substance p has been researched along with Nerve Pain in 69 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (5.80) | 18.7374 |
| 1990's | 6 (8.70) | 18.2507 |
| 2000's | 20 (28.99) | 29.6817 |
| 2010's | 30 (43.48) | 24.3611 |
| 2020's | 9 (13.04) | 2.80 |
| Authors | Studies |
|---|---|
| Bennett, DLH; Finnerup, NB; Gylfadottir, SS; Itani, M; Jensen, TS; Karlsson, P; Kristensen, AG; Nyengaard, JR; Sindrup, SH; Tankisi, H | 1 |
| Feng, S; Mao, M; Wang, J; Wang, X; Zhang, S; Zhou, F | 1 |
| Abe, K; Chiba, T; Kambe, T; Kawakami, K; Taguchi, K; Yamamoto, K | 1 |
| Luo, F; Niu, SN; Wang, JA | 1 |
| Fukushige, R; Hisaoka-Nakashima, K; Kishida, Y; Morioka, N; Nakamura, Y; Nakata, Y; Watanabe, K | 1 |
| Guo, N; Hallberg, M; Nyberg, F; Nyman, J; Sandström, A; Yu, L | 1 |
| Ahmad, N; Al-Harrasi, A; Ali, G; Halim, SA; Khan, A; Khan, J; Naveed, M; Subhan, F; Ullah, R | 1 |
| Chuinsiri, N; Durham, J; Edwards, D; Nile, CJ; Telezhkin, V; Van der Cruyssen, F | 1 |
| Fransson, R; Gaugaz, FZ; Hallberg, M; Lesniak, A; Lindeberg, G; Nyberg, F; Sandström, A; Skogh, A; Svensson, R | 2 |
| Kaneko, C; Kawai, K; Sugawara, Y; Suzuki, S; Tanimura, R; Tsuji, R; Yagi, M; Yuzawa, N | 1 |
| Chacur, M; Martins, DO; Rocha, IRC; Santos, FM; Silva, JT | 1 |
| Hallberg, M; Sandstrom, A | 1 |
| Duan, Z; Li, J; Pang, X; Su, Z; Wang, H | 1 |
| Li, SH; Liang, ZH; Lin, GH; Liu, XH; Pei, WY; Xu, QN; Yang, JJ; Yang, L; Zhang, Y | 1 |
| Chen, J; Wang, R; Wu, Y | 1 |
| Dong, X; Gour, N; Green, DP; Limjunyawong, N; Pundir, P | 1 |
| Chai, CY; Chang, CH; Huang, SH; Lee, SS; Lin, CH; Lo, JJ; Wu, CS; Wu, SH; Wu, ZS | 1 |
| Badolato, M; Brizzi, A; Caroleo, MC; Carullo, G; Cione, E; De Rosa, M; Gallelli, L; Pandey, A | 1 |
| Cheng, HT; Dauch, JR; Feldman, EL; Hsieh, W; Porzio, MT; Singleton, JR; Smith, AG; Yanik, BM | 1 |
| Anderson, EM; Bokrand-Donatelli, Y; Caudle, RM; Mustafa, G; Neubert, JK | 1 |
| Ding, X; Fan, X; Ning, L; Wang, C; Wang, J; Wang, Y; Yue, S; Zhang, Y | 1 |
| Bäckryd, E; Gerdle, B; Ghafouri, B; Larsson, B | 1 |
| Shehab, SA | 1 |
| Chen, W; Ennes, HS; Kim, H; Marvizón, JC; McRoberts, JA; Walwyn, W | 1 |
| Hsieh, YL; Hu, ME; Ko, MH; Lan, CT; Tseng, TJ | 1 |
| Ganev, EG; Hiruma-Lima, CA; Martins, DF; Mazzardo-Martins, L; Nishijima, CM; Rocha, LR; Santos, AR | 1 |
| Chen, YW; Huang, PC; Hung, CH; Shao, DZ; Tzeng, JI; Wang, JJ | 1 |
| Al Nimer, F; Carlström, KE; Dominguez, CA; Lindblom, RP; Ortlieb Guerreiro-Cacais, A; Piehl, F; Zhang, XM | 1 |
| Liu, YJ; Song, GH; Zhang, C | 1 |
| Chen, K; Liao, MF; Wang, J; Wang, XR; Yao, WL; Zhang, ZF | 1 |
| Brolin, E; Fransson, R; Hallberg, M; Haramaki, Y; Jonsson, A; Nordvall, G; Nyberg, F; Sandström, A; Skogh, A; Watanabe, H | 1 |
| Gautam, M; Kaler, S; Kumar, R; Prasoon, P; Ray, SB; Reeta, KH | 1 |
| Choi, JH; Chung, JY; Hwang, IK; Im, W; Kang, JY; Kim, M; Kim, SH; Lee, KY; Yoo, DY; Youn, HY | 1 |
| Amin, M; Amin, S; Barbe, MF; Barr, AE; Clark, BD; Elliott, MB | 1 |
| Adler, JE; Skoff, AM; Zhao, C | 1 |
| Chikuma, T; Kato, T; Muramatsu, M; Takeda, K | 1 |
| Brain, SD; Fernandes, ES; Schmidhuber, SM | 1 |
| Akasaka, Y; Hatta, A; Inoue, H; Sakai, A; Suzuki, H; Takasu, K; Tsukahara, M | 1 |
| Muto, Y; Sakai, A; Sakamoto, A; Suzuki, H | 1 |
| Chichorro, JG; Martini, AC; Rae, GA; Teodoro, FC; Tronco Júnior, MF; Zampronio, AR | 1 |
| Baas, M; Duraku, LS; Holstege, JC; Hossaini, M; Ruigrok, TJ; Schüttenhelm, BN; Walbeehm, ET | 1 |
| De Risio, L; Gandini, G; Goedde, T; Matiasek, K; Reese, S; Rosati, M; Steffen, F | 1 |
| McKenzie, RC; Norval, M; Sysa-Jedrzejowska, A; Zak-Prelich, M | 1 |
| Calcutt, NA; Campana, WM; Catalano, R; Feng, Y; Freshwater, JD; Marsala, M; Protter, AA; Scott, B; Svensson, CI; Westerlund, A; Yaksh, TL | 1 |
| Hofstädter, F; Lerch, K; Schubert, TE; Straub, RH; Weidler, C | 1 |
| Hong, JS; Schwasinger, ET; Tseng, LF; Wu, HE | 1 |
| Kreider, RA; Rothman, SM; Winkelstein, BA | 1 |
| Clapp, DW; Hingtgen, CM; Roy, SL | 1 |
| Akada, Y; Amano, K; Fukudome, Y; Itoh, M; Ogawa, S; Yamamoto, I; Yamasaki, F | 1 |
| Chun, J; Inoue, M; Kawakami, M; Ueda, H; Yamaguchi, A | 1 |
| Kim, JH; Lee, SE | 1 |
| Altier, C; Castiglioni, AJ; Chapman, K; Dale, CS; Dickenson, AH; Evans, RM; Kisilevsky, AE; Lipscombe, D; Matthews, EA; Vergnolle, N; Zamponi, GW | 1 |
| Li, G; Liang, S; Wan, F; Wang, Y; Xu, C; Zhang, A; Zhang, C; Zhu, G | 1 |
| Blömer, U; Held-Feindt, J; Juraschek, M; Knerlich-Lukoschus, F; Lucius, R; Mehdorn, HM | 1 |
| Leo, A; Marano, E; Steardo, L | 1 |
| Brown, SI; Feldman, ST; Frucht-Pery, J | 1 |
| Ishii, S; Usui, M; Yamashita, T | 1 |
| Iwamoto, T; Kohri, H; Noguchi, K; Ohara, M; Sato, S; Senba, E; Yasuda, T | 1 |
| Arsenault, K; Helgren, ME; Kapadia, SE; LaMotte, CC; Wolfe, M | 1 |
| Allen, BJ; Finke, MP; Ghilardi, JR; Honore, P; Lappi, DA; Li, J; Luger, NM; Mantyh, PW; Nichols, ML; Rogers, SD; Simone, DA | 1 |
| Herrero, JF; Laird, JM; López-García, JA | 1 |
| Abdulla, FA; Smith, PA; Stebbing, MJ | 1 |
| Cheng, C; Hargreaves, K; Miampamba, M; Sharkey, KA; Zochodne, DW | 1 |
| Kastin, AJ; Martin-Schild, S; Smith, RR; Zadina, JE | 1 |
| Endoh, H; Fujiwara, N; Fukuda, S; Kumagai, Y; Shimoji, K | 1 |
| Bernstein, JE | 2 |
| Hawk, RJ; Millikan, LE | 1 |
5 review(s) available for substance p and Nerve Pain
| Article | Year |
|---|---|
Exploring the roles of neuropeptides in trigeminal neuropathic pain: A systematic review and narrative synthesis of animal studies.
Topics: Animals; Calcitonin Gene-Related Peptide; Neuralgia; Substance P; Trigeminal Neuralgia | 2021 |
From the Anti-Nociceptive Substance P Metabolite Substance P (1-7) to Small Peptidomimetics.
Topics: Analgesics; Animals; Binding Sites; Dipeptides; Humans; Hyperalgesia; Neuralgia; Oligopeptides; Peptide Fragments; Peptidomimetics; Protein Conformation; Structure-Activity Relationship; Substance P | 2018 |
Sensory-nerve-derived neuropeptides: possible therapeutic targets.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Calcitonin Gene-Related Peptide; Galanin; Humans; Inflammation; Inflammation Mediators; Neuralgia; Neuropeptides; Receptors, G-Protein-Coupled; Sensory Receptor Cells; Signal Transduction; Substance P; Tachykinins | 2009 |
Wind-up of spinal cord neurones and pain sensation: much ado about something?
Topics: Afferent Pathways; Analgesics; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cats; Humans; Hyperalgesia; Inflammation; Ion Transport; Models, Neurological; Morphine; Nerve Fibers; Nerve Tissue Proteins; Neuralgia; Neuronal Plasticity; Neurons, Afferent; Neuropeptides; Nociceptors; Pain; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Reflex; Spinal Cord; Substance P; Synaptic Transmission; Viscera | 2000 |
Capsaicin in dermatologic disease.
Topics: Capsaicin; Humans; Middle Aged; Neuralgia; Pruritus; Skin Diseases; Substance P | 1988 |
2 trial(s) available for substance p and Nerve Pain
| Article | Year |
|---|---|
[Shallow Fire-needle Acupuncture Stimulation Plus Cupping Relieves Neuralgia and Down-regulates Serum Substance P Level in Patients with Acute Herpes Zoster].
Topics: Acupuncture Therapy; Herpes Zoster; Humans; Moxibustion; Neuralgia; Substance P; Treatment Outcome | 2018 |
Efficacy of baclofen in trigeminal neuralgia and some other painful conditions. A clinical trial.
Topics: Adult; Amputation Stumps; Baclofen; Carbamazepine; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Neuralgia; Phenytoin; Radiculopathy; Substance P; Tabes Dorsalis; Trigeminal Neuralgia | 1984 |
62 other study(ies) available for substance p and Nerve Pain
| Article | Year |
|---|---|
Analysis of Macrophages and Peptidergic Fibers in the Skin of Patients With Painful Diabetic Polyneuropathy.
Topics: Aged; Biomarkers; Biopsy; Calcitonin Gene-Related Peptide; Cross-Sectional Studies; Diabetic Neuropathies; Female; Humans; Macrophages; Male; Middle Aged; Nerve Fibers; Neuralgia; Skin; Substance P | 2022 |
Participation of transient receptor potential vanilloid 1 in the analgesic effect of duloxetine for paclitaxel induced peripheral neuropathic pain.
Topics: Analgesics; Animals; Antineoplastic Agents; Calcitonin Gene-Related Peptide; Duloxetine Hydrochloride; Ganglia, Spinal; Hyperalgesia; Neuralgia; Paclitaxel; Pain; Peripheral Nervous System Diseases; Rats; Spinal Cord Dorsal Horn; Substance P; TRPV Cation Channels; Tumor Necrosis Factor-alpha | 2022 |
Vincristine increased spinal cord substance P levels in a peripheral neuropathy rat model.
Topics: Animals; Disease Models, Animal; Humans; Neuralgia; Quality of Life; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Vincristine | 2022 |
Pulsed radiofrequency alleviated neuropathic pain by down-regulating the expression of substance P in chronic constriction injury rat model.
Topics: Animals; Constriction, Pathologic; Disease Models, Animal; Hyperalgesia; Male; Neuralgia; Pulsed Radiofrequency Treatment; Rats; Rats, Sprague-Dawley; Substance P | 2020 |
Continuous infusion of substance P into rat striatum relieves mechanical hypersensitivity caused by a partial sciatic nerve ligation via activation of striatal muscarinic receptors.
Topics: Animals; Chronic Pain; Corpus Striatum; Hyperalgesia; Male; Neuralgia; Nociception; Pain Measurement; Peripheral Nerve Injuries; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Neurokinin-1; Sciatic Nerve; Sciatic Neuropathy; Substance P | 2020 |
The amino-terminal heptapeptide of the algesic substance P provides analgesic effect in relieving chronic neuropathic pain.
Topics: Amides; Analgesics; Analgesics, Opioid; Animals; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Mice, Inbred ICR; Neuralgia; Pain Threshold; Peptide Fragments; Receptors, Opioid, mu; Substance P | 2021 |
Attenuation of nociceptive and paclitaxel-induced neuropathic pain by targeting inflammatory, CGRP and substance P signaling using 3-Hydroxyflavone.
Topics: Animals; Antineoplastic Agents, Phytogenic; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Drug Delivery Systems; Flavonoids; Inflammation Mediators; Male; Mice; Neuralgia; Nociception; Paclitaxel; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Substance P | 2021 |
Importance of N- and C-terminal residues of substance P 1-7 for alleviating allodynia in mice after peripheral administration.
Topics: Analgesics; Animals; Caco-2 Cells; Humans; Hyperalgesia; Male; Mice; Neuralgia; Peptide Fragments; Permeability; Protein Stability; Sciatic Nerve; Structure-Activity Relationship; Substance P | 2017 |
Discovery of highly selective κ-opioid receptor agonists: 10α-Hydroxy TRK-820 derivatives.
Topics: Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Discovery; Humans; Mice; Molecular Structure; Morphinans; Neuralgia; Rats; Receptors, Opioid, kappa; Spiro Compounds; Structure-Activity Relationship; Substance P | 2017 |
Impact of N-methylation of the substance P 1-7 amide on anti-allodynic effect in mice after peripheral administration.
Topics: Analgesics; Animals; Caco-2 Cells; Humans; Hyperalgesia; Intestinal Absorption; Male; Methylation; Mice; Neuralgia; Peptide Fragments; Substance P | 2017 |
Non-pharmacological treatment affects neuropeptide expression in neuropathic pain model.
Topics: Animals; Disease Models, Animal; Ganglia, Spinal; Gene Expression Regulation; Male; Muscle Strength; Musculoskeletal Manipulations; Nerve Tissue Proteins; Neuralgia; Neurons; Neuropeptides; Rats; Rats, Wistar; Receptors, Opioid; Substance P; TRPV Cation Channels | 2018 |
Blocking Mammalian Target of Rapamycin (mTOR) Alleviates Neuropathic Pain Induced by Chemotherapeutic Bortezomib.
Topics: Animals; Behavior, Animal; Bortezomib; Calcitonin Gene-Related Peptide; Carrier Proteins; Chromones; Disease Models, Animal; Intracellular Signaling Peptides and Proteins; Male; Morpholines; Neuralgia; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Spinal Cord; Substance P; TOR Serine-Threonine Kinases; Up-Regulation | 2018 |
Puerarin suppresses TRPV1, calcitonin gene-related peptide and substance P to prevent paclitaxel-induced peripheral neuropathic pain in rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Calcitonin Gene-Related Peptide; Isoflavones; Male; Neuralgia; Paclitaxel; Rats; Rats, Sprague-Dawley; Substance P; TRPV Cation Channels | 2019 |
A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain.
Topics: Animals; Cell Line; Cytokines; Female; Humans; Male; Mast Cells; Mice; Mice, Inbred C57BL; Neuralgia; Receptors, G-Protein-Coupled; Receptors, Neurokinin-1; Substance P | 2019 |
Dose-Dependent Effect of Hyperbaric Oxygen Treatment on Burn-Induced Neuropathic Pain in Rats.
Topics: Animals; Astrocytes; Behavior, Animal; Brain-Derived Neurotrophic Factor; Burns; Calcitonin Gene-Related Peptide; Glial Fibrillary Acidic Protein; Hyperbaric Oxygenation; Male; Medulla Oblongata; Neuralgia; Nociception; Rats, Sprague-Dawley; Receptors, Melatonin; Receptors, Opioid; Skin; Spinal Cord Dorsal Horn; Substance P | 2019 |
Targeting Neuropathic Pain: Pathobiology, Current Treatment and Peptidomimetics as a New Therapeutic Opportunity.
Topics: Animals; Anticonvulsants; Hyperalgesia; Mice; Neuralgia; Peptidomimetics; Rats; Substance P | 2020 |
Increased axonal regeneration and swellings in intraepidermal nerve fibers characterize painful phenotypes of diabetic neuropathy.
Topics: Aged; Axons; Diabetic Neuropathies; Epidermis; Female; GAP-43 Protein; Humans; Male; Middle Aged; Nerve Degeneration; Nerve Fibers; Neuralgia; Pain Measurement; Receptor, trkA; Substance P; TRPV Cation Channels | 2013 |
Anti-nociceptive effect of a conjugate of substance P and light chain of botulinum neurotoxin type A.
Topics: Analgesics; Animals; Antineoplastic Agents, Phytogenic; Botulinum Toxins, Type A; Cells, Cultured; Conditioning, Operant; Facial Pain; Female; Hot Temperature; Immunohistochemistry; Male; Mice; Mice, Hairless; Neuralgia; Neurons; Paclitaxel; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Reward; Substance P; Synaptosomal-Associated Protein 25 | 2013 |
Role of colchicine-induced microtubule depolymerization in hyperalgesia via TRPV4 in rats with chronic compression of the dorsal root ganglion.
Topics: Animals; Calcium; Cell Survival; Colchicine; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Male; Microtubules; Nerve Compression Syndromes; Neuralgia; Radiculopathy; Random Allocation; Rats; Rats, Wistar; Substance P; Touch; TRPV Cation Channels; Tubulin Modulators | 2014 |
Do low levels of beta-endorphin in the cerebrospinal fluid indicate defective top-down inhibition in patients with chronic neuropathic pain? A cross-sectional, comparative study.
Topics: Adult; Analgesics; beta-Endorphin; Biomarkers; Chronic Pain; Clinical Trials as Topic; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Neuralgia; Pain, Intractable; Pain, Postoperative; Substance P | 2014 |
Fifth lumbar spinal nerve injury causes neurochemical changes in corresponding as well as adjacent spinal segments: a possible mechanism underlying neuropathic pain.
Topics: Animals; Lumbar Vertebrae; Neuralgia; Neuropeptide Y; Peripheral Nerve Injuries; Rats; Rats, Wistar; Receptors, Neurokinin-1; Spinal Cord; Spinal Nerves; Substance P; Up-Regulation | 2014 |
BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals.
Topics: Animals; Brain-Derived Neurotrophic Factor; Ganglia, Spinal; Male; Mice; Mice, Inbred C57BL; Neuralgia; Neurons; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Signal Transduction; Substance P | 2014 |
Peptidergic intraepidermal nerve fibers in the skin contribute to the neuropathic pain in paclitaxel-induced peripheral neuropathy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Calcitonin Gene-Related Peptide; Epidermis; Male; Nerve Degeneration; Nerve Fibers; Neuralgia; Paclitaxel; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Substance P | 2014 |
Citral: a monoterpene with prophylactic and therapeutic anti-nociceptive effects in experimental models of acute and chronic pain.
Topics: Acute Pain; Acyclic Monoterpenes; Analgesics; Animals; Capsaicin; Chronic Pain; Excitatory Amino Acids; Formaldehyde; Glutamic Acid; Hyperalgesia; Ischemia; Ketanserin; Male; Mice; Monoterpenes; Neuralgia; Pain, Postoperative; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Serotonin 5-HT2 Receptor Antagonists; Stomach Ulcer; Substance P; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2014 |
Therapeutic ultrasound suppresses neuropathic pain and upregulation of substance P and neurokinin-1 receptor in rats after peripheral nerve injury.
Topics: Animals; Male; Neuralgia; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Sciatic Neuropathy; Substance P; Treatment Outcome; Ultrasonic Therapy; Up-Regulation | 2015 |
Variability in C-type lectin receptors regulates neuropathic pain-like behavior after peripheral nerve injury.
Topics: Animals; Cathepsins; Gene Expression Profiling; Gene Expression Regulation; Genetic Variation; Inflammation; Interleukin-1beta; Lectins, C-Type; Male; Models, Genetic; Multigene Family; Neuralgia; Neuropeptides; Peripheral Nerve Injuries; Phenotype; Rats; Receptors, Interleukin-8A; RNA, Messenger; Signal Transduction; Substance P | 2014 |
[Roles of substance P and transient receptor potential vanilloid 1 in neuralgia in rats with chronic nonbacterial prostatitis].
Topics: Animals; Lumbosacral Region; Male; Neuralgia; Pain; Prostate; Prostatitis; Rats; Rats, Wistar; Spinal Cord; Substance P; TRPV Cation Channels | 2015 |
Blocking PAR2 attenuates oxaliplatin-induced neuropathic pain via TRPV1 and releases of substance P and CGRP in superficial dorsal horn of spinal cord.
Topics: Animals; Calcitonin Gene-Related Peptide; Cryopyrin-Associated Periodic Syndromes; Disease Models, Animal; Male; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Rats; Rats, Wistar; Receptor, PAR-2; Signal Transduction; Spinal Cord Dorsal Horn; Substance P; Treatment Outcome; TRPV Cation Channels; Up-Regulation | 2015 |
Small constrained SP1-7 analogs bind to a unique site and promote anti-allodynic effects following systemic injection in mice.
Topics: Analgesics; Animals; Area Under Curve; Binding Sites; Disease Models, Animal; Hyperalgesia; Male; Mice; Neuralgia; Pain Measurement; Pain Threshold; Peptide Fragments; Protein Binding; Statistics, Nonparametric; Substance P; Time Factors | 2015 |
Role of neurokinin type 1 receptor in nociception at the periphery and the spinal level in the rat.
Topics: Animals; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Male; Morpholines; Neuralgia; Nociception; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P | 2016 |
SP, CGRP changes in pyridoxine induced neuropathic dogs with nerve growth factor gene therapy.
Topics: Animals; Calcitonin Gene-Related Peptide; Dogs; Ganglia, Spinal; Genetic Therapy; H-Reflex; Hyperalgesia; Nerve Growth Factor; Neuralgia; Neurons; Pain Measurement; Pyridoxine; Recombinant Proteins; Substance P | 2016 |
High force reaching task induces widespread inflammation, increased spinal cord neurochemicals and neuropathic pain.
Topics: Analysis of Variance; Animals; Bone and Bones; Cytokines; Disease Models, Animal; Ectodysplasins; Enzyme-Linked Immunosorbent Assay; Female; Inflammation; Macrophages; Movement; Musculoskeletal System; Neural Conduction; Neuralgia; Neurokinin A; Rats; Rats, Sprague-Dawley; Sensory Thresholds; Skin; Spinal Cord; Substance P; Time Factors; Upper Extremity | 2009 |
Interleukin-1alpha regulates substance P expression and release in adult sensory neurons.
Topics: Age Factors; Animals; Capsaicin; Cells, Cultured; Female; Ganglia, Spinal; Inflammation; Interleukin 1 Receptor Antagonist Protein; Interleukin-1alpha; Interleukin-1beta; Nerve Growth Factor; Neuralgia; Nociceptors; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Sensory System Agents; Substance P; Up-Regulation | 2009 |
Effect of memantine on the levels of neuropeptides and microglial cells in the brain regions of rats with neuropathic pain.
Topics: Analgesics; Animals; Brain; CD11 Antigens; Disease Models, Animal; Excitatory Amino Acid Antagonists; Hyperalgesia; Hypothalamus; Male; Memantine; Microglia; Neuralgia; Neuropeptides; Periaqueductal Gray; Peripheral Nervous System Diseases; Rats; Rats, Wistar; Sciatic Neuropathy; Somatostatin; Substance P | 2009 |
Suppressive effects of glycyrrhetinic acid derivatives on tachykinin receptor activation and hyperalgesia.
Topics: Analgesics; Animals; Calcium; Capsaicin; CHO Cells; Cricetinae; Disease Models, Animal; Formaldehyde; Glycyrrhetinic Acid; Hot Temperature; Humans; Hyperalgesia; Inflammation; Ligation; Male; Neuralgia; Neurokinin A; Neurokinin B; Pain; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Sciatic Nerve; Substance P | 2011 |
Activation of NK₁ receptors in the locus coeruleus induces analgesia through noradrenergic-mediated descending inhibition in a rat model of neuropathic pain.
Topics: Adrenergic Neurons; Analgesia; Androstanes; Animals; Behavior, Animal; Benzimidazoles; Disease Models, Animal; Immunohistochemistry; Locus Coeruleus; Male; Neural Inhibition; Neuralgia; Neurokinin-1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P | 2012 |
Peripheral substance P and neurokinin-1 receptors have a role in inflammatory and neuropathic orofacial pain models.
Topics: Animals; Behavior, Animal; Cold Temperature; Constriction, Pathologic; Facial Pain; Grooming; Hot Temperature; Hyperalgesia; Inflammation; Injections; Lip; Male; Neuralgia; Neurokinin-1 Receptor Antagonists; Pain Measurement; Physical Stimulation; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P; Tropanes | 2013 |
Re-innervation patterns by peptidergic Substance-P, non-peptidergic P2X3, and myelinated NF-200 nerve fibers in epidermis and dermis of rats with neuropathic pain.
Topics: Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Dermis; Disease Models, Animal; Epidermis; Hyperalgesia; Langerhans Cells; Male; Nerve Fibers, Myelinated; Neuralgia; Neurofilament Proteins; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Reaction Time; Receptors, Purinergic P2X3; Substance P; Time Factors; Ubiquitin Thiolesterase | 2013 |
Developmental changes in voltage-gated calcium channel α(2)δ-subunit expression in the canine dorsal root ganglion.
Topics: Animals; Biomarkers; Calcitonin Gene-Related Peptide; Calcium Channels, L-Type; Cell Size; Dog Diseases; Dogs; Forelimb; Ganglia, Spinal; Hindlimb; Immunoenzyme Techniques; Immunohistochemistry; Neuralgia; Neurons; Spinal Cord; Substance P | 2012 |
Local immune responses and systemic cytokine responses in zoster: relationship to the development of postherpetic neuralgia.
Topics: Adolescent; Adult; Age Factors; Aged; Antibodies, Viral; CD3 Complex; CD56 Antigen; Cytokines; Female; Follow-Up Studies; Herpes Zoster; Herpesvirus 3, Human; Humans; Male; Middle Aged; Neuralgia; Skin; Substance P; T-Lymphocyte Subsets | 2003 |
Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Formaldehyde; Hyperalgesia; Imidazoles; Inflammation; Injections, Spinal; Isoenzymes; Male; Microglia; Mitogen-Activated Protein Kinases; Neuralgia; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pain Threshold; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 2003 |
Achilles tendinosis is associated with sprouting of substance P positive nerve fibres.
Topics: Achilles Tendon; Case-Control Studies; Female; Granulation Tissue; Hemosiderosis; Humans; Immunohistochemistry; Male; Middle Aged; Nerve Fibers; Neuralgia; Neurons, Afferent; Rupture, Spontaneous; Substance P; Tendinopathy | 2005 |
Pretreatment with antiserum against dynorphin, substance P, or cholecystokinin enhances the morphine-produced anti-allodynia in the sciatic nerve ligated mice.
Topics: Analgesics, Opioid; Animals; Antibodies; Cholecystokinin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Dynorphins; Immune Sera; Injections, Spinal; Ligation; Male; Mice; Morphine; Neuralgia; Peripheral Nervous System Diseases; Sciatic Nerve; Sciatic Neuropathy; Substance P | 2005 |
Spinal neuropeptide responses in persistent and transient pain following cervical nerve root injury.
Topics: Acute Disease; Animals; Calcitonin Gene-Related Peptide; Cervical Vertebrae; Chronic Disease; Hyperalgesia; Immunohistochemistry; Male; Neck Pain; Neuralgia; Radiculopathy; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Nerve Roots; Substance P | 2005 |
Stimulus-evoked release of neuropeptides is enhanced in sensory neurons from mice with a heterozygous mutation of the Nf1 gene.
Topics: Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Ganglia, Spinal; Heterozygote; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Growth Factor; Neuralgia; Neurofibromatosis 1; Neurons, Afferent; Neuropeptides; Organ Culture Techniques; Pain Threshold; Posterior Horn Cells; Presynaptic Terminals; Proto-Oncogene Proteins p21(ras); Substance P; Synaptic Transmission | 2006 |
Potent analgesic effects of a putative sodium channel blocker M58373 on formalin-induced and neuropathic pain in rats.
Topics: Analgesics; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Formaldehyde; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Male; Mexiletine; Motor Activity; Neuralgia; Nitriles; Pain; Pain Measurement; Piperidines; Rats; Rats, Wistar; Sodium Channel Blockers; Stress, Mechanical; Substance P; Veratridine | 2006 |
Loss of spinal substance P pain transmission under the condition of LPA1 receptor-mediated neuropathic pain.
Topics: Animals; Botulinum Toxins; Immunohistochemistry; Injections, Spinal; Lysophospholipids; Male; Mice; Mice, Knockout; Nerve Fibers, Unmyelinated; Neuralgia; Peripheral Nervous System; Posterior Horn Cells; Receptors, Lysophosphatidic Acid; rhoA GTP-Binding Protein; Sciatic Nerve; Spinal Cord; Substance P | 2006 |
Involvement of substance P and calcitonin gene-related peptide in development and maintenance of neuropathic pain from spinal nerve injury model of rat.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Disease Models, Animal; Dose-Response Relationship, Drug; Lidocaine; Male; Neuralgia; Pain Measurement; Peptide Fragments; Quinuclidines; Rats; Rats, Sprague-Dawley; Spinal Nerves; Substance P; Time Factors | 2007 |
Differential role of N-type calcium channel splice isoforms in pain.
Topics: Alternative Splicing; Analysis of Variance; Animals; Animals, Newborn; Calcium Channels, N-Type; Cells, Cultured; Disease Models, Animal; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Ganglia, Spinal; Hyperalgesia; Membrane Potentials; Neuralgia; Neurons, Afferent; Pain Measurement; Pain Threshold; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Substance P | 2007 |
Myocardial ischemic nociceptive signaling mediated by P2X3 receptor in rat stellate ganglion neurons.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Dinoprostone; Drug Interactions; Electric Stimulation; Female; Gene Expression Regulation; Male; Membrane Potentials; Myocardial Ischemia; Neuralgia; Neurons; Patch-Clamp Techniques; Phenols; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Signal Transduction; Stellate Ganglion; Substance P | 2008 |
Force-dependent development of neuropathic central pain and time-related CCL2/CCR2 expression after graded spinal cord contusion injuries of the rat.
Topics: Animals; Calcitonin Gene-Related Peptide; Chemokine CCL2; Gene Expression; Hyperalgesia; Immunohistochemistry; Inflammation; Lumbosacral Region; Male; Motor Activity; Neuralgia; Pain Measurement; Rats; Rats, Inbred LEC; Receptors, CCR2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord Injuries; Substance P; Thoracic Vertebrae; Time; TRPV Cation Channels | 2008 |
The use of capsaicin in herpes zoster ophthalmicus neuralgia.
Topics: Administration, Topical; Aged; Capsaicin; Female; Follow-Up Studies; Herpes Zoster Ophthalmicus; Humans; Male; Middle Aged; Neuralgia; Ointments; Substance P | 1997 |
Pain relief after nerve resection for post-traumatic neuralgia.
Topics: Adult; Female; Follow-Up Studies; Humans; Male; Median Nerve; Middle Aged; Nerve Degeneration; Neuralgia; Nociceptors; Pain; Paresthesia; Patient Satisfaction; Peripheral Nerve Injuries; Peripheral Nerves; Radial Nerve; Recurrence; Sensation Disorders; Substance P; Synaptic Transmission; Treatment Outcome; Ulnar Nerve | 1998 |
The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia.
Topics: Amitriptyline; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antidepressive Agents, Tricyclic; Clonazepam; Dinoprostone; Disease Models, Animal; Hyperalgesia; Indomethacin; Male; Neuralgia; Pain; Pain Threshold; Peripheral Nerve Injuries; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Saccharomyces cerevisiae; Sciatic Nerve; Seminal Vesicles; Sheep; Substance P | 1999 |
Changes in substance P and calcitonin gene-related peptide binding in the dorsal horn of rat spinal cord following pronase-induced deafferentation.
Topics: Animals; Autoradiography; Calcitonin Gene-Related Peptide; Female; Iodine Radioisotopes; Nerve Degeneration; Neuralgia; Neuronal Plasticity; Neurons, Afferent; Pronase; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1999 |
Transmission of chronic nociception by spinal neurons expressing the substance P receptor.
Topics: Animals; Dose-Response Relationship, Drug; Ganglia, Spinal; Immunotoxins; Inflammation; Ligation; N-Glycosyl Hydrolases; Neuralgia; Pain; Plant Proteins; Posterior Horn Cells; Rats; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Spinal Nerves; Substance P; Time Factors | 1999 |
Effects of substance P on excitability and ionic currents of normal and axotomized rat dorsal root ganglion neurons.
Topics: Action Potentials; Animals; Axotomy; Barium; Calcium; Ganglia, Spinal; GTP-Binding Proteins; Male; Neuralgia; Neurons, Afferent; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Substance P | 2001 |
Peptide accumulations in proximal endbulbs of transected axons.
Topics: Animals; Axons; Calcitonin Gene-Related Peptide; Hyperemia; Male; Neuralgia; Neuroma; Neuropeptides; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Substance P; Sural Nerve | 2001 |
Decreases in endomorphin-2-like immunoreactivity concomitant with chronic pain after nerve injury.
Topics: Animals; Calcitonin Gene-Related Peptide; Chronic Disease; Down-Regulation; Functional Laterality; Hyperalgesia; Immunohistochemistry; Ligation; Male; Mice; Mice, Inbred ICR; Nerve Crush; Neuralgia; Oligopeptides; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Posterior Horn Cells; Reaction Time; Sciatic Nerve; Substance P | 2001 |
Effects of dorsal root entry zone lesions on CSF and plasma neuropeptides and catecholamines.
Topics: Adult; beta-Endorphin; Blood-Brain Barrier; Catecholamines; Cyclic AMP; Cyclic GMP; Female; Ganglia, Spinal; Humans; Male; Middle Aged; Neuralgia; Neuropeptides; Pain Measurement; Pain, Intractable; Substance P | 1992 |
Capsaicin in the treatment of dermatologic disease.
Topics: Capsaicin; Herpes Zoster; Humans; Neuralgia; Ointments; Psoriasis; Substance P | 1987 |
Treatment of oral postherpetic neuralgia with topical capsaicin.
Topics: Administration, Topical; Aged; Capsaicin; Herpes Zoster; Humans; Male; Mouth Mucosa; Neuralgia; Substance P | 1988 |