antineoplastic Agents; Aprepitant; Binding Sites; Brain; Cell Line, Tumor; CHO Cells; Cisplatin; Cricetinae; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Ferrets; Gerbillinae; Humans; Kinetics; Male; Morpholines; Motor Activity; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Substance P; Transfection; Vomiting | 2008 |
Utilization of the least shrew as a rapid and selective screening model for the antiemetic potential and brain penetration of substance P and NK1 receptor antagonists.
Topics: Animals; Antiemetics; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enteric Nervous System; Neurokinin-1 Receptor Antagonists; Oncogene Proteins v-fos; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Recombinant Fusion Proteins; Ribosome Inactivating Proteins, Type 1; Saporins; Shrews; Stereotyped Behavior; Substance P; Time Factors; Tissue Distribution; Vomiting | 2008 |
Anti-emetic profile of a non-peptide neurokinin NK1 receptor antagonist, CP-99,994, in ferrets.
Topics: Animals; Ferrets; Male; Neurokinin A; Piperidines; Stereoisomerism; Substance P; Vomiting | 1993 |
Enantiospecific inhibition of emesis induced by nicotine in the house musk shrew (Suncus murinus) by the neurokinin1 (NK1) receptor antagonist CP-99,994.
Topics: Animals; Antiemetics; Dose-Response Relationship, Drug; Indoles; Isoindoles; Male; Morphine; Neurokinin A; Nicotine; Piperidines; Receptors, Neurokinin-1; Shrews; Stereoisomerism; Substance P; Vomiting | 1995 |
The tachykinin NK1 receptor antagonist PD 154075 blocks cisplatin-induced delayed emesis in the ferret.
Topics: Animals; Antiemetics; Antineoplastic Agents; Behavior, Animal; Brain; CHO Cells; Cisplatin; Cricetinae; Dogs; Female; Ferrets; Gerbillinae; Guinea Pigs; Humans; Male; Mice; Neurokinin-1 Receptor Antagonists; Rats; Rats, Wistar; Sensitivity and Specificity; Sheep; Substance P; Swine; Time Factors; Tryptophan; Vomiting | 1997 |
The effect of CP-99994 on the responses to provocative motion in the cat.
Topics: Animals; Antiemetics; Area Under Curve; Binding, Competitive; Cats; Half-Life; Injections, Subcutaneous; Motion Sickness; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Substance P; Vomiting | 1997 |
Fighting nausea in the '90s: more and better anti-emetics can help.
Topics: Antiemetics; Antineoplastic Agents; Dexamethasone; Drug Synergism; Drug Therapy, Combination; Granisetron; Humans; Isonipecotic Acids; Nausea; Ondansetron; Serotonin Antagonists; Substance P; Vomiting | 1997 |
Anti-emetic effects of a novel NK-1 receptor antagonist HSP-117 in ferrets.
Topics: Animals; Antiemetics; Benzofurans; Brain Stem; Cerebral Ventricles; Copper Sulfate; Emetics; Ferrets; In Vitro Techniques; Injections, Intraventricular; Male; Membrane Potentials; Morphine; Neurokinin-1 Receptor Antagonists; Piperidines; Substance P; Vomiting | 1998 |
Neurokinin antagonism and chemotherapy-induced emesis.
Topics: Acetals; Antiemetics; Antineoplastic Agents; Aprepitant; Cisplatin; Dexamethasone; Female; Granisetron; Humans; Male; Morpholines; Multicenter Studies as Topic; Nausea; Neurokinin-1 Receptor Antagonists; Randomized Controlled Trials as Topic; Substance P; Vomiting | 1999 |
MK 869. L 754030, MK 0869.
Topics: Antiemetics; Antineoplastic Agents; Aprepitant; Clinical Trials, Phase II as Topic; Humans; Morpholines; Neurokinin-1 Receptor Antagonists; Placebos; Randomized Controlled Trials as Topic; Substance P; Vomiting | 1999 |
The role of tachykinin NK-1 receptors in the area postrema of ferrets in emesis.
Topics: Animals; Antiemetics; Antineoplastic Agents; Benzofurans; Chemoreceptor Cells; Cisplatin; Copper Sulfate; Drug Interactions; Ferrets; Fourth Ventricle; Male; Medulla Oblongata; Morphine; Narcotics; Neurokinin-1 Receptor Antagonists; Neurons; Piperidines; Proto-Oncogene Proteins c-fos; Radioligand Assay; Receptors, Neurokinin-1; Solitary Nucleus; Substance P; Tachykinins; Tritium; Vomiting | 2000 |
The development of the emetic reflex in the house musk shrew, Suncus murinus.
Topics: Age Factors; Animals; Body Weight; Diterpenes; Female; Male; Motion Sickness; Neurotoxins; Pyrogallol; Reflex; Shrews; Solitary Nucleus; Substance P; Vagus Nerve; Vestibule, Labyrinth; Vomiting | 2000 |
Localization of phosphodiesterase-4 isoforms in the medulla and nodose ganglion of the squirrel monkey.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Base Sequence; Blotting, Western; Cyclic Nucleotide Phosphodiesterases, Type 4; Female; Immunohistochemistry; In Situ Hybridization; Isoenzymes; Male; Medulla Oblongata; Microscopy, Fluorescence; Molecular Sequence Data; Nodose Ganglion; Reflex; RNA Probes; Saimiri; Substance P; Vomiting | 2001 |
Assessing the emetic potential of PDE4 inhibitors in rats.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Male; Pentobarbital; Phosphodiesterase Inhibitors; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Neurokinin-3; Substance P; Vomiting | 2002 |
The distribution of substance P, enkephalin, and serotonin immunoreactivities in the area postrema of the rat and cat.
Topics: Animals; Brain Stem; Cats; Enkephalins; Immunoenzyme Techniques; Male; Neurosecretory Systems; Rats; Rats, Inbred Strains; Reflex; Serotonin; Species Specificity; Substance P; Vomiting | 1985 |