Page last updated: 2024-08-23

substance p and HIV Coinfection

substance p has been researched along with HIV Coinfection in 21 studies

Research

Studies (21)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	5 (23.81)	18.2507
2000's	10 (47.62)	29.6817
2010's	6 (28.57)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Coveñas, R; Kramer, M; Muñoz, M	1
Douglas, SD; Meshki, J; Spitsin, S; Tuluc, F	1
Barrett, JS; Catalano, R; Douglas, SD; Elci, O; Evans, DL; Kim, D; Korelitz, JJ; Spitsin, S; Tebas, P; Tuluc, F; Wagner, W; Winters, A	1
Baker, K; Barrett, JS; Barrett, K; Douglas, SD; Evans, DL; Lackner, A; Moorthy, G; Spitsin, S; Tulic, F; Winters, A	1
Douglas, SD; Kilpatrick, LE; Lai, JP; Schwartz, L; Tuluc, F	1
Douglas, SD; Evans, DL; Kilpatrick, LE; Lai, JP; Tuluc, F	1
Douglas, SD; Manak, MM; Meshki, J; Moshkoff, DA; Nguyen, LT; Tebas, P; Tuluc, F	1
Barat, C; Bélanger, D; Bertin, J; Tremblay, MJ	1
Leserman, J	1
Douglas, SD; Ho, WZ	1
Douglas, SD; Ho, WZ; Peng, JS; Wan, Q; Wang, X; Zhou, DJ	1
Benton, T; Cnaan, A; Douglas, SD; Evans, DL; Gettes, DR; Lynch, KG; Zhao, H	1
Covas, MJ; Pinto, LA; Victorino, RM	1
Azzari, C; Calabri, G; Carbonella, R; De Martino, M; Galli, L; Resti, M; Rossi, ME; Vierucci, A	1
Barrett, M; Bunker, CB; Mallon, E; Rosenberger, P; Rowe, A; Walsh, J	1
Douglas, SD	1
Abrignani, S; Annunziata, P; Finco, O; Toneatto, S; van der Putten, H	1
Cnaan, A; Douglas, SD; Evans, DL; Gettes, DR; Golden, RN; Ho, WZ; Leserman, J; Petitto, JM; Zhao, H	1
Douglas, SD; Ho, WZ; Li, Y; Song, L; Sun, S	1
Douglas, SD; Ho, WZ; Lai, JP; Li, Y	1
Douglas, SD; Ho, WZ; Lai, JP; Song, L; Wang, X; Yang, JH	1

Reviews

4 review(s) available for substance p and HIV Coinfection

Article	Year
The involvement of the substance P/neurokinin 1 receptor system in viral infection: focus on the gp120 fusion protein and homologous dipeptide domains. Acta virologica, 2019, Volume: 63, Issue:3 Topics: Dipeptides; HIV Envelope Protein gp120; HIV Infections; Humans; Macrophages; Monocytes; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Substance P; Viral Fusion Proteins	2019
Neurokinin 1 receptor isoforms and the control of innate immunity. Trends in immunology, 2009, Volume: 30, Issue:6 Topics: Alternative Splicing; Animals; Chemotaxis; Cytokines; Drug Therapy; HIV Infections; HIV-1; Humans; Immunity, Innate; Macrophages; Protein Isoforms; Receptors, Neurokinin-1; Substance P; Virus Replication	2009
HIV disease progression: depression, stress, and possible mechanisms. Biological psychiatry, 2003, Aug-01, Volume: 54, Issue:3 Topics: Catecholamines; Depression; Disease Progression; Glucocorticoids; HIV Infections; Humans; Stress, Psychological; Substance P	2003
Substance P and neurokinin-1 receptor modulation of HIV. Journal of neuroimmunology, 2004, Volume: 157, Issue:1-2 Topics: Animals; HIV Infections; Humans; Models, Biological; Neuroimmunomodulation; Receptors, Neurokinin-1; Substance P	2004

Trials

1 trial(s) available for substance p and HIV Coinfection

Article	Year
Reduction of soluble CD163, substance P, programmed death 1 and inflammatory markers: phase 1B trial of aprepitant in HIV-1-infected adults. AIDS (London, England), 2015, May-15, Volume: 29, Issue:8 Topics: Adult; Anti-HIV Agents; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Aprepitant; Biomarkers; CD4 Lymphocyte Count; Dose-Response Relationship, Drug; Double-Blind Method; Female; HIV Infections; HIV-1; Humans; Lipoproteins, HDL; Lipoproteins, LDL; Male; Middle Aged; Morpholines; Neurokinin-1 Receptor Antagonists; Programmed Cell Death 1 Receptor; Prospective Studies; Receptors, Cell Surface; Receptors, Neurokinin-1; Substance P; Young Adult	2015

Article

Year

Reduction of soluble CD163, substance P, programmed death 1 and inflammatory markers: phase 1B trial of aprepitant in HIV-1-infected adults.

AIDS (London, England), 2015, May-15, Volume: 29, Issue:8

Topics: Adult; Anti-HIV Agents; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Aprepitant; Biomarkers; CD4 Lymphocyte Count; Dose-Response Relationship, Drug; Double-Blind Method; Female; HIV Infections; HIV-1; Humans; Lipoproteins, HDL; Lipoproteins, LDL; Male; Middle Aged; Morpholines; Neurokinin-1 Receptor Antagonists; Programmed Cell Death 1 Receptor; Prospective Studies; Receptors, Cell Surface; Receptors, Neurokinin-1; Substance P; Young Adult

2015

Other Studies

16 other study(ies) available for substance p and HIV Coinfection

Article	Year
HIV infection of macrophages is enhanced in the presence of increased expression of CD163 induced by substance P. Journal of leukocyte biology, 2014, Volume: 96, Issue:1 Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Biomarkers; Female; Gene Expression Regulation; HIV Infections; HIV-1; Humans; Macrophages; Male; Monocytes; Neurotransmitter Agents; Receptors, Cell Surface; Substance P	2014
Pharmacologic rationale for the NK1R antagonist, aprepitant as adjunctive therapy in HIV. Journal of translational medicine, 2016, 05-26, Volume: 14, Issue:1 Topics: Adolescent; Adult; Animals; Anti-Inflammatory Agents; Anxiety; Aprepitant; Chemokines; Female; HIV Infections; Humans; Macaca mulatta; Macrophages; Male; Middle Aged; Monocytes; Morpholines; Neurokinin-1 Receptor Antagonists; Protein Binding; Receptors, Neurokinin-1; Simian Acquired Immunodeficiency Syndrome; Substance P; Viral Load; Virus Replication; Young Adult	2016
Neurokinin-1 receptor expression and function in human macrophages and brain: perspective on the role in HIV neuropathogenesis. Annals of the New York Academy of Sciences, 2008, Volume: 1144 Topics: Adult; Anti-HIV Agents; Brain; Cell Differentiation; Cell Line; Down-Regulation; Female; HIV Infections; Humans; Macrophages; Male; Neuroimmunomodulation; Receptors, CCR5; Receptors, Neurokinin-1; Signal Transduction; Substance P	2008
Anti-HIV-1 activity of the neurokinin-1 receptor antagonist aprepitant and synergistic interactions with other antiretrovirals. AIDS (London, England), 2010, Nov-27, Volume: 24, Issue:18 Topics: Anti-HIV Agents; Aprepitant; Blood-Brain Barrier; Cells, Cultured; Central Nervous System Diseases; Drug Interactions; HIV Infections; HIV-1; Humans; Morpholines; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Signal Transduction; Substance P	2010
Leukotrienes inhibit early stages of HIV-1 infection in monocyte-derived microglia-like cells. Journal of neuroinflammation, 2012, Mar-16, Volume: 9 Topics: Brain; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gene Expression Regulation, Viral; HIV Infections; HIV-1; Humans; Leukotriene B4; Microglia; Substance P; Transfection	2012
An in vitro model of morphine withdrawal manifests the enhancing effect on human immunodeficiency virus infection of human T lymphocytes through the induction of substance P. The American journal of pathology, 2006, Volume: 169, Issue:5 Topics: Biphenyl Compounds; Gene Expression Regulation; HIV; HIV Infections; HIV Long Terminal Repeat; Humans; Jurkat Cells; Morphine; RNA, Messenger; Substance P; Substance Withdrawal Syndrome; T-Lymphocytes; Virus Replication	2006
Elevated substance P levels in HIV-infected women in comparison to HIV-negative women. AIDS research and human retroviruses, 2008, Volume: 24, Issue:3 Topics: Adolescent; Adult; Aged; Female; HIV Infections; Humans; Middle Aged; Substance P	2008
Disturbed immunoregulatory properties of the neuropeptide substance P on lymphocyte proliferation in HIV infection. Clinical and experimental immunology, 1994, Volume: 96, Issue:3 Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; AIDS-Related Complex; CD4-Positive T-Lymphocytes; Concanavalin A; Female; HIV Infections; Humans; In Vitro Techniques; Lymphocyte Activation; Male; Middle Aged; Neuroimmunomodulation; Phytohemagglutinins; Substance P; T-Lymphocyte Subsets	1994
High levels of IgA in HIV-1-perinatally-infected children. Antigen specificity and possible role of increased substance P plasma levels. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 1994, Volume: 5, Issue:4 Topics: Antibody Specificity; Child; Child, Preschool; Female; HIV Antibodies; HIV Infections; HIV-1; Humans; Immunoglobulin A; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Male; Pregnancy; Substance P	1994
Depletion of cutaneous peptidergic innervation in HIV-associated xerosis. The Journal of investigative dermatology, 1999, Volume: 112, Issue:3 Topics: Adult; Aging; Anti-HIV Agents; Calcitonin Gene-Related Peptide; Disease Progression; Female; HIV Infections; Humans; Male; Middle Aged; Nervous System Physiological Phenomena; Peptides; Protein Precursors; Skin; Skin Diseases; Substance P; Thiolester Hydrolases; Ubiquitin Thiolesterase; Vasoactive Intestinal Peptide	1999
Monocytes/macrophages in diagnosis and immunopathogenesis. Clinical and diagnostic laboratory immunology, 1999, Volume: 6, Issue:3 Topics: Diagnosis; HIV Infections; Humans; Immunity; Macrophages; Monocytes; Phagocytosis; Receptors, Immunologic; Substance P	1999
Evidence of blood-brain barrier alteration and activation in HIV-1 gp120 transgenic mice. AIDS (London, England), 1999, Dec-03, Volume: 13, Issue:17 Topics: Animals; Blood-Brain Barrier; HIV Envelope Protein gp120; HIV Infections; HIV-1; Humans; Immunohistochemistry; Intercellular Adhesion Molecule-1; Mice; Mice, Inbred C57BL; Mice, Transgenic; Rats; RNA, Messenger; RNA, Viral; Substance P; Vascular Cell Adhesion Molecule-1	1999
Elevated substance P levels in HIV-infected men. AIDS (London, England), 2001, Oct-19, Volume: 15, Issue:15 Topics: Cohort Studies; Flow Cytometry; HIV Infections; HIV Seronegativity; Homosexuality; Humans; Killer Cells, Natural; Male; Substance P	2001
Substance P enhances HIV-1 replication in latently infected human immune cells. Journal of neuroimmunology, 2001, Dec-03, Volume: 121, Issue:1-2 Topics: Adult; Antineoplastic Agents; Carcinogens; Cell Line; Chloramphenicol O-Acetyltransferase; Gene Expression Regulation, Viral; Gene Products, gag; HIV Infections; HIV Long Terminal Repeat; HIV-1; Humans; Monocytes; Neuroimmunomodulation; Receptors, Neurokinin-1; RNA, Messenger; Substance P; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Virus Replication	2001
HIV enhances substance P expression in human immune cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2002, Volume: 16, Issue:6 Topics: Blood; Cell Line; HIV Envelope Protein gp120; HIV Infections; Humans; Macrophages; Models, Immunological; Recombinant Proteins; RNA, Messenger; Substance P; T-Lymphocytes; Transcriptional Activation; Up-Regulation; Virus Latency	2002
A non-peptide substance P antagonist down-regulates SP mRNA expression in human mononuclear phagocytes. Journal of neuroimmunology, 2002, Volume: 128, Issue:1-2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Autocrine Communication; Biphenyl Compounds; Cells, Cultured; Chemokine CCL7; Chemokine CX3CL1; Chemokines, CX3C; Cytokines; DNA, Complementary; Down-Regulation; Gene Expression Regulation; HIV; HIV Infections; Humans; Interleukin-8; Leukocytes, Mononuclear; Membrane Proteins; Monocyte Chemoattractant Proteins; Neuroimmunomodulation; Oligonucleotide Array Sequence Analysis; Phagocytes; Receptors, Neurokinin-1; RNA, Messenger; Substance P; Virus Replication	2002