substance p has been researched along with Inflammation in 487 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 53 (10.88) | 18.7374 |
| 1990's | 144 (29.57) | 18.2507 |
| 2000's | 137 (28.13) | 29.6817 |
| 2010's | 120 (24.64) | 24.3611 |
| 2020's | 33 (6.78) | 2.80 |
| Authors | Studies |
|---|---|
| Dong, X; Han, L; Kulka, M; McNeil, BD; Meeker, S; Pundir, P; Undem, BJ | 1 |
| Gong, M; Li, Q; Liu, Y; Lu, M; Xia, Y; Xu, B; Xu, T; Yu, Z | 1 |
| Bhatia, M; Kumar, A | 1 |
| Esteban, F; González-Moles, MÁ; Muñoz, M; Ramos-García, P | 1 |
| Okayama, Y; Toyoshima, S | 1 |
| Li, M; Xu, WT; Zhong, X | 1 |
| Johnson, MB; Marriott, I; Sipprell, SE; Suptela, SR | 1 |
| Arifuzzaman, M; Artis, D; Bessman, NJ; Chu, C; Guo, CJ; Hu, H; Jin, WB; Li, TT; Lyu, M; Parkhurst, CN; Putzel, GG; Tsou, AM; Xie, Z; Yano, H; Zhang, W; Zhou, J; Zhou, L | 1 |
| Argunhan, F; Brain, SD; Chaudhry, H; de Sousa Valente, J; Ghanim, H; Zarban, AA | 1 |
| Chen, H; Ge, W; Huang, Y; Jiang, J; Jin, Z; Kong, Y; Li, F; Li, L; Li, M; Liu, X; Zeng, X; Zhanmu, O | 1 |
| Di Primo, C; Dilly, S; Goupil-Lamy, A; Henri, J; Minder, L; Mohanasundaram, K; Slama Schwok, A | 1 |
| Ayaz, Y; Erin, N; İlhan, HD; Ünal, B | 1 |
| Caraffa, A; Carinci, F; Conti, P; D'Ovidio, C; Frydas, I; Gallenga, CE; Kritas, SK; Lauritano, D; Mastrangelo, F; Ronconi, G; Trimarchi, M | 1 |
| Chen, FX; Fang, J; Hu, J; Li, QL; Peng, L; Wan, Q | 1 |
| Guan, H; Jiang, X; Lan, HY; Li, J; Li, N; Liu, Y; Shu, X; Xia, Y; Zheng, Z; Zhong, M; Zhu, E | 1 |
| Bhatia, M; Zhu, Z | 1 |
| Hong, HS; Hwang, DY; Kim, D; Lee, D; Park, JS; Piao, J | 1 |
| Cao, Y; Chen, Q; Fu, C; Ge, C; Huang, F; Huang, H; Kang, J; Liu, L; Pearson, RB; Shi, Y; Sun, Y; Wang, X; Wu, H; Yang, T; Zhang, T; Zhou, H | 1 |
| Huang, C; Liao, D; Lin, J; Liu, F; Liu, M; Shen, J; Song, N; Wang, H; Zhang, Y; Zhou, C | 1 |
| Gunes, H; Kilinc, E | 1 |
| Liu, S; Maeyama, K; Mogi, M; Sahid, MNA | 1 |
| Dana, R; Liu, L; Yin, J | 1 |
| Di, T; Fu, J; Guo, J; Li, N; Li, P; Meng, Y; Wang, Y; Zhang, L; Zhao, J | 1 |
| Burcher, E; Dai, L; Liu, L; Perera, DS | 1 |
| Altdorfer, K; Fehér, E | 1 |
| Bubak, AN; Como, CN; Das, A; Doyle-Meyers, L; Feia, B; Looper, J; Mahalingam, R; Nagel, MA; Pearce, CM; Traina-Dorge, V | 1 |
| Jin, LY; Li, XF; Luo, Y; Song, XX; Yu, BW | 1 |
| Hong, HS; Jin, Y; Kim, S; Son, Y | 1 |
| Fukushige, R; Hisaoka-Nakashima, K; Kishida, Y; Morioka, N; Nakamura, Y; Nakata, Y; Watanabe, K | 1 |
| Barragan, AA; Bas, S; Bauman, LM; Coetzee, JF; Gonzalez, JDR; Lakritz, J; Menichetti, B; Piñeiro, JM; Schuenemann, GM; Velez, J | 1 |
| Camargo, LL; Cerqueira, ARA; Costa, SKP; Denadai-Souza, A; Fernandes, ES; Ferro, ES; Gewehr, MCF; Lima, C; Muscará, MN; Schenka, AA; Teixeira, SA; Yshii, LM | 1 |
| Hong, HS; Hwang, DY; Park, JS; Piao, J; Son, Y | 1 |
| Burckhardt, BB; Feickert, M | 1 |
| Hong, HS; Kim, S | 1 |
| Gilani, SA; Hanif, A; Hassan, A; Hassan, S; Mehboob, R; Tanvir, I; Waseem, H | 1 |
| Asti, M; Bettini, G; Chiocchetti, R; Fracassi, F; Giancola, F; Pietra, M; Polidoro, G | 1 |
| Hellman, J; Lawton, SK; Prakash, A; Schumacher, M; Tran, A; Wilhelmsen, K; Wong, E; Xu, F | 1 |
| Suvas, S | 1 |
| Ali, H | 1 |
| Burmeister, AR; Chauhan, VS; Cooley, ID; Johnson, MB; Marriott, I; Martinez, AN; Moerdyk-Schauwecker, MJ; Philipp, MT; Ramesh, G; Young, AD | 1 |
| Fang, K; Huang, V; Iliopoulos, D; Kevil, CG; Law, IKM; Padua, D; Pothoulakis, C; Sideri, A | 1 |
| Barbosa-Cobos, RE; Becerril-Mendoza, LT; Flores-Estrada, J; Lugo-Zamudio, G; Moreno, J; Moreno-Eutimio, MA; Ramirez-Bello, J; Rodríguez-Henríquez, P; Torres-González, R | 1 |
| Gellatly, D; Janzen, ED; Marti, S; Meléndez, DM; Moya, D; Pajor, EA; Schwartzkopf-Genswein, KS | 1 |
| Barry, CM; Haberberger, RV; Ji, E; Kyloh, M; Sharma, H; Spencer, NJ; Vilimas, P; Yap, P | 1 |
| Hong, HS; Piao, J; Son, Y | 1 |
| Antonioli, L; Benvenuti, L; Bernardini, N; Blandizzi, C; Carpi, S; Colucci, R; Duranti, E; Fornai, M; Gentile, D; Ippolito, C; Németh, ZH; Nieri, P; Pellegrini, C; Pistelli, L; Segnani, C; Tirotta, E; Virdis, A | 1 |
| Kang, H; Li, X; Liu, D; Liu, Z; Wu, J; Yang, S; Zeng, B; Zhang, Q; Zhong, Z | 1 |
| Baudoin, T; Geber, G; Kalogjera, L; Megla, ZB; Scadding, G; Tomljenovic, D | 1 |
| Almejún, MB; Colado, A; Fuentes, F; Galletti, JG; Giordano, MN; Guzmán, M; Keitelman, IA; Miglio, MS; Sabbione, F; Trevani, AS; Zgajnar, NR | 1 |
| Duffy, ER; Mella, JR; Remick, DG; Stucchi, AF | 1 |
| Augustyniak, D; Drulis-Kawa, Z; Gorczyca, D; Roszkowiak, J; Skała, J; Wiśniewska, I | 1 |
| Arkless, KL; Aubdool, AA; Brain, SD; Caton, P; Cleary, SJ; Evans, E; Kee, Z; Kodji, X; Pitchford, SC | 1 |
| Capizzi, A; Ghezzi, M; Rossi, GA; Sacco, O; Silvestri, M | 1 |
| Bastian, A; Cioplea, M; Micu, G; Nichita, L; Popp, C; Stăniceanu, F; Sticlaru, L | 1 |
| Doche, I; Ericson, M; Hordinsky, MK; McAdams, BD; Romiti, R; Valente, NS; Wilcox, GL | 1 |
| El-Nour, H; Holst, M; Johansson, B; Lönndahl, L; Lonne-Rahm, SB; Nordlind, K; Radu Djurfeldt, D; Rasul, A | 1 |
| Cheng, XW; Hong, HS; Kim, S; Kim, W; Lee, KH; Lee, S; Son, Y; Woo, JS | 1 |
| Hong, HS; Hwang, DY; Kim, S; Park, JS; Piao, J; Son, Y | 1 |
| Agogo, GO; Guo, J; Peng, L; Yan, M | 1 |
| Asano, T; Fukumitsu, K; Hijikata, H; Kamiya, T; Kanemitsu, Y; Kubota, E; Niimi, A; Suzuki, M; Takeda, N; Takemura, M; Ueda, T; Yamaba, Y | 1 |
| Best, TM; Bowles, AC; Colombini, A; Correa, D; Kaplan, LD; Kouroupis, D; Perucca Orfei, C; Willman, MA | 1 |
| Berger, A; Borbély, E; Hajna, Z; Helyes, Z; Kereskai, L; Nagy, P; Paige, C; Pintér, E; Quinn, J; Sándor, K; Stewart, J; Szolcsányi, J; Tóth, I; Zimmer, A | 1 |
| Ma, W; Quirion, R; Shukla, M | 1 |
| Chun, J; Khan, S; Kim, YS; Shehzad, O | 1 |
| Ahn, W; Chi, GF; Chung, E; Jiang, MH; Lim, JE; Son, Y; Zhang, M | 1 |
| Barbeiro, HV; da Cruz Neto, LM; da Silva, FP; de Souza, HP; Goulart, AC; Machado, MC; Sallet, PC; Torggler Filho, F; Velasco, IT; Zampieri, FG | 1 |
| Ansai, T; Awano, S; Kinoshita, N; Nakata, M; Yoshida, A | 1 |
| Chen, W; Corder, GF; Fu, W; Kuphal, KE; Marvizon, JC; McCarson, KE; Stiller, CO; Taylor, BK; Urban, JH; Winter, MK | 1 |
| Andersen, HH; Kullander, K; Lagerström, MC; Rogoz, K | 1 |
| Alhelal, MA; Letourneau, R; Palaska, I; Panagiotidou, S; Theoharides, TC | 1 |
| Chen, W; Marvizón, JC; McRoberts, JA | 1 |
| Hamity, MV; Hammond, DL; Walder, RY | 1 |
| Bhatia, M; Sun, J | 1 |
| Coveñas, R; Muñoz, M | 1 |
| Altier, C; Benson, JR; Lapointe, TK; Lomax, AE; Moynes, DM; Vanner, SJ; Xu, J | 1 |
| Anta, B; Arévalo, JC; Calvo, L; López-Bellido, R; López-Benito, S; Rodriguez, RE; Tessarollo, L; Vicente-García, C; Yu, T | 1 |
| Ackermann, PW; Bring, D; Stålman, A | 1 |
| Leonard, AV; Thornton, E; Vink, R | 1 |
| Mohan, MP; Satheeshkumar, PS | 1 |
| Condjella, RM; Conley, O; Dahl, MV; Fryer, AD; Jacoby, DB; Jacoby, NW; Kloeber, JA; Lee, JJ; Lee, NA; Luo, H; Maizer, P; Mazzolini, A; Neely, JL; Ochkur, SI; Patel, YS; Protheroe, CA; Raish, RJ; Scott, GD; Vega, ML; Zellner, KR | 1 |
| Balla, K; Bendele, A; Bogseth, R; Gass, J; Graham, S; Hutchcraft, A; Rabinow, B; Valaitis, P; Werling, J | 1 |
| Grippo, AJ; Scotti, MA | 1 |
| Al Nimer, F; Carlström, KE; Dominguez, CA; Lindblom, RP; Ortlieb Guerreiro-Cacais, A; Piehl, F; Zhang, XM | 1 |
| Bhang, SH; Jang, HK; Jin, M; Kang, S; Kim, BS; La, WG; Lee, S; Ma, YJ; Noh, SS; Park, J; Shin, JY | 1 |
| Bhatena, Z; Bulsara, T; Firozgary, B; Firozgary, G; Khumbatta, M; Robinson, P; Siller, R; Tweardy, DJ; Weinstock, J | 1 |
| Gao, X; Huang, Y; Liu, X; Ouyang, J; Wang, S; Yin, H | 1 |
| Corrigan, F; Turner, RJ; Vink, R | 1 |
| Dijkstra, JF; Duraku, LS; Holstege, JC; Schüttenhelm, BN; Walbeehm, ET | 1 |
| Auster, ME; Carvalho, E; Kafanas, A; Kearney, C; Kokkotou, E; Kuchibhotla, S; Leal, EC; LoGerfo, FW; Mooney, DJ; Pradhan-Nabzdyk, L; Tecilazich, F; Tellechea, A; Veves, A | 1 |
| Covenas, R; Esteban, F; Munoz, M; Redondo, M | 1 |
| Altdorfer, K; Fehér, E; Kispély, B | 1 |
| Lisowska, B; Lisowski, A; Siewruk, K | 1 |
| Bignami, F; Ferrari, G; Rama, P | 1 |
| Dong, J; Kong, L; Liu, B; Liu, J; Liu, Y; Luo, Q; Pang, Q; Wang, J; Xu, F; Zhang, H | 1 |
| Cerda-Cristerna, B; Chavarria-Bolaños, D; Flores-Reyes, H; Lombana-Sanchez, N; Pozos-Guillen, A | 1 |
| Hamity, MV; Hammond, DL; Li, Y; Maduka, UP; Walder, RY; White, SR | 1 |
| Hong, HS; Kim, S; Park, JH; Son, Y | 1 |
| Jung, Y; Kim, SH; Shafiq, M | 1 |
| Amagase, K; Horie, S; Kato, S; Matsumoto, K; Utsumi, D | 1 |
| Allan, ND; Burwash, L; Matheson-Bird, H; Olson, ME; Ralston, B | 1 |
| Hoheisel, U; Mense, S | 1 |
| Corrigan, F; Leonard, AV; Mander, KA; Vink, R | 1 |
| Hong, HS; Hwang, DY; Kim, S; Park, JH; Seo, EJ; Son, Y | 1 |
| Barrett, KE; Camilleri, M; Sellin, JH | 1 |
| Abou Alaiwa, M; Adam, RJ; Jaffer, O; Meyerholz, DK; Michalski, AS; Powers, LS; Price, MP; Reznikov, LR; Stoltz, DA; Welsh, MJ | 1 |
| Lampiasi, N; Montana, G | 1 |
| Borbély, É; Helyes, Z | 1 |
| Hiller, JG; Ho, KM; Kuruvilla, N; Millen, R; Ramsay, R; Riedel, B; Sampurno, S | 1 |
| Bartolomucci, A; Ciotti, MT; D'Amato, F; La Corte, G; Levi, A; Moles, A; Pavone, F; Possenti, R; Rizzi, R; Sacerdote, P | 1 |
| Ahn, ES; Han, DW; Hong, YW; Kim, H; Lee, JH; Min, KT; Park, S | 1 |
| Afacan, B; Balci, MK; Ercan, F; Erin, N; Ersoy, Y | 1 |
| Gibran, NS; Isik, FF; Kegel, G; Liang, Z; Muangman, P; Muffley, LA; Scott, JR; Sullivan, SR; Tamura, RN; Xie, C | 1 |
| Camargo, Lde L; Costa, SK; Denadai-Souza, A; Keeble, JE; Muscará, MN; Ribela, MT | 1 |
| Bhatia, M; Ramnath, RD; Sun, J; Tamizhselvi, R | 1 |
| Amin, M; Amin, S; Barbe, MF; Barr, AE; Clark, BD; Elliott, MB | 1 |
| De Ponti, F; Ursino, MG; Vasina, V | 1 |
| Dong, H; Geng, X; Lu, X; Yu, H; Zeng, Y; Zhang, L | 1 |
| Karagiannides, I; Pothoulakis, C | 1 |
| Cetin, ED; Eskin, M; Karul, A; Savk, E; Uslu, M | 1 |
| Barbosa, AL; Moraes, MO; Oliveira, GJ; Pinheiro, CA; Ribeiro, RA; Souza, MH; Vale, ML | 1 |
| Castro, D; Esteban, F; Gonzalez-Moles, MA; Martin-Jaen, Mdel M; Muñoz, M; Redondo, M; Ruiz-Avila, I | 1 |
| Adler, JE; Skoff, AM; Zhao, C | 1 |
| Chang, W; Chen, J; Hoyle, GW; Schlueter, CF | 1 |
| De Man, JG; De Winter, BY; Grundy, D; Pelckmans, PA; Timmermans, JP; Torfs, P; Van Marck, E; Van Nassauw, L; Van Op den Bosch, J | 1 |
| Clark, DJ; Guo, TZ; Kingery, WS; Li, WW; Oaklander, AL; Schmelz, M; Wang, L; Wei, T; Zhao, R | 1 |
| Hammond, DL; Zhang, L | 1 |
| Bucala, RJ; Meyer-Siegler, KL; Vera, PL; Wang, X | 1 |
| Brain, SD; Fernandes, ES; Schmidhuber, SM | 1 |
| Jiang, HJ; Lin, P; Mei, L; Pan, H; Wu, XY | 1 |
| Bhatia, M | 1 |
| Kong, LF; Li, QZ; Liu, XF; Zhang, BH; Zhang, SN; Zhong, ZS | 1 |
| Burkhard, FC; Draeger, A; Kessler, TM; Kuhn, A; Monastyrskaya, K; Sanchez Freire, V | 1 |
| Biavatti, MW; Bürger, C; Busnardo, TC; Claudino, VD; Dalmarco, EM; de Souza, MM; Fröde, TS; Mora, TC; Padoani, C | 1 |
| Andersen, ND; Cai, X; Guthrie, P; Logerfo, FW; Malek, J; Martin, M; Pradhan, L; Veves, A; Wu, S | 1 |
| Harano, N; Hidaka, K; Inenaga, K; Kai, A; Nakanishi, O; Ono, K | 1 |
| Langner, K; Schuberth, HJ; Seyfert, HM; Sipka, A | 1 |
| Ciruela, F; Fernández-Dueñas, V; Gandía, J; Planas, E; Poveda, R; Sánchez, S | 1 |
| Chaban, VV | 1 |
| Back, W; de Grauw, JC; L'ami, JJ; van Dierendonck, M; van Loon, JP; van Weeren, PR | 1 |
| Ikeda, T; Matsushima, O; Naono-Nakayama, R; Nishimori, T; Sunakawa, N | 2 |
| Antal, M; Holló, K; Papp, I | 1 |
| Dubner, R; Guo, W; Lagraize, SC; Ren, K; Wei, F; Yang, K | 1 |
| Dubois, D; Gendron, L | 1 |
| Douglas, SD; Leeman, SE | 1 |
| Chakraborty, S; Davis, MJ; Muthuchamy, M; Nepiyushchikh, Z; Zawieja, DC | 1 |
| Fitzsimmons, B; Hua, XY; Newton, AC; O'Neill, A; Steinauer, J; Xu, Q; Yaksh, TL | 1 |
| Hu, C; Huang, S; Pan, P | 1 |
| Chmielinska, JJ; Kramer, JH; Mak, IT; Weglicki, WB | 1 |
| Anderson, MB; Hoffman, EM; Miller, KE; Schechter, R; Zhang, Z | 1 |
| Barbosa, S; Fernández-Blanco, JA; Martínez, V; Sánchez de Medina, F; Vergara, P | 1 |
| Ang, SF; Bhatia, M; MacAry, PA; Moochhala, SM | 1 |
| Bie, B; Zhao, ZQ | 1 |
| Chen, JC; Lin, YT; Ro, LS; Wang, HL | 1 |
| Ikeda, T; Naono-Nakayama, R; Nishimori, T; Sunakawa, N | 1 |
| Akasaka, Y; Hatta, A; Inoue, H; Sakai, A; Suzuki, H; Takasu, K; Tsukahara, M | 1 |
| Avelino, A; Bjorling, DE; Cruz, F; Davis, CA; Hurst, RE; Maier, J; Saban, MR; Saban, R; Sferra, TJ | 1 |
| Henry, PJ; Mann, TS; Taylor, SJ | 1 |
| Becker, C; Engel, MA; Khalil, M; Mueller-Tribbensee, SM; Neuhuber, WL; Neurath, MF; Reeh, PW | 1 |
| Brock, GR; Carlile, MJ; Chapple, IL; Kinane, D; Linden, GJ; Lorraine Martin, S; Lundy, FT; Matthews, JB; Milward, M; Naeeni, MA; Scott, AE; Walker, B | 1 |
| Abe, H; Hisaoka, K; Miyano, K; Morioka, N; Nakamura, Y; Nakata, Y; Une, Y | 1 |
| Jia, MM; Li, XJ; Li, YS; Liu, M; Tang, HB; Wang, JX | 1 |
| Harbuz, MS; Jessop, DS | 1 |
| Levrini, L; Sacerdote, P | 1 |
| Thornton, E; Vink, R | 1 |
| Berger, M; Muñoz, M; Rosso, M | 1 |
| Li, H; Li, YQ; Luo, Y; Sun, ZS; Teng, H; Zhang, J; Zhang, T; Zhao, M | 1 |
| Ghabriel, MN; Harford-Wright, E; Lewis, KM; Vink, R | 1 |
| Ahn, W; Chi, GF; Choi, H; Chung, E; Hong, HS; Jiang, MH; Kim, DW; Kim, J; Lim, JE; Son, Y | 1 |
| Arcanjo, DD; Guimarães, AG; Machado, FD; Oliveira, FA; Oliveira, RC; Quintans-Júnior, LJ; Silva, ER; Silva, FV; Sousa-Neto, BP | 1 |
| Ashikawa, M; Chiwaki, F; Furuta, S; Hasegawa, M; Kawamata, T; Matoba, M; Miyano, K; Narita, M; Ochiya, T; Sasaki, H; Suzuki, M; Suzuki, T; Uezono, Y; Yanagihara, K | 1 |
| Bianchi, C; Chu, LM; Clements, RT; Dobrilovic, N; Feng, J; Fingleton, JG; Liu, Y; Sellke, FW; Singh, AK | 1 |
| Braun, A; Rochlitzer, S; Spies, E; Veres, TZ; Voedisch, S | 1 |
| Chichorro, JG; Martini, AC; Rae, GA; Teodoro, FC; Tronco Júnior, MF; Zampronio, AR | 1 |
| Blackabey, V; Denes, A; Gittens, B; Pinteaux, E; Rodriguez-Grande, B | 1 |
| Guo, JX; Lu, GS; Song, B; Zhang, QH; Zhou, ZS | 1 |
| Cai, Y; Evensjö, M; Kovács, KJ; Larson, AA; McCarson, KE; Shi, Q; Velázquez, RA | 1 |
| Geisslinger, G; Meller, ST; Tegeder, L; Zimmermann, J | 1 |
| Braun, A; Dinh, QT; Fischer, A; Groneberg, DA; Kerzel, S; Nockher, WA; Päth, G; Quarcoo, D; Raap, U; Renz, H | 1 |
| Arck, PC; Fischer, A; Hagen, E; Handjiski, B; Klapp, BF; Paus, R; Peter, AS; Peters, EM | 1 |
| Bayer, MK; Chavolla-Calderón, M; Fontán, JJ | 1 |
| Castranova, V; Dey, RD; Frazer, DG; Sikora, ER; Stone, S; Tomblyn, S | 1 |
| Davies, C; Harrison, NK; Hilldrup, S; Hope-Gill, BD; Newton, RP | 1 |
| Calcutt, NA; Campana, WM; Catalano, R; Feng, Y; Freshwater, JD; Marsala, M; Protter, AA; Scott, B; Svensson, CI; Westerlund, A; Yaksh, TL | 1 |
| Dreyer, J; Hirlinger, D; Kuner, R; Müller-Esterl, W; Oess, S | 1 |
| Fehrenbacher, JC; Taylor, CP; Vasko, MR | 1 |
| Gustafsson, H; Hole, K; Kjørsvik Bertelsen, A; Stiller, CO; Tjølsen, A; Warsame Afrah, A | 1 |
| Eisenach, JC; Ma, W | 1 |
| Ahmadiani, A; Ebtekar, M; Sabahi, F; Yaraee, R | 1 |
| Del Turco, D; Deller, T; Feil, R; Geisslinger, G; Hofmann, F; Ruth, P; Sausbier, M; Schmidtko, A; Tegeder, I | 1 |
| Weinstock, JV | 1 |
| Hall, M; Masella, R; Meister, M | 1 |
| Bergquist, J; Svensson, L; Wennerås, C | 1 |
| Karimi, K; Kool, M; Nijkamp, FP; Redegeld, FA | 1 |
| Blum, AM; Elliott, DE; Metwali, A; Setiawan, T; Weinstock, JV | 1 |
| Duffy, RA | 1 |
| Anton, PM; Brown, D; Gay, J; Karalis, K; Mykoniatis, A; O'Brien, M; Pan, A; Pothoulakis, C | 1 |
| Holthaus, R; Kato, A; Lentsch, AB; Okaya, T | 1 |
| Chmielinska, JJ; Gonzalez, G; Mak, IT; Tejero-Taldo, MI; Weglicki, WB | 1 |
| Carlton, SM; Castañeda-Hernandez, G; Du, J; Grady, JJ; Jimenez-Andrade, JM; Yamani, A; Zhou, S | 1 |
| Bredin, CP; Goode, T; O'Brien, DI; O'Connell, J; O'Connor, TM; Shanahan, F | 1 |
| Marriott, I | 1 |
| Bost, KL | 1 |
| Balhorn, A; Dakhama, A; El Gazzar, M; Gelfand, EW; Joetham, A; Kanehiro, A; Kodama, T; Larsen, GL; Loader, JE; Miyahara, N; Park, JW; Takeda, K; Taube, C | 1 |
| Arsenescu, R; Blum, AM; Elliott, DE; Metwali, A; Weinstock, JV | 1 |
| Alt, W; Arnold, R; Heymann-Monnikes, I; Klapp, BF; McGregor, GP; Mönnikes, H; Tebbe, JJ; van der Voort, IR; Wiedenmann, B; Wollenberg, B | 1 |
| Berman, BM; Lao, L; Liu, B; Qiao, JT; Ren, K; Wang, L; Zhang, RX | 2 |
| Dennis, EA; Hua, XY; Lucas, KK; Powell, HC; Svensson, CI; Yaksh, TL | 1 |
| Chien, CT; Li, PC; Li, SC; Liang, JT; Lin, YJ; Shaw, CF | 1 |
| Ahern, GP; O'Connell, PJ; Pingle, SC | 1 |
| Brain, SD; Costa, SK; Muscará, MN; Poston, RN; Yshii, LM | 1 |
| Arck, PC; Blois, S; Labuz, D; Orsal, AS; Peters, EM; Schaefer, M | 1 |
| Fiebich, BL; Herpfer, I; Kirschbaum, C; Lieb, K; Rohleder, N; Wolf, JM | 1 |
| Khalil, Z; Nyberg, F; Wiktelius, D | 1 |
| Liu, G; Wen, W; Wu, G; Yan, Z; Zhang, R | 1 |
| Galkowska, H; Karnafel, W; Olszewski, WL; Rosinski, G; Wojewodzka, U | 1 |
| Fernández, E; Jiménez, M; Tanović, A | 1 |
| Inoue, A; Nakata, Y | 1 |
| Guan, C; Luo, Z; Qi, M; Qin, X; Wu, H; Xiang, Y; Zhang, C | 1 |
| Komarov, AM; Kramer, JH; Mak, IuT; Tejero-Taldo, MI; Weglicki, WB | 1 |
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| Arashidani, K; Fujimaki, H; Hojo, R; Kunugita, N; Sato, F; Yamamoto, S | 1 |
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| Al-Tawil, R; El-Nour, H; Granlund, A; Lonne-Rahm, SB; Lundeberg, L; Nordlind, K | 1 |
| Börzsei, R; Elekes, K; Helyes, Z; Kereskai, L; Németh, J; Pintér, E; Pozsgai, G; Sándor, K; Szabó, A; Szolcsányi, J | 1 |
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| Ikeda, Y; Ishige, A; Mase, A; Matsumoto, C; Takeda, S; Takei, H; Watanabe, K; Yamamoto, M | 1 |
| Bianchi, M; Ferrario, P; Franchi, S; Sacerdote, P; Sotgiu, ML | 1 |
| Fröde, TS; Goulart, S; Lang, KL; Liz, R; Moritz, MI; Schenkel, EP | 1 |
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| Brain, SD; Kofler, B; Schmidhuber, SM; Starr, A; Wynick, D | 1 |
| Koeda, T; Mizumura, K; Sato, J; Tamura, R | 1 |
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| Kozlova, IV; Volkov, SV | 1 |
| Hendrix, S; Magerl, M; Maurer, M; Metz, M; Peters, EM; Siebenhaar, F | 1 |
| Danoff, JV; Desai, MJ; Gerber, LH; Nakamura, LY; Parikh, S; Phillips, TM; Shah, JP | 1 |
| Baran, E; Salomon, J | 1 |
| Hama, A; Herzberg, U; Sagen, J | 1 |
| Blömer, U; Held-Feindt, J; Juraschek, M; Knerlich-Lukoschus, F; Lucius, R; Mehdorn, HM | 1 |
| Haraguchi, R; Iwanaga, T; Kubo, H; Muraki, M; Tohda, Y | 1 |
| Brodsky, B; Erlanger-Rosengarten, A; Proscura, E; Shapira, E; Wormser, U | 1 |
| Bhatia, M; Moochhala, SM; Ng, SW; Sidhapuriwala, JN; Tamizhselvi, R | 1 |
| Jung, HD; Kim, BS; Kim, DW; Lee, HJ; Lee, SJ; Lee, WJ | 1 |
| Gibson, SJ; McMahon, SB; Sykova, E; Wall, PD; Woolf, CJ | 1 |
| Folkers, K; Håkanson, R; Holmdahl, G; Leander, S; Rosell, S; Sundler, F | 1 |
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| Cassidy, MM; Dickens, BF; Kramer, JH; Mak, IT; Phillips, TM; Stafford, R; Weglicki, WB | 1 |
| Baluk, P; Bowden, JJ; Bunnett, NW; Garland, AM; Grady, EF; Lefevre, P; McDonald, DM; Vigna, SR | 1 |
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| Doubell, TP; Leslie, T; Neumann, S; Woolf, CJ | 1 |
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| Fischer, A; Kummer, W; McGregor, GP; Philippin, B; Saria, A | 1 |
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| Barrett, LT; May, SW; Moore, AB; O'Bryant, CL; Ogonowski, AA; Pollock, SH | 1 |
| Baluk, P; Bowden, JJ; Bunnett, NW; McDonald, DM | 1 |
| Hore, SK; Kumar, D; Tandan, SK; Tripathi, HC | 1 |
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| Braun, RK; Hyde, DM; Kabbur, MB; McDonald, RJ; Schrenzel, MD; Sterner-Kock, A; van der Vliet, A; Vulliet, PR | 1 |
| Allen, BJ; Finke, MP; Ghilardi, JR; Honore, P; Lappi, DA; Li, J; Luger, NM; Mantyh, PW; Nichols, ML; Rogers, SD; Simone, DA | 1 |
| Brain, SD | 1 |
| Amadesi, S; Bunnett, NW; Caughey, GH; Ennes, HS; Geppetti, P; Hollenberg, MD; Mayer, EA; Mitchell, SE; Steinhoff, M; Tognetto, M; Trevisani, M; Vergnolle, N; Wallace, JL; Williams, LM; Young, SH | 1 |
| Angelici, O; Bonanno, G; Carità, F; Clarke, GD; Raiteri, M; Schmid, G; Zaratin, P | 1 |
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| Herrero, JF; Laird, JM; López-García, JA | 1 |
| Forsgren, S; Franzén, L; Höckerfelt, U; Kjörell, U | 1 |
| Bunnett, NW; Gerard, C; Gerard, N; Grady, EF; Kim, EH; Kirkwood, KS; Maa, J; Rahim, S; Valeroso, D; Vartanian, RK; Yoshimi, SK | 1 |
| Cervero, F; De Felipe, C; Hunt, SP; Laird, JM; Olivar, T; Roza, C | 1 |
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| Ito, T; Kawai, Y; Tamura, T; Yonehara, N; Yoshimura, M | 1 |
| Linden, DR; McCarson, KE; Reutter, MA; Seybold, VS | 1 |
| Adelson, DW; Kruger, L; Maidment, NT; Matsuka, Y; Neubert, JK; Spigelman, I | 1 |
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| Farber, EM; Raychaudhuri, SP | 1 |
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| Blakeman, KH; Ernfors, P; Hao, JX; Hassani, H; Lucas, G; Naveilhan, P; Thorén, P; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Andrade-Gordon, P; Basbaum, AI; Brussee, V; Bunnett, NW; Cirino, G; Compton, SJ; Gerard, N; Grady, EF; Hollenberg, MD; Sharkey, KA; Vergnolle, N; Wallace, JL | 1 |
| Gillard, SE; Hammond, DL; Hurley, RW; Miller, RJ; Oh, SB; Tran, PB | 1 |
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| Averbeck, B; Cirillo, R; Evangelista, S; Fetzer, S; Kress, M; Lippi, A; Maggi, CA; Manzini, S; Reeh, PW; Sauer, SK; Vieira, C | 1 |
| de Weille, J; Lazdunski, M; Mamet, J; Voilley, N | 1 |
| Xu, GY; Zhao, ZQ | 1 |
| Befort, K; Brenner, GJ; Ji, RR; Woolf, CJ | 1 |
| Black, PH; Garbutt, LD | 1 |
| Corsani, L; Faussone-Pellegrini, MS; Fioramonti, J; Gay, J; Vannucchi, MG | 1 |
| Carini, F; Catalioto, RM; Giuliani, S; Lecci, A; Maggi, CA; Santicioli, P; Tramontana, M | 1 |
| Bianchi, M; Ferrario, P; Gaspani, L; Limiroli, E | 1 |
| Eysselein, VE; Gerken, G; Goebell, H; Hoffmann, P; Holtmann, G; Mazurkiewicz, J | 1 |
| Herbert, MK; Holzer, P | 1 |
| Anderson, LJ; Haynes, LM; Tonkin, J; Tripp, RA | 1 |
| Chahl, LA | 1 |
| Fazekas, A; Györfi, A; Rosivall, L | 1 |
| Galli, SJ; Geissler, EN; Gordon, JR; Tsai, M; Wershil, BK | 1 |
| Chrousos, GP; Crofford, LJ; Goldmuntz, EA; Karalis, K; Sano, H; Webster, EL; Wilder, RL | 1 |
| Handwerker, HO; Kessler, W; Kirchhoff, C; Reeh, PW | 1 |
| Håkanson, R; Wallengren, J | 1 |
| Abramson, SB; Cronstein, BN; Haines, KA; Kolasinski, SL; Siegel, EL | 1 |
| Hylden, JL; Noguchi, K; Ruda, MA | 1 |
| Baluk, P; McDonald, DM; Nadel, JA | 1 |
| Donnerer, J; Lembeck, F; Nagahisa, A; Tsuchiya, M | 1 |
| Garry, MG; Hargreaves, KM | 1 |
| Brokaw, JJ; White, GW | 1 |
| Donnerer, J; Schuligoi, R; Stein, C | 1 |
| Hrabec, E; Hrabec, Z | 1 |
| Phillips, TM; Weglicki, WB | 1 |
| Bloch, JG; Bronner, C; Bueb, JL; Landry, Y; Mousli, M | 1 |
| Herbort, CP; Mochizuki, M; Nishi, M; Okumura, A | 1 |
| Mantione, CR; Rodriguez, R | 1 |
| Dalsgaard, CJ; Haegerstrand, A; Laurenzi, MA; Persson, MA | 1 |
| McDonald, DM; Nadel, JA; Umeno, E | 1 |
| Kaliner, MA; Kowalski, ML; Sliwinska-Kowalska, M | 1 |
| Skerrett, PJ | 1 |
| Balu, A; De Sanctis, GT; Fick, G; Green, F; Lopez, A; Prior, M | 1 |
| Helme, RD; Khalil, Z | 4 |
| De, AK; Ghosh, JJ | 1 |
| Duggan, AW; Hope, PJ; Jarrott, B; Schaible, HG | 1 |
| Glinska-Ferenz, M; Glinski, W; Pierozynska-Dubowska, M | 1 |
| Cramer, R; Dri, P; Patriarca, P; Romano, M; Spessotto, P | 1 |
| Gill, BK; Nakamura-Craig, M | 1 |
| Amico-Roxas, M; Caruso, A; Clementi, G; Cutuli, V; Fiore, CE; Prato, A | 1 |
| Barnes, PJ | 1 |
| Baumgarten, C; Brunnee, T; Kleine-Tebbe, J; Kunkel, G; Nieber, K; Oehme, P; Rathsack, R; Witzel, A | 1 |
| Abelli, L; Conte, B; Geppetti, P; Maggi, CA; Parlani, M; Somma, V | 1 |
| Andersson, RG; Lindgren, BR; Persson, K; Rosenqvist, U | 1 |
| Alving, K; Lundberg, JM; Matran, R | 1 |
| Mantyh, PW | 1 |
| Büchler, M; Friess, H; Müller, S; Nohr, D; Weihe, E; Zentel, HJ | 1 |
| Brodda-Jansen, G; Hedqvist, P; Lundeberg, T; Raud, J; Theodorsson, E | 1 |
| Folkers, K; Håkanson, R; Hao, JX; Hökfelt, T; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Thomsen, MK | 1 |
| Fujita, H; Kawabata, S; Kuraishi, Y; Matsumoto, T; Nakamura, A; Satoh, M | 1 |
| Ferrell, WR; Lam, FY | 2 |
| Amann, R; Donnerer, J; Lembeck, F | 1 |
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| Helme, RD; White, DM | 1 |
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| Denko, CW; Gabriel, P | 1 |
| Andrews, PV; Helme, RD; Watson, BA | 1 |
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| Joos, G; Kips, J; Pauwels, R; Van der Straeten, M | 1 |
| Inoki, R; Ohkubo, T; Shibata, M; Takahashi, H | 1 |
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| Foreman, JC | 3 |
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| Gamse, R; Jancsó, G; Posch, M; Saria, A | 1 |
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80 review(s) available for substance p and Inflammation
| Article | Year |
|---|---|
Role of Hydrogen Sulfide, Substance P and Adhesion Molecules in Acute Pancreatitis.
Topics: Cell Adhesion Molecules; Endothelial Cells; Humans; Hydrogen Sulfide; Inflammation; Integrins; Leukocytes; Pancreatitis; Selectins; Substance P | 2021 |
Substance P and Neurokinin 1 Receptor in Chronic Inflammation and Cancer of the Head and Neck: A Review of the Literature.
Topics: Cell Proliferation; Humans; Inflammation; Neoplasms; Receptors, Neurokinin-1; Substance P | 2021 |
Neuro-allergology: Mast cell-nerve cross-talk.
Topics: Cell Communication; Humans; Hypersensitivity; Inflammation; Lung; Mast Cells; Substance P | 2022 |
Activation of Mast Cells by Neuropeptides: The Role of Pro-Inflammatory and Anti-Inflammatory Cytokines.
Topics: Animals; Cytokines; Humans; Inflammation; Mast Cells; Mice; Neuropeptides; Rats; Substance P; Tumor Necrosis Factor-alpha | 2023 |
Inflammation and Organ Injury the Role of Substance P and Its Receptors.
Topics: Animals; Inflammation; Mice; Receptors, G-Protein-Coupled; Receptors, Neurokinin-1; Receptors, Neuropeptide; Substance P | 2023 |
Role of Substance P Neuropeptide in Inflammation, Wound Healing, and Tissue Homeostasis.
Topics: Animals; Cornea; Homeostasis; Humans; Inflammation; Insulin-Like Growth Factor I; Mice; Nervous System; Neuroimmunomodulation; Neurotransmitter Agents; Receptors, Neurokinin-1; Signal Transduction; Substance P; Wound Healing | 2017 |
Emerging Roles for MAS-Related G Protein-Coupled Receptor-X2 in Host Defense Peptide, Opioid, and Neuropeptide-Mediated Inflammatory Reactions.
Topics: Analgesics, Opioid; Animals; Antimicrobial Cationic Peptides; Asthma; Cathelicidins; Cell Transdifferentiation; Chymases; Humans; Immunity, Innate; Inflammation; Mast Cells; Nerve Tissue Proteins; Organ Specificity; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Substance P; Tryptases | 2017 |
Substance P and fibrotic diseases.
Topics: Animals; Corneal Diseases; Fibrosis; Heart Diseases; Humans; Inflammation; Joint Diseases; Kidney Diseases; Liver Cirrhosis; Primary Myelofibrosis; Substance P; Wound Healing | 2019 |
Substance P at the neuro-immune crosstalk in the modulation of inflammation, asthma and antimicrobial host defense.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Antimicrobial Cationic Peptides; Asthma; Drug Design; Host-Pathogen Interactions; Humans; Inflammation; Inflammation Mediators; Signal Transduction; Substance P | 2014 |
Involvement of substance P and the NK-1 receptor in human pathology.
Topics: Alcoholism; Animals; Bacterial Infections; Depression; Humans; Inflammation; Migraine Disorders; Neoplasms; Pain; Receptors, Neurokinin-1; Seizures; Stress, Psychological; Substance P; Virus Diseases; Vomiting | 2014 |
Tachykinin peptide, substance P, and its receptor NK-1R play an important role in alimentary tract mucosal inflammation during cytotoxic therapy.
Topics: Antineoplastic Agents; Gastrointestinal Diseases; Humans; Inflammation; Intestinal Mucosa; Receptors, Neurokinin-1; Substance P | 2014 |
Stress and neuroinflammation.
Topics: Animals; Catecholamines; Cyclooxygenase 2; Cytokines; Glucocorticoids; Humans; Inflammation; Nervous System Diseases; Neuropeptide Y; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Stress, Psychological; Substance P | 2013 |
Inflammation in acute CNS injury: a focus on the role of substance P.
Topics: Animals; Central Nervous System; Humans; Inflammation; Neurokinin-1 Receptor Antagonists; Substance P | 2016 |
The substance P/NK-1 receptor system: NK-1 receptor antagonists as anti-cancer drugs.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Apoptosis; Aprepitant; Cell Movement; Cell Proliferation; Emotions; Humans; Inflammation; Morpholines; Neoplasms; Neovascularization, Pathologic; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Substance P | 2015 |
Substance P and its Inhibition in Ocular Inflammation.
Topics: Animals; Disease Models, Animal; Eye Diseases; Humans; Inflammation; Neuropeptides; Receptors, Neurokinin-1; Substance P | 2016 |
Neurogenic inflammation after traumatic brain injury and its potentiation of classical inflammation.
Topics: Animals; Blood-Brain Barrier; Brain Injuries, Traumatic; Humans; Inflammation; Neurogenic Inflammation; Neuroglia; Neurons; Substance P; Transient Receptor Potential Channels | 2016 |
Pathophysiology, Evaluation, and Management of Chronic Watery Diarrhea.
Topics: C-Reactive Protein; Chromogranins; Chronic Disease; Diarrhea; Feces; Gastrointestinal Motility; Humans; Inflammation; Intestinal Absorption; Intestinal Mucosa; Intestinal Secretions; Intestines; Irritable Bowel Syndrome; Lactoferrin; Leukocyte L1 Antigen Complex; Osmolar Concentration; Permeability; Prostaglandins; Serotonin; Substance P | 2017 |
Role of hemokinin-1 in health and disease.
Topics: Animals; Humans; Inflammation; Pain; Receptors, Neurokinin-1; Signal Transduction; Substance P; Tachykinins | 2017 |
Substance P, obesity, and gut inflammation.
Topics: Adipose Tissue; Developed Countries; Gastrointestinal Diseases; Humans; Inflammation; Inflammatory Bowel Diseases; Obesity; Substance P | 2009 |
Sensory-nerve-derived neuropeptides: possible therapeutic targets.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Calcitonin Gene-Related Peptide; Galanin; Humans; Inflammation; Inflammation Mediators; Neuralgia; Neuropeptides; Receptors, G-Protein-Coupled; Sensory Receptor Cells; Signal Transduction; Substance P; Tachykinins | 2009 |
Hydrogen sulfide and substance P in inflammation.
Topics: Air Pollutants; Amino Acid Sequence; Animals; Humans; Hydrogen Sulfide; Inflammation; Inflammation Mediators; Molecular Sequence Data; Pain; Pancreatitis; Receptors, Neurokinin-1; Sepsis; Substance P; Syndrome; Systemic Inflammatory Response Syndrome | 2010 |
Neurokinin-1 receptor: functional significance in the immune system in reference to selected infections and inflammation.
Topics: Amino Acid Sequence; Animals; Humans; Infections; Inflammation; Inflammation Mediators; Molecular Sequence Data; Protein Isoforms; Receptors, Neurokinin-1; Substance P | 2011 |
Cardiovascular and intestinal responses to oxidative and nitrosative stress during prolonged magnesium deficiency.
Topics: Animals; Cardiovascular System; Humans; Inflammation; Intestinal Mucosa; Intestines; Magnesium Deficiency; Neprilysin; Oxidative Stress; Rats; Reactive Nitrogen Species; Receptors, Immunologic; Receptors, N-Methyl-D-Aspartate; Substance P | 2011 |
Stress and inflammatory disease: widening roles for serotonin and substance P.
Topics: Acute Disease; Animals; Chronic Disease; Humans; Hypothalamo-Hypophyseal System; Inflammation; Inflammation Mediators; Pituitary-Adrenal System; Serotonin; Stress, Physiological; Stress, Psychological; Substance P | 2001 |
Peripheral mechanisms of dental pain: the role of substance P.
Topics: Humans; Inflammation; Substance P; Toothache | 2012 |
The role of neurokinin-1 receptor in the microenvironment of inflammation and cancer.
Topics: Emotions; Humans; Immunohistochemistry; Inflammation; Neoplasms; Receptors, Neurokinin-1; Substance P; Tumor Microenvironment | 2012 |
The role of substance P, hemokinin and their receptor in governing mucosal inflammation and granulomatous responses.
Topics: Animals; Chronic Disease; Gastroenteritis; Granuloma; Hepatitis; Humans; Immunity, Mucosal; Inflammation; Inflammatory Bowel Diseases; Mice; Protein Precursors; Receptors, Neurokinin-1; Substance P; Tachykinins | 2004 |
PDL neuron-associated neurotransmitters in orthodontic tooth movement: identification and proposed mechanism of action.
Topics: Calcitonin Gene-Related Peptide; Humans; Inflammation; Periodontal Ligament; Substance P; Tooth Movement Techniques | 2001 |
Potential therapeutic targets for neurokinin-1 receptor antagonists.
Topics: Analgesics; Anti-Anxiety Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Antiemetics; Antineoplastic Agents; Antitussive Agents; Anxiety; Asthma; Clinical Trials as Topic; Cough; Cystitis; Depression; Drug Design; Humans; Inflammation; Irritable Bowel Syndrome; Neoplasms; Neurokinin-1 Receptor Antagonists; Pain; Substance P; Vomiting | 2004 |
The role of substance P in inflammatory disease.
Topics: Animals; Digestive System; Humans; Inflammation; Pneumonia; Receptors, Tachykinin; Substance P | 2004 |
The role of tachykinins in central nervous system inflammatory responses.
Topics: Animals; Astrocytes; Central Nervous System; Humans; Inflammation; Microglia; Neurokinin A; Neurokinin B; Neurons; Oligodendroglia; Substance P; Tachykinins | 2004 |
Tachykinin-mediated modulation of the immune response.
Topics: Animals; Antiviral Agents; Bone Marrow; Hematopoietic Stem Cells; Humans; Immune System; Infections; Inflammation; Neurokinin A; Neurons; Receptors, Neurokinin-1; Substance P; T-Lymphocytes; Tachykinins | 2004 |
[Neurogenic inflammation facilitates neuropeptides release from primary afferent neurons].
Topics: Animals; Inflammation; Neurons, Afferent; Neuropeptides; Rats; Substance P | 2006 |
The nerve-heart connection in the pro-oxidant response to Mg-deficiency.
Topics: Animals; Antioxidants; Heart Failure; Humans; Inflammation; Magnesium Deficiency; Myocardium; Neurokinin-1 Receptor Antagonists; Neurons; Nitric Oxide; Oxidative Stress; Receptors, N-Methyl-D-Aspartate; Substance P | 2006 |
[Cytokine expression in GERD].
Topics: Anti-Inflammatory Agents; Antioxidants; Cytokines; Esophagoscopy; Esophagus; Gastroesophageal Reflux; Gene Expression; Humans; Inflammation; Inflammation Mediators; Interleukin-8; Nociceptors; Oxidative Stress; RNA, Messenger; Substance P | 2007 |
Substance P at the nexus of mind and body in chronic inflammation and affective disorders.
Topics: Adrenal Medulla; Asthma; Chronic Disease; Humans; Hypothalamo-Hypophyseal System; Inflammation; Mood Disorders; Pituitary-Adrenal System; Psychophysiology; Substance P | 2007 |
Modulation of immunity and hypersensitivity by sensory neuropeptides.
Topics: Humans; Hypersensitivity; Immunity, Cellular; Inflammation; Nerve Fibers; Nerve Tissue Proteins; Somatostatin; Substance P | 1984 |
[Polypeptides and antagonists].
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Captopril; Humans; Hypertension; Inflammation; Kallikreins; Kinins; Neurotensin; Peptides; Renin-Angiotensin System; Substance P; Vasoactive Intestinal Peptide | 1984 |
The enteric nervous and immune systems: interactions for mucosal immunity and inflammation.
Topics: Animals; Enteric Nervous System; Humans; Immunoglobulin A; Immunologic Memory; Inflammation; Inflammatory Bowel Diseases; Intestinal Mucosa; Mice; Neuroimmunomodulation; Neuropeptides; Peyer's Patches; Rats; Receptors, Neuropeptide; Substance P; Th2 Cells; Vasoactive Intestinal Peptide | 1994 |
Substance P and inflammatory pain: potential of substance P antagonists as analgesics.
Topics: Animals; Electrophysiology; Humans; Inflammation; Pain; Spinal Cord; Substance P; Synapses | 1993 |
Peptidase modulation of airway effects of neuropeptides.
Topics: Amino Acid Sequence; Animals; Humans; Inflammation; Molecular Sequence Data; Neprilysin; Neurokinin A; Neuropeptides; Respiratory Physiological Phenomena; Respiratory System; Substance P; Vasoactive Intestinal Peptide | 1993 |
Sensory nerve activation as a potential anti-inflammatory mechanism.
Topics: Animals; Calcitonin Gene-Related Peptide; Humans; Inflammation; Neurons, Afferent; Peripheral Nerves; Substance P | 1993 |
Upregulation, release and axonal transport of substance P and calcitonin gene-related peptide in adjuvant inflammation and regulatory function of nerve growth factor.
Topics: Adjuvants, Immunologic; Animals; Axonal Transport; Calcitonin Gene-Related Peptide; Ganglia, Spinal; Inflammation; Nerve Growth Factors; Neurons, Afferent; Rats; Sciatic Nerve; Skin; Spinal Cord; Substance P | 1993 |
The differential roles of substance P and neurokinin A in spinal cord hyperexcitability and neurogenic inflammation.
Topics: Afferent Pathways; Animals; Inflammation; Muscles; Neurokinin A; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Reflex; Skin; Spinal Cord; Substance P | 1993 |
Discovery of CP-96,345 and its characterization in disease models involving substance P.
Topics: Analgesics; Animals; Asthma; Binding, Competitive; Biphenyl Compounds; Disease Models, Animal; Inflammation; Pain; Receptors, Neurokinin-2; Substance P | 1993 |
Antinociceptive properties and inhibition of neurogenic inflammation with potent SP antagonists belonging to perhydroisoindolones.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Indoles; Inflammation; Isoindoles; Receptors, Neurokinin-2; Structure-Activity Relationship; Substance P; Tachykinins | 1993 |
Mouse mast cell cytokine production: rôle in cutaneous inflammatory and immunological responses.
Topics: Animals; Cell Division; Cytokines; Immunity; Inflammation; Mast Cells; Mice; Skin; Skin Physiological Phenomena; Substance P | 1995 |
Phenotypic modification of primary sensory neurons: the role of nerve growth factor in the production of persistent pain.
Topics: Animals; Ganglia, Spinal; Humans; Hyperalgesia; Inflammation; Models, Neurological; Nerve Growth Factors; Neurons, Afferent; Pain; Peripheral Nerves; Phenotype; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; Substance P | 1996 |
Neuroimmunomodulation: classical and non-classical cellular activation.
Topics: Adjuvants, Immunologic; Animals; Humans; Immunosuppressive Agents; Inflammation; Lymphocyte Activation; Mice; Models, Immunological; Models, Neurological; Neprilysin; Neuroimmunomodulation; Rats; Receptors, Tachykinin; Substance P; Sympathetic Nervous System | 1995 |
Lumbar facet pain: biomechanics, neuroanatomy and neurophysiology.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Biomechanical Phenomena; Humans; Inflammation; Lumbar Vertebrae; Male; Muscles; Nerve Fibers, Myelinated; Nervous System; Pain; Phospholipases A; Physical Stimulation; Rabbits; Substance P; Weight-Bearing | 1996 |
Neurogenic inflammation. A model for studying efferent actions of sensory nerves.
Topics: Afferent Pathways; Animals; Capillary Leak Syndrome; Capsaicin; Carotid Body; Efferent Pathways; Endothelium, Vascular; Guinea Pigs; Inflammation; Mycoplasma Infections; Neovascularization, Pathologic; Neurons, Afferent; Rats; Receptors, Neurokinin-1; Respiratory System; Respiratory Tract Diseases; Respiratory Tract Infections; Substance P; Venules | 1996 |
Pulmonary inflammation--a balancing act.
Topics: Antigens, CD; Complement C5a; Humans; Inflammation; Lung Diseases; Receptor, Anaphylatoxin C5a; Receptors, Complement; Receptors, Neurokinin-1; Substance P | 1997 |
Neuropeptides: mediators of inflammation and tissue repair?
Topics: Calcitonin Gene-Related Peptide; Cell Division; Immune System; Inflammation; Macrophages; Mast Cells; Monocytes; Neuropeptides; Peripheral Nervous System; Substance P; T-Lymphocytes; Wound Healing | 1998 |
Efferent functions of C-fiber nociceptors.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Efferent Pathways; Fibromyalgia; Humans; Inflammation; Nerve Fibers; Neurokinin A; Nociceptors; Skin; Substance P; Swine | 1998 |
Wind-up of spinal cord neurones and pain sensation: much ado about something?
Topics: Afferent Pathways; Analgesics; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cats; Humans; Hyperalgesia; Inflammation; Ion Transport; Models, Neurological; Morphine; Nerve Fibers; Nerve Tissue Proteins; Neuralgia; Neuronal Plasticity; Neurons, Afferent; Neuropeptides; Nociceptors; Pain; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Reflex; Spinal Cord; Substance P; Synaptic Transmission; Viscera | 2000 |
[Neural-immune interactions in dorsal root ganglia].
Topics: Animals; Cyclooxygenase 2; Ganglia; Humans; Hyperalgesia; Inflammation; Interleukin-1; Isoenzymes; Membrane Proteins; Neuroimmunomodulation; Neuropeptides; Prostaglandin-Endoperoxide Synthases; Spinal Nerve Roots; Substance P | 2000 |
Somatostatin and somatostatin receptors in the immune system: a review.
Topics: Animals; B-Lymphocytes; Humans; Immune System; Inflammation; Lymphocyte Activation; Models, Biological; Neuroimmunomodulation; Receptors, Somatostatin; Signal Transduction; Somatostatin; Substance P; T-Lymphocytes | 2000 |
Neurokinin mediation of edema and inflammation.
Topics: Animals; Edema; Humans; Inflammation; Neurokinin A; Neurokinin B; Substance P; Tachykinins | 2000 |
Neurochemical plasticity in persistent inflammatory pain.
Topics: Animals; Humans; Inflammation; Neuronal Plasticity; Pain; Posterior Horn Cells; Receptors, Neurokinin-1; Substance P | 2000 |
Stress, inflammation and cardiovascular disease.
Topics: Acute-Phase Proteins; Adrenal Cortex Hormones; Arteriosclerosis; Brain; Cardiovascular Diseases; Catecholamines; Cytokines; Fibrinolysis; Glucagon; Homocysteine; Human Growth Hormone; Humans; Inflammation; Intercellular Adhesion Molecule-1; Neurons; Renin; Risk Factors; Stress, Psychological; Substance P; Vascular Cell Adhesion Molecule-1 | 2002 |
[Neurogenic inflammation. I. Basic mechanisms, physiology and pharmacology].
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Humans; Inflammation; Nerve Fibers; Neuritis; Neurons, Afferent; Substance P | 2002 |
Neurogenic inflammation and the oral mucosa.
Topics: Capsaicin; Humans; Inflammation; Mouth Mucosa; Neurons, Afferent; Sensory Receptor Cells; Substance P; Vasodilation | 1992 |
Analyzing mast cell development and function using mice carrying mutations at W/c-kit or Sl/MGF (SCF) loci.
Topics: Animals; Chromosome Mapping; Hematopoietic Cell Growth Factors; Immunoglobulin E; Inflammation; Leukocytes; Mast Cells; Mice; Mutation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Skin; Stem Cell Factor; Substance P; Tumor Necrosis Factor-alpha | 1992 |
[Neurokinin receptors. The role of substance P in inflammatory processes].
Topics: Amino Acid Sequence; Amino Acids; Chemotaxis, Leukocyte; Humans; Inflammation; Molecular Sequence Data; Neutrophils; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P | 1992 |
Neurogenic inflammation in airways.
Topics: Animals; Epithelium; Humans; Inflammation; Neuropeptides; Respiratory System; Substance P; Tachykinins | 1991 |
Pulmonary physiology and pharmacology of neuropeptides.
Topics: Animals; Calcitonin Gene-Related Peptide; Humans; Hypersensitivity, Immediate; Inflammation; Lung; Neurokinin A; Neuropeptides; Substance P; Vasoactive Intestinal Peptide | 1991 |
Substance P and the inflammatory and immune response.
Topics: Animals; Central Nervous System; Humans; Immune System; Inflammation; Inflammatory Bowel Diseases; Neurons; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P | 1991 |
The tachykinin neuroimmune connection in inflammatory pain.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Genes, fos; Humans; Inflammation; Models, Neurological; Nervous System; Nervous System Physiological Phenomena; Neurons, Afferent; Neuropeptides; Pain; Rats; Substance P; Tachykinins | 1991 |
The putative role of neuropeptides in hyperreactivity and inflammation.
Topics: Eye; Humans; Inflammation; Nerve Tissue Proteins; Nervous System; Neurons, Afferent; Respiratory System; Skin; Substance P | 1985 |
The respiratory effects of neuropeptides.
Topics: Airway Resistance; Animals; Asthma; Bronchi; Humans; Inflammation; Kinins; Lung; Nerve Tissue Proteins; Substance P; Vasoactive Intestinal Peptide; Vasodilation | 1986 |
Neuropeptides and the pathogenesis of allergy.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Humans; Hypersensitivity; Inflammation; Mast Cells; Neurokinin A; Neuropeptides; Peripheral Nerves; Substance P | 1987 |
Substance P and calcitonin gene-related peptide: effects on mast cells and in human skin.
Topics: Animals; Histamine Release; Humans; Hypersensitivity, Immediate; Inflammation; Mast Cells; Neurons, Afferent; Rats; Receptors, Calcitonin; Receptors, Cell Surface; Skin; Substance P | 1987 |
Inflammatory mediators, tachykinins and enkephalinase in airways.
Topics: Endopeptidases; Histamine Release; Inflammation; Mast Cells; Neprilysin; Neuropeptides; Respiratory System; Substance P; Tachykinins | 1987 |
Substance P receptor-dependent responses of leukocytes in pulmonary inflammation.
Topics: Animals; Humans; Hypersensitivity, Immediate; Inflammation; Lung; Lymphocytes; Neuropeptides; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Tachykinins | 1987 |
Peptides and neurogenic inflammation.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Humans; Inflammation; Nervous System; Neuropeptides; Substance P | 1987 |
Dual roles of substance P: modulator of immune and neuroendocrine functions.
Topics: Animals; Humans; Hypersensitivity, Immediate; Immune System; Inflammation; Lymphocytes; Neurosecretory Systems; Substance P | 1987 |
Substance P: a modulator of neuroendocrine-immune function.
Topics: Animals; Humans; Hypersensitivity, Immediate; Immunity, Cellular; Inflammation; Lymphocytes; Receptors, Neurotransmitter; Substance P | 1989 |
Bidirectional regulatory circuit between the immune and neuroendocrine systems.
Topics: Animals; Feedback; Guinea Pigs; Homeostasis; Hormones; Humans; Hypersensitivity; Immune System; Inflammation; Interleukin-1; Lymphocytes; Mast Cells; Mice; Neurosecretory Systems; Neurotransmitter Agents; Receptors, Cell Surface; Substance P | 1989 |
Interaction of neuropeptides with human mast cells.
Topics: Histamine Release; Humans; Immunoglobulin E; In Vitro Techniques; Inflammation; Mast Cells; Neuropeptides; Prostaglandin D2; Skin; SRS-A; Substance P | 1989 |
Neuropeptides and inflammation: the role of substance P.
Topics: Animals; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Inflammation; Mononuclear Phagocyte System; Muscle, Smooth; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P | 1989 |
4 trial(s) available for substance p and Inflammation
| Article | Year |
|---|---|
Administration of acetylsalicylic acid after parturition in lactating dairy cows under certified organic management: Part II. Biomarkers of nociception, inflammation, and stress.
Topics: Animals; Aspirin; Biomarkers; Cattle; Cattle Diseases; Dystocia; Female; Haptoglobins; Hydrocortisone; Inflammation; Lactation; Milk; Nociception; Parity; Parturition; Pregnancy; Substance P | 2020 |
Impact of celecoxib on inflammation during cancer surgery: a randomized clinical trial.
Topics: Aged; Celecoxib; Cyclooxygenase 2 Inhibitors; Female; Follow-Up Studies; Humans; Inflammation; Male; Middle Aged; Neoplasms; Pain, Postoperative; Prospective Studies; Substance P | 2017 |
Intra-articular opioid analgesia is effective in reducing pain and inflammation in an equine LPS induced synovitis model.
Topics: Analgesics, Opioid; Animals; Bradykinin; Cross-Over Studies; Dinoprostone; Female; Horse Diseases; Horses; Inflammation; Injections, Intra-Articular; Lipopolysaccharides; Morphine; Pain; Proteins; Substance P; Synovial Fluid; Synovitis | 2010 |
Release of algesic substances in human experimental muscle pain.
Topics: Adult; Arm; Dinoprostone; Exercise; Female; Glutamic Acid; Humans; Hypertonic Solutions; Inflammation; Lactic Acid; Leg; Male; Microdialysis; Muscle Contraction; Muscle Fatigue; Muscle, Skeletal; Nitric Oxide; Pain; Pain Measurement; Sodium Chloride; Substance P; Time Factors | 2002 |
403 other study(ies) available for substance p and Inflammation
| Article | Year |
|---|---|
Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions.
Topics: Animals; Disease Models, Animal; Drug Hypersensitivity; Female; HEK293 Cells; Histamine Release; Humans; Inflammation; Male; Mast Cells; Mice; Mice, Knockout; Nerve Tissue Proteins; Receptors, G-Protein-Coupled; Receptors, Neuropeptide | 2015 |
Hypoglycemic Effect of Electroacupuncture at ST25 Through Neural Regulation of the Pancreatic Intrinsic Nervous System.
Topics: Animals; Blood Glucose; Calcitonin Gene-Related Peptide; Diabetes Mellitus, Experimental; Electroacupuncture; Hypoglycemia; Inflammation; Insulin; Insulin Resistance; Insulin-Secreting Cells; Rats; Rats, Sprague-Dawley; Substance P; TRPV Cation Channels | 2022 |
Substance P promotes the progression of bronchial asthma through activating the PI3K/AKT/NF-κB pathway mediated cellular inflammation and pyroptotic cell death in bronchial epithelial cells.
Topics: Animals; Asthma; Carrier Proteins; Caspase 1; Epithelial Cells; Humans; Inflammasomes; Inflammation; Interleukin-18; Lactate Dehydrogenases; Leukocytes, Mononuclear; Mice; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyroptosis; Receptors, Neurokinin-1; Substance P | 2022 |
Substance P Exacerbates the Inflammatory and Pro-osteoclastogenic Responses of Murine Osteoclasts and Osteoblasts to Staphylococcus aureus.
Topics: Animals; Inflammation; Mice; Neurokinin-1 Receptor Antagonists; Osteoblasts; Osteoclasts; Osteomyelitis; Staphylococcal Infections; Staphylococcus aureus; Substance P | 2023 |
Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection.
Topics: Animals; Dysbiosis; Gastrointestinal Microbiome; Inflammation; Inflammatory Bowel Diseases; Mice; Nociceptors; Substance P | 2022 |
Elucidating the Ability of CGRP to Modulate Microvascular Events in Mouse Skin.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Carrageenan; Edema; Inflammation; Mice; Mice, Knockout; Neuropeptides; Skin; Substance P; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2022 |
Role of Type I Cannabinoid Receptor in Sensory Neurons in Psoriasiform Skin Inflammation and Pruritus.
Topics: Animals; Eczema; Imiquimod; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Pruritus; Psoriasis; Receptors, Cannabinoid; Sensory Receptor Cells; Substance P | 2023 |
Neuropeptides, New Ligands of SARS-CoV-2 Nucleoprotein, a Potential Link between Replication, Inflammation and Neurotransmission.
Topics: COVID-19; Humans; Inflammation; Ligands; Neuropeptides; Nucleoproteins; Post-Acute COVID-19 Syndrome; SARS-CoV-2; Substance P; Synaptic Transmission | 2022 |
Changes in TRPV1 Expression as Well as Substance P and Vasoactive Intestinal Peptide Levels Are Associated with Recurrence of Pterygium.
Topics: Humans; Inflammation; Neuropeptides; Pterygium; Substance P; TRPV Cation Channels; Vasoactive Intestinal Peptide | 2022 |
The Src1-PGC1α-AP1 complex-dependent secretion of substance P induces inflammation and apoptosis in encephalomyocarditis virus-infected mice.
Topics: Animals; Apoptosis; Cytokines; Encephalomyocarditis virus; Inflammation; Mice; Myocarditis; Nuclear Receptor Coactivator 1; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Substance P; Transcription Factor AP-1 | 2023 |
Targeting NK-1R attenuates renal fibrosis
Topics: Animals; Fibrosis; Inflammation; Kidney; Mice; Receptors, Neurokinin-1; Renal Insufficiency, Chronic; Substance P; Ureteral Obstruction | 2023 |
Substance P-Mediated Vascular Protection Ameliorates Bone Loss.
Topics: Animals; Antioxidants; Bone Diseases, Metabolic; Endothelial Cells; Estrogens; Female; Inflammation; Nitric Oxide; Osteoporosis; Rats; Substance P; Vascular Diseases | 2023 |
Neurokinin-1 receptor is an effective target for treating leukemia by inducing oxidative stress through mitochondrial calcium overload.
Topics: Adult; Aged; Animals; Apoptosis; Calcium; Cell Line, Tumor; Female; Humans; Inflammation; Leukemia; Leukemia, Myeloid, Acute; Male; Mice; Mice, Inbred ICR; Middle Aged; Mitochondria; Neurokinin-1 Receptor Antagonists; Oxidative Stress; Receptors, Neurokinin-1; Signal Transduction; Substance P | 2019 |
Activation of mitogen-activated protein kinases in satellite glial cells of the trigeminal ganglion contributes to substance P-mediated inflammatory pain.
Topics: Animals; Inflammation; Mitogen-Activated Protein Kinases; Neuroglia; Neurons; p38 Mitogen-Activated Protein Kinases; Rats; Substance P; Trigeminal Ganglion | 2019 |
Modulatory effects of neuropeptides on pentylenetetrazol-induced epileptic seizures and neuroinflammation in rats.
Topics: Animals; Biomarkers; Calcitonin Gene-Related Peptide; Convulsants; Disease Models, Animal; Ghrelin; Inflammation; Interleukin-1beta; Male; Myoclonus; Neuropeptides; Pentylenetetrazole; Peptide Hormones; Random Allocation; Rats, Wistar; Seizures; Substance P; Time Factors; Vasoactive Intestinal Peptide | 2019 |
Tachykinin-1 receptor antagonism suppresses substance-P- and compound 48/80-induced mast cell activation from rat mast cells expressing functional mas-related GPCR B3.
Topics: Animals; Cell Degranulation; Dinitrophenols; Histamine Release; Humans; Inflammation; Male; Mast Cells; Mice; Nerve Tissue Proteins; Neurokinin-1 Receptor Antagonists; p-Methoxy-N-methylphenethylamine; Protein Conformation; Rats; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Serum Albumin, Bovine; Substance P; Tachykinins | 2020 |
Sensory neurons directly promote angiogenesis in response to inflammation via substance P signaling.
Topics: Animals; Corneal Neovascularization; Dry Eye Syndromes; Endothelial Cells; Inflammation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Receptors, Neurokinin-1; Sensory Receptor Cells; Signal Transduction; Substance P | 2020 |
Stress aggravates and prolongs imiquimod-induced psoriasis-like epidermal hyperplasis and IL-1β/IL-23p40 production.
Topics: Animals; Anxiety; Dendritic Cells; Dermatitis; Emotions; Epidermis; Hyperplasia; Imiquimod; Inflammation; Interleukin-12 Subunit p40; Interleukin-1beta; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Nociceptors; Psoriasis; Receptors, Neurokinin-1; Stress, Psychological; Substance P; Up-Regulation | 2020 |
Hemokinin-1 and substance P stimulate production of inflammatory cytokines and chemokines in human colonic mucosa via both NK
Topics: Adult; Aged; Aged, 80 and over; Chemokines; Cytokines; Female; Gene Expression; Humans; Inflammation; Inflammation Mediators; Intestinal Mucosa; Male; Middle Aged; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tachykinins | 2020 |
Neuroimmunomodulation in the mucosa of the alimentary tract
Topics: Animals; Immunohistochemistry; Inflammation; Nerve Fibers; Neuropeptide Y; Substance P; Vasoactive Intestinal Peptide | 2020 |
Elevated serum substance P during simian varicella virus infection in rhesus macaques: implications for chronic inflammation and adverse cerebrovascular events.
Topics: Animals; Biomarkers; Gene Expression; Herpesvirus 3, Human; Immunosuppressive Agents; Inflammation; Macaca mulatta; Male; Risk; Stroke; Substance P; Tacrolimus; Varicella Zoster Virus Infection; Virus Activation; Whole-Body Irradiation | 2020 |
Substance P Mediates Estrogen Modulation Proinflammatory Cytokines Release in Intervertebral Disc.
Topics: Animals; Biomarkers; Cytokines; Estrogens; Female; Immunohistochemistry; Inflammation; Intervertebral Disc Degeneration; Low Back Pain; Mice; Mice, Inbred C57BL; Nucleus Pulposus; Random Allocation; Real-Time Polymerase Chain Reaction; Substance P | 2021 |
Substance P enhances the therapeutic effect of MSCs by modulating their angiogenic potential.
Topics: Animals; Becaplermin; Dermis; Granulation Tissue; Immunosuppression Therapy; Inflammation; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice, Nude; Neovascularization, Physiologic; Paracrine Communication; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Substance P; Wound Healing | 2020 |
Continuous infusion of substance P inhibits acute, but not subacute, inflammatory pain induced by complete Freund's adjuvant.
Topics: Acute Disease; Analgesics; Animals; Corpus Striatum; Edema; Freund's Adjuvant; Hyperalgesia; Inflammation; Infusions, Parenteral; Male; Pain; Pain Threshold; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P | 2020 |
The potential anti-inflammatory and anti-nociceptive effects of rat hemopressin (PVNFKFLSH) in experimental arthritis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Behavior, Animal; Cytokines; Edema; Gait; Hemoglobins; Inflammation; Injections, Intra-Articular; Knee Joint; Leukocytes; Male; Nociceptive Pain; Peptide Fragments; Rats, Sprague-Dawley; Receptors, Calcitonin Gene-Related Peptide; Substance P | 2021 |
Substance P blocks ovariectomy-induced bone loss by modulating inflammation and potentiating stem cell function.
Topics: Animals; Female; Inflammation; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Dawley; Stem Cells; Substance P | 2020 |
Mass spectrometric studies on the peptide integrity of substance P and related human tachykinins in human biofluids.
Topics: Animals; Body Fluids; Brain; Humans; Inflammation; Mass Spectrometry; Peptides; Receptors, Neurokinin-1; Saliva; Semen; Substance P; Swine; Tachykinins | 2021 |
Substance-P prevents the cholestatic liver injury by regulating inflammatory responses.
Topics: Animals; Apoptosis; Cholestasis; Common Bile Duct; Gene Expression Regulation; Humans; Inflammation; Interleukin-10; Ligation; Liver; Liver Cirrhosis; Matrix Metalloproteinase 9; Rats; Substance P; T-Lymphocytes, Regulatory; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2021 |
Enhanced Neurokinin-1 Receptor Expression Is Associated with Human Dental Pulp Inflammation and Pain Severity.
Topics: Adolescent; Adult; Case-Control Studies; Dental Pulp; Female; Humans; Inflammation; Male; Pain; Pain Measurement; Receptors, Neurokinin-1; Substance P; Young Adult | 2021 |
Substance P and the neurokinin-1 receptor expression in dog ileum with and without inflammation.
Topics: Animals; Dog Diseases; Dogs; Enteric Nervous System; Female; Gene Expression; Ileum; Inflammation; Intestinal Mucosa; Male; Muscle, Smooth; Neurons; Nitrergic Neurons; Receptors, Neurokinin-1; Substance P | 2017 |
Topics: Acute Disease; Animals; Arachidonic Acids; Calcitonin Gene-Related Peptide; Disease Models, Animal; Dopamine; Inflammation; Lipopeptides; Lipopolysaccharides; Mice; Plasminogen Activator Inhibitor 1; Sepsis; Substance P; TRPV Cation Channels | 2017 |
Human microglia and astrocytes constitutively express the neurokinin-1 receptor and functionally respond to substance P.
Topics: Animals; Astrocytes; Brain; Cell Line; Humans; Inflammation; Macaca mulatta; Meningitis, Bacterial; Microglia; Organ Culture Techniques; Receptors, Neurokinin-1; Substance P | 2017 |
MicroRNA-31-3p Is Involved in Substance P (SP)-Associated Inflammation in Human Colonic Epithelial Cells and Experimental Colitis.
Topics: Animals; Cell Line; Colitis; Colon; Crohn Disease; Dextran Sulfate; Disease Models, Animal; Epithelial Cells; Humans; Inflammation; MAP Kinase Signaling System; Mice; MicroRNAs; Substance P | 2018 |
Serum substance P: an indicator of disease activity and subclinical inflammation in rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Female; Humans; Inflammation; Male; Middle Aged; Severity of Illness Index; Substance P; Ultrasonography; Young Adult | 2018 |
Effect of timing of subcutaneous meloxicam administration on indicators of pain after knife castration of weaned calves.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Canada; Cattle; Female; Haptoglobins; Hydrocortisone; Inflammation; Injections; Male; Meloxicam; Orchiectomy; Pain; Random Allocation; Substance P; Thiazines; Thiazoles; Weaning | 2017 |
Innervation Changes Induced by Inflammation in the Murine Vagina.
Topics: Animals; Calcitonin Gene-Related Peptide; Edema; Female; Freund's Adjuvant; Inflammation; Mice, Inbred C57BL; Neovascularization, Pathologic; Nerve Fibers; Substance P; Time Factors; Vagina; Vasoactive Intestinal Peptide | 2018 |
Substance P ameliorates tumor necrosis factor-alpha-induced endothelial cell dysfunction by regulating eNOS expression in vitro.
Topics: Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Neurotransmitter Agents; Nitric Oxide; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-akt; Signal Transduction; Substance P; Tumor Necrosis Factor-alpha | 2018 |
The flavonoid compound apigenin prevents colonic inflammation and motor dysfunctions associated with high fat diet-induced obesity.
Topics: Adipose Tissue; Animals; Apigenin; Body Weight; Colon; Diet, High-Fat; Eosinophils; Flavonoids; Gene Expression Regulation, Enzymologic; Inflammation; Interleukin-1beta; Interleukin-6; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; MicroRNAs; Motor Activity; Muscle, Smooth; Nitric Oxide Synthase Type II; Obesity; Organ Size; Substance P | 2018 |
Allergic Rhinitis in Rats Is Associated with an Inflammatory Response of the Hippocampus.
Topics: Animals; CD11 Antigens; Disease Models, Animal; Glial Fibrillary Acidic Protein; Hippocampus; Inflammation; Interleukin-6; Male; Ovalbumin; Rats; Rats, Sprague-Dawley; Rhinitis, Allergic; Substance P; Tumor Necrosis Factor-alpha | 2018 |
Females have stronger neurogenic response than males after non-specific nasal challenge in patients with seasonal allergic rhinitis.
Topics: Adult; Allergens; Female; Humans; Inflammation; Male; Mast Cells; Middle Aged; Models, Theoretical; Nasal Lavage; Nasal Mucosa; Nasal Provocation Tests; Pollen; Prevalence; Rhinitis, Allergic; Rhinitis, Allergic, Seasonal; Sex Factors; Substance P | 2018 |
The mucosal surfaces of both eyes are immunologically linked by a neurogenic inflammatory reflex involving TRPV1 and substance P.
Topics: Animals; Cell Line, Tumor; Dendritic Cells; Eye; Hypersensitivity; Inflammation; Lymph Nodes; Melanoma; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mucous Membrane; NF-kappa B; Signal Transduction; Substance P; T-Lymphocytes, Regulatory; TRPV Cation Channels | 2018 |
Neurokinin-1 Receptor Deficiency Improves Survival in Murine Polymicrobial Sepsis Through Multiple Mechanisms in Aged Mice.
Topics: Animals; Cecum; Chemokine CXCL2; Disease Models, Animal; Hemodynamics; Inflammation; Interleukin-6; Ligation; Mice; Mice, Knockout; Punctures; Receptors, Neurokinin-1; Sepsis; Substance P | 2019 |
Neuropeptides SP and CGRP Diminish the
Topics: A549 Cells; Antigens, CD; Calcitonin Gene-Related Peptide; Cell Adhesion Molecules; Epithelial Cells; GPI-Linked Proteins; Humans; Inflammation; Interleukin-1beta; Moraxella catarrhalis; Neutrophils; Pancreatic Elastase; Pulmonary Disease, Chronic Obstructive; Substance P | 2018 |
Sensory nerves mediate spontaneous behaviors in addition to inflammation in a murine model of psoriasis.
Topics: Animals; Calcitonin Gene-Related Peptide; Denervation; Disease Models, Animal; Diterpenes; Imiquimod; Inflammation; Male; Mice; Mice, Inbred C57BL; Psoriasis; Reactive Nitrogen Species; Reactive Oxygen Species; Sensory Receptor Cells; Skin; Substance P; TRPA1 Cation Channel; TRPV Cation Channels | 2019 |
Airway inflammation and injury in children with prevalent weakly acidic gastroesophageal refluxes.
Topics: Bronchoalveolar Lavage Fluid; Bronchoscopy; Child; Child, Preschool; Chronic Disease; Female; Gastroesophageal Reflux; Humans; Infant; Inflammation; Macrophages; Male; Pepsin A; Recurrence; Respiratory System; Respiratory Tract Diseases; Retrospective Studies; Substance P | 2018 |
Neuroimmune cross-talk in Helicobacter pylori infection: analysis of substance P and vasoactive intestinal peptide expression in gastric enteric nervous system.
Topics: Adult; Cohort Studies; Enteric Nervous System; Female; Gastric Mucosa; Helicobacter Infections; Humans; Inflammation; Male; Retrospective Studies; Substance P; Vasoactive Intestinal Peptide | 2018 |
Evidence for neurogenic inflammation in lichen planopilaris and frontal fibrosing alopecia pathogenic mechanism.
Topics: Adult; Aged; Aged, 80 and over; Alopecia; Biopsy; Calcitonin Gene-Related Peptide; Chronic Disease; Epidermis; Female; Humans; Immunohistochemistry; Inflammation; Lichen Planus; Lipid Metabolism; Lymphocytes; Male; Microscopy, Confocal; Middle Aged; Neurogenic Inflammation; Neuropeptides; Scalp; Scalp Dermatoses; Substance P | 2020 |
Tachykinin upregulation in atopic dermatitis.
Topics: Adult; Biopsy; Cross-Sectional Studies; Dermatitis, Atopic; Female; Humans; Inflammation; Male; Middle Aged; Nerve Fibers; Neurokinin A; Receptors, Neurokinin-1; Skin; Substance P; Surveys and Questionnaires; Up-Regulation; Young Adult | 2019 |
Substance-P Prevents Cardiac Ischemia-Reperfusion Injury by Modulating Stem Cell Mobilization and Causing Early Suppression of Injury-Mediated Inflammation.
Topics: Animals; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Inflammation; Interleukin-10; Lectins, C-Type; Male; Mannose Receptor; Mannose-Binding Lectins; Myocardial Infarction; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Substance P; Tumor Necrosis Factor-alpha | 2019 |
Substance P accelerates wound repair by promoting neovascularization and preventing inflammation in an ischemia mouse model.
Topics: Animals; Disease Models, Animal; Inflammation; Inflammation Mediators; Ischemia; Male; Mice; Mice, Inbred BALB C; Neovascularization, Physiologic; Neurotransmitter Agents; Skin; Substance P; Wound Healing | 2019 |
Effect of anti-reflux treatment on gastroesophageal reflux-associated chronic cough: Implications of neurogenic and neutrophilic inflammation.
Topics: Adult; Aged; Chronic Disease; Cough; Female; Gastroesophageal Reflux; Humans; Inflammation; Leukocyte Count; Male; Middle Aged; Neutrophils; Prospective Studies; Proton Pump Inhibitors; Rabeprazole; Severity of Illness Index; Sputum; Substance P; Treatment Outcome; Visual Analog Scale | 2020 |
Infrapatellar fat pad-derived MSC response to inflammation and fibrosis induces an immunomodulatory phenotype involving CD10-mediated Substance P degradation.
Topics: Adipose Tissue; Adult; Animals; Bone Marrow Cells; Cells, Cultured; Connective Tissue Growth Factor; Cytokines; Disease Models, Animal; Female; Fibrosis; Healthy Volunteers; Humans; Inflammation; Intercellular Signaling Peptides and Proteins; Interferon-gamma; Male; Mesenchymal Stem Cells; Middle Aged; Neprilysin; Phenotype; Proteolysis; Rats; Rats, Sprague-Dawley; Substance P; Synovitis; Tumor Necrosis Factor-alpha | 2019 |
Role of tachykinin 1 and 4 gene-derived neuropeptides and the neurokinin 1 receptor in adjuvant-induced chronic arthritis of the mouse.
Topics: Animals; Arthritis, Experimental; Edema; Freund's Adjuvant; Gene Expression Regulation; Hyperalgesia; Inflammation; Interleukin-1beta; Joints; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Plethysmography; Protein Precursors; Receptors, Neurokinin-1; Signal Transduction; Substance P; Tachykinins; Tarsus, Animal | 2013 |
Reduced expression of pain mediators and pain sensitivity in amyloid precursor protein over-expressing CRND8 transgenic mice.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Blotting, Western; Calcitonin Gene-Related Peptide; Freund's Adjuvant; Hot Temperature; Humans; Immunohistochemistry; Inflammation; Male; Mice; Mice, Transgenic; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Recovery of Function; Substance P; TRPV Cation Channels | 2013 |
Mechanism underlying anti-hyperalgesic and anti-allodynic properties of anomalin in both acute and chronic inflammatory pain models in mice through inhibition of NF-κB, MAPKs and CREB signaling cascades.
Topics: Acute Disease; Adenosine Triphosphate; Analgesics; Animals; Chronic Disease; Coumarins; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Hyperalgesia; Inflammation; Liver; Male; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase Type II; Nitrites; Pain; Signal Transduction; Substance P; Time Factors; Tumor Necrosis Factor-alpha | 2013 |
Substance P reduces apoptotic cell death possibly by modulating the immune response at the early stage after spinal cord injury.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cytokines; Inflammation; Male; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Substance P; Time Factors | 2013 |
Neuropeptide downregulation in sepsis.
Topics: alpha-MSH; Cohort Studies; Down-Regulation; Humans; Hydrocortisone; Inflammation; Melatonin; Neuropeptides; Neurotensin; Oxytocin; Prospective Studies; Shock, Septic; Substance P | 2014 |
Neutral endopeptidase regulates neurogenic inflammatory responses induced by stimulation of human oral keratinocytes with bacterial lipopolysaccharide and nicotine.
Topics: Aspartic Acid Endopeptidases; Cell Line; Down-Regulation; Endothelin-Converting Enzymes; Epithelial Cells; Humans; Inflammation; Interleukin-1beta; Keratinocytes; Lipopolysaccharides; Metalloendopeptidases; Mouth Mucosa; Neprilysin; Nicotine; Protease Inhibitors; RNA, Small Interfering; Substance P | 2013 |
Inflammation enhances Y1 receptor signaling, neuropeptide Y-mediated inhibition of hyperalgesia, and substance P release from primary afferent neurons.
Topics: Animals; Freund's Adjuvant; Guanosine 5'-O-(3-Thiotriphosphate); Hyperalgesia; In Vitro Techniques; Inflammation; Male; Neurons, Afferent; Neuropeptide Y; Pain Measurement; Pain Threshold; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neuropeptide Y; Signal Transduction; Spinal Cord; Spinal Nerve Roots; Substance P; Sulfur Isotopes | 2014 |
Glutamate, substance P, and calcitonin gene-related peptide cooperate in inflammation-induced heat hyperalgesia.
Topics: Androstanes; Animals; Benzimidazoles; Calcitonin Gene-Related Peptide; Female; Glutamic Acid; Hot Temperature; Hyperalgesia; Inflammation; Male; Mice; Nerve Growth Factor; Neurons, Afferent; Piperazines; Quinazolines; Substance P; TRPV Cation Channels; Vesicular Glutamate Transport Protein 2 | 2014 |
Trigeminal nerve stimulation triggers oral mast cell activation and vascular permeability.
Topics: Animals; Antipruritics; Capillary Permeability; Capsaicin; Evans Blue; Inflammation; Male; Mast Cells; Mouth; Rats; Rats, Sprague-Dawley; Substance P; Transcutaneous Electric Nerve Stimulation; Trigeminal Nerve | 2014 |
μ-Opioid receptor inhibition of substance P release from primary afferents disappears in neuropathic pain but not inflammatory pain.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ganglia, Spinal; Hyperalgesia; Inflammation; Male; Neurons; Pain; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Opioid, mu; Sciatic Nerve; Sciatica; Spinal Cord; Substance P | 2014 |
Increased neuronal expression of neurokinin-1 receptor and stimulus-evoked internalization of the receptor in the rostral ventromedial medulla of the rat after peripheral inflammatory injury.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Freund's Adjuvant; Glial Fibrillary Acidic Protein; Hyperalgesia; Inflammation; Male; Medulla Oblongata; Neurons; Peripheral Nerve Injuries; Phosphopyruvate Hydratase; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P | 2014 |
Sustained neurochemical plasticity in central terminals of mouse DRG neurons following colitis.
Topics: Animals; Colitis; Dextran Sulfate; Ganglia, Spinal; Inflammation; Intestines; Lumbosacral Region; Male; Mice; Neuronal Plasticity; Pain; Posterior Horn Cells; Substance P | 2014 |
In vivo regulation of NGF-mediated functions by Nedd4-2 ubiquitination of TrkA.
Topics: Animals; Calcitonin Gene-Related Peptide; Endosomal Sorting Complexes Required for Transport; Ganglia, Spinal; Hot Temperature; Inflammation; Mice; Mice, Transgenic; Mutation; Nedd4 Ubiquitin Protein Ligases; Nerve Growth Factor; Neurons; Pain; Protein Binding; Receptor, trkA; Substance P; Ubiquitin-Protein Ligases; Ubiquitination | 2014 |
Chemokine expression of CCL2, CCL3, CCL5 and CXCL10 during early inflammatory tendon healing precedes nerve regeneration: an immunohistochemical study in the rat.
Topics: Achilles Tendon; Animals; Biomarkers; Chemokine CCL2; Chemokine CCL3; Chemokine CCL5; Chemokine CXCL10; Chemokines; Immunohistochemistry; Inflammation; Male; Nerve Regeneration; Rats; Rats, Sprague-Dawley; Rupture; Substance P; Tendon Injuries; Ubiquitin Thiolesterase; Wound Healing | 2015 |
NK1 receptor blockade is ineffective in improving outcome following a balloon compression model of spinal cord injury.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Inflammation; Neurokinin-1 Receptor Antagonists; Protease Inhibitors; Rabbits; Receptors, Neurokinin-1; Spinal Cord Compression; Substance P; Tryptophan | 2014 |
Eosinophil-dependent skin innervation and itching following contact toxicant exposure in mice.
Topics: Allergens; Animals; Cell Degranulation; Collagen; Dinitrofluorobenzene; Disease Models, Animal; Eosinophilia; Eosinophils; Fibrosis; Inflammation; Mice; Phthalic Anhydrides; Pruritus; Skin; Substance P | 2015 |
Intra-articular (IA) ropivacaine microparticle suspensions reduce pain, inflammation, cytokine, and substance p levels significantly more than oral or IA celecoxib in a rat model of arthritis.
Topics: Administration, Oral; Amides; Animals; Arthritis, Experimental; Celecoxib; Cytokines; Inflammation; Injections, Intra-Articular; Male; Microspheres; Pain; Rats; Ropivacaine; Substance P | 2015 |
Variability in C-type lectin receptors regulates neuropathic pain-like behavior after peripheral nerve injury.
Topics: Animals; Cathepsins; Gene Expression Profiling; Gene Expression Regulation; Genetic Variation; Inflammation; Interleukin-1beta; Lectins, C-Type; Male; Models, Genetic; Multigene Family; Neuralgia; Neuropeptides; Peripheral Nerve Injuries; Phenotype; Rats; Receptors, Interleukin-8A; RNA, Messenger; Signal Transduction; Substance P | 2014 |
A dual delivery of substance P and bone morphogenetic protein-2 for mesenchymal stem cell recruitment and bone regeneration.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Regeneration; Cattle; Cell Differentiation; Cell Movement; Fibrin; Flow Cytometry; Heparin; Humans; Inflammation; Mesenchymal Stem Cells; Mice; Multipotent Stem Cells; Osteogenesis; Real-Time Polymerase Chain Reaction; Skull; Substance P; Tissue Scaffolds | 2015 |
Somatostatin negatively regulates parasite burden and granulomatous responses in cysticercosis.
Topics: Animals; Brain; Cestoda; Cysticercosis; Granuloma; Humans; Inflammation; Interferon-gamma; Interleukin-1beta; Mice; Mice, Knockout; Somatostatin; Substance P; Taenia solium | 2014 |
[Experimental study on the impact of photodynamic therapy on the tissue structure of normal nasal mucosa in rabbit].
Topics: Animals; Cilia; Inflammation; Nasal Mucosa; Neuropeptides; Photochemotherapy; Rabbits; Substance P | 2014 |
Differential Changes in the Peptidergic and the Non-Peptidergic Skin Innervation in Rat Models for Inflammation, Dry Skin Itch, and Dermatitis.
Topics: Acetone; Animals; Biopsy; Calcitonin Gene-Related Peptide; Dermatitis; Dinitrochlorobenzene; Disease Models, Animal; Freund's Adjuvant; Inflammation; Male; Nerve Fibers; Pruritus; Rats; Rats, Wistar; Receptors, Purinergic P2X3; Skin; Substance P | 2015 |
Substance P promotes wound healing in diabetes by modulating inflammation and macrophage phenotype.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Inflammation; Macrophages; Mice; Rabbits; Receptors, Neurokinin-1; Skin; Substance P; Wound Healing | 2015 |
[Changes of the innervation in the mucous membrane and glands of the tongue in early and late experimental diabetes mellitus].
Topics: Animals; Autonomic Fibers, Postganglionic; Diabetes Mellitus, Experimental; Inflammation; Lymphocytes; Male; Mast Cells; Mouth Mucosa; Neuropeptide Y; Neurotransmitter Agents; Plasma Cells; Rats; Rats, Wistar; Salivary Glands; Streptozocin; Substance P; Time Factors; Tongue | 2015 |
Substance P and Chronic Pain in Patients with Chronic Inflammation of Connective Tissue.
Topics: Arthritis, Rheumatoid; Chronic Pain; Connective Tissue; Female; Humans; Inflammation; Male; Middle Aged; Osteoarthritis; Substance P; Synovial Fluid; Synovial Membrane | 2015 |
Icariin inhibits TNF-α/IFN-γ induced inflammatory response via inhibition of the substance P and p38-MAPK signaling pathway in human keratinocytes.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cytokines; Dose-Response Relationship, Drug; Flavonoids; Humans; Inflammation; Interferon-gamma; Keratinocytes; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Receptors, Interferon; Receptors, Tumor Necrosis Factor; Signal Transduction; Substance P; Tumor Necrosis Factor-alpha | 2015 |
Sensory Neuropeptides and Endogenous Opioids Expression in Human Dental Pulp with Asymptomatic Inflammation: In Vivo Study.
Topics: Adolescent; Analgesics, Opioid; beta-Endorphin; Calcitonin Gene-Related Peptide; Child; Dental Pulp; Enkephalins; Female; Humans; Inflammation; Male; Methionine; Molar; Neuropeptides; Orthodontics; Pain; Pilot Projects; Radioimmunoassay; Substance P | 2015 |
Changes in the disposition of substance P in the rostral ventromedial medulla after inflammatory injury in the rat.
Topics: Actin Cytoskeleton; Animals; Disease Models, Animal; Freund's Adjuvant; Functional Laterality; Gene Expression Regulation; Hyperalgesia; Inflammation; Male; Medulla Oblongata; Mitogen-Activated Protein Kinase 6; Pain; Pain Measurement; Pain Threshold; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance P; Tachykinins | 2016 |
Substance P promotes diabetic wound healing by modulating inflammation and restoring cellular activity of mesenchymal stem cells.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Inflammation; Interleukin-10; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred ICR; Neovascularization, Physiologic; Neurotransmitter Agents; Substance P; Tumor Necrosis Factor-alpha; Wound Healing; Wounds and Injuries | 2016 |
Covalent immobilization of stem cell inducing/recruiting factor and heparin on cell-free small-diameter vascular graft for accelerated in situ tissue regeneration.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Blood Vessel Prosthesis; Cell Movement; Cell Shape; Cells, Immobilized; Endothelial Cells; Extracellular Matrix; Heparin; Humans; Implants, Experimental; Inflammation; Kinetics; Macrophages; Mesenchymal Stem Cells; Myocytes, Smooth Muscle; Neovascularization, Physiologic; Platelet Adhesiveness; Polyesters; Rats; Regeneration; Staining and Labeling; Substance P; Tissue Scaffolds | 2016 |
5-HT3 receptors promote colonic inflammation via activation of substance P/neurokinin-1 receptors in dextran sulphate sodium-induced murine colitis.
Topics: Animals; Benzimidazoles; Colitis; Colon; Dextran Sulfate; Dose-Response Relationship, Drug; Inflammation; Male; Mice; Mice, Inbred C57BL; Ondansetron; Receptors, Neurokinin-1; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Antagonists; Structure-Activity Relationship; Substance P | 2016 |
Efficacy of oral meloxicam suspension for prevention of pain and inflammation following band and surgical castration in calves.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Heart Rate; Hydrocortisone; Inflammation; Male; Meloxicam; Orchiectomy; Pain Measurement; Pain, Postoperative; Substance P; Thiazines; Thiazoles | 2016 |
Evidence for the existence of nociceptors in rat thoracolumbar fascia.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Fascia; Fasciitis; Inflammation; Male; Nociceptors; Rats; Rats, Sprague-Dawley; Substance P; TRPV Cation Channels | 2016 |
Substance-P alleviates dextran sulfate sodium-induced intestinal damage by suppressing inflammation through enrichment of M2 macrophages and regulatory T cells.
Topics: Animals; Dextran Sulfate; Inflammation; Inflammatory Bowel Diseases; Interleukin-17; Intestinal Mucosa; Intestines; Macrophages; Male; Mice; Substance P; Tumor Necrosis Factor-alpha | 2017 |
Acid-Sensing Ion Channel 1a Contributes to Airway Hyperreactivity in Mice.
Topics: Acid Sensing Ion Channels; Animals; Asthma; Bronchoalveolar Lavage Fluid; Inflammation; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Respiratory Hypersensitivity; Respiratory System; Sensory Receptor Cells; Substance P; Vagus Nerve | 2016 |
Substance P Induces HO-1 Expression in RAW 264.7 Cells Promoting Switch towards M2-Like Macrophages.
Topics: Animals; Gene Expression Regulation; Heme Oxygenase-1; Humans; Inflammation; Interleukin-10; Interleukin-6; Lipopolysaccharides; Macrophages; Membrane Proteins; Mice; Nitric Oxide; Nitric Oxide Synthase Type II; Periodontal Ligament; RAW 264.7 Cells; Substance P; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2016 |
The VGF-derived peptide TLQP-21: a new modulatory peptide for inflammatory pain.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Embryo, Mammalian; Ganglia, Spinal; Inflammation; Male; Mice; Nerve Growth Factors; Neurons; Neuropeptides; Pain; Pain Measurement; Pain Threshold; Peptide Fragments; Substance P | 2008 |
Pregabalin and gabapentin inhibit substance P-induced NF-kappaB activation in neuroblastoma and glioma cells.
Topics: Amines; Animals; Cell Line, Tumor; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Ganglia, Spinal; Glioma; Humans; Inflammation; Neuroblastoma; NF-kappa B; Pregabalin; Rats; Rats, Sprague-Dawley; Signal Transduction; Substance P | 2008 |
Gibberellic acid, a plant growth regulator, increases mast cell recruitment and alters Substance P levels.
Topics: Animals; Cell Count; Cell Degranulation; Gibberellins; Inflammation; Male; Mast Cells; Oxidative Stress; Plant Growth Regulators; Rats; Rats, Wistar; Skin; Substance P; Urinary Bladder | 2008 |
Substance P enhances wound closure in nitric oxide synthase knockout mice.
Topics: Animals; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase; Skin; Soft Tissue Injuries; Substance P; Time Factors; Wound Healing | 2009 |
Participation of peripheral tachykinin NK1 receptors in the carrageenan-induced inflammation of the rat temporomandibular joint.
Topics: Animals; Carrageenan; Data Interpretation, Statistical; Extravasation of Diagnostic and Therapeutic Materials; Inflammation; Interleukin-1beta; Leukocyte Count; Male; Neurokinin-1 Receptor Antagonists; Pain; Peroxidase; Piperidines; Quinuclidines; Radiopharmaceuticals; Rats; Rats, Wistar; Receptors, Neurokinin-1; Serum Albumin, Radio-Iodinated; Substance P; Temporomandibular Joint Disorders; Tumor Necrosis Factor-alpha | 2009 |
Role of protein kinase C and phosphoinositide 3-kinase-Akt in substance P-induced proinflammatory pathways in mouse macrophages.
Topics: Animals; Cell Line; Chemokines; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Inflammation; Kinetics; Macrophages, Peritoneal; Mice; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Isoforms; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Receptors, Neurokinin-1; Substance P | 2009 |
High force reaching task induces widespread inflammation, increased spinal cord neurochemicals and neuropathic pain.
Topics: Analysis of Variance; Animals; Bone and Bones; Cytokines; Disease Models, Animal; Ectodysplasins; Enzyme-Linked Immunosorbent Assay; Female; Inflammation; Macrophages; Movement; Musculoskeletal System; Neural Conduction; Neuralgia; Neurokinin A; Rats; Rats, Sprague-Dawley; Sensory Thresholds; Skin; Spinal Cord; Substance P; Time Factors; Upper Extremity | 2009 |
Protection from DNBS-induced colitis by the tachykinin NK(1) receptor antagonist SR140333 in rats.
Topics: Animals; Colitis; Dinitrofluorobenzene; Humans; Inflammation; Intestinal Mucosa; Intestines; Male; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Substrate Specificity; Tumor Necrosis Factor-alpha | 2009 |
Substance P expression in the distal cerebrospinal fluid-contacting neurons and spinal trigeminal nucleus in formalin-induced the orofacial inflammatory pain in rats.
Topics: Animals; Facial Pain; Formaldehyde; Immunohistochemistry; Inflammation; Injections, Subcutaneous; Male; Microscopy, Immunoelectron; Neurons; Pain Measurement; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Substance P; Trigeminal Nucleus, Spinal | 2009 |
Investigation of the inflammatory mechanisms in alopecia areata.
Topics: Adolescent; Adult; Aged; Alopecia Areata; Antigens, CD; Child; Female; Humans; Immunohistochemistry; Inflammation; Male; Mast Cells; Middle Aged; Receptors, Nerve Growth Factor; Stress, Psychological; Substance P | 2009 |
Tumor bearing decreases systemic acute inflammation in rats--role of mast cell degranulation.
Topics: Animals; Bradykinin; Capillary Permeability; Capsaicin; Carrageenan; Cell Degranulation; Dextrans; Edema; Histamine; Inflammation; Mast Cells; Neoplasm Transplantation; Neoplasms; Neutrophil Activation; Neutrophil Infiltration; p-Methoxy-N-methylphenethylamine; Rats; Rats, Wistar; Serotonin; Substance P | 2009 |
Expression of substance P and neurokinin-1-receptor in laryngeal cancer: linking chronic inflammation to cancer promotion and progression.
Topics: Carcinoma; Disease Progression; Humans; Immunohistochemistry; Inflammation; Kaplan-Meier Estimate; Laryngeal Neoplasms; Receptors, Neurokinin-1; Retrospective Studies; Substance P | 2009 |
Interleukin-1alpha regulates substance P expression and release in adult sensory neurons.
Topics: Age Factors; Animals; Capsaicin; Cells, Cultured; Female; Ganglia, Spinal; Inflammation; Interleukin 1 Receptor Antagonist Protein; Interleukin-1alpha; Interleukin-1beta; Nerve Growth Factor; Neuralgia; Nociceptors; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Sensory System Agents; Substance P; Up-Regulation | 2009 |
Common pathways for activation of proinflammatory gene expression by G protein-coupled receptors in primary lung epithelial and endothelial cells.
Topics: Animals; Chemokine CXCL1; Endothelial Cells; Epithelial Cells; Gene Expression Regulation; Humans; Inflammation; Interleukin-8; Lung; Male; Microvessels; Platelet Activating Factor; Rats; Receptors, G-Protein-Coupled; Signal Transduction; Substance P | 2009 |
Effect of genetic SSTR4 ablation on inflammatory peptide and receptor expression in the non-inflamed and inflamed murine intestine.
Topics: Animals; Calcitonin Gene-Related Peptide; Gastrointestinal Tract; Gene Expression Regulation; Immunohistochemistry; Inflammation; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Peptides; Receptors, Somatostatin; Reverse Transcriptase Polymerase Chain Reaction; Substance P | 2009 |
Post-junctional facilitation of Substance P signaling in a tibia fracture rat model of complex regional pain syndrome type I.
Topics: Animals; Calcitonin Gene-Related Peptide; Cell Proliferation; Disease Models, Animal; Edema; Foot; Ganglia, Spinal; Gene Expression Regulation; Hyperemia; Inflammation; Keratinocytes; Male; Neprilysin; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Reflex Sympathetic Dystrophy; RNA, Messenger; Sciatic Nerve; Sensory Receptor Cells; Signal Transduction; Skin Temperature; Substance P; Tibial Fractures | 2009 |
Substance P enhances excitatory synaptic transmission on spinally projecting neurons in the rostral ventromedial medulla after inflammatory injury.
Topics: Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Indoles; Inflammation; Male; Maleimides; Medulla Oblongata; Neural Pathways; Neurons; Neurotransmitter Agents; Pain; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Serotonin; Substance P; Sulfonamides; Synaptic Transmission | 2009 |
Intraluminal blockade of cell-surface CD74 and glucose regulated protein 78 prevents substance P-induced bladder inflammatory changes in the rat.
Topics: Animals; Antigens, Differentiation, B-Lymphocyte; Cell Membrane; Heat-Shock Proteins; Histocompatibility Antigens Class II; Inflammation; Male; Microscopy, Fluorescence; Models, Biological; Oligonucleotide Array Sequence Analysis; Protein Transport; Rats; Rats, Sprague-Dawley; Signal Transduction; Substance P; Urinary Bladder | 2009 |
Rat colitis induced by intrathecal injection of substance P.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Inflammation; Injections, Spinal; Intramolecular Oxidoreductases; Macrophage Migration-Inhibitory Factors; Male; Neurokinin-1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P | 2009 |
[The expression of substance P in airway mucosa of guinea pigs with repetitive esophageal stimulation by hydrochloric acid].
Topics: Animals; Esophagus; Gastroesophageal Reflux; Guinea Pigs; Hydrochloric Acid; Inflammation; Male; Respiratory Mucosa; Substance P | 2009 |
MicroRNAs may mediate the down-regulation of neurokinin-1 receptor in chronic bladder pain syndrome.
Topics: Adult; Aged; Base Sequence; Biopsy; Cells, Cultured; Cystitis, Interstitial; Databases, Nucleic Acid; Down-Regulation; Epithelium; Female; Gene Expression Profiling; Humans; Inflammation; Male; MicroRNAs; Middle Aged; Molecular Sequence Data; Myocytes, Smooth Muscle; Permeability; Receptors, Neurokinin-1; RNA, Messenger; Substance P; Syndrome; Urothelium; Young Adult | 2010 |
Anti-inflammatory evaluation of Coronopus didymus in the pleurisy and paw oedema models in mice.
Topics: Adenosine Deaminase; Animals; Anti-Inflammatory Agents; Bradykinin; Brazil; Carrageenan; Edema; Histamine; Inflammation; Leukocyte Count; Leukocytes; Mice; Neutrophils; Nitric Oxide; Peroxidase; Plant Leaves; Pleurisy; Rats; Substance P | 2010 |
Gene expression of pro-inflammatory cytokines and neuropeptides in diabetic wound healing.
Topics: Alloxan; Animals; Cytokines; Diabetes Mellitus, Experimental; Disease Models, Animal; Inflammation; Interleukin-6; Interleukin-8; Neuropeptide Y; Neuropeptides; Rabbits; Substance P; Wound Healing | 2011 |
Differences between orofacial inflammation and cancer pain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Carcinoma 256, Walker; Disease Models, Animal; Facial Neoplasms; Facial Pain; Galanin; Hot Temperature; Hyperalgesia; Indomethacin; Inflammation; Injections, Intraperitoneal; Male; Neuropeptides; Neurotransmitter Agents; Pain Threshold; Physical Stimulation; Rats; Rats, Wistar; Reaction Time; Substance P; Touch; Trigeminal Caudal Nucleus; Vibrissae | 2010 |
Substance P alters the in vitro LPS responsiveness of bovine monocytes and blood-derived macrophages.
Topics: Animals; Cattle; Cell Movement; Chemokine CCL5; Flow Cytometry; Inflammation; Interleukin-1beta; Interleukin-8; Lipopolysaccharides; Lymphocyte Subsets; Macrophages; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; RNA; Substance P | 2010 |
Histamine H3 receptor activation potentiates peripheral opioid-mediated antinociception: substance P role in peripheral inflammation in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Fentanyl; Freund's Adjuvant; Histamine Agonists; Hyperalgesia; Inflammation; Male; Methylhistamines; Mice; Naloxone; Pain; Piperidines; Receptors, Histamine H3; Skin; Substance P | 2010 |
Peripheral sensitization of sensory neurons.
Topics: Animals; Cells, Cultured; Female; Ganglia, Spinal; Immunohistochemistry; Inflammation; Microscopy, Video; Nociceptors; Pain; Rats; Rats, Long-Evans; Receptors, Neurokinin-1; Sensory Receptor Cells; Substance P | 2010 |
Subcutaneous injection of endokinin C/D attenuates carrageenan-induced inflammation.
Topics: Analgesics, Non-Narcotic; Animals; Carrageenan; Dose-Response Relationship, Drug; Edema; Hindlimb; Hot Temperature; Humans; Hyperalgesia; Inflammation; Injections, Subcutaneous; Male; Neuritis; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Peripheral Nervous System Agents; Quinuclidines; Rats; Rats, Sprague-Dawley; Reaction Time; Substance P; Tachykinins | 2010 |
Plasticity of hyperpolarization-activated and cyclic nucleotid-gated cation channel subunit 2 expression in the spinal dorsal horn in inflammatory pain.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Freund's Adjuvant; Functional Laterality; Gene Expression Regulation; Hyperalgesia; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Inflammation; Ion Channels; Male; Microscopy, Confocal; Pain; Pain Measurement; Posterior Horn Cells; Potassium Channels; Presynaptic Terminals; Rats; Rats, Inbred WKY; Spinal Cord; Substance P | 2010 |
Spinal cord mechanisms mediating behavioral hyperalgesia induced by neurokinin-1 tachykinin receptor activation in the rostral ventromedial medulla.
Topics: Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Freund's Adjuvant; GABA Agents; Hyperalgesia; In Vitro Techniques; Inflammation; Male; Medulla Oblongata; Membrane Potentials; Microinjections; Muscimol; Ondansetron; Oxazines; Pain Measurement; Pain Threshold; Posterior Horn Cells; Pyridazines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-1; Serotonin Antagonists; Spinal Cord; Substance P; Tryptophan; Up-Regulation | 2010 |
Delta opioid receptor-mediated analgesia is not altered in preprotachykinin A knockout mice.
Topics: Analgesia; Animals; Behavior, Animal; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; Neurons; Oligopeptides; Pain; Pain Measurement; Protein Precursors; Receptors, Opioid, delta; Substance P; Tachykinins | 2010 |
Substance P activates both contractile and inflammatory pathways in lymphatics through the neurokinin receptors NK1R and NK3R.
Topics: Animals; Cells, Cultured; Inflammation; Lymphatic Vessels; Male; Mitogen-Activated Protein Kinase 3; Muscle Contraction; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myosin Light Chains; Neurotransmitter Agents; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Signal Transduction; Substance P | 2011 |
Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia.
Topics: Androstadienes; Animals; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Formaldehyde; Gene Expression Regulation, Enzymologic; Hyperalgesia; Inflammation; Male; Nerve Tissue Proteins; Pain Measurement; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reaction Time; Signal Transduction; Sirolimus; Spinal Cord; Statistics, Nonparametric; Substance P; Time Factors; TOR Serine-Threonine Kinases; Wortmannin | 2011 |
Nerve growth factor induced expression of iNOS and substance P in dorsal root ganglion sensory neuron and interferon regulatory factor-1.
Topics: Animals; Cells, Cultured; Embryo, Mammalian; Female; Ganglia, Spinal; Inflammation; Interferon Regulatory Factor-1; Nerve Growth Factor; Nitric Oxide Synthase Type II; Pregnancy; Rats; Rats, Sprague-Dawley; Respiratory System; RNA, Messenger; Sensory Receptor Cells; Substance P; Transfection | 2011 |
Potential mechanisms for hypoalgesia induced by anti-nerve growth factor immunoglobulin are identified using autoimmune nerve growth factor deprivation.
Topics: Age Factors; Animals; Antibodies, Monoclonal, Humanized; Calcitonin Gene-Related Peptide; Cytochromes c; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Ganglia, Spinal; Glycoproteins; Immunoglobulins; Inflammation; Male; NAV1.8 Voltage-Gated Sodium Channel; Nerve Growth Factor; Nerve Tissue Proteins; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Sodium Channels; Substance P | 2011 |
Persistent epithelial barrier alterations in a rat model of postinfectious gut dysfunction.
Topics: Animals; Capsaicin; Chymases; Enteric Nervous System; Gastrointestinal Tract; Inflammation; Intestinal Mucosa; Ion Transport; Male; Mast Cells; Mastocytosis; Neurotransmitter Agents; Permeability; Rats; Rats, Sprague-Dawley; Sensory System Agents; Sodium Channel Blockers; Substance P; Tetrodotoxin; Trichinella spiralis; Trichinellosis | 2011 |
Hydrogen sulfide and neurogenic inflammation in polymicrobial sepsis: involvement of substance P and ERK-NF-κB signaling.
Topics: Animals; Capsaicin; Cell Nucleus; Chemokines; Cytokines; Extracellular Signal-Regulated MAP Kinases; Hydrogen Sulfide; Inflammation; Male; Mice; NF-kappa B; Phosphorylation; Sepsis; Substance P; TRPV Cation Channels | 2011 |
Peripheral inflammation alters desensitization of substance P-evoked current in rat dorsal root ganglion neurons.
Topics: Animals; Evoked Potentials; Ganglia, Spinal; Inflammation; Male; Neurons; Peripheral Nervous System; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P | 2011 |
Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study.
Topics: Animals; Brain-Derived Neurotrophic Factor; Calcitonin Gene-Related Peptide; Cells, Cultured; Ganglia, Spinal; Hyperalgesia; Inflammation; Male; MAP Kinase Signaling System; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptor, trkB; Sensory Receptor Cells; Substance P; TRPV Cation Channels; Tumor Necrosis Factor-alpha; Up-Regulation | 2011 |
Knockdown of the tachykinin neurokinin 1 receptor by intrathecal administration of small interfering RNA in rats.
Topics: Animals; Base Sequence; Behavior, Animal; Carrageenan; Formaldehyde; Gene Expression Regulation; Gene Knockdown Techniques; Genetic Vectors; Hyperalgesia; Inflammation; Injections, Spinal; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; RNA, Small Interfering; Sendai virus; Spinal Cord; Substance P | 2011 |
Suppressive effects of glycyrrhetinic acid derivatives on tachykinin receptor activation and hyperalgesia.
Topics: Analgesics; Animals; Calcium; Capsaicin; CHO Cells; Cricetinae; Disease Models, Animal; Formaldehyde; Glycyrrhetinic Acid; Hot Temperature; Humans; Hyperalgesia; Inflammation; Ligation; Male; Neuralgia; Neurokinin A; Neurokinin B; Pain; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Sciatic Nerve; Substance P | 2011 |
VEGF signaling mediates bladder neuroplasticity and inflammation in response to BCG.
Topics: Animals; Antibodies, Neutralizing; BCG Vaccine; Calcitonin; Female; Inflammation; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Neuropilin-1; Neuropilin-2; Neuropilins; Protein Precursors; Recombinant Proteins; Semaphorins; Signal Transduction; Substance P; TRPV Cation Channels; Ubiquitin Thiolesterase; Urinary Bladder; Urothelium; Vascular Endothelial Growth Factor A | 2011 |
Influence of influenza A infection on capsaicin-induced responses in murine airways.
Topics: Animals; Biphenyl Compounds; Bronchoalveolar Lavage Fluid; Capsaicin; Carbachol; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Inflammation; Influenza A virus; Isoproterenol; Leukocytes; Male; Mice; Mice, Inbred BALB C; Models, Biological; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Orthomyxoviridae Infections; Piperidines; Prostaglandin Antagonists; Respiratory Mucosa; Specific Pathogen-Free Organisms; Substance P; Trachea; TRPV Cation Channels; Xanthones | 2012 |
Pharmacological characteristics of endokinin C/D-derived peptides in nociceptive and inflammatory processing in rats.
Topics: Amino Acid Sequence; Amino Acids; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Formaldehyde; Humans; Hyperalgesia; Immunohistochemistry; Inflammation; Injections, Subcutaneous; Male; Nociceptive Pain; Pain Measurement; Peptide Fragments; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Substance P; Tachykinins; Time Factors; Tryptophan | 2011 |
The proximodistal aggravation of colitis depends on substance P released from TRPV1-expressing sensory neurons.
Topics: Animals; Calcitonin Gene-Related Peptide; Colitis; Dextran Sulfate; Disease Models, Animal; Gene Expression Regulation; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; Sensory Receptor Cells; Severity of Illness Index; Substance P; TRPV Cation Channels | 2012 |
Mapping biological to clinical phenotypes during the development (21 days) and resolution (21 days) of experimental gingivitis.
Topics: Adolescent; Adult; Biomarkers; Cathepsin G; Dental Plaque; Female; Gingival Crevicular Fluid; Gingivitis; Humans; Inflammation; Interleukin-1beta; Leukocyte Elastase; Male; Middle Aged; Oral Hygiene; Reference Values; Single-Blind Method; Substance P; Young Adult | 2012 |
Activation of transient receptor potential ankyrin 1 evokes nociception through substance P release from primary sensory neurons.
Topics: Acetanilides; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Ganglia, Spinal; Inflammation; Isothiocyanates; Male; Nociception; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Transport; Purines; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Neurokinin-1; Sensory Receptor Cells; Signal Transduction; Substance P; TRPA1 Cation Channel; TRPC Cation Channels | 2012 |
Dragon's blood inhibits chronic inflammatory and neuropathic pain responses by blocking the synthesis and release of substance P in rats.
Topics: Analgesics, Non-Narcotic; Animals; Bradykinin; Capsaicin; Carrageenan; Chalcone; Cyclooxygenase 2; Drugs, Chinese Herbal; Ganglia, Spinal; Inflammation; Male; Pain; Plant Extracts; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Sciatic Nerve; Substance P; Tachykinins | 2012 |
Treatment with a substance P receptor antagonist is neuroprotective in the intrastriatal 6-hydroxydopamine model of early Parkinson's disease.
Topics: Animals; Anti-Inflammatory Agents; Blood-Brain Barrier; Cells; Dopaminergic Neurons; Inflammation; Male; Motor Activity; Neurokinin-1 Receptor Antagonists; Neuroprotective Agents; Oxidopamine; Parkinson Disease, Secondary; Piperidines; Rats; Rats, Sprague-Dawley; Rotarod Performance Test; Substance P; Substantia Nigra; Tryptophan | 2012 |
Regulation of peripheral clock to oscillation of substance P contributes to circadian inflammatory pain.
Topics: Animals; ARNTL Transcription Factors; Circadian Rhythm; CLOCK Proteins; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; Pain; Receptors, Neurokinin-1; Substance P; Suprachiasmatic Nucleus | 2012 |
Targeting classical but not neurogenic inflammation reduces peritumoral oedema in secondary brain tumours.
Topics: Animals; Anti-Inflammatory Agents; Blood-Brain Barrier; Brain Edema; Brain Neoplasms; Dexamethasone; Disease Models, Animal; Inflammation; Male; Neurokinin-1 Receptor Antagonists; Rats; Rats, Wistar; Substance P | 2012 |
Substance P induces M2-type macrophages after spinal cord injury.
Topics: Animals; Anti-Inflammatory Agents; Axons; Cytokines; Inflammation; Interleukin-10; Macrophages; Male; Microglia; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord Injuries; Substance P; Tumor Necrosis Factor-alpha | 2012 |
Anti-inflammatory and anti-ulcer activities of carvacrol, a monoterpene present in the essential oil of oregano.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Arachidonic Acid; Cymenes; Edema; Female; Indomethacin; Inflammation; Male; Mice; Monoterpenes; Oils, Volatile; Origanum; Rats; Rats, Wistar; Ruthenium Red; Stomach Ulcer; Substance P; Tetradecanoylphorbol Acetate | 2012 |
Sensation of abdominal pain induced by peritoneal carcinomatosis is accompanied by changes in the expression of substance P and μ-opioid receptors in the spinal cord of mice.
Topics: Abdominal Pain; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Carcinoma; Cell Line; Cell Line, Tumor; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Immunohistochemistry; Inflammation; Luciferases; Mice; Mice, Inbred ICR; Mice, SCID; Neoplasm Transplantation; Pancreatitis; Proto-Oncogene Proteins c-fos; Real-Time Polymerase Chain Reaction; Receptors, Opioid, mu; Spinal Cord; Substance P | 2012 |
Changes in microvascular reactivity after cardiopulmonary bypass in patients with poorly controlled versus controlled diabetes.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Aged; Arterioles; Cardiopulmonary Bypass; Coronary Artery Bypass; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Type 2; Disease Susceptibility; Endothelium, Vascular; Enzyme Induction; Female; Gene Expression Regulation; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Inflammation; Male; Microcirculation; Middle Aged; Muscle, Skeletal; Nitroprusside; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Substance P; Tyrosine; Vasoconstriction; Vasodilator Agents | 2012 |
Neuropeptides control the dynamic behavior of airway mucosal dendritic cells.
Topics: Animals; Asthma; Bone Marrow Cells; Bronchi; CD11c Antigen; Dendritic Cells; Hypersensitivity; Immune System; Inflammation; Lung; Mice; Mice, Transgenic; Microscopy; Microscopy, Confocal; Mucous Membrane; Neurons; Neuropeptides; Phagocytosis; Substance P | 2012 |
Peripheral substance P and neurokinin-1 receptors have a role in inflammatory and neuropathic orofacial pain models.
Topics: Animals; Behavior, Animal; Cold Temperature; Constriction, Pathologic; Facial Pain; Grooming; Hot Temperature; Hyperalgesia; Inflammation; Injections; Lip; Male; Neuralgia; Neurokinin-1 Receptor Antagonists; Pain Measurement; Physical Stimulation; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P; Tropanes | 2013 |
Loss of substance P and inflammation precede delayed neurodegeneration in the substantia nigra after cerebral ischemia.
Topics: Animals; Brain Ischemia; Cell Death; Coloring Agents; Dopaminergic Neurons; Immunohistochemistry; Infarction, Middle Cerebral Artery; Inflammation; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neostriatum; Neurodegenerative Diseases; Receptors, Neurokinin-1; Substance P; Substantia Nigra | 2013 |
Melatonin improves bladder symptoms and may ameliorate bladder damage via increasing HO-1 in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cell Proliferation; Cystitis, Interstitial; Female; Heme Oxygenase-1; Inflammation; Mast Cells; Melatonin; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Wistar; Substance P; Urinary Bladder | 2013 |
Upregulation of neurokinin-1 receptor expression in rat spinal cord by an N-terminal metabolite of substance P.
Topics: Afferent Pathways; Animals; Capsaicin; Dose-Response Relationship, Drug; Ganglia, Spinal; Immunohistochemistry; Inflammation; Isomerism; Male; Pain; Peptide Fragments; Posterior Horn Cells; Presynaptic Terminals; Protein Precursors; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; RNA, Messenger; Substance P; Tachykinins; Up-Regulation | 2002 |
Pan-neurotrophin receptor p75 contributes to neuronal hyperreactivity and airway inflammation in a murine model of experimental asthma.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Immunohistochemistry; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Growth Factors; Neurons; Ovalbumin; Receptor, Nerve Growth Factor; Receptors, Nerve Growth Factor; Respiratory System; Substance P | 2003 |
Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammatory events via neuropeptide substance P-dependent pathways.
Topics: Acoustic Stimulation; Animals; Apoptosis; Cell Cycle; Female; Hair; Hair Follicle; In Situ Nick-End Labeling; Inflammation; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Stress, Psychological; Substance P | 2003 |
Bone marrow transplantation reveals an essential synergy between neuronal and hemopoietic cell neurokinin production in pulmonary inflammation.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Capsaicin; Enzyme-Linked Immunosorbent Assay; Gene Deletion; Gene Expression Regulation; Hematopoietic Stem Cells; Immune System; Inflammation; Ligands; Lung; Mice; Mice, Transgenic; Neurokinin A; Neurons; Protein Precursors; Respiration; Substance P; Tachykinins; Time Factors; Trachea | 2003 |
Asphalt exposure enhances neuropeptide levels in sensory neurons projecting to the rat nasal epithelium.
Topics: Animals; Calcitonin Gene-Related Peptide; Epithelium; Female; Hydrocarbons; Immunohistochemistry; Inflammation; Inhalation Exposure; Microspheres; Nasal Mucosa; Neurons; Rats; Rats, Sprague-Dawley; Rhodamines; Substance P; Therapeutic Irrigation | 2003 |
A study of the cough reflex in idiopathic pulmonary fibrosis.
Topics: Aged; Anti-Inflammatory Agents; Bradykinin; Brain-Derived Neurotrophic Factor; Bronchial Provocation Tests; Capsaicin; Case-Control Studies; Cough; Female; Forced Expiratory Volume; Humans; Inflammation; Leukocyte Count; Male; Nerve Growth Factor; Neutrophils; Prednisolone; Pulmonary Fibrosis; Sputum; Substance P; Total Lung Capacity; Treatment Outcome | 2003 |
Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Formaldehyde; Hyperalgesia; Imidazoles; Inflammation; Injections, Spinal; Isoenzymes; Male; Microglia; Mitogen-Activated Protein Kinases; Neuralgia; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pain Threshold; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 2003 |
Spinal upregulation of the nitric oxide synthase-interacting protein NOSIP in a rat model of inflammatory pain.
Topics: Animals; Carrier Proteins; Disease Models, Animal; Freund's Adjuvant; Functional Laterality; Ganglia, Spinal; Hindlimb; Immunohistochemistry; Inflammation; Injections; Lectins; Male; Pain; Pain Measurement; Phosphopyruvate Hydratase; Rats; Rats, Wistar; Spinal Cord; Substance P; Time Factors; Ubiquitin-Protein Ligases; Up-Regulation | 2003 |
Pregabalin and gabapentin reduce release of substance P and CGRP from rat spinal tissues only after inflammation or activation of protein kinase C.
Topics: Acetates; Amines; Analgesics; Animals; Calcitonin Gene-Related Peptide; Cyclohexanecarboxylic Acids; Enzyme Activation; Foot; Freund's Adjuvant; Gabapentin; gamma-Aminobutyric Acid; In Vitro Techniques; Inflammation; Male; Phorbol 12,13-Dibutyrate; Pregabalin; Protein Kinase C; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 2003 |
Stimulation of spinal 5-HT(2A/2C) receptors potentiates the capsaicin-induced in vivo release of substance P-like immunoreactivity in the rat dorsal horn.
Topics: Animals; Capsaicin; Carrageenan; Inflammation; Male; Microdialysis; Posterior Horn Cells; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin Receptor Agonists; Spinal Cord; Substance P | 2003 |
Intraplantar injection of a cyclooxygenase inhibitor ketorolac reduces immunoreactivities of substance P, calcitonin gene-related peptide, and dynorphin in the dorsal horn of rats with nerve injury or inflammation.
Topics: Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Carrageenan; Cell Count; Cyclooxygenase Inhibitors; Drug Interactions; Dynorphins; Functional Laterality; Hyperalgesia; Immunohistochemistry; Inflammation; Injections, Spinal; Ketorolac; Male; Pain Measurement; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Time Factors | 2003 |
Neuropeptides (SP and CGRP) augment pro-inflammatory cytokine production in HSV-infected macrophages.
Topics: Animals; Calcitonin Gene-Related Peptide; Chlorocebus aethiops; Cytokines; Drug Combinations; Herpesvirus 1, Human; Inflammation; Interleukin-1; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Substance P; Tumor Necrosis Factor-alpha; Vero Cells | 2003 |
Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I.
Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Formaldehyde; Hot Temperature; Hyperalgesia; Inflammation; Mice; Mice, Knockout; Neurons; Pain; Reaction Time; Substance P; Thionucleotides | 2004 |
Neuromodulation of experimental Shigella infection reduces damage to the gut mucosa.
Topics: Animals; Calcitonin Gene-Related Peptide; Dysentery, Bacillary; Galanin; Hexamethonium; Inflammation; Intestinal Mucosa; Intestine, Small; Motilin; Neuropeptides; Neurotensin; Nicotinic Antagonists; Peptide YY; Rabbits; Shigella flexneri; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 2004 |
Substance P can stimulate prostaglandin D2 and leukotriene C4 generation without granule exocytosis in murine mast cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Cells; Cross-Linking Reagents; Cyclooxygenase Inhibitors; Cytoplasmic Granules; Enzyme Inhibitors; Exocytosis; Genistein; Immunoglobulin E; Indoles; Indomethacin; Inflammation; Leukotriene C4; Lipids; Maleimides; Masoprocol; Mast Cells; Mice; Mice, Inbred BALB C; Prostaglandin D2; Signal Transduction; Stimulation, Chemical; Substance P | 2004 |
Cutting edge: hemokinin has substance P-like function and expression in inflammation.
Topics: Animals; Cell Line; Inflammation; Interferon-gamma; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Protein Precursors; Receptors, Neurokinin-1; Substance P; Tachykinins | 2004 |
Corticotropin-releasing hormone (CRH) requirement in Clostridium difficile toxin A-mediated intestinal inflammation.
Topics: Animals; Bacterial Toxins; Clostridioides difficile; Corticotropin-Releasing Hormone; Diarrhea; Enterotoxins; Ileum; In Vitro Techniques; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Fibers; Peroxidase; Substance P | 2004 |
Involvement of the neuropeptide substance P in lung inflammation induced by hepatic ischemia/reperfusion.
Topics: Animals; Bronchoalveolar Lavage Fluid; Chemokine CXCL2; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Inflammation; Liver; Lung; Male; Mice; Mice, Inbred C57BL; Monokines; Neuropeptides; Neutrophils; NF-kappa B; Peroxidase; Reperfusion Injury; Substance P; Time Factors | 2004 |
N-methyl-D-aspartate receptor blockade inhibits cardiac inflammation in the Mg2+-deficient rat.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fluorescent Antibody Technique; Heart Diseases; Inflammation; Intercellular Adhesion Molecule-1; Magnesium Deficiency; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stress, Physiological; Substance P | 2004 |
Pro-nociceptive role of peripheral galanin in inflammatory pain.
Topics: Action Potentials; Animals; Axons; Behavior, Animal; Capsaicin; Cell Count; Dose-Response Relationship, Drug; Drug Interactions; Galanin; Immunohistochemistry; In Vitro Techniques; Inflammation; Male; Microscopy, Electron; Pain; Pain Measurement; Peptide Fragments; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Receptor, Galanin, Type 2; Receptors, Drug; Skin; Substance P | 2004 |
Alteration of airway neuropeptide expression and development of airway hyperresponsiveness following respiratory syncytial virus infection.
Topics: Animals; Antiemetics; Calcitonin Gene-Related Peptide; Humans; Inflammation; Lung; Mice; Mice, Inbred BALB C; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Pyrrolidonecarboxylic Acid; Respiratory Hypersensitivity; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus, Human; Substance P | 2005 |
IL-12 induction of mRNA encoding substance P in murine macrophages from the spleen and sites of inflammation.
Topics: Animals; DNA-Binding Proteins; Gene Expression Regulation; Granuloma; Inflammation; Interleukin-12; Macrophages; Mice; Mice, Inbred Strains; Mice, Knockout; RNA, Messenger; Schistosomiasis; Spleen; STAT4 Transcription Factor; Substance P; Trans-Activators | 2005 |
Gastric perception thresholds are low and sensory neuropeptide levels high in helicobacter pylori-positive functional dyspepsia.
Topics: Adolescent; Adult; Calcitonin Gene-Related Peptide; Case-Control Studies; Dyspepsia; Female; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; Humans; Inflammation; Male; Middle Aged; Pain Measurement; Perception; Stomach; Substance P | 2005 |
Effects of pertussis toxin on electroacupuncture-produced anti-hyperalgesia in inflamed rats.
Topics: Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Electroacupuncture; Freund's Adjuvant; Hyperalgesia; Immunohistochemistry; Inflammation; Injections, Spinal; Lectins; Male; Pain Measurement; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Reaction Time; Substance P | 2005 |
Spinal phospholipase A2 in inflammatory hyperalgesia: role of the small, secretory phospholipase A2.
Topics: Animals; Blotting, Western; Carrageenan; Dialysis; Dinoprostone; Dose-Response Relationship, Drug; Functional Laterality; Gene Expression Regulation, Enzymologic; Group II Phospholipases A2; Hyperalgesia; Indoles; Inflammation; Inhibition, Psychological; Male; Pain Measurement; Phospholipases A; Phospholipases A2; Rats; Rats, Sprague-Dawley; Reaction Time; Spinal Cord; Substance P; Time Factors | 2005 |
Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammation.
Topics: Analysis of Variance; Animals; Blotting, Western; Electroacupuncture; Freund's Adjuvant; Hindlimb; Hyperalgesia; Immunohistochemistry; Inflammation; Lectins; Male; N-Glycosyl Hydrolases; Neurons; Opioid Peptides; Pain Measurement; Random Allocation; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, mu; Recombinant Fusion Proteins; Ribosome Inactivating Proteins, Type 1; Saporins; Skin; Spinal Cord; Substance P | 2005 |
Thoracic vagal efferent nerve stimulation evokes substance P-induced early airway bronchonstriction and late proinflammatory and oxidative injury in the rat respiratory tract.
Topics: Animals; Antioxidants; Blood Vessels; Bronchoconstriction; Carbon; Electric Stimulation Therapy; Electromyography; Endothelium, Vascular; Immunoblotting; Inflammation; Intercellular Adhesion Molecule-1; Luminol; Male; Myocytes, Smooth Muscle; Neurons, Efferent; NF-kappa B; Oxidative Stress; Oxygen; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Respiratory System; Silver Staining; Substance P; Tachykinins; Up-Regulation; Vagus Nerve | 2005 |
Dendritic cells do not transduce inflammatory stimuli via the capsaicin receptor TRPV1.
Topics: Animals; Bone Marrow Cells; Calcium; Capsaicin; Cells, Cultured; Dendritic Cells; Humans; Inflammation; Ion Channels; Mice; Mice, Inbred C57BL; Patch-Clamp Techniques; Rats; Signal Transduction; Substance P; TRPV Cation Channels | 2005 |
Pivotal role of endogenous tachykinins and the NK1 receptor in mediating leukocyte accumulation, in the absence of oedema formation, in response to TNFalpha in the cutaneous microvasculature.
Topics: Albumins; Analysis of Variance; Animals; Capsaicin; Dose-Response Relationship, Drug; Female; Glycoproteins; Immunohistochemistry; Inflammation; Injections, Intradermal; Iodine Isotopes; Leukocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Peroxidase; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Skin; Substance P; Tachykinins; Time Factors; Tumor Necrosis Factor-alpha | 2006 |
The progesterone derivative dydrogesterone down-regulates neurokinin 1 receptor expression on lymphocytes, induces a Th2 skew and exerts hypoalgesic effects in mice.
Topics: Animals; Cells, Cultured; Cytokines; Down-Regulation; Dydrogesterone; Female; Inflammation; Lymphocytes; Mast Cells; Mice; Mice, Inbred CBA; Neurotransmitter Agents; Pain Threshold; Receptors, Neurokinin-1; Substance P; Th2 Cells; Uterus | 2006 |
No response of plasma substance P, but delayed increase of interleukin-1 receptor antagonist to acute psychosocial stress.
Topics: Acute Disease; Adult; Affect; alpha-Amylases; Area Under Curve; Biomarkers; Endocrine Glands; Epinephrine; Humans; Hydrocortisone; Inflammation; Interleukin 1 Receptor Antagonist Protein; Male; Norepinephrine; Saliva; Sialoglycoproteins; Social Environment; Stress, Psychological; Substance P | 2006 |
Modulation of peripheral inflammation by the substance P N-terminal metabolite substance P1-7.
Topics: Animals; Central Nervous System; Dose-Response Relationship, Drug; Inflammation; Male; Naloxone; Neurons; Peptides; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Substance P; Vasodilator Agents | 2006 |
[The significance and effect of substance P on the expression of RANTES mRNA in allergic rhinitis].
Topics: Animals; Chemokine CCL5; Eosinophils; Female; Guinea Pigs; Inflammation; Male; Nasal Mucosa; Rhinitis, Allergic, Perennial; RNA, Messenger; Substance P | 2006 |
Neurogenic factors in the impaired healing of diabetic foot ulcers.
Topics: Aged; Calcitonin Gene-Related Peptide; Diabetes Mellitus, Type 2; Diabetic Foot; Epidermis; Female; GAP-43 Protein; Humans; Immunohistochemistry; Inflammation; Male; Middle Aged; Nerve Endings; Neurotrophin 3; Skin; Substance P; Ubiquitin Thiolesterase | 2006 |
Alterations in intestinal contractility during inflammation are caused by both smooth muscle damage and specific receptor-mediated mechanisms.
Topics: Acetylcholine; Animals; Electric Stimulation; Gastrointestinal Motility; In Vitro Techniques; Inflammation; Intestine, Small; Male; Muscle Contraction; Muscle, Smooth; Neurotransmitter Agents; Potassium Chloride; Rats; Rats, Sprague-Dawley; Substance P; Trichinella spiralis; Trichinellosis | 2006 |
Upregulation of substance P receptor expression by calcitonin gene-related peptide, a possible cooperative action of two neuropeptides involved in airway inflammation.
Topics: Animals; Asthma; Blotting, Western; Bronchial Hyperreactivity; Calcitonin Gene-Related Peptide; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Guinea Pigs; Humans; Inflammation; Lung; Ozone; Protein-Tyrosine Kinases; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Substance P; Up-Regulation | 2007 |
STAT-6-mediated control of P-selectin by substance P and interleukin-4 in human dermal endothelial cells.
Topics: Base Sequence; Binding Sites; Cells, Cultured; Consensus Sequence; Dermis; Endothelial Cells; Flow Cytometry; Humans; Inflammation; Interleukin-4; Molecular Sequence Data; P-Selectin; Receptors, Interleukin-4; Regulatory Sequences, Nucleic Acid; Skin Diseases; STAT6 Transcription Factor; Substance P; Transfection; Tumor Necrosis Factor-alpha | 2006 |
Effects of the neuropeptides substance P, calcitonin gene-related peptide, vasoactive intestinal polypeptide and galanin on the production of nerve growth factor and inflammatory cytokines in cultured human keratinocytes.
Topics: Calcitonin Gene-Related Peptide; Cells, Cultured; Cytokines; Female; Galanin; Humans; Inflammation; Keratinocytes; Nerve Growth Factor; Protein Precursors; RNA, Messenger; Substance P; Vasoactive Intestinal Peptide | 2006 |
Suppression of autoimmune encephalomyelitis by a neurokinin-1 receptor antagonist--a putative role for substance P in CNS inflammation.
Topics: Adoptive Transfer; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Blood-Brain Barrier; Central Nervous System; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Immunohistochemistry; Inflammation; Intercellular Adhesion Molecule-1; Mice; Neurokinin-1 Receptor Antagonists; Substance P; T-Lymphocytes; Vascular Cell Adhesion Molecule-1 | 2006 |
The inhibitory effects of local anesthetics on primary sensory nerve and parasympathetic nerve in rabbit eye.
Topics: Anesthetics, Local; Animals; Atropine; Autonomic Pathways; Carbachol; Cholinergic Fibers; Cocaine; Inflammation; Iris; Lidocaine; Male; Neurokinin A; Optic Nerve; Parasympathetic Nervous System; Rabbits; Substance P | 2006 |
Evidence of anti-inflammatory effects of Passiflora edulis in an inflammation model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Carrageenan; Disease Models, Animal; Female; Histamine; Inflammation; Interleukin-1beta; Leukocytes; Male; Mice; Nitric Oxide; Passiflora; Peroxidase; Phytotherapy; Plant Extracts; Pleurisy; Substance P; Tumor Necrosis Factor-alpha | 2007 |
The effect of substance P on nitric oxide release in a rheumatoid arthritis model.
Topics: Aged; Animals; Arthritis, Rheumatoid; Cells, Cultured; Disease Models, Animal; Female; Gene Expression Regulation; Humans; Inflammation; Interleukin-1beta; Mice; Mice, Knockout; Middle Aged; Neurotransmitter Agents; Nitrates; Nitric Oxide; Nitrites; Receptors, Neurokinin-1; Substance P; Synovial Membrane; Tumor Necrosis Factor-alpha | 2006 |
Cyclo-oxygenase-2-immunoreactive neurons in the lumbar dorsal horn in a chicken acute inflammation model.
Topics: Animals; Calcitonin Gene-Related Peptide; Chickens; Cyclooxygenase 2; Fluorescent Antibody Technique; Inflammation; Microscopy, Electron; Microtubule-Associated Proteins; Nerve Fibers; Posterior Horn Cells; Presynaptic Terminals; Substance P | 2006 |
Effect of long-term exposure to low-level toluene on airway inflammatory response in mice.
Topics: Administration, Inhalation; Animals; Bronchi; Bronchoalveolar Lavage Fluid; Chemokines; Cytokines; Female; Inflammation; Lung; Mice; Mice, Inbred C3H; Nerve Growth Factors; Neurotrophin 3; Pneumonia; Solvents; Substance P; Toluene | 2007 |
TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes.
Topics: Animals; Autoimmunity; Capsaicin; Diabetes Mellitus, Type 1; Female; Inflammation; Insulin Resistance; Insulin-Secreting Cells; Islets of Langerhans; Male; Mice; Mice, Congenic; Mice, Inbred C57BL; Mice, Inbred NOD; Neurons, Afferent; Substance P; T-Lymphocytes; TRPV Cation Channels | 2006 |
Upregulation of the axonal growth and the expression of substance P and its NK1 receptor in human allergic contact dermatitis.
Topics: Axons; Calcitonin Gene-Related Peptide; Dermatitis, Allergic Contact; GAP-43 Protein; Humans; Immunohistochemistry; Inflammation; Microscopy, Fluorescence; Receptors, Neurokinin-1; Skin; Skin Tests; Substance P; Tryptases; Ubiquitin Thiolesterase; Up-Regulation | 2006 |
Role of capsaicin-sensitive afferents and sensory neuropeptides in endotoxin-induced airway inflammation and consequent bronchial hyperreactivity in the mouse.
Topics: Animals; Bronchial Hyperreactivity; Calcitonin Gene-Related Peptide; Capsaicin; Endotoxins; Enzyme-Linked Immunosorbent Assay; Female; Histocytochemistry; Inflammation; Interleukin-1beta; Lung; Mice; Mice, Inbred C57BL; Neurons, Afferent; Neuropeptides; Peroxidase; Radioimmunoassay; Somatostatin; Spectrophotometry; Substance P | 2007 |
Neuropeptide substance P upregulates chemokine and chemokine receptor expression in primary mouse neutrophils.
Topics: Active Transport, Cell Nucleus; Animals; Biphenyl Compounds; CD11b Antigen; Cells, Cultured; Chemokine CCL3; Chemokine CCL4; Chemokine CXCL2; Chemokines; Chemokines, CC; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; I-kappa B Proteins; Inflammation; Macrophage Inflammatory Proteins; Male; Mice; Neuroimmunomodulation; Neutrophils; Nitriles; Receptors, CCR1; Receptors, Chemokine; Receptors, Interleukin-8B; Receptors, Neurokinin-1; Recombinant Proteins; RNA, Messenger; Signal Transduction; Substance P; Sulfones; Transcription Factor RelA; Up-Regulation | 2007 |
Administration of substance P during a primary immune response amplifies the secondary immune response via a long-lasting effect on CD8+ T lymphocytes.
Topics: Animals; CD8-Positive T-Lymphocytes; Dinitrofluorobenzene; Female; Inflammation; Mice; Mice, Inbred BALB C; Substance P | 2007 |
Effects of the bisphosphonate ibandronate on hyperalgesia, substance P, and cytokine levels in a rat model of persistent inflammatory pain.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Cytokines; Dinoprostone; Diphosphonates; Drug Evaluation, Preclinical; Edema; Foot; Freund's Adjuvant; Ganglia, Spinal; Hyperalgesia; Ibandronic Acid; Inflammation; Interleukin-1beta; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance P; Tumor Necrosis Factor-alpha | 2008 |
Anti-inflammatory evaluation of Solidago chilensis Meyen in a murine model of pleurisy.
Topics: Adenosine Deaminase; Animals; Anti-Inflammatory Agents; Bradykinin; Butanols; Carrageenan; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Flowers; Histamine; Inflammation; Interleukin-1beta; Leukocytes, Mononuclear; Male; Mice; Neutrophils; Peroxidase; Plant Extracts; Plant Leaves; Pleurisy; Rhizome; Solidago; Substance P; Tumor Necrosis Factor-alpha | 2007 |
Adverse effects of incretin therapy for type 2 diabetes.
Topics: Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Inflammation; Nasopharyngitis; Substance P | 2007 |
Targeted disruption of the galanin gene attenuates inflammatory responses in murine skin.
Topics: Animals; Antipruritics; Calcitonin Gene-Related Peptide; Capsaicin; Carrageenan; Galanin; Gene Targeting; Hot Temperature; Humans; Inflammation; Mice; Mice, Knockout; Neurotransmitter Agents; Neutrophils; Skin; Substance P | 2008 |
Substance P is involved in the cutaneous blood flow increase response to sympathetic nerve stimulation in persistently inflamed rats.
Topics: Adrenergic Fibers; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Electric Stimulation; Immunohistochemistry; Inflammation; Male; Neurokinin-1 Receptor Antagonists; Rats; Rats, Inbred Lew; Receptors, Neurokinin-1; Regional Blood Flow; Skin; Substance P; Sympathetic Nervous System; Time Factors; Vasodilation | 2007 |
Statins decrease expression of the proinflammatory neuropeptides calcitonin gene-related peptide and substance P in sensory neurons.
Topics: Animals; Calcitonin Gene-Related Peptide; Cells, Cultured; Gene Expression Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Inflammation Mediators; Male; Neurons, Afferent; Neuropeptides; Rats; Rats, Sprague-Dawley; Substance P | 2008 |
[Clinical significance of the functional and structural changes in the intestines in chronic cholecystitis].
Topics: Adult; Aged; Atrophy; Cholecystitis; Cholelithiasis; Chronic Disease; Colonic Polyps; Diagnosis, Differential; Erythrocyte Count; Erythrocytes; Female; Humans; Inflammation; Intestinal Mucosa; Male; Middle Aged; Motilin; Predictive Value of Tests; Prognosis; Substance P | 2007 |
Mast cell-driven skin inflammation is impaired in the absence of sensory nerves.
Topics: Animals; Calcitonin Gene-Related Peptide; Cell Communication; Denervation; Inflammation; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Neuroimmunomodulation; Sensory Receptor Cells; Signal Transduction; Skin; Substance P | 2008 |
Biochemicals associated with pain and inflammation are elevated in sites near to and remote from active myofascial trigger points.
Topics: Analysis of Variance; Calcitonin Gene-Related Peptide; Capillary Electrochromatography; Electrophoresis; Humans; Inflammation; Inflammation Mediators; Interleukin-1beta; Microdialysis; Muscle, Skeletal; Myofascial Pain Syndromes; Neck Pain; Pain Measurement; Serotonin; Specimen Handling; Substance P; Tumor Necrosis Factor-alpha | 2008 |
The role of selected neuropeptides in pathogenesis of atopic dermatitis.
Topics: Adolescent; Adult; Calcitonin Gene-Related Peptide; Case-Control Studies; Dermatitis, Atopic; Female; Humans; Immunoglobulin E; Inflammation; Male; Middle Aged; Neuropeptide Y; Pain Measurement; Pruritus; Severity of Illness Index; Skin; Substance P | 2008 |
Spinal subarachnoid adrenal medullary transplants reduce hind paw swelling and peripheral nerve transport following formalin injection in rats.
Topics: Adrenal Medulla; Afferent Pathways; Animals; Axonal Transport; Chromaffin Cells; Disease Models, Animal; GAP-43 Protein; Immunohistochemistry; Inflammation; Ligation; Male; Neurons, Afferent; Pain Measurement; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Substance P | 2008 |
Force-dependent development of neuropathic central pain and time-related CCL2/CCR2 expression after graded spinal cord contusion injuries of the rat.
Topics: Animals; Calcitonin Gene-Related Peptide; Chemokine CCL2; Gene Expression; Hyperalgesia; Immunohistochemistry; Inflammation; Lumbosacral Region; Male; Motor Activity; Neuralgia; Pain Measurement; Rats; Rats, Inbred LEC; Receptors, CCR2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord Injuries; Substance P; Thoracic Vertebrae; Time; TRPV Cation Channels | 2008 |
Continued inhalation of lidocaine suppresses antigen-induced airway hyperreactivity and airway inflammation in ovalbumin-sensitized guinea pigs.
Topics: Administration, Inhalation; Anesthetics, Local; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Capsaicin; Cell Count; Cough; Eosinophils; Guinea Pigs; Histamine; Inflammation; Lidocaine; Lung; Male; Ovalbumin; Substance P | 2008 |
From topical antidote against skin irritants to a novel counter-irritating and anti-inflammatory peptide.
Topics: Administration, Cutaneous; Animals; Anti-Infective Agents, Local; Cells, Cultured; Dose-Response Relationship, Drug; Guinea Pigs; Histones; Hot Temperature; Inflammation; Keratinocytes; Male; Mice; Mice, Inbred ICR; Mustard Gas; Neutrophils; Oligopeptides; Peptide Fragments; Povidone-Iodine; Protective Agents; Respiratory Burst; Skin; Skin Irritancy Tests; Substance P; Transfection | 2008 |
Pro-inflammatory effects of hydrogen sulphide on substance P in caerulein-induced acute pancreatitis.
Topics: Acute Disease; Alkynes; Animals; Ceruletide; Cystathionine beta-Synthase; Glycine; Hydrogen Sulfide; Inflammation; Male; Mice; Pancreatitis; Random Allocation; Receptors, Neurokinin-1; RNA, Messenger; Substance P | 2008 |
Influence of substance-P on cultured sebocytes.
Topics: Acne Vulgaris; Cell Differentiation; Cells, Cultured; Cytokines; Epithelial Cells; Gene Expression Regulation; Humans; Inflammation; Lipogenesis; Neuroimmunomodulation; PPAR gamma; Sebaceous Glands; Sebum; Substance P | 2008 |
Neurogenic extravasation and substance P levels are low in muscle as compared to skin the rat hindlimb.
Topics: Animals; Capillary Permeability; Edema; Evans Blue; Inflammation; Muscles; Peripheral Nerves; Rats; Skin; Substance P | 1984 |
A substance P antagonist, [D-Pro2, D-Trp7,9]SP, inhibits inflammatory responses in the rabbit eye.
Topics: Animals; Eye Diseases; Inflammation; Infrared Rays; Pupil; Rabbits; Structure-Activity Relationship; Substance P | 1981 |
A comparison of the miotic and inflammatory effects of biologically active polypeptides and prostaglandin E2 on the rabbit eye.
Topics: Animals; Bradykinin; Eledoisin; Eye; Inflammation; Intraocular Pressure; Miotics; Peptide Fragments; Peptides; Pituitary Hormones, Posterior; Prostaglandins E; Rabbits; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 1982 |
[Substance P - an old neuropeptide in new significant positions].
Topics: Animals; Dopamine; Humans; Inflammation; Nociceptors; Peristalsis; Research; Substance P; Synaptic Transmission | 1982 |
The role of the N-terminal sequence in the biological activities of substance P.
Topics: Amino Acid Sequence; Animals; Inflammation; Receptors, Cell Surface; Receptors, Neurokinin-1; Substance P | 1982 |
Effects of capsaicin on inflammation and on the substance P content of nervous tissues in rats with adjuvant arthritis.
Topics: Animals; Arthritis; Arthritis, Experimental; Capsaicin; Fatty Acids, Unsaturated; Inflammation; Kinetics; Male; Mycobacterium; Nervous System; Rats; Rats, Inbred Strains; Substance P | 1983 |
Bradykinin contracts the pupillary sphincter and evokes ocular inflammation through release of neuronal substance P.
Topics: Animals; Atropine; Bradykinin; Eye; In Vitro Techniques; Inflammation; Neurons; Pupil; Rabbits; Substance P; Tetrodotoxin; Time Factors | 1983 |
Endogenous substance P inhibits the expression of corticotropin-releasing hormone during a chronic inflammatory stress.
Topics: Adrenocorticotropic Hormone; Animals; Arthritis, Experimental; Chronic Disease; Corticotropin-Releasing Hormone; Hypothalamus; Inflammation; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stress, Physiological; Substance P | 1995 |
Time-dependent changes in Bolton-Hunter-labeled 125I-substance P binding in rat spinal cord following unilateral adjuvant-induced peripheral inflammation.
Topics: Animals; Arthritis, Experimental; Autoradiography; Edema; Inflammation; Iodine Radioisotopes; Kinetics; Male; Neurons, Afferent; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Succinimides; Synapses; Synaptic Transmission | 1993 |
Bradykinin-induced airway inflammation. Contribution of sensory neuropeptides differs according to airway site.
Topics: Animals; Asthma; Atropine; Bradykinin; Capillary Permeability; Dipeptides; Evans Blue; Guinea Pigs; Indoles; Indomethacin; Inflammation; Male; Neurons, Afferent; Premedication; Propranolol; Substance P; Tachykinins | 1994 |
Somatostatin analogues suppress the inflammatory reaction in vivo.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Corticotropin-Releasing Hormone; Granuloma; Immunohistochemistry; Inflammation; Male; Octreotide; Peptides, Cyclic; Rats; Somatostatin; Substance P; Tumor Necrosis Factor-alpha | 1994 |
Cytokines, neuropeptides, and reperfusion injury during magnesium deficiency.
Topics: Animals; Calcitonin Gene-Related Peptide; Cardiomyopathies; Cricetinae; Cytokines; Inflammation; Magnesium Deficiency; Myocardial Reperfusion Injury; Neuropeptides; Rats; Reactive Oxygen Species; Substance P; Time Factors; Vitamin E | 1994 |
Direct observation of substance P-induced internalization of neurokinin 1 (NK1) receptors at sites of inflammation.
Topics: Animals; Calcium; Capillary Permeability; Cell Line; Down-Regulation; Endocytosis; Endosomes; Endothelium, Vascular; In Vitro Techniques; Inflammation; Male; Rats; Rats, Inbred F344; Receptors, Neurokinin-1; Signal Transduction; Substance P; Trachea | 1994 |
Effect of a neurokinin-1 (NK1) receptor antagonist on oedema formation induced by tachykinins, carrageenin and an allergic response in guinea-pig skin.
Topics: Animals; Bradykinin; Calcitonin Gene-Related Peptide; Carrageenan; Edema; Guinea Pigs; Indoles; Inflammation; Injections, Intradermal; Isoindoles; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Pyrilamine; Skin; Substance P; Tachykinins | 1994 |
Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity.
Topics: Animals; Antibodies; Calcitonin Gene-Related Peptide; Freund's Adjuvant; Gene Expression; Genes, fos; Hypersensitivity; Inflammation; Nerve Growth Factors; Neurons, Afferent; Rats; Skin; Substance P; Time Factors; Turpentine | 1994 |
Essential role for nitric oxide in neurogenic inflammation in rat cutaneous microcirculation. Evidence for an endothelium-independent mechanism.
Topics: Animals; Arginine; Blood Pressure; Cyclic GMP; Endothelium, Vascular; Indazoles; Inflammation; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Regional Blood Flow; Skin; Substance P | 1995 |
Gelatin sponge-supported histoculture of human nasal mucosa.
Topics: Blood; Cell Count; Culture Media; Culture Techniques; Cytoplasmic Granules; Dinoprost; Gelatin; Histamine; Humans; Immunohistochemistry; Inflammation; Kinins; Mast Cells; Nasal Mucosa; Substance P; Thromboxane B2 | 1995 |
Neurokinin receptors could be differentiated by their capacity to respond to the transglutaminase-synthesized gamma-(glutamyl5)spermine derivative of substance P.
Topics: Animals; Aorta; Blood Pressure; Chemical Phenomena; Chemistry; Collagen; Guinea Pigs; Hindlimb; Ileum; Inflammation; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Rats; Receptors, Tachykinin; Substance P; Transglutaminases; Vasodilation | 1995 |
Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators.
Topics: Animals; Antibodies, Monoclonal; Biphenyl Compounds; Chlorpheniramine; Dihydropyridines; Dose-Response Relationship, Drug; Edema; Female; Guinea Pigs; Imidazoles; Indoles; Inflammation; Isoindoles; Neurokinin-1 Receptor Antagonists; Pyrans; Quinolones; Skin; Substance P; Time Factors | 1995 |
Effects of a new foam formulation of ketoprofen lysine salt in experimental models of inflammation and hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Exudates and Transudates; Female; Gastric Mucosa; Gels; Hyperalgesia; Inflammation; Ketoprofen; Lysine; Male; Prostaglandins; Rats; Rats, Sprague-Dawley; Substance P | 1995 |
Neuroantibodies: ectopic expression of a recombinant anti-substance P antibody in the central nervous system of transgenic mice.
Topics: Animals; Antibodies, Monoclonal; Brain; Escape Reaction; Gene Expression Regulation, Developmental; Inflammation; Mice; Mice, Transgenic; Nerve Growth Factors; Nerve Tissue Proteins; Neuropeptides; Organ Specificity; Promoter Regions, Genetic; Proteins; Rats; Recombinant Fusion Proteins; Substance P; Transcription, Genetic | 1995 |
Contribution of interleukin-1 beta to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Calcitonin Gene-Related Peptide; Dexamethasone; Freund's Adjuvant; Humans; Hyperalgesia; Indomethacin; Inflammation; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Male; Nerve Growth Factors; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sialoglycoproteins; Substance P; Up-Regulation | 1995 |
Investigations on the role of inflammatory and anti-inflammatory agents on the treatment of murine B cell leukemia by recombinant human interleukin-2.
Topics: Animals; Anti-Inflammatory Agents; Bradykinin; Dinoprostone; Freund's Adjuvant; Histamine; Inflammation; Interleukin-2; Leukemia, B-Cell; Lipopolysaccharides; Mice; Mice, Inbred BALB C; p-Methoxy-N-methylphenethylamine; Platelet Activating Factor; Recombinant Proteins; Substance P | 1993 |
A non-peptide NK1-receptor antagonist, RP 67580, inhibits neurogenic inflammation postsynaptically.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Capsaicin; Electric Stimulation; Indoles; Inflammation; Injections, Intravenous; Isoindoles; Male; Morphine; Mucus; Nasal Mucosa; Pyrroles; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Synapses; Thiophenes; Xylenes | 1993 |
A metabolite of substance P, SP7-11 is involved in the pathogenesis of inflammatory joint disease.
Topics: Amino Acid Sequence; Animals; Cartilage; Cells, Cultured; Humans; Inflammation; Joint Diseases; Models, Biological; Molecular Sequence Data; Peptide Fragments; Substance P; Tachykinins | 1993 |
NK1 receptors mediate neurogenic inflammatory increase in blood flow in rat airways.
Topics: Animals; Capsaicin; Inflammation; Male; Microspheres; Neurons, Afferent; Peptidyl-Dipeptidase A; Piperidines; Rats; Rats, Inbred F344; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Regional Blood Flow; Respiratory System; Respiratory Tract Diseases; Substance P; Tachykinins; Vasodilation | 1993 |
Neuropeptide Y inhibits neurogenic inflammation in guinea pig airways.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Autonomic Nervous System; Blood Pressure; Capillary Permeability; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Inflammation; Male; Neuropeptide Y; Parasympatholytics; Pulmonary Circulation; Respiratory System; Substance P; Vagus Nerve | 1993 |
Inhibition of neurogenic inflammation in the meninges by a non-peptide NK1 receptor antagonist, RP 67580.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Dura Mater; Guinea Pigs; Indoles; Inflammation; Injections, Intravenous; Isoindoles; Male; Meninges; Migraine Disorders; Rats; Rats, Wistar; Stereoisomerism; Substance P | 1993 |
Regional content of enteric substance P and vasoactive intestinal peptide during intestinal inflammation in the parasitized ferret.
Topics: Animals; Colon; Ferrets; Ileum; Inflammation; Intestinal Mucosa; Jejunum; Male; Peroxidase; Radioimmunoassay; Substance P; Trichinella spiralis; Trichinellosis; Vasoactive Intestinal Peptide | 1993 |
International Symposium on Substance P and Related Peptides: Pain, Inflammation, Visceral and CNS Functions. Proceedings. Shizuoka, Japan, November 3-6, 1992.
Topics: Animals; Central Nervous System; Humans; Inflammation; Pain; Substance P; Viscera | 1993 |
Substance P-induced inflammation in the rat knee joint is mediated by neurokinin 1 (NK1) receptors.
Topics: Animals; Dipeptides; Indoles; Inflammation; Joints; Male; Rats; Rats, Wistar; Receptors, Neurokinin-2; Regional Blood Flow; Substance P; Vasodilation; Vasodilator Agents | 1993 |
The proportion of CGRP-immunoreactive and SP-mRNA containing dorsal root ganglion cells is increased by a unilateral inflammation of the ankle joint of the rat.
Topics: Animals; Calcitonin Gene-Related Peptide; Freund's Adjuvant; Ganglia, Spinal; In Situ Hybridization; Inflammation; Joints; Neurons; Rats; RNA, Messenger; Substance P; Time Factors | 1993 |
Further evidence that substance P is a mediator of both neurogenic inflammation and pain: two phenomena inhibited either by postsynaptic blockade of NK1 receptors or by presynaptic action of opioid receptor agonists.
Topics: Analgesics; Animals; Anticonvulsants; Electric Stimulation; Formaldehyde; Indoles; Inflammation; Isoindoles; Male; Mice; Mice, Inbred Strains; Morphine; Pain; Peripheral Nerves; Pyrroles; Rats; Rats, Sprague-Dawley; Substance P; Thiophenes | 1993 |
Is the selective non-peptide NK-1 receptor antagonist CP96,345 a peripherally acting analgesic?
Topics: Analgesics; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Inflammation; Male; Mice; Mice, Inbred Strains; Motor Activity; Neurokinin-1 Receptor Antagonists; Substance P | 1993 |
Non-specific activity of (+/-)CP-96,345 in models of pain and inflammation.
Topics: Animals; Biphenyl Compounds; Carrageenan; Dose-Response Relationship, Drug; Edema; Hyperalgesia; Hypnotics and Sedatives; Inflammation; Neurokinin-1 Receptor Antagonists; Pain; Rats; Stereoisomerism; Substance P; Time Factors; Verapamil | 1993 |
Neuropeptides and skin inflammation.
Topics: Calcitonin Gene-Related Peptide; Dermatitis; Humans; Inflammation; Neuropeptides; Skin; Skin Physiological Phenomena; Somatostatin; Stress, Psychological; Substance P; Vasoactive Intestinal Peptide | 1993 |
Stimulation of angiogenesis by substance P and interleukin-1 in the rat and its inhibition by NK1 or interleukin-1 receptor antagonists.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Indomethacin; Inflammation; Interleukin-1; Male; Neovascularization, Pathologic; Neurokinin-1 Receptor Antagonists; Platelet Activating Factor; Prostaglandins; Rats; Rats, Wistar; Receptors, Interleukin-1; Receptors, Neurokinin-1; Regional Blood Flow; Substance P; Xenon Radioisotopes | 1993 |
Characterization of neurogenic inflammation in the airways of two highly inbred rat strains.
Topics: Animals; Benzamides; Blood Pressure; Bronchi; Capillary Permeability; Capsaicin; Cimetidine; Coloring Agents; Dose-Response Relationship, Drug; Evans Blue; Histamine Antagonists; Indoles; Inflammation; Isoindoles; Methysergide; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrilamine; Rats; Rats, Inbred F344; Rats, Inbred Strains; Receptors, Neurokinin-1; Serotonin; Serotonin Antagonists; Substance P; Trachea | 1995 |
Inhibition of substance P-induced vascular leakage in rat by N-acetyl-neurotensin-(8-13).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Esophagus; Fasting; Inflammation; Male; Neurokinin-1 Receptor Antagonists; Neurotensin; Organ Specificity; Peptide Fragments; Rats; Rats, Sprague-Dawley; Skin; Substance P; Urinary Bladder | 1995 |
Evidence for altered control of hypothalamic CRF in immune-mediated diseases.
Topics: Acute Disease; Animals; Arginine Vasopressin; Arthritis, Experimental; Chronic Disease; Corticotropin-Releasing Hormone; Hypothalamo-Hypophyseal System; Hypothalamus; Inflammation; Mice; Paraventricular Hypothalamic Nucleus; Pituitary-Adrenal System; Stress, Physiological; Substance P | 1995 |
Sensory denervation by neonatal capsaicin treatment exacerbates Mycoplasma pulmonis infection in rat airways.
Topics: Animals; Animals, Newborn; Capsaicin; Denervation; Epithelium; Inflammation; Lung Diseases; Male; Mucous Membrane; Mycoplasma Infections; Neovascularization, Pathologic; Nerve Fibers; Neurons, Afferent; Rats; Rats, Inbred F344; Substance P; Trachea | 1996 |
Substance P (NK1) receptor immunoreactivity on endothelial cells of the rat tracheal mucosa.
Topics: Animals; Arterioles; Biomarkers; Electric Stimulation; Endocytosis; Endosomes; Endothelium, Vascular; Immunohistochemistry; Inflammation; Male; Mucous Membrane; Rats; Rats, Inbred F344; Receptors, Neurokinin-1; Substance P; Trachea; Vagus Nerve; Venules | 1996 |
The effect of intra-articular capsaicin on nerve fibres within the synovium of the rat knee joint.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Immunohistochemistry; Inflammation; Injections, Intra-Articular; Knee Joint; Leukocytes, Mononuclear; Male; Nerve Fibers; Nerve Tissue Proteins; Neuropeptide Y; Neutrophils; Rats; Rats, Wistar; Substance P; Synovial Membrane; Thiolester Hydrolases; Ubiquitin Thiolesterase | 1996 |
Substance P- and vasoactive intestinal polypeptide-immunoreactive innervation in normal and inflamed pouches after restorative proctocolectomy for ulcerative colitis.
Topics: Adult; Aged; Colitis, Ulcerative; Female; Humans; Ileum; Immunohistochemistry; Inflammation; Male; Middle Aged; Nerve Fibers; Postoperative Complications; Proctocolectomy, Restorative; Substance P; Vasoactive Intestinal Peptide | 1996 |
Substance P--an underlying factor for pouchitis? Prospective study of substance P- and vasoactive intestinal polypeptide-immunoreactive innervation and mast cells.
Topics: Adult; Biopsy; Cell Count; Colitis, Ulcerative; Endoscopy, Gastrointestinal; Female; Follow-Up Studies; Humans; Ileum; Immunohistochemistry; Inflammation; Male; Mast Cells; Middle Aged; Nerve Fibers; Postoperative Complications; Proctocolectomy, Restorative; Substance P; Vasoactive Intestinal Peptide | 1996 |
Neurogenic amplification of immune complex inflammation.
Topics: Animals; Antigen-Antibody Complex; Antigens, CD; Bronchoalveolar Lavage Fluid; Capillary Permeability; Complement C5a; Female; Gene Targeting; Immune Complex Diseases; Inflammation; Lung; Lung Diseases; Male; Mice; Mice, Inbred C57BL; Neutrophils; Receptor, Anaphylatoxin C5a; Receptors, Complement; Receptors, Neurokinin-1; Substance P; Tumor Necrosis Factor-alpha | 1996 |
Carbamazepine exerts anti-inflammatory effects in the rat.
Topics: Animals; Anti-Inflammatory Agents; Carbamazepine; Dinoprostone; Dose-Response Relationship, Drug; Edema; Exudates and Transudates; Hyperalgesia; Inflammation; Male; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Reaction Time; Substance P | 1995 |
Lymphatic microcirculation.
Topics: Animals; Calcium; Cattle; Diastole; Edema; Inflammation; Lymphatic System; Reactive Oxygen Species; Stroke Volume; Substance P; Systole | 1996 |
A model for experimental induction of acute temporomandibular joint inflammation in rats: effects of substance P(SP) on neuropeptide-like immunoreactivity.
Topics: Animals; Calcitonin Gene-Related Peptide; Chromatography, High Pressure Liquid; Disease Models, Animal; Inflammation; Male; Neurokinin A; Neuropeptide Y; Neuropeptides; Rats; Rats, Sprague-Dawley; Substance P; Temporomandibular Joint; Temporomandibular Joint Disorders | 1996 |
The spinal contribution of substance P to the generation and maintenance of inflammatory hyperalgesia in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Biphenyl Compounds; Carrageenan; Dose-Response Relationship, Drug; Foot; Formaldehyde; Hot Temperature; Hyperalgesia; Inflammation; Male; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 1996 |
Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons.
Topics: Action Potentials; Animals; Ganglia, Spinal; Inflammation; Male; Nerve Fibers, Myelinated; Nerve Growth Factors; Neurons, Afferent; Pain; Phenotype; Photomicrography; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 1996 |
Influence of several peptidase inhibitors on the pro-inflammatory effects of substance P, capsaicin and collagenase.
Topics: Albumins; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Capillary Permeability; Capsaicin; Captopril; Collagenases; Dose-Response Relationship, Drug; Edema; Glycopeptides; Hindlimb; Indoles; Inflammation; Isoindoles; Male; Matrix Metalloproteinase Inhibitors; Methysergide; Neurokinin-1 Receptor Antagonists; Oligopeptides; Organ Size; Protease Inhibitors; Rats; Rats, Wistar; Serotonin Antagonists; Substance P | 1996 |
Induction of tachykinin gene and peptide expression in guinea pig nodose primary afferent neurons by allergic airway inflammation.
Topics: Animals; Blotting, Northern; Calcitonin Gene-Related Peptide; Female; Gene Expression Regulation; Guinea Pigs; Immunohistochemistry; In Situ Hybridization; Inflammation; Microscopy, Electron, Scanning; Neurokinin A; Neurons, Afferent; Nodose Ganglion; Ovalbumin; Radioimmunoassay; Respiratory Hypersensitivity; RNA, Messenger; Specific Pathogen-Free Organisms; Substance P; Tachykinins; Vaccination | 1996 |
Effect of streptozotocin-diabetes on knee joint inflammation-induced changes in substance P and nerve growth factor in the rat.
Topics: Animals; Diabetic Neuropathies; Inflammation; Joints; Knee; Male; Nerve Growth Factors; Rats; Rats, Wistar; Streptozocin; Substance P | 1996 |
Antiinflammatory and analgesic activity of an inhibitor of neuropeptide amidation.
Topics: Amidine-Lyases; Amino Acid Sequence; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Carrageenan; Edema; Fatty Acids, Monounsaturated; Inflammation; Kinetics; Lyases; Male; Mice; Mixed Function Oxygenases; Multienzyme Complexes; Rats; Rats, Sprague-Dawley; Serotonin; Substance P; Substrate Specificity | 1997 |
Central modulation of Brewer's yeast-induced peripheral inflammation by neuropeptides bradykinin and substance P.
Topics: Analgesics; Animals; Bradykinin; Edema; Inflammation; Male; Pain; Rats; Rats, Sprague-Dawley; Saccharomyces cerevisiae; Substance P | 1996 |
Replication-deficient adenoviral vector for gene transfer potentiates airway neurogenic inflammation.
Topics: Adenoviruses, Human; Animals; Capillary Permeability; Capsaicin; Dexamethasone; Ficusin; Gene Transfer Techniques; Genetic Vectors; Glucocorticoids; Hot Temperature; Inflammation; Male; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Photosensitizing Agents; Piperidines; Protein Denaturation; Rats; Rats, Inbred F344; Receptors, Neurokinin-1; Respiratory System; Substance P; Ultraviolet Rays | 1997 |
Ocular inflammation induced by electroconvulsive treatment: contribution of nitric oxide and neuropeptides mobilized from C-fibres.
Topics: Animals; Aqueous Humor; Capsaicin; Electroconvulsive Therapy; Eye Diseases; Inflammation; Neuropeptides; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rabbits; Receptors, Tachykinin; Substance P | 1997 |
Immunoregulatory effect of substance P in human eosinophil migratory function.
Topics: Adjuvants, Immunologic; Chemotaxis, Leukocyte; Dipeptides; Eosinophils; Humans; Hypersensitivity; In Vitro Techniques; Indoles; Inflammation; Interleukin-5; Male; Neurokinin-1 Receptor Antagonists; Platelet Activating Factor; Recombinant Proteins; Substance P | 1996 |
Inhibition by nociceptin of neurogenic inflammation and the release of SP and CGRP from sensory nerve terminals.
Topics: Animals; Bradykinin; Calcitonin Gene-Related Peptide; Capillary Permeability; Electric Stimulation; Inflammation; Nociceptin; Opioid Peptides; Rats; Sensory Receptor Cells; Substance P; Trachea | 1997 |
A novel motility effect of tachykinins in normal and inflamed colon.
Topics: Animals; Atropine; Colon; Dogs; Female; Hexamethonium; Inflammation; Infusions, Intra-Arterial; Male; Muscle Contraction; Muscle, Smooth; Myoelectric Complex, Migrating; Receptors, Tachykinin; Substance P; Tetrodotoxin | 1997 |
Plasma extravasation and neuropeptide release in human skin as measured by intradermal microdialysis.
Topics: Adult; Axons; Calcitonin Gene-Related Peptide; Capsaicin; Forearm; Histamine; Humans; Inflammation; Iontophoresis; Microdialysis; Pain; Skin; Substance P; Time Factors | 1997 |
Effects of ozone on epithelium and sensory nerves in the bronchial mucosa of healthy humans.
Topics: Adult; Afferent Pathways; Biopsy; Bronchial Diseases; Bronchoalveolar Lavage Fluid; Calcitonin Gene-Related Peptide; Constriction, Pathologic; Epithelium; Exercise; Female; Humans; Inflammation; Male; Mucous Membrane; Oxidants, Photochemical; Ozone; Rest; Substance P; Thiolester Hydrolases; Ubiquitin Thiolesterase | 1997 |
Upregulation of substance P receptors in angiogenesis associated with chronic airway inflammation in rats.
Topics: Animals; Capillaries; Coloring Agents; Endosomes; Endothelium, Vascular; Indoles; Inflammation; Male; Mucous Membrane; Mycoplasma Infections; Neovascularization, Pathologic; Nerve Fibers; Organometallic Compounds; Rats; Rats, Inbred F344; Receptors, Neurokinin-1; Substance P; Trachea; Up-Regulation; Venules | 1997 |
Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma.
Topics: Animals; Ganglia, Spinal; Gene Deletion; Hyperalgesia; Inflammation; Interneurons; Isoenzymes; Ligation; Mice; Mice, Knockout; Neuropeptide Y; Pain; Pain Management; Pain Threshold; Protein Kinase C; Receptors, Neurokinin-1; Sciatic Nerve; Signal Transduction; Spinal Cord; Substance P | 1997 |
Plasma protein extravasation induced in the rat dura mater by stimulation of the parasympathetic sphenopalatine ganglion.
Topics: Acetylcholine; Afferent Pathways; Animals; Atropine; Axons; Blood Pressure; Blood Proteins; Calcitonin Gene-Related Peptide; Capsaicin; Carbachol; Disease Models, Animal; Dura Mater; Electric Stimulation; Exudates and Transudates; Ganglia, Parasympathetic; Inflammation; Injections, Intra-Arterial; Male; Migraine Disorders; Neurons, Afferent; Parasympathetic Fibers, Postganglionic; Parasympathomimetics; Permeability; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Serum Albumin, Bovine; Substance P | 1997 |
Ro 45-2081, a TNF receptor fusion protein, prevents inflammatory responses in the airways.
Topics: Animals; Guinea Pigs; Immunoglobulin gamma-Chains; Immunoglobulin Heavy Chains; Inflammation; Lung Diseases; Male; Pulmonary Edema; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Respiratory Hypersensitivity; Substance P | 1998 |
Cell trafficking, mediator release, and articular metabolism in acute inflammation of innervated or denervated isolated equine joints.
Topics: Animals; Blood Pressure; Cartilage, Articular; Denervation; Dinoprostone; Female; Horses; Inflammation; Interleukin-1; Interleukin-6; Joints; Male; Neutrophils; Orchiectomy; Perfusion; Phosphopyruvate Hydratase; Substance P; Synovial Fluid; Synovial Membrane | 1998 |
Inhaled cromoglycate reduces airway neurogenic inflammation via tachykinin antagonism.
Topics: Administration, Inhalation; Animals; Anti-Asthmatic Agents; Capillary Permeability; Cromolyn Sodium; Dose-Response Relationship, Drug; Inflammation; Male; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Saline Solution, Hypertonic; Specific Pathogen-Free Organisms; Substance P; Tachykinins; Trachea | 1997 |
Role of sensory innervation and mast cells in neurogenic plasma protein exudation into the airway lumen.
Topics: Analysis of Variance; Animals; Blood Proteins; Bronchoalveolar Lavage Fluid; Capillary Permeability; Capsaicin; Chromatography, High Pressure Liquid; Disease Models, Animal; Electric Stimulation; Exudates and Transudates; Histamine; Inflammation; Mast Cells; Neuropeptides; Probability; Rats; Rats, Sprague-Dawley; Reference Values; Substance P; Trachea; Vagus Nerve | 1997 |
Modulation of peripheral inflammation by locally administered hemorphin-7.
Topics: Animals; Blister; Calcitonin Gene-Related Peptide; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Hemoglobins; Hindlimb; Inflammation; Male; Naloxone; Narcotic Antagonists; Nerve Fibers; Opioid Peptides; Peptide Fragments; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Substance P; Vacuum; Wound Healing | 1998 |
5HT1B and 5HT1D receptor mRNA differential co-localization with peptide mRNA in the guinea pig trigeminal ganglion.
Topics: Animals; Calcitonin Gene-Related Peptide; Guinea Pigs; In Situ Hybridization; Inflammation; Male; Nerve Fibers; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; RNA, Messenger; Substance P; Trigeminal Ganglion | 1998 |
Effects of silica exposure on substance P immunoreactivity and preprotachykinin mRNA expression in trigeminal sensory neurons in Fischer 344 rats.
Topics: Air Pollutants; Animals; Dust; Immunohistochemistry; In Situ Hybridization; Inflammation; Inhalation Exposure; Male; Protein Precursors; Rats; Rats, Inbred F344; RNA, Messenger; Silicon Dioxide; Substance P; Tachykinins; Trigeminal Nerve | 1998 |
Chronic exposure to ozone causes tolerance to airway hyperresponsiveness in guinea pigs: lack of SOD role.
Topics: Analysis of Variance; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage; Cell Count; Glycopeptides; Guinea Pigs; Inflammation; Infusions, Intravenous; Insufflation; Leukocytes; Lung; Macrophages; Male; Ozone; Substance P; Superoxide Dismutase | 1998 |
Enhanced secretion of substance P by cytokine-stimulated rat brain endothelium cultures.
Topics: Animals; Autoimmunity; Brain; Cells, Cultured; Central Nervous System; Cytokines; Endothelium; Female; Inflammation; Interferon-gamma; Interleukin-1; Male; Rats; Substance P; Tumor Necrosis Factor-alpha | 1998 |
Substance P diminishes lipopolysaccharide and interferon-gamma-induced TGF-beta 1 production by cultured murine macrophages.
Topics: Animals; Cells, Cultured; Drug Interactions; Inflammation; Interferon-gamma; Interleukin-6; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Peptide Fragments; RNA, Messenger; Substance P; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Up-Regulation | 1998 |
Immunization and challenge with toluene diisocyanate decrease tachykinin and calcitonin gene-related peptide immunoreactivity in guinea pig central airways.
Topics: Animals; Bronchial Provocation Tests; Calcitonin Gene-Related Peptide; Cell Count; Disease Models, Animal; Eosinophils; Guinea Pigs; Immunization; Immunoglobulin G; Immunohistochemistry; Inflammation; Male; Nerve Fibers; Respiratory System; Substance P; Tachykinins; Toluene 2,4-Diisocyanate | 1998 |
Antagonists of sensory neuropeptides inhibit the secondary phase of increased circulation following thermally induced inflammation.
Topics: Animals; Burns; Calcitonin Gene-Related Peptide; Extremities; Inflammation; Male; Microcirculation; Neurokinin A; Rats; Rats, Sprague-Dawley; Substance P | 1998 |
Inflammatory and motor responses by tachykinins in the guinea-pig oesophageal sphincter.
Topics: Animals; Dipeptides; Diphenhydramine; Dose-Response Relationship, Drug; Esophagogastric Junction; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Guinea Pigs; Indoles; Inflammation; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P | 1998 |
Role of neuropeptides in pathogenesis of reflex sympathetic dystrophy.
Topics: Adult; Aged; Bradykinin; Calcitonin Gene-Related Peptide; Female; Humans; Inflammation; Male; Middle Aged; Neuropeptides; Reflex Sympathetic Dystrophy; Substance P; Vasoactive Intestinal Peptide | 1998 |
VCAM-1 expression on human dermal microvascular endothelial cells is directly and specifically up-regulated by substance P.
Topics: Capsaicin; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Humans; Inflammation; Neuroimmunomodulation; RNA, Messenger; Skin; Substance P; T-Lymphocytes; Up-Regulation; Vascular Cell Adhesion Molecule-1 | 1999 |
SR140333, a substance P receptor antagonist, influences morphological and motor changes in rat experimental colitis.
Topics: Animals; Colitis; Colon; Inflammation; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Substance P; Trinitrobenzenesulfonic Acid | 1999 |
Actions of intrathecal diphtheria toxin-substance P fusion protein on models of persistent pain.
Topics: Acute Disease; Animals; Carrageenan; Chronic Disease; Constriction, Pathologic; Diphtheria Toxin; Hyperalgesia; Immunohistochemistry; Inflammation; Injections, Spinal; Male; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Sciatic Nerve; Substance P | 1999 |
Release of substance P, calcitonin gene-related peptide and prostaglandin E2 from rat dura mater encephali following electrical and chemical stimulation in vitro.
Topics: Afferent Pathways; Animals; Arachnoid; Bradykinin; Calcitonin Gene-Related Peptide; Dinoprostone; Dura Mater; Electric Stimulation; Headache; Histamine; Inflammation; Male; Migraine Disorders; Neurons, Afferent; Nociceptors; Organ Culture Techniques; Rats; Rats, Wistar; Serotonin; Substance P; Trigeminal Ganglion; Vasodilation | 1999 |
Lack of evidence for tachykinin NK1 receptor-mediated neutrophil accumulation in the rat cutaneous microvasculature by thermal injury.
Topics: Abdomen; Animals; Bradykinin; Burns; Dose-Response Relationship, Drug; Edema; Hindlimb; Histamine; Inflammation; Interleukin-1; Male; Microcirculation; Mustard Plant; Neurokinin-1 Receptor Antagonists; Neutrophils; Peptide Fragments; Piperidines; Plant Extracts; Plant Oils; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Skin; Substance P; Time Factors | 1999 |
Inhibitory effects of tachykinin receptor antagonists on thermally induced inflammatory reactions in a rat model.
Topics: Animals; Burns; Disease Models, Animal; Edema; Follow-Up Studies; Inflammation; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Skin Diseases; Substance P | 1999 |
In vitro prostanoid release from spinal cord following peripheral inflammation: effects of substance P, NMDA and capsaicin.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Capsaicin; Carrageenan; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Ibuprofen; In Vitro Techniques; Inflammation; Knee Joint; Male; N-Methylaspartate; Prostaglandins; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Thromboxane B2 | 1999 |
Substance P primes the formation of hydrogen peroxide and nitric oxide in human neutrophils.
Topics: Adult; Fluoresceins; Humans; Hydrogen Peroxide; Inflammation; Neurotransmitter Agents; Neutrophils; Nitric Oxide; Oxidants; Oxidation-Reduction; Substance P; Superoxides | 1999 |
Transmission of chronic nociception by spinal neurons expressing the substance P receptor.
Topics: Animals; Dose-Response Relationship, Drug; Ganglia, Spinal; Immunotoxins; Inflammation; Ligation; N-Glycosyl Hydrolases; Neuralgia; Pain; Plant Proteins; Posterior Horn Cells; Rats; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Spinal Nerves; Substance P; Time Factors | 1999 |
New feelings about the role of sensory nerves in inflammation.
Topics: Animals; Calcitonin Gene-Related Peptide; Chymases; Hydrolysis; Inflammation; Inflammation Mediators; Neurons, Afferent; Rats; Receptor, PAR-2; Receptors, Thrombin; Serine Endopeptidases; Substance P; Trypsin; Tryptases | 2000 |
Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism.
Topics: Animals; Base Sequence; Calcitonin Gene-Related Peptide; Chymases; DNA Probes; Ganglia, Spinal; Humans; In Situ Hybridization; Inflammation; Male; Neurons; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, PAR-2; Receptors, Thrombin; Serine Endopeptidases; Signal Transduction; Substance P; Trypsin; Tryptases | 2000 |
NK3 receptor blockade prevents hyperalgesia and the associated spinal cord substance P release in monoarthritic rats.
Topics: Afferent Pathways; Animals; Arthritis, Experimental; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Pain; Peptide Fragments; Quinolines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-3; Spinal Cord; Substance P | 2000 |
Interaction between nitric oxide and substance P on heat-induced inflammation in rat paw.
Topics: Analgesics; Animals; Benzamides; Evans Blue; Forelimb; Hyperthermia, Induced; Indoles; Inflammation; Isoindoles; Male; Neurons, Afferent; NG-Nitroarginine Methyl Ester; Nitric Oxide; Piperidines; Rats; Rats, Sprague-Dawley; Skin; Substance P | 2000 |
Parallel increase in substance P and VIP in rat duodenum in response to irradiation.
Topics: Animals; Duodenum; Female; Fluorescent Antibody Technique; Histocytochemistry; Inflammation; Intestinal Mucosa; Muscle, Smooth, Vascular; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Substance P; Vasoactive Intestinal Peptide | 2000 |
Substance P mediates inflammatory oedema in acute pancreatitis via activation of the neurokinin-1 receptor in rats and mice.
Topics: Acute Disease; Amylases; Animals; Blood Pressure; Ceruletide; Edema; Gastrointestinal Agents; Inflammation; Male; Mice; Neurokinin-1 Receptor Antagonists; Pancreatitis; Peroxidase; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P | 2000 |
Deficits in visceral pain and hyperalgesia of mice with a disruption of the tachykinin NK1 receptor gene.
Topics: Acetic Acid; Animals; Behavior, Animal; Capsaicin; Colon; Cyclophosphamide; Cystitis; Female; Hyperalgesia; Inflammation; Male; Mice; Mice, Knockout; Mustard Plant; Nociceptors; Pain; Physical Stimulation; Plant Extracts; Plant Oils; Receptors, Neurokinin-1; Substance P; Urinary Bladder; Visceral Afferents | 2000 |
Effects of topically applied capsaicin cream on neurogenic inflammation and thermal sensitivity in rats.
Topics: Administration, Topical; Animals; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Electric Stimulation; Inflammation; Male; Neurokinin-1 Receptor Antagonists; Pain Threshold; Rats; Rats, Sprague-Dawley; Substance P | 2000 |
Time-dependent changes in neurokinin(3) receptors and tachykinins during adjuvant-induced peripheral inflammation in the rat.
Topics: Animals; Freund's Adjuvant; Inflammation; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; RNA, Messenger; Spinal Cord; Substance P; Tachykinins; Time Factors | 2000 |
Inflammation-induced changes in primary afferent-evoked release of substance P within trigeminal ganglia in vivo.
Topics: Animals; Calcium; Capsaicin; Cell Communication; Electric Stimulation; Guinea Pigs; Inflammation; Male; Membrane Potentials; Neurons, Afferent; Nociceptors; Pain; Pain Threshold; Substance P; Trigeminal Ganglion | 2000 |
Reduced inflammation in genetically hypertensive rat airways is associated with reduced tachykinin NK(1) receptor numbers.
Topics: Animals; Binding, Competitive; Capillary Permeability; Diterpenes; Hypertension; Inflammation; Male; Membranes; Piperidines; Quinuclidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Spinal Cord; Substance P; Trachea; Tritium | 2000 |
Substance P is a determinant of lethality in diet-induced hemorrhagic pancreatitis in mice.
Topics: Acute Disease; Animals; Choline Deficiency; Death; Diet; Ethionine; Hemorrhage; Inflammation; Lung; Mice; Mice, Inbred C57BL; Mice, Knockout; Necrosis; Neprilysin; Neutrophils; Pancreatitis; Peroxidase; Receptors, Neurokinin-1; Substance P | 2000 |
[The neurogenic mechanisms of ocular inflammation and their modulation under local treatment with indomethacin].
Topics: Animals; Anterior Chamber; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor; Capillary Permeability; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Indomethacin; Inflammation; Neurokinin A; Neurokinin B; Rabbits; Substance P | 2000 |
Activation of silent mechanoreceptive cat C and Adelta sensory neurons and their substance P expression following peripheral inflammation.
Topics: Animals; Carrageenan; Cats; Electrophysiology; Evoked Potentials; Female; Ganglia, Spinal; Inflammation; Male; Mechanoreceptors; Membrane Potentials; Neurons, Afferent; Substance P | 2000 |
Differential role of neurokinin receptors in human lymphocyte and monocyte chemotaxis.
Topics: Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Humans; Indoles; Inflammation; Monocytes; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; T-Lymphocytes | 2000 |
Neuroimmunologic aspects of psoriasis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Biphenyl Compounds; Humans; Immunohistochemistry; Inflammation; Injections, Intralesional; Nerve Growth Factor; Neuroimmunomodulation; Neuropeptides; Peptide T; Psoriasis; Psychoneuroimmunology; Receptors, Nerve Growth Factor; Relaxation Therapy; Skin; Stress, Psychological; Substance P | 2000 |
Modulation of inflammation by reactive oxygen species: implications for aging and tissue repair.
Topics: Aging; Animals; Antioxidants; Blister; Blood Flow Velocity; Burns; Inflammation; Laser-Doppler Flowmetry; Male; Pregnatrienes; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Substance P; Suction; Wound Healing | 2001 |
Reduced antinociception and plasma extravasation in mice lacking a neuropeptide Y receptor.
Topics: Animals; Capsaicin; Gene Targeting; Inflammation; Male; Mice; Mice, Inbred BALB C; Mutagenesis; Pain; Pain Threshold; Plasma; Receptors, Neuropeptide Y; Substance P | 2001 |
Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway.
Topics: Animals; Gene Expression Regulation; Genes, fos; Hyperalgesia; Inflammation; Male; Mice; Mice, Knockout; Pain; Prostaglandins; Rats; Rats, Wistar; Receptor, PAR-2; Receptors, Neurokinin-1; Receptors, Thrombin; Spinal Cord; Substance P | 2001 |
Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons.
Topics: Adenosine Triphosphate; Animals; Bradykinin; Calcium; Capsaicin; Cells, Cultured; Chemokines; Fluorescent Dyes; Ganglia, Spinal; HIV Envelope Protein gp120; Hyperalgesia; Inflammation; Intracellular Fluid; Male; Neurons; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, CCR4; Receptors, Chemokine; Receptors, CXCR4; RNA, Messenger; Substance P | 2001 |
Peripheral inflammation reduces the response of spinal dorsal horn neurons to an NK3 receptor agonist.
Topics: Action Potentials; Animals; Carrageenan; Hyperalgesia; Inflammation; Lysine; Neurokinin B; Nociceptors; Pain; Peptide Fragments; Posterior Horn Cells; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P | 2001 |
Substance P, calcitonin gene related peptide and PGE2 co-released from the mouse colon: a new model to study nociceptive and inflammatory responses in viscera, in vitro.
Topics: Animals; Calcitonin Gene-Related Peptide; Colon; Dinoprostone; Female; Hot Temperature; Inflammation; Male; Mice; Pain Measurement; Substance P; Viscera | 2001 |
Pro- and anti-inflammatory actions of ricinoleic acid: similarities and differences with capsaicin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blepharitis; Calcitonin Gene-Related Peptide; Capsaicin; Carrageenan; Cells, Cultured; Drug Synergism; Female; Ganglia, Spinal; Guinea Pigs; Inflammation; Lectins; Male; Neurokinin A; Neurons; Plant Extracts; Plant Lectins; Rats; Ricinoleic Acids; Seeds; Substance P | 2001 |
Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors.
Topics: Acid Sensing Ion Channels; Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; COS Cells; Cyclooxygenase Inhibitors; Ganglia, Spinal; Gene Expression; Hyperalgesia; Inflammation; Lectins; Male; Membrane Proteins; Nerve Tissue Proteins; Neurons, Afferent; Nociceptors; Pain; Pain Measurement; Patch-Clamp Techniques; Rats; Rats, Wistar; RNA, Messenger; Sodium Channel Blockers; Sodium Channels; Substance P; Transfection | 2001 |
Change in excitability and phenotype of substance P and its receptor in cat Abeta sensory neurons following peripheral inflammation.
Topics: Action Potentials; Administration, Topical; Animals; Carrageenan; Cats; Electrophysiology; Fluorescent Dyes; Ganglia, Spinal; Immunohistochemistry; Inflammation; Isoquinolines; Male; Neurons, Afferent; Phenotype; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P | 2001 |
ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity.
Topics: Animals; Butadienes; Disease Models, Animal; Enkephalins; Enzyme Activation; Enzyme Inhibitors; Freund's Adjuvant; Hindlimb; Hyperalgesia; Inflammation; Injections, Spinal; Male; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Pain; Posterior Horn Cells; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spinal Cord; Substance P; Up-Regulation | 2002 |
Alterations of neurokinin receptors and interstitial cells of Cajal during and after jejunal inflammation induced by Nippostrongylus brasiliensis in the rat.
Topics: Animals; Connective Tissue Cells; Immunohistochemistry; Inflammation; Jejunum; Male; Muscle, Smooth; Nippostrongylus; Peroxidase; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Strongylida Infections; Substance P | 2002 |
Role of tachykinins in sephadex-induced airway hyperreactivity and inflammation in guinea pigs.
Topics: Acetylcholine; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchodilator Agents; Capsaicin; Cell Count; Cyclohexylamines; Dextrans; Dose-Response Relationship, Drug; Eosinophils; Guinea Pigs; Indoles; Inflammation; Macrophages; Male; Neurokinin A; Peptides, Cyclic; Receptors, Tachykinin; Substance P; Tachykinins; Time Factors; Vasodilator Agents | 2002 |
In vivo and in vitro effects of bromelain on PGE(2) and SP concentrations in the inflammatory exudate in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bromelains; Carrageenan; Dinoprostone; Exudates and Transudates; Inflammation; Male; Rats; Rats, Sprague-Dawley; Substance P | 2002 |
Capsaicin-sensitive nerve fibres induce epithelial cell proliferation, inflammatory cell immigration and transforming growth factor-alpha expression in the rat colonic mucosa in vivo.
Topics: Animals; Blotting, Western; Bromodeoxyuridine; Calcitonin Gene-Related Peptide; Capsaicin; Cell Division; Colon; Denervation; Goblet Cells; Immunohistochemistry; Inflammation; Intestinal Mucosa; Male; Nerve Fibers; Peroxidase; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Transforming Growth Factor alpha | 2002 |
Neutralizing anti-F glycoprotein and anti-substance P antibody treatment effectively reduces infection and inflammation associated with respiratory syncytial virus infection.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Viral; Cytokines; Female; Inflammation; Lung; Mice; Mice, Inbred BALB C; Neutralization Tests; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Substance P; Treatment Outcome; Viral Proteins; Virus Replication | 2002 |
Interactions of substance P with putative mediators of inflammation and ATP.
Topics: Adenosine Triphosphate; Animals; Bradykinin; Capillary Permeability; Drug Interactions; Histamine; Inflammation; Male; Prostaglandins E; Rats; Serotonin; Substance P | 1977 |
Local secretion of corticotropin-releasing hormone in the joints of Lewis rats with inflammatory arthritis.
Topics: Animals; Arthritis; Arthritis, Experimental; Corticotropin-Releasing Hormone; Dexamethasone; Gene Expression; Inflammation; Joints; Male; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Nude; RNA, Messenger; Substance P; Synovial Membrane | 1992 |
Excitation of cutaneous afferent nerve endings in vitro by a combination of inflammatory mediators and conditioning effect of substance P.
Topics: Animals; Cold Temperature; Electric Stimulation; Hot Temperature; In Vitro Techniques; Inflammation; Male; Mechanoreceptors; Nerve Endings; Neurons, Afferent; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sensory Thresholds; Skin; Substance P | 1992 |
Effects of capsaicin, bradykinin and prostaglandin E2 in the human skin.
Topics: Adult; Axons; Bradykinin; Capsaicin; Dinoprostone; Dose-Response Relationship, Drug; Humans; Indomethacin; Inflammation; Lidocaine; Middle Aged; p-Methoxy-N-methylphenethylamine; Pyrilamine; Skin; Substance P; Tachyphylaxis; Time Factors; Vasodilation | 1992 |
Neuropeptides and inflammation. A somatostatin analog as a selective antagonist of neutrophil activation by substance P.
Topics: Anions; Calcium; Cell Aggregation; Chemotaxis, Leukocyte; Cytosol; GTP Phosphohydrolases; Humans; Inflammation; Neuropeptides; Neutrophils; Octreotide; Substance P; Superoxides | 1992 |
Neonatal capsaicin treatment attenuates spinal Fos activation and dynorphin gene expression following peripheral tissue inflammation and hyperalgesia.
Topics: Animals; Animals, Newborn; Capsaicin; Dynorphins; Enkephalins; Female; Foot Diseases; Gene Expression; Hyperalgesia; Inflammation; Male; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1992 |
Substance P-immunoreactive sensory axons in the rat respiratory tract: a quantitative study of their distribution and role in neurogenic inflammation.
Topics: Animals; Arterioles; Axons; Bronchi; Capsaicin; Ganglia; Histocytochemistry; Inflammation; Male; Muscle, Smooth, Vascular; Neurons, Afferent; Rats; Rats, Inbred F344; Respiratory System; Substance P; Trachea; Vagotomy; Venules | 1992 |
The non-peptide tachykinin antagonist, CP-96,345, is a potent inhibitor of neurogenic inflammation.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Blood Proteins; Evans Blue; Female; Inflammation; Mustard Plant; Plant Extracts; Plant Oils; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Vasoactive Intestinal Peptide | 1992 |
Enhanced release of immunoreactive CGRP and substance P from spinal dorsal horn slices occurs during carrageenan inflammation.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Carrageenan; Edema; In Vitro Techniques; Inflammation; Male; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1992 |
Calcitonin gene-related peptide potentiates substance P-induced plasma extravasation in the rat trachea.
Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Capillary Permeability; Drug Synergism; Evans Blue; Female; Inflammation; Rats; Substance P; Trachea | 1992 |
Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: evidence for a regulatory function of nerve growth factor in vivo.
Topics: Animals; Calcitonin Gene-Related Peptide; Functional Laterality; Ganglia, Spinal; Inflammation; Male; Nerve Growth Factors; Neurons, Afferent; Radioimmunoassay; Rats; Rats, Inbred Strains; Sciatic Nerve; Skin; Spinal Cord; Spinal Nerve Roots; Substance P | 1992 |
International symposium on substance P and related peptides. Pain, inflammation, visceral and CNS functions. November 3-6, 1992, Shizuoka, Japan. Abstracts.
Topics: Animals; Central Nervous System; Digestive System Physiological Phenomena; Humans; Inflammation; Pain; Substance P | 1992 |
Pathobiology of magnesium deficiency: a cytokine/neurogenic inflammation hypothesis.
Topics: Animals; Cytokines; Inflammation; Magnesium Deficiency; Mice; Mice, Inbred BALB C; Models, Biological; Nervous System Physiological Phenomena; Rats; Rats, Sprague-Dawley; Substance P; Time Factors | 1992 |
[Neuropeptides and inflammation: presumed mechanisms in neurogenic inflammation].
Topics: Arthritis; Humans; Inflammation; Mast Cells; Membrane Proteins; Neuropeptides; Substance P | 1990 |
Endotoxin-induced uveitis (EIU) in the rat: a study of inflammatory and immunological mechanisms.
Topics: Animals; Aqueous Humor; Bacterial Toxins; Cell Count; Ciliary Body; Dinoprostone; Endotoxins; Enterotoxins; Eye Proteins; Histocompatibility Antigens Class II; Inflammation; Leukotriene B4; Male; Rats; Rats, Inbred Lew; Substance P; Thromboxane B2; Uveitis | 1990 |
A bradykinin (BK)1 receptor antagonist blocks capsaicin-induced ear inflammation in mice.
Topics: Animals; Bradykinin; Capsaicin; Ear, External; Edema; Inflammation; Male; Mice; Receptors, Bradykinin; Receptors, Neurotransmitter; Substance P | 1990 |
The neuropeptide substance P stimulates production of interleukin 1 in human blood monocytes: activated cells are preferentially influenced by the neuropeptide.
Topics: Cells, Cultured; Humans; Inflammation; Interleukin-1; Lipopolysaccharides; Monocytes; Substance P | 1990 |
Hypertonic saline increases vascular permeability in the rat trachea by producing neurogenic inflammation.
Topics: Animals; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Glycopeptides; In Vitro Techniques; Inflammation; Male; Neurons, Afferent; Neuropeptides; Rats; Rats, Inbred F344; Saline Solution, Hypertonic; Substance P; Trachea | 1990 |
Neurogenic inflammation, vascular permeability, and mast cells. II. Additional evidence indicating that mast cells are not involved in neurogenic inflammation.
Topics: Animals; Capillary Permeability; Cromolyn Sodium; Electric Stimulation; Inflammation; Male; Mast Cells; Mice; Mice, Inbred BALB C; Rats; Rats, Inbred Strains; Skin; Substance P | 1990 |
Substance P causes pain--but also heals.
Topics: Animals; Humans; Inflammation; Pain; Substance P; Wound Healing | 1990 |
Capsaicin pretreatment modifies hydrogen sulphide-induced pulmonary injury in rats.
Topics: Animals; Capsaicin; Hydrogen Sulfide; Inflammation; Lung; Lung Diseases; Male; Microscopy, Electron, Scanning; Neurons, Afferent; Rats; Rats, Inbred F344; Substance P | 1990 |
Serotonin modulates substance P-induced plasma extravasation and vasodilatation in rat skin by an action through capsaicin-sensitive primary afferent nerves.
Topics: Afferent Pathways; Animals; Blister; Capillary Permeability; Capsaicin; Inflammation; Male; Plasma; Rats; Rats, Inbred Strains; Regional Blood Flow; Serotonin; Skin; Substance P; Time Factors; Vasodilation | 1990 |
Modulation of a peripheral inflammatory response to substance P by locally administered opioid receptor agonists.
Topics: Administration, Topical; Amino Acid Sequence; Animals; Blister; Capillary Permeability; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Inflammation; Male; Molecular Sequence Data; Naloxone; Oligopeptides; Perfusion; Peripheral Nerves; Rats; Skin; Substance P; Vasodilation | 1990 |
Inflammatory responses induced by substance P in rat paw.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Female; Histamine Release; Inflammation; Male; Rats; Rats, Inbred Strains; Substance P | 1990 |
Release of immunoreactive substance P in the spinal cord during development of acute arthritis in the knee joint of the cat: a study with antibody microprobes.
Topics: Animals; Arthritis, Experimental; Carrageenan; Cats; Immunoassay; Inflammation; Joints; Kaolin; Pressure; Reference Values; Spinal Cord; Substance P | 1990 |
Neurogenic inflammation induced by capsaicin in patients with psoriasis.
Topics: Administration, Cutaneous; Adult; Age Factors; Capsaicin; Dose-Response Relationship, Drug; Erythema; Forearm; Humans; Inflammation; Psoriasis; Scleroderma, Systemic; Skin; Substance P | 1991 |
Eosinophil activation on biologic surfaces. Production of O2- in response to physiologic soluble stimuli is differentially modulated by extracellular matrix components and endothelial cells.
Topics: Endothelium, Vascular; Eosinophils; Extracellular Matrix; Humans; In Vitro Techniques; Inflammation; Lipopolysaccharides; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Substance P; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1991 |
Effect of neurokinin A, substance P and calcitonin gene related peptide in peripheral hyperalgesia in the rat paw.
Topics: Animals; Calcitonin Gene-Related Peptide; Hyperalgesia; Inflammation; Male; Neurokinin A; Nociceptors; Rats; Rats, Inbred Strains; Substance P | 1991 |
Parathyroid hormone fragment 1-34 inhibits drug-induced inflammation in various experimental models.
Topics: Acetates; Acetic Acid; Animals; Carrageenan; Edema; Inflammation; Male; Nystatin; Parathyroid Hormone; Peptide Fragments; Peritonitis; Rats; Rats, Inbred Strains; Serotonin; Substance P; Teriparatide | 1991 |
The possible role of substance P in the allergic reaction, based on two different provocation models.
Topics: Adult; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Female; Histamine Release; Humans; Hypersensitivity; Inflammation; Male; Nasal Mucosa; Nasal Provocation Tests; Neprilysin; Substance P | 1991 |
Mechanical irritation induces neurogenic inflammation in the rat urethra.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Female; Ganglionectomy; Inflammation; Neurons, Afferent; Rats; Rats, Inbred Strains; Stress, Mechanical; Substance P; Urethra; Urethritis; Urinary Catheterization | 1991 |
Effects of cilazaprilat and enalaprilat on experimental dermatitis in guinea pigs.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Cilazapril; Dermatitis; Drug Synergism; Enalaprilat; Erythema; Female; Guinea Pigs; Inflammation; Ovalbumin; Pyridazines; Substance P | 1991 |
Potent anti-inflammatory action of calcitonin gene-related peptide.
Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Capsaicin; Cricetinae; Edema; Female; Histamine; Humans; Inflammation; Leukotriene B4; Male; Middle Aged; Mouth Mucosa; Rats; Serotonin; Skin; Skin Physiological Phenomena; Substance P | 1991 |
Spantide II, a novel tachykinin antagonist, and galanin inhibit plasma extravasation induced by antidromic C-fiber stimulation in rat hindpaw.
Topics: Amino Acid Sequence; Animals; Autonomic Fibers, Postganglionic; Electric Stimulation; Exudates and Transudates; Foot; Galanin; Inflammation; Molecular Sequence Data; Nerve Fibers; Peptides; Rats; Sciatic Nerve; Substance P; Tachykinins | 1991 |
Substance P: a neurogenic mediator of acute cellular inflammation in the dog?
Topics: Animals; Cell Aggregation; Cells, Cultured; Chemotaxis, Leukocyte; Dogs; Dose-Response Relationship, Drug; Inflammation; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phagocytosis; Substance P | 1991 |
Involvement of substance P in hyperalgesia induced by intrathecal galanin.
Topics: Animals; Antibodies, Monoclonal; Behavior, Animal; Capsaicin; Carrageenan; Galanin; Guinea Pigs; Ileum; In Vitro Techniques; Inflammation; Injections, Spinal; Male; Muscle, Smooth; Neurokinin A; Nociceptors; Pain; Peptides; Rats; Rats, Inbred Strains; Substance P | 1991 |
Neurogenic component of different models of acute inflammation in the rat knee joint.
Topics: Animals; Capsaicin; Carrageenan; Disease Models, Animal; Formaldehyde; Hindlimb; Inflammation; Joints; Male; p-Methoxy-N-methylphenethylamine; Rats; Rats, Inbred Strains; Substance P; Uric Acid | 1991 |
Neurogenic and non-neurogenic inflammation in the rat paw following chemical sympathectomy.
Topics: Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Carrageenan; Edema; Foot; Guanethidine; Inflammation; Mustard Plant; Norepinephrine; Oxidopamine; Plant Extracts; Plant Oils; Rats; Rats, Inbred Strains; Skin; Substance P; Sympathectomy, Chemical | 1991 |
Ruthenium red and capsaicin induce a neurogenic inflammatory response in the rabbit eye: effects of omega-conotoxin GVIA and tetrodotoxin.
Topics: Animals; Aqueous Humor; Calcitonin Gene-Related Peptide; Calcium Channel Blockers; Capsaicin; Eye; Female; Inflammation; Intraocular Pressure; Male; Miosis; Neurokinin A; Nifedipine; omega-Conotoxin GVIA; Peptides, Cyclic; Rabbits; Ruthenium Red; Substance P; Tetrodotoxin | 1991 |
[A pharmacological study of the participation of the peripheral endings of primary afferent neurons in the inflammatory response evoked by heat and mechanical noxious stimulation].
Topics: Animals; Calcitonin Gene-Related Peptide; Electric Stimulation; Hot Temperature; Inflammation; Mice; Neurokinin A; Neurons, Afferent; Neuropeptides; Physical Stimulation; Rats; Substance P | 1990 |
Release of substance P from peripheral nerve terminals following electrical stimulation of the sciatic nerve.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Inflammation; Male; Nerve Endings; Peripheral Nerves; Rats; Rats, Inbred Strains; Substance P | 1985 |
Role of tachykinins in neurogenic inflammation.
Topics: Animals; Eye; Humans; Inflammation; Muscle, Smooth; Muscle, Smooth, Vascular; Nerve Tissue Proteins; Neurotransmitter Agents; Permeability; Skin Physiological Phenomena; Substance P; Tachykinins; Trigeminal Nerve; Vasodilation | 1985 |
The contribution of neurogenic inflammation in experimental arthritis.
Topics: Animals; Arthritis; Arthritis, Experimental; Arthritis, Rheumatoid; Brain Stem; Humans; Inflammation; Nociceptors; Pain; Rats; Spinal Cord; Substance P; Sympathetic Nervous System | 1985 |
Inflammatory oedema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular permeability.
Topics: Animals; Bradykinin; Calcitonin Gene-Related Peptide; Capillary Permeability; Complement C5; Complement C5a, des-Arginine; Dinoprostone; Drug Synergism; Edema; Histamine; Inflammation; Injections, Intradermal; Leukotriene B4; Male; N-Formylmethionine Leucyl-Phenylalanine; Nerve Tissue Proteins; Platelet Activating Factor; Prostaglandins E; Rabbits; Rats; Rats, Inbred Lew; Skin; Species Specificity; Substance P | 1985 |
Reduced neurogenic inflammation in streptozotocin-diabetic rats due to microvascular changes but not to substance P depletion.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Inflammation; Male; Microcirculation; Nerve Tissue Proteins; Nociceptors; Rats; Rats, Inbred Strains; Somatostatin; Substance P | 1985 |
Effects of peptide hormones in urate crystal inflammation.
Topics: Animals; beta-Endorphin; Calcitonin; Dinoprostone; Endorphins; Fatty Acids, Essential; Inflammation; Male; Melanocyte-Stimulating Hormones; Neurotensin; Peptides; Prostaglandins E; Rats; Rats, Inbred Strains; Somatostatin; Substance P; Uric Acid | 1985 |
Neurogenic inflammation caused by wool fabric in the rat; possible mediation by substance P.
Topics: Animals; Capillary Permeability; Inflammation; Male; Rats; Rats, Inbred Strains; Skin; Substance P; Vasodilation; Wool | 1986 |
Plasma extravasation induced by dynorphin-(1-13) in rat skin.
Topics: Analgesics; Animals; Dynorphins; Female; Inflammation; Male; Mast Cells; Naloxone; Peptide Fragments; Plasma; Rats; Rats, Inbred Strains; Skin; Substance P | 1986 |
Interaction of bradykinin with substance P on vascular permeability and pain response.
Topics: Animals; Bradykinin; Capillary Permeability; Drug Synergism; Foot; Inflammation; Male; Mice; Pain; Substance P | 1986 |
Substance P and immunoregulation.
Topics: Animals; Humans; Immune System; Inflammation; Lymphocytes; Neuropeptides; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; T-Lymphocytes, Helper-Inducer | 1987 |
Several mediators appear to interact in neurogenic inflammation.
Topics: Animals; Blood Proteins; Calcitonin Gene-Related Peptide; In Vitro Techniques; Inflammation; Neurokinin A; Neurokinin B; Neuropeptides; Rabbits; Rats; Rats, Inbred Strains; Substance P; Vasodilation | 1987 |
Neurogenic plasma extravasation in response to mechanical, chemical and thermal stimuli.
Topics: Animals; Blood Proteins; Capillary Permeability; Chemoreceptor Cells; Inflammation; Male; Mechanoreceptors; Neuritis; Rats; Rats, Inbred Strains; Skin; Substance P; Thermoreceptors | 1987 |
The effect of substance P on the regional lymph node antibody response to antigenic stimulation in capsaicin-pretreated rats.
Topics: Animals; Animals, Newborn; Antibody Formation; Antigens; Capsaicin; Inflammation; Injections, Subcutaneous; Leukocyte Count; Lymph Nodes; Neurons, Afferent; Rats; Rats, Inbred Strains; Substance P | 1987 |
Leukotriene B4, platelet-activating factor and substance P as mediators of acute inflammation.
Topics: Acute Disease; Animals; Cheek; Cricetinae; Inflammation; Leukotriene B4; Mesocricetus; Mouth Mucosa; Muscles; Platelet Activating Factor; Rabbits; Substance P | 1987 |
Role of neuropeptides, nerves and mast cells in intestinal immunity and physiology.
Topics: Animals; Antibody Formation; Humans; Inflammation; Intestinal Mucosa; Lymphocyte Activation; Lymphocytes; Mast Cells; Neuropeptides; Receptors, Cell Surface; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 1988 |
Substance-P-like levels in inflammatory exudates.
Topics: Animals; Calcium Pyrophosphate; Carrageenan; Exudates and Transudates; Immunoenzyme Techniques; Inflammation; Male; Pleural Effusion; Rats; Substance P | 1988 |
Pathophysiological significance of the distribution of histamine receptor sub-types: a proposed dual role for histamine in inflammation and type I hypersensitivity reactions.
Topics: Animals; Cimetidine; Female; Guinea Pigs; Histamine; Humans; Hypersensitivity; In Vitro Techniques; Inflammation; Male; N-Formylmethionine Leucyl-Phenylalanine; Receptors, Histamine; Substance P | 1988 |
VIP modulates substance P-induced plasma extravasation in vivo.
Topics: Animals; Drug Synergism; Female; Inflammation; Male; Rats; Rats, Inbred Strains; Regional Blood Flow; Skin; Substance P; Vasoactive Intestinal Peptide; Vasodilation | 1988 |
Inflammatory cells and the epithelium. Mast cell/nerve interactions in the lung in vitro and in vivo.
Topics: Animals; Basophils; Epithelium; In Vitro Techniques; Inflammation; Lung; Mast Cells; Nervous System; Nervous System Physiological Phenomena; Rats; Substance P | 1988 |
Substance P induced hydrolysis of inositol phospholipids in rat skin in an in vivo model of inflammation.
Topics: Animals; Blister; Capillary Permeability; Capsaicin; Histamine; Hydrolysis; Inflammation; Phosphatidylinositols; Pyrilamine; Rats; Skin; Substance P | 1989 |
Enhancement of preprotachykinin A gene expression by adjuvant-induced inflammation in the rat spinal cord: possible involvement of substance P-containing spinal neurons in nociception.
Topics: Animals; Gene Expression Regulation; Inflammation; Male; Pain; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger; Sensory Thresholds; Spinal Cord Diseases; Substance P; Tachykinins; Time Factors | 1989 |
Substance P primes human neutrophil activation: a mechanism for neurological regulation of inflammation.
Topics: Cell Movement; Chemotaxis, Leukocyte; Complement C5; Complement C5a; Drug Synergism; Humans; In Vitro Techniques; Inflammation; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Substance P | 1989 |
Effects of lysergic acid diethylamide (LSD) and adjuvant-induced inflammation on desensitization to and metabolism of substance P in the mouse spinal cord.
Topics: Adjuvants, Immunologic; Animals; Drug Tolerance; Female; Inflammation; Lysergic Acid Diethylamide; Male; Mice; Pain; Peptide Fragments; Spinal Cord; Substance P | 1989 |
Photoperiodic variation in substance P induced plasma extravasation in the rat.
Topics: Animals; Corticosterone; Inflammation; Light; Male; Plasma; Rats; Rats, Inbred Strains; Substance P; Time Factors | 1989 |
Substance P and peripheral inflammatory hyperalgesia.
Topics: Animals; Dose-Response Relationship, Drug; Hyperalgesia; Hyperesthesia; Inflammation; Male; Pain; Rats; Rats, Inbred Strains; Substance P | 1989 |
Vasodepression ex vivo after administration of inflammatory mediators in vivo in the rat.
Topics: Alprostadil; Animals; Biological Factors; Bradykinin; Endotoxins; Epoprostenol; Escherichia coli; Female; Histamine; Inflammation; Norepinephrine; p-Methoxy-N-methylphenethylamine; Platelet Activating Factor; Rats; Serotonin; SRS-A; Substance P; Vasoconstriction | 1989 |
Inhibition of carrageenan induced inflammation in the rat knee joint by substance P antagonist.
Topics: Animals; Capsaicin; Carrageenan; Hindlimb; Inflammation; Joints; Peptide Fragments; Rats; Rats, Inbred Strains; Substance P; Synovitis | 1989 |
The role of substance P and calcitonin gene-related peptide in neurogenic plasma extravasation and vasodilatation in the rat.
Topics: Animals; Calcitonin Gene-Related Peptide; Capillary Permeability; Capsaicin; Hindlimb; Immune Sera; Inflammation; Male; Neurons, Afferent; Rats; Rats, Inbred Strains; Substance P; Vasodilation | 1989 |
Sequence of events in substance P-mediated plasma extravasation in rat skin.
Topics: Animals; Female; Histamine; Histamine H1 Antagonists; Inflammation; Male; Neurons; Prostaglandins; Rats; Rats, Inbred Strains; Substance P | 1989 |
Participation of substance P in inflammatory responses.
Topics: Animals; Capsaicin; Dactinomycin; Denervation; Dexamethasone; Edema; Hot Temperature; Inflammation; Male; Rats; Rats, Inbred Strains; Sciatic Nerve; Spinal Nerves; Substance P | 1989 |
Sympathetic neurons modulate plasma extravasation in the rat through a non-adrenergic mechanism.
Topics: Alprostadil; Animals; Blister; Hydroxydopamines; Inflammation; Male; Neurons; Neurons, Afferent; Neurons, Efferent; Nociceptors; Norepinephrine; Oxidopamine; Pain; Plasma; Prostaglandins; Rats; Rats, Inbred Strains; Substance P; Sympathectomy, Chemical; Sympathetic Nervous System | 1989 |