substance p has been researched along with Muscle Contraction in 968 studies
*Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 437 (45.14) | 18.7374 |
| 1990's | 395 (40.81) | 18.2507 |
| 2000's | 107 (11.05) | 29.6817 |
| 2010's | 26 (2.69) | 24.3611 |
| 2020's | 3 (0.31) | 2.80 |
| Authors | Studies |
|---|---|
| Bury, RW; Mashford, ML | 3 |
| Bowers, CY; Fisher, GH; Folkers, K; Pernow, B | 1 |
| Deal, MJ; Hagan, RM; Ireland, SJ; Jordan, CC; McElroy, AB; Porter, B; Ross, BC; Stephens-Smith, M; Ward, P | 1 |
| Appell, KC; Goswami, R; Lawrence, KB; Logan, ME; Tomczuk, BE; Venepalli, BR; Yanni, JM | 1 |
| Brown, JR; Ewan, GB; Hagan, RM; Ireland, SJ; Jordan, CC; Ward, P | 1 |
| Appell, KC; Babb, BE; Goswami, R; Hall, PL; Lawrence, KB; Logan, ME; Przyklek-Elling, R; Tomczuk, BE; Venepalli, BR; Yanni, JM | 1 |
| Briggs, I; Dutta, AS; Gormley, JJ; Graham, AS; Growcott, JW; Jamieson, A | 2 |
| Champagne, G; Couture, R; Escher, E; Mizrahi, J; Regoli, D | 1 |
| Birney, DM; Cole, DC; Crosson, CE; Kahl, BF; Neff, BW; Reid, TW; Ren, K; Walkup, RD | 1 |
| Allen, J; Gembitsky, DS; Lovas, S; Murnin, M; Murphy, RF; Otvös, FL | 1 |
| Chen, W; Dai, F; Luo, H; Qin, B; Quan, X; Wang, J | 1 |
| Chan, SW; Cui, D; Deng, Y; Du, P; Hui, JCM; Jiang, B; Khalid, A; Liu, JYH; Liu, L; Lu, Z; Ng, HSH; Ngan, MP; Rudd, JA; Yang, L | 1 |
| Inui, T; Kato, I; Kuwahara, A; Kuwahara, Y; Marunaka, Y | 1 |
| Fukuta, H; Hashitani, H; Mitsui, R; Takano, H | 1 |
| Breslin, JW; Jo, M; Trujillo, AN; Yang, Y | 1 |
| Akbarali, HI; Al-Qudah, M; Anderson, CD; Bradley, ZL; Grider, JR; Mahavadi, S; Murthy, KS | 1 |
| Bach, V; Canarelli, JP; Delanaud, S; Gay-Quéheillard, J; Haraux, E; Khorsi, H | 1 |
| Li, C; Micci, MA; Murthy, KS; Pasricha, PJ | 1 |
| Arruebo, MP; Gonzalo, S; Grasa, L; Martínez de Salinas, F; Murillo, MD; Plaza, MÁ; Valero, MS; Vergara, C | 1 |
| Akiho, H; Ihara, E; Nakamura, K; Tokita, Y; Yamamoto, M | 1 |
| Chen, W; Cui, N; Fan, H; Luo, H; Quan, X; Tang, Q; Xia, H; Yu, G | 1 |
| Fan, LL; Hou, YP; Kong, XP; Ren, YX; Shao, YF; Wang, C; Xie, JF; Zong, XJ | 1 |
| Fan, H; Luo, H; Quan, X; Tang, Q; Yu, G | 1 |
| Gulak, KL; Paduraru, ON; Philyppov, IB; Prevarskaya, N; Shuba, YM; Skryma, R | 1 |
| Azuma, YT; Hayashi, S; Iwamoto, T; Kita, S; Morioka, A; Nakajima, H; Nishiyama, K; Takeuchi, T; Tanioka, K; Teramoto, M; Yoshida, N | 1 |
| De Smet, B; Depoortere, I; Moechars, D; Peeters, TL; Saels, I; Thijs, T; Ver Donck, L; Verhulst, PJ | 1 |
| Hatano, A; Ishihara, Y; Sekine, M; Shimamoto, N | 1 |
| Dolber, PC; Douglas, KL; Eldaif, BM; Fraser, MO; Jin, H; Nassar, R; Zhang, X | 1 |
| Davis, AM; Davis, MJ; Gashev, AA; Ku, CW | 1 |
| Boudaka, A; Neuhuber, WL; Shiina, T; Shimizu, Y; Takewaki, T; Wörl, J | 1 |
| Burcher, E; King, DW; Liu, L; Lubowski, DZ; Morgan, MJ; Shang, F | 1 |
| Behar, J; Biancani, P; Cao, W; Cheng, L; de la Monte, S; Harnett, KM; Hong, J; Ma, J; Tong, M | 1 |
| Chen, Q; Fu, CY; Han, M; Kong, ZQ; Tao, Y; Wang, R; Yang, WL; Zhao, YL | 1 |
| Horie, S; Hosoya, T; Kurosawa, E; Matsumoto, K; Murayama, T; Priestley, JV; Tashima, K; Terui, H | 1 |
| Duenes, JA; Fatima, J; Iqbal, CW; Kasparek, MS; Sarr, MG | 4 |
| Blennerhassett, MG; Liu, H; Lourenssen, S; Miller, DV; Paterson, WG; Wells, RW | 1 |
| Fujikawa, T; Fukuroda, T; Hirose, H; Ito, J; Kanatani, A; Macneil, DJ; Moriya, R; Shirakura, T; Suzuki, J | 1 |
| Abalo, R; Martín-Fontelles, MI; Moro-Rodríguez, E; Rivera, AJ; Vera, G | 1 |
| Hirayama, H; Kuramoto, H; Shiina, T; Shima, T; Shimizu, Y; Takewaki, T | 1 |
| Grider, JR; Heuckeroth, RO; Kuemmerle, JF; Murthy, KS | 1 |
| Chakraborty, S; Davis, MJ; Muthuchamy, M; Nepiyushchikh, Z; Zawieja, DC | 1 |
| Dong, R; Lu, BS; Zhang, M | 1 |
| Itzev, DE; Negrev, N; Radomirov, R; Stavreva, G | 1 |
| Cipriani, G; Faussone-Pellegrini, MS; Gherghiceanu, M; Serboiu, CS; Vannucchi, MG | 1 |
| Bron, R; Bunnett, NW; Cattaruzza, F; Chiu, JV; Furness, JB; Gai, G; Grady, EF; Kuo, YM; Pelayo, JC; Poole, DP | 1 |
| Emala, CW; Masaki, E; Mizuta, F; Mizuta, K; Panettieri, RA; Xu, D | 1 |
| Henry, PJ; Mann, TS; Taylor, SJ | 1 |
| Barney, SR; Dillon, AR; Tillson, DM; Wooldridge, AA; Zhong, Q | 1 |
| Calo', G; Camarda, V; Campi, B; Cantoreggi, S; Molinari, S; Pietra, C; Regoli, D; Rizzi, A | 1 |
| Chen, FX; Li, YQ; Yu, YB; Yuan, XM; Zuo, XL | 1 |
| Hayashi, H; Oh-ishi, T; Onaga, T; Shimoda, T | 1 |
| Aki, FT; Cetinkaya, M; Gür, S; Oztekin, V; Oztürk, B; Ugurlu, O | 1 |
| Inoue, M; Ono, T; Rashid, MH; Sumikawa, K; Ueda, H | 1 |
| Burmester, M; Jonas, U; Lietz, B; Machtens, SA; Stief, CG; Uckert, S | 1 |
| Geisslinger, G; Meller, ST; Tegeder, L; Zimmermann, J | 1 |
| Barbara, G; Bercík, P; Blennerhassett, P; Collins, SM; De Giorgio, R; Verdú, EF | 1 |
| Dey, RD; Fedan, JS; Satterfield, BE; Wu, ZX | 1 |
| Hirano, K; Kanaide, H; Naito, S; Nishimura, J; Takahashi, R | 1 |
| De Swert, KO; Joos, GF; Leclere, PG; Lefebvre, RA; Pauwels, RA; Tournoy, KG | 1 |
| Chien, CT; Hsu, SM; Lai, MK; Lin, TB; Yu, HJ | 1 |
| Depoortere, I; Peeters, TL; Thielemans, L; Thijs, T | 1 |
| James, AN; Parkman, HP; Ryan, JP | 2 |
| Holmgren, S; Johansson, A | 1 |
| Dey, RD; Satterfield, BE; Wu, ZX | 1 |
| Shea-Donohue, T; Zhao, A | 1 |
| Ahmed, S; Yuan, J | 1 |
| Finkelman, FD; Gause, W; Madden, KB; McDermott, J; Morris, SC; Shea-Donohue, T; Urban, JF; Yeung, KA; Zhao, A | 1 |
| El-Mahmoudy, A; Khalifa, M; Matsuyama, H; Shimizu, Y; Takewaki, T | 1 |
| Hamada, K; Hanioka, N; Imazumi, K; Maeda, Y; Manda, T; Matsuo, M; Mutoh, S; Yamamoto, T | 1 |
| Gokgoz, S; Gursoy, S; Kaya, T; Koyluoglu, G; Saraydin, S; Sen, M | 1 |
| Gillespie, JI | 2 |
| Alves, RV; Calixto, JB; Grumann Júnior, A | 1 |
| Arcari, ML; Ballabeni, V; Barocelli, E; Bertoni, S; Gabella, G; Ghizzardi, P; Impicciatore, M; Lagrasta, C | 1 |
| Kraglund, K; Tottrup, A | 1 |
| Colasurdo, GN; Dakhama, A; Fratelli, C; Larsen, GL; Loader, J; Nguyen, DD | 1 |
| Burcher, E; Holmgren, S; Johansson, A; Liu, L | 1 |
| Baird, AW; Collins, C; Quinn, T | 1 |
| Fujisaki, S; Ikeda, T; Koshinaga, T; Park, E; Tomita, R | 1 |
| De Man, JG; De Schepper, HU; De Winter, BY; Herman, AG; Pelckmans, PA; Seerden, TC | 2 |
| Chan, MH; Kao, PC; Lin, YR | 1 |
| Holmes, EP; Koch, CE; Moore, RM; Sedrish, SA; Venugopal, CS | 1 |
| Danoff, JV; Gerber, LH; Phillips, TM; Shah, JP | 1 |
| Abe, T; Arisaka, O; Morimoto, H; Ohori, M; Yamada, Y; Yoshihara, S | 2 |
| De Man, JG; De Winter, BY; Herman, AG; Pelckmans, PA; Seerden, TC; Van Den Bossche, RM | 1 |
| Ji, M; Lin, L; Lin, Z; Zhang, HJ; Zhao, ZQ | 1 |
| Bianchetti, A; Croci, T; Di Marzo, V; Di Palo, S; Ferla, G; Guagnini, F; Matias, I; Mukenge, S; Valenti, M | 1 |
| Takayama, N; Uchida, K | 1 |
| Dey, RD; Wu, ZX | 1 |
| Fernández, E; Jiménez, M; Tanović, A | 2 |
| Folz, RJ; Liu, JQ; Yang, D | 1 |
| Pinna, C; Puglisi, L; Sanvito, P | 1 |
| Bassil, AK; Cellek, S; Dass, NB; Jarvie, EM; John, AK; Lalude, O; Sanger, GJ; Thangiah, R; Vivekanandan, S | 1 |
| Karaki, SI; Kubo, Y; Kuwahara, A; Mitsui, R; Sugiura, Y | 1 |
| Hiyama, Y; Ishimura, M; Kataoka, S; Maeda, T; Suda, M | 1 |
| Arreola, JL; Chávez, J; Flores-Soto, E; Montaño, LM; Segura, P; Vargas, MH | 1 |
| Cetin, A; Igdem, AA; Ozacmak, ID; Ozacmak, VH; Sayan, H | 1 |
| Chowdhury, JU; Nahar, NS | 1 |
| Hou, YP; Song, YF; Wang, YC; Xie, GL; Zhang, YP; Zhu, CM | 1 |
| Assini, JB; Blennerhassett, MG; Dilworth, N; Lourenssen, S; Miller, DV; Paterson, WG | 1 |
| Amato, A; Mulè, F; Serio, R | 1 |
| Davidson, ME; Lang, RJ | 1 |
| Fatima, J; Iqbal, CW; Kasparek, MS; Sarr, MG | 1 |
| Bynke, G; Håkanson, R; Wahlestedt, C | 1 |
| Tighe, J; Unger, WG | 1 |
| Grunstein, MM; Tanaka, DT | 3 |
| Kanamaru, Y; Komori, S; Ohashi, H | 1 |
| Muramatsu, I; Sofuku, S; Torigoe, K | 1 |
| Collier, HO; Tucker, JF | 1 |
| Goto, K; Kanazawa, I; Kimura, S; Ogawa, T; Sugita, Y | 1 |
| Chahl, LA | 4 |
| Dobry, PJ; Einspahr, FJ; Hollister, RP; Piercey, MF; Schroeder, LA | 1 |
| Fromageot, P; Glowinski, J; Michelot, R; Morgat, JL | 1 |
| Growcott, JW; Petter, NN | 1 |
| Donnerer, J; Holzer, P; Lembeck, F | 1 |
| Luczyńska, M; Traczyk, WZ | 1 |
| Kitabgi, P; Monier, S | 1 |
| Jacquet, YF | 1 |
| Rosell, S | 1 |
| Pinas, N; Poulos, CP; Theodoropoulos, D | 1 |
| Arndorfer, RC; Dent, J; Dodds, WJ; Hogan, WJ; Teeter, BC | 1 |
| Blumberg, S; Teichberg, VI | 1 |
| Bertaccini, G; Coruzzi, G | 1 |
| Choo, LK; Mitchelson, F | 1 |
| Brodin, E; Håkanson, R; Holmin, T; Leander, S; Malmfors, G; Sundler, F | 1 |
| Dockray, GJ; Hutchison, JB | 1 |
| Drabarek, S; Konecka, AM; Lipkowski, AW; Majewski, T; Sadowski, B; Sroczyńska, I | 1 |
| Sowoidnich, T; Zetler, G | 1 |
| Håkanson, R; Leander, S; Sundler, F | 1 |
| Alumets, J; Brodin, E; Håkanson, R; Leander, S; Sundler, F | 1 |
| Blumberg, S; Cohen, S; Teichberg, VI | 1 |
| Abdel-Hakim, AM; Elhilali, M; Rioux, F | 1 |
| Helle, KB; Jørgensen, G; Knudsen, R; Serck-Hassen, G | 1 |
| Emson, PC; Holzer, P; Iversen, LL; Sharman, DF | 1 |
| Bergmann, J; Milenov, K; Nieber, K; Oehme, P | 1 |
| Donnerer, J; Erjavec, F; Florjanc-Irman, T; Holzer, P; Lembeck, F; Saria, A; Skofitsch, G | 1 |
| Dickinson, SL; Slater, P | 1 |
| Couture, R; Devroede, G; Mizrahi, J; Regoli, D | 1 |
| Johns, A | 1 |
| Folkers, K; Håkanson, R; Leander, S; Rosell, S; Sundler, F; Tornqvist, K | 1 |
| Cascieri, MA; Goldenberg, MM; Liang, T | 1 |
| Håkanson, R; Leander, S; Lorén, I; Mandahl, A; Sundler, F; Tornqvist, K | 1 |
| Caranikas, S; D'Orléans-Juste, P; Mizrahi, J; Regoli, D | 1 |
| Barthó, L; Sebök, B; Szolcsányi, J | 1 |
| Brundish, DE; Eison, AS; Hanley, MR; Sandberg, BE; Wade, R; Watson, SP | 1 |
| Barker, LA; Ebersole, BJ | 1 |
| Fujiwara, M; Muramatsu, I; Sakakibara, Y; Ueda, N | 1 |
| Couture, R; Regoli, D | 1 |
| Andersson, RG; Grundström, N; Wikberg, JE | 1 |
| Angel, F; Go, VL; Morgan, KG; Schmalz, PF; Szurszewski, JH | 1 |
| Gintzler, AR; Scalisi, JA | 1 |
| Hanley, MR; Iversen, LL; Lee, CM; Sandberg, BE | 1 |
| Bertaccini, G; Zappia, L | 1 |
| Bucsics, A; Gamse, R; Lembeck, F; Saria, A | 1 |
| Broccardo, M; Erspamer, GF; Erspamer, V; Falaschi, P; Improota, G; Melchiorri, P; Negri, L; Renda, T | 1 |
| Christensen, J | 1 |
| Andersson, KE; Husted, S; Sjögren, C | 1 |
| Hawcock, AB; Hayes, AG; Tyers, MB | 1 |
| Butler, JM; Cole, DF; Ohara, K; Zhang, SQ | 1 |
| Holzer, P | 3 |
| Cahusac, PM; De Vries, GJ; Hill, RG; Morris, R; Rodriguez, RE; Salt, TE | 1 |
| Nieber, K; Oehme, P | 1 |
| Dobry, PJ; Einspahr, FJ; Masiques, N; Piercey, MF; Schroeder, LA | 1 |
| Bahouth, S; Chelala, CA; Huidobro-Toro, JP; Musacchio, JM; Nodar, R | 1 |
| Louie, G; Tsou, K; Way, EL | 1 |
| Caranikas, S; Couture, R; Mizrahi, J; Regoli, D | 1 |
| Caranikas, S; D'orléans-Juste, P; Escher, E; Mizrahi, J; Regoli, D | 1 |
| Björkroth, U; Folkers, K; Hörig, J; Lane, P; Rampold, G; Rosell, S | 1 |
| Ahlman, H; Dahlström, A; Edin, R; Folkers, K; Lidberg, P; Lundberg, JM; Rosell, S | 1 |
| von Euler, US | 1 |
| Allen, MC; Brundish, DE; Hanley, MR; Iversen, LL; Sandberg, BE; Wade, R | 1 |
| Couture, R; Escher, E; Mizrahi, J; Pinas, N; Poulos, C; Regoli, D; Theodoropoulos, D | 1 |
| Fujiwara, M; Hayashi, H; Muramatsu, I; Ueda, N | 3 |
| Milenov, K; Nieber, K; Oehme, P | 2 |
| Brodin, E; Håkanson, R; Leander, S; Sundler, F; Uddman, R | 1 |
| North, RA; Yokoyama, S | 1 |
| Håkanson, R; Hörig, J; Leander, S | 1 |
| Barthó, L; Holzer, P; Lembeck, F; Szolcsányi, J | 1 |
| Van Miert, AS; Veenendaal, GH; Woutersen-van Nijnanten, FM | 1 |
| Growcott, JW; Jamieson, A; Tarpey, AV; Topham, LD | 1 |
| Adrian, TE; Allen, JM; Bloom, SR; Hughes, J; Polak, JM; Tatemoto, K | 1 |
| Mathison, R | 1 |
| Björkroth, U; Folkers, K; Rosell, S; Xu, JC | 2 |
| Holmgren, S | 1 |
| Holzer, P; Lembeck, F | 2 |
| Lundberg, JM; Saria, A | 1 |
| Lavielle, S; Marquet, A; Poujade, C; Torrens, Y | 1 |
| Burleigh, DE | 1 |
| Andersson, PO; Bloom, SR; Järhult, J | 1 |
| Lin, CW; Musacchio, JM | 1 |
| Golenhofen, K; Milenov, K | 1 |
| Barnwell, SL; Janson, VE; Owens, LK; Sastry, BV; Tayeb, OS | 1 |
| Andersson, RG; Håkanson, R; Hörig, J; Leander, S | 1 |
| Fujino, M; Kitada, C; Murakoshi, T; Otsuka, M; Yanagisawa, M | 1 |
| Håkanson, R; Leander, S; Nilsson, S; Vallgren, S | 1 |
| Chassaing, G; Lavielle, S; Marquet, A | 1 |
| Collins, SM; Daniel, EE; Fox, AE; Fox, JE; Jury, J | 1 |
| D'Orléans-Juste, P; Drapeau, G; Escher, E; Mizrahi, J; Regoli, D | 3 |
| Barthó, L; Holzer, P; Lembeck, F; Lippe, IT | 1 |
| Angel, F; Go, VL; Schmalz, PF; Szurszewski, JH | 1 |
| Björkroth, U | 1 |
| Holzer, P; Petsche, U | 1 |
| Abdel-Hakim, A; Abdel-Rahman, M; Elhilali, M; Galeano, C; Hassouna, M; Rioux, F; St-Pierre, S | 1 |
| Downes, CP; Watson, SP | 1 |
| Håkanson, R; Leander, S; Owman, C; Stjernquist, M; Sundler, F; Uddman, R | 1 |
| Lundberg, JM; Martling, CR; Saria, A | 1 |
| Bergmann, J | 1 |
| Karlsson, JA; Persson, CG | 1 |
| Watson, SP | 3 |
| Kobayashi, S; Suzuki, R | 1 |
| Andersson, PO; Bloom, SR; Edwards, AV; Järhult, J; Mellander, S | 1 |
| Björkroth, U; Folkers, K; Liu, YZ; Lu, YA; Rosell, S; Xu, JC | 1 |
| Barja, F; Immer, H; Mathison, R; Stofer, P | 1 |
| Gumulka, WS; Lipkowski, AW; Osipiak, B | 1 |
| Fahrenkrug, J; Ottesen, B; Söndergaard, F | 1 |
| Fujiwara, M; Muramatsu, I; Ueda, N | 3 |
| Chorev, M; Friedman, ZY; Gilon, C; Laufer, R; Selinger, Z; Wormser, U | 2 |
| Kamikawa, Y; Shimo, Y | 2 |
| D'Orléans-Juste, P; Escher, E; Mizrahi, J; Regoli, D | 2 |
| Gerstenberg, T; Hald, T; Klarskov, P | 1 |
| Doteuchi, M; Igano, K; Inouye, K; Nakanishi, S; Nawa, H | 1 |
| Brodin, E; Hua, X; Lundberg, JM; Saria, A | 1 |
| Bergmann, J; Bienert, M; Köller, G; Mezö, I; Niedrich, H; Oehme, P | 1 |
| Endoh, K; Ishida, Y; Kiso, Y; Kotani, M; Moritoki, H; Takei, M | 1 |
| Chang, RS; Chen, TB; Lotti, VJ | 1 |
| Andersson, RG; Grundström, N; Håkanson, R; Leander, S | 1 |
| Foreman, JC; Webber, SE | 1 |
| Hourani, SM | 1 |
| Primor, N | 1 |
| Holzer, P; Lippe, IT | 3 |
| Bailey, SJ; Jordan, CC | 1 |
| Bolger, GT; Gengo, P; Jim, K; Siegel, H; Triggle, DJ | 1 |
| Featherstone, RL; Fosbraey, P; Morton, IK | 2 |
| Ishii, T; Shimo, Y | 2 |
| Kadlec, O; Masek, K; Seferna, I | 1 |
| Maggi, CA; Meli, A; Santicioli, P | 2 |
| Christensen, J; Percy, WH | 2 |
| Folkers, K; Håkanson, R; Hörig, J; Leander, S; Xu, JC | 1 |
| Hörig, J; Schultheiss, H | 1 |
| Iversen, LL; Watson, SP | 1 |
| Chang, G; Diamant, NE; El-Sharkawy, TY; Huizinga, JD | 1 |
| Angel, F; Go, VL; Szurszewski, JH | 1 |
| Ma, QP; Woolf, CJ | 1 |
| Beaujouan, JC; Glowinski, J; Saffroy, M; Torrens, Y | 1 |
| Fujiwara, Y; Ishii, H; Kusunoki, M; Nakao, K; Utsunomiya, J; Yamamura, T | 1 |
| Longmore, J; Razzaque, Z | 1 |
| Bertrand, C; Daffonchio, L; Geppetti, P; Huber, O; Nadel, JA; Omini, C; Yamawaki, I | 1 |
| Igić, R | 1 |
| Hagan, RM; Jordan, CC; Karagiannis, K; Poulos, C; Stavropoulos, G | 1 |
| Barrow, CJ; Bobko, MA; Cooper, R; Doleman, MS | 1 |
| Akkermans, LM; Briejer, MR; Lefebvre, RA; Meulemans, AL; Schuurkes, JA | 1 |
| Boccio, D; Carruette, A; Garret, C; Montier, F; Moussaoui, S | 1 |
| Lot, TY; Wilson, VG | 1 |
| He, GW; Rebeyka, IM; Wilson, GJ; Yang, CQ | 1 |
| Burcher, E; Lavielle, S; Zeng, XP | 1 |
| Grider, JR; Jin, JG | 1 |
| Appell, KC; Barrow, CJ; Casiano, F; Gillum, AM; Haycock, D; Kaplita, P; Oleynek, JJ; Sedlock, DM; Ward, SJ | 1 |
| Cenarruzabeitia, E; Del Río, J; Lasheras, B; Ramírez, MJ | 2 |
| Barnes, PJ; Belvisi, MG; Maggi, CA; Patacchini, R | 1 |
| Maggi, CA; Meini, S; Patacchini, R | 1 |
| Alkon, J; Coburn, RF; Dey, RD; Mitchell, H | 1 |
| Gomi, Y; Mizuno, K; Suzuki, N | 2 |
| Maggi, CA; Santicioli, P; Zagorodnyuk, V | 1 |
| Funayama, N; Goroumaru-Shinkai, M; Takayanagi, I | 1 |
| Barnes, PJ; Belvisi, MG; Takahashi, T | 1 |
| Hill, RG; Longmore, J; Razzaque, Z; Shaw, D | 1 |
| Giachetti, A; Giuliani, S; Maggi, CA; Meini, S; Patacchini, R; Potier, E; Quartara, L; Sisto, A | 1 |
| Bodelsson, G; Stjernquist, M | 1 |
| Ishizawa, M | 1 |
| Fernández, AG; Fernández, E; Goñalons, E; Martín, MT | 1 |
| Ally, A; Meintjes, AF; Mitchell, JH; Wilson, LB | 1 |
| Corsi, M; Gaviraghi, G; Oliosi, B; Palea, S; Pietra, C; Sugg, E; Trist, DG; Van Amsterdam, FT | 1 |
| Beck, JK; Kojda, G; Meyer, W; Noack, E | 1 |
| Lin, KW; Liu, X | 1 |
| Brunissen, A; Carruette, A; Chassaing, G; Garret, C; Lavielle, S | 1 |
| Hall, JM; Mitchell, D; Morton, IK | 1 |
| Bertrand, C; Da Silva, A; Landry, Y | 1 |
| Burcher, E; Zeng, XP | 1 |
| Hull, AD; Pearce, WJ; White, CR | 1 |
| Janssen, LJ; Sims, SM | 1 |
| Barthó, L; Maggi, CA; Patacchini, R; Wilhelm, M | 1 |
| Feng, DM; Folkers, K; Håkanson, R; Strichartz, GR; Tung, SR; Wang, YL; Wang, ZY; Wong, K | 1 |
| Jin, SZ; Li, J; Yang, HS; Zhang, HJ | 1 |
| Botella, A; Bueno, L; Delvaux, M; Fioramonti, J; Frexinos, J | 1 |
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| Fuchs, IE; Leshnower, B; Li, J; Mitchell, JH; Potts, JT | 1 |
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| Matsukawa, K; Mitchell, JH; Wall, PT; Wilson, LB | 1 |
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| Holzer-Petsche, U; Lembeck, F; Seitz, H | 1 |
| Homma, S; Karakida, T; Liu, HS | 1 |
| Hökfelt, T; Villar, MJ; Wiesenfeld-Hallin, Z | 1 |
| Kitamura, S | 1 |
| Kamikawa, Y | 1 |
| Arnbjörnsson, E; Ekblad, E; Ekman, R; Håkanson, R; Sundler, F | 1 |
| Kuwahara, A; Ozaki, T; Yanaihara, N | 1 |
| Astolfi, M; Del Bianco, E; Geppetti, P; Giuliani, S; Maggi, CA; Meli, A; Parlani, M; Patacchini, R; Santicioli, P | 1 |
| Milenov, K; Nieber, K; Oehme, P; Rakovska, A | 1 |
| Pernow, J | 1 |
| Minami, Y; Onoue, H; Toda, N | 1 |
| Drapeau, G; Maggi, CA; Meli, A; Patacchini, R; Regoli, D; Renzi, D; Rovero, P; Santicioli, P; Surrenti, C | 1 |
| Hertel, W; Penzlin, H; Wieduwilt, I | 1 |
| García-Antón, JM; Haro, I; Reig, F; Torres, JL; Valencia, G | 1 |
| Dai, YL; Ge, ZH; Li, DS; Xiao, QA | 1 |
| Advenier, C; Bakdach, H; Devillier, P; Drapeau, G; Naline, E; Regoli, D; Toty, L | 1 |
| Bowker, P; Cipris, S; Daniel, EE; Manaka, Y; Regoli, D | 1 |
| Burnstock, G; Stewart-Lee, A | 1 |
| Barnes, PJ; Belvisi, MG; Ichinose, M | 1 |
| Mizutani, M; Nakayama, S; Neya, T | 1 |
| Abelli, L; Conti, S; Del Bianco, E; Geppetti, P; Maggi, CA; Manzini, S; Somma, V | 1 |
| Maggi, CA; Meli, A; Patacchini, R; Rovero, P | 1 |
| Dem'ianenko, VS; Shmigol', AV | 1 |
| Anania, MC; Boschero, L; Coy, DH; Delle Fave, G; Jensen, RT; Severi, C | 1 |
| Hyman, PE; Kimura, S; Snape, WJ; Tomomasa, T; Yagi, H | 1 |
| Elguero, J; García-Antón, JM; Goya, P; Haro, I; Martínez, A; Reig, F | 1 |
| Kamidono, S; Nakanishi, T; Shirakawa, J; Tanaka, C; Taniyama, K | 1 |
| Cecconi, R; Geppetti, P; Giuliani, S; Maggi, CA; Meli, A; Patacchini, R; Santicioli, P | 1 |
| Burcher, E; Lew, R; Mussap, CJ | 1 |
| Guttman, FM; Sonnino, RE; Taguchi, T; Zorchta, E | 1 |
| Booth, AM; de Groat, WC; Kawatani, M; Whitney, T | 1 |
| Barbanti, G; Beneforti, P; Maggi, CA; Meli, A; Patacchini, R; Rovero, P; Santicioli, P; Turini, D | 1 |
| Berkenboom, G; Degre, S; Fang, ZY; Fontaine, J; Unger, P | 1 |
| Morita, K; Munakata, K; Tomita, R | 1 |
| García-Antón, JM; Haro, I; Reig, F; Rodriguez, RE; Ruiz, P; Valencia, G | 1 |
| Connor, HE; Edwards, LA; Feniuk, W | 1 |
| Kuga, T; Nishiyama, M; Ootsuki, K | 1 |
| Russell, JA | 1 |
| Beding, B; Bynke, G; Håkanson, R; Wahlestedt, C | 1 |
| Fischer, JA; Franco-Cereceda, A; Hökfelt, T; Hua, X; Lundberg, JM | 1 |
| Mathison, R; Solomos, D | 1 |
| Bornstein, J; Costa, M; Furness, JB; Pullin, CO | 1 |
| Jörnvall, H; Lundberg, JM; Mutt, V; Tatemoto, K | 1 |
| Kaufman, MP; Kozlowski, GP; Rybicki, KJ | 1 |
| Buchheit, KH; Engel, G; Mutschler, E; Richardson, B | 1 |
| Singh, I | 3 |
| Diniz, CR; Hial, V; Pittella, JE; Tafuri, WL | 1 |
| Iven, H; Zetler, G | 1 |
| Juan, H; Lembeck, F | 1 |
| Sjöstrand, NO; Swedin, G | 1 |
| Falconieri Erspamer, G; Negri, L; Piccinelli, D | 1 |
| Pinitsch, B; Umrath, K | 1 |
| Bergmann, J; Bienert, M; Niedrich, H; Oehme, P | 1 |
| Hedqvist, P; von Euler, US | 1 |
| Bowers, CY; Fisher, GH; Folkers, K; Humphries, J; Pernow, B | 1 |
| Bergmann, J; Bienert, M; Mehlis, B; Niedrigh, H; Oehme, P | 1 |
| Chang, MM; Leeman, SE | 1 |
| Antopol, W; Chryssanthou, C | 1 |
| Cîrstea, M | 1 |
| Buzzo, H | 1 |
16 review(s) available for substance p and Muscle Contraction
| Article | Year |
|---|---|
Sites and mechanisms of dependence in the myenteric plexus of guinea pig ileum.
Topics: Acetylcholine; Adenosine; Animals; Clonidine; Cyclic AMP; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Morphine; Morphine Dependence; Morphine Derivatives; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Pertussis Vaccine; Scopolamine; Substance P; Substance Withdrawal Syndrome; Substance-Related Disorders; Theophylline; Yohimbine | 1984 |
Mini review: smooth muscle pharmacology of substance P.
Topics: Animals; Blood Pressure; Dogs; Guinea Pigs; Heart; Ileum; In Vitro Techniques; Kinins; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Peptides; Rabbits; Rats; Rats, Inbred Strains; Substance P | 1982 |
The brain-gut-skin triangle: new peptides.
Topics: Adrenocorticotropic Hormone; Amino Acid Sequence; Amphibian Proteins; Analgesia; Animals; Behavior, Animal; beta-Endorphin; Bombesin; Brain; Digestive System; Endorphins; Gastric Acid; Gastric Emptying; Hemodynamics; Histocytochemistry; Humans; Muscle Contraction; Muscle, Smooth; Oligopeptides; Opioid Peptides; Peptide Hormones; Peptides; Pituitary Hormones, Anterior; Prolactin; Protein Conformation; Skin; Substance P; Tachykinins | 1981 |
Are the proposed substance P receptor sub-types, substance P receptors?
Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Eledoisin; Hydrolysis; Kassinin; Muscle Contraction; Neurokinin B; Oligopeptides; Peptide Fragments; Phospholipids; Physalaemin; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Structure-Activity Relationship; Substance P | 1984 |
Regulation of tone in penile cavernous smooth muscle. Established concepts and new findings.
Topics: Adenosine Triphosphate; Animals; Arginine Vasopressin; Calcitonin Gene-Related Peptide; Endothelins; Endothelium, Vascular; Histamine; Humans; Male; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Smooth, Vascular; Neuromuscular Junction; Neuropeptide Y; Nitric Oxide; Penile Erection; Penis; Prostaglandins; Substance P; Synaptic Transmission; Vasoactive Intestinal Peptide | 1994 |
Physiology of the vas deferens.
Topics: Animals; Arginine Vasopressin; Calcitonin Gene-Related Peptide; Galanin; Humans; Male; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Neuropeptide Y; Neuropeptides; Pancreatic Polypeptide; Peptides; Substance P; Synaptic Transmission; Vas Deferens; Vasoactive Intestinal Peptide | 1994 |
[Substance P receptor antagonist].
Topics: Amino Acid Sequence; Animals; Dactinomycin; In Vitro Techniques; Molecular Sequence Data; Muscle Contraction; Neprilysin; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Platelet Aggregation; Receptors, Neurokinin-1; Substance P; Tachykinins | 1993 |
[The peripheral pharmacology of erection].
Topics: Acetylcholine; Arteries; Calcitonin Gene-Related Peptide; Calcium; Collagen; Cyclic AMP; Cyclic GMP; Endothelins; Gap Junctions; Humans; Ion Exchange; Male; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Smooth; Muscle, Smooth, Vascular; Neuropeptide Y; Nitric Oxide; Norepinephrine; Oxygen Consumption; Parasympathetic Nervous System; Penile Erection; Penis; Regional Blood Flow; Second Messenger Systems; Substance P; Sympathetic Nervous System; Transforming Growth Factor beta | 1997 |
Nociceptin effects in the airways.
Topics: Acetylcholine; Animals; Bronchi; Bronchoconstriction; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Electric Stimulation Therapy; Electrophysiology; Guinea Pigs; Humans; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Neurotransmitter Agents; Nociceptin; Opioid Peptides; Rats; Substance P; Trachea; Vasodilator Agents | 2000 |
Putative peptide neurotransmitters.
Topics: Angiotensin II; Animals; Anura; Carnosine; Cats; Cattle; Enkephalins; Muscle Contraction; Muscle, Smooth; Neurons; Neurotransmitter Agents; Oligopeptides; Peptides; Pituitary Gland; Pituitary Hormone-Releasing Hormones; Rats; Spinal Cord; Structure-Activity Relationship; Substance P | 1977 |
Pharmacology of colonic muscle.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Angiotensin II; Antidiarrheals; Atropine; Bradykinin; Cathartics; Cholecystokinin; Colon; Electric Stimulation; Gastrointestinal Motility; Histamine; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Norepinephrine; Prostaglandins; Serotonin; Substance P | 1975 |
On the role of substance P and serotonin in the pyloric motor control. An experimental study in cat and rat.
Topics: Animals; Blood Pressure; Cats; Electric Stimulation; Female; Fluorescent Antibody Technique; Gastric Emptying; Hot Temperature; Injections, Intra-Arterial; Male; Muscle Contraction; Muscle, Smooth; Pyloric Antrum; Rats; Serotonin; Serotonin Antagonists; Species Specificity; Splanchnic Nerves; Substance P; Tachyphylaxis; Vagus Nerve | 1985 |
Calcitonin gene-related peptide: novel neuropeptide.
Topics: Acetylcholine; Animals; Blood Pressure; Brain; Brain Chemistry; Calcitonin; Calcitonin Gene-Related Peptide; Carcinoma; Drug Synergism; Heart Rate; Histocytochemistry; Humans; Muscle Contraction; Muscle, Smooth; Nerve Fibers; Nerve Tissue Proteins; Peripheral Nerves; Receptors, Calcitonin; Receptors, Cell Surface; Regional Blood Flow; RNA, Messenger; Spinal Cord; Substance P; Thyroid Gland; Thyroid Neoplasms; Tissue Distribution; Transcription, Genetic; Vasodilation | 1986 |
Search for a physiological role of substance P in gastrointestinal motility.
Topics: Acetylcholine; Animals; Atropine; Capsaicin; Drug Resistance; Endorphins; Gastrointestinal Motility; Humans; Ileum; Muscle Contraction; Nerve Fibers; Neural Inhibition; Neurons; Peristalsis; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Somatostatin; Splanchnic Nerves; Structure-Activity Relationship; Substance P; Vagus Nerve | 1985 |
Mediation of pulmonary immunity and hypersensitivity by neuropeptides.
Topics: Animals; Basophils; Humans; Leukocytes; Lung; Mast Cells; Muscle Contraction; Muscle, Smooth; Nerve Tissue Proteins; Neutrophils; Receptors, Cell Surface; Respiratory Hypersensitivity; Somatostatin; Substance P | 1986 |
Influence of neuropeptides on airway smooth muscle.
Topics: Animals; Autonomic Nervous System; Drug Interactions; Guinea Pigs; Lung Diseases; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neuropeptides; Neurotransmitter Agents; Receptors, Neurotransmitter; Respiratory Physiological Phenomena; Respiratory System; Substance P; Vasoactive Intestinal Peptide | 1987 |
2 trial(s) available for substance p and Muscle Contraction
| Article | Year |
|---|---|
Release of algesic substances in human experimental muscle pain.
Topics: Adult; Arm; Dinoprostone; Exercise; Female; Glutamic Acid; Humans; Hypertonic Solutions; Inflammation; Lactic Acid; Leg; Male; Microdialysis; Muscle Contraction; Muscle Fatigue; Muscle, Skeletal; Nitric Oxide; Pain; Pain Measurement; Sodium Chloride; Substance P; Time Factors | 2002 |
An in vivo microanalytical technique for measuring the local biochemical milieu of human skeletal muscle.
Topics: Bradykinin; Calcitonin Gene-Related Peptide; Electromyography; Humans; Hydrogen-Ion Concentration; Microdialysis; Muscle Contraction; Muscle, Skeletal; Norepinephrine; Pain Threshold; Serotonin; Substance P; Tumor Necrosis Factor-alpha | 2005 |
950 other study(ies) available for substance p and Muscle Contraction
| Article | Year |
|---|---|
Biological activity of C-terminal partial sequences of substance P.
Topics: Amino Acid Sequence; Amino Acids; Animals; Chromatography, Thin Layer; Countercurrent Distribution; Dogs; Ear; Guinea Pigs; Hindlimb; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Rabbits; Regional Blood Flow; Substance P; Veins | 1976 |
Synthesis and some biological activities of the tyrosine-8 analog of substance P.
Topics: Animals; Blood Pressure; Dogs; Female; Follicle Stimulating Hormone; Guinea Pigs; Ileum; In Vitro Techniques; Luteinizing Hormone; Muscle Contraction; Muscle, Smooth; Pituitary Gland; Rats; Substance P; Tyrosine | 1976 |
Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists.
Topics: Amino Acid Sequence; Animals; Guinea Pigs; In Vitro Techniques; Lactams; Male; Models, Molecular; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Protein Conformation; Rats; Receptors, Neurotransmitter; Receptors, Tachykinin; Stereoisomerism; Structure-Activity Relationship; Tachykinins | 1992 |
Synthesis and substance P antagonist activity of naphthimidazolium derivatives.
Topics: Animals; Binding, Competitive; Edema; Female; Guinea Pigs; Ileum; Imidazoles; Indoles; Male; Molecular Structure; Muscle Contraction; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Salivation; Structure-Activity Relationship; Substance P | 1992 |
Potent and highly selective neurokinin antagonists.
Topics: Amino Acid Sequence; Animals; Guinea Pigs; In Vitro Techniques; Intestinal Mucosa; Intestines; Molecular Sequence Data; Molecular Structure; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Protein Conformation; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Neurotransmitter; Structure-Activity Relationship; Substance P | 1990 |
Imidazo[4,5-b]quinoxaline cyanines as neurokinin antagonists.
Topics: Animals; Chemical Phenomena; Chemistry; Guinea Pigs; Imidazoles; Muscle Contraction; Muscle, Smooth; Neurokinin A; Quinoxalines; Rats; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Structure-Activity Relationship | 1991 |
Analogues of substance P. Peptides containing D-amino acid residues in various positions of substance P and displaying agonist or receptor selective antagonist effects.
Topics: Amino Acid Sequence; Amino Acids; Animals; Blood Pressure; Guinea Pigs; Hypertension; In Vitro Techniques; Indicators and Reagents; Muscle Contraction; Muscle, Smooth; Rabbits; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Stereoisomerism; Structure-Activity Relationship; Substance P | 1986 |
Synthesis and biological activities of photoaffinity labeling analogues of substance P.
Topics: Affinity Labels; Animals; Chemical Phenomena; Chemistry; Chemistry, Physical; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Substance P | 1982 |
Use of beta-methylphenylalanine (beta MeF) residues to probe the nature of the interaction of substance P with its receptor: effects of beta MeF-containing substance P analogs on rabbit iris smooth muscle contraction.
Topics: Aminobutyrates; Animals; Iris; Molecular Probes; Muscle Contraction; Muscle, Smooth; Rabbits; Receptors, Neurokinin-1; Substance P | 1995 |
Importance of the aromatic residue at position 6 of [Nle(10)]neurokinin A(4-10) for binding to the NK-2 receptor and receptor activation.
Topics: Animals; Binding, Competitive; CHO Cells; Cricetinae; Humans; In Vitro Techniques; Male; Mesocricetus; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Receptors, Neurokinin-2; Structure-Activity Relationship; Trachea | 1999 |
The excitatory effect of hydrogen sulfide on rat colonic muscle contraction and the underlying mechanism.
Topics: Animals; Colon; Hydrogen Sulfide; Muscle Contraction; Muscle, Smooth; Myocytes, Smooth Muscle; Rats; Substance P | 2022 |
Regional differences of tachykinin effects on smooth muscle and pacemaker potentials of the stomach, duodenum, ileum and colon of an emetic model, the house musk shrews.
Topics: Animals; Colon; Duodenum; Emetics; Ileum; Muscle Contraction; Muscle, Smooth; Neurokinin A; Receptors, Neurokinin-2; Shrews; Stomach; Substance P; Tachykinins | 2023 |
The effect of Xenin25 on spontaneous circular muscle contractions of rat distal colon in vitro.
Topics: Animals; Colon; Enteric Nervous System; Gastrointestinal Agents; Gastrointestinal Motility; In Vitro Techniques; Male; Muscle Contraction; Muscle, Skeletal; Neural Inhibition; Neurotensin; Nitrergic Neurons; Rats, Sprague-Dawley; Receptors, Neurotensin; Substance P; Vasoactive Intestinal Peptide | 2021 |
Contractile properties of periosteal arterioles in the guinea-pig tibia.
Topics: Animals; Arterioles; Calcitonin Gene-Related Peptide; Guinea Pigs; Male; Muscle Contraction; Neurotransmitter Agents; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; Periosteum; Phentolamine; Receptors, Neurokinin-1; Sarcoplasmic Reticulum; Substance P; Sympathetic Nervous System; Tibia; Vasoconstriction; Vasodilation | 2017 |
Evidence of functional ryanodine receptors in rat mesenteric collecting lymphatic vessels.
Topics: Animals; Caffeine; Calcium Signaling; Lymphatic Vessels; Male; Mesentery; Muscle Contraction; Muscle, Smooth; Rats, Sprague-Dawley; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Substance P | 2019 |
Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C.
Topics: Animals; Brain-Derived Neurotrophic Factor; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Jejunum; Muscle Contraction; Muscle, Smooth; Phosphorylation; Rabbits; Receptor, trkB; Signal Transduction; Substance P; Type C Phospholipases | 2014 |
In vitro smooth muscle contractility before and after relief of experimental obstruction in the rat: application to the surgical management of ileal dilatation.
Topics: Acetylcholine; Animals; Dilatation, Pathologic; Disease Models, Animal; Electric Stimulation; Gastrointestinal Motility; Histamine; Ileal Diseases; In Vitro Techniques; Intestinal Obstruction; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Postoperative Period; Potassium Chloride; Random Allocation; Rats; Rats, Wistar; Substance P | 2014 |
Substance P is essential for maintaining gut muscle contractility: a novel role for coneurotransmission revealed by botulinum toxin.
Topics: Acetylcholine; Animals; Biphenyl Compounds; Botulinum Toxins; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Pyloric Antrum; Pylorus; Rats; Receptors, Neurokinin-1; Substance P | 2014 |
Roles of Toll-Like Receptor 4, IκB Kinase, and the Proteasome in the Intestinal Alterations Caused by Sepsis.
Topics: Acetylcholine; Animals; Cell-Penetrating Peptides; Cytokines; Dinoprostone; Disease Models, Animal; Duodenum; Endotoxins; Gastrointestinal Motility; Gene Expression Regulation; I-kappa B Kinase; Inflammation Mediators; Leupeptins; Male; Muscle Contraction; Neomycin; Polymyxin B; Potassium Chloride; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinase Inhibitors; Rabbits; Sepsis; Signal Transduction; Substance P; Toll-Like Receptor 4 | 2015 |
Contraction of gut smooth muscle cells assessed by fluorescence imaging.
Topics: Animals; Cell Separation; Cells, Cultured; Dinoprostone; Dose-Response Relationship, Drug; Drug Discovery; Fatty Acids, Unsaturated; Gastrointestinal Motility; Histamine; Intestine, Small; Male; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Optical Imaging; Panax; Plant Extracts; Polyunsaturated Alkamides; Serotonin; Stimulation, Chemical; Substance P; Zanthoxylum; Zingiberaceae | 2015 |
Brain-Derived Neurotrophic Factor Contributes to Colonic Hypermotility in a Chronic Stress Rat Model.
Topics: Animals; Blotting, Western; Brain-Derived Neurotrophic Factor; Colon; Gastrointestinal Motility; Immunohistochemistry; In Vitro Techniques; Intestinal Mucosa; Male; Membrane Glycoproteins; Models, Animal; Muscle Contraction; Muscle, Smooth; Rats, Wistar; Stress, Psychological; Substance P; Up-Regulation | 2015 |
The Inhibitory Effect of Botulinum Toxin Type A on Rat Pyloric Smooth Muscle Contractile Response to Substance P In Vitro.
Topics: Animals; Botulinum Toxins, Type A; Electric Stimulation; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Myoelectric Complex, Migrating; Pylorus; Rats, Sprague-Dawley; Substance P | 2015 |
[Effect of substance P on the potassium and calcium currents of colonic smooth muscle cells].
Topics: Animals; Calcium; Calcium Channels, L-Type; Colon; Large-Conductance Calcium-Activated Potassium Channels; Male; Muscle Contraction; Muscle, Smooth; Patch-Clamp Techniques; Potassium; Rats; Substance P | 2015 |
TRPA1-dependent regulation of bladder detrusor smooth muscle contractility in normal and type I diabetic rats.
Topics: Animals; Cyclooxygenase 2; Diabetes Mellitus, Experimental; Male; Muscle Contraction; Muscle, Smooth; Prostaglandins; Rats, Wistar; Streptozocin; Substance P; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels; Urinary Bladder | 2016 |
Roles of Na(+)/Ca(2+) exchanger isoforms NCX1 and NCX2 in motility in mouse ileum.
Topics: Acetylcholine; Animals; Electric Stimulation; Gastrointestinal Motility; Genotype; Ileum; In Vitro Techniques; Mice, Inbred C57BL; Mice, Knockout; Muscle Contraction; Muscle, Smooth; Phenotype; Sodium-Calcium Exchanger; Substance P | 2016 |
Role of ghrelin in the relationship between hyperphagia and accelerated gastric emptying in diabetic mice.
Topics: Acetylcholine; Agouti-Related Protein; Animals; Blood Glucose; Body Weight; Cholinergic Agents; Diabetes Mellitus, Experimental; Eating; Gastric Emptying; Gastric Fundus; Ghrelin; Hyperphagia; Hypothalamus; Male; Mice; Mice, Knockout; Muscle Contraction; Neuropeptide Y; Neurotransmitter Agents; Pro-Opiomelanocortin; Receptors, Ghrelin; RNA, Messenger; Substance P | 2008 |
Sustained contraction and endothelial dysfunction induced by reactive oxygen species in porcine coronary artery.
Topics: Animals; Calcium Channels, L-Type; Coronary Vessels; Endothelium; Heart; Hydrogen Peroxide; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Purines; Reactive Oxygen Species; Substance P; Superoxide Dismutase; Superoxides; Swine | 2008 |
Sprouting of substance P-expressing primary afferent central terminals and spinal micturition reflex NK1 receptor dependence after spinal cord injury.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Electromyography; Female; Injections, Spinal; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Pressure; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Reflex; Spinal Cord Ischemia; Spinal Nerves; Substance P; Time Factors; Urinary Bladder; Urination | 2008 |
Myogenic constriction and dilation of isolated lymphatic vessels.
Topics: Animals; Constriction, Pathologic; Dilatation, Pathologic; In Vitro Techniques; Inflammation Mediators; Lymphatic Vessels; Male; Mesentery; Muscle Contraction; Muscle Relaxation; Pressure; Rats; Rats, Sprague-Dawley; Substance P; Time Factors | 2009 |
Galanin modulates vagally induced contractions in the mouse oesophagus.
Topics: Alkaloids; Animals; Benzodioxoles; Capsaicin; Electric Stimulation; Enzyme Inhibitors; Esophagus; Female; Galanin; Indoles; Male; Mice; Muscle Contraction; NG-Nitroarginine Methyl Ester; Phenanthrolines; Piperidines; Polyunsaturated Alkamides; Receptors, Galanin; Sensory System Agents; Substance P; Vagus Nerve | 2009 |
Cyclooxygenase-dependent alterations in substance P-mediated contractility and tachykinin NK1 receptor expression in the colonic circular muscle of patients with slow transit constipation.
Topics: Acetylcholine; Adult; Aged; Aging; Atropine; Colon, Sigmoid; Constipation; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Enteric Nervous System; Female; Ganglionic Stimulants; Gastrointestinal Transit; Humans; In Vitro Techniques; Kinetics; Middle Aged; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Neurokinin A; Nicotinic Agonists; Prostaglandin-Endoperoxide Synthases; Receptors, Neurokinin-1; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; Substance P; Tetrodotoxin; Young Adult | 2009 |
HCl-activated neural and epithelial vanilloid receptors (TRPV1) in cat esophageal mucosa.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cats; Diterpenes; Electric Stimulation; Epithelial Cells; Esophagus; Hydrochloric Acid; In Vitro Techniques; Male; Mucous Membrane; Muscle Contraction; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Stimulation, Chemical; Submucous Plexus; Substance P; Tetrodotoxin; TRPV Cation Channels | 2009 |
In vitro characterization of the effects of rat/mouse hemokinin-1 on mouse colonic contractile activity: a comparison with substance P.
Topics: Animals; Colon; Mice; Muscle Contraction; Neurotransmitter Agents; Nitric Oxide; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tachykinins | 2009 |
Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon.
Topics: Animals; Atropine; Capsaicin; Colon; Dose-Response Relationship, Drug; Gastrointestinal Motility; Immunohistochemistry; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Neurokinin A; Pyrazines; Pyridines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Rectum; Substance P; Tetrodotoxin; Time Factors; TRPV Cation Channels; Ubiquitin Thiolesterase | 2009 |
Age-related changes in functional NANC innervation with VIP and substance P in the jejunum of Lewis rats.
Topics: Aging; Animals; Electric Stimulation; Enteric Nervous System; Excitatory Postsynaptic Potentials; Gastrointestinal Motility; Inhibitory Postsynaptic Potentials; Jejunum; Male; Muscle Contraction; Muscle, Smooth; Neuronal Plasticity; Rats; Rats, Inbred Lew; Substance P; Synaptic Transmission; Vasoactive Intestinal Peptide | 2009 |
Proteinase-activated receptor-2 activation evokes oesophageal longitudinal smooth muscle contraction via a capsaicin-sensitive and neurokinin-2 receptor-dependent pathway.
Topics: Animals; Axons; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Esophagus; Female; Immunohistochemistry; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Opossums; Peptide Fragments; Receptor, PAR-2; Receptors, Neurokinin-2; Signal Transduction; Substance P; Trypsin | 2010 |
Pancreatic polypeptide enhances colonic muscle contraction and fecal output through neuropeptide Y Y4 receptor in mice.
Topics: Acetylcholine; Animals; Atropine; Colon; Feces; Gene Expression Regulation; Gene Knockout Techniques; Ileum; In Vitro Techniques; Intestinal Mucosa; Intestines; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Pancreatic Polypeptide; Receptors, Neuropeptide Y; Substance P; Water | 2010 |
Postnatal maturation of the gastrointestinal tract: a functional and immunohistochemical study in the guinea-pig ileum at weaning.
Topics: Acetylcholine; Animals; Arachidonic Acids; Benzoxazines; Calbindin 2; Calbindins; Cholinergic Agonists; Electric Stimulation; Endocannabinoids; Female; Guinea Pigs; Ileum; Immunohistochemistry; Morphine; Morpholines; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Naphthalenes; Narcotic Antagonists; Neurofilament Proteins; Neurons; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Receptors, Opioid; S100 Calcium Binding Protein G; Substance P; Weaning | 2009 |
Contractile responses induced by physalaemin, an analogue of substance P, in the rat esophagus.
Topics: Animals; Atropine; Esophagus; Male; Mucous Membrane; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Muscle, Striated; Nifedipine; Physalaemin; Rats; Rats, Wistar; Receptors, Tachykinin; Substance P; Tetrodotoxin | 2010 |
Augmentation of the ascending component of the peristaltic reflex and substance P release by glial cell line-derived neurotrophic factor.
Topics: Animals; Colon; Glial Cell Line-Derived Neurotrophic Factor; Intestinal Mucosa; Intestines; Mice; Mice, Knockout; Muscle Contraction; Neurotransmitter Agents; Peristalsis; Rats; Reflex; Substance P | 2010 |
Substance P activates both contractile and inflammatory pathways in lymphatics through the neurokinin receptors NK1R and NK3R.
Topics: Animals; Cells, Cultured; Inflammation; Lymphatic Vessels; Male; Mitogen-Activated Protein Kinase 3; Muscle Contraction; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myosin Light Chains; Neurotransmitter Agents; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Signal Transduction; Substance P | 2011 |
[The effect of central histamine H3 receptor on breathing activity of asthmatic guinea pigs].
Topics: Animals; Asthma; Brain; Guinea Pigs; Histamine Agonists; Histamine H3 Antagonists; Lateral Ventricles; Male; Methylhistamines; Muscle Contraction; Piperidines; Receptors, Histamine H3; Substance P; Trachea | 2006 |
Activation-dependent descending reflex evacuation motority of anal canal in rat model.
Topics: Afferent Pathways; Anal Canal; Anesthetics, Local; Animals; Atropine; Biophysics; Catheterization; Choline O-Acetyltransferase; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; In Vitro Techniques; Male; Models, Animal; Muscle Contraction; NADPH Dehydrogenase; Nitroarginine; Parasympatholytics; Rats; Rectum; Reflex; Substance P; Tetrodotoxin | 2010 |
NK receptors, Substance P, Ano1 expression and ultrastructural features of the muscle coat in Cav-1(-/-) mouse ileum.
Topics: Animals; Anoctamin-1; Caveolae; Caveolin 1; Chloride Channels; Gastrointestinal Motility; Ileum; Immunohistochemistry; Interstitial Cells of Cajal; Mice; Mice, Knockout; Microscopy, Electron, Transmission; Mitochondria, Muscle; Muscle Contraction; Myocytes, Smooth Muscle; Neurons; Proto-Oncogene Proteins c-kit; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Signal Transduction; Substance P | 2011 |
Transient receptor potential ankyrin 1 is expressed by inhibitory motoneurons of the mouse intestine.
Topics: Acrolein; Aldehydes; Animals; Carbachol; Cecum; Colon; Duodenum; Epithelial Cells; Female; Fluorescent Antibody Technique; Ganglia; Gastric Emptying; Gastric Mucosa; Gastrointestinal Motility; Ileum; Interneurons; Intestinal Mucosa; Isothiocyanates; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Neurons; Muscle Contraction; Muscle, Smooth; Neurons, Afferent; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stomach; Substance P; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2011 |
Gi-coupled γ-aminobutyric acid-B receptors cross-regulate phospholipase C and calcium in airway smooth muscle.
Topics: Baclofen; Bradykinin; Calcium; Cells, Cultured; GABA-A Receptor Agonists; GABA-B Receptor Agonists; Humans; Inositol Phosphates; Lung; Muscimol; Muscle Contraction; Muscle, Smooth; Myocytes, Smooth Muscle; Receptors, GABA-A; Receptors, GABA-B; Substance P; Type C Phospholipases; Xanthenes | 2011 |
Influence of influenza A infection on capsaicin-induced responses in murine airways.
Topics: Animals; Biphenyl Compounds; Bronchoalveolar Lavage Fluid; Capsaicin; Carbachol; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Inflammation; Influenza A virus; Isoproterenol; Leukocytes; Male; Mice; Mice, Inbred BALB C; Models, Biological; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Orthomyxoviridae Infections; Piperidines; Prostaglandin Antagonists; Respiratory Mucosa; Specific Pathogen-Free Organisms; Substance P; Trachea; TRPV Cation Channels; Xanthones | 2012 |
Isometric responses of isolated intrapulmonary bronchioles from cats with and without adult heartworm infection.
Topics: Acetylcholine; Animals; Bronchioles; Bronchodilator Agents; Cat Diseases; Cats; Dirofilaria immitis; Dirofilariasis; Histamine; In Vitro Techniques; Isoproterenol; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Myography; Nitroprusside; Serotonin; Serotonin Receptor Agonists; Substance P | 2012 |
In vitro and in vivo pharmacological characterization of the novel NK₁ receptor selective antagonist Netupitant.
Topics: Analysis of Variance; Animals; Atropine; Calcium Signaling; Carbachol; CHO Cells; Cholinergic Agonists; Cricetinae; Dose-Response Relationship, Drug; Female; Gerbillinae; Guinea Pigs; HEK293 Cells; Humans; Ileum; In Vitro Techniques; Injections, Intraperitoneal; Injections, Spinal; Male; Mice; Muscarinic Antagonists; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Nociception; Protein Binding; Pyridines; Rats; Receptors, Neurokinin-1; Substance P | 2012 |
Brain-derived neurotrophic factor enhances the contraction of intestinal muscle strips induced by SP and CGRP in mice.
Topics: Acetylcholine; Animals; Brain-Derived Neurotrophic Factor; Calcitonin Gene-Related Peptide; Colon; Gastrointestinal Motility; Ileum; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle Contraction; Receptor, trkB; Substance P | 2012 |
Role of tachykinins and neurokinin receptor subtypes in the regulation of motility of the forestomach and abomasum in conscious sheep.
Topics: Abomasum; Animals; Benzamides; Gastrointestinal Motility; Injections, Intravenous; Kinetics; Male; Muscle Contraction; Neurokinin A; Omasum; Piperidines; Receptors, Neurokinin-2; Rumen; Sheep; Substance P; Tachykinins; Tryptophan | 2013 |
The early effects of partial outflow obstruction on contractile properties of diabetic and non-diabetic rat bladder.
Topics: Adenosine Triphosphate; Animals; Carbachol; Diabetes Mellitus, Experimental; Electric Stimulation; Female; Muscle Contraction; Muscle, Smooth; Rats; Substance P; Urinary Bladder; Urinary Bladder Neck Obstruction | 2002 |
Stimulation of peripheral nociceptor endings by low dose morphine and its signaling mechanism.
Topics: Analgesics, Opioid; Animals; Calcium; Dose-Response Relationship, Drug; GTP-Binding Proteins; Hindlimb; Male; Mice; Morphine; Muscle Contraction; Nociceptors; Pertussis Toxin; Receptors, Opioid, mu; Signal Transduction; Substance P | 2002 |
Possible role of bioactive peptides in the regulation of human detrusor smooth muscle - functional effects in vitro and immunohistochemical presence.
Topics: Atrial Natriuretic Factor; Calcitonin Gene-Related Peptide; Endothelin-1; Female; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Peptides; Substance P; Urinary Bladder; Urinary Bladder Diseases; Vasoactive Intestinal Peptide | 2002 |
Immune-mediated neural dysfunction in a murine model of chronic Helicobacter pylori infection.
Topics: Acetylcholine; Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Enteric Nervous System; Female; Gastritis; Helicobacter Infections; Helicobacter pylori; Immunohistochemistry; Macrophages; Mice; Mice, Inbred BALB C; Mice, SCID; Muscle Contraction; Specific Pathogen-Free Organisms; Spinal Cord; Stomach; Substance P; Vasoactive Intestinal Peptide | 2002 |
Interleukin-1beta-induced airway hyperresponsiveness enhances substance P in intrinsic neurons of ferret airway.
Topics: Acetylcholine; Animals; Bronchial Hyperreactivity; Disease Models, Animal; Electric Stimulation; Ferrets; Instillation, Drug; Interleukin-1; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Neurons; Substance P; Trachea | 2002 |
The mechanisms for tachykinin-induced contractions of the rabbit corpus cavernosum.
Topics: Animals; Benzamides; Calcium; Dose-Response Relationship, Drug; Glycopeptides; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Penis; Permeability; Piperidines; Quinuclidines; Rabbits; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins; Type C Phospholipases | 2002 |
Modulatory role of tachykinin NK1 receptor in cholinergic contraction of mouse trachea.
Topics: Animals; Atropine; Chromatography, High Pressure Liquid; Electric Stimulation; Mice; Mice, Knockout; Muscle Contraction; Parasympathetic Nervous System; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Stereoisomerism; Substance P; Synaptic Transmission; Tetrodotoxin; Trachea | 2003 |
Substance P via NK1 receptor facilitates hyperactive bladder afferent signaling via action of ROS.
Topics: Animals; Benzamides; Biphenyl Compounds; Cell Adhesion Molecules; Dose-Response Relationship, Drug; Drug Administration Routes; Electric Stimulation; Female; Free Radical Scavengers; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Pelvis; Piperidines; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Neurokinin-1; Reflex, Abnormal; Signal Transduction; Sodium Chloride; Substance P; Superoxide Dismutase; Urinary Bladder; Urinary Bladder, Neurogenic; Urination; Visceral Afferents | 2003 |
Mechanisms involved in the loss of excitatory post-stimulus responses by inflammation.
Topics: Adenosine Triphosphate; Animals; Colitis; Cyclooxygenase Inhibitors; Electric Stimulation; Female; In Vitro Techniques; Indomethacin; Male; Methiothepin; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Purinergic P2 Receptor Antagonists; Quinuclidines; Rabbits; Serotonin Antagonists; Substance P; Suramin; Trinitrobenzenesulfonic Acid | 2003 |
Inhibitory effects of botulinum toxin on pyloric and antral smooth muscle.
Topics: Acetylcholine; Animals; Atropine; Botulinum Toxins, Type A; Electric Stimulation; Guinea Pigs; Kinetics; Muscle Contraction; Muscle, Smooth; Pyloric Antrum; Pylorus; Substance P; Tetrodotoxin | 2003 |
Ca2+-recruitment in tachykinin-induced contractions of gut smooth muscle from African clawed frog, Xenopus laevis and rainbow trout, Oncorhynchus mykiss.
Topics: Animals; Calcium Signaling; Enzyme Inhibitors; Gastric Mucosa; In Vitro Techniques; Intestinal Mucosa; Intestines; Muscle Contraction; Muscle, Smooth; Oncorhynchus mykiss; Signal Transduction; Stomach; Substance P; Tetrodotoxin; Thapsigargin; Xenopus laevis | 2003 |
Substance P released from intrinsic airway neurons contributes to ozone-enhanced airway hyperresponsiveness in ferret trachea.
Topics: Animals; Capsaicin; Electric Stimulation; Female; Ferrets; Ganglia; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Neurons; Ozone; Piperidines; Substance P; Trachea | 2003 |
PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors.
Topics: Animals; Benzamides; Capsaicin; Female; Intestine, Small; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Oligopeptides; Piperidines; Quinuclidines; Receptor, PAR-2; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Thrombin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Tetrodotoxin; Trypsin | 2003 |
Experimental study of the effect of capsaicin on the urinary bladder function in rats.
Topics: Administration, Intravesical; Animals; Capsaicin; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Wistar; Substance P; Urinary Bladder; Urination | 2000 |
Dependence of IL-4, IL-13, and nematode-induced alterations in murine small intestinal smooth muscle contractility on Stat6 and enteric nerves.
Topics: Acetylcholine; Animals; Antibodies, Monoclonal; Drug Administration Schedule; Electric Stimulation; Enteric Nervous System; Female; In Vitro Techniques; Injections, Intravenous; Interleukin-13; Interleukin-4; Jejunum; Mice; Mice, Inbred BALB C; Mice, Knockout; Muscle Contraction; Muscle, Smooth; Nematospiroides dubius; Nippostrongylus; Recombinant Proteins; Signal Transduction; STAT6 Transcription Factor; Strongylida Infections; Substance P; Trans-Activators | 2003 |
Tachykinins mediate non-adrenergic, non-cholinergic excitatory neurotransmission to the hamster ileum via NK1 and NK2 receptors.
Topics: Animals; Autonomic Agents; Benzamides; Cricetinae; Dose-Response Relationship, Drug; Electric Stimulation; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neuromuscular Junction; NG-Nitroarginine Methyl Ester; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Synaptic Transmission; Tryptophan | 2003 |
Contribution of tachykinin receptor subtypes to micturition reflex in guinea pigs.
Topics: Animals; Brain; Catheterization; CHO Cells; Cricetinae; Dipeptides; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Indoles; Injections, Intravenous; Iodine Radioisotopes; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Piperidines; Radioligand Assay; Receptors, Neurokinin-1; Spinal Cord; Substance P; Succinimides; Tetrazoles; Tissue Extracts; Transfection; Urinary Bladder; Urination | 2003 |
Altered contractile responsiveness in ileal longitudinal muscle after total gastrectomy in a rat model.
Topics: Animals; Carbachol; Gastrectomy; Ileum; Ilium; Male; Muscle Contraction; Muscle, Smooth; Postgastrectomy Syndromes; Potassium Chloride; Rats; Rats, Wistar; Serotonin; Substance P | 2004 |
Modulation of autonomous contractile activity in the isolated whole bladder of the guinea pig.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Autonomic Nervous System; Female; Guinea Pigs; Muscle Contraction; Substance P; Urinary Bladder | 2004 |
Effects of clonidine and tricyclic antidepressants on gastric smooth muscle contractility.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Antidepressive Agents, Tricyclic; Clonidine; Electric Stimulation; Gastrointestinal Motility; Guinea Pigs; Muscle Contraction; Muscle, Smooth; Organ Culture Techniques; Stomach; Substance P | 2004 |
The role of calcium channels in substance P-induced contractile response in the rat iris.
Topics: Amiloride; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Econazole; In Vitro Techniques; Iris; Male; Muscle Contraction; Nicardipine; Rats; Rats, Wistar; Ruthenium Red; Substance P | 2003 |
Motor responses of rat hypertrophic intestine following chronic obstruction.
Topics: Acetylcholine; Animals; Chronic Disease; Electric Stimulation; Female; Gastrointestinal Motility; Hypertrophy; Intestinal Obstruction; Intestines; Muscle Contraction; Muscle, Smooth; Organ Culture Techniques; Rats; Rats, Wistar; Substance P | 2004 |
Endothelium-dependent responses in small human mesenteric arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Biological Factors; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Histamine; Humans; In Vitro Techniques; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Potassium; Potassium Channels; Splanchnic Circulation; Substance P | 2004 |
Mechanisms determining cholinergic neural responses in airways of young and mature rabbits.
Topics: Acetylcholine; Acetylcholinesterase; Aging; Animals; Autonomic Nervous System; Bronchoconstrictor Agents; Choline O-Acetyltransferase; Electric Stimulation; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Nerve Growth Factors; Rabbits; Receptor, Muscarinic M2; Receptors, Cholinergic; Respiratory Mechanics; Substance P; Trachea | 2004 |
Characterization of receptors for two Xenopus gastrointestinal tachykinin peptides in their species of origin.
Topics: Animals; Binding Sites; Cardia; Dose-Response Relationship, Drug; Eledoisin; Female; Indoles; Intercellular Signaling Peptides and Proteins; Intestine, Small; Iodine Radioisotopes; Isoindoles; Kassinin; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Physalaemin; Receptors, Tachykinin; Species Specificity; Substance P; Xenopus | 2004 |
Mechanisms of neurokinin A- and substance P-induced contractions in rat detrusor smooth muscle in vitro.
Topics: Amides; Animals; Male; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Neurokinin A; Pyridines; Rats; Rats, Wistar; Substance P; Urinary Bladder | 2004 |
Inhibitory actions of calcitonin gene-related peptide and capsaicin: evidence for local axonal reflexes in the bladder wall.
Topics: Action Potentials; Animals; Axons; Calcitonin Gene-Related Peptide; Capsaicin; Female; Guinea Pigs; In Vitro Techniques; Muscarinic Agonists; Muscle Contraction; Neurons, Afferent; Nicotinic Agonists; Reflex; Substance P; Urinary Bladder | 2005 |
Substance P and vasoactive intestinal peptide in rat small-bowel isografts.
Topics: Animals; Enteric Nervous System; Gastrointestinal Agents; Gastrointestinal Motility; In Vitro Techniques; Jejunum; Male; Muscle Contraction; Rats; Rats, Inbred Lew; Substance P; Tetrodotoxin; Transplantation, Isogeneic; Vasoactive Intestinal Peptide | 2005 |
Functional characterisation of tachykinin receptors in the circular muscle layer of the mouse ileum.
Topics: Action Potentials; Analgesics; Animals; Antipsychotic Agents; Atropine; Electric Stimulation; Ileum; Indoles; Isoindoles; Mice; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Neurons; Nitroarginine; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 2005 |
Involvement of Ca2+ signaling in tachykinin-mediated contractile responses in swine trachea.
Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Carbachol; Cytosol; Dose-Response Relationship, Drug; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Substance P; Swine; Tachykinins; Trachea | 2005 |
Role of endothelium and nitric oxide in modulating in vitro responses of colonic arterial and venous rings to vasodilatory neuropeptides in horses.
Topics: Acetylcholine; Animals; Arteries; Calcitonin Gene-Related Peptide; Colon; Dose-Response Relationship, Drug; Endothelium, Vascular; Horses; In Vitro Techniques; Muscle Contraction; Neuropeptides; Nitric Oxide; Norepinephrine; Substance P; Vasoactive Intestinal Peptide; Vasodilator Agents; Veins | 2005 |
A neuroactive steroid, allotetrahydrocorticosterone inhibits sensory nerves activation in guinea-pig airways.
Topics: Animals; Bronchi; Corticosterone; Dose-Response Relationship, Drug; Electric Stimulation; Ganglionic Stimulants; Guinea Pigs; Muscle Contraction; Muscle, Smooth; Neurons, Afferent; Organ Culture Techniques; Potassium Channels, Voltage-Gated; Quaternary Ammonium Compounds; Substance P | 2005 |
Endogenous cannabinoid receptor agonists inhibit neurogenic inflammations in guinea pig airways.
Topics: Amides; Animals; Arachidonic Acids; Bronchi; Bronchoconstriction; Calcium Channel Blockers; Camphanes; Cannabinoid Receptor Agonists; Capsaicin; Electric Stimulation; Endocannabinoids; Ethanolamines; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth; Nerve Fibers, Unmyelinated; Neurogenic Inflammation; Organ Culture Techniques; Palmitic Acids; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Substance P | 2005 |
Regional differences in gastrointestinal motility disturbances during acute necrotising pancreatitis.
Topics: Acute Disease; Animals; Carbachol; Choline Deficiency; Dietary Supplements; Dinoprost; Disease Models, Animal; Ethionine; Female; Gastric Emptying; Gastrointestinal Motility; In Vitro Techniques; Mice; Muscle Contraction; Muscle, Smooth; Pancreatitis, Acute Necrotizing; Substance P | 2005 |
Effect of erythromycin on gastric dysmotility and neuroendocrine peptides in rats with diabetes mellitus.
Topics: Animals; Diabetes Mellitus, Experimental; Erythromycin; Gastrointestinal Agents; Gastrointestinal Motility; Male; Motilin; Muscle Contraction; Muscle, Smooth; Pyloric Antrum; Rats; Rats, Sprague-Dawley; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 2005 |
Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aged; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Case-Control Studies; Colon; Diverticulum; Endocannabinoids; Female; Glycerides; Humans; Imidazoles; Isoproterenol; Male; Middle Aged; Morpholines; Muscle Contraction; Muscle, Smooth; Naphthalenes; Neurokinin-1 Receptor Antagonists; Piperidines; Polyunsaturated Alkamides; Propanolamines; Pyrazoles; Quinuclidines; Rimonabant; Substance P; Tetrodotoxin | 2006 |
Epithelium-dependent and -independent inhibitory effects of sivelestat, a neutrophil elastase inhibitor, on substance P-induced contraction of airway smooth muscle in lipopolysaccharide-treated guinea-pigs.
Topics: Animals; Bronchi; Glycine; Guinea Pigs; In Vitro Techniques; Indomethacin; Leukocyte Elastase; Lipopolysaccharides; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Potassium Chloride; Prostaglandins; Respiratory Mucosa; Respiratory System; Serine Proteinase Inhibitors; Substance P; Sulfonamides; Tachykinins; Trachea | 2005 |
Nerve growth factor-enhanced airway responsiveness involves substance P in ferret intrinsic airway neurons.
Topics: Animals; Electric Stimulation; Female; Ferrets; Ganglia; Muscle Contraction; Muscle, Smooth; Nerve Growth Factor; Neurons; Organ Culture Techniques; Substance P; Trachea | 2006 |
The role of tachykinins in circular muscle contractility of the murine ileum: a functional investigation.
Topics: Animals; Atropine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Ilium; In Vitro Techniques; Male; Mice; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Nitroarginine; Peptide Fragments; Potassium Chloride; Pyrrolidonecarboxylic Acid; Substance P; Tachykinins; Tetrodotoxin | 2006 |
Alterations in intestinal contractility during inflammation are caused by both smooth muscle damage and specific receptor-mediated mechanisms.
Topics: Acetylcholine; Animals; Electric Stimulation; Gastrointestinal Motility; In Vitro Techniques; Inflammation; Intestine, Small; Male; Muscle Contraction; Muscle, Smooth; Neurotransmitter Agents; Potassium Chloride; Rats; Rats, Sprague-Dawley; Substance P; Trichinella spiralis; Trichinellosis | 2006 |
A novel bronchial ring bioassay for the evaluation of small airway smooth muscle function in mice.
Topics: Animals; Biological Assay; Boron Compounds; Bronchi; Bronchoconstrictor Agents; Calcium Channel Blockers; Dose-Response Relationship, Drug; Imidazoles; In Vitro Techniques; Methacholine Chloride; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nifedipine; Papaverine; Potassium Chloride; Respiratory Mucosa; Ryanodine; Stress, Mechanical; Substance P; Vasodilator Agents | 2006 |
Altered neurogenic and mechanical responses to acetylcholine, ATP and substance P in detrusor from rat with outlet obstruction.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Atropine; Cholinergic Agonists; Cyclooxygenase Inhibitors; Electric Stimulation; Female; In Vitro Techniques; Indomethacin; Mandelic Acids; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Rats; Rats, Sprague-Dawley; Substance P; Suramin; Urethra; Urinary Bladder; Urinary Bladder Neck Obstruction | 2006 |
5-HT4 receptor agonists enhance both cholinergic and nitrergic activities in human isolated colon circular muscle.
Topics: Acetylcholine; Adult; Aged; Aged, 80 and over; Benzofurans; Colon; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Female; Humans; Indoles; Male; Middle Aged; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Organ Culture Techniques; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Scopolamine; Serotonin 5-HT4 Receptor Agonists; Substance P | 2006 |
Fibre-free diet leads to impairment of neuronally mediated muscle contractile response in rat distal colon.
Topics: Animal Feed; Animals; Carbachol; Cell Count; Cholinergic Agonists; Colon; Dietary Fiber; Electric Stimulation; Enteric Nervous System; Enterochromaffin Cells; Immunohistochemistry; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Wistar; Serotonin; Substance P | 2006 |
Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetates; Acetylcholine; Albuterol; Animals; Atropine; Benzoquinones; Carbachol; Chromones; Cyclopropanes; Dinoprost; Drug Evaluation, Preclinical; Guinea Pigs; Heptanoic Acids; Histamine; In Vitro Techniques; Indoles; Indomethacin; Ketanserin; Ketotifen; Leukotriene Antagonists; Leukotriene D4; Male; Muscle Contraction; Muscle, Smooth; Phenylcarbamates; Powders; Procaterol; Prostaglandin Antagonists; Prostaglandin D2; Quinolines; Receptors, Thromboxane A2, Prostaglandin H2; Serotonin; Substance P; Sulfides; Sulfonamides; Tosyl Compounds; Trachea; Tryptophan | 2006 |
Paradoxical effect of salbutamol in a model of acute organophosphates intoxication in guinea pigs: role of substance P release.
Topics: Albuterol; Animals; Calcium; Cholinesterase Inhibitors; Colforsin; Diamines; Guinea Pigs; Lung; Male; Muscle Contraction; omega-Conotoxins; Parathion; Physostigmine; Pirenzepine; Plethysmography, Whole Body; Substance P; Tetrodotoxin; Tryptophan | 2007 |
Attenuation of contractile dysfunction by atorvastatin after intestinal ischemia reperfusion injury in rats.
Topics: Administration, Oral; Animals; Atorvastatin; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Glutathione; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ileum; In Vitro Techniques; Intestines; Male; Malondialdehyde; Muscle Contraction; Neurotransmitter Agents; Peroxidase; Potassium Chloride; Pyrroles; Rats; Rats, Wistar; Reperfusion Injury; Substance P | 2007 |
Effects of substance P on spontaneous contraction in the flexure region of the guinea pig colon.
Topics: Animals; Calcium Channel Blockers; Colon; Female; Guinea Pigs; Isotonic Solutions; Male; Models, Animal; Muscle Contraction; Muscle, Smooth; Receptors, Tachykinin; Substance P; Time Factors; Verapamil | 2007 |
Botulinum toxin type A inhibits rat pyloric myoelectrical activity and substance P release in vivo.
Topics: Animals; Botulinum Toxins, Type A; Electromyography; Female; Immunohistochemistry; Male; Muscle Contraction; Pyloric Antrum; Radioimmunoassay; Rats; Rats, Wistar; Substance P | 2007 |
Role of VIP and substance P in NANC innervation in the longitudinal smooth muscle of the rat jejunum - influence of extrinsic denervation.
Topics: Adrenergic Fibers; Animals; Cholinergic Fibers; Electric Stimulation; Gastrointestinal Motility; Jejunum; Male; Muscle Contraction; Muscle, Smooth; Nitroarginine; Organ Transplantation; Rats; Rats, Inbred Lew; Substance P; Synaptic Transmission; Vasoactive Intestinal Peptide | 2007 |
Intraluminal acid induces oesophageal shortening via capsaicin-sensitive neurokinin neurons.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Esophagus; Female; Gastric Acid; Male; Models, Biological; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurons, Afferent; Opossums; Peptide Fragments; Receptors, Neurokinin-2; Substance P; Tissue Culture Techniques | 2007 |
Role for NK(1) and NK(2) receptors in the motor activity in mouse colon.
Topics: Animals; Atropine; Colon; Electric Stimulation; Mice; Mice, Inbred C57BL; Muscarinic Antagonists; Muscle Contraction; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Sodium Channel Blockers; Substance P; Tetrodotoxin | 2007 |
Long-term effects of extrinsic denervation on VIP and substance P innervation in circular muscle of rat jejunum.
Topics: Animals; Denervation; In Vitro Techniques; Jejunum; Male; Muscle Contraction; Muscle, Smooth; Nitroarginine; Rats; Rats, Inbred Lew; Substance P; Vasoactive Intestinal Peptide | 2007 |
Pelviureteric peristaltic contractions in diabetic rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Diabetes Mellitus, Experimental; Humans; In Vitro Techniques; Kidney Pelvis; Male; Matched-Pair Analysis; Muscle Contraction; Muscle Strength; Muscle, Smooth; Neurokinin A; Neurotransmitter Agents; Peristalsis; Rats; Rats, Wistar; Sensory System Agents; Substance P; Ureter | 2007 |
Effect of chronic, extrinsic denervation on functional NANC innervation with vasoactive intestinal polypeptide and substance P in longitudinal muscle of rat jejunum.
Topics: Aging; Animals; Data Interpretation, Statistical; Denervation; Electric Stimulation; Enteric Nervous System; Immunohistochemistry; Intestine, Small; Jejunum; Male; Microscopy, Fluorescence; Muscle Contraction; Muscle, Smooth; Neurotransmitter Agents; Rats; Rats, Inbred Lew; Substance P; Tyrosine 3-Monooxygenase; Vasoactive Intestinal Peptide | 2008 |
Effects of extrinsic denervation on innervation with VIP and substance P in circular muscle of rat jejunum.
Topics: Animals; Denervation; Electric Stimulation; Enteric Nervous System; Humans; Jejunum; Male; Muscle Contraction; Rats; Rats, Inbred Lew; Substance P; Vasoactive Intestinal Peptide | 2008 |
Pupillary constriction by bradykinin and capsaicin: mode of action.
Topics: Animals; Bradykinin; Capsaicin; Female; In Vitro Techniques; Male; Miotics; Muscle Contraction; Pupil; Rabbits; Substance P; Tetrodotoxin | 1984 |
The response of the isolated iris sphincter muscle of various mammalian species to substance P.
Topics: Animals; Carbachol; Cats; Cattle; Dogs; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Iris; Muscle Contraction; Muscle, Smooth; Papio; Rabbits; Substance P; Swine; Tissue Preservation | 1984 |
Mechanisms of substance P-induced contraction of rabbit airway smooth muscle.
Topics: Animals; Atropine; Biomechanical Phenomena; Dose-Response Relationship, Drug; Ganglia, Parasympathetic; Hemicholinium 3; Hexamethonium; Hexamethonium Compounds; Methacholine Chloride; Methacholine Compounds; Muscle Contraction; Muscle, Smooth; Neostigmine; Nerve Block; Neural Inhibition; Rabbits; Substance P; Synaptic Transmission; Tetrodotoxin; Trachea | 1984 |
A smooth muscle excitatory material from the nerve of Remak of the chicken rectum.
Topics: Adenosine Triphosphate; Angiotensin II; Animals; Chickens; Chromatography, Gel; Female; Ganglia, Autonomic; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Weight; Muscle Contraction; Muscle, Smooth; Neurotransmitter Agents; Prostaglandins; Rectum; Serotonin; Substance P; Tissue Extracts | 1984 |
Synthesis of substance P analogs with arginine in position eleven.
Topics: Animals; Arginine; Chemical Phenomena; Chemistry; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Structure-Activity Relationship; Substance P | 1984 |
Pharmacological characterization of novel mammalian tachykinins, neurokinin alpha and neurokinin beta.
Topics: Animals; Chemical Phenomena; Chemistry; Duodenum; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Oligopeptides; Rats; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Vas Deferens | 1984 |
Contracture of guinea-pig ileum on withdrawal of methionine5-enkephalin is mediated by substance P.
Topics: Animals; Enkephalin, Methionine; Feedback; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Naloxone; Substance P; Substance Withdrawal Syndrome | 1983 |
Morphine does not antagonize the substance P mediated excitation of dorsal horn neurons.
Topics: Animals; Biological Assay; Blood Pressure; Cats; Evoked Potentials; Female; Guinea Pigs; Ileum; Male; Morphine; Muscle Contraction; Neurons; Rabbits; Serotonin; Spinal Cord; Substance P | 1980 |
3H-Labelling of substance P by tritium exchange and deshalogenation.
Topics: Animals; Biological Assay; Guinea Pigs; Ileum; Isotope Labeling; Muscle Contraction; Radioimmunoassay; Substance P; Tritium | 1980 |
Tachyphylaxis due to the D-Phe7 analogue of substance P.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Substance P; Tachyphylaxis | 1980 |
Caerulein, substance P, serotonin and cholinomimetics induce rhythmic contractions of the intestinal circular muscle.
Topics: Animals; Bethanechol Compounds; Bombesin; Ceruletide; Desensitization, Immunologic; Dimethylphenylpiperazinium Iodide; Enkephalins; Female; Gastrointestinal Motility; Guinea Pigs; Hexamethonium Compounds; Ileum; In Vitro Techniques; Male; Muscle Contraction; Norepinephrine; Parasympathomimetics; Peristalsis; Serotonin; Substance P; Tetrodotoxin; Tropicamide | 1980 |
Influence of cerebral ventricles perfusion with hexapeptide derivatives of substance P on evoked tongue jerks in rats.
Topics: Animals; Injections, Intraventricular; Male; Mechanoreceptors; Medulla Oblongata; Muscle Contraction; Rats; Reflex; Substance P; Tongue; Trigeminal Nerve | 1980 |
Substance P-induced autodesensitization inhibits atropine-resistant, neurotensin-stimulated contractions in guinea-pig ileum.
Topics: Animals; Atropine; Drug Resistance; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurotensin; Substance P | 1980 |
Excitatory and inhibitory effects of opiates in the rat vas deferens: a dual mechanism of opiate action.
Topics: Animals; Drug Interactions; Endorphins; Male; Morphine; Muscle Contraction; Naloxone; Narcotics; Rats; Receptors, Opioid; Stereoisomerism; Substance P; Vas Deferens | 1980 |
Substance P and neurotensin in the control of gastrointestinal function.
Topics: Animals; Digestive System Physiological Phenomena; Gastric Mucosa; Gastrointestinal Motility; Humans; Intestines; Muscle Contraction; Neurotensin; Substance P | 1980 |
Synthesis and contractile activity of the C-terminal heptapeptide of substance P with N5-dimethyl glutamine in the 6-position. Active site studies.
Topics: Amino Acid Sequence; Animals; Biological Assay; Guinea Pigs; Ileum; Muscle Contraction; Peptide Fragments; Structure-Activity Relationship; Substance P | 1980 |
Effect of cholecystokinin-octapeptide on opossum lower esophageal sphincter.
Topics: Animals; Atropine; Bethanechol Compounds; Cholecystokinin; Deglutition; Esophagogastric Junction; Muscle Contraction; Muscle, Smooth; Opossums; Pentagastrin; Phentolamine; Pressure; Pyrilamine; Substance P; Tetrodotoxin | 1980 |
Substance P and analogues: biological activity and degradation.
Topics: Animals; Biological Assay; Central Nervous System; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Neurotransmitter Agents; Rats; Receptors, Cell Surface; Structure-Activity Relationship; Substance P; Synaptosomes | 1980 |
Effect of some vasoactive peptides on the lower esophageal sphincter.
Topics: Angiotensin II; Animals; Bradykinin; Esophagogastric Junction; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurotensin; Peptides; Rats; Substance P; Vasopressins | 1980 |
The effect of indomethacin and adenosine 5'-triphosphate on the excitatory innervation of the rate urinary bladder.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Electric Stimulation; Indomethacin; Muscle Contraction; Naloxone; Rats; Substance P; Urinary Bladder | 1980 |
Peptide-containing neurons intrinsic to the gut wall. An experimental study in the pig.
Topics: Animals; Enkephalins; Jejunum; Muscle Contraction; Muscle, Smooth; Nerve Fibers; Peptides; Somatostatin; Substance P; Swine; Vasoactive Intestinal Peptide | 1981 |
Evidence that the action of cholecystokinin octapeptide on the guinea pig ileum longitudinal muscle is mediated in part by substance P release from the myenteric plexus.
Topics: Acetylcholine; Animals; Atropine; Cholecystokinin; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Sincalide; Substance P | 1981 |
Contracting activity of C-terminal fragments and a C-terminal hexapeptide analogue of substance P on non-stimulated and electrically stimulated isolated guinea-pig ileum.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Intestines; Muscle Contraction; Peptide Fragments; Substance P | 1981 |
Substance P, bethanechol, 4-aminopyridine, and potassium antagonize the depressing effects of low-frequency stimulation, tetrodotoxin, procaine, and of magnesium on the field-stimulated guinea-pig vas deferens.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Bethanechol Compounds; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Magnesium; Male; Muscle Contraction; Muscle, Smooth; Potassium; Procaine; Substance P; Tetrodotoxin; Vas Deferens | 1980 |
Nerves containing substance P, vasoactive intestinal polypeptide, enkephalin or somatostatin in the guinea-pig taenia coli. Distribution, ultrastructure and possible functions.
Topics: Animals; Colon; Endorphins; Enkephalins; Gastrointestinal Hormones; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Nerve Fibers; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 1981 |
Immunoreactive substance P in the chicken gut: distribution, development and possible functional significance.
Topics: Animals; Cecum; Chickens; Digestive System; Endocrine Glands; Muscle Contraction; Muscle, Smooth; Nerve Fibers; Proventriculus; Substance P | 1981 |
Distinct classes of substance P receptors revealed by a comparison of the activities of substance P and some of its segments.
Topics: Animals; Cattle; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; Muscle Contraction; Muscle, Smooth; Oligopeptides; Peptide Fragments; Pupil; Rats; Receptors, Cell Surface; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P; Urinary Bladder | 1981 |
The contractile effect of bombesin on the rat isolated urinary bladder.
Topics: Animals; Bombesin; Bradykinin; Carbachol; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Male; Muscle Contraction; Peptides; Rats; Substance P; Urinary Bladder | 1981 |
Neurotensin-induced contractions in venous smooth muscle.
Topics: Angiotensin II; Animals; Bradykinin; Dose-Response Relationship, Drug; Female; Male; Muscle Contraction; Muscle, Smooth, Vascular; Neurotensin; Norepinephrine; Portal Vein; Rats; Substance P | 1980 |
Regional differences in the response to substance P on the longitudinal muscle and the concentration of substance P in the digestive tract of the guinea-pig.
Topics: Animals; Atropine; Colon; Digestive System; Digestive System Physiological Phenomena; Esophagus; Guinea Pigs; Intestine, Small; Muscle Contraction; Muscle, Smooth; Organ Specificity; Radioimmunoassay; Rectum; Stomach; Substance P; Tissue Distribution | 1981 |
Contractile response of longitudinal and circular smooth muscles of guinea pig stomach and ileum to substance P.
Topics: Animals; Female; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Stomach; Substance P | 1981 |
Release of histamine by substance P.
Topics: Animals; Hindlimb; Histamine Release; In Vitro Techniques; Male; Mast Cells; Muscle Contraction; Nerve Endings; Rats; Rats, Inbred Strains; Serotonin; Skin; Substance P | 1981 |
Effect of L-prolyl-L-leucyl-glycinamide (MIF-I) on some neutrotransmitter-receptor interactions.
Topics: Acetylcholine; Animals; Behavior, Animal; Brain; Dopamine; Female; gamma-Aminobutyric Acid; Guinea Pigs; Histamine; Ileum; Male; Mice; Motor Activity; MSH Release-Inhibiting Hormone; Muscle Contraction; Norepinephrine; Rats; Serotonin; Substance P; Vas Deferens | 1981 |
Peptides and the human colon: an in vitro pharmacological study.
Topics: Colon; Dose-Response Relationship, Drug; Female; Gastrointestinal Motility; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Peptides; Specimen Handling; Substance P | 1981 |
The effect of indomethacin and substance P on the guinea pig urinary bladder.
Topics: Animals; Atropine; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle, Smooth; Substance P; Urinary Bladder | 1981 |
A specific substance P antagonist blocks smooth muscle contractions induced by non-cholinergic, non-adrenergic nerve stimulation.
Topics: Animals; Electric Stimulation; Eledoisin; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Physalaemin; Rabbits; Substance P | 1981 |
Biological activity of substance P methyl ester.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Salivation; Substance P | 1981 |
Substance P-immunoreactive nerve fibres in the anterior segment of the rabbit eye. Distribution and possible physiological significance.
Topics: Animals; Atropine; Electric Stimulation; Eye; Fluorescent Antibody Technique; Iris; Muscle Contraction; Muscle, Smooth; Neurons; Optic Nerve; Rabbits; Substance P | 1982 |
Antagonists of substance P.
Topics: Amino Acid Sequence; Animals; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Rabbits; Substance P | 1982 |
Indirect evidence for the inhibition of enteric substance P neurones by opiate agonists but not by capsaicin.
Topics: Animals; Capsaicin; Electric Stimulation; Fatty Acids, Unsaturated; Female; Guinea Pigs; In Vitro Techniques; Intestines; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotics; Neurons; Substance P; Synaptic Transmission | 1982 |
Synthesis and metabolic stability of a tritium-labelled substance P analogue.
Topics: Animals; Biological Assay; Cross Reactions; Drug Stability; Guinea Pigs; Ileum; Muscle Contraction; Peptide Fragments; Pyrrolidonecarboxylic Acid; Radioimmunoassay; Radioisotope Dilution Technique; Substance P; Tritium | 1982 |
Histamine H2-receptors on guinea-pig ileum myenteric plexus neurons mediate the release of contractile agents.
Topics: Animals; Dimaprit; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myenteric Plexus; Neurons; Neurotransmitter Agents; Receptors, Histamine; Receptors, Histamine H2; Serotonin; Substance P; Thiourea | 1982 |
Noncholinergic, nonadrenergic contraction and substance P in rabbit iris sphincter muscle.
Topics: Acetylcholine; Animals; Baclofen; Capsaicin; Cold Temperature; Electric Stimulation; Female; In Vitro Techniques; Iris; Male; Muscle Contraction; Rabbits; Reserpine; Substance P; Sympathectomy | 1981 |
Pharmacological characterization of the autonomous innervation of the guinea pig tracheobronchial smooth muscle.
Topics: Animals; Atropine; Autonomic Nervous System; Bronchi; Electric Stimulation; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth; Substance P; Sympatholytics; Trachea; Vasoactive Intestinal Peptide | 1981 |
Innervation of the muscularis mucosa in the canine stomach and colon.
Topics: Animals; Colon; Dogs; Muscle Contraction; Muscle, Smooth; Neurotensin; Stimulation, Chemical; Stomach; Substance P; Vasoactive Intestinal Peptide | 1982 |
Effects of opioids on noncholinergic excitatory responses of the guinea-pig isolated ileum: inhibition of release of enteric substance P.
Topics: Animals; Electric Stimulation; Endorphins; Guinea Pigs; Hexamethonium; Hexamethonium Compounds; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Substance P | 1982 |
The possible existence of multiple receptors for substance P.
Topics: Animals; Binding Sites; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Rats; Receptors, Cell Surface; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P; Tachyphylaxis; Vas Deferens | 1982 |
Action of substance P and its natural analogs on the circular muscle of the guinea pig ileum.
Topics: Animals; Atropine; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; Muscle Contraction; Muscle, Smooth; Peptides; Substance P; Tachykinins | 1981 |
Substance P in tumors: pheochromocytoma and carcinoid.
Topics: Adrenal Gland Neoplasms; Animals; Biological Assay; Blood Pressure; Carcinoid Tumor; Catecholamines; Cecal Neoplasms; Chromaffin Granules; Chromatography, High Pressure Liquid; Female; Guinea Pigs; Humans; Male; Muscle Contraction; Pheochromocytoma; Rabbits; Rats; Somatostatin; Substance P | 1981 |
Oxygen dependence of contractions in esophageal and gastric pyloric and ileocecal muscle of opossums.
Topics: Animals; Carbachol; Digestive System Physiological Phenomena; Esophagogastric Junction; Esophagus; Female; Gastric Fundus; Histamine; Ileocecal Valve; Male; Muscle Contraction; Muscle, Smooth; Opossums; Oxygen; Pylorus; Substance P | 1982 |
Contractile effects of some polypeptides on the isolated urinary bladder of guinea-pig, rabbit, and rat.
Topics: Animals; Eledoisin; Female; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Peptides; Rabbits; Rats; Rats, Inbred Strains; Somatostatin; Species Specificity; Substance P; Tetrodotoxin; Urinary Bladder | 1982 |
Agonist effects of [D-Pro2,D-Phe7,D-Trp9]substance P--evidence for different receptors.
Topics: Animals; Ganglia, Sympathetic; Guinea Pigs; Ileum; In Vitro Techniques; Jugular Veins; Male; Muscle Contraction; Rabbits; Rats; Receptors, Cell Surface; Receptors, Neurokinin-1; Substance P | 1982 |
Sensory neural mechanisms in contraction of the isolated sphincter pupillae: the role for substance P and the effects of sensory denervation on the responses to miotics.
Topics: Animals; Bradykinin; Capsaicin; Carbachol; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Iris; Male; Miotics; Muscle Contraction; Muscle Denervation; Muscle, Smooth; Rabbits; Substance P; Trigeminal Nerve | 1982 |
An enquiry into the mechanism by which substance P facilitates the phasic longitudinal contractions of the rabbit ileum.
Topics: Animals; Chlorides; Female; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Potassium; Rabbits; Substance P; Tetraethylammonium; Tetraethylammonium Compounds | 1982 |
Evidence that the contractile response of the guinea-pig ileum to capsaicin is due to substance P release.
Topics: Acetylcholine; Animals; Atropine; Capsaicin; Fatty Acids, Unsaturated; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Physostigmine; Substance P | 1982 |
Evaluation of (D-Pro2, D-Trp7,9)-substance P as an antagonist of substance P responses in the rat central nervous system.
Topics: Animals; Biological Assay; Guinea Pigs; Ileum; Male; Muscle Contraction; Neurons; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Trigeminal Caudal Nucleus; Trigeminal Nucleus, Spinal | 1982 |
[Differences in activity between substance P and substance P-heptapeptide as studied on the phenomenon of "gut dependence" in rats (author's transl)].
Topics: Animals; Humans; Ileum; In Vitro Techniques; Male; Morphine Dependence; Muscle Contraction; Muscle, Smooth; Naloxone; Peptide Fragments; Rats; Substance P | 1982 |
Use of substance P fragments to differentiate substance P receptors of different tissues.
Topics: Animals; Behavior, Animal; Cats; Female; Guinea Pigs; Ileum; Male; Mice; Muscle Contraction; Neurons; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Neurokinin-1; Salivation; Spinal Cord; Substance P | 1982 |
Fading and tachyphylaxis to the contractile effects of substance P in the guinea-pig ileum.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Narcotics; Parasympathomimetics; Peptide Hydrolases; Physalaemin; Substance P; Tachyphylaxis; Tetrodotoxin; Time Factors | 1982 |
Manifestations of gut opiate withdrawal contracture and its blockade by capsaicin.
Topics: Animals; Capsaicin; Digestive System; Electric Stimulation; Fatty Acids, Unsaturated; Guinea Pigs; Humans; Male; Muscle Contraction; Myenteric Plexus; Naloxone; Scopolamine; Serotonin; Serotonin Antagonists; Substance P; Substance Withdrawal Syndrome | 1982 |
Pharmacological effects of peptides on tracheal smooth muscle.
Topics: Animals; Carbachol; Female; Guinea Pigs; Histamine; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Peptides; Substance P; Trachea | 1982 |
Substance P antagonists active in vitro and in vivo.
Topics: Animals; Blood Pressure; Dogs; Guinea Pigs; Heart; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Rabbits; Rats; Substance P | 1982 |
Different contractile effects of substance P on the intestine of mammals.
Topics: Animals; Cats; Female; Guinea Pigs; Ileum; In Vitro Techniques; Intestines; Male; Muscle Contraction; Muscle, Smooth; Rabbits; Rats; Species Specificity; Substance P; Swine | 1982 |
Design and synthesis of effective antagonists of substance P.
Topics: Animals; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Peptides; Substance P | 1982 |
The involvement of substance P in the vagal control of the feline pylorus.
Topics: Acetylcholine; Animals; Blood Pressure; Cats; Gastrointestinal Motility; Muscle Contraction; Naloxone; Pylorus; Substance P; Vagus Nerve | 1982 |
Chemical neurotransmission--yesterday and today.
Topics: Acetylcholine; Animals; Atropine; Biological Evolution; Epinephrine; History, 19th Century; History, 20th Century; Humans; Male; Muscle Contraction; Neurochemistry; Neuromuscular Junction; Neurotransmitter Agents; Norepinephrine; Receptors, Adrenergic; Receptors, Cholinergic; Substance P; Sympathetic Nervous System; Synapses; Synaptic Transmission; Vas Deferens | 1982 |
Tritiated peptides. 12. Synthesis and biological activity of [4-3H-Phe8]substance P.
Topics: Amino Acids; Animals; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Cross Reactions; Guinea Pigs; Ileum; In Vitro Techniques; Isotope Labeling; Muscle Contraction; Muscle, Smooth; Substance P; Tritium | 1982 |
Structure-activity studies on the C-terminal amide of substance P.
Topics: Animals; Blood Pressure; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Rats; Structure-Activity Relationship; Substance P | 1982 |
Trigeminal nerve: the possible origin of substance p-nergic response in isolated rabbit iris sphincter muscle.
Topics: Animals; Bradykinin; Capsaicin; Carbachol; Electric Stimulation; Enkephalins; Female; In Vitro Techniques; Iris; Male; Muscle Contraction; Muscles; Rabbits; Somatostatin; Substance P; Trigeminal Nerve; Vasoactive Intestinal Peptide | 1982 |
Different action of substance P on gastric and ileal smooth muscle.
Topics: Animals; Dogs; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Stomach; Substance P | 1982 |
Neuronal substance P in the esophagus. Distribution and effects on motor activity.
Topics: Animals; Autonomic Nervous System; Cats; Electric Stimulation; Esophagus; Guinea Pigs; Motor Activity; Muscle Contraction; Muscle, Smooth; Nerve Fibers; Radioimmunoassay; Substance P; Swine | 1982 |
Electrical activity of longitudinal and circular muscle during peristalsis.
Topics: Action Potentials; Animals; Atropine; Chymotrypsin; Female; Gastrointestinal Motility; Guinea Pigs; Hexamethonium Compounds; In Vitro Techniques; Intestine, Small; Male; Muscle Contraction; Muscle, Smooth; Peristalsis; Pressure; Substance P; Tetrodotoxin | 1983 |
The mechanism of action of a substance P antagonist (D-Pro2, D-Trp7,9)-SP.
Topics: Animals; Atropine; Colon; Electric Stimulation; Guanethidine; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; p-Methoxy-N-methylphenethylamine; Substance P | 1982 |
Evidence that the contractile response of the guinea-pig ileum to capsaicin is due to release of substance P.
Topics: Animals; Atropine; Capsaicin; Endorphins; Fatty Acids, Unsaturated; Guanethidine; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Naloxone; Substance P | 1982 |
Responses of goat ruminal musculature to substance P in vitro and in vivo.
Topics: Animals; Dose-Response Relationship, Drug; Female; Gastrointestinal Motility; Goats; Heart Rate; In Vitro Techniques; Injections, Intravenous; Male; Muscle Contraction; Rumen; Substance P | 1982 |
Further evidence for multiple tachykinin receptors.
Topics: Alkylation; Animals; Animals, Newborn; Eledoisin; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Phenoxybenzamine; Physalaemin; Rats; Receptors, Bradykinin; Receptors, Cell Surface; Spinal Cord; Substance P; Urinary Bladder | 1982 |
Two novel related peptides, neuropeptide Y (NPY) and peptide YY (PYY) inhibit the contraction of the electrically stimulated mouse vas deferens.
Topics: Animals; Electric Stimulation; Male; Mice; Muscle Contraction; Nerve Tissue Proteins; Neurons; Neuropeptide Y; Neurotensin; Norepinephrine; Peptide YY; Peptides; Substance P; Sympathetic Nervous System; Vas Deferens | 1982 |
Actions of neurotransmitters and peptides on longitudinal and circular muscle of the rat portal vein.
Topics: Acetylcholine; Angiotensin II; Animals; Female; Male; Muscle Contraction; Muscle, Smooth, Vascular; Neurotransmitter Agents; Norepinephrine; Peptides; Portal Vein; Rats; Rats, Inbred Strains; Serotonin; Substance P | 1983 |
Pharmacological characterization of four related substance P antagonists.
Topics: Acetylcholine; Animals; Blood Pressure; Eledoisin; Guinea Pigs; Histamine; Muscle Contraction; Muscle, Smooth; Physalaemin; Saliva; Substance P | 1982 |
The effects of putative non-adrenergic, non-cholinergic autonomic transmitters on isolated strips from the stomach of the rainbow trout. Salmo gairdneri.
Topics: Adenosine; Adenosine Triphosphate; Animals; Bombesin; Enkephalins; Muscle Contraction; Muscle, Smooth; Neurotensin; Neurotransmitter Agents; Serotonin; Somatostatin; Stomach; Structure-Activity Relationship; Substance P; Trout; Vasoactive Intestinal Peptide | 1983 |
Neurally mediated contraction of ileal longitudinal muscle by substance P.
Topics: Animals; Cholinergic Fibers; Drug Interactions; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Substance P | 1980 |
Bronchial smooth muscle contraction induced by stimulation of capsaicin-sensitive sensory neurons.
Topics: Acetylcholine; Animals; Atropine; Blood Pressure; Bronchi; Capsaicin; Electric Stimulation; Fatty Acids, Unsaturated; Guinea Pigs; Heart Rate; Muscle Contraction; Muscle, Smooth; Neurons, Afferent; Substance P; Trachea; Vagus Nerve | 1982 |
Synthesis and biological activity of glycosylated analogs of the C-terminal hexapeptide and heptapeptide of substance P.
Topics: Animals; Biological Assay; Glycopeptides; Guinea Pigs; Hypothalamus; Ileum; In Vitro Techniques; Indicators and Reagents; Muscle Contraction; Rats; Substance P | 1983 |
Non-cholinergic, non-adrenergic inhibitory neurons in human internal anal sphincter muscle.
Topics: Anal Canal; Bradykinin; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Morphine; Muscle Contraction; Neural Inhibition; Substance P; Vasoactive Intestinal Peptide | 1983 |
Colonic motor and vascular responses to pelvic nerve stimulation and their relation to local peptide release in the cat.
Topics: Animals; Cats; Colon; Gastrointestinal Motility; Muscle Contraction; Parasympathetic Nervous System; Pelvis; Regional Blood Flow; Somatostatin; Substance P; Vascular Resistance; Vasoactive Intestinal Peptide; Vasodilation | 1983 |
The determination of dissociation constants for substance P and substance P analogues in the guinea pig ileum by pharmacological procedures.
Topics: Animals; Binding, Competitive; Guinea Pigs; Ileum; Kassinin; Kinetics; Kinins; Muscle Contraction; Muscle, Smooth; Oligopeptides; Phenoxybenzamine; Physalaemin; Receptors, Cell Surface; Receptors, Neurokinin-1; Substance P | 1983 |
Differentiated contractile responses of gastric smooth muscle to substance P.
Topics: Acetylcholine; Animals; Dogs; Female; Gastric Fundus; Guinea Pigs; Histamine; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Pyloric Antrum; Pylorus; Stomach; Substance P; Tetrodotoxin | 1983 |
Peptides from human placenta: methionine enkephalin and substance P.
Topics: Animals; beta-Endorphin; Biological Assay; Endorphins; Enkephalin, Methionine; Female; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Placenta; Pregnancy; Radioimmunoassay; Rats; Substance P; Tissue Extracts; Vas Deferens | 1981 |
Substance P antagonists release histamine from peritoneal mast cells.
Topics: Animals; Histamine Release; Male; Mast Cells; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Substance P | 1983 |
The role of the N-terminus in the active conformation of the substance P analogues.
Topics: Amino Acids; Animals; Animals, Newborn; Chemical Phenomena; Chemistry; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Protein Conformation; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Neurokinin-1; Spinal Cord; Structure-Activity Relationship; Substance P | 1983 |
Gastrins and cholecystokinins release acetylcholine but not substance P from neurons in the guinea-pig taenia coli.
Topics: Acetylcholine; Animals; Atropine; Cholecystokinin; Colon; Gastrins; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurons; Substance P; Swine | 1983 |
Effects of Met-enkephalin on the substance P-ergic and cholinergic responses in the rabbit iris sphincter muscle.
Topics: Animals; Carbachol; Choline; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Methionine; Female; Iris; Male; Muscle Contraction; Rabbits; Substance P | 1983 |
The pharmacological profile of a substance P (SP) antagonist. Evidence for the existence of subpopulations of SP receptors.
Topics: Animals; Cricetinae; Eledoisin; Guinea Pigs; Ileum; Muscle Contraction; Physalaemin; Rats; Receptors, Cell Surface; Receptors, Neurokinin-1; Substance P; Urinary Bladder | 1983 |
Avidin binding of biotinylated analogues of substance P.
Topics: Animals; Avidin; Biological Assay; Biotin; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; Kinetics; Magnetic Resonance Spectroscopy; Muscle Contraction; Ovalbumin; Peptide Fragments; Protein Binding; Structure-Activity Relationship; Substance P | 1983 |
Sites and mechanisms of action of neuropeptides on canine gastric motility differ in vivo and in vitro.
Topics: Animals; Atropine; Dogs; Dose-Response Relationship, Drug; Gastrointestinal Hormones; Gastrointestinal Motility; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Motilin; Muscle Contraction; Pentagastrin; Stomach; Substance P; Tetrodotoxin | 1983 |
Partial agonists and antagonists for substance P.
Topics: Animals; Atropine; Diphenhydramine; Dogs; Guinea Pigs; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle, Smooth; Substance P | 1983 |
[D-Met2, Pro5]enkephalinamide and dynorphin-(1-13) inhibit the cholinergic contraction induced in the guinea-pig ileum by substance P.
Topics: Animals; Atropine; Dynorphins; Endorphins; Enkephalin, Methionine; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Parasympathetic Nervous System; Peptide Fragments; Substance P | 1983 |
Vasoactive intestinal polypeptide: a putative transmitter in the canine gastric muscularis mucosa.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Epinephrine; Female; Gastric Mucosa; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurons; Neurotransmitter Agents; Norepinephrine; Pentagastrin; Serotonin Antagonists; Substance P; Tetrodotoxin; Vasoactive Intestinal Peptide | 1983 |
Inhibition of smooth muscle contractions induced by capsaicin and electrical transmural stimulation by a substance P antagonist.
Topics: Animals; Capsaicin; Electric Stimulation; Guinea Pigs; Ileum; Iris; Male; Muscle Contraction; Muscle, Smooth; Rabbits; Receptors, Cell Surface; Receptors, Neurokinin-1; Substance P | 1983 |
On the mechanism of contraction and desensitization induced by substance P in the intestinal muscle of the guinea-pig.
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Female; Guinea Pigs; In Vitro Techniques; Intestine, Small; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Rubidium; Substance P; Tetraethylammonium; Tetraethylammonium Compounds; Time Factors | 1983 |
Response of urethral smooth muscles to pharmacological agents. II. Noncholinergic, nonadrenergic agonists and antagonists.
Topics: Animals; Autonomic Agents; Bradykinin; Cats; Dinoprost; Dinoprostone; Female; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Prostaglandins E; Prostaglandins F; Substance P; Urethra | 1983 |
Substance P induced hydrolysis of inositol phospholipids in guinea-pig ileum and rat hypothalamus.
Topics: Animals; Calcium; Female; Guinea Pigs; Hydrolysis; Hypothalamus; Ileum; In Vitro Techniques; Inositol; Male; Muscle Contraction; Muscle, Smooth; Phosphatidylinositols; Rats; Substance P | 1983 |
Immunohistochemical localization of substance P, vasoactive intestinal polypeptide and gastrin-releasing peptide in vas deferens and seminal vesicle, and the effect of these and eight other neuropeptides on resting tension and neurally evoked contractile
Topics: Animals; Carbachol; Dopamine; Gastrin-Releasing Peptide; Gastrointestinal Hormones; Male; Mice; Motor Activity; Muscle Contraction; Nerve Tissue Proteins; Peptides; Seminal Vesicles; Substance P; Vas Deferens; Vasoactive Intestinal Peptide | 1983 |
Substance P and capsaicin-induced contraction of human bronchi.
Topics: Acetylcholine; Aged; Animals; Atropine; Bronchi; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Humans; Middle Aged; Muscle Contraction; Muscle, Smooth; Substance P; Tetrodotoxin | 1983 |
[Synergistic receptor subtypes: an explanation for reserve receptors and for different intrinsic activities of full and partial agonists. Studies on the effect of substance P and its analogs on guinea pig ileum].
Topics: Acetylcholine; Animals; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Receptors, Cell Surface; Receptors, Neurokinin-1; Substance P | 1983 |
Evidence against vasoactive intestinal polypeptide (VIP) as a dilator and in favour of substance P as a constrictor in airway neurogenic responses.
Topics: Animals; Bronchi; Electric Stimulation; Guinea Pigs; Muscle Contraction; Muscle Relaxation; Neuromuscular Junction; Substance P; Trachea; Vasoactive Intestinal Peptide | 1983 |
Pharmacological characterization of a substance P antagonist, [D-Arg1,D-Pro2,D-Trp7,9,Leu11]-substance P.
Topics: Animals; Cricetinae; Dose-Response Relationship, Drug; Drug Interactions; Eledoisin; Guinea Pigs; In Vitro Techniques; Male; Mesocricetus; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Species Specificity; Substance P | 1983 |
Different effects of substance P and vasoactive intestinal peptide on the motor function of bovine intraocular muscles.
Topics: Animals; Cattle; Ciliary Body; In Vitro Techniques; Iris; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neuromuscular Junction; Oculomotor Muscles; Substance P; Synaptic Transmission; Vasoactive Intestinal Peptide | 1983 |
Neural vasodilator control in the rectum of the cat and its possible mediation by vasoactive intestinal polypeptide.
Topics: Animals; Atropine; Cats; Colon; Electric Stimulation; Hemodynamics; Muscle Contraction; Rectum; Regional Blood Flow; Substance P; Time Factors; Vasoactive Intestinal Peptide; Vasodilation | 1983 |
Antagonists of substance P from emphasis on position 11.
Topics: Amino Acid Sequence; Animals; Biological Assay; Guinea Pigs; Ileum; Muscle Contraction; Structure-Activity Relationship; Substance P | 1983 |
Development of a new tachykinin antagonist.
Topics: Animals; Dose-Response Relationship, Drug; Eledoisin; In Vitro Techniques; Kassinin; Mice; Muscle Contraction; Oligopeptides; Peptides; Substance P; Tachykinins; Urinary Bladder | 1984 |
An approach to the self regulatory mechanism of substance P actions: II. Biological activity of new synthetic peptide analogs related both to enkephalin and substance P.
Topics: Animals; Biological Assay; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Muscle Contraction; Rats; Structure-Activity Relationship; Substance P; Vas Deferens | 1983 |
Neuropeptides in the regulation of female genital smooth muscle contractility.
Topics: Adult; Aged; Enkephalins; Female; Genitalia, Female; Humans; Middle Aged; Muscle Contraction; Muscle, Smooth; Nerve Tissue Proteins; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 1983 |
[Effects of bradykinin and capsaicin on substance P-induced reactions in the iris sphincter muscle].
Topics: Animals; Bradykinin; Capsaicin; Electric Stimulation; In Vitro Techniques; Iris; Muscle Contraction; Rabbits; Substance P | 1983 |
Substance P degrading systems of rat parotid and hypothalamus.
Topics: Amino Acid Sequence; Animals; Guinea Pigs; Hypothalamus; Ileum; In Vitro Techniques; Kinetics; Muscle Contraction; Oligopeptides; Parotid Gland; Peptide Fragments; Protease Inhibitors; Pyrrolidonecarboxylic Acid; Rats; Substance P | 1984 |
Contractile responses to substance P and related peptides of the isolated muscularis mucosae of the guinea-pig oesophagus.
Topics: Animals; Electric Stimulation; Eledoisin; Esophagus; Guinea Pigs; In Vitro Techniques; Kinins; Male; Muscle Contraction; Muscle, Smooth; Physalaemin; Substance P | 1984 |
Receptors for substance P. I. The pharmacological preparations.
Topics: Animals; Atropine; Diphenhydramine; Dogs; Female; Guinea Pigs; Heart; Ileum; In Vitro Techniques; Indomethacin; Male; Mesenteric Veins; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Rabbits; Receptors, Neurotransmitter; Substance P; Trachea | 1984 |
Receptors for substance P. III. Classification by competitive antagonists.
Topics: Animals; Dogs; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Weight; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Rabbits; Receptors, Neurotransmitter; Substance P; Trachea | 1984 |
Vasoactive intestinal polypeptide influence on lower urinary tract smooth muscle from human and pig.
Topics: Animals; Carbachol; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Ketoprofen; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Propranolol; Prostaglandins E; Prostaglandins F; Substance P; Swine; Tetrodotoxin; Urethra; Urinary Bladder; Vasoactive Intestinal Peptide | 1984 |
Substance K: a novel mammalian tachykinin that differs from substance P in its pharmacological profile.
Topics: Animals; Blood Pressure; Cricetinae; Dose-Response Relationship, Drug; Duodenum; Guinea Pigs; Ileum; Kassinin; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Oligopeptides; Physalaemin; Rats; Rats, Inbred Strains; Substance P; Urinary Bladder; Vas Deferens | 1984 |
Vascular permeability changes and smooth muscle contraction in relation to capsaicin-sensitive substance P afferents in the guinea-pig.
Topics: Animals; Autonomic Nervous System; Capillary Permeability; Capsaicin; Electric Stimulation; Evans Blue; Female; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth, Vascular; Sensory Receptor Cells; Substance P | 1984 |
Synthesis of substance P antagonists: [D-Pro4, D-Trp7,9,Nle11]-substance P(4-11).
Topics: Amino Acid Sequence; Animals; Chemical Phenomena; Chemistry; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Substance P | 1984 |
Tripeptides acting on opioid receptors in rat colon.
Topics: Animals; Benzomorphans; Colon; Drug Tolerance; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naloxone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Serotonin Antagonists; Substance P | 1984 |
Partial agonists and antagonists for substance P.
Topics: Animals; Dogs; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Peptides; Structure-Activity Relationship; Substance P | 1984 |
Further evidence that substance P partly mediates the action of cholecystokinin octapeptide (CCK-8) on the guinea pig ileum but not gall bladder: studies with a substance P antagonist.
Topics: Animals; Dose-Response Relationship, Drug; Gallbladder; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Organ Specificity; Sincalide; Substance P | 1984 |
Neuronally mediated non-cholinergic contraction of guinea-pig bronchial smooth muscle is inhibited by a substance P antagonist.
Topics: Animals; Atropine; Bronchi; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Substance P | 1984 |
The effect of substance P and related peptides on the guinea-pig lung strip.
Topics: Animals; Chlorpheniramine; Dose-Response Relationship, Drug; Eledoisin; Female; Guinea Pigs; Histamine; In Vitro Techniques; Kinins; Lung; Male; Muscle Contraction; Physalaemin; Substance P | 1984 |
Desensitization of the guinea-pig urinary bladder by the enantiomers of adenylyl 5'-(beta, gamma-methylene)-diphosphonate and by substance P.
Topics: Adenosine Triphosphate; Animals; Atropine; Drug Interactions; Electric Stimulation; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurotransmitter Agents; Stereoisomerism; Substance P; Urinary Bladder | 1984 |
Pardaxin produces postjunctional muscle contraction in guinea-pig intestinal smooth muscle.
Topics: Acetylcholine; Animals; Diphenhydramine; Drug Interactions; Electric Stimulation; Fish Venoms; Guinea Pigs; In Vitro Techniques; Isometric Contraction; Morphine; Muscle Contraction; Muscle, Smooth; Nicotine; Physostigmine; Serotonin; Spider Venoms; Substance P | 1984 |
Substance P can contract the longitudinal muscle of the guinea-pig small intestine by releasing intracellular calcium.
Topics: Acetylcholine; Animals; Calcium; Calcium Radioisotopes; Female; Guinea Pigs; Histamine; In Vitro Techniques; Intestine, Small; Male; Muscle Contraction; Muscle, Smooth; Substance P | 1984 |
A study of [D-Pro2, D-Phe7, D-Trp9]-substance P and [D-Trp7,9]-substance P as tachykinin partial agonists in the rat colon.
Topics: Adsorption; Animals; Carbachol; Colon; Drug Interactions; In Vitro Techniques; Kassinin; Male; Muscle Contraction; Muscle, Smooth; Oligopeptides; Phenoxybenzamine; Rats; Rats, Inbred Strains; Substance P | 1984 |
Undeca- and octa-peptide antagonists for substance P, a study on the guinea pig trachea.
Topics: Animals; Diphenhydramine; Eledoisin; Female; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Peptides; Physalaemin; Substance P; Trachea | 1984 |
Specific and non-specific desensitization of guinea-pig ileal smooth muscle.
Topics: Animals; Calcium; Calcium Channel Blockers; Dioxolanes; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nicardipine; Nifedipine; Parasympatholytics; Potassium; Receptors, Muscarinic; Substance P | 1984 |
Capsaicin and bradykinin-induced substance P-ergic responses in the iris sphincter muscle of the rabbit.
Topics: Animals; Atropine; Bradykinin; Capsaicin; Carbachol; Electric Stimulation; Female; Guanethidine; Iris; Male; Muscle Contraction; Rabbits; Substance P; Tachyphylaxis | 1984 |
Supersensitivity of the rabbit iris sphincter muscle induced by trigeminal denervation: the role of substance P.
Topics: Action Potentials; Animals; Carbachol; Electric Stimulation; Female; Iris; Male; Muscle Contraction; Muscle Denervation; Muscles; Ophthalmic Nerve; Potassium Chloride; Rabbits; Substance P; Time Factors | 1984 |
Comparison of potency of substance P and related peptides on [3H]-acetylcholine release, and contractile actions, in the guinea-pig ileum.
Topics: Acetylcholine; Animals; Calcium; Eledoisin; Guinea Pigs; Ileum; In Vitro Techniques; Kassinin; Male; Muscle Contraction; Muscle, Smooth; Oligopeptides; Peptides; Physalaemin; Substance P; Tachykinins | 1984 |
Inhibitory effects of procaine on the contractile responses of the guinea-pig taenia caecum to acetylcholine, substance P and potassium chloride.
Topics: Acetylcholine; Animals; Calcium; Calcium Chloride; Cecum; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Potassium Chloride; Procaine; Substance P; Verapamil | 1984 |
Post-tetanic potentiation at the nerve-muscle junction in the longitudinal muscle of the guinea-pig ileum. Possible role of substance P.
Topics: Animals; Electromyography; Guinea Pigs; Ileum; In Vitro Techniques; Male; Methysergide; Muscle Contraction; Neuromuscular Junction; Serotonin; Substance P | 1984 |
The effects of topical capsaicin on rat urinary bladder motility in vivo.
Topics: Acetylcholine; Administration, Topical; Animals; Atropine; Capsaicin; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Substance P; Tetrodotoxin; Urinary Bladder | 1984 |
A pharmacological study of oesophageal muscularis mucosae from the cat, dog and American opossum (Didelphis virginiana).
Topics: Acetylcholine; Animals; Cats; Dogs; Electric Stimulation; Esophagus; Histamine; In Vitro Techniques; Mucous Membrane; Muscle Contraction; Muscle, Smooth; Norepinephrine; Opossums; Substance P | 1984 |
Biological evaluation of substance P antagonists.
Topics: Animals; Bombesin; Carbachol; Colon; Electric Stimulation; Guinea Pigs; Histamine Release; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Substance P | 1984 |
Structure-activity relationship of C-terminal hexa- and heptapeptide substance P antagonists as studied in the guinea-pig ileum.
Topics: Amino Acid Sequence; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Structure-Activity Relationship; Substance P | 1984 |
3H-substance P binding to guinea-pig ileum longitudinal smooth muscle membranes.
Topics: Animals; Binding, Competitive; Cell Membrane; Eledoisin; Guinea Pigs; Ileum; Male; Muscle Contraction; Peptide Fragments; Phosphatidylinositols; Pyrrolidonecarboxylic Acid; Substance P; Tritium | 1984 |
Electrophysiological basis of excitation of canine colonic circular muscle by cholinergic agents and substance P.
Topics: Acetylcholine; Action Potentials; Animals; Atropine; Carbachol; Colon; Dogs; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Parasympathomimetics; Substance P; Tachyphylaxis; Tetrodotoxin | 1984 |
The action of substance P on contraction, inositol phospholipids and adenylate cyclase in rat small intestine.
Topics: Adenylyl Cyclases; Animals; Eledoisin; Ileum; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Phosphatidylinositols; Rats; Rats, Inbred Strains; Substance P | 1984 |
Innervation of the muscularis mucosae of canine proximal colon.
Topics: Animals; Bombesin; Colon; Dogs; Electric Stimulation; Female; Hormones; In Vitro Techniques; Intestinal Mucosa; Male; Muscle Contraction; Muscle, Smooth; Peptides; Substance P; Vasoactive Intestinal Peptide | 1984 |
Involvement of neurokinin receptors in the induction but not the maintenance of mechanical allodynia in rat flexor motoneurones.
Topics: Animals; Decerebrate State; Electrophysiology; Injections, Spinal; Male; Motor Neurons; Muscle Contraction; Muscle, Skeletal; Neurokinin A; Neurokinin-1 Receptor Antagonists; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Reflex; Sensory Thresholds; Stimulation, Chemical; Substance P | 1995 |
Involvement of septide-sensitive tachykinin receptors in inositol phospholipid hydrolysis in the rat urinary bladder.
Topics: Amino Acid Sequence; Animals; Benzamides; Hydrolysis; Indoles; Isoindoles; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Phosphatidylinositols; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Urinary Bladder | 1995 |
Long-term effects of small bowel transplantation on intestinal motility.
Topics: Analgesics; Animals; Atropine; Gastrointestinal Motility; Guanethidine; In Vitro Techniques; Jejunum; Male; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Lew; Reference Values; Substance P; Surgical Flaps; Tetrodotoxin; Time Factors; Transplantation, Isogeneic | 1995 |
Comparison of the effects of (+/-) CP 96,345 and L-668,169 on neurokinin receptor mediated responses in rat and guinea-pig isolated tissues.
Topics: Animals; Biphenyl Compounds; Eledoisin; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Neurokinin-1 Receptor Antagonists; Organ Specificity; Peptide Fragments; Peptides, Cyclic; Portal Vein; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Species Specificity; Substance P; Urinary Bladder | 1993 |
Levodropropizine reduces capsaicin- and substance P-induced plasma extravasation in the rat trachea.
Topics: Animals; Antitussive Agents; Blood Pressure; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Heart Rate; In Vitro Techniques; Muscle Contraction; Peripheral Nervous System; Platelet Activating Factor; Propylene Glycols; Rats; Rats, Inbred F344; Substance P; Trachea; Urinary Bladder | 1993 |
Substance P inactivation by aqueous humor.
Topics: 4-Chloromercuribenzenesulfonate; Animals; Aqueous Humor; Biological Assay; Dogs; Ileum; In Vitro Techniques; Isoflurophate; Muscle Contraction; Rabbits; Substance P | 1993 |
Synthesis of a potent antagonist of substance P by replacing the CH2SCH3 and the alpha-carboxamide groups of the methionine at [Orn6]-SP6-11 by benzyl ester groups.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Guinea Pigs; Ileum; Methionine; Molecular Sequence Data; Muscle Contraction; Peptide Fragments; Portal Vein; Rats; Receptors, Tachykinin; Substance P | 1993 |
Structure determination, pharmacological evaluation, and structure-activity studies of a new cyclic peptide substance P antagonist containing the new amino acid 3-prenyl-beta-hydroxytyrosine, isolated from Aspergillus flavipes.
Topics: Amino Acid Sequence; Animals; Aspergillus; Binding, Competitive; Dihydroxyphenylalanine; Guinea Pigs; Humans; Ileum; Molecular Sequence Data; Molecular Structure; Muscle Contraction; Peptides, Cyclic; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P | 1994 |
Substance P-induced contractions of the guinea-pig proximal colon through stimulation of post-junctional tachykinin NK1 receptors.
Topics: Androstanes; Androstenes; Animals; Benzimidazoles; Biphenyl Compounds; Colon; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Neuromuscular Junction; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1993 |
Antagonism of substance P and related peptides by RP 67580 and CP-96,345, at tachykinin NK1 receptor sites, in the rat urinary bladder.
Topics: Animals; Biphenyl Compounds; Blood Proteins; Female; Hypnotics and Sedatives; In Vitro Techniques; Indoles; Isoindoles; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Urinary Bladder | 1994 |
Overnight storage of the porcine isolated splenic artery enhances endothelium-dependent contractions to NG-nitro-L-arginine methyl ester without impairing endothelium-dependent dilator function.
Topics: Animals; Arginine; Endothelium, Vascular; Female; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Serotonin; Splenic Artery; Substance P; Swine; Time Factors; Vasodilation | 1994 |
Tolerance of epicardial coronary endothelium and smooth muscle to hyperkalemia.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Vessels; Endothelium, Vascular; Female; In Vitro Techniques; Isotonic Solutions; Magnesium; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Potassium; Potassium Chloride; Sodium Chloride; Substance P; Swine | 1994 |
Evidence for tachykinin NK-2 receptors in guinea-pig airways from binding and functional studies, using [125I]-[Lys5,Tyr(I2)7,MeLeu9,Nle10]-NKA(4-10).
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Bronchi; Drug Interactions; Female; Guinea Pigs; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neuropeptides; Peptide Fragments; Protease Inhibitors; Protein Binding; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-2; Substance P; Tachykinins | 1994 |
Distinct populations of sensory neurons mediate the peristaltic reflex elicited by muscle stretch and mucosal stimulation.
Topics: Animals; Arginine; Atropine; Capsaicin; Colon; Electric Stimulation; In Vitro Techniques; Intestinal Mucosa; Male; Muscle Contraction; Muscle Denervation; Muscle Relaxation; Muscle, Smooth; Neurons, Afferent; Nitroarginine; Peristalsis; Rats; Rats, Sprague-Dawley; Substance P; Time Factors; Vasoactive Intestinal Peptide | 1994 |
WIN 64821, a novel neurokinin antagonist produced by an Aspergillus sp. II. Biological activity.
Topics: Amino Acid Sequence; Animals; Aspergillus; Astrocytoma; Binding, Competitive; Brain; Calcium; Female; Guinea Pigs; Humans; Ileum; Indoles; Male; Muscle Contraction; Muscle, Smooth; Piperazines; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Submandibular Gland; Substance P; Tumor Cells, Cultured; Urinary Bladder | 1994 |
Involvement of neurokinins in the non-cholinergic response to activation of 5-HT3 and 5-HT4 receptors in guinea-pig ileum.
Topics: 5-Methoxytryptamine; Acetylcholine; Animals; Atropine; Autonomic Nervous System; Choline; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin B; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Substance P | 1994 |
Facilitatory effects of selective agonists for tachykinin receptors on cholinergic neurotransmission: evidence for species differences.
Topics: Adult; Amino Acid Sequence; Animals; Bronchi; Capsaicin; Electric Stimulation; Guinea Pigs; Humans; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Parasympathetic Nervous System; Peptide Fragments; Rabbits; Receptors, Tachykinin; Substance P; Sulfones; Synaptic Transmission; Tachykinins | 1994 |
Tachykinin NK1 receptor subtypes in the rat urinary bladder.
Topics: Animals; Benzamides; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Tachykinin; Substance P; Sulfones; Tachykinins; Urinary Bladder | 1994 |
Capsaicin-sensitive stretch responses in ferret trachealis muscle.
Topics: Animals; Capsaicin; Female; Ferrets; In Vitro Techniques; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Nerve Fibers; Stress, Mechanical; Substance P; Thiorphan; Trachea | 1994 |
Neurogenic "off" contractions are mediated by NK2-receptors in the circular muscle of guinea pig ileum.
Topics: Animals; Atropine; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Peptides, Cyclic; Receptors, Neurokinin-2; Substance P | 1994 |
Different Ca2+ influx pathways mediate tachykinin receptor-induced contraction in circular muscle of guinea-pig colon.
Topics: Action Potentials; Animals; Calcium Channels; Colon; Electrophysiology; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Nifedipine; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P; Sulfones | 1994 |
A regional difference of the effect of tachykinin on cholinergic response evoked by electrical field stimulation in the rabbit airway.
Topics: Acetylcholine; Amino Acid Sequence; Animals; Electric Stimulation; Endopeptidases; Glycopeptides; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Neprilysin; Neurokinin A; Parasympathetic Nervous System; Rabbits; Recombinant Proteins; Respiratory System; Substance P; Tachykinins | 1994 |
Modulation of neurotransmission in guinea-pig airways by galanin and the effect of a new antagonist galantide.
Topics: Animals; Atropine; Bronchi; Electric Stimulation; Galanin; Guinea Pigs; Histamine; Male; Muscle Contraction; Peptides; Propranolol; Receptors, Cholinergic; Substance P; Synaptic Transmission; Trachea | 1994 |
Differences in the effects of NK1-receptor antagonists, (+/-)-CP 96,345 and CP 99,994, on agonist-induced responses in guinea-pig trachea.
Topics: Animals; Biphenyl Compounds; Guinea Pigs; In Vitro Techniques; Indoles; Isoindoles; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Substance P; Trachea | 1994 |
Comparison of tachykinin NK1 and NK2 receptors in the circular muscle of the guinea-pig ileum and proximal colon.
Topics: Animals; Colon; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Nifedipine; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Sulfones | 1994 |
Endothelium-dependent relaxation to substance P in human umbilical artery is mediated via prostanoid synthesis.
Topics: Endothelium, Vascular; Humans; Indomethacin; Muscle Contraction; Potassium; Prostaglandins; Substance P; Umbilical Arteries; Vasodilation | 1994 |
Contractile responses of longitudinal muscle strip to 5-HT and influences of divalent cations in the guinea-pig isolated colon.
Topics: Acetylcholine; Animals; Atropine; Calcium Channels; Cations, Divalent; Colon; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Serotonin; Substance P; Tetrodotoxin | 1994 |
Mechanisms mediating the effects of cholecystokinin on avian small intestine longitudinal smooth muscle.
Topics: Acetylcholine; Amino Acid Sequence; Analysis of Variance; Animals; Chickens; Cholecystokinin; Dose-Response Relationship, Drug; Ileum; In Vitro Techniques; Ketanserin; Male; Mammals; Methiothepin; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurons; Peptide Fragments; Receptors, Cholecystokinin; Receptors, Neurokinin-1; Sincalide; Structure-Activity Relationship; Substance P; Tetragastrin | 1994 |
Effects of clonidine on the reflex cardiovascular responses and release of substance P during muscle contraction.
Topics: Analysis of Variance; Animals; Blood Pressure; Cats; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; Female; Heart Rate; Kidney; Male; Microdialysis; Muscle Contraction; Muscles; Spinal Cord; Substance P; Time Factors | 1994 |
A further analysis of the contraction induced by activation of cholecystokinin A receptors in guinea pig isolated ileum longitudinal muscle-myenteric plexus.
Topics: Animals; Atropine; Biphenyl Compounds; Drug Interactions; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Neuromuscular Junction; Peptide Fragments; Peptides, Cyclic; Physalaemin; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Substance P; Tetragastrin; Tetrodotoxin | 1994 |
Nitrovasodilator-induced relaxation and tolerance development in porcine vena cordis magna: dependence on intact endothelium.
Topics: Animals; Arginine; Cysteine; Dinoprost; Drug Tolerance; Endothelium, Vascular; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitrates; Nitroglycerin; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Substance P; Swine; Vasodilator Agents | 1994 |
[Effect and its mechanism of substance P on contractile activity of isolated antral muscle strips of rat].
Topics: Animals; Cyproheptadine; Diphenhydramine; Dose-Response Relationship, Drug; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Rats; Rats, Sprague-Dawley; Stomach; Substance P | 1994 |
Highly potent substance P antagonists substituted with beta-phenyl- or beta-benzyl-proline at position 10.
Topics: Amino Acid Sequence; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Physalaemin; Pyrrolidonecarboxylic Acid; Rabbits; Rats; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P | 1994 |
Typical and atypical NK1 tachykinin receptor characteristics in the rabbit isolated iris sphincter.
Topics: Animals; In Vitro Techniques; Iris; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Phenoxybenzamine; Pyrrolidonecarboxylic Acid; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P | 1994 |
Epithelium modulates the kinetics of the response to substance P and its intrinsic activity in the guinea-pig trachea.
Topics: Animals; Carbachol; Epithelium; Guinea Pigs; Histamine; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Neprilysin; Neurokinin A; Neurokinin B; Substance P; Thiorphan; Trachea | 1994 |
Use of selective antagonists for further characterization of tachykinin NK-2, NK-1 and possible "septide-selective" receptors in guinea pig bronchus.
Topics: Amino Acid Sequence; Animals; Bronchi; Female; Guinea Pigs; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-2; Substance P; Tachykinins | 1994 |
Endothelium-derived relaxing factor and cyclic GMP-dependent vasorelaxation in human chorionic plate arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Arteries; Bradykinin; Calcimycin; Chorion; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Female; Histamine; Humans; Muscle Contraction; Muscle Relaxation; Nitric Oxide; Pregnancy; Prostaglandin Endoperoxides, Synthetic; Serotonin; Substance P; Thromboxane A2; Vasoconstrictor Agents; Vasodilation | 1994 |
Substance P activates Cl- and K+ conductances in guinea-pig tracheal smooth muscle cells.
Topics: Acetylcholine; Animals; Cell Membrane; Chloride Channels; Guinea Pigs; In Vitro Techniques; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Patch-Clamp Techniques; Potassium Channels; Signal Transduction; Substance P; Trachea | 1994 |
Tachykinin NK1 and NK2 receptors mediate atropine-resistant ileal circular muscle contractions evoked by capsaicin.
Topics: Amino Acid Sequence; Animals; Atropine; Capsaicin; Dipeptides; Drug Resistance; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Oligopeptides; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Ruthenium Red; Substance P; Tetrodotoxin | 1994 |
Pharmacological assessment of spantide II analogues.
Topics: Action Potentials; Amino Acid Sequence; Analgesics; Animals; Female; Guinea Pigs; Histamine Release; Iris; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth, Vascular; Rabbits; Rana catesbeiana; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Structure-Activity Relationship; Substance P; Tachykinins | 1994 |
Tachykinin-induced contractions in the circular muscle of guinea pig ileum.
Topics: Animals; Atropine; Biphenyl Compounds; Dose-Response Relationship, Drug; Electrophysiology; Guinea Pigs; Hypnotics and Sedatives; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Peptides, Cyclic; Rats; Structure-Activity Relationship; Substance P; Tachykinins; Tetrodotoxin | 1994 |
Influence of epithelium removal on allergic contraction of isolated tracheal smooth muscle.
Topics: Acetylcholine; Animals; Antigen-Antibody Reactions; Electric Stimulation; Epithelium; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Substance P; Trachea | 1994 |
Galanin contracts and relaxes guinea pig and canine intestinal smooth muscle cells through distinct receptors.
Topics: Animals; Bradykinin; Dogs; Galanin; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neuropeptides; Osmolar Concentration; Peptide Fragments; Peptides; Potassium Chloride; Receptors, Galanin; Receptors, Gastrointestinal Hormone; Sincalide; Substance P | 1995 |
On the nature of the 5-HT receptor subtype inhibiting acetylcholine release in the guinea-pig ileum.
Topics: Acetylcholine; Animals; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Neurokinin B; Peptide Fragments; Receptors, Neurokinin-3; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Substance P | 1994 |
In vitro characterization of the non-peptide tachykinin NK1 and NK2-receptor antagonists, SR140333 and SR48968 in different rat and guinea-pig intestinal segments.
Topics: Animals; Atropine; Benzamides; Duodenum; Esophagus; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Piperidines; Quinuclidines; Rats; Receptors, Tachykinin; Substance P | 1995 |
5-HT modulates noncholinergic contraction in guinea pig airways in vitro by prejunctional 5-HT1-like receptor.
Topics: Animals; Autonomic Nervous System; Capsaicin; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Norepinephrine; Receptors, Serotonin; Respiratory Physiological Phenomena; Respiratory System; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Substance P | 1994 |
In vitro effects of tachykinins on the smooth musculature of horse gut.
Topics: Analysis of Variance; Animals; Atropine; Colon; Dose-Response Relationship, Drug; Duodenum; Electrophysiology; Eledoisin; Horses; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Regression Analysis; Substance P; Tetrodotoxin | 1994 |
Glucocorticoids inhibit sulfur mustard-induced airway muscle hyperresponsiveness to substance P.
Topics: Administration, Inhalation; Aerosols; Animals; Betamethasone; Epithelial Cells; Epithelium; Ethanol; Glycopeptides; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth; Mustard Gas; Neprilysin; Substance P; Trachea | 1994 |
Nitric oxide induces acetylcholine-mediated contractions in the guinea-pig small intestine.
Topics: Acetylcholine; Animals; Atropine; Biphenyl Compounds; Dose-Response Relationship, Drug; Guinea Pigs; Hexamethonium; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Substance P; Tetrodotoxin | 1994 |
Substance P-induced contraction of airway smooth muscle in young and adult rabbits. Effects of epithelium removal and neutral endopeptidase inhibition.
Topics: Aging; Animals; Bronchi; Epithelium; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neprilysin; Rabbits; Substance P | 1995 |
Tachykinin receptors involved in the contractile effect of the natural tachykinins in the rat gastric fundus.
Topics: Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Female; Gastric Fundus; Indoles; Isoindoles; Male; Methacholine Chloride; Muscle Contraction; Neurokinin A; Neurokinin B; Peptide Fragments; Peptides, Cyclic; Rats; Receptors, Tachykinin; Substance P; Tachykinins | 1994 |
Effects of substance P on gastric motility differ depending on the sites and vagal innervation in conscious dogs.
Topics: Animals; Blood Pressure; Consciousness; Denervation; Dogs; Female; Gastric Fundus; Gastrointestinal Motility; Infusions, Intravenous; Male; Muscle Contraction; Pyloric Antrum; Stomach; Substance P; Vagus Nerve | 1994 |
Tachykinins contract trachea from Fischer 344 rats by interaction with a tachykinin NK1 receptor.
Topics: Animals; Carbachol; In Vitro Techniques; Isometric Contraction; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Rats; Rats, Inbred F344; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Serotonin; Substance P; Tachykinins; Trachea | 1994 |
Specialization of tachykinin NK1 and NK2 receptors in producing fast and slow atropine-resistant neurotransmission to the circular muscle of the guinea-pig colon.
Topics: Action Potentials; Animals; Atropine; Autonomic Nervous System; Colon; Dipeptides; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neuromuscular Junction; Nifedipine; Oligopeptides; Physalaemin; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Synaptic Transmission | 1994 |
Agonist-independent, muscle-type-specific signal transduction pathways in cat esophageal and lower esophageal sphincter circular smooth muscle.
Topics: Animals; Bombesin; Cats; Esophagogastric Junction; Esophagus; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Signal Transduction; Substance P; Type C Phospholipases | 1995 |
Mediator difference in contractions between trachea and bronchus of guinea pig induced by stimulation of C-fibers in vitro.
Topics: Acetylcholine; Animals; Atropine; Bronchi; Chlorpheniramine; Cromolyn Sodium; Electric Stimulation; Female; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nerve Fibers; Substance P; Trachea | 1994 |
Modulation of reflex pressor response to contraction and effect on substance P release by spinal 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Blood Pressure; Cats; Female; Male; Microdialysis; Muscle Contraction; Receptors, Serotonin; Reflex; Spinal Cord; Substance P | 1995 |
Pharmacological analysis of the local and reflex responses to bradykinin on rat urinary bladder motility in vivo.
Topics: Adrenergic beta-Antagonists; Animals; Bradykinin; Capsaicin; Dose-Response Relationship, Drug; Indoles; Indomethacin; Injections, Spinal; Isoindoles; Male; Muscle Contraction; Muscle, Smooth; Piperidines; Quinuclidines; Rats; Rats, Wistar; Reflex; Substance P; Urinary Bladder | 1995 |
SP-induced contraction of airway smooth muscle in normal and allergen-sensitized rabbits: mechanism of action.
Topics: Allergens; Animals; Atropine; Hypersensitivity; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Parasympathetic Nervous System; Rabbits; Respiratory System; Substance P; Synaptic Transmission; Trachea | 1995 |
Tachykinin effects on bladder activity in conscious normal rats.
Topics: Administration, Intravesical; Animals; Benzamides; Female; Indoles; Injections, Intra-Arterial; Isoindoles; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Substance P; Urinary Bladder; Urination | 1995 |
Attenuation of the reflex responses to muscle contraction by the coadministration of antagonists to substance P and somatostatin into the dorsal horn.
Topics: Animals; Blood Pressure; Cats; Electric Stimulation; Heart Rate; Kidney; Lidocaine; Muscle Contraction; Pressoreceptors; Reflex; Somatostatin; Spinal Cord; Substance P; Sympathetic Nervous System; Time Factors | 1995 |
Effect of substance P and capsaicin on stomach fundus and ileum of streptozotocin-diabetic rats.
Topics: Acetylcholine; Age Factors; Animals; Capsaicin; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Gastric Fundus; Ileum; In Vitro Techniques; Male; Muscle Contraction; Rats; Rats, Sprague-Dawley; Streptozocin; Substance P | 1995 |
The peptidergic innervation of the human superficial temporal artery: immunohistochemistry, ultrastructure, and vasomotility.
Topics: Acetylcholinesterase; Animals; Antibodies; Calcitonin Gene-Related Peptide; Fluorescent Antibody Technique; Humans; Microscopy, Electron; Microscopy, Immunoelectron; Muscle Contraction; Muscle, Smooth, Vascular; Nerve Fibers; Neurokinin A; Neuropeptide Y; Neuropeptides; Peptide PHI; Rabbits; Rats; Substance P; Tachykinins; Temporal Arteries; Tyrosine 3-Monooxygenase; Vasoactive Intestinal Peptide | 1995 |
Attenuation of the exercise pressor reflex. Effect of opioid agonist on substance P release in L-7 dorsal horn of cats.
Topics: Analysis of Variance; Animals; Blood Pressure; Cats; Enkephalin, Methionine; Heart Rate; Hemodynamics; In Vitro Techniques; Microdialysis; Muscle Contraction; Physical Exertion; Radioimmunoassay; Receptors, Opioid; Reflex; Spinal Cord; Substance P | 1995 |
Inhibition by cromakalim, pinacidil, terbutaline, theophylline and verapamil of non-cholinergic nerve-mediated contractions of guinea-pig isolated bronchi.
Topics: Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Cromakalim; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Pinacidil; Potassium Channels; Pyrroles; Substance P; Synaptic Transmission; Terbutaline; Theophylline; Verapamil | 1994 |
Antiatherosclerotic effects of oral naftidrofuryl in cholesterol-fed rabbits involve inhibition of neutrophil function.
Topics: Acetylcholine; Administration, Oral; Animals; Aorta, Abdominal; Aorta, Thoracic; Arteriosclerosis; Cholesterol; Cholesterol, Dietary; Disease Models, Animal; Endothelium, Vascular; Fibrinogen; Luminescent Measurements; Luminol; Male; Molsidomine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nafronyl; Neutrophils; Nitric Oxide; Rabbits; Random Allocation; Substance P; Vasodilator Agents; Zymosan | 1995 |
In-vitro exposure of guinea pig main bronchi to 2.5 ppm of nitrogen dioxide does not alter airway smooth muscle response.
Topics: Acetylcholine; Animals; Bronchi; Dose-Response Relationship, Drug; Electric Stimulation; Environmental Exposure; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Nitrogen Dioxide; Substance P | 1995 |
Tachykinin receptors mediating contraction of guinea pig lung strips.
Topics: Acetylcholine; Animals; Benzamides; Biphenyl Compounds; Dipeptides; Guinea Pigs; In Vitro Techniques; Lung; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P; Trachea | 1995 |
Activity of SR 142801 at peripheral tachykinin receptors.
Topics: Analysis of Variance; Animals; Binding, Competitive; Capsaicin; Cricetinae; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mesocricetus; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Portal Vein; Pulmonary Artery; Rabbits; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Trachea | 1995 |
Evidence that tachykinin NK1 and NK2 receptors mediate non-adrenergic non-cholinergic excitation and contraction in the circular muscle of guinea-pig duodenum.
Topics: Action Potentials; Adenosine Diphosphate; Animals; Apamin; Arginine; Atropine; Dose-Response Relationship, Drug; Duodenum; Electric Stimulation; Guanethidine; Guinea Pigs; Indomethacin; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neuromuscular Junction; Nifedipine; Nitroarginine; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Physalaemin; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Suramin; Thionucleotides | 1995 |
In vitro and in vivo evidence for a tachykinin NK1 receptor antagonist effect of vapreotide, an analgesic cyclic analog of somatostatin.
Topics: Acetylcholine; Analgesics; Animals; Binding, Competitive; Brain; Bronchi; Capillary Permeability; Duodenum; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Injections, Spinal; Male; Mice; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Somatostatin; Substance P | 1995 |
Stimulatory mechanism of EM523-induced contractions in postprandial stomach of conscious dogs.
Topics: Animals; Anti-Bacterial Agents; Atropine; Dipeptides; Dogs; Dopamine; Eating; Erythromycin; Hexamethonium; Indoles; Motilin; Muscle Contraction; Naloxone; Ondansetron; Serotonin Antagonists; Stomach; Substance P | 1995 |
Arachidonic acid cascade and stimulation of acetylcholine release by human recombinant interleukin-1 beta in guinea pig ileum.
Topics: Acetylcholine; Animals; Arachidonic Acid; Cholinergic Fibers; Cycloheximide; Electric Stimulation; Female; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Interleukin-1; Intestinal Mucosa; Male; Muscle Contraction; Neuromuscular Junction; Neurons; Nitric Oxide; Parasympathetic Nervous System; Protein Synthesis Inhibitors; Recombinant Proteins; Sensitivity and Specificity; Stimulation, Chemical; Substance P | 1995 |
Effects of sodium metabisulphite on guinea pig contractile airway smooth muscle responses in vitro.
Topics: Acetylcholine; Animals; Bronchi; Bronchoconstriction; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Substance P; Sulfites; Trachea | 1995 |
Endothelium-dependent contraction in intrapulmonary arteries: mediation by endothelial NK1 receptors and TXA2.
Topics: Animals; Cyclooxygenase Inhibitors; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tachykinins; Thromboxane A2; Thromboxane-A Synthase | 1995 |
Calcitonin gene-related peptide (CGRP)-enhanced non-adrenergic non-cholinergic contraction of guinea-pig proximal colon.
Topics: Animals; Atropine; Calcitonin Gene-Related Peptide; Colon; Electric Stimulation; Guanethidine; Guinea Pigs; Hexamethonium; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Receptors, Adrenergic; Receptors, Cholinergic; Serotonin; Substance P | 1995 |
Differential inhibition of cholinergic and noncholinergic neurogenic contractions by mu opioid and alpha-2 adrenergic agonists in guinea pig ileum.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Choline; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Motor Neurons; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Neurotransmitter Uptake Inhibitors; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Opioid, mu; Substance P; Synaptic Transmission | 1993 |
Ascending enteric reflex contraction: roles of acetylcholine and tachykinins in relation to distension and propagation of excitation.
Topics: Acetylcholine; Amino Acid Sequence; Animals; Atropine; Cholinergic Antagonists; Female; Guinea Pigs; Hexamethonium; Hexamethonium Compounds; Ileum; In Vitro Techniques; Isometric Contraction; Isotonic Contraction; Jejunum; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Physalaemin; Receptors, Neurotransmitter; Receptors, Tachykinin; Reflex; Substance P; Synaptic Transmission; Tachykinins | 1993 |
Mechanisms of endothelium-dependent responses to vasoactive agents in isolated porcine coronary arteries.
Topics: Acetylcholine; Animals; Arginine; Calcimycin; Cardiovascular Agents; Coronary Vessels; Endothelium, Vascular; Female; In Vitro Techniques; Isometric Contraction; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; Norepinephrine; Oxyhemoglobins; Serotonin; Substance P; Swine | 1993 |
Characterization of cholecystokinin receptors on the human gallbladder.
Topics: Autoradiography; Benzodiazepinones; Binding Sites; Carbachol; Devazepide; Dose-Response Relationship, Drug; Gallbladder; Gastrins; Hormones; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Iodine Radioisotopes; Muscle Contraction; Muscle, Smooth; Receptors, Cholecystokinin; Reference Values; Secretin; Serotonin; Sincalide; Substance P; Temperature; Vasoactive Intestinal Peptide | 1993 |
Investigation of postmortem functional changes in human cerebral arteries.
Topics: Adult; Aged; Autopsy; Bradykinin; Cerebral Arteries; Epoprostenol; Female; Humans; Male; Middle Aged; Muscle Contraction; Muscle, Smooth, Vascular; Nitroglycerin; Substance P; Time Factors | 1993 |
Inhibition of neutral endopeptidase augments anaphylactic constriction of guinea pig tracheal smooth muscle.
Topics: Anaphylaxis; Animals; Capsaicin; Female; Glycopeptides; Guinea Pigs; Muscle Contraction; Muscle, Smooth; Neprilysin; Substance P; Tachykinins; Trachea | 1993 |
Thyrotropin-releasing hormone: an inhibitory regulatory peptide of feline lower esophageal sphincter.
Topics: Animals; Bethanechol; Bethanechol Compounds; Bombesin; Cats; Dose-Response Relationship, Drug; Esophagogastric Junction; Male; Muscle Contraction; Radioimmunoassay; Substance P; Thyrotropin-Releasing Hormone | 1993 |
Effect of frusemide on bradykinin- and capsaicin-induced contraction of the guinea-pig trachea.
Topics: Animals; Bradykinin; Bronchoconstriction; Capsaicin; Furosemide; Guinea Pigs; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Substance P; Trachea | 1993 |
Functional difference between SP and NKA: relaxation of gastric muscle by SP is mediated by VIP and NO.
Topics: Animals; Arginine; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurokinin A; Nitric Oxide; Nitroarginine; Peptide Fragments; Stomach; Substance P; Tachykinins; Tetrodotoxin; Vasoactive Intestinal Peptide | 1993 |
Gastric vasodilator and motor responses to splanchnic stimulation and tachykinins in the dog.
Topics: Animals; Calcitonin Gene-Related Peptide; Dogs; Electric Stimulation; Female; Hexamethonium; Hexamethonium Compounds; Male; Muscle Contraction; Regional Blood Flow; Splanchnic Nerves; Stomach; Substance P; Tachykinins; Vascular Resistance; Vasodilation | 1993 |
Beta 2-adrenoceptor agonists inhibit NANC neural bronchoconstrictor responses in vitro.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Atenolol; Atropine; Autonomic Nervous System; Bronchoconstriction; Electric Stimulation; Ethanolamines; Formoterol Fumarate; Guinea Pigs; In Vitro Techniques; Isometric Contraction; Male; Muscle Contraction; Phentolamine; Propanolamines; Propranolol; Substance P | 1993 |
The rabbit iris sphincter contains NK1 and NK3 but not NK2 receptors: a study with selective agonists and antagonists.
Topics: Animals; Dactinomycin; Female; Iris; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Peptide Fragments; Rabbits; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1993 |
Substance P release in the spinal cord during the exercise pressor reflex in anaesthetized cats.
Topics: Animals; Blood Pressure; Cats; Electric Stimulation; Heart Rate; Muscle Contraction; Muscle Denervation; Spinal Cord; Spinal Nerve Roots; Substance P | 1993 |
Sensory nerve-mediated relaxation of guinea-pig isolated pulmonary artery: prejunctional modulation by alpha 2-adrenoceptor agonists but not sumatriptan.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcitonin Gene-Related Peptide; Electric Stimulation; Guinea Pigs; Histamine; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Neuromuscular Junction; Neurons, Afferent; Piperazines; Pulmonary Artery; Pyrrolidines; Quinoxalines; Substance P; Sulfonamides; Sumatriptan; Vasoconstrictor Agents; Yohimbine | 1993 |
Effect of passive sensitization on the mechanical activity of human isolated bronchial smooth muscle induced by substance P, neurokinin A and VIP.
Topics: Acetylcholine; Adult; Aged; Female; Glycopeptides; Histamine; Humans; Hypersensitivity; Immunization, Passive; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Neurokinin A; Phosphorylation; Substance P; Thermolysin; Vasoactive Intestinal Peptide | 1993 |
Evidence for the presence of a septide-sensitive tachykinin receptor in the circular muscle of the guinea-pig ileum.
Topics: Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscles; Neurokinin A; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins | 1993 |
Characterization of sensory neurotransmission and its inhibition via alpha 2B-adrenoceptors and via non-alpha 2-receptors in rabbit iris.
Topics: Animals; Cholinergic Fibers; Electric Stimulation; In Vitro Techniques; Iris; Kinins; Muscle Contraction; Neurons, Afferent; Neurotransmitter Agents; Oxymetazoline; Rabbits; Receptors, Adrenergic, alpha; Signal Transduction; Substance P; Sympathomimetics | 1993 |
Receptor-mediated specific biological activity of a beta-amyloid protein fragment for NK-1 substance P receptors.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1993 |
Effects of an NK1 receptor antagonist, FK888, on constriction and plasma extravasation induced in guinea pig airway by neurokinins and capsaicin.
Topics: Animals; Capillary Permeability; Capsaicin; Dipeptides; Guinea Pigs; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Trachea | 1993 |
Chimeric galanin analogs that function as antagonists in the CNS are full agonists in gastrointestinal smooth muscle.
Topics: Animals; Bradykinin; Cyclic AMP; Digestive System; Digestive System Physiological Phenomena; Galanin; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Peptides; Rats; Substance P | 1993 |
Endogenous tachykinins facilitate transmission through parasympathetic ganglia in guinea-pig trachea.
Topics: Acetylcholine; Animals; Capsaicin; Electric Stimulation; Ganglia, Parasympathetic; Glycopeptides; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Neuropeptides; Peptide Fragments; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Synaptic Transmission; Tachykinins; Trachea; Vagus Nerve | 1993 |
Adenosine inhibits efferent function of extrinsic capsaicin-sensitive sensory nerves in the enteric nervous system.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Adenosine; Animals; Capsaicin; Electric Stimulation; Electrophysiology; Female; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mesentery; Muscle Contraction; Myenteric Plexus; Nerve Fibers; Neurons, Afferent; Neurons, Efferent; Substance P; Theophylline | 1993 |
SR 57227A: a potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo.
Topics: Animals; Blood-Brain Barrier; Brain; Cells, Cultured; Cerebral Cortex; Corpus Striatum; Guinea Pigs; Ileum; Indoles; Male; Mice; Muscle Contraction; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Substance P; Tropisetron | 1993 |
Changes in contractile responses of the urinary bladder to substance P in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Capsaicin; Diabetes Mellitus, Experimental; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Organ Size; Prostaglandins; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Urinary Bladder | 1993 |
Characterization of tachykinin receptors in ferret trachea by peptide agonists and nonpeptide antagonists.
Topics: Animals; Ferrets; Macromolecular Substances; Male; Muscle Contraction; Neurokinin A; Peptides; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins; Trachea | 1993 |
Tachykinins contract the circular muscle of the human esophageal body in vitro via NK2 receptors.
Topics: Adolescent; Adult; Aged; Atropine; Benzamides; Biphenyl Compounds; Carbachol; Dose-Response Relationship, Drug; Esophagus; Glycopeptides; Humans; Isometric Contraction; Middle Aged; Muscle Contraction; Muscle, Smooth; Neprilysin; Neurokinin A; Neurokinin B; Piperidines; Receptors, Tachykinin; Substance P; Tachykinins; Tetrodotoxin | 1993 |
Pharmacological analysis of receptors involved in the late, tachykininergic contractile response to electrical transmural stimulation in isolated rabbit iris sphincter muscle.
Topics: Animals; Electric Stimulation; Iris; Male; Muscle Contraction; Peptides, Cyclic; Rabbits; Receptors, Tachykinin; Substance P; Tachykinins | 1993 |
Pharmacological evidence for the release of galanin from rat stomach.
Topics: Animals; Female; Galanin; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Peptides; Rats; Rats, Sprague-Dawley; Stomach; Substance P | 1993 |
Relations of contractile hyperreactivity to tachykinins in rabbit trachea.
Topics: Acetylcholine; Alternaria; Analgesics; Animals; Antigens, Fungal; Atropine; Capsaicin; Dose-Response Relationship, Drug; Electric Stimulation; Hypersensitivity; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Potassium Chloride; Rabbits; Reference Values; Serotonin; Substance P; Tetrodotoxin; Trachea | 1993 |
A study on the peptidergic nerves (VIP, substance P) in the colon of patients with diverticular disease.
Topics: Atropine; Colon; Diverticulitis, Colonic; Electric Stimulation; Humans; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Phenoxybenzamine; Propranolol; Substance P; Tetrodotoxin; Vasoactive Intestinal Peptide | 1993 |
Regional differences in contractile responses to tachykinin agonists and to electrical field stimulation are dependent on distribution of proteinase activity.
Topics: Animals; Bronchi; Electric Stimulation; Endopeptidases; Glycopeptides; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Protease Inhibitors; Rabbits; Substance P; Trachea | 1993 |
Role of NK-1 receptor in central cardiovascular regulation in rats: studies on a novel non-peptide antagonist, CP-96,345, of substance P NK-1 receptor.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Cerebral Ventricles; Heart Rate; Hypnotics and Sedatives; Injections, Intraventricular; Male; Muscle Contraction; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Rats; Receptors, Neurokinin-1; Substance P; Tachykinins; Vas Deferens | 1993 |
In vivo and in vitro activity of SR 48,968, a non-peptide tachykinin NK-2 receptor antagonist.
Topics: Animals; Benzamides; Biphenyl Compounds; Blood Pressure; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Piperidines; Rats; Receptors, Neurokinin-2; Saliva; Substance P; Sulfones; Urinary Bladder | 1993 |
Novel substance P analogues inhibit circular muscle contraction of guinea pig ileum and depolarization of new born rat spinal cord induced by substance P.
Topics: Animals; Animals, Newborn; Guinea Pigs; Ileum; In Vitro Techniques; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Neurokinin A; Rats; Spinal Cord; Structure-Activity Relationship; Substance P | 1993 |
The pharmacological properties of FK888, a novel dipeptide NK1 antagonist.
Topics: Animals; Bronchoconstriction; Capsaicin; Cell Membrane; Dipeptides; Edema; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Indoles; Kinetics; Lung; Muscle Contraction; Muscle, Smooth; Neurokinin A; Receptors, Neurokinin-1; Substance P | 1993 |
Substance P-evoked circular muscle contractions have a close connection with serotonergic neurons in guinea-pig ileum.
Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurons; Serotonin; Substance P; Tropisetron | 1993 |
Spinal effects of selective NK-1 and NK-2 receptor antagonists on bladder motility in anesthetized rats.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Afferent Pathways; Animals; Capsaicin; Indoles; Isoindoles; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Physalaemin; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Reflex; Spinal Cord; Substance P; Urinary Bladder; Urination | 1993 |
Tachykinin NK-1 and NK-2 receptors in the circular muscle of the guinea-pig proximal colon.
Topics: Animals; Benzamides; Biphenyl Compounds; Colon; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Peptides, Cyclic; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Sulfones; Tetrodotoxin | 1993 |
Intrathecal administration of NK1 receptor antagonist, CP96345, inhibits the micturition reflex in the rat.
Topics: Animals; Biphenyl Compounds; Female; Injections, Spinal; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Neurokinin-1; Reflex; Spinal Cord; Substance P; Urinary Bladder; Urination | 1993 |
Effect of tachykinins on the acetylcholine output stimulated by nicotine from guinea-pig bladder.
Topics: Acetylcholine; Animals; Female; Guanethidine; Guinea Pigs; Hexamethonium; Hexamethonium Compounds; Kinetics; Muscle Contraction; Muscle, Smooth; Nicotine; Receptors, Tachykinin; Substance P; Tachykinins; Tetrodotoxin; Urinary Bladder | 1993 |
Neuromodulation mediated by neurokinin-1 subtype receptors in adult rabbit airways.
Topics: Acetylcholine; Animals; Electric Stimulation; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Nervous System Physiological Phenomena; Parasympathetic Nervous System; Peptide Fragments; Physalaemin; Pyrrolidonecarboxylic Acid; Rabbits; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Tetrodotoxin; Trachea | 1993 |
Effect of thiazide diuretics against neurally mediated contraction of guinea pig airways. Contribution of carbonic anhydrase.
Topics: Acetylcholine; Animals; Benzothiadiazines; Bronchi; Carbachol; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Diuretics; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Sodium Chloride Symporter Inhibitors; Substance P; Trachea | 1993 |
The interaction of the NK1 receptor antagonist CP-96,345 with L-type calcium channels and its functional consequences.
Topics: Animals; Biphenyl Compounds; Calcium Channels; Cerebral Cortex; Diltiazem; Guinea Pigs; In Vitro Techniques; Male; Membranes; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Neurokinin-1 Receptor Antagonists; Nimodipine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Stereoisomerism; Substance P; Succinimides; Trachea | 1993 |
Effects of graded muscle contractions on spinal cord substance P release, arterial blood pressure, and heart rate.
Topics: Animals; Arteries; Blood Pressure; Cats; Denervation; Heart Rate; Male; Microdialysis; Muscle Contraction; Radioimmunoassay; Spinal Cord; Spinal Nerve Roots; Substance P | 1993 |
Effects of cromakalim on bradykinin-, histamine- and substance P-induced airway microvascular leakage in the guinea-pig.
Topics: Animals; Benzopyrans; Bradykinin; Bronchi; Capillary Permeability; Cromakalim; Electric Stimulation; Evans Blue; Female; Guinea Pigs; Histamine; In Vitro Techniques; Injections, Intravenous; Lung; Male; Muscle Contraction; Muscle, Smooth; Pyrroles; Respiratory System; Substance P; Trachea | 1993 |
5-HT receptors mediating contractions of the isolated human coronary artery.
Topics: Adolescent; Adult; Arteries; Blood Platelets; Child; Child, Preschool; Coronary Vessels; Dose-Response Relationship, Drug; Ergotamine; Female; Humans; In Vitro Techniques; Infant; Ketanserin; Male; Metergoline; Middle Aged; Muscle Contraction; Muscle, Smooth, Vascular; Pindolol; Potassium; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Substance P; Sumatriptan; Yohimbine | 1993 |
Importance of the leucine side-chain to the spasmogenic activity and binding of substance P analogues.
Topics: Amino Acid Sequence; Animals; Binding Sites; Computer Simulation; Guinea Pigs; Ileum; Leucine; Magnetic Resonance Spectroscopy; Male; Models, Chemical; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Peptides; Protein Conformation; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Stereoisomerism; Structure-Activity Relationship; Substance P | 1993 |
Modulation of neuroeffector transmission by endogenous nitric oxide: a role for acetylcholine receptor-activated nitric oxide formation, as indicated by measurements of nitric oxide/nitrite release.
Topics: Acetylcholine; Amino Acid Oxidoreductases; Animals; Arginine; Atropine; Electric Stimulation; Female; Guinea Pigs; Ileum; Iris; Luminescent Measurements; Male; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Nitrites; omega-N-Methylarginine; Rabbits; Receptors, Cholinergic; Substance P; Synaptic Transmission | 1993 |
Site of action of galanin in the cholinergic transmission of guinea pig small intestine.
Topics: Acetylcholine; Animals; Carbachol; Electric Stimulation; Female; Galanin; gamma-Aminobutyric Acid; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Intestine, Small; Male; Muscle Contraction; Neurons; Norepinephrine; Parasympathetic Nervous System; Parasympathomimetics; Potassium; Substance P; Synaptic Transmission | 1995 |
Regulation by phosphodiesterase isoenzymes of non-adrenergic non-cholinergic contraction in guinea-pig isolated main bronchus.
Topics: Animals; Autonomic Nervous System; Bronchi; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Isoenzymes; Male; Muscle Contraction; Muscle Relaxation; Neurons, Afferent; Neuropeptides; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Substance P | 1995 |
Characterization of a postjunctional 5-HT receptor mediating relaxation of guinea-pig isolated ileum.
Topics: 5-Methoxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cloning, Molecular; Drug Interactions; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; N,N-Dimethyltryptamine; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Substance P; Sumatriptan; Tryptamines | 1995 |
Analysis of the mechanisms underlying the contractile response induced by the hydroalcoholic extract of Phyllanthus urinaria in the guinea-pig urinary bladder in-vitro.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Benzamides; Dipeptides; Ethanol; Female; Guinea Pigs; In Vitro Techniques; Indoles; Ion Channels; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Neurokinin A; Piperidines; Plant Extracts; Plants, Medicinal; Receptors, Tachykinin; Substance P; Urinary Bladder | 1995 |
Further evidence that tachykinin-induced contraction of human isolated bronchus is mediated only by NK2-receptors.
Topics: Aged; Bronchi; Carbachol; Female; Glycopeptides; Humans; Male; Middle Aged; Muscle Contraction; Neurokinin A; Neurokinin B; Peptide Fragments; Protease Inhibitors; Receptors, Neurokinin-2; Substance P; Tachykinins | 1995 |
Pharmacological characterization of tachykinin NK2 receptors on isolated human urinary bladder, prostatic urethra and prostate.
Topics: Humans; In Vitro Techniques; Male; Muscle Contraction; Peptides, Cyclic; Physalaemin; Prostate; Receptors, Neurokinin-2; Substance P; Urethra; Urinary Bladder | 1996 |
Impaired intracellular signal transduction in gastric smooth muscle of diabetic BB/W rats.
Topics: Acetylcholine; Animals; Calcium; Carbachol; Cell Membrane; Cells, Cultured; Cytosol; Diabetes Mellitus, Type 1; Electric Stimulation; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Male; Muscle Contraction; Muscle, Smooth; Potassium Chloride; Protein Kinase C; Rats; Rats, Inbred BB; Reference Values; Signal Transduction; Sodium Fluoride; Stomach; Substance P; Tetradecanoylphorbol Acetate | 1996 |
2-Phenyl-4-quinolinecarboxamides: a novel class of potent and selective non-peptide competitive antagonists for the human neurokinin-3 receptor.
Topics: Animals; Binding, Competitive; CHO Cells; Ciliary Body; Cricetinae; Cricetulus; Drug Design; Guinea Pigs; Humans; Muscle Contraction; Peptide Fragments; Piperidines; Quinolines; Rabbits; Receptors, Neurokinin-3; Recombinant Fusion Proteins; Structure-Activity Relationship; Substance P | 1996 |
In vivo evidence for the involvement of tachykinin NK3 receptors in the hexamethonium-resistant inhibitory transmission in the rat colon.
Topics: Adrenergic Agents; Animals; Colon; Dose-Response Relationship, Drug; Guanethidine; Hexamethonium; Male; Muscle Contraction; Neurokinin A; NG-Nitroarginine Methyl Ester; Nicotinic Antagonists; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P | 1996 |
Sensory nerves play an efferent role in the function of the arterioles, but not the dilator muscle, of the rat iris.
Topics: Adrenergic Fibers; Animals; Arterioles; Autoradiography; Base Sequence; Binding Sites; Calcitonin Gene-Related Peptide; Efferent Pathways; Electrophysiology; Immunohistochemistry; Iris; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth, Vascular; Muscles; Neurons, Afferent; Polymerase Chain Reaction; Rats; Rats, Wistar; Receptors, Tachykinin; RNA, Messenger; Substance P | 1996 |
Effect of SR 142801 on nitric oxide-dependent and independent responses to tachykinin NK3 receptor agonists in isolated guinea-pig colon.
Topics: Animals; Arginine; Colon; Electric Stimulation; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Substance P | 1995 |
Association and cosegregation of stroke with impaired endothelium-dependent vasorelaxation in stroke prone, spontaneously hypertensive rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Basilar Artery; Blood Pressure; Cerebrovascular Disorders; Crosses, Genetic; Disease Susceptibility; Endothelium, Vascular; Female; Heart Rate; Hypertension; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitroglycerin; Nitroprusside; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Serotonin; Substance P; Vasodilation | 1996 |
Analysis of contributions of acetylcholine and tachykinins to neuro-neuronal transmission in motility reflexes in the guinea-pig ileum.
Topics: Acetylcholine; Afferent Pathways; Animals; Efferent Pathways; Female; Gastrointestinal Motility; Guinea Pigs; Hexamethonium; Ileum; Male; Membrane Potentials; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Nicotinic Antagonists; Peptide Fragments; Receptors, Neurokinin-3; Reflex; Scopolamine; Substance P; Synaptic Transmission; Tachykinins | 1996 |
EFFECTS OF HISTAMINE AND RELATED COMPOUNDS ON THE BOVINE IRIS DILATOR.
Topics: Analysis of Variance; Animals; Cattle; Chlorpheniramine; Cimetidine; Diphenhydramine; Dose-Response Relationship, Drug; Female; Guinea Pigs; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Ileum; Iris; Lethal Dose 50; Male; Methylhistamines; Muscle Contraction; Muscle, Smooth; p-Methoxy-N-methylphenethylamine; Piperidines; Potassium; Pyrilamine; Ranitidine; Receptors, Histamine H1; Substance P | 1996 |
Functional evidence for NO-synthase activation by substance P through a mechanism not involving classical tachykinin receptors in guinea-pig ileum in vitro.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; omega-N-Methylarginine; Substance P | 1996 |
Antagonism of cholinergic nerve-mediated contractions by the sensory nerve inhibitory system in rat bronchi.
Topics: Acetylcholine; Analgesics; Animals; Bronchi; Capsaicin; Cyclooxygenase Inhibitors; Electric Stimulation; Epithelium; In Vitro Techniques; Indoles; Isoindoles; Male; Meclofenamic Acid; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Parasympathetic Nervous System; Prostaglandins; Rats; Rats, Sprague-Dawley; Substance P | 1996 |
Effects of omega-conotoxin GVIA on the activation of capsaicin-sensitive afferent sensory nerves in guinea pig airway tissues.
Topics: Animals; Bronchoconstriction; Calcium Channel Blockers; Capsaicin; Guinea Pigs; Lung; Male; Mollusk Venoms; Muscle Contraction; Muscle, Smooth; omega-Conotoxin GVIA; Peptides; Permeability; Substance P | 1996 |
Repeated allergen exposure enhances excitatory nonadrenergic noncholinergic nerve-mediated bronchoconstriction in sensitized guinea-pigs.
Topics: Allergens; Animals; Bronchi; Bronchial Provocation Tests; Bronchoconstriction; Electric Stimulation; Guinea Pigs; Lung; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Ovalbumin; Substance P | 1996 |
Effects of capsaicin on detrusor contractility of rats: an in vivo and isolated whole bladder study.
Topics: Administration, Intravesical; Animals; Capsaicin; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Sprague-Dawley; Substance P; Urinary Bladder; Urinary Retention | 1996 |
Mechanisms involved in the contractile responses induced by the hydroalcoholic extract of Phyllanthus urinaria on the guinea pig isolated trachea: evidence for participation of tachykinins and influx of extracellular Ca2+ sensitive to ruthenium red.
Topics: Animals; Calcium; Calcium Channel Blockers; Extracellular Space; Female; Guinea Pigs; In Vitro Techniques; Leukotriene Antagonists; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Plant Extracts; Plants, Medicinal; Platelet Activating Factor; Prostaglandin Antagonists; Receptors, Neurokinin-2; Ruthenium Red; Substance P; Tachykinins; Trachea | 1996 |
Platelet-activating factor (PAF) stimulates giant migrating contractions during ileal inflammation.
Topics: Animals; Calcium; Dogs; Female; Ileitis; Ileum; Male; Methacholine Chloride; Motilin; Muscle Contraction; Neostigmine; Platelet Activating Factor; Substance P | 1996 |
Effect of parasympathetic and sensory transmitters on human epicardial coronary arteries and veins.
Topics: Acetylcholine; Adult; Aged; Arteries; Atropine; Calcitonin Gene-Related Peptide; Coronary Vessels; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Male; Middle Aged; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Neurons, Afferent; Neurotransmitter Agents; Parasympathetic Nervous System; Substance P; Vasoactive Intestinal Peptide; Veins | 1996 |
Modulation of gut substance P after whole-body irradiation. A new pathological feature.
Topics: Animals; Dose-Response Relationship, Radiation; Gamma Rays; Ileum; Intestinal Mucosa; Male; Muscle Contraction; Muscle, Smooth; Radiation Dosage; Rats; Rats, Wistar; Substance P; Whole-Body Irradiation | 1996 |
Contractile responses of rat duodenum caused by transmural nerve stimulation: interaction between tachykininergic and cholinergic mechanisms.
Topics: Acetylcholine; Animals; Atropine; Duodenum; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Substance P; Tachykinins | 1996 |
Effects of various peptides on isolated rabbit lower esophageal sphincter.
Topics: Animals; Atropine; Bombesin; Calcitonin Gene-Related Peptide; Diphenhydramine; Dose-Response Relationship, Drug; Esophagogastric Junction; Male; Motilin; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neuropeptide Y; Peptides; Phentolamine; Propranolol; Rabbits; Substance P; Vasoactive Intestinal Peptide | 1996 |
Actions of galanin and some of its analogues on rat isolated gastric fundus.
Topics: Analysis of Variance; Animals; Bucladesine; Calcium Channel Blockers; Dibenzylchlorethamine; Diltiazem; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Female; Galanin; Gastric Fundus; Glyburide; Lethal Dose 50; Male; Muscle Contraction; Muscle, Smooth; Papaverine; Parasympatholytics; Rats; Rats, Wistar; Substance P | 1996 |
In vitro pharmacological effects of S 12370 (2-[4-benzhydryloxypiperidinoethyl]isoxindole; an antibronchoconstrictor agent) in normal and sensitized tissue.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Arachidonic Acid; Benzhydryl Compounds; Binding, Competitive; Electric Stimulation; Guinea Pigs; Heart; Histamine; Leukotriene D4; Lung; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Ovalbumin; Oxindoles; Prostaglandin Endoperoxides, Synthetic; Rats; Receptors, Adrenergic, beta; Serotonin; Substance P; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents | 1996 |
Effect of substance P and met-enkephalin on cat colonic smooth muscle activity.
Topics: Animals; Cats; Colon; Enkephalin, Methionine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Naloxone; Substance P | 1996 |
Mediation by prostaglandins of the stimulatory effect of substance P on cyclic AMP production in dog iris sphincter smooth muscle.
Topics: Adenylyl Cyclases; Animals; Cyclic AMP; Cyclooxygenase Inhibitors; Dinoprostone; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Indomethacin; Iris; Kinetics; Muscle Contraction; Muscle, Smooth; Phospholipases A; Phospholipases A2; Prostaglandins; Quinacrine; Receptors, Prostaglandin; Substance P | 1996 |
Pharmacological activation changes stiffness of cultured human airway smooth muscle cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Actins; Bradykinin; Bronchodilator Agents; Bucladesine; Carbachol; Cells, Cultured; Colforsin; Collagen; Cytoskeleton; Dinoprostone; Histamine; Humans; Isoproterenol; Kinetics; Magnetics; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Myosins; Potassium Chloride; Substance P; Time Factors; Trachea | 1996 |
Endogenous NO inhibits NANC but not cholinergic neurotransmission to circular muscle of guinea pig ileum.
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apamin; Bethanechol; Biphenyl Compounds; Electric Stimulation; Guanethidine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Neurokinin-1 Receptor Antagonists; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Scopolamine; Substance P; Synaptic Transmission; Tetrodotoxin; Vasoactive Intestinal Peptide | 1996 |
Contractile action of galanin analogues on rat isolated gastric fundus strips is modified by tachyphylaxis to substance P.
Topics: Amino Acid Sequence; Animals; Galanin; Gastric Fundus; Kinetics; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Rats; Rats, Wistar; Substance P; Swine; Tachyphylaxis | 1996 |
Effect of celiac ganglionectomy on tachykinin innervation, receptor distribution and intestinal responses in the rat.
Topics: Animals; Ganglia, Sympathetic; Ganglionectomy; Immunohistochemistry; In Vitro Techniques; Intestinal Mucosa; Intestines; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Tachykinins | 1996 |
Effect of extrinsic denervation in a canine model of jejunoileal autotransplantation on mechanical and electrical activity of jejunal circular smooth muscle.
Topics: Animals; Bethanechol; Denervation; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Female; Ileum; Jejunum; Membrane Potentials; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Substance P; Transplantation, Autologous | 1997 |
Characterization of NK3 receptors in rabbit isolated iris sphincter muscle.
Topics: Adrenergic alpha-Antagonists; Animals; Autoradiography; Benzamides; Electric Stimulation; In Vitro Techniques; Iris; Male; Muscle Contraction; Muscle, Smooth; Neurokinin B; Peptide Fragments; Phenoxybenzamine; Piperidines; Rabbits; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P | 1997 |
Spontaneously released substance P and bradykinin from isolated guinea-pig bladder.
Topics: Animals; Bradykinin; Captopril; Female; Glycopeptides; Guinea Pigs; Muscle Contraction; Peptidyl-Dipeptidase A; Protease Inhibitors; Substance P; Urinary Bladder | 1997 |
Calcitonin gene-related peptide inhibits nonadrenergic noncholinergic contraction of guinea pig distal colon.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Colon; Dose-Response Relationship, Drug; Electric Stimulation; Gap Junctions; Guinea Pigs; Humans; Male; Miotics; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Substance P; Synaptic Transmission | 1997 |
Post-synaptic 5-HT4 receptor modulation of tachykinergic excitation of rat oesophageal tunica muscularis mucosae.
Topics: 5-Methoxytryptamine; Animals; Carbachol; Esophagus; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Substance P | 1997 |
Localization of leukaemia inhibitory factor to airway epithelium and its amplification of contractile responses to tachykinins.
Topics: Animals; Capsaicin; Carbachol; Epithelium; Female; Growth Inhibitors; Guinea Pigs; Humans; Immunohistochemistry; In Vitro Techniques; Interleukin-6; Isoproterenol; Leukemia Inhibitory Factor; Lymphokines; Muscle Contraction; Neurokinin A; Substance P; Trachea | 1997 |
Galanin, galantide and galanin (1-14)-[alpha-aminobutyric acid8]-scyliorhinin-I: structure dependent effects on the rat isolated gastric fundus.
Topics: Analysis of Variance; Animals; Chromatography; Dose-Response Relationship, Drug; Female; Galanin; Gastric Fundus; In Vitro Techniques; Male; Mass Spectrometry; Muscle Contraction; Muscle, Smooth; Rats; Rats, Wistar; Structure-Activity Relationship; Substance P | 1997 |
Involvement of both L- and N-type voltage-dependent Ca2+ channels in KCl- and veratridine-evoked transmitter release from non-adrenergic, non-cholinergic nerves in the rabbit iris sphincter muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Analgesics; Animals; Atropine; Calcium Channel Blockers; Calcium Channels; Capsaicin; Iris; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Nicardipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Peptides; Potassium Chloride; Rabbits; Receptors, Tachykinin; Sodium Channels; Spider Venoms; Substance P; Synaptic Transmission; Veratridine | 1997 |
Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 1. Identification of the 4-quinolinecarboxamide framework.
Topics: Animals; Binding, Competitive; Chemical Phenomena; Chemistry, Physical; CHO Cells; Cricetinae; Humans; Hydrogen Bonding; Molecular Structure; Muscle Contraction; Peptide Fragments; Quinolines; Rabbits; Receptors, Neurokinin-3; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Substance P | 1997 |
Comparative study of the effects of capsaicin on the contractility of normal and spinal cord injured human bladders.
Topics: Analgesics; Bethanechol; Capsaicin; Electric Stimulation; Humans; In Vitro Techniques; Muscarinic Agonists; Muscle Contraction; Spinal Cord Injuries; Substance P; Urinary Bladder | 1997 |
Synthesis and biological activity of novel backbone-bicyclic substance-P analogs containing lactam and disulfide bridges.
Topics: Animals; Disulfides; Guinea Pigs; Ileum; In Vitro Techniques; Indicators and Reagents; Lactams; Muscle Contraction; Muscle, Smooth; Neurons; Peptide Library; Peptides, Cyclic; Protein Conformation; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P | 1997 |
CGRP potentiates excitatory transmission to the circular muscle of guinea-pig colon.
Topics: Animals; Atropine; Calcitonin Gene-Related Peptide; Colon; Electric Stimulation; Guanethidine; Guinea Pigs; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurotransmitter Agents; Receptors, Cholinergic; Substance P; Synaptic Transmission; Tachykinins | 1997 |
Dual effects of PACAP on guinea pig gallbladder muscle via PACAP-preferring and VIP/PACAP-preferring receptors.
Topics: Animals; Atropine; Cholecystokinin; Gallbladder; Guinea Pigs; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth; Neuropeptides; Neurotransmitter Agents; Nitroprusside; Phentolamine; Pituitary Adenylate Cyclase-Activating Polypeptide; Proglumide; Propranolol; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Pituitary Hormone; Receptors, Vasoactive Intestinal Peptide; Substance P; Tetrodotoxin; Time Factors | 1997 |
A novel motility effect of tachykinins in normal and inflamed colon.
Topics: Animals; Atropine; Colon; Dogs; Female; Hexamethonium; Inflammation; Infusions, Intra-Arterial; Male; Muscle Contraction; Muscle, Smooth; Myoelectric Complex, Migrating; Receptors, Tachykinin; Substance P; Tetrodotoxin | 1997 |
Tachykinin antagonist FK224 inhibits neurokinin A-, substance P- and capsaicin-induced human bronchial contraction.
Topics: Acetylcholine; Adult; Aged; Bronchi; Capsaicin; Glycopeptides; Histamine; Humans; In Vitro Techniques; Leukotriene D4; Middle Aged; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptides, Cyclic; Protease Inhibitors; Receptors, Tachykinin; Substance P; Tachykinins | 1997 |
Tachykinin NK1 and NK2 receptors mediate non-adrenergic non-cholinergic excitatory neuromuscular transmission in the human ileum.
Topics: Aged; Aged, 80 and over; Apamin; Electrophysiology; Enzyme Inhibitors; Humans; Ileum; Middle Aged; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Neuromuscular Junction; Nitroarginine; Peptide Fragments; Peptides, Cyclic; Physalaemin; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Synaptic Transmission | 1997 |
Effect of hyperoxia on substance P expression and airway reactivity in the developing lung.
Topics: Acetylcholine; Animals; Hyperoxia; In Vitro Techniques; Lung; Muscle Contraction; Muscle, Smooth; Protein Biosynthesis; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance P; Tachykinins; Trachea; Transcription, Genetic | 1997 |
Sensory nerve-mediated inhibitory responses in airways of F344 rats.
Topics: Analgesics; Animals; Bronchi; Bronchoconstriction; Bronchodilator Agents; Capsaicin; Male; Meclofenamic Acid; Muscle Contraction; Muscle Relaxation; Neural Inhibition; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; p-Methoxy-N-methylphenethylamine; Rats; Rats, Inbred F344; Substance P; Trachea | 1997 |
Neurokinin receptors (NK1, NK2) in the mouse: a pharmacological study.
Topics: Animals; In Vitro Techniques; Kinetics; Mice; Mice, Inbred C57BL; Muscle Contraction; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Rabbits; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Stomach; Substance P; Tachykinins; Urinary Bladder | 1997 |
Tachykinin-induced contractions of the guinea pig ileum longitudinal smooth muscle: tonic and phasic muscular activities.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Substance P; Tachykinins | 1997 |
Kinin receptors in the diabetic mouse.
Topics: Acetylcholine; Animals; Bradykinin; Diabetes Mellitus, Experimental; Gastric Fundus; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Neurokinin A; Receptors, Tachykinin; Reference Values; Substance P | 1997 |
Effects of the immunosuppressant cyclosporin A on neurotransmitter release from peripheral non-adrenergic, non-cholinergic nerves.
Topics: Animals; Atropine; Calcium Channel Blockers; Capsaicin; Cyclosporine; Dipeptides; Immunosuppressive Agents; Indoles; Iris; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Rabbits; Sodium Channel Blockers; Substance P | 1997 |
Two novel tachykinin-related peptides from the nervous system of the crab Cancer borealis.
Topics: Amino Acid Sequence; Animals; Brachyura; Ganglia, Invertebrate; Male; Molecular Sequence Data; Muscle Contraction; Neuropeptides; Receptors, Tachykinin; Sequence Homology, Amino Acid; Substance P; Tachykinins | 1997 |
Desensitisation of substance P decreases the contractile effect of M15 and Gal (1-14)-(Abu 8) SCY-I on the rat gastric fundus.
Topics: Animals; Galanin; Gastric Fundus; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Rats; Rats, Wistar; Substance P; Tachykinins; Tachyphylaxis | 1996 |
Tachykinins influence interdigestive rhythm and contractile strength of human small intestine.
Topics: Adult; Dose-Response Relationship, Drug; Female; Gastrointestinal Motility; Humans; Intestine, Small; Male; Manometry; Muscle Contraction; Muscle, Smooth; Myoelectric Complex, Migrating; Neurokinin A; Sodium Chloride; Substance P | 1997 |
Neurokinin A-LI release after antigen challenge in guinea-pig bronchial tubes: influence of histamine and bradykinin.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Bronchi; Capsaicin; Guinea Pigs; Histamine; Histamine H1 Antagonists; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Ovalbumin; Pyrilamine; Substance P; Trachea | 1997 |
In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists.
Topics: Animals; In Vitro Techniques; Iris; Male; Miosis; Muscle Contraction; Muscle, Smooth; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinolines; Rabbits; Receptors, Neurokinin-3; Substance P | 1997 |
Blockade of nitric oxide-evoked smooth muscle contractions by an inhibitor of guanylyl cyclase.
Topics: Animals; Biphenyl Compounds; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; In Vitro Techniques; Intestine, Small; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Nitric Oxide; Signal Transduction; Substance P; Tetrodotoxin | 1997 |
Excitatory and inhibitory actions of pituitary adenylate cyclase-activating peptide (PACAP) in the internal anal sphincter smooth muscle: sites of actions.
Topics: Anal Canal; Animals; Atropine; Guanethidine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neuropeptides; omega-Conotoxin GVIA; Opossums; Peptides; Pituitary Adenylate Cyclase-Activating Polypeptide; Substance P; Tetrodotoxin; Vasoactive Intestinal Peptide | 1997 |
Mechanism of capsaicin-induced relaxation in equine tracheal smooth muscle.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Charybdotoxin; Chymotrypsin; Epithelial Cells; Horses; In Vitro Techniques; Large-Conductance Calcium-Activated Potassium Channels; Methacholine Chloride; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurons, Afferent; Neuropeptides; Nitric Oxide; Nitroarginine; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Substance P; Trachea; Vasoactive Intestinal Peptide | 1997 |
Effect of a novel 5-hydroxytryptamine3 (5-HT3) receptor antagonist, GK-128, on 5-HT3 receptors mediating contractions and relaxations in guinea-pig distal colon.
Topics: Animals; Atropine; Chromones; Colon; Guinea Pigs; Imidazoles; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Substance P | 1997 |
Inhibitory effect of capsaicin on detrusor contractility: further study in the presence of ganglionic blocker and neurokinin receptor antagonist in the rat urinary bladder.
Topics: Administration, Intravesical; Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Electric Stimulation; Ganglionic Blockers; Hexamethonium; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Substance P; Urinary Bladder | 1997 |
KF19514, a phosphodieterase 4 and 1 inhibitor, inhibits PAF-induced lung inflammatory responses by inhaled administration in guinea pigs.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Acetylcholine; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchodilator Agents; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Electric Stimulation; Eosinophils; Guinea Pigs; Muscle Contraction; Muscle, Smooth; Naphthyridines; Neurokinin A; Neutrophils; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Platelet Activating Factor; Pyrrolidinones; Respiratory Therapy; Rolipram; Substance P | 1997 |
Tachykinins may mediate capsaicin-induced, but not vagally induced motility in porcine antrum.
Topics: Animals; Benzamides; Biphenyl Compounds; Capsaicin; Electric Stimulation; Gastrointestinal Motility; Muscle Contraction; Neurokinin A; Neurokinin-1 Receptor Antagonists; Piperidines; Pyloric Antrum; Receptors, Neurokinin-2; Substance P; Swine; Tachykinins; Vagus Nerve | 1997 |
Adenosine reduces airway excitatory non-cholinergic (e-NC) contraction through both A1 and A2 adenosine receptor activation in the guinea pig.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Bronchi; Cholinergic Fibers; Dipyridamole; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Substance P; Theobromine; Vasodilator Agents; Xanthines | 1997 |
Pharmacological characterization of the contractile effects of galanin (1-29)-NH2, galantide and galanin (1-14)-(alpha-aminobutyric acid8)scyliorhinin-I in the rat gastric fundus.
Topics: Acetylcholine; Analgesics; Animals; Calcium Channels; Dose-Response Relationship, Drug; Female; Galanin; Gastric Fundus; Histamine Antagonists; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Pertussis Toxin; Rats; Rats, Wistar; Receptors, Galanin; Receptors, Gastrointestinal Hormone; Sarcoplasmic Reticulum; Substance P; Sympatholytics; Sympathomimetics; Virulence Factors, Bordetella | 1997 |
Response of isolated human neurogenic bladders to tachykinins.
Topics: Adolescent; Atropine; Child; Dose-Response Relationship, Drug; Electric Stimulation; Female; Humans; In Vitro Techniques; Male; Meningomyelocele; Muscle Contraction; Neurokinin A; Neurokinin B; Sacrococcygeal Region; Substance P; Tachykinins; Urinary Bladder, Neurogenic | 1997 |
A role for histamine and substance P in immediate allergic responses in guinea pig airways: characterization of MDL 108,207DA, a dual H1/NK-1 receptor antagonist.
Topics: Animals; Benzimidazoles; Bronchi; Capillary Permeability; CHO Cells; Cricetinae; Dipeptides; Drug Combinations; Guinea Pigs; Histamine; Histamine H1 Antagonists; Indoles; Inositol Phosphates; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Ovalbumin; Pyrilamine; Pyrrolidines; Radioligand Assay; Receptors, Histamine H1; Receptors, Neurokinin-1; Respiratory Hypersensitivity; Skin Tests; Substance P; Trachea; Tumor Cells, Cultured | 1998 |
[Tachykinin receptor subtypes involved in endothelium-dependent and -independent responses in rabbit intrapulmonary arteries].
Topics: Animals; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Pulmonary Artery; Rabbits; Receptors, Tachykinin; Substance P | 1997 |
Effects of prostaglandin E2 on nitric oxide-mediated nonadrenergic noncholinergic relaxations in the guinea-pig tracheal muscle.
Topics: Animals; Autonomic Nervous System; Dinoprostone; Electric Stimulation; Enzyme Inhibitors; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Sodium-Potassium-Exchanging ATPase; Substance P; Trachea | 1998 |
Pharmacology of the peptidomimetic, MEN 11149, a new potent, selective and orally effective tachykinin NK1 receptor antagonist.
Topics: Administration, Oral; Animals; Blood Proteins; Bronchoconstriction; Guinea Pigs; Humans; Ileum; Indoles; Ion Channels; Male; Muscle Contraction; Naphthalenes; Receptors, Tachykinin; Substance P; Tachykinins; Tumor Cells, Cultured | 1998 |
Tachykinin NK2 receptors predominantly mediate tachykinin-induced contractions in ovine trachea.
Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; Female; Muscle Contraction; Neprilysin; Neurokinin A; Receptors, Tachykinin; Sheep; Substance P; Tachykinins; Trachea | 1998 |
Contribution of nitric oxide and substance P to nonadrenergic, noncholinergic transmission in the guinea pig ileum.
Topics: Acetylcholine; Animals; Arginine; Electric Stimulation; Enzyme Inhibitors; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitroarginine; Substance P; Synaptic Transmission; Tetrodotoxin | 1998 |
Activation of non-adrenergic non-cholinergic inhibitory pathways by endogenous and exogenous tachykinins in the ferret lower oesophageal sphincter.
Topics: Animals; Capsaicin; Electric Stimulation; Esophagogastric Junction; Female; Ferrets; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Neurokinin A; Neurokinin-1 Receptor Antagonists; Nitroarginine; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Substance P; Tachykinins; Tetrodotoxin | 1998 |
Substance P stimulates sphincter of Oddi motility and inhibits trans-sphincteric flow in the Australian brush-tailed possum.
Topics: Animals; Australia; Bile; Gallbladder Emptying; Injections, Intra-Arterial; Muscle Contraction; Muscle, Smooth; Nerve Fibers; Neurons; Opossums; Sphincter of Oddi; Substance P; Swine | 1998 |
Comparative, general pharmacology of SDZ NKT 343, a novel, selective NK1 receptor antagonist.
Topics: Animals; Base Sequence; Binding Sites; Cell Line; COS Cells; DNA Primers; Ganglia, Spinal; Gerbillinae; Guinea Pigs; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Naphthalenes; Neurokinin-1 Receptor Antagonists; Proline; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Recombinant Proteins; Substance P | 1998 |
Neurokinin receptors in feline interstitial cystitis.
Topics: Animals; Cat Diseases; Cats; Cystitis, Interstitial; Disease Models, Animal; Iodine Radioisotopes; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Pain; Radiopharmaceuticals; Receptors, Neurokinin-1; Substance P; Tritium | 1998 |
Tachykinin receptors in the small intestine of the cane toad (Bufo marinus): a radioligand binding and functional study.
Topics: Acetylcholine; Amino Acid Sequence; Animals; Bufo marinus; Female; In Vitro Techniques; Intestine, Small; Male; Molecular Sequence Data; Muscle Contraction; Neuropeptides; Radioligand Assay; Receptors, Tachykinin; Substance P; Succinimides; Tachykinins | 1998 |
Neurogenic contraction and relaxation of human penile deep dorsal vein.
Topics: Acetylcholine; Adolescent; Adult; Aged; Electric Stimulation; Endothelium, Vascular; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Norepinephrine; Papaverine; Penis; Substance P; Vasoconstrictor Agents; Vasodilator Agents; Veins | 1998 |
Effect of sodium rhein on electrically-evoked and agonist-induced contractions of the guinea-pig isolated ileal circular muscle.
Topics: Acetylcholine; Animals; Anthraquinones; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Reflex; Substance P; Synaptic Transmission | 1998 |
BMS-181885, a 5-HT1B/1D receptor ligand, in experimental models predictive of antimigraine activity and coronary side-effect potential.
Topics: Animals; Arteriovenous Anastomosis; Carotid Arteries; Coronary Vessels; Hemodynamics; Humans; In Vitro Techniques; Indoles; Jugular Veins; Migraine Disorders; Muscle Contraction; Muscle, Smooth, Vascular; Oxygen; Piperazines; Potassium; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin Receptor Agonists; Substance P; Sumatriptan; Swine; Vasoconstrictor Agents | 1998 |
In vivo signal transduction of tetrodotoxin-sensitive nociceptive responses by substance P given into the planta of the mouse hind limb.
Topics: Action Potentials; Afferent Pathways; Animals; Biphenyl Compounds; Calcium Signaling; Egtazic Acid; Estrenes; GTP-Binding Proteins; Hindlimb; Inositol 1,4,5-Trisphosphate; Ion Transport; Male; Mice; Mice, Inbred Strains; Models, Neurological; Muscle Contraction; Neurons, Afferent; Neurotoxins; Nociceptors; Phosphatidylinositol Diacylglycerol-Lyase; Phosphodiesterase Inhibitors; Pyrrolidinones; Receptors, Neurokinin-1; Reflex; Signal Transduction; Substance P; Tetrodotoxin; Type C Phospholipases | 1998 |
Purification, characterization, and spasmogenic activity of neurotensin from the toad Bufo marinus.
Topics: Acetylcholine; Amino Acid Sequence; Animals; Atropine; Bufo marinus; Cattle; Chromatography, High Pressure Liquid; Humans; In Vitro Techniques; Indomethacin; Intestine, Small; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Neurotensin; Sequence Analysis; Substance P; Tetrodotoxin | 1998 |
Nociceptin inhibits non-adrenergic non-cholinergic contraction in guinea-pig airway.
Topics: Animals; Bronchi; Capsaicin; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neuropeptides; Nociceptin; Opioid Peptides; Receptors, Opioid; Substance P | 1998 |
Action of substance P and interaction of calcitonin gene-related peptide and substance P on the cat antral circular muscle.
Topics: Animals; Atropine; Autoradiography; Biphenyl Compounds; Calcitonin Gene-Related Peptide; Cats; Colon; Immunohistochemistry; Muscle Contraction; Protein Binding; Pyloric Antrum; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tetrodotoxin | 1998 |
ATP-sensitive K+ current and its modulation by substance P in gastric myocytes isolated from guinea pig.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Barium; Cesium; Cromakalim; Female; Glyburide; Guinea Pigs; Hypoglycemic Agents; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Patch-Clamp Techniques; Potassium; Potassium Channels; Pyloric Antrum; Substance P; Tetraethylammonium; Vasodilator Agents | 1998 |
Effect of ONO-1078, a leukotriene antagonist, on capsaicin- and substance P-induced bronchoconstriction and airway microvascular leakage in guinea pigs.
Topics: Animals; Bronchi; Bronchoconstriction; Capsaicin; Chromones; Female; Guinea Pigs; In Vitro Techniques; Leukotriene C4; Male; Muscle Contraction; Muscle, Smooth; Substance P | 1996 |
Inflammatory and motor responses by tachykinins in the guinea-pig oesophageal sphincter.
Topics: Animals; Dipeptides; Diphenhydramine; Dose-Response Relationship, Drug; Esophagogastric Junction; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Guinea Pigs; Indoles; Inflammation; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P | 1998 |
A substance P receptor antagonist (FK 888) modifies gut alterations induced by ionizing radiation.
Topics: Animals; Dipeptides; Ileum; Indoles; Intestinal Mucosa; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Rats; Rats, Wistar; Substance P | 1998 |
Mechanisms and sites of action of endothelins 1 and 2 on the opossum internal anal sphincter smooth muscle tone in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic Agents; Anal Canal; Animals; Atropine; Calcium Channel Blockers; Calmodulin; Cyclooxygenase Inhibitors; Endothelin-1; Endothelin-2; Enzyme Inhibitors; Guanethidine; In Vitro Techniques; Indomethacin; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Nitric Oxide Synthase; Nitroarginine; omega-Conotoxin GVIA; Opossums; Peptides; Polymethacrylic Acids; Protein Kinase C; Substance P; Sulfonamides; Tachyphylaxis; Tetrodotoxin | 1999 |
Cholinergic stimulation and nonadrenergic, noncholinergic relaxation of human colonic circular muscle in idiopathic chronic constipation.
Topics: Acetylcholine; Adenosine Triphosphate; Adult; Atropine; Cholinergic Fibers; Chronic Disease; Colon; Constipation; Electric Stimulation; Gastrointestinal Motility; Guanethidine; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Substance P; Vasoactive Intestinal Peptide | 1998 |
Skeletal muscle afferent fibres release substance P in the nucleus tractus solitarii of anaesthetized cats.
Topics: Anesthesia; Animals; Blood Pressure; Cats; Female; Heart Rate; Hemodynamics; Male; Microdialysis; Muscle Contraction; Muscle, Skeletal; Nerve Fibers; Neurons, Afferent; Physical Stimulation; Radioimmunoassay; Solitary Nucleus; Substance P | 1999 |
A role of peptidergic nerves in the internal anal sphincter of Hirschsprung's disease.
Topics: Aged; Anal Canal; Atropine; Electric Stimulation; Female; Ganglia, Autonomic; Gastrointestinal Motility; Hirschsprung Disease; Humans; In Vitro Techniques; Infant; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Phenoxybenzamine; Propranolol; Rectal Neoplasms; Substance P; Tetrodotoxin; Vasoactive Intestinal Peptide | 1999 |
Progression from homologous to heterologous desensitization of contraction in gastric smooth muscle cells.
Topics: Animals; Calcium; Cells, Cultured; Cholecystokinin; Gastrin-Releasing Peptide; Guinea Pigs; Inositol Phosphates; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Neuropeptides; Sensitivity and Specificity; Stomach; Substance P | 1999 |
Sites of actions of contractile and relaxant effects of pituitary adenylate cyclase activating peptide (PACAP) in the internal anal sphincter smooth muscle.
Topics: Anal Canal; Animals; Apamin; Electric Stimulation; Female; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Myenteric Plexus; Neuropeptides; omega-Conotoxin GVIA; Opossums; Peptides; Pituitary Adenylate Cyclase-Activating Polypeptide; Substance P; Tetrodotoxin; Vasoactive Intestinal Peptide | 1998 |
SR140333, a substance P receptor antagonist, influences morphological and motor changes in rat experimental colitis.
Topics: Animals; Colitis; Colon; Inflammation; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Substance P; Trinitrobenzenesulfonic Acid | 1999 |
Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 2. Identification of (S)-N-(1-phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide (SB 223412).
Topics: Animals; Calcium; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Humans; In Vitro Techniques; Iris; Mice; Miosis; Motor Activity; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Quinolines; Rabbits; Radioligand Assay; Receptors, Neurokinin-3; Structure-Activity Relationship; Substance P | 1999 |
Pharmacological evidence that neuropeptides mediate part of the actions of scorpion venom on the guinea pig ileum.
Topics: Animals; Atropine; Biphenyl Compounds; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Isoindoles; Muscarinic Antagonists; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Neuropeptides; Scorpion Venoms; Stereoisomerism; Substance P | 1999 |
Role of neurokinin 3 receptors on responses to colorectal distention in the rat: electrophysiological and behavioral studies.
Topics: Animals; Colon; Electromyography; Gastrointestinal Motility; Injections, Intraperitoneal; Injections, Intraventricular; Male; Muscle Contraction; Pain Measurement; Peptide Fragments; Piperidines; Pressure; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Neurokinin-3; Rectum; Sensory Thresholds; Substance P; Visceral Afferents | 1999 |
Limitations in using peptide drugs to characterize calcitonin gene-related peptide receptors.
Topics: Animals; Basilar Artery; Calcitonin Gene-Related Peptide; Capsaicin; Coronary Vessels; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Peptide Fragments; Potassium Chloride; Receptors, Calcitonin Gene-Related Peptide; Reproducibility of Results; Substance P; Swine; Vasodilation | 1999 |
The tachykinins neurokinin A and substance P, but not neurokinin B, stimulate contraction of isolated muscle cells from rat small intestine.
Topics: Animals; Dose-Response Relationship, Drug; Gastrointestinal Motility; Intestine, Small; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Smooth; Neurokinin A; Neurokinin B; Rats; Substance P | 1999 |
Cyclic pentapeptides of chiral sequence DLDDL as scaffold for antagonism of G-protein coupled receptors: synthesis, activity and conformational analysis by NMR and molecular dynamics of ITF 1565 a substance P inhibitor.
Topics: Animals; Aorta; GTP-Binding Proteins; Guinea Pigs; Ileum; In Vitro Techniques; Indicators and Reagents; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Protein Conformation; Pulmonary Artery; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Venae Cavae | 1999 |
Pharmacologic characteristics of non-prostanoid, non-nitric oxide mediated and endothelium-dependent relaxation of guinea-pig aorta in response to substance P.
Topics: Aging; Animals; Animals, Newborn; Aorta, Thoracic; Endothelium, Vascular; Epoprostenol; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Nitric Oxide; Norepinephrine; Potassium Channel Blockers; Substance P | 1999 |
Substance P and bradykinin activate different types of KCa currents to hyperpolarize cultured porcine coronary artery endothelial cells.
Topics: Algorithms; Animals; Apamin; Bradykinin; Cells, Cultured; Coronary Vessels; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Fluorescent Dyes; Fura-2; Intermediate-Conductance Calcium-Activated Potassium Channels; Membrane Potentials; Microelectrodes; Muscle Contraction; Oxygenases; Patch-Clamp Techniques; Peptides; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Substance P; Swine | 1999 |
Interleukin-1beta-induced hyperresponsiveness to [Sar9,Met(O2)11]substance P in isolated human bronchi.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aged; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Bronchi; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Hypersensitivity; Female; Heptanoic Acids; Humans; In Vitro Techniques; Indans; Indomethacin; Interleukin-1; Male; Muscle Contraction; Muscle, Smooth; Prostaglandin Antagonists; Receptors, Tachykinin; Substance P; Thromboxane B2; Time Factors; Vasoconstrictor Agents | 1999 |
An immunohistochemical and pharmacological study of tachykinins in the rat and guinea-pig prostate glands.
Topics: Animals; Atropine; Benzamides; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Immunohistochemistry; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Peptide Fragments; Piperidines; Prostate; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Substance P; Tachykinins | 1999 |
Progressive alterations in circular smooth muscle contractility in TNBS-induced colitis in rats.
Topics: Acetylcholine; Animals; Atropine; Colitis; Dose-Response Relationship, Drug; Gastrointestinal Motility; Hexamethonium; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Nicotinic Antagonists; Parasympatholytics; Potassium Chloride; Rats; Rats, Sprague-Dawley; Substance P; Tetrodotoxin; Trinitrobenzenesulfonic Acid; Vasodilator Agents | 1999 |
The importance of C-terminal residues of vertebrate and invertebrate tachykinins for their contractile activities in gut tissues.
Topics: Amino Acid Substitution; Animals; Arginine; Cockroaches; Guinea Pigs; Helminth Proteins; Male; Methionine; Muscle Contraction; Neurokinin A; Neurokinin B; Neuropeptides; Species Specificity; Substance P | 1999 |
Intestinal motor depression by 7-nitroindazole through an action unrelated to nitric oxide synthase inhibition.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gastrointestinal Motility; Guinea Pigs; Imidazoles; In Vitro Techniques; Indazoles; Indomethacin; Intestine, Small; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptide Fragments; Peristalsis; Sincalide; Substance P; Tetrodotoxin | 1999 |
Inhibitory effect of capsaicin on cholinergic transmission in ovine airways: evidence for non-cholinergic contractions.
Topics: Acetylcholine; Animals; Capsaicin; Carbachol; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Lung; Muscle Contraction; Muscle, Smooth; Neural Inhibition; Neurokinin-1 Receptor Antagonists; Neuromuscular Junction; Peptides, Cyclic; Quinuclidines; Receptors, Drug; Receptors, Neurokinin-2; Serotonin; Sheep; Substance P; Synaptic Transmission; Trachea | 1999 |
Endothelium-dependent relaxation followed by contraction mediated by NK(1) receptors in precontracted rabbit intrapulmonary arteries.
Topics: Animals; Benzamides; Benzoquinones; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Lipoxygenase Inhibitors; Male; Muscle Contraction; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Piperidines; Pulmonary Artery; Rabbits; Receptors, Neurokinin-1; Substance P | 2000 |
Characteristics of post-tetanic contraction induced by naloxone in guinea pig ileum.
Topics: Acetylcholine; Animals; Atropine; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle Contraction; Naloxone; Narcotic Antagonists; Nerve Block; Substance P; Tetrodotoxin; Vasodilator Agents | 2000 |
Evidence for the involvement of ATP, but not of VIP/PACAP or nitric oxide, in the excitatory effect of capsaicin in the small intestine.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Capsaicin; Enzyme Inhibitors; Guinea Pigs; Ileum; In Vitro Techniques; Intestine, Small; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Neuropeptides; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Physalaemin; Piperidines; Pituitary Adenylate Cyclase-Activating Polypeptide; Pyridoxal Phosphate; Receptors, Neurokinin-3; Sincalide; Substance P; Vasoactive Intestinal Peptide | 2000 |
Lipopolysaccharide-induced lung injury in mice. II. Evaluation of functional damage in isolated parenchyma strips.
Topics: Animals; Anti-Inflammatory Agents; Betamethasone; Bradykinin; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Female; Histamine; Lipopolysaccharides; Lung Diseases; Methacholine Chloride; Mice; Muscle Contraction; Pentoxifylline; Serotonin; Substance P | 2000 |
Mechanisms mediating substance P-induced contraction in the rat iris in vitro.
Topics: Animals; Calcium; Calcium Channels; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Enzyme Inhibitors; Iris; Male; Muscle Contraction; Muscle, Smooth; Pharmacology; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P | 2000 |
Differences in circular muscle contraction and peristaltic motor inhibition caused by tachykinin NK1 receptor agonists in the guinea-pig small intestine.
Topics: Adenosine Triphosphate; Animals; Enzyme Inhibitors; Female; Guinea Pigs; Intestine, Small; Male; Motor Neurons; Muscle Contraction; Muscle, Smooth; Neurokinin A; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Peristalsis; Piperidines; Purinergic P2 Receptor Antagonists; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Sincalide; Spasm; Substance P; Suramin; Tetrodotoxin | 2000 |
Leukaemia inhibitory factor (LIF) upregulates excitatory non-adrenergic non-cholinergic and maintains cholinergic neural function in tracheal explants.
Topics: Animals; Carbachol; Growth Inhibitors; Guinea Pigs; Interleukin-6; Leukemia Inhibitory Factor; Lymphokines; Muscle Contraction; Neutrophils; Receptor, Muscarinic M2; Receptors, Cytokine; Receptors, Muscarinic; Receptors, OSM-LIF; Substance P; Trachea | 2000 |
Human isolated coronary artery contraction to sumatriptan characterised by the selective 5-HT1B/1D receptor antagonist GR55562.
Topics: Benzamides; Coronary Vessels; Dinoprost; Dose-Response Relationship, Drug; Drug Interactions; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Potassium; Pyridines; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Substance P; Sumatriptan; Vasoconstrictor Agents | 2000 |
Effects of amylin and other peptide hormones on Na+-K+ transport and contractility in rat skeletal muscle.
Topics: Adrenomedullin; Amyloid; Animals; Biological Transport, Active; C-Peptide; Cyclic AMP; Insulin; Islet Amyloid Polypeptide; Muscle Contraction; Muscle, Skeletal; Neuropeptides; Ouabain; Peptides; Potassium; Rats; Rats, Wistar; Sodium; Sodium-Potassium-Exchanging ATPase; Substance P; Theophylline | 2000 |
Mechanisms underlying the reduced endothelium-dependent relaxation in human omental resistance artery in pre-eclampsia.
Topics: Adult; Benzimidazoles; Bradykinin; Calcium; Calcium Channel Agonists; Cyclic GMP; Cyclooxygenase Inhibitors; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Omentum; Potassium; Pre-Eclampsia; Pregnancy; Substance P; Thromboxane A2; Vasodilation | 2000 |
Dose-dependent effects of recombinant human interleukin-11 on contractile properties in rabbit 2,4,6-trinitrobenzene sulfonic acid colitis.
Topics: Acetylcholine; Animals; Colitis; Colon; Dinoprostone; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Interleukin-11; Male; Motilin; Muscle Contraction; Muscle, Smooth; Potassium Chloride; Rabbits; Receptors, Gastrointestinal Hormone; Receptors, Neurokinin-1; Receptors, Neuropeptide; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Substance P; Tensile Strength; Trinitrobenzenesulfonic Acid | 2000 |
Lack of effect of nitric oxide on KCl, acetylcholine and substance P induced contractions in ileal longitudinal muscle of the rat.
Topics: Acetylcholine; Animals; Ileum; In Vitro Techniques; Indoles; Muscle Contraction; Nifedipine; Nitric Oxide; Nitric Oxide Donors; Potassium Chloride; Rats; Rats, Sprague-Dawley; Substance P | 2000 |
Effect of galanin and galanin antagonists on peristalsis in esophageal smooth muscle in the opossum.
Topics: Animals; Atropine; Deglutition; Electric Stimulation; Esophagus; Galanin; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Opossums; Peristalsis; Substance P; Vagus Nerve | 2000 |
Evidence that PAR-1 and PAR-2 mediate prostanoid-dependent contraction in isolated guinea-pig gallbladder.
Topics: Animals; Caenorhabditis elegans Proteins; Dose-Response Relationship, Drug; Gallbladder; Guinea Pigs; Helminth Proteins; Humans; In Vitro Techniques; Indomethacin; Male; Mice; Muscle Contraction; Prostaglandins; Protein Serine-Threonine Kinases; Substance P; Thrombin | 2000 |
Mechanism of delayed gastric emptying in naturally occurring CCK-A receptor gene knockout (OLETF) rats.
Topics: Animals; Carbachol; Cholinergic Agonists; Gastric Emptying; Gene Expression; Male; Muscle Contraction; Muscle, Smooth; Nitroprusside; Norepinephrine; Rats; Rats, Inbred OLETF; Rats, Mutant Strains; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Receptors, G-Protein-Coupled; Receptors, Gastrointestinal Hormone; RNA, Messenger; Stomach; Substance P; Vasodilator Agents | 2000 |
Tachykinin-induced contraction of the guinea-pig isolated oesophageal mucosa is mediated by NK(2) receptors.
Topics: Animals; Benzamides; Captopril; Dose-Response Relationship, Drug; Esophagus; Guinea Pigs; In Vitro Techniques; Mucous Membrane; Muscle Contraction; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Protease Inhibitors; Quinolines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins; Thiorphan | 2000 |
Effects of natural tachykinins on porcine lower urinary tract smooth muscle.
Topics: Animals; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Swine; Urinary Bladder | 2000 |
Tachykinins contribute to nerve-mediated contractions in the human esophagus.
Topics: Atropine; Autonomic Nervous System; Benzamides; Dose-Response Relationship, Drug; Esophagus; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Parasympatholytics; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Substance P; Tachykinins | 2001 |
Tachykinin NK(2) receptor mediates contraction and ion transport in rat colon by different mechanisms.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colon; Indomethacin; Intestinal Mucosa; Ion Transport; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Rats; Rats, Wistar; Receptors, Neurokinin-2; Substance P | 2001 |
Differential alterations in tachykinin NK2 receptors in isolated colonic circular smooth muscle in inflammatory bowel disease and idiopathic chronic constipation.
Topics: Adult; Aged; Aged, 80 and over; Carbachol; Cholinergic Agonists; Chronic Disease; Colon; Constipation; Female; Humans; Inflammatory Bowel Diseases; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P | 2001 |
Effects of oophorectomy on functional properties of resistance arteries isolated from the cancellous bone of the rabbit femur.
Topics: Acetylcholine; Animals; Arteries; Bradykinin; Dose-Response Relationship, Drug; Drug Interactions; Endothelin-1; Female; Femur; Muscle Contraction; Muscle, Smooth, Vascular; Myography; Norepinephrine; Ovariectomy; Potassium; Rabbits; Substance P; Vasoconstrictor Agents; Vasodilator Agents; Vasopressins | 2001 |
Chemo-enzymatic synthesis of a bioactive peptide containing a glutamine-linked oligosaccharide and its characterization.
Topics: Amidohydrolases; Amino Acid Sequence; Animals; Carbohydrate Sequence; Glutamine; Glycosylation; Guinea Pigs; Ileum; Models, Chemical; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Oligosaccharides; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase; Substance P | 2001 |
Mechanism of atropine-resistant contraction induced by Dai-kenchu-to in guinea pig ileum.
Topics: Animals; Atropine; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Panax; Pharmaceutical Preparations; Plant Extracts; Substance P; Zanthoxylum; Zingiberaceae | 2001 |
Cocaine toxic effect on endothelium-dependent vasorelaxation: an in vitro study on rabbit aorta.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Calcimycin; Cocaine; Drug Interactions; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitroprusside; Phenylephrine; Rabbits; Substance P; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2001 |
[Synthesis and biological activity of substance P analogs].
Topics: Animals; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Substance P | 1997 |
Endothelin-1 increases cholinergic nerve-mediated contraction of human bronchi via tachykinin synthesis induction.
Topics: Acetylcholine; Aged; Benzamides; Bronchi; Cholinergic Fibers; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electric Stimulation; Endothelin-1; Female; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Neurokinin A; Piperidines; Protein Precursors; Radioimmunoassay; Receptors, Neurokinin-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Tachykinins; Vasodilator Agents | 2001 |
Mechanisms of cholinergic dysfunction in rabbits following recurrent aspiration of cow's milk.
Topics: Acetylcholine; Animals; Choline O-Acetyltransferase; Electric Stimulation; Immunohistochemistry; In Vitro Techniques; Milk; Muscle Contraction; Muscle, Smooth; Pneumonia, Aspiration; Rabbits; Recurrence; Respiratory Mechanics; Substance P; Trachea | 2001 |
Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs.
Topics: Acetates; Animals; Antitussive Agents; Behavior, Animal; Bronchial Hyperreactivity; Calcium; Central Nervous System; Citric Acid; Cloning, Molecular; Cough; Guinea Pigs; In Vitro Techniques; Iris; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Pupil; Quinolines; Rabbits; Radioligand Assay; Rats; Receptors, Neurokinin-3; Receptors, Tachykinin; Recombinant Proteins; Substance P | 2002 |
Effects of intestinal ischemia on in vitro activity of adjacent jejunum in samples obtained from ponies.
Topics: Animals; Choline O-Acetyltransferase; Dopamine beta-Hydroxylase; Electric Stimulation; Horse Diseases; Horses; Immunohistochemistry; In Vitro Techniques; Ischemia; Jejunum; Muscle Contraction; Muscle, Smooth; Nitric Oxide Synthase; Norepinephrine; Potassium Chloride; Substance P | 2001 |
Mechanism of the contractile effects of galantide and Galanin(1-14) [alpha-aminobutyric acid]scyliorhinin-I in rat isolated fundus strips.
Topics: Animals; Binding Sites; Cold Temperature; Dose-Response Relationship, Drug; Galanin; Gastric Mucosa; Muscle Contraction; Muscle, Smooth; Peptides; Rats; Rats, Wistar; Receptors, Tachykinin; Substance P | 2002 |
A new nonpeptide tachykinin NK1 receptor antagonist isolated from the plants of Compositae.
Topics: Alkenes; Animals; Asteraceae; Aza Compounds; Binding, Competitive; Chamomile; CHO Cells; Cricetinae; Guinea Pigs; Humans; Ileum; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Plant Extracts; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P; Tachykinins | 2002 |
Purification, characterization, and biological activity of a substance P-related peptide from the gut of the Australian lungfish, Neoceratodus forsteri.
Topics: Acetylcholine; Animals; Chromatography, High Pressure Liquid; Digestive System; Female; Fishes; Gastrointestinal Motility; Male; Muscle Contraction; Muscle, Smooth; Radioimmunoassay; Substance P | 2002 |
Effect of tachykinins on ascending and descending reflex pathway in rat small intestine.
Topics: Afferent Pathways; Animals; Biphenyl Compounds; Efferent Pathways; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Physalaemin; Rats; Rats, Wistar; Reaction Time; Receptors, Neurokinin-2; Reflex; Substance P; Tachykinins | 2002 |
Effect of cationic peptides on rat ileum muscle contraction and histamine release from rat peritoneal mast cells.
Topics: Animals; Benzalkonium Compounds; Bradykinin; Cations; Histamine Release; Ileum; Kallidin; Male; Mast Cells; Muscle Contraction; Muscle, Smooth; Peptides; Peritoneal Cavity; Rats; Rats, Wistar; Substance P | 2002 |
Effects of nimesulide and pentoxifylline on decreased contractile responses in rat ileum with peritonitis.
Topics: Animals; Carbachol; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ileum; In Vitro Techniques; Male; Muscle Contraction; Pentoxifylline; Peritonitis; Phosphodiesterase Inhibitors; Potassium Chloride; Rats; Rats, Wistar; Substance P; Sulfonamides | 2002 |
Effect of L-NAME on decreased ileal muscle contractility induced by peritonitis in rats.
Topics: Animals; Carbachol; Dose-Response Relationship, Drug; Gastrointestinal Motility; Ileum; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peritonitis; Potassium Chloride; Rats; Rats, Wistar; Substance P | 2002 |
Substance P release in the feline nucleus tractus solitarius during ergoreceptor but not baroreceptor afferent signaling.
Topics: Afferent Pathways; Animals; Baroreflex; Cardiovascular Physiological Phenomena; Cats; Mechanoreceptors; Movement; Muscle Contraction; Muscle Fatigue; Muscle, Skeletal; Neural Inhibition; Neurokinin-1 Receptor Antagonists; Neurons; Physalaemin; Pressoreceptors; Receptors, Neurokinin-1; Solitary Nucleus; Substance P; Sympathetic Nervous System | 2002 |
The effects of metoclopramide in modifying the response of isolated guinea-pig ileum to various agonists.
Topics: Acetylcholine; Animals; Atropine; Barium; Female; Guanethidine; Guinea Pigs; Histamine; Hydrogen-Ion Concentration; Ileum; In Vitro Techniques; Male; Metoclopramide; Muscle Contraction; Muscle, Smooth; Pimozide; Substance P; Tetrodotoxin | 1976 |
Substance P: binding to lipids in the brain.
Topics: Animals; Blood Pressure; Brain; Brain Stem; Cattle; Chromatography, Thin Layer; Hydrogen-Ion Concentration; Lipid Metabolism; Muscle Contraction; Rats; Salivation; Substance P | 1978 |
The character of the antagonism by polyphloretin phosphate of contractions to prostaglandins E1 and F 2alpha in guinea-pig ileum.
Topics: Acetylcholine; Animals; Barium; Drug Interactions; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Phloretin; Polyphloretin Phosphate; Prostaglandins E; Prostaglandins F; Serotonin; Substance P | 1978 |
The effects of some analgesic and neuroleptic drugs on the spasmogenic actions of substance P on guinea-pig ileum.
Topics: Analgesics; Animals; Antipsychotic Agents; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Substance P; Time Factors | 1978 |
Substance P: model studies of its binding to phospholipids.
Topics: Animals; Cations; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Models, Biological; Muscle Contraction; Phospholipids; Substance P | 1979 |
Longitudinal contraction of isolated guinea-pig ileum induced by rapid cooling.
Topics: Animals; Capsaicin; Cold Temperature; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Serotonin; Substance P; Tachyphylaxis; Temperature | 1979 |
Effects of intra-arterial bradykinin and substance P on isolated, blood-perfused small intestine of the rat.
Topics: Animals; Blood; Bradykinin; Hexamethonium Compounds; Ileum; In Vitro Techniques; Injections, Intra-Arterial; Male; Morphine; Muscle Contraction; Muscle, Smooth; Perfusion; Rats; Substance P; Tetrodotoxin | 1979 |
Synthesis of substance P analogs and agonistic and antagonistic activities.
Topics: Animals; Biological Assay; Guinea Pigs; Ileum; Methods; Muscle Contraction; Structure-Activity Relationship; Substance P | 1979 |
Centrally administered neurotensin: activity in the Julou-Courvoisier muscle relaxation test in mice.
Topics: Animals; Bradykinin; Cisterna Magna; In Vitro Techniques; Injections; Male; Mice; Muscle Contraction; Muscle Relaxation; Neurotensin; Substance P; Thyrotropin-Releasing Hormone; Time Factors | 1979 |
Pharmacologic characterization of isolated rhesus monkey bronchial smooth muscle.
Topics: Acetylcholine; Animals; Atropine; Bronchi; Bronchodilator Agents; Carbachol; Dose-Response Relationship, Drug; Haplorhini; Macaca mulatta; Male; Muscle Contraction; Muscle, Smooth; Propranolol; Prostaglandins F; Substance P | 1979 |
Effect of enkephalin and substance P on sympathetic nerve transmission in mouse vas deferens.
Topics: Animals; Electric Stimulation; Endorphins; Enkephalins; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Norepinephrine; Potassium; Substance P; Sympathetic Nervous System; Synaptic Transmission; Vas Deferens | 1978 |
Evidence for the release of endogenous substance P from intestinal nerves.
Topics: Animals; Binding Sites; Female; Guinea Pigs; In Vitro Techniques; Intestinal Mucosa; Intestines; Male; Muscle Contraction; Neurons; Scopolamine; Substance P; Synaptic Transmission | 1979 |
In vivo studies of individual mucous glands in the frog.
Topics: Animals; Anura; Electric Stimulation; Epithelial Cells; Epithelium; Exocrine Glands; Mucus; Muscle Contraction; Muscle, Smooth; Rana esculenta; Rana temporaria; Substance P; Sympathetic Nervous System; Xenopus | 1977 |
Effects of neuronal polypeptides on intestinal smooth muscle; a comparison with non-adrenergic, non-cholinergic nerve stimulation and ATP.
Topics: Adenosine Triphosphate; Animals; Electric Stimulation; Enkephalins; Female; Guinea Pigs; In Vitro Techniques; Indomethacin; Intestines; Male; Muscle Contraction; Muscle, Smooth; Neurotensin; Peptides; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 1979 |
[A study on the biological action of hypothalamic tridecapeptide, neurotensin (author's transl)].
Topics: Animals; Blood Pressure; Bradykinin; Castration; Duodenum; Estrogens; Female; Follicle Stimulating Hormone; Guinea Pigs; Ileum; In Vitro Techniques; Luteinizing Hormone; Muscle Contraction; Neurotensin; Progesterone; Prolactin; Rats; Substance P; Uterine Contraction | 1979 |
The interaction of enkephalins with substance P on vascular smooth muscle.
Topics: Animals; Aorta; Drug Interactions; Endorphins; Enkephalins; Female; In Vitro Techniques; Morphine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Norepinephrine; Rabbits; Substance P | 1979 |
An attempt to differentiate the effects of angiotensin II, substance P and bradykinin on the field-stimulated guinea-pig vas deferens.
Topics: Angiotensin II; Animals; Bradykinin; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Oligopeptides; Saralasin; Substance P; Vas Deferens | 1979 |
A cholecystokinin-like peptide in crude substance P from human and bovine brain.
Topics: Animals; Biological Assay; Brain Chemistry; Cattle; Cholecystokinin; Gallbladder; Guinea Pigs; Humans; Ileum; Immunoglobulin Fc Fragments; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Peptides; Radioimmunoassay; Substance P; Vas Deferens | 1979 |
Studies on peptides. LXXXI. Application of a new arginine derivative, NG-mesitylene-2-sulfonylarginine, to the synthesis of substance P and neurotensin.
Topics: Amino Acid Sequence; Animals; Arginine; Muscle Contraction; Muscle, Smooth; Neurotensin; Peptide Fragments; Rabbits; Substance P | 1979 |
In vitro activities of some synthetic substance P analogs.
Topics: Animals; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Structure-Activity Relationship; Substance P | 1979 |
The actions of some vasoactive polypeptides and their antagonists on the anococcygeus muscle.
Topics: Animals; Bradykinin; Cats; Eledoisin; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Rabbits; Rats; Substance P | 1978 |
Studies on peptides. LXXVI. Synthesis of kassinin, a new frog skin peptide.
Topics: Amino Acid Sequence; Animals; Anura; Guinea Pigs; Ileum; Muscle Contraction; Oligopeptides; Skin; Substance P | 1978 |
Potentiation by substance P of contractions of the isolated vas deferens of the mouse elicited by electric field stimulation and by drugs.
Topics: Animals; Drug Synergism; Electric Stimulation; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Norepinephrine; Substance P; Vas Deferens | 1978 |
The rabbit mesenteric vein: a specific bioassay for substance P.
Topics: Animals; Cats; Dogs; Drug Interactions; Guinea Pigs; In Vitro Techniques; Mesenteric Veins; Muscle Contraction; Muscle, Smooth; Rabbits; Rats; Substance P; Time Factors | 1978 |
Crude substance P from brain contains a cholecystokinin-like peptide.
Topics: Animals; Brain Chemistry; Chemical Phenomena; Chemistry; Cholecystokinin; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Peptides; Radioimmunoassay; Substance P | 1978 |
A selective tonic activation of gastrointestinal smooth muscle by substance P.
Topics: Animals; Calcium; Female; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Organ Specificity; Stomach; Substance P | 1978 |
Substance P and opioid interaction on stimulated and non-stimulated guinea pig ileum.
Topics: Animals; Atropine; Drug Interactions; Electric Stimulation; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotics; Substance P | 1978 |
Relationship of spasmogenic and smooth muscle relaxant peptides from normal lung to other vasoactive compounds.
Topics: Angiotensin II; Animals; Bradykinin; Cross Reactions; Lung; Muscle Contraction; Muscle, Smooth; Peptides; Prostaglandins; Substance P; Swine; Vasoactive Intestinal Peptide; Vasodilator Agents | 1977 |
Interactions between local anesthetics and spasmogens on the guinea-pig ileum.
Topics: Acetylcholine; Anesthetics, Local; Animals; Barium; Calcium; Drug Interactions; Female; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Lanthanum; Male; Muscle Contraction; Muscle, Smooth; Substance P; Verapamil | 1976 |
Studies on peptides. LVIII. Synthesis of Tyr1-substance P.
Topics: Animals; Guinea Pigs; In Vitro Techniques; Methods; Muscle Contraction; Muscle, Smooth; Radioimmunoassay; Substance P | 1976 |
Effect of substance P on various vascular beds in the dog.
Topics: Animals; Aorta; Blood Pressure; Carotid Arteries; Depression, Chemical; Dogs; Femoral Artery; Hepatic Artery; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth; Portal Vein; Regional Blood Flow; Renal Artery; Stimulation, Chemical; Substance P; Vascular Resistance | 1975 |
Neurokinin A-stimulated phosphoinositide breakdown in rabbit iris sphincter muscle.
Topics: Animals; Atropine; Binding, Competitive; Calcium; Female; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Neurokinin A; Oculomotor Muscles; Phosphatidylinositols; Rabbits; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1992 |
Involvement of opioid mechanisms in peripheral motor control of detrusor muscle.
Topics: Animals; Electric Stimulation; Enkephalins; Ganglionic Blockers; Hexamethonium; Hexamethonium Compounds; Humans; Indoles; Male; Morphinans; Morphine; Muscle Contraction; Muscles; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance P; Sympatholytics | 1992 |
Effect of substance P on detrusor muscle in rats with diabetic cystopathy.
Topics: Animals; Diabetes Mellitus, Experimental; Muscle Contraction; Muscles; Pressure; Rats; Rats, Sprague-Dawley; Substance P; Urinary Bladder; Urinary Bladder Diseases; Urination; Urodynamics | 1992 |
CP-96,345 antagonism of NK1 receptors and smoke-induced protein extravasation in relation to its cardiovascular effects.
Topics: Animals; Biphenyl Compounds; Blood Proteins; Extravasation of Diagnostic and Therapeutic Materials; Guinea Pigs; Hemodynamics; Injections, Intravenous; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Nicotiana; Plants, Toxic; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Receptors, Tachykinin; Smoke; Substance P; Swine; Trachea | 1992 |
[Pro9]SP and [pGlu6, Pro9]SP(6-11) interact with two different receptors in the guinea-pig ileum as demonstrated with new SP antagonists.
Topics: Amino Acid Sequence; Animals; Brain Chemistry; Duodenum; Guinea Pigs; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Neurokinin A; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Synaptosomes | 1992 |
Possible regulatory role of dynorphin A in the urinary bladder.
Topics: Analgesics; Animals; Child; Dynorphins; Electric Stimulation; Female; Fluorescent Antibody Technique; Ganglia; Humans; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscles; Naloxone; Narcotics; Nerve Fibers; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Substance P; Urinary Bladder | 1992 |
Characterisation of NK receptors in guinea-pig urinary bladder smooth muscle: use of selective antagonists.
Topics: Animals; Biphenyl Compounds; Guinea Pigs; Hypnotics and Sedatives; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Urinary Bladder | 1992 |
A pharmacological study of NK1 and NK2 tachykinin receptor characteristics in the rat isolated urinary bladder.
Topics: Animals; Carbachol; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Rats; Rats, Wistar; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Urinary Bladder | 1992 |
Blockade of electrical field stimulation-induced nonadrenergic noncholinergic (NANC) excitatory response of the guinea pig ileum.
Topics: Animals; Autonomic Nervous System; Electric Stimulation; Female; Guinea Pigs; Histamine H1 Antagonists; Ileum; Male; Muscle Contraction; Muscle, Smooth; Receptors, Neurotransmitter; Recombinant Proteins; Serotonin Antagonists; Substance P | 1992 |
Cholinergic neurons are involved in the effect of substance P on the circular muscle of the guinea pig small intestine.
Topics: Acetylcholine; Animals; Atropine; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurons; Parasympathetic Nervous System; Sincalide; Substance P; Tetrodotoxin | 1992 |
[A new tachykinin receptor revealed by substance P analogues in the guinea pig ileum].
Topics: Animals; Cell Membrane; Duodenum; Guinea Pigs; Ileum; Muscle Contraction; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P | 1992 |
Tachykinin antagonists inhibit nerve-mediated contractions in the circular muscle of the human ileum. Involvement of neurokinin-2 receptors.
Topics: Aged; Aged, 80 and over; Atropine; Electric Stimulation; Humans; Ileum; In Vitro Techniques; Middle Aged; Muscle Contraction; Nervous System Physiological Phenomena; Neurokinin A; Radioimmunoassay; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Tachykinins; Tetrodotoxin | 1992 |
Effect of spinal microinjections of an antagonist to substance P or somatostatin on the exercise pressor reflex.
Topics: Animals; Blood Pressure; Cats; Injections, Spinal; Muscle Contraction; Physical Exertion; Reflex; Sodium Chloride; Somatostatin; Substance P | 1992 |
Postnatal changes in the substance P receptor on rabbit gastric smooth muscle.
Topics: Aging; Animals; Animals, Newborn; Binding, Competitive; Dose-Response Relationship, Drug; Gastric Mucosa; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Osmolar Concentration; Rabbits; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Stomach; Substance P; Tachykinins; Time Factors | 1992 |
Electrical and mechanical effects of acetylcholine and substance P in subregions of canine colon.
Topics: Acetylcholine; Animals; Colon; Dogs; Dose-Response Relationship, Drug; Electrophysiology; Muscle Contraction; Osmolar Concentration; Substance P; Time Factors | 1992 |
Regional differentiation of gastric and of pyloric smooth muscle in the pig: mechanical responses to acetylcholine, histamine, substance P, noradrenaline and adrenaline.
Topics: Acetylcholine; Animals; Electric Stimulation; Epinephrine; Female; Histamine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Norepinephrine; Pylorus; Receptors, Adrenergic; Stomach; Substance P; Swine | 1992 |
Endopeptidase 24.15 modulates bradykinin-induced contraction in guinea-pig trachea.
Topics: Amino Acid Sequence; Animals; Bradykinin; Dose-Response Relationship, Drug; Guinea Pigs; Male; Metalloendopeptidases; Molecular Sequence Data; Muscle Contraction; Oligopeptides; Peptidyl-Dipeptidase A; Substance P; Thiorphan; Trachea | 1992 |
An ubiquitous modulating function of rabbit tracheal epithelium: degradation of tachykinins.
Topics: Animals; Arachidonic Acid; Calcitonin Gene-Related Peptide; Choline; Electric Stimulation; Epithelium; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurokinin A; Protease Inhibitors; Rabbits; Substance P; Tachykinins; Trachea | 1992 |
Viral infection increases contractile but not secretory responses to substance P in ferret trachea.
Topics: Acetylcholine; Animals; Ferrets; Glycopeptides; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neprilysin; Orthomyxoviridae Infections; Substance P; Trachea | 1992 |
Tracheal smooth muscle responses to substance P and neurokinin A in the piglet.
Topics: Animals; Animals, Newborn; Blood Pressure; Muscle Contraction; Muscle Development; Muscle, Smooth; Neprilysin; Neurokinin A; Substance P; Swine; Trachea | 1992 |
Vasoactive intestinal polypeptide induces neurogenic contraction of guinea-pig ileum. Involvement of acetylcholine and substance P.
Topics: Acetylcholine; Animals; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Substance P; Vasoactive Intestinal Peptide | 1992 |
Increased levels of substance P in the myenteric plexus of Trichinella-infected rats.
Topics: Animals; Capsaicin; Carbachol; Male; Muscle Contraction; Myenteric Plexus; Peroxidase; Rats; Rats, Inbred Strains; Substance P; Trichinellosis | 1992 |
Characterization of a vasodilator from the salivary glands of the yellow fever mosquito Aedes aegypti.
Topics: Aedes; Amino Acid Sequence; Animals; Aorta; Chromatography, High Pressure Liquid; Ileum; Molecular Sequence Data; Molecular Weight; Muscle Contraction; Rabbits; Saliva; Salivary Glands; Substance P; Tachykinins; Vasodilation; Vasodilator Agents | 1992 |
Studies on neurokinin antagonists. 1. The design of novel tripeptides possessing the glutaminyl-D-tryptophylphenylalanine sequence as substance P antagonists.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Membrane; Guinea Pigs; Lung; Male; Molecular Sequence Data; Muscle Contraction; Oligopeptides; Peptide Fragments; Structure-Activity Relationship; Substance P; Trachea | 1992 |
Neurokinin receptors and mucosal ion transport in porcine jejunum.
Topics: Animals; Autoradiography; Binding Sites; Biological Transport, Active; Female; Intestinal Mucosa; Jejunum; Male; Muscle Contraction; Neurokinin A; Neurokinin B; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Succinimides; Swine | 1992 |
Intrathecal administration of substance P in the rat: the effect on bladder and urethral sphincteric activity.
Topics: Animals; Electromyography; Injections, Intra-Arterial; Injections, Intravenous; Injections, Spinal; Male; Muscle Contraction; Muscle, Smooth; Pressure; Rats; Rats, Inbred Strains; Substance P; Urethra; Urinary Bladder | 1992 |
Responses of isolated Japanese monkey tracheal muscle to allergic mediators.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Allergens; Animals; Carbachol; Histamine Release; Humans; Immunization, Passive; In Vitro Techniques; Lung; Macaca; Mites; Muscle Contraction; Pollen; Prostaglandin Endoperoxides, Synthetic; SRS-A; Substance P; Trachea | 1992 |
FK 224, a novel cyclopeptide substance P antagonist with NK1 and NK2 receptor selectivity.
Topics: Animals; Binding, Competitive; Biphenyl Compounds; Cell Membrane; Cerebral Cortex; Guinea Pigs; Lung; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptides, Cyclic; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1992 |
The role of cyclic AMP in non-adrenergic non-cholinergic contraction in guinea-pig bronchi.
Topics: Animals; Autonomic Nervous System; Benzopyrans; Bronchi; Bronchodilator Agents; Bucladesine; Colforsin; Cromakalim; Cyclic AMP; Electric Stimulation; Ethanolamines; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurons, Afferent; Nitroprusside; Procaterol; Pyrroles; Substance P; Theophylline | 1992 |
Pharmacological and histological examinations of regional differences of guinea-pig lung: a role of pleural surface smooth muscle in lung strip contraction.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Analgesics; Animals; Calcimycin; Guinea Pigs; Immunoglobulin G; In Vitro Techniques; Lung; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Ovalbumin; Pleura; Prostaglandin Endoperoxides, Synthetic; Substance P | 1992 |
Substance P and calcitonin gene-related peptide in the ureter of chicken and guinea-pig: distribution, binding sites and possible functions.
Topics: Animals; Autoradiography; Binding Sites; Calcitonin Gene-Related Peptide; Chickens; Female; Guinea Pigs; Immunohistochemistry; In Vitro Techniques; Iodine Radioisotopes; Kinins; Male; Muscle Contraction; Muscle, Smooth; Receptors, Calcitonin; Receptors, Cell Surface; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Ureter | 1992 |
In vivo motor effects of loperamide on the rat urinary bladder.
Topics: Acetylcholine; Animals; Drug Interactions; Electric Stimulation; Injections, Intra-Arterial; Loperamide; Male; Muscle Contraction; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Substance P; Urinary Bladder | 1992 |
FR 113680: a novel tripeptide substance P antagonist with NK1 receptor selectivity.
Topics: Animals; Binding, Competitive; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; Lung; Male; Muscle Contraction; Muscle, Smooth; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Synaptic Membranes; Tachykinins; Vas Deferens | 1992 |
Studies on neurokinin antagonists. 2. Design and structure-activity relationships of novel tripeptide substance P antagonists, N alpha-[N alpha-(N alpha-acetyl-L-threonyl)-N1-formyl-D-tryptophyl]-N- methyl-N-(phenylmethyl)-L-phenylalaninamide and its rela
Topics: Acetylcholine; Animals; Blood; Cell Membrane; Guinea Pigs; Histamine; Liver; Lung; Male; Molecular Structure; Muscle Contraction; Oligopeptides; Structure-Activity Relationship; Substance P; Trachea | 1992 |
Excitatory effect of substance P on the antral circular muscle of the guinea-pig stomach.
Topics: Animals; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Stomach; Substance P | 1992 |
WS9326A, a novel tachykinin antagonist isolated from Streptomyces violaceusniger no. 9326. II. Biological and pharmacological properties of WS9326A and tetrahydro-WS9326A (FK224)
Topics: Animals; Dose-Response Relationship, Drug; Edema; Guinea Pigs; In Vitro Techniques; Injections, Intravenous; Lactones; Male; Muscle Contraction; Peptides, Cyclic; Streptomyces; Substance P; Tachykinins; Trachea | 1992 |
Extracellular matrix regulates smooth muscle responses to substance P.
Topics: Amnion; Animals; Basement Membrane; Carbachol; Cells, Cultured; Chick Embryo; Extracellular Matrix; Histamine; In Vitro Techniques; Microscopy, Electron; Muscle Contraction; Muscle, Smooth; Substance P | 1992 |
Effect of resiniferatoxin on the isolated rabbit iris sphincter muscle: comparison with capsaicin and bradykinin.
Topics: Animals; Bradykinin; Capsaicin; Captopril; Diterpenes; Electric Stimulation; Female; Iris; Male; Muscle Contraction; Rabbits; Substance P; Tachykinins; Tachyphylaxis; Thiorphan | 1992 |
Effects of interleukin-1 receptor antagonist on three types of responses to interleukin-1 in rabbit isolated blood vessels.
Topics: Animals; Blood Vessels; Bradykinin; Dose-Response Relationship, Drug; Iloprost; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Mesenteric Arteries; Muscle Contraction; Muscle Relaxation; Norepinephrine; Phenylephrine; Proteins; Rabbits; Receptors, Immunologic; Receptors, Interleukin-1; Recombinant Proteins; Sialoglycoproteins; Substance P; Vasoconstriction; Vasodilation | 1992 |
Effects of the tripeptide substance P antagonist, FR113680, on airway constriction and airway edema induced by neurokinins in guinea-pigs.
Topics: Amino Acid Sequence; Animals; Bronchi; Bronchoconstriction; Capsaicin; Electric Stimulation; Guinea Pigs; Histamine; Kinins; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Oligopeptides; Pulmonary Edema; Substance P; Trachea | 1992 |
Direct contractile effect of motilin on isolated smooth muscle cells of guinea pig small intestine.
Topics: Animals; Atropine; Calcium; Cholecystokinin; Guinea Pigs; In Vitro Techniques; Intestine, Small; Male; Motilin; Muscle Contraction; Muscle, Smooth; Proglumide; Substance P | 1992 |
CP-96,345, a non-peptide antagonist of substance P: I. Effects on the actions mediated by substance P and related tachykinins on the guinea-pig ileum and rabbit jejunum.
Topics: Animals; Biphenyl Compounds; Capsaicin; Electric Stimulation; Guinea Pigs; Hexamethonium Compounds; Histamine; Ileum; In Vitro Techniques; Jejunum; Muscle Contraction; Muscle, Smooth; Parasympathetic Nervous System; Peristalsis; Rabbits; Stereoisomerism; Substance P; Tachykinins | 1992 |
Tachykinin receptors in the guinea-pig renal pelvis: activation by exogenous and endogenous tachykinins.
Topics: Amino Acid Sequence; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Kidney Pelvis; Male; Molecular Sequence Data; Muscle Contraction; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1992 |
Tachykinin receptors in rabbit airways--characterization by functional, autoradiographic and binding studies.
Topics: Amino Acid Sequence; Animals; Autoradiography; Binding Sites; Biphenyl Compounds; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Rabbits; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins; Trachea | 1992 |
Thimerosal blocks stimulated but not basal release of endothelium-derived relaxing factor (EDRF) in dog isolated coronary artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Arginine; Arteries; Bradykinin; Calcimycin; Coronary Vessels; Dogs; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; Nitroprusside; omega-N-Methylarginine; Prostaglandin Endoperoxides, Synthetic; Substance P; Thimerosal; Vasoconstrictor Agents | 1992 |
Maturation of neuromodulatory effect of substance P in rabbit airways.
Topics: Age Factors; Animals; Electric Stimulation; In Vitro Techniques; Muscle Contraction; Neurotransmitter Agents; Rabbits; Substance P; Tetrodotoxin; Trachea | 1990 |
Effects of acetylcholine and substance P on electrical activity of intact toad gastric muscles.
Topics: Acetylcholine; Animals; Bufo marinus; Dose-Response Relationship, Drug; Electrophysiology; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Stomach; Substance P | 1990 |
Does a relationship exist between stress and opioid dependence?
Topics: Adrenal Glands; Animals; Catecholamines; Ileum; In Vitro Techniques; Male; Muscle Contraction; Narcotics; Rats; Rats, Inbred Strains; Stress, Physiological; Substance P; Substance-Related Disorders | 1990 |
Neurokinin receptors mediating substance P-induced contraction in adult rabbit airways.
Topics: Animals; Atropine; Bronchi; Glycopeptides; In Vitro Techniques; Isometric Contraction; Kinetics; Muscle Contraction; Muscle, Smooth; Neostigmine; Neurokinin A; Rabbits; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Trachea | 1990 |
A synthetic glycopeptide of substance P analogue (SP6-11) with enhanced NK-1 receptor specificity.
Topics: Animals; Chromatography, Thin Layer; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Vas Deferens | 1990 |
Somatostatin selectively inhibits excitatory contractile pathways of the feline lower esophageal sphincter.
Topics: Animals; Bethanechol; Bethanechol Compounds; Bombesin; Cats; Electromyography; Esophagogastric Junction; Gastric Fundus; Injections, Intra-Arterial; Male; Manometry; Muscle Contraction; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 1990 |
Muscarinic supersensitivity in the rat urinary bladder after capsaicin pretreatment.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Carbachol; Electric Stimulation; Female; Immunohistochemistry; In Vitro Techniques; Muscle Contraction; Potassium; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Substance P; Urinary Bladder | 1990 |
Phorbol esters inhibit smooth muscle contractions through activation of Na(+)-K(+)-ATPase.
Topics: Animals; Carbachol; Enzyme Activation; Female; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Ouabain; Phorbol Esters; Potassium; Protein Kinase C; Rubidium Radioisotopes; Sodium; Sodium-Potassium-Exchanging ATPase; Substance P | 1990 |
Adenosine receptors are coupled negatively to release of tachykinin(s) from enteric nerve endings.
Topics: Acetylcholine; Animals; Chromatography, High Pressure Liquid; Electric Stimulation; Female; Guinea Pigs; Male; Muscle Contraction; Myenteric Plexus; Nerve Endings; Nucleosides; Receptors, Purinergic; Sincalide; Substance P; Tachykinins; Xanthine; Xanthines | 1990 |
Distribution of substance P receptors in rabbit airways, functional and autoradiographic studies.
Topics: Animals; Autoradiography; Bronchi; Glycopeptides; Muscle Contraction; Rabbits; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Trachea | 1990 |
Suppression by neuropeptide Y of capsaicin-sensitive sensory nerve-mediated contraction in guinea-pig airways.
Topics: Animals; Atropine; Bronchi; Capsaicin; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Neurons, Afferent; Neuropeptide Y; Propranolol; Substance P; Synaptic Transmission; Tetrodotoxin; Trachea | 1990 |
Ileocecal sphincter contraction to colonic distension: a tachykinin-mediated spinal reflex.
Topics: Animals; Atropine; Blood Pressure; Cats; Cecum; Colon; Ileum; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Phenylephrine; Pressure; Reflex; Substance P; Tetrodotoxin; Trimethaphan; Vagotomy; Vasodilator Agents | 1990 |
Detrusor hyperreflexia induced by intravesical instillation of xylene in conscious rats.
Topics: Acetylcholine; Animals; Cystitis; Dinoprostone; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Reflex; Substance P; Urinary Bladder; Xylenes | 1990 |
Human isolated ileum: motor responses of the circular muscle to electrical field stimulation and exogenous neuropeptides.
Topics: Aged; Atropine; Electric Stimulation; Galanin; Humans; Ileum; In Vitro Techniques; Middle Aged; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neuropeptides; omega-Conotoxins; Peptides; Peptides, Cyclic; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Tachykinins; Vasoactive Intestinal Peptide | 1990 |
A possible coupling of postjunctional ATP release and transmitters' receptor stimulation in smooth muscles.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Atropine; Bethanechol; Bethanechol Compounds; Bradykinin; Dinoprost; Guinea Pigs; Histamine; Ileum; Male; Muscle Contraction; Muscle, Smooth; Neurotransmitter Agents; Nifedipine; Norepinephrine; Potassium Chloride; Prazosin; Receptors, Neurotransmitter; Serotonin; Substance P | 1990 |
Spantide II, an effective tachykinin antagonist having high potency and negligible neurotoxicity.
Topics: Amino Acid Sequence; Animals; Colon; Drug Design; Guinea Pigs; Histamine Release; In Vitro Techniques; Indicators and Reagents; Mast Cells; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Nervous System; Rats; Structure-Activity Relationship; Substance P; Tachykinins | 1990 |
HOCl causes airway substance P hyperresponsiveness and neutral endopeptidase hypoactivity.
Topics: Acetylcholine; Animals; Drug Interactions; Glycopeptides; Guinea Pigs; Hydrogen Peroxide; Hypochlorous Acid; In Vitro Techniques; Kinetics; Male; Mucous Membrane; Muscle Contraction; Muscle, Smooth; Neprilysin; Potassium Chloride; Substance P; Trachea | 1990 |
Influence of capsaicin on the reagibility of the isolated guinea pig trachea.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Substance P; Trachea | 1990 |
[The inhibitory effect of disodium cromoglycate on substance P sensory nerve fibres].
Topics: Animals; Asthma; Bronchi; Cromolyn Sodium; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth; Nerve Fibers; Sensory Receptor Cells; Substance P | 1990 |
Effects of substance P on [Ca2+]i and force in intact guinea pig ileal smooth muscle.
Topics: Animals; Calcium; Cytosol; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Potassium; Substance P; Time Factors; Verapamil | 1990 |
Mechanism of endothelin-induced contraction in guinea-pig trachea: comparison with rat aorta.
Topics: Animals; Aorta, Thoracic; Calcium; Carbachol; Endothelins; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Nicardipine; Peptides; Phosphatidylinositols; Potassium; Protein Kinase C; Ryanodine; SRS-A; Substance P; Trachea | 1990 |
An antagonist of neurokinin A, but not substance P, activity on tracheal smooth muscle from guinea-pig.
Topics: Animals; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurokinin A; Substance P; Trachea | 1990 |
Immunoblockade by a specific tachykinin antiserum of the non-cholinergic contractile responses in the guinea-pig isolated bronchus.
Topics: Airway Resistance; Animals; Bronchi; Capsaicin; Electric Stimulation; Eledoisin; Guinea Pigs; Immune Sera; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Substance P | 1990 |
Capsaicin-sensitive and hexamethonium-insensitive circular muscle responses to mesenteric nerve stimulation in the isolated guinea pig ileum.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Female; Gastrointestinal Motility; Guinea Pigs; Hexamethonium; Hexamethonium Compounds; Ileum; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Substance P | 1990 |
Substance P contracts bovine tracheal smooth muscle via activation of myosin light chain kinase.
Topics: Animals; Atropine; Calcium; Cattle; Enzyme Activation; Glycopeptides; In Vitro Techniques; Indomethacin; Ketanserin; Kinetics; Masoprocol; Muscle Contraction; Muscle, Smooth; Myosin Subfragments; Myosin-Light-Chain Kinase; Peptide Mapping; Phosphorylation; Potassium Chloride; Prazosin; Propranolol; Pyrilamine; Substance P; Trachea | 1990 |
Morphine and opioid peptides selectively inhibit the non-cholinergically mediated neurogenic contraction of guinea-pig isolated bronchial muscle.
Topics: Acetylcholine; Animals; Bronchi; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Narcotics; Parasympathetic Nervous System; Substance P | 1990 |
Inhibitors of peptidases: how they influence the biological activities of substance P, neurokinins, kinins and angiotensins in isolated vessels.
Topics: Angiotensin II; Animals; Captopril; Carotid Arteries; Dogs; Female; In Vitro Techniques; Kinins; Leucine; Male; Muscle Contraction; Muscle, Smooth, Vascular; Neurokinin A; Neurokinin B; Portal Vein; Protease Inhibitors; Pulmonary Artery; Rabbits; Rats; Rats, Inbred Strains; Substance P | 1990 |
Inhibitors of peptidases: how they influence the biological activities of substance P, neurokinins, bradykinin and angiotensin in guinea pig, hamster and rat urinary bladders.
Topics: Angiotensin II; Animals; Cricetinae; Female; Guinea Pigs; In Vitro Techniques; Kinins; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Protease Inhibitors; Rats; Rats, Inbred Strains; Substance P; Urinary Bladder | 1990 |
Substance P contracts the human iris sphincter: possible modulation by endogenous enkephalinase.
Topics: Aged; Aged, 80 and over; Carbachol; Female; Humans; Immunoenzyme Techniques; In Vitro Techniques; Iris; Male; Models, Biological; Muscle Contraction; Neprilysin; Substance P; Thiorphan | 1990 |
Effect of capsaicin on the rabbit urinary bladder. What is the function of sensory nerves that contain substance P?
Topics: Animals; Capsaicin; Male; Muscle Contraction; Neurons, Afferent; Rabbits; Substance P; Urinary Bladder | 1990 |
O3-induced mucosa-linked airway muscle hyperresponsiveness in the guinea pig.
Topics: Acetylcholine; Airway Resistance; Animals; Guinea Pigs; In Vitro Techniques; Male; Mucous Membrane; Muscle Contraction; Neprilysin; Ozone; Receptors, Muscarinic; Respiratory Muscles; Substance P; Trachea | 1990 |
Substance P stimulates the opossum sphincter of Oddi in vitro.
Topics: Action Potentials; Ampulla of Vater; Animals; Dose-Response Relationship, Drug; Muscle Contraction; Opossums; Recombinant Proteins; Sphincter of Oddi; Substance P; Tetrodotoxin | 1990 |
The N-terminal 1-16, but not C-terminal 17-29, galanin fragment affects the flexor reflex in rats.
Topics: Animals; Female; Galanin; Morphine; Muscle Contraction; Myelin Sheath; Neurons, Afferent; Peptide Fragments; Peptides; Rats; Rats, Inbred Strains; Reflex; Substance P; Swine | 1990 |
Sensory nerves, vascular endothelium and neurogenic relaxation of the guinea-pig isolated pulmonary artery.
Topics: Animals; Autonomic Nervous System; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Endothelium, Vascular; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Neurons, Afferent; Pulmonary Artery; Receptors, Neurotransmitter; Receptors, Tachykinin; Ruthenium Red; Substance P | 1990 |
A study of the purinoceptors mediating contraction in the rat colon.
Topics: Adenosine; Animals; Colon; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Purines; Rats; Rats, Inbred Strains; Receptors, Purinergic; Substance P; Theophylline | 1990 |
Evidence for the involvement of calcitonin gene-related peptide in the epithelium-dependent contraction of guinea-pig trachea in response to capsaicin.
Topics: Animals; Antibodies; Calcitonin Gene-Related Peptide; Capsaicin; Epithelium; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Substance P; Trachea | 1990 |
The vagal nerves and peptides in the control of extrahepatic biliary motility. An experimental study in the cat.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Atropine; Biliary Tract; Cats; Cholecystokinin; Female; Immunohistochemistry; Male; Movement; Muscle Contraction; Propranolol; Sincalide; Stimulation, Chemical; Substance P; Tetrodotoxin; Vagus Nerve; Vasoactive Intestinal Peptide | 1990 |
Modulation of autonomic neuroeffector transmission by nitric oxide in guinea pig ileum.
Topics: Acetylcholine; Animals; Arginine; Choline; Electric Stimulation; Female; Guinea Pigs; Ileum; In Vitro Techniques; Isomerism; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Nitric Oxide; omega-N-Methylarginine; Substance P; Synaptic Transmission | 1990 |
Occurrence, release, and effects of multiple tachykinins in cat colonic tissues and nerves.
Topics: Animals; Cats; Chromatography, High Pressure Liquid; Colon; Electric Stimulation; Eledoisin; Female; Ganglia, Autonomic; Male; Muscle Contraction; Neurokinin A; Neurokinin B; Physalaemin; Physical Stimulation; Radioimmunoassay; Substance P; Tachykinins; Vasodilation | 1991 |
Airflow obstruction after substance P aerosol: contribution of airway and pulmonary edema.
Topics: Aerosols; Airway Obstruction; Airway Resistance; Animals; Body Weight; Edema; Evans Blue; Guinea Pigs; Lung Compliance; Male; Methacholine Compounds; Microcirculation; Muscle Contraction; Muscle, Smooth; Pulmonary Edema; Respiratory System; Substance P | 1990 |
Differential regulation of smooth muscle contraction in rabbit internal anal sphincter by substance P and bombesin.
Topics: Anal Canal; Animals; Bombesin; Calcium; Dose-Response Relationship, Drug; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Muscle Contraction; Protein Kinase C; Rabbits; Substance P | 1990 |
Spantide II, a novel tachykinin antagonist having high potency and low histamine-releasing effect.
Topics: Amino Acid Sequence; Animals; Guinea Pigs; Histamine Release; In Vitro Techniques; Iris; Male; Mast Cells; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Rabbits; Rats; Rats, Inbred Strains; Substance P | 1990 |
Tachykinins in the canine gastroesophageal junction.
Topics: Animals; Atropine; Chromatography, High Pressure Liquid; Dogs; Dose-Response Relationship, Drug; Esophagogastric Junction; Esophagus; Gastric Mucosa; Immunohistochemistry; Manometry; Muscle Contraction; Neurokinin A; Neurokinin B; Neurons; Phentolamine; Radioimmunoassay; Substance P; Tachykinins; Tetrodotoxin | 1991 |
Sensory-motor neuromodulation of sympathetic vasoconstriction in the rabbit central ear artery.
Topics: Adenosine Diphosphate; Animals; Calcitonin Gene-Related Peptide; Catecholamines; Ear; Electric Stimulation; Fluorescence; Histocytochemistry; In Vitro Techniques; Male; Microscopy, Fluorescence; Motor Neurons; Muscle Contraction; Muscle, Smooth, Vascular; Neurons, Afferent; Rabbits; Regional Blood Flow; Staining and Labeling; Substance P; Sympathetic Nervous System; Synaptic Transmission; Vasoconstriction | 1990 |
Bombesin potentiates the effect of acetylcholine on isolated strips of fish stomach.
Topics: Acetylcholine; Animals; Atropine; Bombesin; Drug Synergism; Fishes; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Stomach; Substance P; Tetrodotoxin; Trout | 1990 |
A potent nonpeptide antagonist of the substance P (NK1) receptor.
Topics: Animals; Binding, Competitive; Biphenyl Compounds; Carotid Arteries; Cattle; Dogs; Molecular Structure; Muscle Contraction; Muscle Relaxation; Rabbits; Rats; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Salivation; Stereoisomerism; Substance P | 1991 |
Development factors in the contractile response of the rabbit bladder to both autonomic and non-autonomic agents.
Topics: Adenosine Triphosphate; Age Factors; Animals; Animals, Newborn; Bethanechol; Bethanechol Compounds; Dose-Response Relationship, Drug; Histamine; Muscle Contraction; Rabbits; Serotonin; Substance P; Urinary Bladder | 1990 |
Effects of piperine on the motility of the isolated guinea-pig ileum: comparison with capsaicin.
Topics: Alkaloids; Animals; Anticonvulsants; Atropine; Benzodioxoles; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nerve Endings; Neurons, Afferent; Piperidines; Polyunsaturated Alkamides; Ruthenium Red; Substance P; Tachyphylaxis; Tetrodotoxin | 1990 |
CCK-8, CCK-4 and gastrin-induced contractions in guinea pig ileum: evidence for differential release of acetylcholine and substance P by CCK-A and CCK-B receptors.
Topics: Acetylcholine; Animals; Benzodiazepinones; Devazepide; Gastrins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Phenylurea Compounds; Receptors, Cholecystokinin; Sincalide; Substance P; Tetragastrin; Tetrodotoxin | 1991 |
Effect of endogenous tachykinins on neuro-effector transmission of vagal nerve in guinea-pig tracheal tissue.
Topics: Acetylcholine; Animals; Atropine; Capsaicin; Electric Stimulation; Female; Glycopeptides; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Neprilysin; Neuroeffector Junction; Physostigmine; Substance P; Synaptic Transmission; Tachykinins; Trachea; Vagus Nerve | 1990 |
Presence of four tachykinins in an acid extract of the carp intestinal bulb (Cyprinus carpio).
Topics: Amino Acid Sequence; Animals; Carps; Chromatography, Gel; Endopeptidases; Guinea Pigs; Hydrogen-Ion Concentration; Ileum; In Vitro Techniques; Intestines; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Species Specificity; Substance P; Tachykinins; Tetrodotoxin | 1990 |
Developmental changes in agonist-mediated colonic smooth muscle contraction in the rabbit.
Topics: Animals; Animals, Newborn; Atropine; Bethanechol; Bethanechol Compounds; Colon; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurokinin A; Potassium; Rabbits; Serotonin; Sincalide; Substance P | 1991 |
Toluene diisocyanate contracts guinea pig bronchial smooth muscle by activating capsaicin-sensitive sensory nerves.
Topics: Animals; Anti-Bacterial Agents; Bronchi; Capsaicin; Glycopeptides; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth; Neurons, Afferent; Substance P; Toluene 2,4-Diisocyanate | 1991 |
Characterization of tachykinin receptors in urinary bladder from guinea pig.
Topics: Animals; Dose-Response Relationship, Drug; Female; Guinea Pigs; Muscle Contraction; Neurokinin A; Neurokinin B; Peptide Fragments; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Urinary Bladder | 1990 |
Characterisation of the neurokinin receptors mediating contraction of isolated tracheal preparations from a variety of species.
Topics: Animals; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Neurokinin B; Peptide Fragments; Rabbits; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Neurotransmitter; Substance P; Swine; Trachea | 1990 |
Tachykinin receptors in the circular muscle of the guinea-pig ileum.
Topics: Animals; Atropine; Carbachol; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tetrodotoxin | 1990 |
Novel selective agonists and antagonists confirm neurokinin NK1 receptors in guinea-pig vas deferens.
Topics: Animals; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Neurokinin A; Neurokinin B; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Tachykinins; Vas Deferens | 1991 |
Release and vascular activity of endothelium-derived relaxing factor in atherosclerotic rabbit aorta.
Topics: Acetylcholine; Animals; Aorta, Abdominal; Aorta, Thoracic; Arteriosclerosis; Calcimycin; Cholesterol, Dietary; Male; Muscle Contraction; Muscle Relaxation; Nitric Oxide; Nitroglycerin; Rabbits; Substance P | 1990 |
Gastrin-releasing peptide is a transmitter mediating porcine gallbladder contraction.
Topics: Animals; Atropine; Carbachol; Electric Stimulation; Gallbladder; Gastrin-Releasing Peptide; Gastrointestinal Hormones; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth; Nerve Fibers; Neurokinin B; Peptides; Sincalide; Substance P; Swine; Tetrodotoxin | 1991 |
Hydrogen peroxide: an endogenous smooth muscle cell hyperpolarizing factor.
Topics: Animals; Coronary Vessels; Deferoxamine; Dinoprost; Endothelium, Vascular; Free Radicals; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; In Vitro Techniques; Mannitol; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Substance P; Swine | 1991 |
Substance P-induced contraction of rabbit airways: mechanism of action.
Topics: Animals; Atropine; Bronchi; Glycopeptides; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Rabbits; Respiratory Muscles; Substance P | 1991 |
Selectivity and specificity of new, non-peptide, quinuclidine antagonists of substance P.
Topics: Angiotensin II; Animals; Blood Vessels; Bradykinin; Cell Line; Guinea Pigs; Humans; Muscle Contraction; Norepinephrine; Quinuclidines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P | 1991 |
In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376.
Topics: Animals; Bronchi; Bronchoconstriction; Cerebral Cortex; Cricetinae; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Mesocricetus; Muscle Contraction; Neurokinin A; Peptide Fragments; Rabbits; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Urinary Bladder; Vagus Nerve | 1991 |
Smooth muscle of rabbit isolated aorta contains the NK-2 tachykinin receptor.
Topics: Animals; Aorta, Thoracic; Female; Kinetics; Male; Muscle Contraction; Muscle, Smooth, Vascular; Neurokinin A; Neurokinin B; Rabbits; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1990 |
Control of locomotion in vitro: II. Chemical stimulation.
Topics: Acetylcholine; Afferent Pathways; Animals; Animals, Newborn; Brain Stem; Culture Techniques; Dopamine; Electromyography; gamma-Aminobutyric Acid; Hindlimb; Locomotion; Medulla Oblongata; Mesencephalon; Motor Activity; Motor Neurons; Muscle Contraction; Muscles; Neurotransmitter Agents; Rats; Reaction Time; Receptors, N-Methyl-D-Aspartate; Serotonin; Spinal Cord; Spinal Nerve Roots; Substance P; Synaptic Transmission | 1991 |
Enkephalinase inhibitor potentiates substance P- and capsaicin-induced bronchial smooth muscle contractions in humans.
Topics: Adult; Aged; Aged, 80 and over; Bronchi; Bronchoconstriction; Capsaicin; Captopril; Drug Synergism; Glycopeptides; Humans; In Vitro Techniques; Middle Aged; Muscle Contraction; Muscle, Smooth; Neprilysin; Substance P | 1991 |
Pharmacological actions of substance P in the rat vas deferens.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Male; Muscle Contraction; Muscle, Smooth; Neurons; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Synapses; Synaptic Transmission; Vas Deferens | 1991 |
Comparison of spantide II and CP-96,345 for blockade of tachykinin-evoked contractions of smooth muscle.
Topics: Analgesics; Animals; Biphenyl Compounds; Female; In Vitro Techniques; Iris; Male; Muscle Contraction; Muscle, Smooth; Rabbits; Substance P; Tachykinins | 1991 |
Mechanism of action of substance P in guinea-pig ileum longitudinal smooth muscle: a re-evaluation.
Topics: Animals; Bradykinin; Carbachol; Cell Membrane Permeability; Eledoisin; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Potassium; Propranolol; Substance P; Tetraethylammonium; Tetraethylammonium Compounds | 1990 |
Comparison of endothelium-dependent responses of monkey cerebral and temporal arteries.
Topics: Acetylcholine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcimycin; Cerebral Arteries; Endothelium, Vascular; Female; Histamine; In Vitro Techniques; Macaca; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Substance P; Temporal Arteries | 1991 |
Acute and chronic effects of intrathecal galanin on behavioural and biochemical markers of spinal motor function in adult rats.
Topics: Analysis of Variance; Animals; Blood Glucose; Brain Stem; Calcitonin Gene-Related Peptide; Choline O-Acetyltransferase; Galanin; Hydroxyindoleacetic Acid; Hypothalamus; Injections, Spinal; Insulin; Male; Methoxydimethyltryptamines; Motor Activity; Muscle Contraction; Peptides; Pyrrolidonecarboxylic Acid; Raphe Nuclei; Rats; Rats, Inbred Strains; Reference Values; Serotonin; Spinal Cord; Stereotyped Behavior; Substance P; Thyrotropin-Releasing Hormone | 1991 |
Synthesis and biological activity of substance P C-terminal hexapeptide and heptapeptide analogues.
Topics: Amino Acid Sequence; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth, Vascular; Peptide Fragments; Portal Vein; Pyrrolidonecarboxylic Acid; Rats; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Vas Deferens | 1991 |
Low level hyperlipidemia impairs endothelium-dependent relaxation of porcine coronary arteries by two mechanisms. Functional change in endothelium and impairment of endothelium-dependent relaxation by two mediators.
Topics: Animals; Bradykinin; Calcimycin; Cholesterol; Coronary Vessels; Endothelium, Vascular; Hyperlipidemias; In Vitro Techniques; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Serotonin; Substance P; Swine | 1991 |
Pseudopeptide analogues of substance P and leucine enkephalinamide containing the psi (CH2O) modification: synthesis and biological activity.
Topics: Amino Acid Sequence; Animals; Enkephalin, Leucine; Guinea Pigs; Ileum; Male; Mice; Molecular Sequence Data; Muscle Contraction; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Substance P; Vas Deferens | 1991 |
Contrasting effects of tachykinins and guanethidine on the acetylcholine output stimulated by nicotine from guinea-pig bladder [corrected].
Topics: Acetylcholine; Analgesics; Animals; Atropine; Female; Guanethidine; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Neurokinin B; Nicotine; Radioimmunoassay; Substance P; Sulfones; Sympathetic Nervous System; Tachykinins; Urinary Bladder | 1991 |
Endothelium-dependent and endothelium-independent vasodilatation of the hepatic artery of the rabbit.
Topics: Animals; Calcitonin Gene-Related Peptide; Endothelium, Vascular; Hepatic Artery; Immunohistochemistry; In Vitro Techniques; Male; Muscle Contraction; Nitroprusside; Norepinephrine; Purines; Rabbits; Substance P; Theophylline; Vasoactive Intestinal Peptide; Vasodilation | 1991 |
Excitatory responses to scyliorhinins I and II in smooth muscle strips isolated from the carp intestinal bulb (Cyprinus carpio).
Topics: Amino Acid Sequence; Animals; Carps; In Vitro Techniques; Intestinal Mucosa; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Substance P; Tachykinins | 1991 |
Tachykinin antagonists and capsaicin-induced contraction of the rat isolated urinary bladder: evidence for tachykinin-mediated cotransmission.
Topics: Adenosine Triphosphate; Animals; Bombesin; Capsaicin; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Rats; Rats, Inbred Strains; Receptors, Purinergic; Substance P; Synaptic Transmission; Tachykinins; Urinary Bladder | 1991 |
Effect of tachykinins in small human airways.
Topics: Bronchi; Bronchoconstriction; Carbachol; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neprilysin; Neurokinin A; Substance P; Thiorphan | 1991 |
Modulation of gastric contractions in response to tachykinins and bethanechol by extrinsic nerves.
Topics: Animals; Bethanechol; Bethanechol Compounds; Dose-Response Relationship, Drug; Female; Male; Muscle Contraction; Neurokinin A; Rats; Rats, Inbred Strains; Reflex; Stomach; Substance P; Tachykinins | 1991 |
Influence of the replacement of amino acid by its D-enantiomer in the sequence of substance P. 1. Binding and pharmacological data.
Topics: Amino Acid Sequence; Animals; Binding Sites; Carotid Arteries; Cerebral Cortex; Dogs; Duodenum; Guinea Pigs; Ileum; Molecular Sequence Data; Muscle Contraction; Rabbits; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Stereoisomerism; Substance P; Synaptosomes; Tachykinins | 1991 |
Drug responses in antigen-induced contractions of tracheal strips of ovalbumin-sensitized guinea pigs.
Topics: Animals; Atropine; Guinea Pigs; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Ovalbumin; Substance P; Trachea | 1990 |
Responses of coronary arteries to neurotransmitters: changes with sexual maturity in the female rabbit.
Topics: Acetylcholine; Aging; Animals; Body Weight; Calcitonin Gene-Related Peptide; Coronary Vessels; Female; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Neuropeptide Y; Neurotransmitter Agents; Norepinephrine; Potassium Chloride; Rabbits; Serotonin; Sexual Maturation; Substance P; Vasoactive Intestinal Peptide | 1991 |
Neurokinin receptors antagonists: old and new.
Topics: Amino Acid Sequence; Analgesics; Animals; Dogs; Guinea Pigs; Kinetics; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth, Vascular; Neurokinin A; Neurokinin B; Peptide Fragments; Rabbits; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1991 |
Carbachol-induced nonspecific desensitization in guinea-pig ileum.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Atropine; Biological Transport, Active; Calcium; Carbachol; Cyclic AMP; Female; Guinea Pigs; Histamine; Ileum; Male; Muscle Contraction; Muscle, Smooth; Ouabain; Potassium; Prostaglandins; Sodium; Substance P; Temperature; Virulence Factors, Bordetella | 1991 |
Pharmacological properties of a potent and selective nonpeptide substance P antagonist.
Topics: Analgesics; Animals; Benzoquinones; Binding, Competitive; Female; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Isoindoles; Kinetics; Male; Mice; Molecular Structure; Morphine; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Muscles; Portal Vein; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Stereoisomerism; Substance P; Urinary Bladder | 1991 |
Pharmacological studies of tachykinin receptors mediating contraction of isolated airway smooth muscle.
Topics: Animals; Cricetinae; Epithelium; Guinea Pigs; In Vitro Techniques; Male; Mesocricetus; Muscle Contraction; Muscle, Smooth; Neurokinin A; Phenoxybenzamine; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins; Trachea | 1991 |
An examination of the proposed functional interaction of substance P and 5-HT in the guinea pig ileum.
Topics: Animals; Capsaicin; Captopril; Glycopeptides; Guinea Pigs; Ileum; Leucine; Muscle Contraction; Muscle, Smooth; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Receptors, Tachykinin; Serotonin; Substance P | 1991 |
Characterization of bradykinin receptors in peripheral organs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Bradykinin; Cricetinae; Guinea Pigs; In Vitro Techniques; Indomethacin; Jugular Veins; Leukotriene Antagonists; Methacholine Compounds; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Neurokinin A; Polyphloretin Phosphate; Prostaglandin Antagonists; Quinolines; Rabbits; Rats; Receptors, Bradykinin; Receptors, Neurotransmitter; Substance P; Trachea; Urinary Bladder | 1991 |
Pharmacological evaluation of the angiotensin, kinin, and neurokinin receptors on the rabbit vena cava.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Bradykinin; Calcium; Calcium Channel Blockers; Calcium Channels; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Potassium Channels; Rabbits; Receptors, Angiotensin; Receptors, Bradykinin; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Sodium Channels; Substance P; Vena Cava, Inferior | 1991 |
Effects of ageing on nicotine-induced contraction and substance P-like materials release in guinea-pig bronchus.
Topics: Aging; Animals; Bronchi; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nicotine; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P | 1991 |
Hsp27 is a mediator of sustained smooth muscle contraction in response to bombesin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Anal Canal; Animals; Antibodies, Monoclonal; Bombesin; Cell Membrane Permeability; Electrophoresis, Gel, Two-Dimensional; Heat-Shock Proteins; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Isoquinolines; Muscle Contraction; Muscle, Smooth; Phosphates; Phosphorus Radioisotopes; Piperazines; Protein Kinase C; Rabbits; Substance P; Sulfonamides | 1991 |
Bombesin receptor antagonists. 2. Analogues based on substance P antagonists.
Topics: 3T3 Cells; Amino Acid Sequence; Amylases; Animals; Grooming; In Vitro Techniques; Male; Mice; Mitogens; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Pancreas; Rats; Receptors, Bombesin; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Urinary Bladder | 1991 |
New reduced peptide bond substance P agonists and antagonists: effects on smooth muscle contraction.
Topics: Amino Acid Sequence; Animals; Guinea Pigs; In Vitro Techniques; Isomerism; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Rats; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1991 |
NK2 tachykinin receptors and contraction of circular muscle of the human colon: characterization of the NK2 receptor subtype.
Topics: Aged; Amino Acid Sequence; Colon; Humans; In Vitro Techniques; Ligands; Middle Aged; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptides; Protease Inhibitors; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins | 1991 |
Mu and kappa opioid receptor modulation of 5-HT3 and NK-3 receptor-evoked release of acetylcholine from the guinea-pig ileum myenteric plexus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics; Animals; Choline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Peptide Fragments; Pyrrolidines; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, Serotonin; Receptors, Tachykinin; Serotonin; Substance P; Tritium | 1991 |
Similarities and differences in the action of resiniferatoxin and capsaicin on central and peripheral endings of primary sensory neurons.
Topics: Anesthesia; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Diterpenes; Ear, External; In Vitro Techniques; Male; Muscle Contraction; Nerve Endings; Neurons, Afferent; Peripheral Nerves; Rabbits; Rats; Rats, Inbred Strains; Reflex; Ruthenium Red; Spinal Cord; Substance P; Urinary Bladder; Urination; Vas Deferens | 1990 |
Species differences in the effects of substance P on inositol trisphosphate accumulation and cyclic AMP formation, and on contraction in isolated iris sphincter of the mammalian eye: differences in receptor density.
Topics: Adenylyl Cyclases; Animals; Cats; Cattle; Cyclic AMP; Dogs; Dose-Response Relationship, Drug; Humans; Inositol 1,4,5-Trisphosphate; Iris; Isoproterenol; Mammals; Muscle Contraction; Muscle, Smooth; Rabbits; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Species Specificity; Substance P; Swine; Type C Phospholipases | 1991 |
Relationship between substance P-induced initial transient contractions and inositol phospholipid hydrolysis in guinea pig ileum.
Topics: Animals; Guinea Pigs; Hydrolysis; Ileum; In Vitro Techniques; Inositol Phosphates; Male; Muscle Contraction; Substance P; Tritium | 1991 |
Evidence for protein kinase C modulation of the ciliary muscle response to carbachol and desensitization.
Topics: Alkaloids; Animals; Carbachol; Cattle; Ciliary Body; Diglycerides; Dinoprost; Enzyme Activation; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Staurosporine; Substance P | 1991 |
Peptides do not induce contractions in gastrointestinal smooth muscle in calcium-free solution.
Topics: Animals; Calcium; Cats; Cholecystokinin; Digestive System; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurotensin; Parasympathomimetics; Peptides; Substance P | 1991 |
Preparation and characterization of monoclonal antibodies to substance P.
Topics: Animals; Antibodies, Monoclonal; Binding Sites; Binding, Competitive; Guinea Pigs; Hybridomas; Ileum; Immunoglobulin G; Immunoglobulin M; Mice; Muscle Contraction; Muscle, Smooth; Protein Binding; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1991 |
Central and local actions of opioids upon reticulo-ruminal motility in sheep.
Topics: Animals; Bradykinin; Enkephalins; Gastrointestinal Motility; In Vitro Techniques; Loperamide; Morphine Derivatives; Muscle Contraction; Naloxone; Narcotics; Prostaglandins E; Reticulum; Rumen; Sheep; Substance P | 1985 |
Capsaicin effects on muscularis mucosa of opossum esophagus: substance P release from afferent nerves?
Topics: Acetylcholine; Animals; Autacoids; Capsaicin; Electric Stimulation; Esophagus; Intercellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Neurons, Afferent; Opossums; Peptides; Substance P; Time Factors | 1985 |
Effect of substance P on opossum duodenal smooth muscle.
Topics: Animals; Duodenum; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Opossums; Substance P; Trifluoperazine | 1985 |
Block of the hyoscine-resistant opiate withdrawal contracture of ileum by a new substance P antagonist [D-Arg1,D-Phe5,D- Trp7,9,Leu 11]substance P.
Topics: Animals; Drug Resistance; Female; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Muscle Contraction; Naloxone; Narcotics; Scopolamine; Substance P; Substance Withdrawal Syndrome | 1985 |
Concentrations and contractile effects of substance P in the human ampullary-isthmic junction.
Topics: Adult; Arteries; Calcium; Fallopian Tubes; Female; Humans; Muscle Contraction; Muscle, Smooth; Nifedipine; Norepinephrine; Potassium; Radioimmunoassay; Substance P; Vasoactive Intestinal Peptide | 1985 |
Activities and antagonism of bombesin on urinary smooth muscles.
Topics: Animals; Atropine; Bombesin; Bradykinin; Guinea Pigs; In Vitro Techniques; Male; Methysergide; Muscle Contraction; Muscle, Smooth; Oligopeptides; Peptides; Propranolol; Rats; Rats, Inbred Strains; Substance P; Urinary Bladder | 1985 |
Anti-substance P anti-idiotypic antibodies. Characterization and biological activities.
Topics: Animals; Antibodies; Antigen-Antibody Complex; Cross Reactions; Fluorescent Antibody Technique; Guinea Pigs; Ileum; Immunoglobulin Idiotypes; Muscle Contraction; Parotid Gland; Phospholipids; Rats; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Structure-Activity Relationship; Substance P | 1985 |
Possible involvement of substance P in the contraction produced by periarterial nerve stimulation in the rat ileum.
Topics: Acetylcholine; Animals; Atropine; Capsaicin; Electric Stimulation; Guanethidine; Ileum; In Vitro Techniques; Indomethacin; Male; Mesentery; Muscle Contraction; Muscle, Smooth; Physostigmine; Rats; Rats, Inbred Strains; Substance P; Synaptic Transmission; Tetraethylammonium Compounds | 1985 |
Effects of bronchoconstrictors and bronchodilators on a novel human small airway preparation.
Topics: Adenosine; Adenosine Triphosphate; Bronchi; Bronchodilator Agents; Carbachol; Histamine; Humans; In Vitro Techniques; Lung; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Prostaglandin D2; Prostaglandins D; Substance P; Terbutaline; Theophylline; Xanthines | 1985 |
A pharmacological study of oesophageal muscularis mucosae from the cat, dog and American opossum (Didelphis virginiana). Addendum.
Topics: Animals; Cats; Dogs; Esophagus; Muscle Contraction; Muscle, Smooth; Opossums; Substance P | 1985 |
The properties of the clonidine withdrawal response of guinea-pig isolated ileum.
Topics: Animals; Atropine; Clonidine; Drug Interactions; Enkephalin, Methionine; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Muscle Contraction; Norepinephrine; Phentolamine; Substance P; Substance Withdrawal Syndrome; Yohimbine | 1985 |
On the nature of the contractile motor responses of the rat stomach elicited by serotonin or substance P in vitro.
Topics: Animals; Atropine; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Ketanserin; Male; Muscle Contraction; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Stomach; Substance P; Tachyphylaxis; Tetrodotoxin | 1985 |
Pharmaco-mechanical coupling in the response to acetylcholine and substance P in the smooth muscle of the rat iris sphincter.
Topics: Acetylcholine; Animals; Barium; Calcium; Capsaicin; Electric Stimulation; Iris; Male; Membrane Potentials; Microelectrodes; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Substance P; Tetrodotoxin | 1985 |
Comparison of the effects of substance P and substance K on blood pressure, salivation and urinary bladder motility in urethane-anaesthetized rats.
Topics: Anesthesia; Animals; Blood Pressure; Dose-Response Relationship, Drug; Male; Muscle Contraction; Nerve Tissue Proteins; Neurokinin A; Rats; Rats, Inbred Strains; Salivation; Substance P; Urethane; Urinary Bladder | 1985 |
Possible involvement of substance P immunoreactive nerves in the mediation of nicotine-induced contractile responses in isolated guinea pig bronchus.
Topics: Animals; Bronchi; Capsaicin; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurons; Nicotine; Substance P | 1985 |
The effects of various pharmacological agents on the metoclopramide-induced increase in cholinergic-mediated contractions of rat isolated forestomach.
Topics: Acetylcholine; Animals; Electric Stimulation; In Vitro Techniques; Male; Metoclopramide; Muscle Contraction; Parasympathetic Nervous System; Rats; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Stomach; Substance P | 1985 |
Tachykinin antagonists: substitutions in positions 5 and 6 with amino acids from the primary sequence of substance P homologues.
Topics: Amino Acid Sequence; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Mesenteric Veins; Muscle Contraction; Muscle, Smooth; Nerve Tissue Proteins; Neuropeptides; Oligopeptides; Rabbits; Rats; Receptors, Neurotransmitter; Receptors, Tachykinin; Structure-Activity Relationship; Substance P; Tachykinins; Trachea; Urinary Bladder | 1985 |
In vivo and in vitro actions of mammalian tachykinins.
Topics: Animals; Blood Pressure; Eledoisin; Female; Guinea Pigs; Hindlimb; Histamine Release; Ileum; In Vitro Techniques; Jejunum; Kassinin; Male; Muscle Contraction; Muscle, Smooth; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Oligopeptides; Rabbits; Rats; Rats, Inbred Strains; Salivation; Substance P; Tachykinins; Vas Deferens; Vasodilation | 1985 |
[Synthesis of cyclic and cyclically branched tachykinin partial sequences. 1. Synthesis of the homodet-cyclic eledoisin(6-11)-hexapeptide].
Topics: Acetylcholine; Animals; Chemical Phenomena; Chemistry; Eledoisin; Female; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Peptide Fragments; Substance P | 1985 |
Effects of some peptides on isolated human penile erectile tissue and cavernous artery.
Topics: Aged; Arginine Vasopressin; Arteries; Electric Stimulation; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Muscle, Smooth, Vascular; Nerve Tissue Proteins; Neuropeptide Y; Norepinephrine; Penis; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 1985 |
Receptors for mammalian tachykinins on isolated intestinal smooth muscle cells.
Topics: Animals; Guinea Pigs; In Vitro Techniques; Intestinal Mucosa; Intestines; Muscle Contraction; Muscle, Smooth; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Oligopeptides; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1985 |
Galanin: neuromodulatory and direct contractile effects on smooth muscle preparations.
Topics: Animals; Colon; Female; Galanin; Guinea Pigs; In Vitro Techniques; Iris; Jejunum; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Neurons; Peptide Fragments; Peptides; Rabbits; Rats; Rats, Inbred Strains; Substance P; Tetrodotoxin; Trachea | 1985 |
Neurokinin B is a preferred agonist for a neuronal substance P receptor and its action is antagonized by enkephalin.
Topics: Animals; Atropine; Enkephalin, Methionine; Guinea Pigs; Ileum; Muscle Contraction; Muscle, Smooth; Naloxone; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Neurons; Neurotransmitter Agents; Oligopeptides; Peptide Fragments; Receptors, Muscarinic; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Substrate Specificity; Tachykinins | 1985 |
Non-nicotinic, non-adrenergic excitatory motor fibres in the preganglionic sympathetic supply to the feline colon. An axon reflex arrangement associated to thin sensory neurons, involving substance P?
Topics: Animals; Axons; Cats; Colon; Electric Stimulation; Female; Gastrointestinal Motility; Hot Temperature; Male; Motor Neurons; Muscle Contraction; Muscle, Smooth; Neurons, Afferent; Physical Stimulation; Reflex; Substance P; Sympathetic Nervous System | 1985 |
Effect of regulatory polypeptides on the substance P stimulated lower esophageal sphincter pressure in pigs.
Topics: Animals; Esophagogastric Junction; In Vitro Techniques; Muscle Contraction; Nerve Tissue Proteins; Peptides; Pressure; Substance P; Swine; Time Factors | 1985 |
Innervation of human omental arteries and veins and vasomotor response to noradrenaline, neuropeptide Y, substance P and vasoactive intestinal peptide.
Topics: Aged; Arteries; Dinoprost; Female; Histocytochemistry; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Muscle, Smooth, Vascular; Nerve Tissue Proteins; Neurons; Neuropeptide Y; Norepinephrine; Omentum; Prazosin; Prostaglandins F; Receptors, Adrenergic, alpha; Regional Blood Flow; Substance P; Vasoactive Intestinal Peptide; Vasomotor System; Veins; Yohimbine | 1985 |
Actions of polypeptides at the neuromuscular junction.
Topics: Action Potentials; Angiotensin II; Animals; Chick Embryo; In Vitro Techniques; Methacholine Compounds; Muscle Contraction; Neuromuscular Junction; Oxytocin; Peptides; Ranidae; Rats; Sciatic Nerve; Substance P; Vasopressins | 1985 |
Desensitization of substance P-induced K+ release in rat parotid.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Oligopeptides; Parasympatholytics; Parotid Gland; Peptide Fragments; Potassium; Pyrrolidonecarboxylic Acid; Rats; Receptors, Adrenergic, alpha; Stimulation, Chemical; Substance P; Time Factors | 1985 |
[Synthesis of cyclic and non-cyclic tachykinin partial sequences. 2. Synthesis of the homocyclic substance P(6-11) hexapeptide].
Topics: Amino Acid Sequence; Animals; Cyclization; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Oligopeptides; Peptide Fragments; Pyrrolidonecarboxylic Acid; Substance P | 1985 |
Substance P: a potent inhibitor of the canine small intestine in vivo.
Topics: Acetylcholine; Animals; Atropine; Benzodiazepinones; Dogs; Dose-Response Relationship, Drug; Enkephalin, Methionine; Female; Gastrointestinal Motility; Hexamethonium Compounds; Intestine, Small; Male; Motilin; Muscle Contraction; Naloxone; Narcotics; Norepinephrine; Pirenzepine; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Receptors, Nicotinic; Receptors, Opioid; Reserpine; Substance P; Tetrodotoxin | 1986 |
Tachykinin receptors in smooth muscles: a study with agonists (substance P, neurokinin A) and antagonists.
Topics: Animals; Cricetinae; Eledoisin; Female; Guinea Pigs; In Vitro Techniques; Kassinin; Male; Muscle Contraction; Muscle, Smooth; Nerve Tissue Proteins; Neurokinin A; Oligopeptides; Physalaemin; Rabbits; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Species Specificity; Substance P | 1985 |
Conformationally constrained tachykinin analogs which are selective ligands for the eledoisin binding site.
Topics: Acetylcholine; Animals; Atropine; Guinea Pigs; Ileum; In Vitro Techniques; Iodine Radioisotopes; Ligands; Muscle Contraction; Nerve Tissue Proteins; Peptide Fragments; Protein Conformation; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Structure-Activity Relationship; Substance P; Tachykinins | 1986 |
The contractile activities of neurokinin A, B and related peptides on smooth muscles.
Topics: Amino Acid Sequence; Animals; Duodenum; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Oligopeptides; Rats; Structure-Activity Relationship; Substance P; Vas Deferens | 1986 |
Apparent enhancement of cholinergic transmission in rabbit bronchi via adenosine A2 receptors.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Bronchi; Electric Stimulation; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Parasympathetic Nervous System; Phenylisopropyladenosine; Rabbits; Receptors, Cell Surface; Receptors, Purinergic; Substance P; Synaptic Transmission; Theophylline; Xanthines | 1986 |
Calcium-dependent stimulation of acetylcholine release by substance P and vasoactive intestinal polypeptide.
Topics: Acetylcholine; Animals; Calcium; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Intestine, Small; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Substance P; Vasoactive Intestinal Peptide; Veratrine | 1986 |
Effect of substance P on neurally mediated contraction of rabbit airway smooth muscle.
Topics: Acetylcholine; Animals; Atropine; Electric Stimulation; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Rabbits; Receptors, Cholinergic; Substance P; Tetrodotoxin; Trachea | 1986 |
Characterization and autoradiographic localization of multiple tachykinin binding sites in gastrointestinal tract and bladder.
Topics: Animals; Autoradiography; Cerebral Cortex; Digestive System; Dose-Response Relationship, Drug; Eledoisin; Guinea Pigs; In Vitro Techniques; Iodine Radioisotopes; Mice; Muscle Contraction; Nerve Tissue Proteins; Neurokinin A; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Succinimides; Tachykinins; Urinary Bladder | 1986 |
[Effect of substance P and VIP on intraocular muscles].
Topics: Animals; Cattle; Dogs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Ocular Physiological Phenomena; Rabbits; Substance P; Vasoactive Intestinal Peptide | 1985 |
Antagonism of non-cholinergic excitatory junction potentials in the guinea-pig ileum by a substance P analogue antagonist.
Topics: Animals; Electric Stimulation; Evoked Potentials; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Neural Inhibition; Substance P | 1986 |
Non-cholinergic inotropic responses evoked by electric field stimulation in the isolated rat urinary bladder. Possible participation of substance P.
Topics: Acetylcholine; Animals; Atropine; Capsaicin; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Rats; Rats, Inbred Strains; Substance P; Tetrodotoxin; Urinary Bladder | 1985 |
Role of substance P nerves in longitudinal smooth muscle contractions of the esophagus.
Topics: Animals; Atropine; Electric Stimulation; Esophagus; Female; Male; Muscle Contraction; Muscle, Smooth; Opossums; Substance P; Time Factors | 1986 |
Contraction of guinea-pig lung parenchymal strips by substance P and related peptides.
Topics: Animals; Bacitracin; Captopril; Chlorpheniramine; Dithiothreitol; Edetic Acid; Eledoisin; Female; Guinea Pigs; Histamine; In Vitro Techniques; Kassinin; Lung; Male; Muscle Contraction; Muscle, Smooth; Oligopeptides; Peptide Fragments; Peptides; Physalaemin; Protease Inhibitors; Substance P | 1985 |
A comparison of the effects of three substance P antagonists on tachykinin-stimulated [3H]-acetylcholine release in the guinea-pig ileum.
Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; Eledoisin; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Nerve Tissue Proteins; Peptide Fragments; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins; Tritium | 1986 |
Effects of calcium channel entry blockers, nifedipine and nilvadipine, on colonic motor activity.
Topics: Acetylcholine; Animals; Blood Pressure; Colon; Dogs; Electric Stimulation; Female; Gastrointestinal Motility; In Vitro Techniques; Male; Muscle Contraction; Nifedipine; Potassium Chloride; Sincalide; Substance P | 1986 |
Determinants of gastroesophageal reflux.
Topics: Bombesin; Diaphragm; Esophagus; Gastroesophageal Reflux; Humans; Muscle Contraction; Muscle, Smooth; Neurotransmitter Agents; Pressure; Substance P | 1985 |
Pyridoxal-5'-phosphate derivatives of substance P: preparation, spasmogenic activity, and degradation by human plasma.
Topics: Animals; Biotransformation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Spectrophotometry, Ultraviolet; Spectrum Analysis; Stimulation, Chemical; Substance P | 1986 |
Central and peripheral motor effects of morphine on the rat urinary bladder.
Topics: Acetylcholine; Animals; Carbidopa; Dose-Response Relationship, Drug; Electric Stimulation; Injections, Intra-Arterial; Injections, Intraventricular; Levodopa; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Pelvis; Rats; Rats, Inbred Strains; Substance P; Urinary Bladder | 1986 |
Multiple neuropeptides exert a direct effect on the same isolated single smooth muscle cell.
Topics: Acetylcholine; Animals; Bombesin; Bufo marinus; Dopamine; Isoproterenol; Muscle Contraction; Muscle, Smooth; Nerve Tissue Proteins; Secretin; Sincalide; Stomach; Substance P; Vasoactive Intestinal Peptide | 1986 |
Immunochemical evidence for substance P-like peptide in tissues of the earthworm Lumbricus terrestris: action on intestinal contraction.
Topics: Acetylcholine; Animals; Immunochemistry; Intestines; Muscle Contraction; Oligochaeta; Radioimmunoassay; Substance P | 1986 |
Evidence that sensory neurons participate in the non-cholinergic, non-adrenergic contractile response of the guinea-pig ileum.
Topics: Animals; Atropine; Capsaicin; Electric Stimulation; Guanethidine; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurons, Afferent; Substance P | 1986 |
Cooling-induced augmentation of the contractile response of the golden hamster tracheal muscle to substance P in-vitro.
Topics: Animals; Caffeine; Calcium; Carbachol; Cold Temperature; Cricetinae; In Vitro Techniques; Male; Mesocricetus; Muscle Contraction; Muscle, Smooth; Potassium Chloride; Substance P; Trachea; Verapamil | 1986 |
Characterization of substance P-induced contractions of guinea-pig trachea.
Topics: Animals; Calcium; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Substance P; Trachea; Vasoactive Intestinal Peptide; Verapamil | 1986 |
Activation of micturition reflex by substance P and substance K: indirect evidence for the existence of multiple tachykinin receptors in the rat urinary bladder.
Topics: Administration, Topical; Animals; Hydroxydopamines; Male; Muscle Contraction; Nerve Tissue Proteins; Neurokinin A; Oxidopamine; Rats; Receptors, Neurotransmitter; Receptors, Tachykinin; Spinal Cord; Substance P; Tetrodotoxin; Urinary Bladder; Urination | 1986 |
Motor effect of neurokinins on the rat duodenum: evidence for the involvement of substance K and substance P receptors.
Topics: Animals; Atropine; Blood Pressure; Dose-Response Relationship, Drug; Drug Synergism; Duodenum; Gastrointestinal Motility; Hexamethonium Compounds; Kassinin; Male; Muscle Contraction; Nerve Tissue Proteins; Neurokinin A; Oligopeptides; Peptide Fragments; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Tetrodotoxin | 1986 |
Characterization of substance P effects on canine antral muscle.
Topics: Animals; Atropine; Calcium; Calcium Channel Blockers; Dogs; Dose-Response Relationship, Drug; Extracellular Space; Female; Hexamethonium; Hexamethonium Compounds; Male; Muscle Contraction; Pyloric Antrum; Substance P; Tetrodotoxin; Time Factors | 1986 |
Immunoneutralization of substance P attenuates the reflex pressor response to muscular contraction.
Topics: Animals; Blood Pressure; Cats; Immune Sera; Injections, Spinal; Muscle Contraction; Reflex; Spinal Cord; Substance P | 1986 |
Specific recognition of SP or NKB receptors by analogues of SP substituted at positions 8 and 9.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurokinin B; Oligopeptides; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P | 1986 |
Characterization of a neurokinin B receptor site in rat brain using a highly selective radioligand.
Topics: Animals; Binding, Competitive; Biological Assay; Cerebral Cortex; Cricetinae; Guanylyl Imidodiphosphate; Guinea Pigs; Ileum; Iodine Radioisotopes; Kinetics; Male; Muscle Contraction; Peptide Fragments; Rats; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Synaptic Membranes; Tissue Distribution; Urinary Bladder; Vas Deferens | 1986 |
Cholinergic neurons mediate intestinal propulsion in the rat.
Topics: Animals; Atropine; Female; Gastrointestinal Motility; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Intestines; Muscle Contraction; Neostigmine; Parasympathetic Nervous System; Rats; Rats, Inbred Strains; Substance P | 1986 |
Effect of substance P on contractions of the gallbladder.
Topics: Animals; Cholecystokinin; Dogs; Dose-Response Relationship, Drug; Drug Evaluation; Gallbladder; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Rabbits; Substance P | 1986 |
Alpha 2-adrenoceptors and endothelium-dependent relaxation in canine large arteries.
Topics: Animals; Dogs; Endothelium; Female; Male; Mathematics; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Prazosin; Propranolol; Prostaglandin Endoperoxides, Synthetic; Receptors, Adrenergic, alpha; Substance P; Vasodilation | 1986 |
Non-cholinergic neurotransmission and the effects of peptides on the urinary bladder of guinea-pigs and rabbits.
Topics: Action Potentials; Animals; Atropine; Chymotrypsin; Electric Stimulation; Enkephalin, Leucine; Guinea Pigs; Muscle Contraction; Neuromuscular Junction; Neurotensin; Peptides; Rabbits; Somatostatin; Substance P; Synaptic Transmission; Urinary Bladder; Vasoactive Intestinal Peptide | 1986 |
Extraction and partial purification of spasmogenic substances in Auerbach's plexus.
Topics: Animals; Biological Assay; Gerbillinae; Guinea Pigs; Ileum; In Vitro Techniques; Methods; Muscle Contraction; Myenteric Plexus; Rabbits; Rats; Spasm; Substance P; Tissue Extracts | 1986 |
Effect of desensitization induced by adenosine 5'-triphosphate, substance P, bradykinin, serotonin, gamma-aminobutyric acid and endogenous noncholinergic-nonadrenergic transmitter in the guinea-pig ileum.
Topics: Adenosine Triphosphate; Animals; Bradykinin; gamma-Aminobutyric Acid; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Male; Muscle Contraction; Neurotransmitter Agents; Serotonin; Substance P; Synaptic Transmission | 1986 |
Effects of substance P on inositol triphosphate accumulation, on contractile responses and on arachidonic acid release and prostaglandin biosynthesis in rabbit iris sphincter muscle.
Topics: Animals; Arachidonic Acids; Diglycerides; Dinoprostone; Dose-Response Relationship, Drug; Female; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Iris; Male; Muscle Contraction; Muscle, Smooth; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phospholipids; Prostaglandins E; Prostaglandins F; Rabbits; Substance P | 1986 |
Studies on effects of the substance P analogues [D-Pro2, D-Trp7,9]-substance P and [D-Arg1, D-Trp7,9, L-Leu11]-substance P not related to their antagonist action.
Topics: Acetylcholine; Animals; Blood Pressure; Guinea Pigs; Histamine Release; In Vitro Techniques; Muscle Contraction; Neuropeptides; Nociceptors; Procaine; Pyrilamine; Rabbits; Regional Blood Flow; Substance P; Tachykinins | 1986 |
Substance P and acetylcholine both suppress the same K+ current in dissociated smooth muscle cells.
Topics: Acetylcholine; Action Potentials; Animals; Bufo marinus; Electric Conductivity; Muscle Contraction; Muscle, Smooth; Physalaemin; Potassium; Receptors, Muscarinic; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P | 1986 |
Effects of neurokinin A, substance P and electrical stimulation on the rabbit iris sphincter muscle.
Topics: Amino Acid Sequence; Animals; Capsaicin; Carbachol; Dose-Response Relationship, Drug; Electric Stimulation; Female; Iris; Male; Muscle Contraction; Neurokinin A; Neuropeptides; Rabbits; Substance P | 1986 |
Tachykinins and calcitonin gene-related peptide in relation to peripheral functions of capsaicin-sensitive sensory neurons.
Topics: Animals; Blood Proteins; Bronchi; Calcitonin Gene-Related Peptide; Capsaicin; Female; Guinea Pigs; Hemodynamics; Histocytochemistry; Humans; Muscle Contraction; Muscle, Smooth; Neurons, Afferent; Neuropeptides; Substance P; Tachykinins; Tissue Distribution; Uterine Contraction | 1986 |
Differentiation of multiple neurokinin receptors in the guinea pig ileum.
Topics: Animals; Atropine; Binding, Competitive; Guinea Pigs; Ileum; Male; Muscle Contraction; Neurokinin A; Neurokinin B; Neuropeptides; Peptide Fragments; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1986 |
Antagonist discrimination between subtypes of tachykinin receptors in the guinea-pig ileum.
Topics: Acetylcholine; Animals; Eledoisin; Female; Guinea Pigs; Ileum; Male; Muscle Contraction; Naloxone; Receptors, Neurotransmitter; Receptors, Tachykinin; Scopolamine; Substance P | 1986 |
A pharmacological and immunohistochemical study of the splanchnic innervation of ileal longitudinal muscle in the toad Bufo marinus.
Topics: Animals; Bufo marinus; Capsaicin; Chymotrypsin; Denervation; Female; Ileum; Immunologic Techniques; Male; Muscle Contraction; Nerve Fibers; Splanchnic Nerves; Substance P | 1986 |
Dual capsaicin effects on ureteric motility: low dose inhibition mediated by calcitonin gene-related peptide and high dose stimulation by tachykinins?
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hemodynamics; Male; Muscle Contraction; Muscle, Smooth; Nerve Tissue Proteins; Neurokinin A; Neuropeptides; Substance P; Tachykinins; Ureter | 1986 |
Highly selective agonists for substance P receptor subtypes.
Topics: Acetylcholine; Animals; Atropine; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Nerve Tissue Proteins; Neuropeptides; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins | 1986 |
Effects of substance-P on mechanical activity of frog muscle fibre.
Topics: Animals; In Vitro Techniques; Muscle Contraction; Muscles; Rana temporaria; Substance P | 1986 |
A tachykinin antagonist inhibits gastric emptying and gastrointestinal transit in the rat.
Topics: Animals; Bombesin; Cimetidine; Female; Gastric Emptying; Gastrointestinal Motility; Guanethidine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neuropeptides; Pyrilamine; Rats; Rats, Inbred Strains; Substance P; Tachykinins | 1986 |
Leukotriene D4 acts in part to contract guinea pig ileum smooth muscle by releasing substance P.
Topics: Animals; Guinea Pigs; Ileum; Muscle Contraction; Muscle, Smooth; Reflex; Secretory Rate; SRS-A; Substance P; Tetrodotoxin; Time Factors | 1987 |
Neural activation of opioid mechanisms in guinea pig ileum by excitatory peptides.
Topics: Acetylcholine; Angiotensin II; Animals; Bombesin; Bradykinin; Cholecystokinin; Corticotropin-Releasing Hormone; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Endorphins; Gastrointestinal Motility; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Naloxone; Neuropeptides; Neurotensin; Receptors, Opioid; Substance P | 1987 |
Antagonists of substance P. Further modifications of substance P antagonists obtained by replacing either positions 7, 9 or 7, 8 and 11 of SP with D-amino acid residues.
Topics: Amino Acid Sequence; Animals; Guinea Pigs; Histamine Release; In Vitro Techniques; Indicators and Reagents; Muscle Contraction; Muscle, Smooth; Structure-Activity Relationship; Substance P | 1986 |
Synthesis and biological activity of substance P C-terminal hexapeptide analogues: structure-activity studies.
Topics: Animals; Guinea Pigs; In Vitro Techniques; Indicators and Reagents; Muscle Contraction; Muscle, Smooth; Oligopeptides; Structure-Activity Relationship; Substance P | 1986 |
[pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype.
Topics: Animals; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurons; Oligopeptides; Parotid Gland; Peptide Fragments; Potassium; Pyrrolidonecarboxylic Acid; Rats; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P | 1986 |
Differentiation between myenteric plexus and longitudinal muscle of the rat jejunum as the site of action of putative enteric neurotransmitters.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Bombesin; Jejunum; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Neurotensin; Neurotransmitter Agents; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin; Sincalide; Substance P; Vasoactive Intestinal Peptide | 1986 |
The mitogenic effects of vasoactive neuropeptides on cultured smooth muscle cell lines.
Topics: Animals; Calcitonin Gene-Related Peptide; Cell Line; Cricetinae; DNA Replication; Kinetics; Male; Mice; Mitogens; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Neuropeptides; Protein Biosynthesis; Rats; Substance P; Vasoactive Intestinal Peptide | 1987 |
Participation of serotonin and substance P in the action of cholecystokinin on colonic motility.
Topics: Animals; Cholecystokinin; Colon; Gastrointestinal Motility; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Serotonin; Substance P | 1987 |
Differential effects of N-formyl-methionyl-leucyl-phenylalanine and substance P on the electrical and contractile properties of airway smooth muscle cells.
Topics: Animals; Electrophysiology; Guinea Pigs; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; N-Formylmethionine Leucyl-Phenylalanine; Osmolar Concentration; Substance P; Trachea | 1987 |
Characterization of tachykinin receptors in isolated basilar arteries of guinea-pig.
Topics: Animals; Basilar Artery; Dinoprost; Endothelium; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Neurokinin A; Neuropeptides; Prostaglandins F; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1987 |
Noncholinergic contractile response to nicotine in the guinea pig isolated tracheal smooth muscle.
Topics: Acetylcholine; Animals; Atropine; Autonomic Nervous System; Capsaicin; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nicotine; Substance P; Trachea | 1987 |
Properties of the feline pyloric sphincter in vitro.
Topics: Action Potentials; Animals; Bethanechol; Bethanechol Compounds; Cats; Duodenum; Electric Stimulation; Hydrochloric Acid; In Vitro Techniques; Muscle Contraction; Pressure; Pylorus; Reflex; Substance P; Tetrodotoxin | 1987 |
Synthesis of (pGlu-5, MePhe-8, Sar-9) substance P (5-11) (DiMe-C7) using a polyacrylamide resin and biological activity on guinea pig ileum and tracheal smooth muscle.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Protein Conformation; Pyrrolidonecarboxylic Acid; Substance P; Trachea | 1987 |
The role of substance P in the human urinary bladder.
Topics: Atropine; Capsaicin; Carbachol; Electric Stimulation; Female; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurotransmitter Agents; Substance P; Urinary Bladder | 1987 |
Neutral endopeptidase-like enzyme controls the contractile activity of substance P in guinea pig lung.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Complement C3; Complement C3a; Complement C5; Complement C5a; Drug Interactions; Endopeptidases; Glycopeptides; Guinea Pigs; Lung; Muscle Contraction; N-Formylmethionine Leucyl-Phenylalanine; Peptidyl-Dipeptidase A; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Thiorphan; Tiopronin; Trachea | 1987 |
Pharmacological evidence for the possible coexistence of multiple receptor sites for mammalian tachykinins in rabbit iris sphincter smooth muscle.
Topics: Animals; Carbachol; Eledoisin; In Vitro Techniques; Iris; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Neuropeptides; Rabbits; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tetrodotoxin | 1987 |
Effect of the tachykinin antagonist, [D-Pro4, D-Trp7,9,10] substance P-(4-11), on tachykinin- and histamine-induced inositol phosphate generation in intestinal smooth muscle.
Topics: Animals; Guinea Pigs; Histamine; In Vitro Techniques; Inositol Phosphates; Intestines; Kassinin; Muscle Contraction; Muscle, Smooth; Neuropeptides; Oligopeptides; Peptide Fragments; Substance P; Sugar Phosphates; Tachykinins | 1987 |
The correlation between sensory-efferent functions mediated by the capsaicin-sensitive neurons and substance P content of the rat urinary bladder.
Topics: Animals; Capsaicin; Denervation; Electric Stimulation; Ganglia, Autonomic; Male; Muscle Contraction; Muscle, Smooth; Neurons, Afferent; Rats; Substance P; Urinary Bladder | 1987 |
Role of substance P in post-tetanic potentiation in myenteric plexus-longitudinal muscle preparations; the effect of substance P-antagonist.
Topics: Animals; Guinea Pigs; Male; Muscle Contraction; Muscles; Myenteric Plexus; Osmolar Concentration; Substance P | 1987 |
Action of the newly discovered mammalian tachykinins, substance K and neuromedin K, on gastroduodenal motility of anesthetized dogs.
Topics: Animals; Dogs; Duodenum; Eledoisin; Gastrointestinal Motility; Muscle Contraction; Neurokinin A; Neurokinin B; Neuropeptides; Physalaemin; Stomach; Substance P; Tachykinins | 1987 |
Development of a large fibromuscular intimal thickening does not impair endothelium-dependent relaxation in the rabbit carotid artery.
Topics: Animals; Calcimycin; Carotid Arteries; Endothelium; Male; Methacholine Chloride; Methacholine Compounds; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Rabbits; Serotonin; Substance P; Vasodilator Agents | 1987 |
The contribution of capsaicin-sensitive innervation to activation of the spinal vesico-vesical reflex in rats: relationship between substance P levels in the urinary bladder and the sensory-efferent function of capsaicin-sensitive sensory neurons.
Topics: Animals; Blood Pressure; Capsaicin; Decerebrate State; Heart Rate; Hexamethonium; Hexamethonium Compounds; Male; Muscle Contraction; Neurons, Afferent; Rats; Rats, Inbred Strains; Reflex; Spinal Cord; Substance P; Time Factors; Urinary Bladder | 1987 |
Role of endothelium in haemoglobin-induced contraction of dog basilar artery.
Topics: Animals; Basilar Artery; Dogs; Endothelium; Female; Hemoglobins; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitroprusside; Octoxynol; Perfusion; Polyethylene Glycols; Substance P | 1987 |
Comparison of the responses to the sensory neuropeptides, substance P, neurokinin A, neurokinin B and calcitonin gene-related peptide and to trigeminal nerve stimulation in the iris sphincter muscle of the rabbit.
Topics: Animals; Atropine; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Eledoisin; Female; Iris; Kinins; Male; Muscle Contraction; Neurokinin A; Neurokinin B; Neuropeptides; Physalaemin; Potassium Chloride; Rabbits; Substance P; Trigeminal Nerve | 1987 |
Involvement of substance P in the excitatory action of GABAA agonists on cholinergic neurons in the guinea-pig ileum.
Topics: Animals; Capsaicin; gamma-Aminobutyric Acid; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscimol; Muscle Contraction; Muscle, Smooth; Parasympathetic Nervous System; Peptide Fragments; Substance P; Taurine | 1987 |
Regional differences in the effects of capsaicin and tachykinins on motor activity and vascular permeability of the rat lower urinary tract.
Topics: Animals; Capillary Permeability; Capsaicin; Electric Stimulation; Evans Blue; Ganglia; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neuropeptides; Rats; Rats, Inbred Strains; Substance P; Urinary Tract | 1987 |
Luminal tachykinin receptors on canine tracheal epithelium: functional subtyping.
Topics: Animals; Dogs; Eledoisin; Epithelial Cells; Epithelium; In Vitro Techniques; Kassinin; Muscle Contraction; Oligopeptides; Physalaemin; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Trachea | 1987 |
Differential effect of ketamine on cholinergic- and noncholinergic-induced contractions of isolated guinea-pig bronchi.
Topics: Animals; Bronchi; Carbachol; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Ketamine; Muscle Contraction; Muscle, Smooth; Parasympathetic Nervous System; Reserpine; Substance P; Sympathetic Nervous System | 1987 |
The presence of mucosa reduces the contractile response of the guinea-pig urinary bladder to substance P.
Topics: Animals; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Mucous Membrane; Muscle Contraction; Muscle, Smooth; Potassium Chloride; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Urinary Bladder | 1987 |
Coexisting peptides in capsaicin-sensitive sensory neurons: release and actions in the respiratory tract of the guinea-pig.
Topics: Animals; Capsaicin; Guinea Pigs; In Vitro Techniques; Lung; Muscle Contraction; Neurokinin A; Neuropeptides; Perfusion; Substance P; Trachea; Vasodilation | 1987 |
Mu-opioid receptors modulate non-cholinergic constrictor nerves in guinea-pig airways.
Topics: Animals; Autonomic Nervous System; Bronchi; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Indicators and Reagents; Male; Morphine; Muscle Contraction; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, mu; Substance P; Trachea | 1987 |
Role of the vagal afferents in substance P-induced respiratory responses in anaesthetized rabbits.
Topics: Afferent Pathways; Animals; Female; Injections, Intra-Arterial; Male; Muscle Contraction; Muscle, Smooth; Phrenic Nerve; Rabbits; Respiration; Substance P; Trachea; Vagotomy; Vagus Nerve | 1987 |
Capsaicin enhances the non-adrenergic twitch response of rat vas deferens.
Topics: Animals; Autonomic Nervous System; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Hydroxydopamines; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neuropeptides; Norepinephrine; Oxidopamine; Peptides; Rats; Rats, Inbred Strains; Reserpine; Substance P; Vas Deferens | 1987 |
Effects of substance P and other neuropeptides on guinea-pig gall-bladder muscle.
Topics: Animals; Electric Stimulation; Gallbladder; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neuropeptides; Substance P | 1987 |
Peptide receptors in the airways.
Topics: Animals; Bradykinin; Carotid Arteries; Dogs; Guinea Pigs; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Neurokinin A; Neurokinin B; Neuropeptides; Portal Vein; Rats; Receptors, Neurotransmitter; Substance P; Trachea | 1987 |
Enkephalinase inhibitor potentiates mammalian tachykinin-induced contraction in ferret trachea.
Topics: Animals; Atropine; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Epithelium; Ferrets; In Vitro Techniques; Metalloendopeptidases; Muscle Contraction; Neprilysin; Neurokinin A; Neurokinin B; Neuropeptides; Substance P; Tachykinins; Thiorphan; Tiopronin; Trachea | 1987 |
Characterization of substance P contractile activity on isolated guinea pig lung tissues.
Topics: Animals; Dose-Response Relationship, Drug; Glycopeptides; Guinea Pigs; In Vitro Techniques; Indomethacin; Lung; Male; Muscle Contraction; Neurokinin A; Neuropeptides; Platelet Activating Factor; Prostaglandins; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Trachea | 1987 |
[Contracting and relaxing action of substance P on the airway muscles in the dog].
Topics: Animals; Bronchi; Dogs; Female; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Substance P; Trachea | 1987 |
Species-related variations in the effects of capsaicin on urinary bladder functions: relation to bladder content of substance P-like immunoreactivity.
Topics: Animals; Capillary Permeability; Capsaicin; Cricetinae; Decerebrate State; Guinea Pigs; In Vitro Techniques; Male; Mice; Muscle Contraction; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Substance P; Urinary Bladder; Urinary Tract; Urination | 1987 |
The efferent role of sensory axons in nerve-evoked contractions of bullfrog bladder.
Topics: Animals; Axons; Dihydro-beta-Erythroidine; Efferent Pathways; Electric Stimulation; Female; Immunohistochemistry; In Vitro Techniques; Male; Muscle Contraction; Neurons, Afferent; Rana catesbeiana; Serotonin; Spinal Nerve Roots; Substance P; Urinary Bladder | 1987 |
Substance P-containing nerves mediate nicotine-induced contractions of rabbit bronchial smooth muscle.
Topics: Acetylcholine; Animals; Atropine; Bronchi; Capsaicin; Histamine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurons; Nicotine; Physostigmine; Rabbits; Substance P | 1988 |
Identification of separate bombesin and substance P receptors on isolated muscle cells from canine gallbladder.
Topics: Animals; Atropine; Bombesin; Dogs; Gallbladder; Muscle Contraction; Muscles; Naloxone; Peptide Fragments; Proglumide; Receptors, Bombesin; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Recombinant Proteins; Software; Substance P | 1988 |
Blockade of sensory nerve mediated contraction of the rabbit iris sphincter by a series of novel tachykinin antagonists.
Topics: Animals; Colon; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Iris; Male; Muscle Contraction; Neuropeptides; Oculomotor Muscles; Rabbits; Substance P; Tachykinins | 1988 |
Tachykinin-induced phosphoinositide breakdown in airway smooth muscle and epithelium: relationship to contraction.
Topics: Animals; Epithelium; Guinea Pigs; In Vitro Techniques; Kinins; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Neuropeptides; Oligopeptides; Phosphatidylinositols; Substance P; Tachykinins; Trachea | 1988 |
[Cyclic analogs of substance P. I. Cyclo(11----epsilon 5)-[Lys5] substance P-(5-11)].
Topics: Animals; Blood Pressure; Chemical Phenomena; Chemistry; Guinea Pigs; In Vitro Techniques; Motor Activity; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Peptides, Cyclic; Rats; Substance P | 1987 |
Endothelium-derived relaxing factor (EDRF) and resistance vessels in an intact vascular bed: a microangiographic study of the rabbit isolated ear.
Topics: Acetylcholine; Angiography; Animals; Biological Products; Drug Resistance; Ear; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Nitric Oxide; Rabbits; Serotonin; Substance P; Vasodilator Agents | 1988 |
Development of non-cholinergic, non-adrenergic excitatory and inhibitory responses to intramural nerve stimulation in rat stomach.
Topics: Animals; Atropine; Carbachol; Electric Stimulation; Gastrointestinal Motility; Muscle Contraction; Muscle Relaxation; Physostigmine; Rats; Rats, Inbred Strains; Stomach; Substance P; Vasoactive Intestinal Peptide | 1988 |
Role of extracellular calcium in the effects of substance P and neurokinin A on guinea pig trachea and human bronchus.
Topics: Animals; Bronchi; Calcium; Guinea Pigs; Humans; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Neurokinin A; Neuropeptides; Nicardipine; Substance P; Theophylline; Trachea; Verapamil | 1988 |
Simultaneous release of substance P- and calcitonin gene-related peptide (CGRP)-like immunoreactivity from isolated muscle of the guinea pig urinary bladder.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; In Vitro Techniques; Male; Muscle Contraction; Muscles; Neurons, Afferent; Neuropeptides; Radioimmunoassay; Substance P; Swine; Tetrodotoxin; Urinary Bladder | 1988 |
Effects of neurotensin on the motility of the isolated gallbladder, bile duct and ampulla in guinea-pigs.
Topics: Animals; Bile Ducts; Female; Gallbladder; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurotensin; Substance P | 1988 |
Several neuropeptides determine the visceromotor response to capsaicin in the guinea-pig isolated ileal longitudinal muscle.
Topics: Animals; Calcitonin; Calcitonin Gene-Related Peptide; Capsaicin; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Neuropeptides; Substance P | 1988 |
Effects of substance P on isolated preparations from rabbit and rat renal arteries.
Topics: Animals; Dinoprost; Electric Stimulation; Indomethacin; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phentolamine; Potassium; Propranolol; Prostaglandins F; Pulmonary Artery; Rabbits; Rats; Rats, Inbred SHR; Renal Artery; Substance P | 1988 |
Contractile response to substance P in isolated smooth muscle strips from the intestinal bulb of the carp (Cyprinus carpio).
Topics: Acetylcholine; Animals; Atropine; Carps; Cyprinidae; Eledoisin; Enkephalin, Methionine; Female; Gastrointestinal Motility; Guinea Pigs; In Vitro Techniques; Intestines; Male; Methysergide; Muscle Contraction; Muscle, Smooth; Physalaemin; Potassium Chloride; Substance P; Tetrodotoxin | 1988 |
Neurokinins induce a relaxation of the rat duodenum "in vivo" by activating postganglionic sympathetic elements in prevertebral ganglia: involvement of an NK-2 type of neurokinin receptor.
Topics: Adrenalectomy; Animals; Duodenum; Guanethidine; Kassinin; Male; Muscle Contraction; Muscle Relaxation; Neurokinin A; Neurokinin B; Neuropeptides; Norepinephrine; Oligopeptides; Phentolamine; Propranolol; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1988 |
Polar innervation of enteric non-cholinergic and non-adrenergic neurons in the isolated guinea-pig ileum.
Topics: Animals; Efferent Pathways; Electric Stimulation; Female; Guanethidine; Guinea Pigs; Hexamethonium; Hexamethonium Compounds; Histamine; Ileum; In Vitro Techniques; Male; Muscle Contraction; Myenteric Plexus; Neurons; Substance P | 1988 |
Receptors for tachykinins in canine intestine circular muscle.
Topics: Animals; Cell Membrane; Dogs; Female; In Vitro Techniques; Intestine, Small; Iodine Radioisotopes; Kinins; Male; Muscle Contraction; Muscle, Smooth; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1988 |
Pressor reflex response to static muscular contraction: its afferent arm and possible neurotransmitters.
Topics: Animals; Antibodies; Blood Pressure; Cats; Dogs; Heart Rate; Hindlimb; Ischemia; Muscle Contraction; Muscles; Neural Conduction; Neurons, Afferent; Neurotransmitter Agents; Physical Stimulation; Reflex; Somatostatin; Substance P | 1988 |
[Quantification of neurokinin A neurokinin B, and substance P in the guinea pig lung by high performance liquid chromatography and subsequent radioimmunoassay].
Topics: Animals; Bronchi; Chromatography, High Pressure Liquid; Guinea Pigs; Lung; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Neuropeptides; Radioimmunoassay; Substance P | 1988 |
Tachykinin-like immunoreactivity in the mammalian urinary bladder: correlation with the functions of the capsaicin-sensitive sensory nerves.
Topics: Animals; Capsaicin; Guinea Pigs; Male; Mice; Muscle Contraction; Neurokinin A; Neurons, Afferent; Neuropeptides; Phenoxybenzamine; Rats; Rats, Inbred Strains; Species Specificity; Substance P; Tachykinins; Urinary Bladder | 1988 |
N-acylated pentapeptides antagonists of substance P on guinea-pig ileum.
Topics: Acylation; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Oligopeptides; Peptide Fragments; Pyrrolidonecarboxylic Acid; Structure-Activity Relationship; Substance P | 1988 |
Biochemical, anatomical and functional correlates of postnatal development of the capsaicin-sensitive innervation of the rat urinary bladder.
Topics: Acetylcholine; Aging; Animals; Capsaicin; Female; Male; Muscle Contraction; Neurons, Afferent; Rats; Rats, Inbred Strains; Substance P; Urinary Bladder | 1988 |
The antagonism induced by ruthenium red of the actions of capsaicin on the peripheral terminals of sensory neurons: further studies.
Topics: Animals; Calcium; Capsaicin; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Neurons, Afferent; Rats; Rats, Inbred Strains; Ruthenium; Ruthenium Red; Substance P; Urinary Bladder | 1988 |
The effect of omega conotoxin GVIA, a peptide modulator of the N-type voltage sensitive calcium channels, on motor responses produced by activation of efferent and sensory nerves in mammalian smooth muscle.
Topics: Animals; Calcium Channel Blockers; Capsaicin; Duodenum; Guinea Pigs; In Vitro Techniques; Male; Mollusk Venoms; Muscle Contraction; Muscle, Smooth; Neuroeffector Junction; Neurons, Afferent; Neurons, Efferent; omega-Conotoxin GVIA; Rats; Rats, Inbred Strains; Substance P; Urinary Bladder; Vas Deferens | 1988 |
Characterization of the effects of neurokinins on canine antral muscle.
Topics: Acetylcholine; Animals; Atropine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dogs; Female; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Pyloric Antrum; Reference Values; Substance P; Tetrodotoxin | 1988 |
Neuropeptide responses and mechanics of the proximal and distal feline colon in vitro.
Topics: Acetylcholine; Animals; Cats; Colon; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurotensin; Organ Specificity; Sincalide; Substance P; Tetrodotoxin | 1988 |
Species differences in the effects of prostaglandins on inositol trisphosphate accumulation, phosphatidic acid formation, myosin light chain phosphorylation and contraction in iris sphincter of the mammalian eye: interaction with the cyclic AMP system.
Topics: Animals; Atropine; Calcium; Carbachol; Cats; Cattle; Cyclic AMP; Dose-Response Relationship, Drug; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Iris; Muscle Contraction; Myosins; Phosphatidic Acids; Phosphorylation; Prazosin; Prostaglandins; Rabbits; Species Specificity; Substance P; Sugar Phosphates; Swine | 1988 |
Action of naloxone on myenteric neurons removed from morphine-treated guinea pigs.
Topics: Acetylcholine; Action Potentials; Animals; Endorphins; Guinea Pigs; Ileum; In Vitro Techniques; Magnesium; Morphine; Muscle Contraction; Myenteric Plexus; Naloxone; Naltrexone; Substance P | 1988 |
Differences in the response of proximal and distal rabbit colonic muscle after electrical field stimulation.
Topics: Animals; Bombesin; Colon; Electric Stimulation; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Muscles; Neurotransmitter Agents; Rabbits; Substance P; Tetrodotoxin | 1989 |
In vivo motor effects of substance P on the rat urinary bladder.
Topics: Animals; Atropine; Electric Stimulation; Hexamethonium; Hexamethonium Compounds; Injections, Intra-Arterial; Male; Motor Neurons; Muscle Contraction; Peptide Fragments; Rats; Rats, Inbred Strains; Substance P; Urinary Bladder | 1988 |
Temperature dependence of the effect of tachykinins on whole guinea-pig ileum in vitro.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth; Neurokinin A; Reference Values; Substance P; Temperature | 1988 |
Involvement of substance P in noncholinergic excitation of rabbit colonic muscle.
Topics: Acetylcholine; Animals; Atropine; Calcium; Colon; Electric Stimulation; Gastrointestinal Motility; Hexamethonium; Hexamethonium Compounds; Male; Muscle Contraction; Neurokinin A; Neurokinin B; Rabbits; Substance P | 1989 |
Neutral endopeptidase inhibitors potentiate substance P-induced contraction in gut smooth muscle.
Topics: Animals; Drug Synergism; Duodenum; Endopeptidases; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Ferrets; Glycopeptides; Ileum; Intestines; Male; Muscle Contraction; Protease Inhibitors; Rats; Substance P; Thiorphan | 1989 |
Influence of epithelium on guinea pig airway responses to tachykinins: role of endopeptidase and cyclooxygenase.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Endopeptidases; Epithelium; Glycopeptides; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Prostaglandin-Endoperoxide Synthases; Substance P; Tachykinins; Trachea | 1989 |
Inhibitors of neutral endopeptidase potentiate electrically and capsaicin-induced noncholinergic contraction in guinea pig bronchi.
Topics: Animals; Bronchi; Capsaicin; Electric Stimulation; Glycopeptides; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Neprilysin; Substance P; Thiorphan | 1989 |
Regional differences in the motor response to capsaicin in the guinea-pig urinary bladder: relative role of pre- and postjunctional factors related to neuropeptide-containing sensory nerves.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cyclic AMP; Guinea Pigs; Histamine; Immune Sera; In Vitro Techniques; Male; Muscle Contraction; Neurons, Afferent; Neuropeptides; Substance P; Tetrodotoxin; Urinary Bladder | 1988 |
Presence of a substance P-like peptide in an acid extract of the intestinal bulb of the carp (Cyprinus carpio).
Topics: Acetylcholine; Adenosine Triphosphate; Angiotensin II; Animals; Carps; Chromatography, Gel; Chymotrypsin; Cyprinidae; Female; Histamine; In Vitro Techniques; Intestines; Male; Muscle Contraction; Muscle, Smooth; Neurotensin; Pepsin A; Serotonin; Substance P; Tissue Extracts | 1988 |
Smooth-muscle effects of substance P.
Topics: Animals; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Substance P; Sympathetic Nervous System; Synaptic Transmission; Vas Deferens | 1988 |
Effect of bombesin and substance P on the smooth muscle of the chicken crop.
Topics: Animals; Bombesin; Chickens; Crop, Avian; Muscle Contraction; Muscle, Smooth; Substance P | 1988 |
Epithelium removal alters responsiveness of guinea pig trachea to substance P.
Topics: Acetylcholine; Animals; Drug Synergism; Epithelium; Glycopeptides; Guinea Pigs; Histological Techniques; In Vitro Techniques; Male; Muscle Contraction; Neprilysin; Substance P; Trachea | 1989 |
Ascending enteric reflex: multiple neurotransmitter systems and interactions.
Topics: Analgesics; Animals; Atropine; Female; Guinea Pigs; Hexamethonium; Hexamethonium Compounds; Ileum; In Vitro Techniques; Jejunum; Male; Muscle Contraction; Muscle, Smooth; Neurotransmitter Agents; Reflex; Substance P; Tetrodotoxin | 1989 |
Release of substance P- and calcitonin gene-related peptide-like immunoreactivity and motor response of the isolated guinea pig gallbladder to capsaicin.
Topics: Animals; Atropine; Calcitonin; Calcitonin Gene-Related Peptide; Capsaicin; Gallbladder; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neuropeptides; Substance P | 1989 |
Release of endothelium-derived relaxing factor is inhibited by 8-bromo-cyclic guanosine monophosphate.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Triphosphate; Animals; Aorta, Thoracic; Biological Factors; Calcimycin; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Nitroprusside; Phenylephrine; Rabbits; Substance P | 1988 |
Smooth-muscle effects of C-terminal tripeptide of substance P.
Topics: Animals; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Peptide Fragments; Rabbits; Rats; Rats, Inbred Strains; Substance P; Vas Deferens | 1988 |
Substance P as a transmitter in the human ciliary muscle.
Topics: Ciliary Body; Electric Stimulation; Humans; Muscle Contraction; Muscles; Neurotransmitter Agents; Oculomotor Muscles; Substance P | 1988 |
[Substance P increases acetylcholine release from vagal nerve terminals].
Topics: Acetylcholine; Animals; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Substance P; Vagus Nerve | 1988 |
Long-term effects of substance P on the isolated guinea pig trachea.
Topics: Animals; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Organ Specificity; Substance P; Trachea | 1988 |
Distribution of substance P in the enteric plexuses of the small intestine of the platypus, Ornithorhynchus anatinus.
Topics: Animals; Electric Stimulation; Immunohistochemistry; In Vitro Techniques; Intestine, Small; Monotremata; Muscle Contraction; Neurons, Afferent; Platypus; Substance P | 1989 |
The diacylglycerol kinase inhibitor, R 59022, suppresses contractility of intestinal smooth muscle.
Topics: Acetylcholine; Animals; Calcium; Diacylglycerol Kinase; Female; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Phosphatidylinositols; Phosphotransferases; Platelet Activating Factor; Pyrimidinones; Substance P; Thiazoles | 1989 |
Enhanced airway responses to substance P after repeated challenge in guinea pigs.
Topics: Animals; Atropine; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Indomethacin; Lung Compliance; Male; Muscle Contraction; Pyrilamine; Respiratory Physiological Phenomena; Respiratory System; Substance P | 1989 |
Increased potency of antagonists of substance P having asparagine in position 6.
Topics: Amino Acid Sequence; Animals; Asparagine; Colon; Drug Combinations; Guinea Pigs; Ileum; In Vitro Techniques; Indicators and Reagents; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Structure-Activity Relationship; Substance P | 1989 |
Effects of substance P, calcitonin gene-related peptide and capsaicin on tension and membrane potential of pig coronary artery in vitro.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Coronary Vessels; In Vitro Techniques; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Neuropeptides; Substance P; Swine | 1989 |
Mechanics and neuropeptide responses of feline pylorus and gastric muscle in vitro.
Topics: Acetylcholine; Animals; Cats; In Vitro Techniques; Muscle Contraction; Neurotensin; Pylorus; Sincalide; Stomach; Substance P; Tetrodotoxin | 1989 |
Contractile effects of substance P and other tachykinins on the mouse isolated distal colon.
Topics: Animals; Calcium; Colon; Eledoisin; In Vitro Techniques; Kassinin; Kinins; Mice; Muscle Contraction; Muscle, Smooth; Nifedipine; Physalaemin; Substance P | 1989 |
Involvement of 5-HT2 receptors in the behaviours produced by intrathecal administration of selected 5-HT agonists and the TRH analogue (CG 3509) to rats.
Topics: 5,7-Dihydroxytryptamine; Animals; Behavior, Animal; Brain Chemistry; DOM 2,5-Dimethoxy-4-Methylamphetamine; Injections, Intraperitoneal; Injections, Spinal; Male; Methoxydimethyltryptamines; Muscle Contraction; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Spinal Cord; Substance P; Thyrotropin-Releasing Hormone | 1989 |
Facilitation by tachykinins of neurotransmission in guinea-pig pulmonary parasympathetic nerves.
Topics: Animals; Eledoisin; Guinea Pigs; In Vitro Techniques; Lung; Muscle Contraction; Neurokinin A; Neurons; Parasympathetic Nervous System; Substance P; Synaptic Transmission; Tachykinins; Trachea | 1989 |
Contractile response of canine gallbladder and sphincter of Oddi to substance P and related peptides in vitro.
Topics: Acetylcholine; Ampulla of Vater; Animals; Atropine; Dogs; Gallbladder; In Vitro Techniques; Male; Muscle Contraction; Peptide Fragments; Physalaemin; Sincalide; Sphincter of Oddi; Structure-Activity Relationship; Substance P | 1989 |
Contractions of the guinea-pig ileum evoked by stimulation of the submucous plexus.
Topics: Animals; Electric Stimulation; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle Denervation; Muscle, Smooth; Submucous Plexus; Substance P | 1989 |
Effect of capsaicin on gastric corpus smooth muscle of the rat in vitro.
Topics: Animals; Autonomic Nervous System; Calcitonin Gene-Related Peptide; Capsaicin; Dimethylphenylpiperazinium Iodide; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neuropeptides; Rats; Rats, Inbred Strains; Stomach; Substance P; Tachyphylaxis; Tetrodotoxin; Vasoactive Intestinal Peptide | 1989 |
Acetylcholine and substance P responsiveness of intestinal smooth muscles in streptozotocin diabetic rats.
Topics: Acetylcholine; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Intestines; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Substance P | 1988 |
The effects of intrathecal galanin and C-fiber stimulation on the flexor reflex in the rat.
Topics: Animals; Calcitonin Gene-Related Peptide; Electric Stimulation; Female; Galanin; Injections, Spinal; Male; Muscle Contraction; Neuropeptides; Peptides; Rats; Rats, Inbred Strains; Reflex; Spinal Cord; Substance P | 1989 |
[The lung and neuropeptides].
Topics: Animals; Humans; Lung; Muscle Contraction; Muscle, Smooth; Neuropeptides; Substance P; Vasoactive Intestinal Peptide | 1989 |
[Synergistic interaction between anti-allergic drugs and beta 2-stimulants on neurogenic contractions of guinea-pig isolated bronchial muscle].
Topics: Acetylcholine; Adrenergic beta-Agonists; Animals; Bronchi; Cromolyn Sodium; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; ortho-Aminobenzoates; Substance P | 1989 |
Neuropeptides in the human appendix. Distribution and motor effects.
Topics: Appendix; Calcitonin Gene-Related Peptide; Enkephalin, Methionine; Enkephalins; Galanin; Gastrin-Releasing Peptide; Humans; Immunohistochemistry; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurons; Neuropeptide Y; Neuropeptides; Peptide PHI; Peptides; Protein Precursors; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 1989 |
Galanin suppresses neurally evoked contractions of circular muscle in the guinea-pig ileum.
Topics: Analgesics; Animals; Electric Stimulation; Galanin; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Peptides; Substance P | 1989 |
The effect of calcium free medium and nifedipine on the release of substance P-like immunoreactivity and contractions induced by capsaicin in the isolated guinea-pig and rat bladder.
Topics: Animals; Calcium; Capsaicin; Edetic Acid; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Potassium; Rats; Rats, Inbred Strains; Substance P; Tetrodotoxin; Urinary Bladder | 1989 |
Relationship between neuropeptides and gastrointestinal smooth muscle activity.
Topics: Animals; Digestive System; Dogs; Enkephalin, Methionine; Muscle Contraction; Muscle, Smooth; Naloxone; Neuropeptides; Substance P | 1989 |
Actions of constrictor (NPY and endothelin) and dilator (substance P, CGRP and VIP) peptides on pig splenic and human skeletal muscle arteries: involvement of the endothelium.
Topics: Aged; Animals; Arteries; Calcitonin Gene-Related Peptide; Endothelins; Endothelium, Vascular; Humans; In Vitro Techniques; Middle Aged; Muscle Contraction; Muscle, Smooth, Vascular; Muscles; Neuropeptide Y; Neuropeptides; Peptides; Regional Blood Flow; Spleen; Substance P; Swine; Vasoactive Intestinal Peptide; Vasoconstrictor Agents; Vasodilator Agents | 1989 |
Extraluminally applied acetylcholine and substance P on the release of EDRF.
Topics: Acetylcholine; Animals; Biological Factors; Dogs; Endothelium, Vascular; Female; Femoral Artery; Infusions, Intra-Arterial; Male; Muscle Contraction; Nitric Oxide; Nitroglycerin; Norepinephrine; Substance P | 1989 |
Effect of thiorphan on response of the guinea-pig gallbladder to tachykinins.
Topics: Animals; Captopril; Gallbladder; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Pyrrolidonecarboxylic Acid; Radioimmunoassay; Substance P; Tachykinins; Thiorphan | 1989 |
Evidence for a myotropic effect of substance P in Periplaneta americana L.
Topics: Animals; Cockroaches; Dose-Response Relationship, Drug; Female; Muscle Contraction; Muscles; Oviducts; Periplaneta; Substance P; Viscera | 1989 |
Synthesis and biological activity of substance P analogues.
Topics: Animals; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Myenteric Plexus; Peptide Fragments; Substance P; Vas Deferens | 1989 |
[Effects of substance P on the contractile response of longitudinal muscle of rat ileum to 5-HT].
Topics: Animals; Female; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Serotonin; Substance P | 1989 |
Characterization of neurokinin effects and receptor selectivity in human isolated bronchi.
Topics: Acetylcholine; Bronchi; Epithelium; Glycopeptides; Humans; In Vitro Techniques; Muscle Contraction; Neurokinin A; Neurokinin B; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Neurotransmitter; Substance P | 1989 |
Classification of tachykinin receptors in muscularis mucosae of opossum oesophagus.
Topics: Animals; Carbachol; Electric Stimulation; Eledoisin; Esophagus; In Vitro Techniques; Mucous Membrane; Muscle Contraction; Muscle, Smooth; Neurokinin A; Opossums; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins | 1989 |
Actions of tachykinins on the rabbit mesenteric artery: substance P and [Glp6,L-Pro9]SP6-11 are potent agonists for endothelial neurokinin-1 receptors.
Topics: Animals; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Tachykinins; Vasodilator Agents | 1989 |
Modulation of non-adrenergic, non-cholinergic neural bronchoconstriction in guinea-pig airways via GABAB-receptors.
Topics: Animals; Atropine; Autonomic Nervous System; Baclofen; Bicuculline; Blood Pressure; Bronchi; Electric Stimulation; gamma-Aminobutyric Acid; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Phentolamine; Propranolol; Receptors, GABA-A; Substance P; Time Factors; Vagus Nerve | 1989 |
Involvement of substance P neurons in contractions of canine small intestine produced by mesenteric nerve stimulation.
Topics: Adrenergic Fibers; Animals; Atropine; Cholinergic Fibers; Dogs; Electric Stimulation; Female; Hexamethonium; Hexamethonium Compounds; Intestine, Small; Male; Muscle Contraction; Muscle, Smooth; Substance P; Sympathectomy; Vagus Nerve | 1989 |
Regional differences in the motor and inflammatory responses to capsaicin in guinea pig airways. Correlation with content and release of substance P-like immunoreactivity.
Topics: Animals; Biomarkers; Blood Proteins; Bronchi; Calcitonin Gene-Related Peptide; Capsaicin; Carbachol; Guinea Pigs; Male; Muscle Contraction; Neurokinin A; Neurons, Afferent; Respiratory Muscles; Substance P; Trachea | 1989 |
The hamster isolated trachea: a new preparation for studying NK-2 receptors.
Topics: Animals; Atropine; Cricetinae; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Pyrilamine; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Tachykinins; Thiorphan; Trachea | 1989 |
[Effect of neurotensin and substance P on the active state of the gastric smooth muscles].
Topics: Animals; Calcium Channels; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Neurotensin; Potassium Channels; Stimulation, Chemical; Stomach; Substance P | 1989 |
Pharmacological characterization of [Leu-13-psi-CH2NH-Leu14]-bombesin as a specific bombesin receptor antagonist on isolated smooth muscle cells.
Topics: Animals; Bombesin; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Receptors, Bombesin; Receptors, Neurotransmitter; Stomach; Substance P | 1989 |
Developmental changes in agonist-mediated gastric smooth muscle contraction in the rabbit.
Topics: Animals; Animals, Newborn; Bethanechol; Bethanechol Compounds; Bombesin; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurotensin; Potassium; Rabbits; Serotonin; Stomach; Substance P | 1989 |
Conformation-activity relationship in hexapeptides related to substance P.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Conformation; Muscle Contraction; Muscle, Smooth; Oligopeptides; Rats; Structure-Activity Relationship; Substance P; Vas Deferens | 1989 |
Regulation of the substance P-induced contraction via the release of acetylcholine and gamma-aminobutyric acid in the guinea-pig urinary bladder.
Topics: Acetylcholine; Animals; Atropine; Bicuculline; Calcium; Female; gamma-Aminobutyric Acid; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Parasympathetic Nervous System; Substance P; Tetrodotoxin; Urinary Bladder | 1989 |
Multiple mechanisms in the motor responses of the guinea-pig isolated urinary bladder to bradykinin.
Topics: Animals; Apamin; Bradykinin; Calcitonin Gene-Related Peptide; Capsaicin; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Endothelium, Vascular; Guinea Pigs; In Vitro Techniques; Indomethacin; Kallidin; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Substance P; Tetrodotoxin; Thiorphan; Urinary Bladder | 1989 |
The autoradiographic distribution of substance P binding sites in guinea-pig vas deferens is altered by capsaicin pretreatment.
Topics: Animals; Autoradiography; Capsaicin; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Vas Deferens | 1989 |
Myenteric 5-HT-containing neurones activate the descending cholinergic excitatory pathway to the circular muscle of guinea-pig ileum.
Topics: Animals; Cocaine; Electric Stimulation; Female; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Male; Muscle Contraction; Myenteric Plexus; Neural Pathways; Neurons; Parasympathetic Nervous System; Serotonin; Substance P; Tetrodotoxin; Tropisetron | 1989 |
Small intestinal transplantation in the rat: effect on physiological properties of smooth muscle and nerves.
Topics: Animals; Gastrointestinal Motility; Intestinal Absorption; Intestine, Small; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Rats; Rats, Inbred Lew; Serotonin; Short Bowel Syndrome; Substance P | 1989 |
A new analogue of substance P with antagonistic properties in renal and pulmonary arteries.
Topics: Animals; Electric Stimulation; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Pulmonary Artery; Rabbits; Rats; Renal Artery; Substance P | 1989 |
Excitatory effect of substance P in parasympathetic ganglia of cat urinary bladder.
Topics: Animals; Atropine; Cats; Enkephalin, Leucine; Evoked Potentials; Female; gamma-Aminobutyric Acid; Ganglia, Parasympathetic; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Substance P; Synaptic Transmission; Urinary Bladder | 1989 |
Further studies on the motor response of the human isolated urinary bladder to tachykinins, capsaicin and electrical field stimulation.
Topics: Adult; Aged; Autonomic Nervous System; Calcitonin Gene-Related Peptide; Capsaicin; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Female; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Pyrrolidonecarboxylic Acid; Substance P; Tachykinins; Thiorphan; Urinary Bladder | 1989 |
Comparison of responses to acetylcholine and serotonin on isolated canine and human coronary arteries.
Topics: Acetylcholine; Adolescent; Adult; Animals; Bradykinin; Child; Coronary Vessels; Dinoprost; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Muscle Contraction; Muscle, Smooth, Vascular; Serotonin; Substance P | 1989 |
[Role of the peptidergic nerves in Hirschsprung's disease and hypoganglionosis].
Topics: Hirschsprung Disease; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurotensin; Neurotransmitter Agents; Substance P; Vasoactive Intestinal Peptide | 1989 |
In vitro activity and selectivity of glucosidic SP(6-11) analogues.
Topics: Animals; Guinea Pigs; Ileum; Male; Muscle Contraction; Peptide Fragments; Substance P; Vas Deferens | 1989 |
Effects of capsaicin on the circular muscle motility of the isolated guinea-pig ileum.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Female; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Substance P | 1989 |
Neurogenically mediated contractions of dog basilar artery involve the release of a thromboxane-like substance.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Basilar Artery; Biphenyl Compounds; Dinoprost; Dogs; Electric Stimulation; Endothelium, Vascular; Female; Heptanoic Acids; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Neurons; Phentolamine; Prostaglandin Endoperoxides, Synthetic; Rabbits; Substance P; Thromboxanes | 1989 |
[Role of tachykinins in non-muscarinic contraction of the isolated guinea-pig colon].
Topics: Analgesics; Animals; Colon; Gastrointestinal Motility; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Substance P; Tachykinins | 1989 |
Substance P elicits thromboxane-induced contraction of canine pulmonary veins.
Topics: Animals; Dogs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Pulmonary Veins; Substance P; Thromboxane A2; Thromboxanes | 1988 |
Dual effects of dynorphin-(1-13) on cholinergic and substance P-ergic transmissions in the rabbit iris sphincter muscle.
Topics: Acetylcholine; Animals; Carbachol; Dynorphins; Electric Stimulation; Endorphins; Female; In Vitro Techniques; Iris; Male; Muscle Contraction; Muscle, Smooth; Narcotics; Peptide Fragments; Rabbits; Receptors, Cholinergic; Substance P; Synaptic Transmission | 1985 |
Effects of neurotensin on the isolated mouse distal colon.
Topics: Acetylcholine; Animals; Apamin; Calcium; Colon; Dose-Response Relationship, Drug; Gastrointestinal Motility; In Vitro Techniques; Ion Channels; Mice; Muscle Contraction; Neurotensin; Potassium; Prostaglandins; Substance P | 1985 |
Evidence for the involvement of endogenous substance P in the motor effects of capsaicin on the rat urinary bladder.
Topics: Acetylcholine; Animals; Capsaicin; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Substance P; Tetrodotoxin; Urinary Bladder | 1985 |
Pupillary supersensitivity to substance P following prolonged treatment with tetrodotoxin or substance P antagonists.
Topics: Animals; Drug Synergism; Electric Stimulation; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neural Conduction; Phenylephrine; Pilocarpine; Pupil; Rabbits; Substance P; Tetrodotoxin | 1985 |
Co-existence of substance P and calcitonin gene-related peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and bronchoconstrictor effects of capsaicin.
Topics: Animals; Bronchi; Calcitonin Gene-Related Peptide; Capsaicin; Guinea Pigs; Heart; In Vitro Techniques; Lung; Male; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Nerve Tissue Proteins; Neurons, Afferent; Substance P | 1985 |
Interaction of tachykinins with an adrenergic receptor in the rat urinary bladder.
Topics: Animals; Autacoids; Eledoisin; Female; In Vitro Techniques; Kassinin; Muscle Contraction; Nerve Tissue Proteins; Neuropeptides; Oligopeptides; Peptide Fragments; Physalaemin; Rats; Receptors, Adrenergic, alpha; Substance P; Tachykinins; Urinary Bladder | 1985 |
Substance P enteric neurons mediate non-cholinergic transmission to the circular muscle of the guinea-pig intestine.
Topics: Animals; Female; Guinea Pigs; In Vitro Techniques; Intestine, Small; Male; Muscle Contraction; Neurons; Reflex; Scopolamine; Substance P; Synaptic Transmission; Tetrodotoxin | 1985 |
Effects of substance P antagonists on the atropine-sensitive and atropine-resistant responses of guinea-pig ileum to substance P.
Topics: Acetylcholine; Animals; Atropine; Cholinergic Fibers; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; Intercellular Signaling Peptides and Proteins; Muscle Contraction; Peptides; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P | 1985 |
The effect of substance P on the mechanical and electrical responses of frog, chick and rat skeletal muscle.
Topics: Acetylcholine; Action Potentials; Animals; Anura; Chickens; Electric Stimulation; In Vitro Techniques; Muscle Contraction; Muscles; Neuromuscular Junction; Rats; Sciatic Nerve; Species Specificity; Substance P; Tetraethylammonium Compounds | 1985 |
Neuropeptide K: isolation, structure and biological activities of a novel brain tachykinin.
Topics: Amino Acid Sequence; Animals; Blood Pressure; Brain Chemistry; Chromatography, High Pressure Liquid; Gallbladder; Guinea Pigs; Kassinin; Muscle Contraction; Nerve Tissue Proteins; Neurokinin A; Oligopeptides; Substance P; Swine; Tachykinins | 1985 |
Attenuation of the reflex pressor response to muscular contraction by a substance P antagonist.
Topics: Animals; Blood Pressure; Cats; Injections, Spinal; Muscle Contraction; Physical Exertion; Reflex; Substance P | 1985 |
Some characterization of the responses to substance P and other tachykinins in rabbit iris sphincter muscle.
Topics: Animals; Atropine; Carbachol; Eledoisin; In Vitro Techniques; Iris; Kinins; Muscle Contraction; Muscle, Smooth; Phenoxybenzamine; Physalaemin; Rabbits; Substance P; Tetrodotoxin | 1985 |
Study of the contractile effect of 5-hydroxytryptamine (5-HT) in the isolated longitudinal muscle strip from guinea-pig ileum. Evidence for two distinct release mechanisms.
Topics: Animals; Atropine; Capsaicin; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Male; Methysergide; Morphine; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Physostigmine; Serotonin; Serotonin Antagonists; Substance P; Tetrodotoxin; Tropisetron | 1985 |
Substance P action on phosphoinositides in guinea-pig intestinal muscle: a possible transduction mechanism?
Topics: Animals; Female; Guinea Pigs; In Vitro Techniques; Intestine, Small; Lithium; Male; Muscle Contraction; Osmolar Concentration; Phosphatidylinositols; Solubility; Substance P; Time Factors; Water | 1985 |
Seasonal variations in the nature of neurotransmitters in a frog vagus-stomach muscle preparation.
Topics: Acetylcholine; Animals; Anura; Atropine; Biphenyl Compounds; Ganglionic Blockers; Histamine; Histamine H1 Antagonists; In Vitro Techniques; Lysergic Acid Diethylamide; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Peptides; Physostigmine; Seasons; Serotonin; Stomach; Substance P; Tryptamines; Vagus Nerve | 1964 |
Release of a bradykinin-like substance of nervous stimulation of a frog stomach muscle preparation.
Topics: Animals; Anura; Aspirin; Bradykinin; Intestine, Small; Muscle Contraction; Muscle, Smooth; Peptides; Rabbits; Stomach; Substance P; Vagus Nerve | 1967 |
Quantitative study of P substance in the megaesophagus and megacolon of human Trypanosoma cruzi infections.
Topics: Adult; Aged; Animals; Biological Assay; Bradykinin; Chagas Disease; Child, Preschool; Colon; Duodenum; Esophageal Achalasia; Esophagus; Female; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Megacolon; Middle Aged; Muscle Contraction; Rats; Substance P; Trypanosoma cruzi | 1973 |
Comparison of crude bovine subcortical substance P with synthetic substance P.
Topics: Animals; Brain Chemistry; Cattle; Cerebral Cortex; Chemical Phenomena; Chemistry; Chickens; Chromatography, Thin Layer; Electrophoresis, Paper; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Peptides; Rats; Substance P; Uterus | 1973 |
Interaction of prostaglandins and indomethacin with algesic substances.
Topics: Acetylcholine; Analgesics; Animals; Blood Pressure; Bradykinin; Drug Interactions; Ear; Guinea Pigs; Ileum; In Vitro Techniques; Indomethacin; Muscle Contraction; Perfusion; Prostaglandins; Rabbits; Regional Blood Flow; Serotonin; Serotonin Antagonists; Substance P | 1974 |
The relation between ionic fluxes and the action of drugs on smooth muscle.
Topics: Angiotensin II; Animals; Anura; Bradykinin; Calcium; Histamine; In Vitro Techniques; Kallidin; Muscle Contraction; Muscle, Smooth; Peptides; Stomach; Substance P | 1964 |
Potentiation by smooth muscle stimulants of the hypogastric nerve--vas deferens preparation from normal and castrated guinea-pigs.
Topics: Acetylcholine; Amines; Angiotensin II; Animals; Atropine; Barium; Bradykinin; Castration; Electric Stimulation; Epinephrine; Guinea Pigs; Histamine; Hypogastric Plexus; Lysergic Acid Diethylamide; Male; Muscle Contraction; Norepinephrine; Oxytocin; Phenethylamines; Phentolamine; Prostaglandins; Serotonin; Substance P; Vas Deferens; Vasopressins | 1968 |
The action of polypeptides, amines and prostaglandins on isolated smooth muscle preparations of seminal vesicles and deferent ducts.
Topics: Acetylcholine; Amines; Angiotensin II; Animals; Anura; Bradykinin; Ceruletide; Cricetinae; Eledoisin; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Oxytocin; Peptides; Prostaglandins; Rats; Seminal Vesicles; Serotonin; Substance P; Vas Deferens; Vasopressins | 1973 |
[Receptors of the mammalian intestine].
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Intestine, Small; Muscle Contraction; Muscle, Smooth; Receptors, Drug; Substance P; Sympatholytics | 1969 |
[Differentiation of the biological activity of eledoisin and substance-P analogs in affinity and intrinsic activity on isolated guinea pig ileum and comparison with the activity on rat colon].
Topics: Animals; Binding Sites; Colon; Dose-Response Relationship, Drug; Eledoisin; Guinea Pigs; Ileum; Muscle Contraction; Muscle, Smooth; Rats; Receptors, Drug; Structure-Activity Relationship; Substance P | 1974 |
Phenoxybenzamine blockade of the enhancing effect of substance P on the twitch induced by transmural nerve stimulation in the guinea pig vas deferens.
Topics: Acetylcholine; Animals; Depression, Chemical; Drug Interactions; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Phenoxybenzamine; Potassium Chloride; Stimulation, Chemical; Substance P; Time Factors; Vas Deferens | 1974 |
Synthesis and some biological activities of substance P.
Topics: Animals; Blood Pressure; Dogs; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Guinea Pigs; Ileum; In Vitro Techniques; Luteinizing Hormone; Methods; Muscle Contraction; Muscles; Pituitary Gland; Rats; Regional Blood Flow; Substance P | 1974 |
[Influence of chain length of the C-terminal sequences of substance P-compared with analogous physalaemin- and eledoisin- peptides-on the effect on guines pig ileum].
Topics: Amino Acid Sequence; Animals; Eledoisin; Ileum; Muscle Contraction; Peptides; Structure-Activity Relationship; Substance P | 1974 |
Isolation of a sialogogic peptide from bovine hypothalamic tissue and its characterization as substance P.
Topics: Amino Acids; Animals; Arginine; Chromatography, Gel; Chromatography, Ion Exchange; Duodenum; Electrophoresis; Guinea Pigs; Hydrogen-Ion Concentration; Hypothalamus; Ileum; Muscle Contraction; Muscle, Smooth; Peptides; Rats; Salivation; Substance P; Vasoconstrictor Agents | 1970 |
Influence of morphine, methadone and methadone isomers on some effects of smooth muscle stimulants.
Topics: Acetylcholine; Animals; Barium; Bradykinin; Capillary Permeability; Depression, Chemical; Female; Guinea Pigs; Ileum; Isomerism; Methadone; Morphine; Muscle Contraction; Muscle, Smooth; Rats; Serotonin Antagonists; Stereoisomerism; Structure-Activity Relationship; Substance P; Uterus | 1970 |
An unidentified smooth-muscle-stimulating factor in egg white.
Topics: Animals; Egg White; Female; Guinea Pigs; Intestines; Muscle Contraction; Muscle, Smooth; Peptides; Rats; Substance P; Uterus | 1970 |
A modification of the technique of the Gaddum and Stephenson microbath.
Topics: Acetylcholine; Microchemistry; Muscle Contraction; Peptides; Substance P | 1965 |