substance p has been researched along with Hypoxia in 92 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 8 (8.70) | 18.7374 |
1990's | 45 (48.91) | 18.2507 |
2000's | 32 (34.78) | 29.6817 |
2010's | 7 (7.61) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Gu, Q; Qian, Y; Qu, C; Tan, X; Tang, J; Xu, Y; Yu, Z | 1 |
Ericson, ME; Gupta, K; Gupta, M; Luk, K; Nguyen, J; Simone, DA; Vang, D; Vincent, L | 1 |
Dean, JB; Nichols, NL; Powell, FL; Putnam, RW | 1 |
Xu, F; Zang, N; Zhao, L; Zhuang, J | 1 |
Kumar, GK; Lee, MS; Prabhakar, NR; Raghuraman, G; Sharma, SD | 1 |
Veasey, S | 1 |
Berner, J; Bilkei-Gorzo, A; Lagercrantz, H; Shvarev, Y; Wickström, R | 1 |
Fu, Z; Powell, FL; Wilkinson, KA | 1 |
Chen, KH; Chen, MJ; Lai, YL | 1 |
Ozawa, Y; Takashima, S | 1 |
Laferrière, A; Liu, JK; Moss, IR | 1 |
de Felipe, C; Donnelly, DF; González, C; Prieto-Lloret, J; Rico, AJ; Rigual, R | 2 |
Hayashida, Y; Hirakawa, H; Kawakami, T; Kusakabe, T; Matsuda, H; Takenaka, T | 1 |
Bévengut, M; Burnet, H; Hilaire, G; Viemari, JC | 1 |
Fischer, A; Springer, J | 1 |
Hayashida, Y; Kusakabe, T; Matsuda, H | 2 |
Berner, J; Hökfelt, T; Holgert, H; Lagercrantz, H; Wickström, HR | 1 |
Hayashida, Y; Hirakawa, H; Kawakami, T; Kusakabe, T; Matsuda, H; Oikawa, S; Takenaka, T | 1 |
Laferrière, A; Moss, IR | 2 |
Carpenter, TC; Schomberg, S; Zee, ED | 1 |
Hayashida, Y; Hirakawa, H; Kusakabe, T; Matsuda, H; Oikawa, S | 2 |
Ha, HS; Kim, JC; Kim, MK; Lee, JK; Park, AJ; Park, JH; Song, YS | 1 |
Burgazlioglu, B; Ercan, I; Gozu, RO; Ilcol, YO; Karadag, M; Ursavas, A | 1 |
Pepple, DJ | 1 |
Al-Abri, M; Cross, MD; Douglas, NJ; Mackay, TW; Mills, NL; Newby, DE; Riha, R; Vennelle, M | 1 |
Arregui, A; Barer, GR; Emson, PC | 1 |
Will, JA | 1 |
Furchgott, RF | 1 |
Lagercrantz, H; Prabhakar, NR; Runold, M; von Euler, C; Yamamoto, Y | 1 |
Archer, SL; Hampl, V; Nelson, DP; Weir, EK | 1 |
Fitzgerald, RS; Shirahata, M | 2 |
Cragg, PA; Kou, YR; Prabhakar, NR | 1 |
Brewster, WJ; Diemel, LT; Leach, RM; Tomlinson, DR | 1 |
Archer, SL; Hampl, V; Isaacson, TC; Nelson, DP; Weir, EK | 1 |
Artiukhina, NI; Kolomeĭtseva, IA; Kulikov, MA; Nozdracheva, LV; Oeme, P; Sarkisova, KIu | 1 |
De Sanctis, GT; Green, FH; Jiang, X; King, M; Remmers, JE | 1 |
Cragg, PA; Kou, YR; Prabhakar, NR; Runold, M | 1 |
Kazemi, H; Soto-Arape, I | 1 |
Chen, CF; Chien, CT; Lai, YL; Shiao, HL; Thacker, AA; Zhang, HQ | 1 |
Gouda, E; Kou, YR; Kumar, GK; Prabhakar, NR | 1 |
Chiarenza, AP; Elverdin, JC; Frid, AB; Giglio, MJ | 1 |
Cherniack, NS; Erokwu, B; Haxhiu, MA; Hejal, R; Strohl, KP | 1 |
Okamura, T; Toda, N; Yoshida, K | 1 |
Barnes, PJ; Crawley, D; Evans, TW; McCormack, DG; Rees, RG | 1 |
Cao, H; Lowe, JA; Prabhakar, NR; Snider, RM | 1 |
Hu, H; Jin, X | 1 |
Oeme, P; Opitts, B; Sarkisova, KIu | 1 |
Gingras, JL; Long, WA; Segreti, T; Wasserstein, M | 1 |
Diana, JN; Lai, YL; Thacker, AA | 1 |
Dalmaz, Y; Denoroy, L; Jouvet, M; Pequignot, JM; Poncet, L | 1 |
Gonzalez, C; Lopez-Lopez, JR; Obeso, A; Perez-Garcia, MT; Rocher, A | 1 |
Ellisman, MH; Kawakami, T; Kusakabe, T; Powell, FL; Sawada, H; Takenaka, T | 1 |
Goodyer, C; Laferrière, A; Moss, IR; Paquette, J; Waters, KA | 1 |
Chen, CF; Chen, LW; Chien, CT; Wu, MS | 1 |
Ayajiki, K; Okamura, T; Toda, N | 1 |
Geraghty, DP; Hinrichsen, CF; Mazzone, SB | 2 |
Chiang, LY; Lai, YL | 1 |
Dinger, B; Fidone, SJ; Stensaas, LJ; Wang, ZZ | 1 |
Furukawa, M; Hayashida, Y; Kawakami, T; Kusakabe, T; Matsuda, H; Takenaka, T; Tsukuda, M | 1 |
Armstead, WM; Wilderman, MJ | 1 |
Lai, LC; Lai, YL; Lin, CW | 1 |
Chen, CF; Lai, YL; Wu, HD | 1 |
Bamford, OS; Gauda, EB; Northington, FJ | 1 |
Chen, CF; Chen, LW; Lai, YL | 1 |
Gono, Y; Hayashida, Y; Kawakami, T; Kusakabe, T; Matsuda, H; Nagahara, T; Takenaka, T; Tsukuda, M; Yoshida, T | 1 |
Kou, YR; Kumar, GK; Overholt, JL; Prabhakar, NR | 1 |
Ellisman, MH; Hayashida, Y; Kawakami, T; Kusakabe, T; Matsuda, H; Powell, FL; Takenaka, T | 1 |
Kumar, GK; Overholt, JL; Prabhakar, NR; Yu, RK | 1 |
Hayashida, Y; Kawakami, T; Kusakabe, T; Matsuda, H; Takenaka, T | 1 |
Hayashida, Y; Kawakami, T; Kusakabe, T; Matsuda, H; Takenaka, T; Yamamoto, Y; Yoshida, T | 1 |
Hori, M; Karaki, H; Murata, T; Ozaki, H; Sato, K; Yamawaki, H | 1 |
Carpenter, TC; Stenmark, KR | 1 |
Kim, DK; Kumar, GK; Prabhakar, NR; Summers, BA | 1 |
Chen, CF; Chu, SJ; Lai, YL; Ma, MC | 1 |
Basbaum, AI; Cao, YQ; Ramirez, JM; Telgkamp, P | 1 |
Chen, J; Yan, H | 1 |
Barnes, PJ; Cuss, FM; Dixon, CM; Fuller, RW; Maxwell, DL | 1 |
Chen, Z; Hedner, J; Hedner, T | 1 |
Serhrouchni, M | 1 |
De Sanctis, GT; Green, FH; Remmers, JE | 1 |
Brodin, E; Goiny, M; Lagercrantz, H; Pantaleo, T; Runold, M; Srinivasan, M; Yamamoto, Y | 1 |
Diemel, LT; Leach, RM; Smith, WJ; Tomlinson, DR | 1 |
Fidone, S; Hanson, G; Jones, L | 1 |
Archer, SL; Chesler, E; Kulik, TJ; Weir, EK | 1 |
Cherniack, NS; Mitra, J; Prabhakar, NR | 1 |
Kane, KA; Kwan, YW; Wadsworth, RM | 1 |
4 review(s) available for substance p and Hypoxia
Article | Year |
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Hypoxic adaptation of the rat carotid body.
Topics: Adaptation, Physiological; Animals; Calcitonin Gene-Related Peptide; Carotid Body; Hypoxia; Neuropeptide Y; Rats; Substance P; Vasoactive Intestinal Peptide | 2005 |
The role of endothelium in the responses of vascular smooth muscle to drugs.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetophenones; Acetylcholine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcimycin; Catechols; Endothelium; Histamine; Hydroquinones; Hypoxia; Masoprocol; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Prostaglandins; Quinacrine; Serotonin; Substance P; Thrombin | 1984 |
Cellular mechanisms of oxygen chemoreception in the carotid body.
Topics: Acetylcholine; Calcium; Carotid Body; Chemoreceptor Cells; Dopamine; Electrophysiology; Hypoxia; NADPH Oxidases; Neurotransmitter Agents; Oxygen; Substance P | 1995 |
Central neuropeptide systems and respiratory control during development.
Topics: Animals; Central Nervous System; Humans; Hypoxia; Neuropeptides; Opioid Peptides; Receptors, Neurokinin-1; Respiratory Mechanics; Substance P | 2002 |
2 trial(s) available for substance p and Hypoxia
Article | Year |
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Continuous positive airway pressure improves vascular function in obstructive sleep apnoea/hypopnoea syndrome: a randomised controlled trial.
Topics: Acetylcholine; Adult; Cardiovascular Diseases; Continuous Positive Airway Pressure; Double-Blind Method; Female; Humans; Hypoxia; Male; Middle Aged; Nitroprusside; Sleep Apnea, Obstructive; Substance P; Vasodilation; Vasodilator Agents | 2008 |
Ventilatory effects of substance P, vasoactive intestinal peptide, and nitroprusside in humans.
Topics: Adult; Blood Pressure; Carotid Body; Ferricyanides; Heart Rate; Humans; Hypercapnia; Hypoxia; Infusions, Intravenous; Male; Nitroprusside; Respiration; Substance P; Vasoactive Intestinal Peptide | 1990 |
86 other study(ies) available for substance p and Hypoxia
Article | Year |
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Substance P Attenuates Hypoxia/Reoxygenation-Induced Apoptosis via the Akt Signalling Pathway and the NK1-Receptor in H9C2Cells.
Topics: Animals; Apoptosis; Blotting, Western; Cells, Cultured; Disease Models, Animal; Hypoxia; Immunohistochemistry; Myocardial Reperfusion Injury; Myocytes, Cardiac; Neurotransmitter Agents; Proto-Oncogene Proteins c-akt; Receptors, Neurokinin-1; Signal Transduction; Substance P | 2018 |
Mast cell activation contributes to sickle cell pathobiology and pain in mice.
Topics: Anemia, Sickle Cell; Animals; Benzamides; Cells, Cultured; Cytokines; Ganglia, Spinal; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hyperalgesia; Hypoxia; Imatinib Mesylate; Leukocyte Count; Mast Cells; Mice; Mice, Knockout; Mice, Transgenic; Microscopy, Confocal; Neurogenic Inflammation; Nociceptors; Pain; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Skin; Substance P | 2013 |
Substance P differentially modulates firing rate of solitary complex (SC) neurons from control and chronic hypoxia-adapted adult rats.
Topics: Action Potentials; Adaptation, Physiological; Animals; Hypoxia; Male; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Solitary Nucleus; Substance P | 2014 |
Prenatal nicotinic exposure augments cardiorespiratory responses to activation of bronchopulmonary C-fibers.
Topics: Animals; Apnea; Brain-Derived Neurotrophic Factor; Bronchoalveolar Lavage Fluid; Capsaicin; Diaphragm; Electromyography; Female; Ganglia; Humans; Hypoxia; Infant, Newborn; Male; Methacholine Chloride; Nerve Fibers, Unmyelinated; Nerve Growth Factor; Nicotine; Nodose Ganglion; Pregnancy; Prenatal Exposure Delayed Effects; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, trkA; Receptor, trkB; Recombinant Proteins; Sensory System Agents; Smoking; Substance P; Sudden Infant Death; TRPV Cation Channels | 2015 |
Intermittent hypoxia activates peptidylglycine alpha-amidating monooxygenase in rat brain stem via reactive oxygen species-mediated proteolytic processing.
Topics: Amidine-Lyases; Animals; Antioxidants; Brain Stem; Disease Models, Animal; Enzyme Activation; Hypoxia; Kinetics; Male; Metalloporphyrins; Mixed Function Oxygenases; Multienzyme Complexes; Neuropeptide Y; Peptide Hydrolases; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Sleep Apnea Syndromes; Substance P | 2009 |
Peptide amidation: a push me, don't pull you for the morbidities in sleep apnea.
Topics: Amidine-Lyases; Animals; Brain Stem; Enzyme Activation; Humans; Hypoxia; Mixed Function Oxygenases; Multienzyme Complexes; Neuropeptide Y; Protein Processing, Post-Translational; Reactive Oxygen Species; Signal Transduction; Sleep Apnea Syndromes; Substance P | 2009 |
Acute morphine effects on respiratory activity in mice with target deletion of the tachykinin 1 gene (Tac1-/-).
Topics: Animals; Animals, Newborn; Brain Stem; Gene Deletion; Hypoxia; In Vitro Techniques; Mice; Morphine; Neurokinin A; Pulmonary Ventilation; Respiration; Substance P; Tachykinins | 2010 |
Ventilatory effects of substance P-saporin lesions in the nucleus tractus solitarii of chronically hypoxic rats.
Topics: Animals; Carbon Dioxide; Consciousness; Hypoxia; Male; Neurons; Oxygen; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Respiratory Physiological Phenomena; Ribosome Inactivating Proteins, Type 1; Saporins; Solitary Nucleus; Substance P | 2011 |
Oxygen radicals and substance P in perinatal hypoxia-exaggerated, monocrotaline-induced pulmonary hypertension.
Topics: Animals; Antioxidants; Atmosphere Exposure Chambers; Blood Pressure; Body Weight; Capsaicin; Female; Heart Rate; Humans; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Reactive Oxygen Species; Sensory System Agents; Substance P | 2012 |
Developmental neurotransmitter pathology in the brainstem of sudden infant death syndrome: a review and sleep position.
Topics: Astrocytes; Brain Stem; Case-Control Studies; Catecholamines; Glial Fibrillary Acidic Protein; Gliosis; Humans; Hypoxia; Infant; Neural Pathways; Neurons; Neurotransmitter Agents; Prone Position; Receptors, Neurotransmitter; Receptors, Serotonin; Respiration; Risk Factors; Serotonin; Substance P; Sudden Infant Death; Supine Position | 2002 |
Neurokinin-1 versus mu-opioid receptor binding in rat nucleus tractus solitarius after single and recurrent intermittent hypoxia.
Topics: Animals; Autoradiography; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Hypoxia; Male; Neuronal Plasticity; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Opioid, mu; Solitary Nucleus; Substance P; Time Factors | 2003 |
Chemoreceptor activity is normal in mice lacking the NK1 receptor.
Topics: Animals; Carotid Body; Catecholamines; Dopamine; Female; Hypoxia; Mice; Mice, Knockout; Neurons, Afferent; Norepinephrine; Receptors, Neurokinin-1; Sensory Receptor Cells; Signal Transduction; Substance P; Superior Cervical Ganglion; Synaptic Transmission; Visceral Afferents | 2002 |
Peptidergic innervation in the rat carotid body after 2, 4, and 8 weeks of hypocapnic hypoxic exposure.
Topics: Animals; Calcitonin Gene-Related Peptide; Carotid Body; Coloring Agents; Eosine Yellowish-(YS); Fluorescent Dyes; Hematoxylin; Hypocapnia; Hypoxia; Immunohistochemistry; Muscle, Smooth, Vascular; Nerve Fibers; Neuropeptide Y; Neuropeptides; Rats; Substance P; Time Factors; Vasoactive Intestinal Peptide | 2003 |
Perinatal maturation of the mouse respiratory rhythm-generator: in vivo and in vitro studies.
Topics: Animals; Animals, Newborn; Electric Stimulation; Hypoxia; Medulla Oblongata; Mice; Norepinephrine; Periodicity; Plethysmography; Respiration; Substance P | 2003 |
Substance P-induced pulmonary vascular remodelling in precision cut lung slices.
Topics: Animals; Cell Division; Culture Techniques; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lung; Mice; Myocytes, Smooth Muscle; Reactive Oxygen Species; Substance P; Transcription Factors | 2003 |
The use of NK-1 receptor null mice to assess the significance of substance P in the carotid body function.
Topics: Animals; Carotid Body; Carotid Sinus; Chemoreceptor Cells; Female; Hypoxia; Immunohistochemistry; In Vitro Techniques; Mice; Mice, Knockout; Receptors, Neurokinin-1; Substance P | 2003 |
Rat carotid bodies in systemic hypoxia. Involvement of arterial CO2 tension in morphological changes.
Topics: Animals; Arteries; Calcitonin Gene-Related Peptide; Carbon Dioxide; Carotid Body; Hypercapnia; Hypoxia; Neuropeptide Y; Rats; Substance P; Vasoactive Intestinal Peptide | 2003 |
Hypoxic response in newborn rat is attenuated by neurokinin-1 receptor blockade.
Topics: Analgesics; Animals; Animals, Newborn; Brain Stem; Disease Models, Animal; Female; Hypoxia; Indoles; Injections, Intraventricular; Isoindoles; Male; Medulla Oblongata; Neurokinin-1 Receptor Antagonists; Proto-Oncogene Proteins c-fos; Pulmonary Ventilation; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Respiration; Respiratory Mechanics; RNA, Messenger; Substance P | 2004 |
Morphological changes in the rat carotid body 1, 2, 4, and 8 weeks after the termination of chronically hypocapnic hypoxia.
Topics: Animals; Calcitonin Gene-Related Peptide; Carotid Body; Chronic Disease; Hypocapnia; Hypoxia; Immunohistochemistry; Nerve Fibers; Neuropeptide Y; Peptide Fragments; Rats; Rats, Wistar; Substance P; Time Factors; Vasoactive Intestinal Peptide | 2004 |
Respiratory responses to intermittent hypoxia in unsedated piglets: relation to substance P binding in brainstem.
Topics: Age Factors; Animals; Autoradiography; Brain Stem; Carbon Dioxide; Hyperventilation; Hypoxia; Oxygen; Partial Pressure; Receptors, Neurokinin-1; Respiration; Respiratory Function Tests; Substance P; Swine; Swine, Miniature | 2004 |
Hypoxia upregulates lung microvascular neurokinin-1 receptor expression.
Topics: Animals; Capillary Permeability; Enzyme-Linked Immunosorbent Assay; Gene Expression; Hypoxia; Immunohistochemistry; Macrophages, Alveolar; Male; Protein Precursors; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Respiratory Distress Syndrome; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Tachykinins; Up-Regulation | 2006 |
Morphological changes in the rat carotid body in acclimatization and deacclimatization to hypoxia.
Topics: Acclimatization; Animals; Calcitonin Gene-Related Peptide; Carotid Body; Chronic Disease; Hypoxia; Neuropeptide Y; Rats; Substance P; Time Factors; Vasoactive Intestinal Peptide | 2006 |
Effect of carbon dioxide on the structure of the carotid body: a comparison between normoxic and hypoxic conditions.
Topics: Animals; Calcitonin Gene-Related Peptide; Carbon Dioxide; Carotid Body; Chronic Disease; Hypercapnia; Hypocapnia; Hypoxia; Neuropeptide Y; Rats; Substance P; Time Factors; Vasoactive Intestinal Peptide; Vasodilation | 2006 |
Endothelial progenitor cells in pterygium pathogenesis.
Topics: Age Distribution; Aged; Chemotactic Factors; Endothelial Cells; Endothelium, Vascular; Female; Humans; Hypoxia; Inflammation Mediators; Leukocyte Count; Male; Middle Aged; Neovascularization, Pathologic; Pterygium; Recurrence; Sex Distribution; Stem Cell Factor; Stem Cells; Substance P; Vascular Endothelial Growth Factor A | 2007 |
Relationship between serum substance P levels and daytime sleepiness in obstructive sleep apnea syndrome.
Topics: Dyssomnias; Female; Humans; Hypoxia; Male; Matched-Pair Analysis; Middle Aged; Polysomnography; Severity of Illness Index; Sleep Apnea, Obstructive; Substance P | 2007 |
The role of hypoxia and substance P in the painful crisis of homozygous sickle cell disease.
Topics: Anemia, Sickle Cell; Hematocrit; Homozygote; Humans; Hypoxia; Models, Biological; Models, Theoretical; Oxygen; Pain; Substance P | 2008 |
Neurochemical studies in the hypoxic brain: substance P, met-enkephalin, GABA and angiotensin converting enzyme.
Topics: Animals; Brain; Brain Chemistry; Endorphins; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Hypoxia; Male; Organ Size; Peptidyl-Dipeptidase A; Rats; Substance P | 1981 |
Neuroendocrine and metabolic factors in pulmonary circulatory control.
Topics: Animals; APUD Cells; Bombesin; Cell Count; Feedback; Hypoxia; Lung; Oxygen Consumption; Pulmonary Circulation; Rabbits; Serotonin; Substance P | 1982 |
Effect of substance P antagonist on the hypoxia-induced carotid chemoreceptor activity.
Topics: Animals; Blood Pressure; Carotid Body; Cats; Female; Hypoxia; Male; Substance P | 1984 |
Chronic EDRF inhibition and hypoxia: effects on pulmonary circulation and systemic blood pressure.
Topics: Animals; Arginine; Blood Pressure; Cardiac Output; Hemodynamics; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Lung; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Organ Size; Perfusion; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Substance P; Vasodilation | 1993 |
Carotid body neurotransmission.
Topics: Acetylcholine; Animals; Carotid Body; Cats; Hypoxia; Pressoreceptors; Substance P; Synaptic Transmission | 1993 |
Role of substance P in rat carotid body responses to hypoxia and capsaicin.
Topics: Animals; Animals, Newborn; Blood Pressure; Capsaicin; Carotid Body; Dose-Response Relationship, Drug; Hypoxia; Neurokinin-1 Receptor Antagonists; Oxygen; Pressoreceptors; Rats; Rats, Sprague-Dawley; Reference Values; Substance P | 1993 |
Reduced sciatic nerve substance P and calcitonin gene-related peptide in rats with short-term diabetes or central hypoxaemia co-exist with normal messenger RNA levels in the lumbar dorsal root ganglia.
Topics: Animals; Blood Glucose; Blotting, Northern; Body Weight; Calcitonin Gene-Related Peptide; Diabetes Mellitus, Experimental; Ganglia, Spinal; Hypoxia; Male; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Sciatic Nerve; Substance P; Tachykinins | 1994 |
Increased endothelium-derived NO in hypertensive pulmonary circulation of chronically hypoxic rats.
Topics: Animals; Arginine; Chronic Disease; Hypertension; Hypoxia; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Substance P; Vasoconstriction | 1994 |
[Effect of substance P on survival of rats after cerebral ischemia: the effect depends on behavior type].
Topics: Animals; Behavior, Animal; Brain Ischemia; Hypoxia; Male; Rats; Rats, Wistar; Substance P | 1993 |
Ventilatory responses to hypoxia in rats pretreated with nonpeptide NK1 receptor antagonist CP-96,345.
Topics: Animals; Animals, Newborn; Biphenyl Compounds; Capsaicin; Female; Hypnotics and Sedatives; Hypoxia; In Vitro Techniques; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Plethysmography; Rats; Rats, Inbred F344; Respiratory Function Tests; Respiratory Mechanics; Substance P; Tidal Volume | 1994 |
Acetylcholine and carotid body excitation during hypoxia in the cat.
Topics: Acetylcholine; Anesthetics; Animals; Blood Gas Analysis; Blood Pressure; Carotid Body; Cats; Hypoxia; Muscarinic Antagonists; Neurotransmitter Agents; Nicotinic Antagonists; Parasympatholytics; Pressoreceptors; Signal Transduction; Substance P | 1994 |
Tachykinin antagonists in carotid body responses to hypoxia and substance P in the rat.
Topics: Action Potentials; Anesthesia; Animals; Blood Pressure; Carotid Arteries; Carotid Body; Female; Hypoxia; Male; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Sodium Bicarbonate; Substance P; Tachykinins | 1994 |
Central glutamate and substance-P in the hypoxic ventilatory response.
Topics: Animals; Dizocilpine Maleate; Glutamic Acid; Hypoxia; Male; Medulla Oblongata; Phrenic Nerve; Rats; Rats, Sprague-Dawley; Respiration; Respiration, Artificial; Substance P | 1994 |
Capsaicin pretreatment attenuates chronic hypoxic pulmonary hypertension.
Topics: Animals; Blood Pressure; Capsaicin; Chronic Disease; Female; Hypertension, Pulmonary; Hypoxia; Neprilysin; Pulmonary Circulation; Random Allocation; Rats; Rats, Wistar; Substance P; Tachykinins | 1995 |
Analysis of carotid chemoreceptor responses to substance P analogue in anaesthetized cats.
Topics: Action Potentials; Animals; Blood Pressure; Carbon Dioxide; Carotid Body; Cats; Chemoreceptor Cells; Female; Hypoxia; Male; Substance P | 1995 |
Effects of chronic hypoxia on the secretory responses of rat salivary glands.
Topics: Animals; Barotrauma; Chronic Disease; Female; Hypoxia; Isoproterenol; Methacholine Chloride; Methoxamine; Parotid Gland; Rats; Rats, Wistar; Saliva; Salivary Glands; Secretory Rate; Stimulation, Chemical; Submandibular Gland; Substance P; Xerostomia | 1995 |
Effect of hypoxia on reflex responses of tracheal submucosal glands.
Topics: Animals; Dogs; Exocrine Glands; Female; Hypoxia; Male; Mucous Membrane; Nerve Endings; Nerve Fibers; Neurons, Afferent; Oxygen Consumption; Pressoreceptors; Reflex; Substance P; Trachea | 1995 |
Potentiation by hypoxia of contractions caused by angiotensin II in dog and monkey cerebral arteries.
Topics: Angiotensin II; Animals; Cerebral Arteries; Constriction, Pathologic; Cyclooxygenase Inhibitors; Dinoprost; Disease Models, Animal; Dogs; Endothelium, Vascular; Female; Hypoxia; Macaca; Male; Substance P | 1993 |
Sensory neuropeptides and hypoxic pulmonary vasoconstriction in the rat.
Topics: Angiotensin II; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Hypoxia; Lung; Male; Neuropeptides; Organ Culture Techniques; Rats; Rats, Wistar; Sciatic Nerve; Substance P; Vasoconstriction | 1993 |
Selective blockade of sensory response of the carotid body to hypoxia by NK-1 receptor antagonist CP-96,345.
Topics: Animals; Biphenyl Compounds; Carotid Body; Cats; Chemoreceptor Cells; Dose-Response Relationship, Drug; Hypoxia; In Vitro Techniques; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Oxygen; Partial Pressure; Receptors, Neurokinin-1; Substance P | 1993 |
[Role of sensory neuropeptides in the responses of pulmonary and cerebral blood vessels to acute hypoxia in rats].
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cerebrovascular Circulation; Hypoxia; Neuropeptides; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Substance P; Vasomotor System | 1996 |
[Effect of substance P fragment (3-4) on the course of cerebral ischemia in rats with different types of behavior].
Topics: Animals; Behavior, Animal; Brain Ischemia; Hypoxia; Male; Neuroprotective Agents; Rats; Substance P | 1996 |
Pre- and postnatal effects of chronic maternal hypoxia on substance-P immunoreactivity in rabbit brainstem regions.
Topics: Animals; Brain Stem; Chronic Disease; Female; Hypoxia; Immunohistochemistry; Pregnancy; Prenatal Exposure Delayed Effects; Rabbits; Substance P | 1995 |
Hypoxemia and elevated tachykinins in rat monocrotaline pneumotoxicity.
Topics: Animals; Hypertension, Pulmonary; Hypoxia; Lung; Male; Monocrotaline; Neprilysin; Pulmonary Gas Exchange; Rats; Rats, Sprague-Dawley; Substance P; Time Factors | 1996 |
Alteration in central and peripheral substance P- and neuropeptide Y-like immunoreactivity after chronic hypoxia in the rat.
Topics: Adrenal Glands; Animals; Antibodies; Brain Chemistry; Carotid Body; Chronic Disease; Ganglia, Sympathetic; Hypoxia; Male; Neuropeptide Y; Pituitary Gland, Anterior; Proteins; Radioimmunoassay; Rats; Rats, Inbred Strains; Substance P | 1996 |
Distribution of substance P and calcitonin gene-related peptide immunoreactive nerve fibers in the trachea of chronically hypoxic rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Chronic Disease; Hypoxia; Immunohistochemistry; Male; Nerve Fibers; Rats; Rats, Sprague-Dawley; Reference Values; Substance P; Trachea | 1996 |
Curtailed respiration by repeated vs. isolated hypoxia in maturing piglets is unrelated to NTS ME or SP levels.
Topics: Aging; Animals; Animals, Newborn; Enkephalin, Methionine; Female; Hypoxia; Male; Recurrence; Respiration; Solitary Nucleus; Substance P; Swine; Swine, Miniature | 1997 |
Renal function of substance P in rats chronically exposed to hypoxia.
Topics: Altitude Sickness; Animals; Chronic Disease; Disease Models, Animal; Female; Glomerular Filtration Rate; Hypoxia; Infusions, Intravenous; Kallikreins; Kidney; Rats; Rats, Wistar; Sodium; Substance P | 1997 |
Hypoxia-induced inhibition of the response to nitroxidergic nerve stimulation in canine cerebral arteries.
Topics: Acidosis; Amiloride; Animals; Cerebral Arteries; Dogs; Female; Hypoxia; Male; Nervous System Physiological Phenomena; Neural Inhibition; Nitric Oxide; Stimulation, Chemical; Substance P; Superoxide Dismutase | 1997 |
Substance P receptors in brain stem respiratory centers of the rat: regulation of NK1 receptors by hypoxia.
Topics: Animals; Hypoxia; Male; Rats; Rats, Wistar; Receptors, Neurokinin-1; Respiration; Respiratory Center; Substance P; Succinimides | 1997 |
Water-soluble fullerene derivatives attenuate exsanguination-induced bronchoconstriction of guinea-pigs.
Topics: Animals; Antidotes; Bronchoconstriction; Carbon; Deferoxamine; Endopeptidases; Expiratory Reserve Volume; Free Radical Scavengers; Fullerenes; Guinea Pigs; Hypoxia; Male; Respiratory System; Substance P | 1997 |
Changes in tyrosine hydroxylase and substance P immunoreactivity in the cat carotid body following chronic hypoxia and denervation.
Topics: Animals; Axons; Carotid Body; Cats; Denervation; Female; Hypoxia; Immunohistochemistry; Male; Reference Values; Substance P; Sympathectomy; Time Factors; Tyrosine 3-Monooxygenase | 1998 |
Substance P- and calcitonin gene-related peptide-containing nerve fibers in the nasal mucosa of chronically hypoxic rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Hypoxia; Immunohistochemistry; Nasal Mucosa; Nerve Fibers; Rats; Substance P; Turbinates | 1998 |
Role of endothelial nitric oxide synthase in hypoxia-induced pial artery dilation.
Topics: Animals; Arteries; Endothelium, Vascular; Enkephalins; Hypoxia; Nitric Oxide; Ornithine; Substance P; Swine; Vasodilation | 1998 |
Attenuation of isocapnic hyperpnoea-induced guinea-pig bronchoconstriction by chronic hypoxia.
Topics: Animals; Bronchial Spasm; Capsaicin; Carbon Dioxide; Chronic Disease; Forced Expiratory Volume; Guinea Pigs; Hypoxia; Lung; Male; Neprilysin; Pulmonary Ventilation; Respiration; Substance P; Trachea | 1998 |
Antioxidants attenuate chronic hypoxic pulmonary hypertension.
Topics: Animals; Antioxidants; Body Weight; Chronic Disease; Free Radicals; Hypertension, Pulmonary; Hypoxia; Male; Rats; Rats, Wistar; Substance P; Thiourea | 1998 |
Hypoxia attenuates the respiratory response to injection of substance P into the nucleus of the solitary tract of the rat.
Topics: Animals; Hypoxia; Injections; Injections, Intraventricular; Male; Rats; Rats, Wistar; Reference Values; Respiration; Solitary Nucleus; Substance P; Tidal Volume | 1998 |
Lack of induction of substance P gene expression by hypoxia and absence of neurokinin 1-receptor mRNAs in the rat carotid body.
Topics: Animals; Carotid Body; Female; Ganglia, Autonomic; Gene Expression Regulation, Enzymologic; Hypoxia; In Situ Hybridization; Pregnancy; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Neurokinin-1; RNA, Messenger; Substance P; Tachykinins; Transcriptional Activation; Tyrosine 3-Monooxygenase | 1998 |
Chronic activation of neurokinin-1 receptor induces pulmonary hypertension in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atmospheric Pressure; Biphenyl Compounds; Blood Pressure; Cardiac Output; Female; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Neurokinin-1 Receptor Antagonists; Pulmonary Wedge Pressure; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Vascular Resistance | 1999 |
Changes in the distribution of the substance P and calcitonin gene-related peptide immunoreactive nerve fibers in the laryngeal mucosa of chronically hypoxic rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Hypoxia; Laryngeal Mucosa; Laryngeal Nerves; Nerve Fibers; Rats; Substance P | 1999 |
Involvement of substance P in neutral endopeptidase modulation of carotid body sensory responses to hypoxia.
Topics: Animals; Biphenyl Compounds; Carotid Body; Cats; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Enkephalin, Methionine; Female; Glycopeptides; Hydrolysis; Hypoxia; Kinetics; Male; Neprilysin; Neurokinin-1 Receptor Antagonists; Oxygen; Receptors, Neurokinin-1; Substance P | 2000 |
Morphological adaptation of the peptidergic innervation to chronic hypoxia in the rat carotid body.
Topics: Adaptation, Physiological; Animals; Calcitonin Gene-Related Peptide; Carotid Body; Hypoxia; Immunohistochemistry; Nerve Fibers; Neuropeptide Y; Neuropeptides; Oxygen; Rats; Substance P; Vasoactive Intestinal Peptide | 2000 |
Role of substance P in neutral endopeptidase modulation of hypoxic response of the carotid body.
Topics: Animals; Carotid Body; Cats; Enkephalin, Methionine; Female; Glycopeptides; Hydrolysis; Hypoxia; In Vitro Techniques; Male; Neprilysin; Neurokinin-1 Receptor Antagonists; Substance P | 2000 |
Changes in the peptidergic innervation of the rat carotid body a month after the termination of chronic hypoxia.
Topics: Animals; Calcitonin Gene-Related Peptide; Carotid Body; Chronic Disease; Hypoxia; Immunohistochemistry; Neuropeptide Y; Neuropeptides; Rats; Substance P; Time Factors; Vasoactive Intestinal Peptide | 2000 |
Changes in the immunoreactivity of substance P and calcitonin gene-related peptide in the laryngeal taste buds of chronically hypoxic rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Hypoxia; Immunoenzyme Techniques; Larynx; Nerve Fibers; Rats; Rats, Wistar; Substance P; Taste Buds | 2000 |
Hypoxia impairs endothelium-dependent relaxation in organ cultured pulmonary artery.
Topics: Animals; Arginine; Biopterins; Caveolin 1; Caveolins; Cyclic GMP; Dinoprost; Dose-Response Relationship, Drug; Endothelium, Vascular; Hypoxia; Ionomycin; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Organ Culture Techniques; Pulmonary Artery; Rabbits; RNA, Messenger; Substance P; Superoxide Dismutase; Vasoconstriction; Vasodilation; Vasodilator Agents | 2001 |
Hypoxia decreases lung neprilysin expression and increases pulmonary vascular leak.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Gene Expression Regulation, Enzymologic; Hypoxia; Lung; Male; Methionine; Microcirculation; Neprilysin; Neurokinin-1 Receptor Antagonists; Oxygen; Piperidines; Protease Inhibitors; Pulmonary Edema; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; RNA, Messenger; Specific Pathogen-Free Organisms; Substance P; Water | 2001 |
Neurotransmitter release from the rabbit carotid body: differential effects of hypoxia on substance P and acetylcholine release.
Topics: Acetylcholine; Animals; Carotid Body; Hypoxia; Male; Rabbits; Substance P | 2001 |
Temporal increase in the reactivity of pulmonary vasculature to substance P in chronically hypoxic rats.
Topics: Altitude; Animals; Blood Pressure; Blood Vessels; Capillaries; Chronic Disease; Female; Hypoxia; In Vitro Techniques; Piperidines; Pulmonary Circulation; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; RNA, Messenger; Substance P; Time Factors | 2002 |
Long-term deprivation of substance P in PPT-A mutant mice alters the anoxic response of the isolated respiratory network.
Topics: Animals; Female; Hypoxia; Male; Mice; Mice, Mutant Strains; Mutation; Periodicity; Protein Precursors; Reference Values; Respiratory System; Substance P; Tachykinins | 2002 |
[Effect of hypoxia on vasodilation induced by substance P (SP) and calcitonin gene-related peptide (CGRP)].
Topics: Animals; Basilar Artery; Calcitonin Gene-Related Peptide; Femoral Artery; Hypoxia; In Vitro Techniques; Rabbits; Renal Artery; Substance P; Vasodilation | 1992 |
Substance P in the ventrolateral medulla oblongata regulates ventilatory responses.
Topics: Animals; Hypoxia; Male; Medulla Oblongata; Rats; Rats, Inbred Strains; Respiratory Mechanics; Substance P | 1990 |
Production of superoxide anion and hydrogen peroxide by KB cells in an anoxia-reoxygenation model, and role of allopurinol.
Topics: Allopurinol; Humans; Hydrogen Peroxide; Hypoxia; Models, Biological; Substance P; Superoxides; Tumor Cells, Cultured; Xanthine Oxidase | 1990 |
Ventilatory responses to hypoxia and hypercapnia in awake rats pretreated with capsaicin.
Topics: Animals; Animals, Newborn; Capsaicin; Chemoreceptor Cells; Hypercapnia; Hypoxia; Nerve Fibers; Rats; Rats, Inbred F344; Respiration; Substance P | 1991 |
Enhanced in vivo release of substance P in the nucleus tractus solitarii during hypoxia in the rabbit: role of peripheral input.
Topics: Animals; Apomorphine; Carotid Sinus; Chemoreceptor Cells; Dialysis; Dopamine; Hypoxia; Medulla Oblongata; Neurons, Afferent; Peripheral Nerves; Phrenic Nerve; Rabbits; Radioimmunoassay; Substance P | 1991 |
Central hypoxaemia in rats provokes neurological defects similar to those seen in experimental diabetes mellitus: evidence for a partial role of endoneurial hypoxia in diabetic neuropathy.
Topics: Animals; Diabetic Neuropathies; Glucose; Hypoxia; Inositol; Male; Nerve Tissue Proteins; Neural Conduction; Peripheral Nervous System Diseases; Rats; Rats, Inbred Strains; Sciatic Nerve; Skin; Sodium-Potassium-Exchanging ATPase; Substance P | 1991 |
Effects of hypoxia on neuropeptide levels in the rabbit superior cervical ganglion.
Topics: Animals; Enkephalin, Methionine; Ganglia, Spinal; Hypoxia; Rabbits; Substance P | 1986 |
The effects of substance P on the preconstricted pulmonary vasculature of the anesthetized dog.
Topics: Acetylcysteine; Animals; Aorta; Atropine; Blood Pressure; Dinoprost; Dogs; Hypoxia; Lung; Meclofenamic Acid; Methylene Blue; Prostaglandins F; Pulmonary Artery; Substance P; Vascular Resistance; Vasoconstriction | 1986 |
Role of substance P in hypercapnic excitation of carotid chemoreceptors.
Topics: Animals; Blood Gas Analysis; Carotid Body; Cats; Female; Hypercapnia; Hypoxia; Male; Oxygen; Substance P | 1987 |
Hypoxia- and endothelium-mediated changes in the pharmacological responsiveness of circumflex coronary artery rings from the sheep.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine; Animals; Cats; Coronary Vessels; Endothelium, Vascular; Hemolysis; Hypoxia; In Vitro Techniques; Isometric Contraction; Muscle, Smooth, Vascular; Nitroprusside; Potassium; Prostaglandin Endoperoxides, Synthetic; Serotonin; Sheep; Substance P; Vasoconstrictor Agents | 1989 |