substance p has been researched along with Disease Models, Animal in 587 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (1.70) | 18.7374 |
| 1990's | 75 (12.78) | 18.2507 |
| 2000's | 238 (40.55) | 29.6817 |
| 2010's | 235 (40.03) | 24.3611 |
| 2020's | 29 (4.94) | 2.80 |
| Authors | Studies |
|---|---|
| Dong, X; Han, L; Kulka, M; McNeil, BD; Meeker, S; Pundir, P; Undem, BJ | 1 |
| Hsieh, YL; Yang, CC; Yang, NP | 1 |
| Farahani, ZK; Ferrero, H; Naderi, MM; Taherianfard, M | 1 |
| Choi, ES; Ham, HD; Lee, C; Lee, CH; Lee, S; Park, JH | 1 |
| Adachi, N; Ishikawa, M; Kanemitsu, M; Miyaki, S; Nakasa, T; Nekomoto, A; Shirakawa, Y; Yimiti, D | 1 |
| Di, T; Fu, J; Guo, J; Guo, X; Li, P; Liu, Q; Liu, Y; Meng, Y; Qi, C; Wang, Y; Zhang, L; Zhao, J | 1 |
| Feng, N; Han, G; Hou, X; Li, Y; Liu, W; Wu, H; Xing, B; Zhang, J | 1 |
| An, H; Dang, B; Ding, Y; Wang, Y; Zhao, C | 1 |
| Becerik, Ç; Karaca, ÇT; Kul, S; Özcan, Z; Toros, SZ | 1 |
| Barr, J; Bell, M; Drapkin, R; Eichwald, T; Fettig, RR; Hooper, JE; Jung, E; Kovács, A; Lucido, CT; Muirhead, DM; Omran, DK; Reavis, H; Restaino, AC; Schwartz, LE; Spanos, WC; Talbot, S; Vermeer, DW; Vermeer, PD; Vermeer, SJ; Walz, A; Williamson, CS | 1 |
| Hong, G | 1 |
| Cao, Y; Liu, Y; Wang, S; Wang, Y; Yang, X; Zhang, W; Zhao, M | 1 |
| Gunes, H; Kilinc, E | 1 |
| Abe, K; Chiba, T; Kambe, T; Kawakami, K; Taguchi, K; Yamamoto, K | 1 |
| Luo, F; Niu, SN; Wang, JA | 1 |
| Ahlström, FHG; Blomqvist, KJ; Jokinen, V; Kalso, EA; Lilius, TO; Rauhala, PV; Sidorova, YA; Suleymanova, I; Viisanen, H | 1 |
| Hnasko, TS; Khom, S; Roberto, M; Steinkellner, T | 1 |
| Hiramoto, S; Irie, Y; Ishikura, H; Kawabata, A; Maeda, M; Nishibori, M; Sekiguchi, F; Tsubota, M; Wake, H | 1 |
| Neelam, S; Niederkorn, JY | 1 |
| Fahmy, A; Hegazy, N; Rezq, S | 1 |
| Buscaglia, P; Fouyet, S; L'Herondelle, K; Le Gall-Ianotto, C; Le Garrec, R; Leschiera, R; Lewis, RJ; Michel, L; Mignen, O; Misery, L; Philippe, R; Pierre, O; Talagas, M | 1 |
| Byun, YS; Chung, SH; Joo, CK; Kim, HS; Mok, JW | 1 |
| Jia, W; Jia, Y; Li, R; Qu, Y; Wan, C; Wang, W; Zhang, W; Zhang, Z; Zhou, Q | 1 |
| Chen, Z; Deng, C; Gao, Y; Hu, JH; Jiang, MH; Liu, M | 1 |
| Guo, N; Hallberg, M; Nyberg, F; Nyman, J; Sandström, A; Yu, L | 1 |
| Abdulnour, RE; Balood, M; Crosson, T; Doyle, B; Foster, SL; Fritz, JH; Huang, X; Lai, NYY; Levy, BD; Majdoubi, A; Merrison, H; Mindt, BC; Ozcan, A; Parrin, A; Pascal, M; Rafei, M; Rajchgot, T; Seehus, CR; Semenara, E; Talbot, S; Thibodeau, J; Wang, JC; Woolf, CJ | 1 |
| Boerman, EM; Franklin, CL; Grunz-Borgmann, EA; Hart, ML; Jones, BW; Norton, CE | 1 |
| Barbariga, M; Bignami, F; Ferrari, G; Fonteyne, P; Lasagni Vitar, RM; Rama, P | 1 |
| Fujita, M; Nakagawasai, O; Nemoto, W; Tan-No, K; Yamagata, R | 1 |
| He, L; Hu, S; Sun, X; Wang, J; Wang, N; Wu, Y; Yang, S; Zhang, T; Zhang, Y | 1 |
| Guan, M; Wang, Y; Ying, S | 1 |
| Chang, CT; Chang, KV; Chen, CC; Chu, YC; Han, DS; Lee, CH; Li, MH; Lin, SH; Shieh, YD; Wang, JL | 1 |
| Chen, YJ; Greenhill, C; Ivanusic, JJ; Kim, DH; Nencini, S; Ringuet, M | 1 |
| Park, KS; Um, J; Yu, J | 1 |
| Dang, NH; Hatano, R; Itoh, T; Kimura, U; Komiya, E; Morimoto, C; Ohnuma, K; Otsuka, H; Suga, Y; Takamori, K; Tominaga, M; Yamada, T; Yamazaki, H | 1 |
| Askan, G; Bailey, JM; Baker, L; Basturk, O; Fu, YY; Grbovic-Huezo, O; Grimont, A; Joo, MG; Ketcham, M; Kurtz, RC; Lafaro, K; Leach, SD; Melchor, JP; Park, Y; Pasricha, PJ; Saglimbeni, JA; Sinha, S; Tuveson, D; Yang, IH; Zhong, Y | 1 |
| Ahn, S; Hong, S; Jang, J; Jeon, S; Jung, YR; Kim, J; Oh, JY; Park, HJ; Park, SU; Shin, HS; Song, MA; Song, TJ | 1 |
| Beaudry, F; Guillot, M; Martel-Pelletier, J; Moreau, M; Otis, C; Pelletier, JP; Troncy, E | 1 |
| Clifton, DK; Krull, AA; Larsen, SA; Neal-Perry, G; Steiner, RA | 1 |
| Abdel, MP; An, KN; Grill, DE; Kremers, HM; Lewallen, DG; Lewallen, EA; Morrey, ME; Reina, N; Salib, CG; Sanchez-Sotelo, J; Steinmann, SP; Trousdale, WH; van Wijnen, AJ; Yao, JJ | 1 |
| Hellman, J; Lawton, SK; Prakash, A; Schumacher, M; Tran, A; Wilhelmsen, K; Wong, E; Xu, F | 1 |
| Byeon, Y; Dubon, MJ; Jung, N; Kim, D; Kim, DY; Park, KS; Son, Y; Um, J | 1 |
| Carroll, RS; Kaiser, UB; León, S; Maguire, CA; Navarro, VM | 1 |
| El-Salhy, M; Gilja, OH; Hatlebakk, JG; Hausken, T; Solomon, T | 1 |
| Demartini, C; Francesconi, O; Greco, R; Nativi, C; Tassorelli, C; Tonsi, G; Zanaboni, AM | 1 |
| Blackcloud, P; Gilmore, ES; Nousari, Y; Pentland, AP; Poligone, B; Ritchlin, CT; Tausk, F; VanBuskirk, J; Vegas, O; Walter, SA | 1 |
| Gu, Q; Qian, Y; Qu, C; Tan, X; Tang, J; Xu, Y; Yu, Z | 1 |
| Guha, R; Hazra, S; Konar, A; Kumar, V; Sur, VP | 1 |
| Honda, T; Kabashima, K; Kitayama, N; Nakashima, C; Nonomura, Y; Otsuka, A; Usui, K; Wong, LS; Yamamoto, Y | 1 |
| Fang, K; Huang, V; Iliopoulos, D; Kevil, CG; Law, IKM; Padua, D; Pothoulakis, C; Sideri, A | 1 |
| Liu, L; Sun, T; Wang, L; Zhang, L | 1 |
| Hong, HS; Kim, S; Son, BK; Son, Y; Yoo, K; Yu, SY | 1 |
| Haruki, N; Hori, M; Inomata, T; Ohgoda, M; Tsukamoto, A | 1 |
| Hong, JW; Jang, SP; Lee, HJ; Lee, JR; Park, SH; Suh, HW | 1 |
| Jia, J; Tu, W; Wu, Y; Xie, C; Xu, Y | 1 |
| Amagase, K; Kato, S; Matsumoto, K; Tominaga, M; Tsukahara, T; Utsumi, D | 1 |
| Chen, C; Dai, J; Han, X; Hu, G; Li, B; Ni, J; Wan, R; Wang, X; Wu, J; Wu, Z; Ye, X | 1 |
| Chacur, M; Martins, DO; Rocha, IRC; Santos, FM; Silva, JT | 1 |
| Barbariga, M; Bignami, F; Ferrari, G; Fonteyne, P; Ostadreza, M; Rama, P | 1 |
| Kang, H; Li, X; Liu, D; Liu, Z; Wu, J; Yang, S; Zeng, B; Zhang, Q; Zhong, Z | 1 |
| Ahn, Y; Hong, HS; Hong, YJ; Jeong, MH; Kim, JH; Kim, W; Lee, KH; Lim, KS; Park, DS; Sim, DS; Son, Y; Song, HC; Woo, JS | 1 |
| Duan, Z; Li, J; Pang, X; Su, Z; Wang, H | 1 |
| Duffy, ER; Mella, JR; Remick, DG; Stucchi, AF | 1 |
| An, S; Fang, X; Hao, J; Tian, F; Wang, J; Zhang, Y | 1 |
| Arkless, KL; Aubdool, AA; Brain, SD; Caton, P; Cleary, SJ; Evans, E; Kee, Z; Kodji, X; Pitchford, SC | 1 |
| Gu, C; Gu, W; Lu, X; Sheng, K; Wu, W; Yue, J; Zhang, H | 1 |
| Demartini, C; Deseure, K; Francesconi, O; Greco, R; Nativi, C; Tassorelli, C; Zanaboni, AM | 1 |
| Deng, H; Huang, C; Jia, J; Tu, W; Wu, Y; Xu, Y; Yang, J | 1 |
| Backman, LJ; Chen, J; El-Habta, R; Pingel, J | 1 |
| Guo, SW; Liu, X; Yan, D | 1 |
| Benetti, F; Briso, ALF; Cintra, LTÂ; Ervolino, E; Gallinari, MO; Rahal, V | 1 |
| Chacur, M; da Silva, JT; Evangelista, BG; Seminowicz, DA; Venega, RAG | 1 |
| Borbély, É; Gaszner, B; Gubányi, T; Hajna, Z; Helyes, Z; Hunyady, Á; Kemény, Á; Scheich, B | 1 |
| Hodges, PW; James, G; Klyne, DM; Millecamps, M; Stone, LS | 1 |
| Chen, CC; Han, DS; Lee, CH; Shieh, YD | 1 |
| Hong, HS; Hwang, DY; Kim, S; Park, JS; Piao, J; Son, Y | 1 |
| Ständer, S; Yosipovitch, G | 1 |
| Arlt, W; Chan, YM; Cole, TR; Farooqi, IS; Fergani, C; Hall, JE; Jones, CM; León, S; Lippincott, MF; Navarro, VM; Seminara, SB; Shaw, ND; Stewart, SE; Talbi, R; Terasawa, E | 1 |
| Andruszkow, H; Andruszkow, J; Greven, J; Hildebrand, F; Hofman, M; Kobbe, P; Kolejewska, A; Lammers, T; Möckel, D; Poeze, M; Rabenschlag, F; Teuben, MPJ | 1 |
| Best, TM; Bowles, AC; Colombini, A; Correa, D; Kaplan, LD; Kouroupis, D; Perucca Orfei, C; Willman, MA | 1 |
| Fujita, S; Kasai, K; Shimizu, M; Utsunomiya, T; Yamaguchi, M; Yamamoto, H | 1 |
| Chang, S; Lei, Q; Malykhina, AP; Pan, XQ; Seftel, AD; Smith, AL; Villamor, AN | 1 |
| Gabrielian, L; Helps, SC; Leonard, AV; Thornton, E; Turner, RJ; Vink, R | 1 |
| Kusaka, E; Senoo, N; Sugimoto, Y; Sugiyama, M; Yamamoto, A | 1 |
| Dong, Z; Gong, Y; Li, X; Shan, B; Shen, L; Shu, X; Wang, Z; Zhang, L | 1 |
| Basbaum, AI; Eberhart, D; Meda, K; Rice, D; Solorzano, C; Urban, R; Wang, X; Yamanaka, H; Zhang, J | 1 |
| Chen, X; Chu, B; Dai, W; Dong, Z; Hu, Y; Liang, J; Pan, M; Yu, S; Zhang, M | 1 |
| Chen, T; Li, YQ; Qu, J; Wang, W; Wang, XL; Wu, SX; Yanagawa, Y; Zhang, T | 1 |
| Chen, R; Lai, K; Li, J; Li, L; Liu, X; Ma, P; Wu, Y; Yang, X; Yao, H; Ye, X; You, H; Yuan, Y | 1 |
| Arakawa, K; Horie, S; Kato, S; Matsumoto, K; Nakajima, T; Narita, M; Sagara, A; Sakai, H; Tashima, K | 1 |
| Lai, QK; Lin, C; Liu, JH; Wu, B | 1 |
| Shi, P; Wang, S; Wang, Y | 1 |
| Chun, J; Khan, S; Kim, YS; Shehzad, O | 1 |
| Leonard, AV; Thornton, E; Vink, R | 2 |
| Dehlin, HM; Levick, SP; Manteufel, EJ; Monroe, AL; Reimer, MH | 1 |
| Bae, TH; Kim, HK; Kim, W; Kim, WS; Lee, JY; Park, JA | 1 |
| Kouchek, M; Takasusuki, T; Terashima, T; Xu, Q; Yaksh, TL | 1 |
| Arora, V; Chopra, K | 1 |
| Jin, HJ; Yang, LM; Yu, L; Zhao, H | 1 |
| Funahashi, H; Ikeda, T; Matsushima, O; Naono-Nakayama, R; Nishimori, T; Sameshima, H; Takamiya, K | 1 |
| Calissano, P; Campolongo, P; Ciotti, MT; Florenzano, F; Marolda, R; Nori, SL; Palmery, M; Possenti, R; Ratano, P; Rinaldi, AM; Severini, C; Zona, C | 1 |
| Arizpe, HM; Clifford, JL; Fowler, M; Garza, TH; Loyd, DR; Novak, J; Petz, LN; Slater, TM | 1 |
| Baqi, Y; Correa, M; Freeland, C; Hart, EE; López-Cruz, L; Müller, CE; Nunes, EJ; Randall, PA; Salamone, JD; Yohn, SE | 1 |
| Dong, YB; Shang, JJ; Tang, RZ; Xie, JQ; Xu, H; Yuan, JY | 1 |
| Daoud, A; Ma, Y; Tan, G; Wang, T; Xie, Z | 1 |
| Tang, HQ; Wang, BJ; Yang, Y; Ye, JH; Zheng, XL; Zheng, XR | 1 |
| Chen, W; Marvizón, JC; McRoberts, JA | 1 |
| Hamity, MV; Hammond, DL; Walder, RY | 1 |
| Bach, V; Canarelli, JP; Delanaud, S; Gay-Quéheillard, J; Haraux, E; Khorsi, H | 1 |
| Chattopadhyay, S; Dubielzig, RR; Guthrie, KM; McAnulty, JF; Murphy, CJ; Raines, RT; Teixeira, L | 1 |
| Fukui, H; Hattori, T; Kase, Y; Kondo, T; Koseki, J; Miwa, H; Oshima, T; Tomita, T; Watari, J | 1 |
| Du, XP; Han, ZX; Ma, J; Sun, X; Wang, HM; Xu, J | 1 |
| Backman, C; Forsgren, S; Lorentzon, R; Song, Y; Stål, PS; Yu, JG | 1 |
| Chen, R; Ding, F; Lin, D; Liu, K; Liu, R; Liu, Y; Ran, H; Sun, Y; Wang, J; Wang, Q; Wang, Y | 1 |
| Feixia, L; Jia, Z | 1 |
| Deng, X; Fu, SK; Li, J; Ren, L; Sun, JD; Zhao, SZ | 1 |
| Ghabriel, MN; Harford-Wright, E; Lewis, KM; Vink, R | 2 |
| Chen, YW; Hung, CH; Lin, MF; Tzeng, JI; Wang, JJ | 1 |
| Boi, M; Carozzi, VA; Cavaletti, G; Chiorazzi, A; Del Fiacco, M; Dorsey, SG; Marmiroli, P; Melis, T; Meregalli, C; Picci, C; Poddighe, L; Quartu, M; Renn, CL; Serra, MP | 1 |
| Chen, CC; Chen, WN | 1 |
| Andersen, ML; Araujo, P; Frange, C; Hachul, H; Hirotsu, C; Tufik, S | 1 |
| Frallonardo, P; Lorenzin, MG; Oliviero, F; Ortolan, A; Punzi, L; Ramonda, R; Scanu, A | 1 |
| Banki, E; Bolcskei, K; Botz, B; Hajna, Z; Helyes, Z; Kemeny, A; Nagy, P; Reglodi, D; Toth, G | 1 |
| Cline, MA; Gilbert, ER; Guilliams, E; Mace, JD; Newmyer, BA; Tachibana, T; Wang, G | 1 |
| Ebihara, K; Funahashi, H; Ikeda, T; Ishida, Y; Koganemaru, G; Kuramashi, A; Naono-Nakayama, R; Nishimori, T | 1 |
| Hirose, Y; Kanagawa, E; Mikuriya, T; Shimogori, H; Sugahara, K; Yamashita, H | 1 |
| Fisher, A; Ratti, E; Trower, MK; Upton, N | 1 |
| Condjella, RM; Conley, O; Dahl, MV; Fryer, AD; Jacoby, DB; Jacoby, NW; Kloeber, JA; Lee, JJ; Lee, NA; Luo, H; Maizer, P; Mazzolini, A; Neely, JL; Ochkur, SI; Patel, YS; Protheroe, CA; Raish, RJ; Scott, GD; Vega, ML; Zellner, KR | 1 |
| Arruebo, MP; Gonzalo, S; Grasa, L; Martínez de Salinas, F; Murillo, MD; Plaza, MÁ; Valero, MS; Vergara, C | 1 |
| Beumer, JH; Dienel, S; Eiseman, JL; Horn, CC; Meyers, K; Rigatti, LH; Strychor, S | 1 |
| Choi, TH; Hur, W; Jung, Y; Kim, BK; Kim, JE; Kim, S; Kim, SH; Min, HJ; Min, HS | 1 |
| Ikeda, J; Ishihara, M; Kojima, N; Saeki, K; Takayama, M | 1 |
| Dong, YL; Li, YQ; Lu, YC; Wang, J; Wang, W; Wei, YY; Wu, HH; Wu, SX; Yin, JB; Zhang, T; Zhang, Y | 1 |
| Chen, DF; Fan, XH; Fu, WQ; Guo, LL; Murao, K; Shang, J; Wang, L; Wang, LH; Zhang, GX | 1 |
| Daschil, N; Humpel, C; Hutter-Paier, B; Kniewallner, KM; Marksteiner, J; Obermair, GJ; Windisch, M | 1 |
| Gao, T; Hökfelt, T; Shi, T; Su, J; Svensson, CI; Wiesenfeld-Hallin, Z; Xiang, Q; Xu, X | 1 |
| Inui, M; Nishida, T; Nomizu, M | 1 |
| Bettelini, L; Corsi, M; Costantini, VJ; Dünstl, G; Gerrard, P; Zonzini, L | 1 |
| Hou, W; Liu, H; Yang, X | 1 |
| Demir, N; Erin, N; Kale, Ş; Köksoy, S; Korcum, AF; Tanrıöver, G | 1 |
| Bhatia, M | 1 |
| Collier, TJ; Gebremedhin, KG; O'Malley, J; Paumier, KL; Rademacher, DJ; Sisson, KA; Sortwell, CE; Stancati, JA; Steece-Collier, K | 1 |
| Chen, B; Cheng, YW; Kong, LJ; Lin, X; Pang, J; Shi, YY; Zhan, HS | 1 |
| Chen, K; Liao, MF; Wang, J; Wang, XR; Yao, WL; Zhang, ZF | 1 |
| Dijkstra, JF; Duraku, LS; Holstege, JC; Schüttenhelm, BN; Walbeehm, ET | 1 |
| Herrity, AN; Hubscher, CH; Petruska, JC; Rau, KK; Stirling, DP | 1 |
| Brolin, E; Fransson, R; Hallberg, M; Haramaki, Y; Jonsson, A; Nordvall, G; Nyberg, F; Sandström, A; Skogh, A; Watanabe, H | 1 |
| Jiang, YN; Jin, RR; Lin, Q; Lu, CT; Mao, KL; Tian, FR; Yu, WZ; Zhao, YP; Zhao, YZ | 1 |
| Kuang, HX; Wang, JW; Yin, Y; Zhao, WJ; Zhao, XY; Zhong, L | 1 |
| Tang, K; Zhou, B; Zhou, Y | 1 |
| Clark, DJ; Guo, TZ; Kingery, WS; Li, WW; Shi, X; Wei, T | 1 |
| Daniel, M; Gonzalez, EJ; Kosofsky, M; Lambert, D; Malley, S; Peterson, A; Vizzard, MA | 1 |
| Chadi, G; Ferreira, LM; Hochman, B; Lapin, GA; Maximino, JR; Nishioka, MA | 1 |
| Altier, C; Basso, L; Chapman, K; Dietrich, G; Flynn, R; Iftinca, MC; Lapointe, TK; Vergnolle, N | 1 |
| Huang, Y; Lai, W; Liu, XS; Mao, RX; Qi, SH; Shu, B; Xie, JL; Xu, YB | 1 |
| Jia, MM; Leng, CL; Li, XJ; Li, YS; Tang, HB; Xi, Y; Zhang, WK | 1 |
| Chabot-Doré, AJ; Devost, D; Diatchenko, L; Fairbanks, CA; Hébert, TE; Millecamps, M; Naso, L; Piltonen, M; Stone, LS; Trieu, P; Wilcox, GL | 1 |
| Clark, DJ; Guo, TZ; Kingery, WS; Li, WW; Shi, X; Sun, Y; Wei, T | 1 |
| Jeon, SJ; Jung, Y; Kim, JE; Kim, SH; Kim, SJ | 1 |
| Bignami, F; Ferrari, G; Rama, P | 1 |
| Cho, SK; Hecht, AC; Iatridis, JC; Lai, A; Laudier, DM; Moon, A; Purmessur, D; Skovrlj, B; Winkelstein, BA | 1 |
| Chin, S; Cho, Y; Choi, S; Jung, N; Park, KS; Um, J | 1 |
| Hamity, MV; Hammond, DL; Li, Y; Maduka, UP; Walder, RY; White, SR | 1 |
| Clark, JD; Guo, TZ; Kingery, WS; Li, WW; Wei, T | 1 |
| Hong, HS; Kim, S; Park, JH; Son, Y | 1 |
| Jung, KM; Jung, Y; Kim, JE; Kim, SH | 1 |
| Jin, RR; Lin, Q; Lu, CT; Lv, CZ; Mao, KL; Tian, FR; Wáng, YX; Xiang, Q; Yang, W; Yu, WZ; Zhao, YZ | 1 |
| Antonioli, L; Bernardini, N; Blandini, F; Blandizzi, C; Cerri, S; Colucci, R; Cseri, K; Fornai, M; Haskó, G; Ippolito, C; Levandis, G; Pellegrini, C; Segnani, C; Tirotta, E | 1 |
| Chen, F; Ji, J; Xie, G; Xu, S; Zhang, Y; Zhu, F | 1 |
| Dyuizen, IV; Kasyanov, SP; Kipryushina, YO; Latyshev, NA; Manzhulo, IV; Ogurtsova, OS; Tyrtyshnaia, AA | 1 |
| Hoheisel, U; Mense, S | 1 |
| Chen, L; Han, LR; Li, H; Liu, HJ; Yan, H; Yan, J; Yang, XF | 1 |
| Chiswick, EL; Duffy, ER; Hsieh, T; Kim, J; Lussier, BL; Remick, DG; Stein, TD; Stepien, DM; Vaickus, MH | 1 |
| Huang, L; Huang, R; Koleini, M; Tang, Q; Wang, Y; Zhu, L; Zou, D | 1 |
| Chen, J; Ding, Y; Hu, K; Liu, W; Sun, C; Zhang, L; Zhao, J | 1 |
| Appleyard, CB; Cruz, ML; Hernandez, S; Seguinot, II; Torres-Reveron, A | 1 |
| Fan, X; Liu, H; Wang, N; Yu, J; Zhang, Y | 1 |
| Abdul, AM; Ackermann, PW; Ahmed, AS; Ahmed, M; Hart, DA; Hewitt, C; Li, J; Östenson, CG; Salo, PT | 1 |
| He, S; Jiang, Q; Wang, J; Wang, Z; Zhan, M; Zhang, H; Zhao, Z; Zheng, W | 1 |
| Arrigoni-Blank, MF; Barreto, PA; Brito, RG; Camargo, ZT; Kolker, SJ; Lucca-Júnior, W; Quintans, JSS; Quintans-Júnior, LJ; Santos, PL; Scotti, L; Scotti, MT; Sluka, KA | 1 |
| Alpini, G; Bernuzzi, F; Francis, H; Glaser, S; Glaser, T; Huang, Q; Invernizzi, P; Kennedy, L; Meng, F; Venter, J; Wan, Y; Wu, N; Zhou, T | 1 |
| Al-Shatti, T; Amin, M; Barbe, MF; Barr, AE; Elliott, MB; Kietrys, DM | 1 |
| Bhatia, M; Lu, J; Moochhala, S; Puthia, MK; Sio, SW | 1 |
| Kamei, C; Kuyama, S; Ogawa, M; Yokota, E | 1 |
| Aizawa, N; Imamura, T; Ishizuka, O; Nakayama, T; Nishizawa, O; Ogawa, T; Tanabe, T; Zhong, C | 1 |
| D'Souza, M; Garza, A; Martin, P; Mastrangelo, MA; Robinson, P; Tweardy, D | 1 |
| Antunes, E; Camargo, EA; de Nucci, G; Ferreira, T; Landucci, EC; Ribela, MT | 1 |
| Bartolomucci, A; Ciotti, MT; D'Amato, F; La Corte, G; Levi, A; Moles, A; Pavone, F; Possenti, R; Rizzi, R; Sacerdote, P | 1 |
| Bianchi, R; Caruso, D; Giatti, S; Gotti, S; Melcangi, RC; Panzica, GC; Pesaresi, M; Roglio, I; Scurati, S | 1 |
| Guo, Z; Meng, XX; Xie, LS; Yang, JH | 1 |
| Aita, M; Chavkin, C; Xu, M | 1 |
| Chen, CC; Hsieh, ST; Hsieh, YL; Tseng, TJ | 2 |
| Fujii, M; Kohno, S; Mizutani, N; Nabe, T; Nagasawa, M; Ohtani, Y; Tsuzuike, N; Watanabe, S; Yoshimura, M | 1 |
| Kumar, GK; Lee, MS; Prabhakar, NR; Raghuraman, G; Sharma, SD | 1 |
| Li, YS; Morioka, N; Nakata, Y; Ogata, N; Shiba, E; Tang, HB; Zheng, TX | 1 |
| Christianson, CA; Hua, XY; Nazarian, A; Yaksh, TL | 1 |
| Dolber, PC; Douglas, KL; Eldaif, BM; Fraser, MO; Jin, H; Nassar, R; Zhang, X | 1 |
| Aloe, L; Manni, L | 1 |
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| Berenshtein, E; Chevion, M; Goldin, E; Hershcovici, T; Israeli, E; Weiss, O; Wengrower, D; Zannineli, G | 1 |
| Altier, C; Castiglioni, AJ; Chapman, K; Dale, CS; Dickenson, AH; Evans, RM; Kisilevsky, AE; Lipscombe, D; Matthews, EA; Vergnolle, N; Zamponi, GW | 1 |
| Jesse, CR; Nogueira, CW; Pinto, LG; Rocha, JB; Savegnago, L; Zeni, G | 1 |
| Aarons, CB; Becker, JM; Gower, AC; Heydrick, SJ; Prushik, S; Reed, KL; Stucchi, AF | 1 |
| Busso, N; Grouzmann, E; Lacroix, JS; Landis, BN; Monod, M; Morel, DR; Petak, F; Robert, JH; Spiliopoulos, A; Szalay-Quinodoz, I | 1 |
| Arck, PC; Dinh, QT; Fischer, T; Handjiski, B; Joachim, RA; Klapp, BF; Kuhlmei, A; Paus, R; Peters, EM | 1 |
| Banerjee, B; Bansal, N; Lazarova, Z; Medda, BK; Sengupta, JN; Shaker, R | 1 |
| Finke, B; Gierer, P; Gradl, G; Mittlmeier, T; Schattner, S; Vollmar, B | 1 |
| Fröde, TS; Goulart, S; Lang, KL; Liz, R; Moritz, MI; Schenkel, EP | 1 |
| Kawana, S; Yamaoka, J | 1 |
| Gao, NR; Shi, X; Su, SZ | 1 |
| Ding, X; Mountain, DJ; Singh, K; Subramanian, V; Williams, CA | 1 |
| Eriksson, EM; Fowler, CJ; Furness, JB; Matsuyama, H; Nguyen, TV; Poole, DP | 1 |
| Benraiss, A; Chmielnicki, E; Cho, SR; Economides, A; Goldman, SA; Samdani, A | 1 |
| Das, P; Dong, W; Ji, Y; Miksa, M; Ravikumar, TS; Wang, P; Wu, R; Yang, D; Zhang, F; Zhou, M | 1 |
| Forsgren, S; Grimsholm, O; Guo, Y; Ny, T; Rantapää-Dahlqvist, S | 1 |
| Chrousos, GP; Kalantaridou, SN; Zoumakis, E | 1 |
| Chen, Z; Hubbard, RD; Winkelstein, BA | 1 |
| Chen, L; Cui, QL; Yung, WH | 1 |
| Jang, JE; Jung, JS; Kwon, MS; Lee, JK; Park, SH; Seo, YJ; Shim, EJ; Suh, HW | 1 |
| D'Souza, M; Garza, MA; Robinson, P; Weinstock, J; Xiang, Q; Xie, M | 1 |
| Akiyama, H; Amano, H; Bienenstock, J | 1 |
| Asai, H; Ishii, T; Kiuchi, S; Nagasaki, M; Okamoto, M; Saito, A; Taniguchi, H; Watanabe, Y | 1 |
| Chiang, H; Hsieh, ST; Hsieh, YL; Tseng, TJ | 1 |
| Almeida, A; Baltazar, F; Castro, AG; Cruz, A; Lamas, N; Lima-Rodrigues, M; Milanezi, F; Nunes, R; Pedrosa, J; Reis, RM; Valle-Fernandes, A | 1 |
| Hama, A; Herzberg, U; Sagen, J | 1 |
| Büchler, MW; Eisold, S; Fonouni, H; Gebhard, MM; Gutt, CN; Hinz, U; Kashfi, A; Konstantinidis, L; Mehrabi, A; Mieth, M; Müller-Stich, BP; Schmidt, J | 1 |
| Bataille, F; Bleich, A; Capellino, S; Falk, W; Grum, F; Obermeier, F; Schölmerich, J; Straub, RH; Strauch, U | 1 |
| Asensio, E; Casals, L; Navarro, X; Puigdemasa, A; Udina, E; Vivó, M | 1 |
| Bowe, C; Carvalho, E; Espinoza, D; Karagiannides, I; Kokkotou, E; Pothoulakis, C; Torres, D; Tseng, YH | 1 |
| Messina, P; Ruggeri, A; Scardina, GA | 1 |
| Baba, H; Kobayashi, S; Kokubo, Y; Miyazaki, T; Mwaka, E; Nakajima, H; Nomura, E; Takeno, K; Uchida, K; Yayama, T | 1 |
| Andren, PE; Chergui, K; Svenningsson, P; Zhang, X | 1 |
| Abad, J; Darmani, NA; Ramirez, J; Ray, AP; Thrush, GR; Wang, Y | 1 |
| Agnati, L; Fuxe, K; Ganten, D; Hökfelt, T; Rascher, W; Unger, T | 1 |
| Eysselein, VE; Reinshagen, M | 1 |
| Godet, A; Heidger, PM; Winfield, HN | 1 |
| Davis, W; Eysselein, V; Mueller, K; Nast, C; Patel, A; Reinshagen, M; Sottili, M | 1 |
| Goettl, VM; Larson, AA | 1 |
| Dubner, R; Ruda, MA; Thomas, DA | 1 |
| Chang, LC; Kuo, SC; Raung, SL; Wang, JP | 1 |
| Chatani, K; Gebhart, GF; Kawakami, M; Meller, ST; Weinstein, JN | 1 |
| Ahmed, M; Bjurholm, A; Kreicbergs, A; Schultzberg, M; Theodorsson, E | 1 |
| Cornefjord, M; Farley, DB; Olmarker, K; Rydevik, B; Weinstein, JN | 1 |
| Braun, M; Hohlfeld, T; Kienbaum, P; Sarbia, M; Schrör, K; Weber, AA | 1 |
| Koedel, U; Kümpfel, T; Pfister, HW | 1 |
| Inoue, H; Koshihara, Y; Nagata, N | 2 |
| Okamura, T; Toda, N; Yoshida, K | 1 |
| Ikeda, H; Kitajiri, M; Kubo, N; Kumazawa, T; Sato, K | 1 |
| Colburn, RW; Coombs, DW; DeLeo, JA; Fromm, C; Twitchell, BB | 1 |
| Bordner, J; Bryce, DK; Drozda, SE; Jackson, ER; Longo, KP; Lowe, JA; McLean, S; Morrone, J; Snider, RM; Zorn, SH | 1 |
| Baranowski, AP; McMahon, S; Priestley, JV | 1 |
| Doerfler, DL; Sailstad, DM; Selgrade, M; Veronesi, B | 1 |
| Killingsworth, CR; Paulauskis, JD; Shore, SA | 1 |
| Fattah, D; Hofman, G; Nijkamp, FP; van Ark, I; Van Der Linde, HJ; Van Oosterhout, AJ | 1 |
| Alstergren, P; Appelgren, A; Appelgren, B; Carleson, J; Kopp, S; Lundeberg, T; Theodorsson, E | 1 |
| Nabeshima, T; Nitta, A | 1 |
| Baur, X; Marcynski, B; Marek, W; Potthast, JJ | 1 |
| Chegini, N; Humphreys-Beher, MG; Ishibashi, K; Maeda, N; Nakagawa, Y; Oxford, GE; Robinson, CP; Yamamoto, H; Zeng, T | 1 |
| Beck, JM; Byrd, PK; Goetzl, EJ; Ichikawa, S; Ingram, DA; Kaltreider, HB; Kishiyama, JL; Sreedharan, SP; Warnock, ML | 1 |
| Haker, E; Lundeberg, T; Theodorsson, E | 2 |
| Hargreaves, RJ; Hill, RG; Shepheard, SL; Williamson, DJ | 1 |
| Chen, CF; Chen, LW; Chien, CT; Wu, MS | 1 |
| Chang, FY; Chu, CJ; Hou, MC; Lee, FY; Lee, SD; Lin, HC; Tai, CC; Tsai, YT; Wang, SS; Wu, SL | 1 |
| Aubineau, P; Delépine, L | 1 |
| Carlsöö, B; Lidegran, M; Midvedt, T; Nilsson, L; Norlander, T; Rivero, C; Stierna, P | 1 |
| Brodin, E; Delander, GE; Fredholm, BB; Schött, E | 1 |
| Austin-Ritchie, T; Baker, S; Carraway, RE; Hollins, C; Luber-Narod, J; Malhotra, RK; Menon, M | 1 |
| Appelgren, A; Appelgren, B; Bileviciute, I; Carleson, J; Kogner, P; Kopp, S; Lundeberg, T; Theodorsson, E; Yousef, N | 1 |
| Finkelstein, JB; Friedman, M; Gozal, D; Graham, RM; Hoyle, GW; Nguyen, KP | 1 |
| Fujiwara, R; Izushi, K; Kamei, C; Ohishi, H; Sugimoto, Y; Takada, M; Yamaji, M | 1 |
| Didier, A; Igarashi, Y; Kaliner, MA; Kowalski, ML; Lundgren, JD | 1 |
| Khalil, Z; Nyberg, F; Sanderson, K | 1 |
| Gebhart, GF; Hayashi, N; Lee, HM; Meller, ST; Spratt, KF; Weinstein, JN | 1 |
| Agmo, A; Huston, JP; Schildein, S; Schwarting, RK | 1 |
| Nørholt, SE | 1 |
| Chitano, P; Fabbri, LM; Jovine, L; Lucchini, RE; Maestrelli, P; Mapp, CE; Miotto, D; Polak, J; Saetta, M; Springall, DR | 1 |
| Ruggieri, MR | 1 |
| Calixto, JB; Campos, MM; Cechinel Filho, V; Mendes, GL; Santos, AR; Tratsk, KS; Yunes, RA | 1 |
| Fan, DS; Liu, T; Yang, PC; Zhang, TY | 1 |
| Endoh, N; Ichinose, M; Kageyama, N; Mashito, Y; Miura, M; Ohuchi, Y; Shirato, K; Sugiura, H; Tomaki, M | 1 |
| Calixto, JB; Chakravarty, S; Creczynski-Pasa, TB; Kyle, DJ; Mavunkel, BJ; Saleh, TS; Vianna, RM | 1 |
| Guo, R; Masumoto, K; Nada, O; Suita, S; Taguchi, T; Yamanouchi, T | 1 |
| Bergdahl, A; Edvinsson, L; Hedner, T; Nilsson, T; Sun, XY; Valdemarsson, S | 1 |
| Iwamoto, T; Kohri, H; Noguchi, K; Ohara, M; Sato, S; Senba, E; Yasuda, T | 1 |
| Löfgren, O; Lundeberg, T; Qi, Y | 1 |
| Ouyang, A; Yu, O | 1 |
| Andersson, B; Gillquist, J; Messner, K; Räsänen, T; Wei, Y | 1 |
| Aloe, L; Angelucci, F; Fiore, M; Koch, T; Korf, J; Talamini, L | 1 |
| Gresch, PJ; Walker, PD | 1 |
| Bordelon, YM; Chesselet, MF | 1 |
| Brickell, KL; Faull, RL; Nicholson, LF; Waldvogel, HJ | 1 |
| Moore, KA; Undem, BJ; Weinreich, D | 1 |
| Baby, S; Nguyen, M; Raffa, RB; Tran, D | 1 |
| Carpenter, E; Chesselet, MF; Koppel, A; MacKenzie, L; Menalled, L; Zanjani, H; Zeitlin, S | 1 |
| Damier, P; Féger, J; Hirsch, EC; Tremblay, L | 1 |
| Kakihara, Y; Komatsu, K; Kuraishi, Y; Tohda, C | 1 |
| Albright, GM; Hosaka, M; Janz, R; Li, JL; Richardson, JA; Shelton, JM; Südhof, TC; Victor, RG; Zhang, W | 1 |
| Baldwin, RA; Katsumori, H; Liu, H; Mazarati, AM; Nehlig, A; Pereira de Vasconselos, A; Sankar, R; Shirasaka, Y; Thompson, KW; Wasterlain, CG | 1 |
| Andren, PE; Gunne, L; Svenningsson, P | 1 |
| Figueredo-Cardenas, G; Fusco, F; Meade, CA; Nowak, TS; Pulsinelli, WA; Reiner, A | 1 |
| Bauman, NM; Luschei, ES; Sandler, AD; Wang, D | 1 |
| Ahlman, H; Ahrén, B; Bernhardt, P; Forssell-Aronsson, E; Johanson, V; Karlsson, S; Kölby, L; Nilsson, O; Stenman, G; Wängberg, B; Wigander, A | 1 |
| Furuta, A; Iwaki, T; Nomura, H; Suzuki, SO | 1 |
| Bisby, MA; Ma, W | 1 |
| Lysle, DT; Nelson, CJ | 1 |
| Ebersberger, A | 1 |
| Chen, J; Zheng, JH | 1 |
| Dreshaj, IA; Ferkol, T; Haxhiu, MA; Kelley, TJ; Martin, RJ; Mhanna, MJ; van Heeckeren, AM | 1 |
| Boissonade, FM; Elcock, C; Robinson, PP | 1 |
| Conway, CM; Dirig, DM; Isakson, PC; Luo, ZD; Svensson, C; Yaksh, TL | 1 |
| Arai, Y; Asao, T; Hozumi, S; Kinemuchi, H; Kisara, K; Nakagawasai, O; Niijima, F; Tadano, T; Tan-No, K; Taniguchi, R; Yasuhara, H | 1 |
| Cheema, SS; Kilpatrick, TJ; Lopes, EC; Phan, S; Reardon, K | 1 |
| Steer, ML | 1 |
| Goss, AN; Tahmasebi-Sarvestani, A; Tedman, R | 1 |
| Choi, SS; Lee, JK; Suh, HW | 1 |
| Ando, M; Fujii, K; Hamamoto, J; Hirata, N; Iwagoe, H; Kawano, O; Kohrogi, H | 1 |
| Befort, K; Brenner, GJ; Ji, RR; Woolf, CJ | 1 |
| Bjorling, DE; Haak-Frendscho, M; Hammond, TG; Saban, MR; Saban, R; Steinberg, H; Tengowski, MW | 1 |
| Bette, M; Haake, M; Thon, A | 1 |
| Ando, N; Endoh, T; Honda, T; Kamei, J; Kawamura, K; Nagase, H; Okano, K; Tanaka, T; Togashi, Y; Umeuchi, H; Utsumi, J; Yoshizawa, Y | 1 |
| Cahill, CM; Coderre, TJ | 1 |
| Bray, RC; Erwin, WM; Salo, PT; Seeratten, RA | 1 |
| Chen, CF; Chien, CT; Huang, HS; Ma, MC; Wu, MS | 1 |
| Bellinger, DL; Felten, DL; Felten, SY; Lorton, D | 1 |
| Gebhart, GF; Maves, TJ; Meller, ST | 1 |
| Darley-Usmar, V; O'Leary, VJ; Payne, AN; Wilkinson, D; Yeadon, M | 1 |
| Selig, W; Tocker, J | 1 |
| Gibson, SJ; Hukkanen, M; Konttinen, YT; Polak, JM; Rees, RG; Santavirta, S | 1 |
| Banerjee, DK; Gibson, SJ; Kar, S; Karanth, SS; Polak, JM; Royston, JP; Springall, DR | 1 |
| Anderson, JA; Duzman, E; Hernandez, E; Malfroy, B | 1 |
| Cheung, A; Tang, F; Vacca-Galloway, LL | 1 |
| Doyle, PT; Ferguson, DR; Harrison, SC | 1 |
| Bennett, JP; Orosz, D | 1 |
| Brewerton, DA; Gibson, SJ; Grönblad, M; Hukkanen, M; Konttinen, YT; Polak, JM; Rees, R; Tolvanen, E | 1 |
| Beal, MF; Ferrante, RJ; Kowall, NW; Swartz, KJ | 1 |
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| Gunne, L; Häggström, JE; Johansson, PE; Terenius, L | 1 |
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| Allen, JM; Close, SP; Cross, AJ; Crow, TJ; Ghatei, MA; Marriott, AS; McGregor, GP; Pay, S; Tyers, MB; Yeats, JC | 1 |
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| Handa, H; Mizuno, N; Okamoto, S; Sugimoto, T; Uemura, Y | 1 |
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| Beal, MF; Ferrante, RJ; Kowall, NW; Martin, JB; Swartz, KJ | 1 |
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26 review(s) available for substance p and Disease Models, Animal
| Article | Year |
|---|---|
Research Progress on the Mechanism of Acupuncture in the Prevention and Treatment of Allergic Rhinitis.
Topics: Acupuncture Therapy; Animals; Disease Models, Animal; Humans; Immunoglobulin E; Nasal Mucosa; Rhinitis, Allergic; Substance P | 2023 |
Gastrointestinal neuroendocrine peptides/amines in inflammatory bowel disease.
Topics: Amines; Animals; Chromogranins; Disease Models, Animal; Gastrointestinal Microbiome; Gastrointestinal Tract; Ghrelin; Humans; Inflammatory Bowel Diseases; Neuroendocrine Cells; Neuropeptide Y; Neurosecretory Systems; Prevalence; Quality of Life; Recurrence; Serotonin; Serotonin Antagonists; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 2017 |
Substance P and neurokinin 1 receptor are new targets for the treatment of chronic pruritus.
Topics: Animals; Chronic Disease; Clinical Trials, Phase II as Topic; Disease Models, Animal; Humans; Molecular Targeted Therapy; Neurokinin-1 Receptor Antagonists; Pruritus; Quality of Life; Receptors, Neurokinin-1; Severity of Illness Index; Signal Transduction; Skin; Substance P; Treatment Outcome | 2019 |
Substance P antagonists as a novel intervention for brain edema and raised intracranial pressure.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; Disease Models, Animal; Humans; Intracranial Hypertension; Receptors, Tachykinin; Substance P; Time Factors | 2013 |
Fibromyalgia and sleep in animal models: a current overview and future directions.
Topics: Animals; Chronic Pain; Disease Models, Animal; Evidence-Based Medicine; Fatigue; Fibromyalgia; Humans; Pain Threshold; Rats; Serotonin; Severity of Illness Index; Sleep; Sleep Wake Disorders; Substance P | 2014 |
Pain and microcrystalline arthritis.
Topics: Animals; Arthritis, Gouty; Calcium Pyrophosphate; Chronic Pain; Crystallization; Dinoprostone; Disease Models, Animal; Humans; Inflammation Mediators; Interleukin-1beta; Kinins; Musculoskeletal Pain; Nociceptors; Osteoarthritis; Quality of Life; Rats; Substance P; TRPV Cation Channels; Uric Acid | 2014 |
Peptide therapies for ocular surface disturbances based on fibronectin-integrin interactions.
Topics: Animals; Corneal Diseases; Disease Models, Animal; Epithelium, Corneal; Fibronectins; Humans; Insulin-Like Growth Factor I; Integrins; Molecular Targeted Therapy; Peptides; Substance P; Wound Healing | 2015 |
H₂S and substance P in inflammation.
Topics: Acute Disease; Animals; Burns; Carrageenan; Ceruletide; Disease Models, Animal; Drug Synergism; Edema; Endotoxemia; Hydrogen Sulfide; Lipopolysaccharides; Lung Injury; Mice; Pancreatitis; Substance P | 2015 |
Substance P and its Inhibition in Ocular Inflammation.
Topics: Animals; Disease Models, Animal; Eye Diseases; Humans; Inflammation; Neuropeptides; Receptors, Neurokinin-1; Substance P | 2016 |
Neurotrophic keratopathy; its pathophysiology and treatment.
Topics: Animals; Cell Movement; Cell Survival; Cornea; Corneal Diseases; Disease Models, Animal; Epithelium, Corneal; Gene Expression Regulation; Humans; Signal Transduction; Substance P; Trigeminal Nerve; Trigeminal Nerve Injuries; TRPC Cation Channels; Wound Healing | 2010 |
[Neuropeptide effects on the trigeminal system: pathophysiology and clinical significance for migraine].
Topics: Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Cluster Headache; Disease Models, Animal; Humans; Migraine Disorders; Nociceptors; Rats; Receptors, Calcitonin Gene-Related Peptide; Signal Transduction; Substance P; Synaptic Transmission; Trigeminal Ganglion; Trigeminal Nerve; Trigeminal Nucleus, Spinal; Vasoactive Intestinal Peptide | 2011 |
Role of sensory nervous system vasoactive peptides in hypertension.
Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Cells, Cultured; Desoxycorticosterone; Disease Models, Animal; Female; Hypertension; Mice; Mice, Knockout; Neurons, Afferent; NG-Nitroarginine Methyl Ester; Pregnancy; Rats; Rats, Inbred SHR; Sensory Receptor Cells; Substance P | 2002 |
Contribution of neuroimmune mechanisms to airway inflammation and remodeling during and after respiratory syncytial virus infection.
Topics: Animals; Asthma; Capillary Permeability; Child; Child, Preschool; Disease Models, Animal; Humans; Infant; Infant, Newborn; Lung; Muscle, Smooth; Nerve Growth Factors; Neuronal Plasticity; Pneumonia; Rats; Receptors, Neurokinin-1; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus, Human; Risk Factors; Substance P; T-Lymphocytes | 2003 |
Substance P antagonists: meet the new drugs, same as the old drugs? Insights from transgenic animal models.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety Disorders; Brain; Clinical Trials as Topic; Depressive Disorder; Disease Models, Animal; Drug Evaluation, Preclinical; Drugs, Investigational; Humans; Mice; Mice, Transgenic; Receptors, Neurokinin-1; Substance P | 2003 |
Contribution of respiratory syncytial virus G antigenicity to vaccine-enhanced illness and the implications for severe disease during primary respiratory syncytial virus infection.
Topics: Animals; Antigens, Viral; Disease Models, Animal; Epitopes; Female; Glycoproteins; Immunity; Immunization; Interleukin-4; Interleukin-8; Male; Mice; Mice, Inbred BALB C; Pulmonary Eosinophilia; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Sensitivity and Specificity; Severity of Illness Index; Substance P; Viral Vaccines | 2004 |
Mutant mouse models of depression: candidate genes and current mouse lines.
Topics: Animals; Biogenic Monoamines; Depression; Disease Models, Animal; Humans; Hypothalamo-Hypophyseal System; Interleukins; Mice; Mice, Mutant Strains; Models, Neurological; Nerve Growth Factors; Neuropeptide Y; Pituitary-Adrenal System; Receptors, Neurokinin-1; Substance P | 2005 |
Extending the understanding of sensory neuropeptides.
Topics: Animals; Asthma; Bronchoconstriction; Clinical Trials as Topic; Disease Models, Animal; Humans; Neurokinin A; Neurons, Afferent; Neurotransmitter Agents; Pulmonary Disease, Chronic Obstructive; Receptors, Tachykinin; Respiratory System; Respiratory System Agents; Substance P | 2006 |
[Importance of epidermal keratinocytes in itching].
Topics: Animals; Disease Models, Animal; Drug Design; Epidermal Cells; Histamine Release; Humans; Keratinocytes; Leukotriene B4; Mast Cells; Mice; Nitric Oxide; Pruritus; Receptor, PAR-2; Substance P | 2006 |
[Neurologic inflammation and oral disease. An aetiopathogenic hypothesis].
Topics: Animals; Disease Models, Animal; Disease Progression; Humans; Microcirculation; Mouth Diseases; Mouth Mucosa; Neurogenic Inflammation; Neuropeptides; Nociceptors; Pain; Rats; Substance P; Swine; Tongue; Vasoactive Intestinal Peptide | 2007 |
Peptidergic and catecholaminergic mechanisms in central blood pressure control.
Topics: Angiotensin II; Animals; Blood Pressure; Brain; Catecholamines; Disease Models, Animal; Epinephrine; Humans; Hypertension; Kinins; Neurotransmitter Agents; Norepinephrine; Peptides; Pressoreceptors; Rats; Substance P | 1980 |
[Sensory neuropeptides: pro-inflammatory or protective effect in the intestine?].
Topics: Acute-Phase Reaction; Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Enteritis; Humans; Neuropeptides; Nociceptors; Rabbits; Rats; Sensory Receptor Cells; Substance P | 1993 |
Discovery of CP-96,345 and its characterization in disease models involving substance P.
Topics: Analgesics; Animals; Asthma; Binding, Competitive; Biphenyl Compounds; Disease Models, Animal; Inflammation; Pain; Receptors, Neurokinin-2; Substance P | 1993 |
Treatment of acute pain following removal of mandibular third molars. Use of the dental pain model in pharmacological research and development of a comparable animal model.
Topics: Acute Disease; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bite Force; Calcitonin Gene-Related Peptide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation; Humans; Mandible; Molar, Third; Morphine; Movement; Neuropeptides; Pain Threshold; Pain, Postoperative; Piroxicam; Rats; Substance P; Tooth Extraction | 1998 |
Substance P antagonists: the next breakthrough in treating depression?
Topics: Animals; Antidepressive Agents; Clinical Trials as Topic; Depression; Disease Models, Animal; Forecasting; Humans; Receptors, Neurokinin-1; Substance P | 1999 |
[Development of dyskinesias induced by treatment for Parkinson's disease: potential role of first exposure to L-DOPA (or phenomenon of priming)].
Topics: Animals; Antiparkinson Agents; Biological Transport, Active; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; Enkephalins; Haplorhini; Humans; Levodopa; Neural Pathways; Neuronal Plasticity; Neurons, Efferent; Parkinson Disease; Receptors, Dopamine D2; Substance P; Time Factors | 2000 |
Physiology of meningeal innervation: aspects and consequences of chemosensitivity of meningeal nociceptors.
Topics: Afferent Pathways; Animals; Bradykinin; Calcitonin Gene-Related Peptide; Dinoprostone; Disease Models, Animal; Headache; Humans; Meninges; Neurokinin A; Neuropeptides; Nociceptors; Prostaglandins; Substance P | 2001 |
561 other study(ies) available for substance p and Disease Models, Animal
| Article | Year |
|---|---|
Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions.
Topics: Animals; Disease Models, Animal; Drug Hypersensitivity; Female; HEK293 Cells; Histamine Release; Humans; Inflammation; Male; Mast Cells; Mice; Mice, Knockout; Nerve Tissue Proteins; Receptors, G-Protein-Coupled; Receptors, Neuropeptide | 2015 |
Ultra-Low Frequency Transcutaneous Electrical Nerve Stimulation on Pain Modulation in a Rat Model with Myogenous Temporomandibular Dysfunction.
Topics: Animals; Chronic Pain; Disease Models, Animal; Electromyography; Electrophysiological Phenomena; Masticatory Muscles; Motor Endplate; Myofascial Pain Syndromes; Parabrachial Nucleus; Proto-Oncogene Proteins c-fos; Rats; Receptors, Opioid, mu; Substance P; Temporomandibular Joint Disorders; Transcutaneous Electric Nerve Stimulation | 2021 |
Possible therapeutic effect of royal jelly on endometriotic lesion size, pain sensitivity, and neurotrophic factors in a rat model of endometriosis.
Topics: Animals; Ascitic Fluid; Brain-Derived Neurotrophic Factor; Calcitonin Gene-Related Peptide; Disease Models, Animal; Endometriosis; Fatty Acids; Female; Ganglia, Spinal; Nerve Growth Factor; Nerve Growth Factors; Pain Measurement; Rats; Substance P | 2021 |
Analgesic effects of a 5-HT3 receptor antagonist in an animal model of complex regional pain syndrome.
Topics: Analgesics; Animals; Benzimidazoles; Brain Stem; Complex Regional Pain Syndromes; Cytokines; Disease Models, Animal; Pain; Rats, Sprague-Dawley; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Antagonists; Substance P; Tibial Fractures | 2021 |
Therapeutic effect of targeting Substance P on the progression of osteoarthritis.
Topics: Animals; Aprepitant; Cartilage, Articular; Disease Models, Animal; Humans; Mice; Osteoarthritis; Phosphates; Substance P; X-Ray Microtomography | 2022 |
Terrestrosin D ameliorates skin lesions in an imiquimod-induced psoriasis-like murine model by inhibiting the interaction between Substance P and Dendritic cells.
Topics: Animals; Cell Proliferation; Cytokines; Dendritic Cells; Disease Models, Animal; Imiquimod; Mice; Mice, Inbred BALB C; Psoriasis; Saponins; Skin; Substance P | 2022 |
Pinocembrin relieves hip fracture-induced pain by repressing spinal substance P signaling in aged rats.
Topics: Aging; Animals; Disease Models, Animal; Flavanones; Hip Fractures; Indoles; Male; Neurokinin-1 Receptor Antagonists; Nociceptive Pain; Pain; Piperidines; Rats; Rats, Sprague-Dawley; Signal Transduction; Substance P | 2022 |
Artemisinic acid attenuated symptoms of substance P-induced chronic urticaria in a mice model and mast cell degranulation via Lyn/PLC-p38 signal pathway.
Topics: Anaphylaxis; Animals; Cell Degranulation; Chronic Urticaria; Disease Models, Animal; Mast Cells; Mice; NF-kappa B; Quality of Life; Signal Transduction; Substance P | 2022 |
The Role of Substance P Receptor Antagonists in Allergic Rhinitis: Ovalbumin-Induced Rat Model.
Topics: Animals; Aprepitant; Disease Models, Animal; Female; Histamine Antagonists; Nasal Mucosa; Neurokinin-1 Receptor Antagonists; Ovalbumin; Rats; Rats, Sprague-Dawley; Rhinitis, Allergic; Substance P | 2023 |
Functional neuronal circuits promote disease progression in cancer.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Human Papillomavirus Viruses; Humans; Mice; Mice, Inbred C57BL; Neurons; Ovarian Neoplasms; Ovary; Specific Pathogen-Free Organisms; Squamous Cell Carcinoma of Head and Neck; Substance P; Survival Analysis | 2023 |
C7 peptide inhibits hepatocellular carcinoma metastasis by targeting the HGF/c-Met signaling pathway.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Galanin; Hepatocyte Growth Factor; Humans; Immunohistochemistry; Liver Neoplasms; Mice; Peptide Fragments; Peptide Library; Protein Binding; Proto-Oncogene Proteins c-met; Signal Transduction; Substance P; Xenograft Model Antitumor Assays | 2019 |
Modulatory effects of neuropeptides on pentylenetetrazol-induced epileptic seizures and neuroinflammation in rats.
Topics: Animals; Biomarkers; Calcitonin Gene-Related Peptide; Convulsants; Disease Models, Animal; Ghrelin; Inflammation; Interleukin-1beta; Male; Myoclonus; Neuropeptides; Pentylenetetrazole; Peptide Hormones; Random Allocation; Rats, Wistar; Seizures; Substance P; Time Factors; Vasoactive Intestinal Peptide | 2019 |
Vincristine increased spinal cord substance P levels in a peripheral neuropathy rat model.
Topics: Animals; Disease Models, Animal; Humans; Neuralgia; Quality of Life; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Vincristine | 2022 |
Pulsed radiofrequency alleviated neuropathic pain by down-regulating the expression of substance P in chronic constriction injury rat model.
Topics: Animals; Constriction, Pathologic; Disease Models, Animal; Hyperalgesia; Male; Neuralgia; Pulsed Radiofrequency Treatment; Rats; Rats, Sprague-Dawley; Substance P | 2020 |
Morphine-3-glucuronide causes antinociceptive cross-tolerance to morphine and increases spinal substance P expression.
Topics: Animals; Central Nervous System Stimulants; Disease Models, Animal; Drug Administration Schedule; Drug Tolerance; Humans; Hyperalgesia; Injections, Spinal; Male; Morphine; Morphine Derivatives; Nociception; Pain Measurement; Rats; Spinal Cord; Substance P | 2020 |
Alcohol dependence potentiates substance P/neurokinin-1 receptor signaling in the rat central nucleus of amygdala.
Topics: Adaptation, Physiological; Alcoholism; Animals; Central Amygdaloid Nucleus; Disease Models, Animal; Disease Susceptibility; gamma-Aminobutyric Acid; Gene Expression; Immunohistochemistry; Male; Rats; Receptors, Neurokinin-1; Signal Transduction; Substance P; Substance Withdrawal Syndrome | 2020 |
HMGB1 and its membrane receptors as therapeutic targets in an intravesical substance P-induced bladder pain syndrome mouse model.
Topics: Animals; Antibodies, Neutralizing; Cystitis, Interstitial; Disease Models, Animal; Female; HMGB1 Protein; Humans; Male; Mice, Inbred Strains; Molecular Targeted Therapy; Receptor for Advanced Glycation End Products; Receptors, CXCR4; Receptors, Cytoplasmic and Nuclear; Substance P; Thrombomodulin | 2020 |
Corneal Nerve Ablation Abolishes Ocular Immune Privilege by Downregulating CD103 on T Regulatory Cells.
Topics: Animals; Anterior Chamber; Antigens, CD; Cells, Cultured; Cornea; Corneal Transplantation; Disease Models, Animal; Graft Rejection; Graft Survival; Immune Privilege; Immune Tolerance; Integrin alpha Chains; Interferon-gamma; Laser Therapy; Mice; Mice, Inbred BALB C; Substance P; T-Lymphocytes, Regulatory | 2020 |
Renin-angiotensin system blockade modulates both the peripheral and central components of neuropathic pain in rats: Role of calcitonin gene-related peptide, substance P and nitric oxide.
Topics: Analgesics; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Brain; Calcitonin Gene-Related Peptide; Disease Models, Animal; Male; Nitric Oxide; Pain Threshold; Rats; Renin-Angiotensin System; Sciatic Nerve; Sciatic Neuropathy; Signal Transduction; Substance P | 2020 |
PAR2, Keratinocytes, and Cathepsin S Mediate the Sensory Effects of Ciguatoxins Responsible for Ciguatera Poisoning.
Topics: Animals; Calcium; Cathepsins; Ciguatera Poisoning; Ciguatoxins; Coculture Techniques; Cytosol; Disease Models, Animal; Epidermis; Humans; Intravital Microscopy; Keratinocytes; Paresthesia; Primary Cell Culture; Pruritus; Rats; Receptor, PAR-2; Sensory Receptor Cells; Single-Cell Analysis; Substance P | 2021 |
Ocular surface inflammation induces de novo expression of substance P in the trigeminal primary afferents with large cell bodies.
Topics: Animals; Apoptosis; Benzalkonium Compounds; Cell Body; Conjunctivitis; Disease Models, Animal; Epithelium, Corneal; Goblet Cells; Interleukin-1beta; Interleukin-6; Keratitis; Rats; Rats, Sprague-Dawley; Substance P; Trigeminal Ganglion; Tumor Necrosis Factor-alpha | 2020 |
Effect of Qinbai Qingfei Concentrated Pellets on substance P and neutral endopeptidase of rats with post-infectious cough.
Topics: Animals; Biomarkers; Cough; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Male; Neprilysin; Rats; Rats, Sprague-Dawley; Substance P | 2020 |
Substance P restores spermatogenesis in busulfan-treated mice: A new strategy for male infertility therapy.
Topics: Animals; Apoptosis; Azoospermia; Busulfan; Cell Line; Cell Proliferation; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Fertility; Fertility Agents, Male; Male; Mice, Inbred C57BL; Receptors, Neurokinin-1; Signal Transduction; Spermatogenesis; Spermatogonia; Substance P; Tissue Culture Techniques | 2021 |
The amino-terminal heptapeptide of the algesic substance P provides analgesic effect in relieving chronic neuropathic pain.
Topics: Amides; Analgesics; Analgesics, Opioid; Animals; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Mice, Inbred ICR; Neuralgia; Pain Threshold; Peptide Fragments; Receptors, Opioid, mu; Substance P | 2021 |
FcεR1-expressing nociceptors trigger allergic airway inflammation.
Topics: Allergens; Animals; Calcium; Disease Models, Animal; Disease Susceptibility; Gene Expression; Genetic Predisposition to Disease; Hypersensitivity; Mice; Mice, Knockout; Neurons; Nociceptors; Ovalbumin; Receptors, IgE; Respiratory Mucosa; Substance P; Vagus Nerve | 2021 |
Role of perivascular nerve and sensory neurotransmitter dysfunction in inflammatory bowel disease.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Female; Helicobacter hepaticus; Inflammatory Bowel Diseases; Interleukin-10; Male; Mesenteric Arteries; Mice, Inbred C57BL; Mice, Knockout; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Sensory Receptor Cells; Signal Transduction; Splanchnic Circulation; Substance P; Sympathetic Nervous System; Vasoconstriction; Vasodilation | 2021 |
Modulating Ocular Surface Pain Through Neurokinin-1 Receptor Blockade.
Topics: Administration, Ophthalmic; Animals; Cornea; Corneal Diseases; Disease Models, Animal; Eye Pain; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Neurokinin-1 Receptor Antagonists; Nociception; Ophthalmic Solutions; Substance P; Tears; Trigeminal Nerve | 2021 |
Angiotensin (1-7) Attenuates the Nociceptive Behavior Induced by Substance P and NMDA via Spinal MAS1.
Topics: Angiotensin I; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Injections, Spinal; Male; Mice; N-Methylaspartate; Nociception; Nociceptive Pain; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptors, G-Protein-Coupled; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Cord; Substance P | 2021 |
Substance P-induced lung inflammation in mice is mast cell dependent.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Humans; Lung; Mast Cells; Mice; Mice, Inbred C57BL; Pneumonia; Substance P | 2022 |
Increased expression of transient receptor potential channels and neurogenic factors associates with cough severity in a guinea pig model.
Topics: Animals; Bleomycin; Cough; Disease Models, Animal; Disease Progression; Guinea Pigs; Idiopathic Pulmonary Fibrosis; Lung; Male; Neurogenic Inflammation; Substance P; TRPA1 Cation Channel; TRPV Cation Channels | 2021 |
A role for substance P and acid-sensing ion channel 1a in prolotherapy with dextrose-mediated analgesia in a mouse model of chronic muscle pain.
Topics: Acid Sensing Ion Channels; Analgesia; Animals; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Fibromyalgia; Glucose; Hyperalgesia; Mice; Myalgia; Prolotherapy; Substance P | 2022 |
Mechanisms of nerve growth factor signaling in bone nociceptors and in an animal model of inflammatory bone pain.
Topics: Action Potentials; Animals; Antibodies; Bone and Bones; Calcitonin Gene-Related Peptide; Disease Models, Animal; Freund's Adjuvant; Male; NAV1.8 Voltage-Gated Sodium Channel; NAV1.9 Voltage-Gated Sodium Channel; Nerve Growth Factor; Nociceptors; Osteoarthritis; Pain; Rats; Rats, Sprague-Dawley; Signal Transduction; Substance P; TRPV Cation Channels; Ubiquitin Thiolesterase | 2017 |
Substance P accelerates wound healing in type 2 diabetic mice through endothelial progenitor cell mobilization and Yes-associated protein activation.
Topics: Adaptor Proteins, Signal Transducing; Animals; Bone Marrow; Cell Cycle Proteins; Cell Movement; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Endothelial Progenitor Cells; Immunohistochemistry; Injections, Subcutaneous; Male; Mice; Neovascularization, Physiologic; Phosphoproteins; Platelet Endothelial Cell Adhesion Molecule-1; Random Allocation; Substance P; Wound Healing; YAP-Signaling Proteins | 2017 |
A possible role for CD26/DPPIV enzyme activity in the regulation of psoriatic pruritus.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antipruritics; Behavior, Animal; Biomarkers; Case-Control Studies; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Female; Genetic Predisposition to Disease; Humans; Male; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Phenotype; Pruritus; Psoriasis; Substance P; Time Factors; Up-Regulation; Young Adult | 2017 |
PanIN Neuroendocrine Cells Promote Tumorigenesis via Neuronal Cross-talk.
Topics: 3T3 Cells; Animals; Carcinogenesis; Carcinoma, Pancreatic Ductal; Disease Models, Animal; Ganglia, Spinal; HEK293 Cells; Humans; Mice; Mice, Inbred C57BL; Neuroendocrine Cells; Pancreas; Pancreatic Neoplasms; Precancerous Conditions; Sensory Receptor Cells; STAT3 Transcription Factor; Substance P | 2017 |
Effects of a combination treatment of KD5040 and
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Dopamine and cAMP-Regulated Phosphoprotein 32; Dyskinesia, Drug-Induced; Enkephalins; Extracellular Signal-Regulated MAP Kinases; Levodopa; Magnoliopsida; Male; Mice, Inbred C57BL; Movement; Parkinson Disease; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-fos; Substance P | 2017 |
Spinal neuropeptide modulation, functional assessment and cartilage lesions in a monosodium iodoacetate rat model of osteoarthritis.
Topics: Animals; Bradykinin; Calcitonin Gene-Related Peptide; Cartilage Diseases; Disease Models, Animal; Female; Iodoacetic Acid; Neuropeptides; Nociception; Osteoarthritis; Pain Threshold; Rats, Sprague-Dawley; Somatostatin; Spinal Cord; Stifle; Substance P | 2017 |
A Comprehensive Method To Quantify Adaptations by Male and Female Mice With Hot Flashes Induced by the Neurokinin B Receptor Agonist Senktide.
Topics: Adaptation, Physiological; Animals; Behavior, Animal; Body Temperature; Capsaicin; Disease Models, Animal; Female; Hot Flashes; Hot Temperature; Male; Mice; Mice, Inbred C57BL; Peptide Fragments; Preoptic Area; Proto-Oncogene Proteins c-fos; Receptors, Neurokinin-3; Skin Temperature; Substance P | 2017 |
Intra-articular injection of a substance P inhibitor affects gene expression in a joint contracture model.
Topics: Animals; Biomechanical Phenomena; Contracture; Disease Models, Animal; Elbow Injuries; Elbow Joint; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Humans; Injections; Morpholines; Oligonucleotide Array Sequence Analysis; Rabbits; Substance P | 2018 |
Topics: Acute Disease; Animals; Arachidonic Acids; Calcitonin Gene-Related Peptide; Disease Models, Animal; Dopamine; Inflammation; Lipopeptides; Lipopolysaccharides; Mice; Plasminogen Activator Inhibitor 1; Sepsis; Substance P; TRPV Cation Channels | 2017 |
Substance P preserves pancreatic β-cells in streptozotocin-induced type 1 diabetic mice.
Topics: Acute Disease; Animals; Apoptosis; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Insulin-Secreting Cells; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Pancreatitis; Streptozocin; Structure-Activity Relationship; Substance P | 2017 |
Altered circadian feeding behavior and improvement of metabolic syndrome in obese Tac1-deficient mice.
Topics: Animals; Circadian Rhythm; Disease Models, Animal; Energy Metabolism; Feeding Behavior; Metabolic Syndrome; Mice; Mice, Knockout; Mice, Obese; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Signal Transduction; Substance P; Tachykinins | 2017 |
The role of the transient receptor potential ankyrin type-1 (TRPA1) channel in migraine pain: evaluation in an animal model.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Hyperalgesia; Male; Migraine Disorders; Nitroglycerin; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Substance P; Trigeminal Caudal Nucleus; Trigeminal Ganglion; TRPA1 Cation Channel | 2017 |
Chronic social stress Ameliorates psoriasiform dermatitis through upregulation of the Hypothalamic-Pituitary-Adrenal axis.
Topics: Adrenal Cortex Hormones; Animals; Calcitonin Gene-Related Peptide; Corticosterone; Dermatitis; Disease Models, Animal; Ganglia, Spinal; Hypothalamo-Hypophyseal System; Male; Mice; Mice, Transgenic; Nerve Growth Factor; Neuropeptides; Pituitary-Adrenal System; Psoriasis; Receptors, Glucocorticoid; RNA, Messenger; Stress, Psychological; Substance P; Transcriptional Activation; Up-Regulation | 2018 |
Substance P Attenuates Hypoxia/Reoxygenation-Induced Apoptosis via the Akt Signalling Pathway and the NK1-Receptor in H9C2Cells.
Topics: Animals; Apoptosis; Blotting, Western; Cells, Cultured; Disease Models, Animal; Hypoxia; Immunohistochemistry; Myocardial Reperfusion Injury; Myocytes, Cardiac; Neurotransmitter Agents; Proto-Oncogene Proteins c-akt; Receptors, Neurokinin-1; Signal Transduction; Substance P | 2018 |
Estrogen Modulates Corneal Nociception and Maintains Corneal Homeostasis in Rat Eye.
Topics: Animals; Calcitonin Gene-Related Peptide; Cornea; Disease Models, Animal; Dry Eye Syndromes; Estrogens; Female; Lacrimal Apparatus; Nociception; Rats; Rats, Sprague-Dawley; Substance P; Tears; TRPV Cation Channels | 2018 |
TRPA1 channel participates in tacrolimus-induced pruritus in a chronic contact hypersensitivity murine model.
Topics: Administration, Cutaneous; Animals; Aprepitant; Behavior, Animal; Calcineurin Inhibitors; Dermatitis, Contact; Disease Models, Animal; Filaggrin Proteins; Ganglia, Spinal; Humans; Intermediate Filament Proteins; Male; Mice; Mice, Inbred BALB C; Mice, Transgenic; Ointments; Oxazolone; Oximes; Pruritus; Skin; Substance P; Tacrolimus; TRPA1 Cation Channel | 2018 |
MicroRNA-31-3p Is Involved in Substance P (SP)-Associated Inflammation in Human Colonic Epithelial Cells and Experimental Colitis.
Topics: Animals; Cell Line; Colitis; Colon; Crohn Disease; Dextran Sulfate; Disease Models, Animal; Epithelial Cells; Humans; Inflammation; MAP Kinase Signaling System; Mice; MicroRNAs; Substance P | 2018 |
The research of the possible mechanism and the treatment for capsaicin-induced cough.
Topics: Animals; Antitussive Agents; Calcitonin Gene-Related Peptide; Capsaicin; Chronic Disease; Codeine; Cough; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Guinea Pigs; Male; Neurokinin A; Pyrrolidines; Substance P; TRPV Cation Channels; Urea | 2018 |
Substance P prevents development of proliferative vitreoretinopathy in mice by modulating TNF-α.
Topics: Actins; Animals; Apoptosis; Blotting, Western; Cell Movement; Cell Transdifferentiation; Cells, Cultured; Cytokines; Disease Models, Animal; Epithelial-Mesenchymal Transition; Humans; Male; Mice; Mice, Inbred C57BL; Neurotransmitter Agents; Retinal Pigment Epithelium; Substance P; Tumor Necrosis Factor-alpha; Vitreoretinopathy, Proliferative | 2017 |
The anti-inflammatory action of maropitant in a mouse model of acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Neurokinin-1 Receptor Antagonists; Pancreatitis; Peroxidase; Quinuclidines; Receptors, Neurokinin-1; Substance P | 2018 |
Antinociceptive profiles and mechanisms of centrally administered oxyntomodulin in various mouse pain models.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Cytokines; Disease Models, Animal; Formaldehyde; Glutamic Acid; Injections, Intraventricular; Injections, Spinal; Male; Mice, Inbred ICR; Nociception; Oxyntomodulin; Pain; Rotarod Performance Test; Spinal Cord; Substance P | 2018 |
Transient Receptor Potential Ankyrin 1 and Substance P Mediate the Development of Gastric Mucosal Lesions in a Water Immersion Restraint Stress Rat Model.
Topics: Acetanilides; Animals; Disease Models, Animal; Ganglia, Spinal; Gastric Mucosa; Humans; Isothiocyanates; Male; Neurons; Purines; Rats; Rats, Wistar; Stomach Ulcer; Stress, Psychological; Substance P; TRPA1 Cation Channel | 2018 |
Transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 contribute to the progression of colonic inflammation in dextran sulfate sodium-induced colitis in mice: Links to calcitonin gene-related peptide and substance P.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Colitis; Dextran Sulfate; Disease Models, Animal; Disease Progression; Male; Mice, Inbred C57BL; Nerve Fibers; Pain; Substance P; TRPA1 Cation Channel; TRPV Cation Channels; Up-Regulation | 2018 |
Substance P-regulated leukotriene B4 production promotes acute pancreatitis-associated lung injury through neutrophil reverse migration.
Topics: Acinar Cells; Acute Lung Injury; Animals; Benzoates; Cells, Cultured; Ceruletide; Disease Models, Animal; Humans; Leukotriene B4; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Neutrophils; Pancreatitis, Acute Necrotizing; Protein Kinase C; Receptors, Leukotriene B4; Receptors, Neurokinin-1; Substance P; Transendothelial and Transepithelial Migration | 2018 |
Non-pharmacological treatment affects neuropeptide expression in neuropathic pain model.
Topics: Animals; Disease Models, Animal; Ganglia, Spinal; Gene Expression Regulation; Male; Muscle Strength; Musculoskeletal Manipulations; Nerve Tissue Proteins; Neuralgia; Neurons; Neuropeptides; Rats; Rats, Wistar; Receptors, Opioid; Substance P; TRPV Cation Channels | 2018 |
Substance P Modulation of Human and Murine Corneal Neovascularization.
Topics: Adult; Aged; Aged, 80 and over; Animals; Cornea; Corneal Neovascularization; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Substance P; Tears; Young Adult | 2018 |
Allergic Rhinitis in Rats Is Associated with an Inflammatory Response of the Hippocampus.
Topics: Animals; CD11 Antigens; Disease Models, Animal; Glial Fibrillary Acidic Protein; Hippocampus; Inflammation; Interleukin-6; Male; Ovalbumin; Rats; Rats, Sprague-Dawley; Rhinitis, Allergic; Substance P; Tumor Necrosis Factor-alpha | 2018 |
Cardioprotective effect of substance P in a porcine model of acute myocardial infarction.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Infusions, Intravenous; Male; Myocardial Infarction; Myocardial Reperfusion; Random Allocation; Substance P; Swine; Treatment Outcome | 2018 |
Blocking Mammalian Target of Rapamycin (mTOR) Alleviates Neuropathic Pain Induced by Chemotherapeutic Bortezomib.
Topics: Animals; Behavior, Animal; Bortezomib; Calcitonin Gene-Related Peptide; Carrier Proteins; Chromones; Disease Models, Animal; Intracellular Signaling Peptides and Proteins; Male; Morpholines; Neuralgia; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Spinal Cord; Substance P; TOR Serine-Threonine Kinases; Up-Regulation | 2018 |
Neurokinin-1 Receptor Deficiency Improves Survival in Murine Polymicrobial Sepsis Through Multiple Mechanisms in Aged Mice.
Topics: Animals; Cecum; Chemokine CXCL2; Disease Models, Animal; Hemodynamics; Inflammation; Interleukin-6; Ligation; Mice; Mice, Knockout; Punctures; Receptors, Neurokinin-1; Sepsis; Substance P | 2019 |
Systemic Injection of Substance P Promotes Murine Calvarial Repair Through Mobilizing Endogenous Mesenchymal Stem Cells.
Topics: Administration, Intravenous; Animals; CD11b Antigen; Cell Survival; Craniofacial Dysostosis; Disease Models, Animal; Flow Cytometry; Integrin beta1; Leukocyte Common Antigens; Mesenchymal Stem Cells; Mice; Neurotransmitter Agents; Substance P; Treatment Outcome; X-Ray Microtomography | 2018 |
Sensory nerves mediate spontaneous behaviors in addition to inflammation in a murine model of psoriasis.
Topics: Animals; Calcitonin Gene-Related Peptide; Denervation; Disease Models, Animal; Diterpenes; Imiquimod; Inflammation; Male; Mice; Mice, Inbred C57BL; Psoriasis; Reactive Nitrogen Species; Reactive Oxygen Species; Sensory Receptor Cells; Skin; Substance P; TRPA1 Cation Channel; TRPV Cation Channels | 2019 |
Role of neurotransmitters 5-hydroxytryptamine and substance P in anorexia induction following oral exposure to the trichothecene T-2 toxin.
Topics: Animals; Anorexia; Disease Models, Animal; Female; Humans; Neurotransmitter Agents; Receptors, Neurokinin-1; Receptors, Serotonin, 5-HT3; Serotonin; Substance P; T-2 Toxin | 2019 |
Antagonism of Transient Receptor Potential Ankyrin Type-1 Channels as a Potential Target for the Treatment of Trigeminal Neuropathic Pain: Study in an Animal Model.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Hyperalgesia; Immunohistochemistry; Male; Pain; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Substance P; Trigeminal Nerve Diseases; TRPA1 Cation Channel; TRPV Cation Channels | 2018 |
TRPA1 and substance P mediate stress induced duodenal lesions in water immersion restraint stress rat model.
Topics: Animals; Blotting, Western; Disease Models, Animal; Duodenal Diseases; Duodenum; Ganglia, Spinal; Immunohistochemistry; Intestinal Mucosa; Male; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Stress, Physiological; Substance P; TRPA1 Cation Channel | 2018 |
Tendinosis-like changes in denervated rat Achilles tendon.
Topics: Achilles Tendon; Animals; Biopsy; Denervation; Disease Models, Animal; Female; Humans; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Sciatic Nerve; Substance P; Tendinopathy | 2018 |
The establishment of a mouse model of deep endometriosis.
Topics: Animals; Calcitonin Gene-Related Peptide; Cell Transdifferentiation; Disease Models, Animal; Endometriosis; Endometrium; Epithelial-Mesenchymal Transition; Female; Fibrosis; Humans; Injections, Intraperitoneal; Mice; Myofibroblasts; Peritoneal Diseases; Peritoneum; Substance P | 2019 |
Pulp response of rats submitted to bleaching and the use of different anti-inflammatory drugs.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Calcitonin Gene-Related Peptide; Dental Pulp; Disease Models, Animal; Drug Combinations; Humans; Hydrocortisone; Immunohistochemistry; Male; Neomycin; Polymyxin B; Pulpitis; Rats; Rats, Wistar; Substance P; Tooth Bleaching; Tooth Bleaching Agents | 2019 |
Anti-NGF treatment can reduce chronic neuropathic pain by changing peripheral mediators and brain activity in rats.
Topics: Animals; Antibodies; Brain; Disease Models, Animal; Ganglia, Spinal; Male; Nerve Growth Factor; Pain Measurement; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Sciatic Neuropathy; Spinal Cord; Substance P; Time Factors; Up-Regulation | 2019 |
Hemokinin-1 is an important mediator of pain in mouse models of neuropathic and inflammatory mechanisms.
Topics: Analgesics; Animals; Disease Models, Animal; Female; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nociception; Pain; Protein Precursors; Receptors, Neurokinin-1; Sciatic Nerve; Spinal Cord Dorsal Horn; Substance P; Tachykinins | 2019 |
ISSLS Prize in Basic science 2019: Physical activity attenuates fibrotic alterations to the multifidus muscle associated with intervertebral disc degeneration.
Topics: Animals; Collagen Type I; Collagen Type III; Connective Tissue; Connective Tissue Growth Factor; Disease Models, Animal; Fibronectins; Fibrosis; Gene Regulatory Networks; Intervertebral Disc Degeneration; Matrix Metalloproteinase 2; Mice, Knockout; Paraspinal Muscles; Physical Conditioning, Animal; Substance P; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2 | 2019 |
Involvement of Substance P in the Analgesic Effect of Low-Level Laser Therapy in a Mouse Model of Chronic Widespread Muscle Pain.
Topics: Acids; Animals; Capsaicin; Chronic Pain; Cnidarian Venoms; Disease Models, Animal; Dose-Response Relationship, Drug; Fibromyalgia; Laser Therapy; Low-Level Light Therapy; Mice; Mice, Inbred C57BL; Mice, Knockout; Musculoskeletal Pain; Protein Precursors; Signal Transduction; Substance P; Tachykinins; TRPV Cation Channels | 2019 |
Substance P accelerates wound repair by promoting neovascularization and preventing inflammation in an ischemia mouse model.
Topics: Animals; Disease Models, Animal; Inflammation; Inflammation Mediators; Ischemia; Male; Mice; Mice, Inbred BALB C; Neovascularization, Physiologic; Neurotransmitter Agents; Skin; Substance P; Wound Healing | 2019 |
Hypothalamic Reproductive Endocrine Pulse Generator Activity Independent of Neurokinin B and Dynorphin Signaling.
Topics: Academic Medical Centers; Adolescent; Adult; Animals; Case-Control Studies; Child; Disease Models, Animal; Dynorphins; Female; Gonadotropin-Releasing Hormone; Humans; Hypogonadism; Kisspeptins; Luteinizing Hormone; Mice; Mice, Knockout; Narcotic Antagonists; Neurokinin B; Neurons; Signal Transduction; Substance P; Treatment Outcome; Young Adult | 2019 |
Effect of neurokinin-1-receptor blockage on fracture healing in rats.
Topics: Animals; Collagen Type I; Collagen Type II; Disease Models, Animal; Femoral Fractures; Fracture Healing; Gene Expression Regulation, Neoplastic; Male; Neurokinin-1 Receptor Antagonists; Osteocalcin; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Substance P; Treatment Outcome | 2019 |
Infrapatellar fat pad-derived MSC response to inflammation and fibrosis induces an immunomodulatory phenotype involving CD10-mediated Substance P degradation.
Topics: Adipose Tissue; Adult; Animals; Bone Marrow Cells; Cells, Cultured; Connective Tissue Growth Factor; Cytokines; Disease Models, Animal; Female; Fibrosis; Healthy Volunteers; Humans; Inflammation; Intercellular Signaling Peptides and Proteins; Interferon-gamma; Male; Mesenchymal Stem Cells; Middle Aged; Neprilysin; Phenotype; Proteolysis; Rats; Rats, Sprague-Dawley; Substance P; Synovitis; Tumor Necrosis Factor-alpha | 2019 |
Interleukin-17/T-helper 17 cells in an atopic dermatitis mouse model aggravate orthodontic root resorption in dental pulp.
Topics: Adolescent; Adult; Animals; CD4-Positive T-Lymphocytes; Cells, Cultured; Coculture Techniques; Dental Pulp; Dermatitis, Atopic; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin E; Interleukin-17; Interleukin-6; Interleukin-8; Male; Mice; Real-Time Polymerase Chain Reaction; Receptors, Interleukin-17; Root Resorption; Substance P; Th17 Cells; Tooth Movement Techniques | 2013 |
Bladder outlet obstruction triggers neural plasticity in sensory pathways and contributes to impaired sensitivity in erectile dysfunction.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Erectile Dysfunction; Ganglia, Spinal; Male; Muscle, Smooth; Neuronal Plasticity; Neurons; Penis; Rats; Rats, Sprague-Dawley; Substance P; Urinary Bladder; Urinary Bladder Neck Obstruction | 2013 |
Genomic and non-genomic effects of glucocorticoids on allergic rhinitis model in mice.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Cinnamates; Disease Models, Animal; Estrenes; Female; Genomics; Glucocorticoids; Histamine; Hormone Antagonists; Mice; Mice, Inbred ICR; Mifepristone; Mometasone Furoate; ortho-Aminobenzoates; Phospholipase A2 Inhibitors; Pregnadienediols; Pyrrolidinones; Receptors, Glucocorticoid; Rhinitis, Allergic; Rhinitis, Allergic, Perennial; Sneezing; Substance P; Type C Phospholipases | 2013 |
Pain‑relieving effect of a compound isolated from white peony root oral liquid on acute radiation‑induced esophagitis.
Topics: Administration, Oral; Anesthetics, Local; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Body Weight; Dexamethasone; Disease Models, Animal; Esophagitis; Gentamicins; Immunohistochemistry; Lidocaine; Male; Paeonia; Pain Management; Plant Extracts; Plant Roots; Radiation Injuries; Rats; Rats, Wistar; Substance P; X-Rays | 2013 |
Excitatory superficial dorsal horn interneurons are functionally heterogeneous and required for the full behavioral expression of pain and itch.
Topics: Animals; Cell Death; Cognition Disorders; Disease Models, Animal; Glutamate Decarboxylase; Green Fluorescent Proteins; Hyperalgesia; Interneurons; Lectins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oncogene Proteins v-fos; Pain; Pain Threshold; Phosphopyruvate Hydratase; Pruritus; Reaction Time; Receptors, Steroid; Receptors, Thyroid Hormone; Spinal Nerve Roots; Substance P | 2013 |
Effects of UCMS-induced depression on nociceptive behaviors induced by electrical stimulation of the dura mater.
Topics: Animals; Calcitonin Gene-Related Peptide; Depression; Disease Models, Animal; Dura Mater; Electric Stimulation; Male; Nociception; Rats; Rats, Sprague-Dawley; Stress, Physiological; Substance P | 2013 |
Neurokinin-1 receptor-expressing neurons that contain serotonin and gamma-aminobutyric acid in the rat rostroventromedial medulla are involved in pain processing.
Topics: Animals; Biotin; Cell Count; Dextrans; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Green Fluorescent Proteins; Medulla Oblongata; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Pathways; Neurons; Pain; Rats; Receptors, Neurokinin-1; Serotonin; Stilbamidines; Substance P | 2013 |
Role of transient receptor potential ion channels and evoked levels of neuropeptides in a formaldehyde-induced model of asthma in BALB/c mice.
Topics: Acetanilides; Animals; Asthma; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Formaldehyde; Immunoglobulin E; Immunohistochemistry; Interleukin-1beta; Interleukin-4; Interleukin-6; Lung; Male; Mice; Mice, Inbred BALB C; Neuropeptides; Ovalbumin; Purines; Substance P; Transient Receptor Potential Channels | 2013 |
Increased expression of 5-HT3 and NK 1 receptors in 5-fluorouracil-induced mucositis in mouse jejunum.
Topics: Animals; Autocrine Communication; Disease Models, Animal; Fluorouracil; Jejunal Diseases; Macrophages; Male; Mast Cells; Mice; Mice, Inbred C57BL; Mucositis; Paracrine Communication; Receptors, Neurokinin-1; Receptors, Serotonin, 5-HT3; Substance P; Up-Regulation | 2013 |
[Effect of food allergy early in life on visceral hyperalgesia in the developing rats and role of substance P abnormal expression in colon].
Topics: Animals; Colonic Diseases, Functional; Disease Models, Animal; Electrophysiology; Female; Food Hypersensitivity; Hyperalgesia; Intestinal Mucosa; Mast Cells; Ovalbumin; Pain Threshold; Rats; Rats, Sprague-Dawley; Stress, Psychological; Substance P | 2013 |
TRPA1 ion channels in vagal afferent nerves contribute to ventilator-induced lung injury in a rat model.
Topics: Afferent Pathways; Animals; Disease Models, Animal; Gene Expression Regulation; Male; Malondialdehyde; Rats; Rats, Sprague-Dawley; Substance P; Superoxide Dismutase; TRPA1 Cation Channel; TRPC Cation Channels; Vagus Nerve; Ventilator-Induced Lung Injury | 2013 |
Mechanism underlying anti-hyperalgesic and anti-allodynic properties of anomalin in both acute and chronic inflammatory pain models in mice through inhibition of NF-κB, MAPKs and CREB signaling cascades.
Topics: Acute Disease; Adenosine Triphosphate; Analgesics; Animals; Chronic Disease; Coumarins; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Hyperalgesia; Inflammation; Liver; Male; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase Type II; Nitrites; Pain; Signal Transduction; Substance P; Time Factors; Tumor Necrosis Factor-alpha | 2013 |
Substance P as a mediator of neurogenic inflammation after balloon compression induced spinal cord injury.
Topics: Animals; Aquaporin 4; Capillary Permeability; Cerebrospinal Fluid Pressure; Disease Models, Animal; Edema; Neurogenic Inflammation; Rabbits; Recovery of Function; Spinal Cord Injuries; Substance P | 2013 |
Substance P acting via the neurokinin-1 receptor regulates adverse myocardial remodeling in a rat model of hypertension.
Topics: Animals; Disease Models, Animal; Female; Gene Expression Regulation, Developmental; Heart Ventricles; Hypertension; Myocytes, Cardiac; Polymerase Chain Reaction; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Neurokinin-1; RNA, Messenger; Substance P; Ventricular Function, Left; Ventricular Remodeling | 2013 |
Wound contraction decreases with intravenously injected substance P in rabbits.
Topics: Animals; Disease Models, Animal; Ear; Injections, Intravenous; Integrin beta1; Rabbits; Skin; Stromal Cells; Substance P; Wound Healing; Wounds and Injuries | 2014 |
Effects of intrathecal SNC80, a delta receptor ligand, on nociceptive threshold and dorsal horn substance p release.
Topics: Animals; Benzamides; Disease Models, Animal; Injections, Spinal; Ligands; Male; Pain; Pain Threshold; Piperazines; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Opioid, delta; Substance P | 2013 |
Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model.
Topics: Animals; Berberine; Caspase 3; Cerebral Cortex; Depression; Disease Models, Animal; Dopamine; Hippocampus; Hyperalgesia; Interleukin-1beta; Male; NF-kappa B; Nitrites; Nociception; Norepinephrine; Oxidative Stress; Pain; Rats, Wistar; Reserpine; Serotonin; Signal Transduction; Substance P; Superoxide Dismutase | 2013 |
Substance P receptor antagonist in lateral habenula improves rat depression-like behavior.
Topics: Animals; Chromatography, High Pressure Liquid; Depression; Disease Models, Animal; Habenula; Injections, Intraventricular; Male; Microdialysis; Microinjections; Neurokinin-1 Receptor Antagonists; Raphe Nuclei; Rats; Rats, Wistar; Serotonin; Substance P | 2014 |
An amino-terminal fragment of hemokinin-1 has an inhibitory effect on pruritic processing in rats.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Drug Administration Routes; Injections, Spinal; Male; Pain Measurement; Peptide Fragments; Proto-Oncogene Proteins c-fos; Pruritus; Rats; Rats, Sprague-Dawley; Substance P; Tachykinins; Time Factors | 2014 |
Systemic administration of substance P recovers beta amyloid-induced cognitive deficits in rat: involvement of Kv potassium channels.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Cognition; Cognition Disorders; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Kv1.4 Potassium Channel; Male; Maze Learning; Peptide Fragments; Potassium Channels, Voltage-Gated; Rats; Rats, Sprague-Dawley; Substance P | 2013 |
A rat model of full thickness thermal injury characterized by thermal hyperalgesia, mechanical allodynia, pronociceptive peptide release and tramadol analgesia.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Burns; Calcitonin Gene-Related Peptide; Disease Models, Animal; Hyperalgesia; Male; Morphine; Nociception; Nociceptive Pain; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Tramadol | 2014 |
Effort-related motivational effects of the VMAT-2 inhibitor tetrabenazine: implications for animal models of the motivational symptoms of depression.
Topics: Adenosine A2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Bupropion; Conditioning, Operant; Depression; Disease Models, Animal; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Enkephalins; Feeding Behavior; Immunohistochemistry; Male; Microdialysis; Motivation; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Substance P; Tetrabenazine; Vesicular Monoamine Transport Proteins; Xanthines | 2013 |
Shugan-decoction relieves visceral hyperalgesia and reduces TRPV1 and SP colon expression.
Topics: Analgesics; Animals; Behavior, Animal; Colon; Disease Models, Animal; Down-Regulation; Drugs, Chinese Herbal; Hyperalgesia; Male; Pain Threshold; Rats; Rats, Wistar; Reflex; RNA, Messenger; Stress, Psychological; Substance P; TRPV Cation Channels; Visceral Afferents | 2013 |
Changes of T-helper type 1/2 cell balance by anticholinergic treatment in allergic mice.
Topics: Adrenergic Agents; Animals; Cholinergic Antagonists; Cholinergic Neurons; Disease Models, Animal; Eosinophils; Female; Forkhead Transcription Factors; Gene Expression; Immunoglobulin E; Interferon-gamma; Interleukin-4; Ipratropium; Mice; Mice, Inbred BALB C; Nasal Mucosa; Ovalbumin; Oxidopamine; Parasympathetic Nervous System; Rhinitis, Allergic; Rhinitis, Allergic, Perennial; Substance P; Th1 Cells; Th1-Th2 Balance; Th2 Cells; Vasoactive Intestinal Peptide | 2014 |
[Changes of CCK-8, CGRP, SP, and VIP in the colon and the lung tissue of allergic asthma model rats: an experimental observation].
Topics: Animals; Asthma; Calcitonin Gene-Related Peptide; Colon; Disease Models, Animal; Lung; Male; Rats; Rats, Wistar; Sincalide; Substance P; Vasoactive Intestinal Peptide | 2013 |
μ-Opioid receptor inhibition of substance P release from primary afferents disappears in neuropathic pain but not inflammatory pain.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ganglia, Spinal; Hyperalgesia; Inflammation; Male; Neurons; Pain; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Opioid, mu; Sciatic Nerve; Sciatica; Spinal Cord; Substance P | 2014 |
Increased neuronal expression of neurokinin-1 receptor and stimulus-evoked internalization of the receptor in the rostral ventromedial medulla of the rat after peripheral inflammatory injury.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Freund's Adjuvant; Glial Fibrillary Acidic Protein; Hyperalgesia; Inflammation; Male; Medulla Oblongata; Neurons; Peripheral Nerve Injuries; Phosphopyruvate Hydratase; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P | 2014 |
In vitro smooth muscle contractility before and after relief of experimental obstruction in the rat: application to the surgical management of ileal dilatation.
Topics: Acetylcholine; Animals; Dilatation, Pathologic; Disease Models, Animal; Electric Stimulation; Gastrointestinal Motility; Histamine; Ileal Diseases; In Vitro Techniques; Intestinal Obstruction; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Postoperative Period; Potassium Chloride; Random Allocation; Rats; Rats, Wistar; Substance P | 2014 |
Anchoring a cytoactive factor in a wound bed promotes healing.
Topics: Animals; Biomimetic Materials; Collagen; Disease Models, Animal; Immobilized Proteins; Male; Mice; Mice, Mutant Strains; Peptides; Substance P; Wound Healing; Wounds and Injuries | 2016 |
Effect of rikkunshito on the expression of substance P and CGRP in dorsal root ganglion neurons and voluntary movement in rats with experimental reflux esophagitis.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Drugs, Chinese Herbal; Esophagitis, Peptic; Ganglia, Spinal; Male; Movement; Neurons; Omeprazole; Proton Pump Inhibitors; Rats; Rats, Wistar; Substance P | 2014 |
Antiemetic role of thalidomide in a rat model of cisplatin-induced emesis.
Topics: Animals; Antiemetics; Antineoplastic Agents; Cisplatin; Disease Models, Animal; Eating; Kaolin; Male; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P; Thalidomide; Vomiting | 2014 |
Inhibitors of endopeptidase and angiotensin-converting enzyme lead to an amplification of the morphological changes and an upregulation of the substance P system in a muscle overuse model.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Cumulative Trauma Disorders; Disease Models, Animal; Female; Immunohistochemistry; Injections; Muscle, Skeletal; Myositis; Necrosis; Protease Inhibitors; Rabbits; Receptors, Neurokinin-1; Signal Transduction; Substance P; Time Factors; Up-Regulation | 2014 |
Abnormal response to the anorexic effect of GHS-R inhibitors and exenatide in male Snord116 deletion mouse model for Prader-Willi syndrome.
Topics: Analysis of Variance; Animals; Anorexia; Disease Models, Animal; Eating; Exenatide; Fasting; Ghrelin; Humans; Hyperphagia; Hypoglycemic Agents; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligopeptides; Peptides; Piperidines; Prader-Willi Syndrome; Quinazolinones; Receptors, Ghrelin; RNA, Small Nucleolar; Substance P; Venoms | 2014 |
Effects of Qufeng Xuanfei decoction in animal model of post-infectious cough.
Topics: Animals; Bronchoalveolar Lavage; Calcitonin Gene-Related Peptide; Cell Count; Cough; Disease Models, Animal; Drugs, Chinese Herbal; Infections; Lung; Male; Neurokinin A; Neurokinin B; Rats; Rats, Sprague-Dawley; Substance P | 2014 |
[Effect of electroacupuncture stimulation of "Ganshu" (BL 18) on locomotor, gastric mucosal and hypothalamic SP immunoactivity and hippocampal 5-HT content in rats with depression and gastric ulcer].
Topics: Acupuncture Points; Animals; Depression; Disease Models, Animal; Electroacupuncture; Gastric Mucosa; Hippocampus; Humans; Male; Rats; Rats, Sprague-Dawley; Serotonin; Stomach Ulcer; Substance P | 2014 |
Treatment with the NK1 antagonist emend reduces blood brain barrier dysfunction and edema formation in an experimental model of brain tumors.
Topics: Animals; Aprepitant; Blood-Brain Barrier; Brain Edema; Brain Neoplasms; Disease Models, Animal; Humans; Male; Mice; Morpholines; Neurokinin-1 Receptor Antagonists; Permeability; Receptors, Neurokinin-1; Substance P | 2014 |
Forced treadmill running suppresses postincisional pain and inhibits upregulation of substance P and cytokines in rat dorsal root ganglion.
Topics: Analysis of Variance; Animals; Cytokines; Disease Models, Animal; Exercise Test; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Interleukin-1beta; Interleukin-6; Male; Pain Measurement; Pain Threshold; Pain, Postoperative; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley; Substance P; Time Factors | 2014 |
NK1 receptor blockade is ineffective in improving outcome following a balloon compression model of spinal cord injury.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Inflammation; Neurokinin-1 Receptor Antagonists; Protease Inhibitors; Rabbits; Receptors, Neurokinin-1; Spinal Cord Compression; Substance P; Tryptophan | 2014 |
Bortezomib treatment produces nocifensive behavior and changes in the expression of TRPV1, CGRP, and substance P in the rat DRG, spinal cord, and sciatic nerve.
Topics: Animals; Behavior, Animal; Boronic Acids; Bortezomib; Calcitonin Gene-Related Peptide; Disease Models, Animal; Female; Ganglia, Spinal; Gene Expression Regulation; Nerve Tissue Proteins; Nociception; Peripheral Nervous System Diseases; Pyrazines; Rats; Rats, Wistar; Sciatic Nerve; Spinal Cord; Substance P; TRPV Cation Channels | 2014 |
Acid mediates a prolonged antinociception via substance P signaling in acid-induced chronic widespread pain.
Topics: Acid Sensing Ion Channels; Acids; Animals; Capsaicin; Chronic Pain; Cnidarian Venoms; Disease Models, Animal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Pain Measurement; Signal Transduction; Substance P; TRPV Cation Channels | 2014 |
The selective PAC1 receptor agonist maxadilan inhibits neurogenic vasodilation and edema formation in the mouse skin.
Topics: Animals; Capillary Permeability; Disease Models, Animal; Ear; Edema; Female; Insect Proteins; Male; Mice; Microcirculation; Mustard Plant; Peroxidase; Plant Oils; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; Receptors, Vasoactive Intestinal Peptide, Type II; Receptors, Vasoactive Intestinal Polypeptide, Type I; Skin Physiological Phenomena; Substance P; Vasoactive Intestinal Peptide; Vasoconstrictor Agents; Vasodilation | 2014 |
Substance P is associated with hypothalamic paraventricular nucleus activation that coincides with increased urotensin 2 mRNA in chicks.
Topics: Animals; Anorexia; Appetite Depressants; Chickens; Diencephalon; Disease Models, Animal; Drinking; Eating; Female; Infusions, Intraventricular; Male; Paraventricular Hypothalamic Nucleus; RNA, Messenger; Substance P; Urotensins | 2014 |
Hemokinin-1 mediates pruriceptive processing in the rat spinal cord.
Topics: Animals; Disease Models, Animal; Formaldehyde; Histamine; Immunohistochemistry; Male; Nociception; Pain; Proto-Oncogene Proteins c-fos; Pruritus; Rats, Sprague-Dawley; Serotonin; Spinal Cord; Substance P; Tachykinins | 2014 |
Effects of substance P during the recovery of hearing function after noise-induced hearing loss.
Topics: Animals; Auditory Threshold; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Guinea Pigs; Hair Cells, Auditory, Outer; Hearing Loss, Noise-Induced; Neuroprotective Agents; Recovery of Function; Severity of Illness Index; Substance P; Synapses | 2014 |
Neurokinin-1 receptor antagonist orvepitant is an effective inhibitor of itch-associated response in a Mongolian gerbil model of scratching behaviour.
Topics: Administration, Oral; Animals; Antipruritics; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Dose-Response Relationship, Drug; Gerbillinae; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pruritus; Substance P | 2014 |
Eosinophil-dependent skin innervation and itching following contact toxicant exposure in mice.
Topics: Allergens; Animals; Cell Degranulation; Collagen; Dinitrofluorobenzene; Disease Models, Animal; Eosinophilia; Eosinophils; Fibrosis; Inflammation; Mice; Phthalic Anhydrides; Pruritus; Skin; Substance P | 2015 |
Roles of Toll-Like Receptor 4, IκB Kinase, and the Proteasome in the Intestinal Alterations Caused by Sepsis.
Topics: Acetylcholine; Animals; Cell-Penetrating Peptides; Cytokines; Dinoprostone; Disease Models, Animal; Duodenum; Endotoxins; Gastrointestinal Motility; Gene Expression Regulation; I-kappa B Kinase; Inflammation Mediators; Leupeptins; Male; Muscle Contraction; Neomycin; Polymyxin B; Potassium Chloride; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinase Inhibitors; Rabbits; Sepsis; Signal Transduction; Substance P; Toll-Like Receptor 4 | 2015 |
Plasma pharmacokinetics and tissue and brain distribution of cisplatin in musk shrews.
Topics: Animals; Antineoplastic Agents; Blood-Brain Barrier; Brain; Chemical and Drug Induced Liver Injury; Cisplatin; Disease Models, Animal; Dose-Response Relationship, Drug; Emetics; Female; Half-Life; Injections, Intraperitoneal; Kidney; Lung; Nausea; Neurons; Platinum; Shrews; Spinal Cord; Substance P; Tissue Distribution | 2015 |
Self-assembling peptide nanofibers coupled with neuropeptide substance P for bone tissue engineering.
Topics: Animals; Bone and Bones; Bone Marrow Cells; Bone Regeneration; Cell Movement; Cell Tracking; Collagen Type I; Disease Models, Animal; Fluorescent Antibody Technique; Humans; Male; Mesenchymal Stem Cells; Mice, Inbred BALB C; Nanofibers; Osteocalcin; Rats, Sprague-Dawley; Skull; Stromal Cells; Substance P; Tissue Engineering | 2015 |
Perindopril increases the swallowing reflex by inhibiting substance P degradation and tyrosine hydroxylase activation in a rat model of dysphagia.
Topics: Amantadine; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Deglutition; Deglutition Disorders; Disease Models, Animal; Enzyme Activation; Gene Expression Regulation, Enzymologic; Male; Perindopril; Proteolysis; Rats; Rats, Inbred SHR; Reflex; Substance P; Tyrosine 3-Monooxygenase; Vasodilator Agents | 2015 |
Neurochemical properties of BDNF-containing neurons projecting to rostral ventromedial medulla in the ventrolateral periaqueductal gray.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Calcitonin Gene-Related Peptide; Disease Models, Animal; Formaldehyde; Male; Medulla Oblongata; Microglia; Neural Pathways; Neurons; Neurotensin; Nitric Oxide Synthase; Pain; Parvalbumins; Periaqueductal Gray; Rats, Sprague-Dawley; Receptor, trkB; RNA, Messenger; Serotonin; Substance P; Tyrosine Decarboxylase | 2014 |
Oxidative stress and substance P mediate psychological stress-induced autophagy and delay of hair growth in mice.
Topics: Animals; Antioxidants; Autophagy; Blotting, Western; Cyclic N-Oxides; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Glutathione Peroxidase; Hair; Isoindoles; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Neurokinin-1 Receptor Antagonists; Oxidative Stress; Spin Labels; Stress, Psychological; Substance P; Superoxide Dismutase | 2015 |
L-type calcium channel blockers and substance P induce angiogenesis of cortical vessels associated with beta-amyloid plaques in an Alzheimer mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Calcium Channel Blockers; Calcium Channels, L-Type; Cerebral Cortex; Disease Models, Animal; Mice, Transgenic; Neovascularization, Pathologic; Plaque, Amyloid; RNA, Messenger; Substance P | 2015 |
Phenotypic changes in dorsal root ganglion and spinal cord in the collagen antibody-induced arthritis mouse model.
Topics: Activating Transcription Factor 3; Animals; Antibodies; Arthritis; Calcium Channels; Collagen; Disease Models, Animal; Galanin; Ganglia, Spinal; Hyperalgesia; Lectins; Lipopolysaccharides; Male; Mice; Mice, Inbred CBA; Nerve Tissue Proteins; Neuropeptide Y; Spinal Cord; Substance P; Time Factors | 2015 |
The NK1 receptor antagonist aprepitant attenuates NK1 agonist-induced scratching behaviour in the gerbil after intra-dermal, topical or oral administration.
Topics: Administration, Oral; Administration, Topical; Animals; Antipruritics; Aprepitant; Disease Models, Animal; Drug Evaluation, Preclinical; Gerbillinae; Humans; Injections, Intradermal; Morpholines; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Pruritus; Receptors, Neurokinin-1; Substance P | 2015 |
Correlation of c-fos protein expression with neuropeptide content in the lung of bronchial asthmatic rat.
Topics: Animals; Asthma; Biomarkers; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Immunohistochemistry; Male; Neuropeptides; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Substance P; Vasoactive Intestinal Peptide | 2014 |
Activation of neuroimmune pathways increases therapeutic effects of radiotherapy on poorly differentiated breast carcinoma.
Topics: Animals; Brain Neoplasms; Breast Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Disease Models, Animal; Docetaxel; Female; Mice; Mice, Inbred BALB C; Substance P; Taxoids; Treatment Outcome | 2015 |
Interrogating the aged striatum: robust survival of grafted dopamine neurons in aging rats produces inferior behavioral recovery and evidence of impaired integration.
Topics: Aging; Amphetamine; Animals; Corpus Striatum; Disease Models, Animal; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopaminergic Neurons; Dyskinesia, Drug-Induced; Embryo, Mammalian; Functional Laterality; Levodopa; Neurites; Oxidopamine; Parkinson Disease; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred F344; Recovery of Function; Stem Cell Transplantation; Substance P | 2015 |
[Experimental research on substance P content of hypothalamus and dorsal root ganglia in rats with lumbar vertebrae Gucuofeng model].
Topics: Animals; Disease Models, Animal; Ganglia, Spinal; Hypothalamus; Joint Dislocations; Lumbar Vertebrae; Male; Rats; Rats, Sprague-Dawley; Substance P | 2015 |
Blocking PAR2 attenuates oxaliplatin-induced neuropathic pain via TRPV1 and releases of substance P and CGRP in superficial dorsal horn of spinal cord.
Topics: Animals; Calcitonin Gene-Related Peptide; Cryopyrin-Associated Periodic Syndromes; Disease Models, Animal; Male; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Rats; Rats, Wistar; Receptor, PAR-2; Signal Transduction; Spinal Cord Dorsal Horn; Substance P; Treatment Outcome; TRPV Cation Channels; Up-Regulation | 2015 |
Differential Changes in the Peptidergic and the Non-Peptidergic Skin Innervation in Rat Models for Inflammation, Dry Skin Itch, and Dermatitis.
Topics: Acetone; Animals; Biopsy; Calcitonin Gene-Related Peptide; Dermatitis; Dinitrochlorobenzene; Disease Models, Animal; Freund's Adjuvant; Inflammation; Male; Nerve Fibers; Pruritus; Rats; Rats, Wistar; Receptors, Purinergic P2X3; Skin; Substance P | 2015 |
The effect of spinal cord injury on the neurochemical properties of vagal sensory neurons.
Topics: Animals; Biomarkers; Disease Models, Animal; Glycoproteins; Immunohistochemistry; Lectins; Male; Neuronal Plasticity; Neurons, Afferent; Nodose Ganglion; Rats, Wistar; Receptors, Purinergic P2X3; Spinal Cord Injuries; Substance P; Urinary Bladder; Versicans | 2015 |
Small constrained SP1-7 analogs bind to a unique site and promote anti-allodynic effects following systemic injection in mice.
Topics: Analgesics; Animals; Area Under Curve; Binding Sites; Disease Models, Animal; Hyperalgesia; Male; Mice; Neuralgia; Pain Measurement; Pain Threshold; Peptide Fragments; Protein Binding; Statistics, Nonparametric; Substance P; Time Factors | 2015 |
Gelatin nanoparticle-mediated intranasal delivery of substance P protects against 6-hydroxydopamine-induced apoptosis: an in vitro and in vivo study.
Topics: Administration, Intranasal; Animals; Apoptosis; Caspase 3; Cells, Cultured; Disease Models, Animal; Drug Delivery Systems; Gelatin; Male; Molecular Structure; Nanoparticles; Oxidopamine; PC12 Cells; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Substance P; Substantia Nigra | 2015 |
Tong Xie Yao Fang relieves irritable bowel syndrome in rats via mechanisms involving regulation of 5-hydroxytryptamine and substance P.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Colon; Defecation; Disease Models, Animal; Drugs, Chinese Herbal; Enteric Nervous System; Gastrointestinal Agents; Gastrointestinal Motility; Hypothalamus; Irritable Bowel Syndrome; Rats, Wistar; Serotonin; Signal Transduction; Substance P; Time Factors | 2015 |
The effects of substance p on tendinopathy are dose-dependent: an in vitro and in vivo model study.
Topics: Animals; Cell Differentiation; Cell Proliferation; Collagen Type II; Disease Models, Animal; In Vitro Techniques; Male; Patellar Ligament; PPAR gamma; Rats; Rats, Sprague-Dawley; Stem Cells; Substance P; Tendinopathy; Tendons | 2015 |
Facilitated spinal neuropeptide signaling and upregulated inflammatory mediator expression contribute to postfracture nociceptive sensitization.
Topics: Animals; Body Temperature; Calcitonin Gene-Related Peptide; Disease Models, Animal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Neurokinin-1 Receptor Antagonists; Neuropeptides; Pain; Pain Measurement; Peptide Fragments; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord; Substance P; Tibial Fractures; Up-Regulation | 2015 |
The effects of tempol on cyclophosphamide-induced oxidative stress in rat micturition reflexes.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Calcitonin Gene-Related Peptide; Cyclic N-Oxides; Cyclophosphamide; Cystitis; Disease Models, Animal; Female; Oxidative Stress; Rats; Reactive Nitrogen Species; Reflex; Spin Labels; Substance P; Tyrosine; Urination | 2015 |
A research design for the quantification of the neuropeptides substance p and calcitonin gene-related Peptide in rat skin using Western blot analysis.
Topics: Animals; Blotting, Western; Calcitonin Gene-Related Peptide; Disease Models, Animal; Male; Nociceptive Pain; Rats; Rats, Wistar; Research Design; Substance P | 2015 |
TRPV1 sensitization mediates postinflammatory visceral pain following acute colitis.
Topics: Abdominal Pain; Acute Disease; Animals; Behavior, Animal; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Ganglia, Spinal; HEK293 Cells; Humans; Hyperalgesia; Mice, Inbred C57BL; Mice, Knockout; Neurons, Afferent; Pain Measurement; Pain Threshold; Signal Transduction; Substance P; Time Factors; Transfection; TRPV Cation Channels; Visceral Pain | 2015 |
Effects of skin-derived precursors on wound healing of denervated skin in a nude mouse model.
Topics: Animals; Calcitonin Gene-Related Peptide; Cell Proliferation; Denervation; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Mice; Mice, Nude; Nerve Regeneration; Neural Stem Cells; Skin; Stem Cell Transplantation; Substance P; Wound Healing | 2015 |
Up-Regulation of the Biosynthesis and Release of Substance P through Wnt/β-Catenin Signaling Pathway in Rat Dorsal Root Ganglion Cells.
Topics: Animals; beta Catenin; Cell Nucleus; Cells, Cultured; Cyclooxygenase 2; Disease Models, Animal; Ganglia, Spinal; Intracellular Space; Male; Peripheral Nerve Injuries; Protein Transport; Rats; Substance P; Transcription, Genetic; Wnt Signaling Pathway | 2015 |
Dual allosteric modulation of opioid antinociceptive potency by α2A-adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Agonists; Allosteric Regulation; Analgesics, Opioid; Animals; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Hot Temperature; Injections, Spinal; Male; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Nociceptive Pain; Receptors, Adrenergic, alpha-2; Spinal Cord; Substance P | 2015 |
Substance P spinal signaling induces glial activation and nociceptive sensitization after fracture.
Topics: 2-Aminoadipic Acid; Animals; Anti-Inflammatory Agents; Complex Regional Pain Syndromes; Disease Models, Animal; Edema; Excitatory Amino Acid Antagonists; Hyperalgesia; Male; Minocycline; Neuroglia; Nociception; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord; Substance P; Tibial Fractures; Time Factors | 2015 |
Therapeutic effects of neuropeptide substance P coupled with self-assembled peptide nanofibers on the progression of osteoarthritis in a rat model.
Topics: Amino Acid Sequence; Animals; Disease Models, Animal; Disease Progression; In Situ Nick-End Labeling; Molecular Sequence Data; Nanofibers; Osteoarthritis; Rats; Real-Time Polymerase Chain Reaction; Substance P; X-Ray Microtomography | 2016 |
Annular puncture with tumor necrosis factor-alpha injection enhances painful behavior with disc degeneration in vivo.
Topics: Animals; Annulus Fibrosus; Behavior, Animal; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Injections; Intervertebral Disc; Intervertebral Disc Degeneration; Lumbar Vertebrae; Male; Nerve Growth Factor; Pain; Punctures; Random Allocation; Rats; Rats, Sprague-Dawley; Substance P; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2016 |
Substance P enhances EPC mobilization for accelerated wound healing.
Topics: Animals; Cell Movement; Chemokine CXCL12; Collagen; Disease Models, Animal; Drug Combinations; Endothelial Progenitor Cells; Extracellular Matrix; Immunohistochemistry; Laminin; Male; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Neurotransmitter Agents; Proteoglycans; Substance P; Vascular Endothelial Growth Factor A; Wound Healing; Wounds and Injuries | 2016 |
Changes in the disposition of substance P in the rostral ventromedial medulla after inflammatory injury in the rat.
Topics: Actin Cytoskeleton; Animals; Disease Models, Animal; Freund's Adjuvant; Functional Laterality; Gene Expression Regulation; Hyperalgesia; Inflammation; Male; Medulla Oblongata; Mitogen-Activated Protein Kinase 6; Pain; Pain Measurement; Pain Threshold; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance P; Tachykinins | 2016 |
Acute versus chronic phase mechanisms in a rat model of CRPS.
Topics: Animals; Antibodies; Antirheumatic Agents; Body Temperature; Complex Regional Pain Syndromes; Cytokines; Disease Models, Animal; Hindlimb; Indoles; Interleukin 1 Receptor Antagonist Protein; Male; Nerve Growth Factor; Neurokinin-1 Receptor Antagonists; Nociception; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Sciatic Nerve; Substance P; Tibial Fractures; Time Factors | 2016 |
Substance P promotes diabetic wound healing by modulating inflammation and restoring cellular activity of mesenchymal stem cells.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Inflammation; Interleukin-10; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred ICR; Neovascularization, Physiologic; Neurotransmitter Agents; Substance P; Tumor Necrosis Factor-alpha; Wound Healing; Wounds and Injuries | 2016 |
Combined Treatment with Systemic and Local Delivery of Substance P Coupled with Self-Assembled Peptides for a Hind Limb Ischemia Model.
Topics: Amino Acid Sequence; Animals; Apoptosis; Biocompatible Materials; Biomarkers; Cell Movement; Disease Models, Animal; Drug Delivery Systems; Endothelial Cells; Fibrosis; Fluorescent Antibody Technique; Hindlimb; Ischemia; Mesenchymal Stem Cells; Mice, Inbred BALB C; Myocytes, Smooth Muscle; Neovascularization, Physiologic; Peptides; Rabbits; Substance P | 2016 |
Using Gelatin Nanoparticle Mediated Intranasal Delivery of Neuropeptide Substance P to Enhance Neuro-Recovery in Hemiparkinsonian Rats.
Topics: Animals; Behavior, Animal; Biomarkers; Caspase 3; Cell Line; Disease Models, Animal; Dopaminergic Neurons; Gelatin; Male; Nanoparticles; Neurotransmitter Agents; Oxidopamine; Parkinson Disease; Proto-Oncogene Proteins c-jun; Rats; Substance P; Tyrosine 3-Monooxygenase | 2016 |
Alteration of colonic excitatory tachykininergic motility and enteric inflammation following dopaminergic nigrostriatal neurodegeneration.
Topics: Animals; Benzoxazoles; Disease Models, Animal; Dopamine; Enteric Nervous System; Eosinophils; Gastrointestinal Diseases; Gastrointestinal Motility; Glial Fibrillary Acidic Protein; Indoles; Male; Mast Cells; Neurodegenerative Diseases; Oxidopamine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Sympatholytics; Tyrosine 3-Monooxygenase | 2016 |
Total Glucosides of Paeony Promote Intestinal Motility in Slow Transit Constipation Rats through Amelioration of Interstitial Cells of Cajal.
Topics: Animals; Constipation; Disease Models, Animal; Female; Gastrointestinal Motility; Glucosides; Interstitial Cells of Cajal; Neurotransmitter Agents; Nitric Oxide; Nitric Oxide Synthase; Paeonia; Prospective Studies; Proto-Oncogene Proteins c-kit; Rats; Rats, Wistar; Stem Cell Factor; Substance P; Vasoactive Intestinal Peptide | 2016 |
Neuron-astrocyte interactions in spinal cord dorsal horn in neuropathic pain development and docosahexaenoic acid therapy.
Topics: Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Diclofenac; Disease Models, Animal; Docosahexaenoic Acids; Glial Fibrillary Acidic Protein; Hyperalgesia; Male; Mice; Phosphopyruvate Hydratase; Rats; Rats, Wistar; Sciatica; Spinal Cord Dorsal Horn; Substance P; Time Factors; Weight-Bearing | 2016 |
Evidence for the existence of nociceptors in rat thoracolumbar fascia.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Fascia; Fasciitis; Inflammation; Male; Nociceptors; Rats; Rats, Sprague-Dawley; Substance P; TRPV Cation Channels | 2016 |
Substance P Promotes the Proliferation, but Inhibits Differentiation and Mineralization of Osteoblasts from Rats with Spinal Cord Injury via RANKL/OPG System.
Topics: Animals; Calcification, Physiologic; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Male; Mesenchymal Stem Cells; Osteoblasts; Osteogenesis; Osteoprotegerin; Random Allocation; RANK Ligand; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord Injuries; Substance P; Up-Regulation | 2016 |
The Role of Substance P in Pulmonary Clearance of Bacteria in Comparative Injury Models.
Topics: Animals; Bacteria; Brain Concussion; Disease Models, Animal; Female; Humans; Mice; Mice, Inbred ICR; Neurokinin-1 Receptor Antagonists; Pneumonia; Signal Transduction; Substance P; Tail; Wounds and Injuries | 2016 |
Effects of Treatment of Treadmill Combined with Electro-Acupuncture on Tibia Bone Mass and Substance PExpression of Rabbits with Sciatic Nerve Injury.
Topics: Acupuncture Points; Acupuncture Therapy; Animals; Axons; Bone and Bones; Bone Density; Disease Models, Animal; Male; Nerve Regeneration; Physical Conditioning, Animal; Rabbits; Sciatic Nerve; Substance P; Tibia | 2016 |
Gelatin microspheres containing calcitonin gene-related peptide or substance P repair bone defects in osteoporotic rabbits.
Topics: Animals; Bone and Bones; Bone Regeneration; Calcitonin Gene-Related Peptide; Delayed-Action Preparations; Disease Models, Animal; Female; Gelatin; Microscopy, Electron, Scanning; Microspheres; Osteoporosis; Ovariectomy; Rabbits; Staining and Labeling; Substance P; Wound Healing; X-Ray Microtomography | 2017 |
Impact of Psychological Stress on Pain Perception in an Animal Model of Endometriosis.
Topics: Animals; Anxiety; Corticosterone; Disease Models, Animal; Endometriosis; Enkephalins; Female; Oligopeptides; Pain Measurement; Pain Perception; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Opioid, mu; Spinal Cord; Stress, Psychological; Substance P | 2017 |
Exacerbating effects of PM2.5 in OVA-sensitized and challenged mice and the expression of TRPA1 and TRPV1 proteins in lungs.
Topics: Airway Resistance; Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Eosinophils; Female; Interleukin-13; Mice; Mice, Inbred BALB C; Nerve Growth Factor; Ovalbumin; Particulate Matter; Prostaglandin D2; Respiratory Mechanics; Substance P; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2017 |
Compromised Neurotrophic and Angiogenic Regenerative Capability during Tendon Healing in a Rat Model of Type-II Diabetes.
Topics: Achilles Tendon; Animals; Brain-Derived Neurotrophic Factor; Diabetes Mellitus, Type 2; Disease Models, Animal; Gene Expression; Male; Neovascularization, Physiologic; Nerve Growth Factor; Rats; Rats, Wistar; Receptor, trkA; Receptor, trkB; Receptors, Neurokinin-1; Substance P; Tendon Injuries; Wound Healing | 2017 |
Upregulated expression of substance P (SP) and NK1R in eczema and SP-induced mast cell accumulation.
Topics: Adolescent; Adult; Aged; Animals; Case-Control Studies; Cells, Cultured; Disease Models, Animal; Eczema; Female; Humans; Intercellular Adhesion Molecule-1; Interleukin-17; Male; Mast Cells; Mice; Mice, Inbred BALB C; Middle Aged; Receptors, Neurokinin-1; Signal Transduction; Substance P; Transcriptional Activation; Up-Regulation; Young Adult | 2017 |
Nanoemulsion Thermoreversible Pluronic F127-Based Hydrogel Containing Hyptis pectinata (Lamiaceae) Leaf Essential Oil Produced a Lasting Anti-hyperalgesic Effect in Chronic Noninflammatory Widespread Pain in Mice.
Topics: Analgesics; Animals; Chronic Pain; Disease Models, Animal; Hydrogel, Polyethylene Glycol Dimethacrylate; Lamiaceae; Male; Mice; Oils, Volatile; Pain Measurement; Periaqueductal Gray; Plant Extracts; Proto-Oncogene Proteins c-fos; Spinal Cord; Substance P | 2018 |
Substance P increases liver fibrosis by differential changes in senescence of cholangiocytes and hepatic stellate cells.
Topics: Aging; Animals; Apoptosis; Bile Ducts; Biomarkers; Biopsy, Needle; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Hepatic Stellate Cells; Humans; Immunohistochemistry; Liver Cirrhosis; Liver Function Tests; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Random Allocation; RNA, Messenger; Sensitivity and Specificity; Substance P | 2017 |
Peripheral neuritis and increased spinal cord neurochemicals are induced in a model of repetitive motion injury with low force and repetition exposure.
Topics: Animals; Behavior, Animal; Bone and Bones; Cumulative Trauma Disorders; Disease Models, Animal; Ectodysplasins; Enzyme-Linked Immunosorbent Assay; Feeding Behavior; Female; Median Nerve; Neuritis; Psychomotor Performance; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P; Time Factors; Tumor Necrosis Factor-alpha; Upper Extremity | 2008 |
The neuropeptide substance P is a critical mediator of burn-induced acute lung injury.
Topics: Acute Disease; Adjuvants, Immunologic; Animals; Blood Platelets; Burns; Capillary Permeability; Chemokines; Cytokines; Disease Models, Animal; Inflammation Mediators; Lung; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Monocytes; Neutrophils; Receptors, Neurokinin-1; RNA, Messenger; Signal Transduction; Substance P | 2008 |
Substance P is involved in the effect of histamine H3 receptor agonist, Sch 50971 on nasal allergic symptoms in mice.
Topics: Animals; Capsaicin; Cetirizine; Disease Models, Animal; Female; Histamine; Histamine Agonists; Histamine H1 Antagonists, Non-Sedating; Imidazoles; Mice; Mice, Inbred BALB C; Ovalbumin; Piperidines; Pyrrolidines; Receptors, Histamine H3; Rhinitis, Allergic, Perennial; Substance P; Thiourea | 2008 |
Gosha-jinki-gan reduces transmitter proteins and sensory receptors associated with C fiber activation induced by acetic acid in rat urinary bladder.
Topics: Acetic Acid; Animals; Disease Models, Animal; Drugs, Chinese Herbal; Female; Immunohistochemistry; Nerve Fibers, Unmyelinated; Neurokinin A; Neurokinin B; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Tachykinins; TRPV Cation Channels; Urinary Bladder; Urinary Bladder, Overactive; Urothelium | 2008 |
Substance P receptor antagonism for treatment of cryptosporidiosis in immunosuppressed mice.
Topics: Analysis of Variance; Animals; Aprepitant; Cattle; Cryptosporidiosis; Cryptosporidium parvum; Dexamethasone; Disease Models, Animal; Feces; Glucose; Immunosuppressive Agents; Jejunum; Mice; Mice, Inbred C57BL; Microvilli; Morpholines; Neurokinin-1 Receptor Antagonists; Parasite Egg Count; Random Allocation; Substance P; Weight Loss | 2008 |
Role of substance P and bradykinin in acute pancreatitis induced by secretory phospholipase A2.
Topics: Acute Disease; Amylases; Animals; Bradykinin; Bradykinin B2 Receptor Antagonists; Disease Models, Animal; Lung; Male; Neurokinin-1 Receptor Antagonists; Pancreas; Pancreatitis; Peroxidase; Phospholipases A2, Secretory; Piperidines; Pneumonia; Quinuclidines; Rats; Rats, Wistar; Receptor, Bradykinin B2; Receptors, Neurokinin-1; Substance P; Tumor Necrosis Factor-alpha | 2008 |
The VGF-derived peptide TLQP-21: a new modulatory peptide for inflammatory pain.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Embryo, Mammalian; Ganglia, Spinal; Inflammation; Male; Mice; Nerve Growth Factors; Neurons; Neuropeptides; Pain; Pain Measurement; Pain Threshold; Peptide Fragments; Substance P | 2008 |
Neuroprotective effects of dihydroprogesterone and progesterone in an experimental model of nerve crush injury.
Topics: 20-alpha-Dihydroprogesterone; Animals; Cell Adhesion Molecules, Neuronal; Disease Models, Animal; Extracellular Matrix Proteins; Gene Expression Regulation; Locomotion; Male; Molecular Weight; Myelin Proteins; Nerve Tissue Proteins; Neuroprotective Agents; Pain Threshold; Progesterone; Rats; Rats, Sprague-Dawley; Reelin Protein; Sciatic Neuropathy; Serine Endopeptidases; Sodium-Potassium-Exchanging ATPase; Substance P; Time Factors | 2008 |
Acute myocardial ischemia up-regulates substance P in the retina of rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Male; Myocardial Ischemia; Phentolamine; Propanolamines; Protein Precursors; Rats; Rats, Sprague-Dawley; Retina; Substance P; Tachykinins; Time Factors; Up-Regulation | 2008 |
Partial infraorbital nerve ligation as a model of trigeminal nerve injury in the mouse: behavioral, neural, and glial reactions.
Topics: Activating Transcription Factor 3; Analysis of Variance; Animals; Astrocytes; Behavior, Animal; Calcitonin Gene-Related Peptide; Cell Proliferation; Disease Models, Animal; Facial Nerve Injuries; Grooming; Immunohistochemistry; Ligation; Male; Medulla Oblongata; Mice; Mice, Inbred C57BL; Microglia; Neurons; Receptors, Neurokinin-1; Satellite Cells, Perineuronal; Substance P; Trigeminal Ganglion; Trigeminal Nerve Injuries; Trigeminal Neuralgia | 2008 |
Influences of surgical decompression on the dorsal horn after chronic constriction injury: changes in peptidergic and delta-opioid receptor (+) nerve terminals.
Topics: Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Decompression, Surgical; Disease Models, Animal; Functional Laterality; Gene Expression Regulation; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, delta; Sciatic Neuropathy; Substance P; Time Factors | 2008 |
Important roles of tachykinins in the development of allergic nasal hyperresponsiveness in guinea-pigs.
Topics: Allergens; Animals; Disease Models, Animal; Guinea Pigs; Humans; Nasal Lavage Fluid; Nasal Obstruction; Nasal Provocation Tests; Neurokinin A; Nose; Pollen; Receptors, Neurokinin-2; Receptors, Tachykinin; Rhinitis, Allergic, Seasonal; Sneezing; Substance P; Tachykinins | 2009 |
Intermittent hypoxia activates peptidylglycine alpha-amidating monooxygenase in rat brain stem via reactive oxygen species-mediated proteolytic processing.
Topics: Amidine-Lyases; Animals; Antioxidants; Brain Stem; Disease Models, Animal; Enzyme Activation; Hypoxia; Kinetics; Male; Metalloporphyrins; Mixed Function Oxygenases; Multienzyme Complexes; Neuropeptide Y; Peptide Hydrolases; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Sleep Apnea Syndromes; Substance P | 2009 |
Involvement of voltage-gated sodium channel Na(v)1.8 in the regulation of the release and synthesis of substance P in adult mouse dorsal root ganglion neurons.
Topics: Animals; Capsaicin; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Ganglia, Spinal; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; NAV1.8 Voltage-Gated Sodium Channel; Neurons; Potassium Chloride; Protein Precursors; Radioimmunoassay; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sciatic Neuropathy; Sodium Channels; Substance P; Tachykinins | 2008 |
Dexmedetomidine and ST-91 analgesia in the formalin model is mediated by alpha2A-adrenoceptors: a mechanism of action distinct from morphine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analgesics; Animals; Clonidine; Dexmedetomidine; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Gene Expression Regulation; Injections, Spinal; Male; Morphine; Pain; Pain Measurement; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Neurokinin-1; Substance P | 2008 |
Sprouting of substance P-expressing primary afferent central terminals and spinal micturition reflex NK1 receptor dependence after spinal cord injury.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Electromyography; Female; Injections, Spinal; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Pressure; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Reflex; Spinal Cord Ischemia; Spinal Nerves; Substance P; Time Factors; Urinary Bladder; Urination | 2008 |
Low-frequency electro-acupuncture reduces the nociceptive response and the pain mediator enhancement induced by nerve growth factor.
Topics: Animals; Disease Models, Animal; Electroacupuncture; Enzyme-Linked Immunosorbent Assay; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Male; Mice; Nerve Growth Factor; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Reaction Time; Skin; Substance P; TRPV Cation Channels | 2009 |
Cardiac damage after lesions of the nucleus tractus solitarii.
Topics: Animals; Arrhythmias, Cardiac; Baroreflex; Blood Pressure; Death, Sudden, Cardiac; Disease Models, Animal; Echocardiography, Doppler, Pulsed; Electrocardiography; Heart; Heart Rate; Male; Microinjections; Myocardium; Necrosis; Rats; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Solitary Nucleus; Substance P; Sympathetic Nervous System; Time Factors | 2009 |
Activation of tyrosine hydroxylase prevents pneumonia in a rat chronic cerebral hypoperfusion model.
Topics: Animals; Bacteria; Carotid Stenosis; Chronic Disease; Cilostazol; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; Deglutition; Disease Models, Animal; Dopamine; Enzyme Activation; Fibrinolytic Agents; Gene Expression Regulation; Ligation; Male; Pneumonia; Rats; Rats, Wistar; Regional Blood Flow; Substance P; Substantia Nigra; Tetrazoles; Time Factors; Tyrosine 3-Monooxygenase | 2009 |
High force reaching task induces widespread inflammation, increased spinal cord neurochemicals and neuropathic pain.
Topics: Analysis of Variance; Animals; Bone and Bones; Cytokines; Disease Models, Animal; Ectodysplasins; Enzyme-Linked Immunosorbent Assay; Female; Inflammation; Macrophages; Movement; Musculoskeletal System; Neural Conduction; Neuralgia; Neurokinin A; Rats; Rats, Sprague-Dawley; Sensory Thresholds; Skin; Spinal Cord; Substance P; Time Factors; Upper Extremity | 2009 |
Salt intake augments hypotensive effects of transient receptor potential vanilloid 4: functional significance and implication.
Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Ganglia, Spinal; Hypertension; Hypotension; Kidney; Male; Mesenteric Arteries; Phorbol Esters; Rats; Rats, Wistar; Ruthenium Red; Salt Tolerance; Sodium Chloride, Dietary; Substance P; TRPV Cation Channels | 2009 |
[Influence of Qingxiang San on substance P, somatostatin in rats model with the spleen and stomach wet heat syndrome].
Topics: Animals; Disease Models, Animal; Drug Combinations; Drugs, Chinese Herbal; Female; Gastrointestinal Hormones; Male; Plants, Medicinal; Pyloric Antrum; Radioimmunoassay; Random Allocation; Rats; Rats, Sprague-Dawley; Somatostatin; Splenic Diseases; Stomach Diseases; Substance P; Yin Deficiency | 2008 |
An extract (THC-002) of Ba-Wei-Die-Huang-Wan inhibits expression of tachykinins, and P2X3 and TRPV1 receptors, and inhibits ATP-induced detrusor overactivity in spontaneously hypertensive rats.
Topics: Adenosine Triphosphate; Administration, Oral; Animals; Disease Models, Animal; Down-Regulation; Drugs, Chinese Herbal; Female; Hypertension; Immunohistochemistry; Neurokinin A; Neurokinin B; Rats; Rats, Inbred SHR; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Tachykinins; TRPV Cation Channels; Urinary Bladder; Urinary Bladder, Overactive; Urination | 2009 |
Histoplasma capsulatum encodes a dipeptidyl peptidase active against the mammalian immunoregulatory peptide, substance P.
Topics: Animals; Base Sequence; Blotting, Northern; Cloning, Molecular; Dipeptidyl Peptidase 4; Disease Models, Animal; DNA Primers; Enzyme Stability; Female; Histoplasma; Histoplasmosis; Hydrogen-Ion Concentration; Hydrolysis; Mice; Mice, Inbred C57BL; Polymerase Chain Reaction; Recombinant Proteins; Substance P; Temperature; Virulence | 2009 |
Substance P upregulates LTB4 in rat adherent macrophages from granuloma induced by KMnO4.
Topics: Animals; Arachidonate 5-Lipoxygenase; Calcimycin; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Granuloma; Ionophores; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Male; Masoprocol; Microscopy, Electron, Transmission; Potassium Permanganate; Radioimmunoassay; Rats; Rats, Wistar; Substance P; Time Factors; Up-Regulation | 2009 |
Gingerol inhibits cisplatin-induced vomiting by down regulating 5-hydroxytryptamine, dopamine and substance P expression in minks.
Topics: Animals; Antiemetics; Area Postrema; Catechols; Cisplatin; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Down-Regulation; Fatty Alcohols; Ileum; Intestinal Mucosa; Male; Mink; Serotonin; Substance P; Vomiting | 2009 |
Behavioural and histological observations of sensory impairment caused by tight ligation of the trigeminal nerve in mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Functional Laterality; Male; Mice; Mice, Inbred C57BL; Pain Measurement; Pain Threshold; Physical Stimulation; Sensation Disorders; Substance P; Time Factors; Touch; Trigeminal Neuralgia | 2009 |
Nociceptive responses and spinal plastic changes of afferent C-fibers in three neuropathic pain models induced by sciatic nerve injury in the rat.
Topics: Action Potentials; Afferent Pathways; Analysis of Variance; Animals; Disease Models, Animal; Female; Gene Expression Regulation; Hyperalgesia; Lectins; Muscle, Skeletal; Nerve Fibers, Unmyelinated; Neural Conduction; Neuronal Plasticity; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Sciatica; Spinal Cord; Substance P | 2009 |
Substance P is associated with the development of brain edema and functional deficits after traumatic brain injury.
Topics: Animals; Brain Edema; Brain Injuries; Capillary Permeability; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Magnetic Resonance Imaging; Male; Microscopy, Confocal; Microscopy, Immunoelectron; Motor Activity; Neurokinin-1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Substance P; Tryptophan | 2009 |
Post-junctional facilitation of Substance P signaling in a tibia fracture rat model of complex regional pain syndrome type I.
Topics: Animals; Calcitonin Gene-Related Peptide; Cell Proliferation; Disease Models, Animal; Edema; Foot; Ganglia, Spinal; Gene Expression Regulation; Hyperemia; Inflammation; Keratinocytes; Male; Neprilysin; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Reflex Sympathetic Dystrophy; RNA, Messenger; Sciatic Nerve; Sensory Receptor Cells; Signal Transduction; Skin Temperature; Substance P; Tibial Fractures | 2009 |
Somatostatin modulates mast cell-induced responses in murine spinal neurons and satellite cells.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcium Signaling; Cells, Cultured; Disease Models, Animal; Enteric Nervous System; Ganglia, Spinal; Histamine; Ileitis; Ileum; Inflammation Mediators; Male; Mast Cells; Mice; Mice, Inbred C57BL; Receptors, Somatostatin; RNA, Messenger; Satellite Cells, Perineuronal; Schistosoma mansoni; Serotonin; Somatostatin; Substance P; Time Factors | 2009 |
The alleviating pain effect of aqueous extract from tong-xie-yao-fang, on experimental visceral hypersensitivity and its mechanism.
Topics: Abdominal Pain; Animals; Animals, Newborn; Brain; Colon; Corticotropin-Releasing Hormone; Disease Models, Animal; Drugs, Chinese Herbal; Female; Hyperalgesia; Irritable Bowel Syndrome; Maternal Deprivation; Pain Threshold; Rats; Rats, Sprague-Dawley; Serotonin; Substance P; Viscera | 2009 |
Electro-acupuncture stimulation improves motor disorders in Parkinsonian rats.
Topics: Animals; Antiparkinson Agents; Apomorphine; Brain; Disease Models, Animal; Dopamine; Dyskinesias; Electroacupuncture; Enkephalins; Glutamate Decarboxylase; Male; Medial Forebrain Bundle; Motor Activity; Neurons; Parkinsonian Disorders; Random Allocation; Rats; Rats, Wistar; RNA, Messenger; Substance P; Tyrosine 3-Monooxygenase | 2009 |
Alteration of neuropeptides in the lung tissue correlates brain death-induced neurogenic edema.
Topics: Animals; Biomarkers; Brain Death; Bronchoalveolar Lavage Fluid; Calcitonin Gene-Related Peptide; Disease Models, Animal; Female; Lung; Neurogenic Inflammation; Neuropeptide Y; Neuropeptides; Predictive Value of Tests; Pulmonary Edema; Substance P; Swine; Vasoconstriction; Vasodilation | 2009 |
Substance P and beta-endorphin mediate electro-acupuncture induced analgesia in mouse cancer pain model.
Topics: Acupuncture Analgesia; Animals; beta-Endorphin; Cell Line, Tumor; Disease Models, Animal; Electroacupuncture; Immunohistochemistry; Male; Mice; Neurotransmitter Agents; Pain Threshold; Sarcoma 180; Sciatic Nerve; Substance P | 2009 |
[Changes of mast cells and gut hormones in rats with TNBS-induced ulcerative colitis].
Topics: Animals; Colitis, Ulcerative; Disease Models, Animal; Male; Mast Cells; Rats; Rats, Sprague-Dawley; Substance P; Trinitrobenzenesulfonic Acid; Vasoactive Intestinal Peptide | 2009 |
Expression of histamine H4 receptor in human epidermal tissues and attenuation of experimental pruritus using H4 receptor antagonist.
Topics: Animals; Disease Models, Animal; Epidermis; Histamine; Histamine Antagonists; Humans; Indoles; Keratinocytes; Male; Mice; Mice, Inbred ICR; Piperazines; Pruritus; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Substance P | 2009 |
Effect of memantine on the levels of neuropeptides and microglial cells in the brain regions of rats with neuropathic pain.
Topics: Analgesics; Animals; Brain; CD11 Antigens; Disease Models, Animal; Excitatory Amino Acid Antagonists; Hyperalgesia; Hypothalamus; Male; Memantine; Microglia; Neuralgia; Neuropeptides; Periaqueductal Gray; Peripheral Nervous System Diseases; Rats; Rats, Wistar; Sciatic Neuropathy; Somatostatin; Substance P | 2009 |
Role of substance P signaling in enhanced nociceptive sensitization and local cytokine production after incision.
Topics: Analysis of Variance; Animals; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Hyperalgesia; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Growth Factor; Neurokinin-1 Receptor Antagonists; Pain Measurement; Pain Threshold; Pain, Postoperative; Piperidines; Protein Precursors; Signal Transduction; Substance P; Tachykinins; Time Factors | 2009 |
Olopatadine hydrochloride inhibits scratching behavior induced by a proteinase-activated receptor 2 agonist in mice.
Topics: Animals; Antipruritics; Behavior, Animal; Dibenzoxepins; Disease Models, Animal; Dose-Response Relationship, Drug; Mice; Mice, Inbred C57BL; Oligopeptides; Olopatadine Hydrochloride; Protein Precursors; Pruritus; Receptor, PAR-2; RNA, Messenger; Substance P; Tachykinins; Time Factors | 2009 |
Rat colitis induced by intrathecal injection of substance P.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Inflammation; Injections, Spinal; Intramolecular Oxidoreductases; Macrophage Migration-Inhibitory Factors; Male; Neurokinin-1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P | 2009 |
Substance P and beta endorphin mediate electroacupuncture induced analgesic activity in mouse cancer pain model.
Topics: Acupuncture Analgesia; Acupuncture Points; Animals; beta-Endorphin; Cell Line, Tumor; Disease Models, Animal; Electroacupuncture; Humans; Male; Mice; Mice, Inbred BALB C; Neoplasms; Pain; Pain Management; Pain Threshold; Substance P | 2009 |
Effects of memantine on soluble Alphabeta(25-35)-induced changes in peptidergic and glial cells in Alzheimer's disease model rat brain regions.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Biomarkers; Brain; CD11 Antigens; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Male; Memantine; Nerve Degeneration; Neuroglia; Neuropeptides; Nitric Oxide Synthase Type II; Oxidative Stress; Peptide Fragments; Peptide Hydrolases; Rats; Rats, Wistar; Somatostatin; Substance P | 2009 |
Unilateral focal burn injury is followed by long-lasting bilateral allodynia and neuronal hyperexcitability in spinal cord dorsal horn.
Topics: Action Potentials; Analysis of Variance; Animals; Brain Injuries; Calcitonin Gene-Related Peptide; CD11b Antigen; Disease Models, Animal; Functional Laterality; Hyperesthesia; Male; Microglia; p38 Mitogen-Activated Protein Kinases; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Posterior Horn Cells; Rats; Spinal Cord; Substance P | 2010 |
Early protection from burn-induced acute lung injury by deletion of preprotachykinin-A gene.
Topics: Acute Lung Injury; Animals; Burns; Disease Models, Animal; Male; Mice; Mice, Knockout; Protein Precursors; Substance P; Tachykinins | 2010 |
Discriminative behavioral assessment unveils remarkable reactive astrocytosis and early molecular correlates in basal ganglia of 3-nitropropionic acid subchronic treated rats.
Topics: Animals; Astrocytes; Basal Ganglia; Basal Ganglia Diseases; Behavior, Animal; Disability Evaluation; Disease Models, Animal; Excitatory Amino Acid Transporter 1; Glial Fibrillary Acidic Protein; Gliosis; Huntington Disease; Male; Movement Disorders; Neurons; Neuropsychological Tests; Neurotoxins; Nitro Compounds; Propionates; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Substance P; Synaptic Transmission; Time Factors | 2010 |
Protease-activated receptor 2-mediated protection of myocardial ischemia-reperfusion injury: role of transient receptor potential vanilloid receptors.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Cardiotonic Agents; Coronary Circulation; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; Disease Models, Animal; Fluorescent Antibody Technique; Isoindoles; Isoquinolines; L-Lactate Dehydrogenase; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Neurokinin-1 Receptor Antagonists; Oligopeptides; Peptide Fragments; Protein Kinase C-epsilon; Protein Kinase Inhibitors; Radioimmunoassay; Receptor, PAR-2; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Recovery of Function; Substance P; Sulfonamides; TRPV Cation Channels; Ventricular Function, Left; Ventricular Pressure | 2009 |
Effect of electro-acupuncture on substance P, its receptor and corticotropin-releasing hormone in rats with irritable bowel syndrome.
Topics: Animals; Colon; Corticotropin-Releasing Hormone; Disease Models, Animal; Electroacupuncture; Hypothalamus; Irritable Bowel Syndrome; Male; Mast Cells; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P | 2009 |
Differential temporal changes in brain and gut substance P mRNA expression throughout the time-course of cisplatin-induced vomiting in the least shrew (Cryptotis parva).
Topics: Animals; Antineoplastic Agents; Brain; Cisplatin; Disease Models, Animal; Gastrointestinal Tract; Gene Expression Regulation; Humans; Mice; Phylogeny; Protein Precursors; Rats; RNA, Messenger; Sequence Analysis, Protein; Shrews; Statistics as Topic; Substance P; Tachykinins; Time Factors; Vomiting | 2010 |
Neonatal bladder inflammation produces functional changes and alters neuropeptide content in bladders of adult female rats.
Topics: Aging; Animals; Animals, Newborn; Calcitonin Gene-Related Peptide; Cystitis; Disease Models, Animal; Evans Blue; Female; Irritants; Mustard Plant; Neuropeptides; Nociceptors; Plant Oils; Rats; Sensory Receptor Cells; Substance P; Time; Urinary Bladder; Zymosan | 2010 |
Galanin mediates the pathogenesis of cerulein-induced acute pancreatitis in the mouse.
Topics: Acute Disease; Animals; Ceruletide; Disease Models, Animal; Female; Galanin; Mice; Mice, Inbred BALB C; Mice, Knockout; Pancreas; Pancreatitis; Receptors, Galanin; RNA, Messenger; Severity of Illness Index; Substance P | 2010 |
Sympathetic nervous system modulation of inflammation and remodeling in the hypertensive heart.
Topics: Analysis of Variance; Angiotensin II; Animals; Cardiomegaly; Cells, Cultured; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hypertension; Inflammation Mediators; Male; Myocytes, Cardiac; Probability; Random Allocation; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Substance P; Sympathectomy; Sympathetic Nervous System; Ventricular Remodeling | 2010 |
Ghrelin decreases microvascular leak during inflammation.
Topics: Animals; Capillary Permeability; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Ghrelin; Lipopolysaccharides; Mesentery; NF-kappa B; Obesity; Rats; Rats, Sprague-Dawley; Receptors, Ghrelin; Sesquiterpenes; Signal Transduction; Substance P; Systemic Inflammatory Response Syndrome; Venules; Wounds and Injuries | 2010 |
Gene expression of pro-inflammatory cytokines and neuropeptides in diabetic wound healing.
Topics: Alloxan; Animals; Cytokines; Diabetes Mellitus, Experimental; Disease Models, Animal; Inflammation; Interleukin-6; Interleukin-8; Neuropeptide Y; Neuropeptides; Rabbits; Substance P; Wound Healing | 2011 |
Substance P signaling contributes to granuloma formation in Taenia crassiceps infection, a murine model of cysticercosis.
Topics: Animals; Cysticercosis; Disease Models, Animal; Female; Granuloma; Interleukin-1beta; Interleukin-6; Mice; Mice, Knockout; Receptors, Neurokinin-1; Signal Transduction; Substance P; Taenia; Taeniasis; Tumor Necrosis Factor-alpha | 2010 |
Effect of gingerol on substance P and NK1 receptor expression in a vomiting model of mink.
Topics: Animals; Area Postrema; Blotting, Western; Catechols; Disease Models, Animal; Fatty Alcohols; Ileum; Immunohistochemistry; Male; Mink; Receptors, Neurokinin-1; Substance P; Vomiting | 2010 |
Substance P antagonist CP-96345 blocks lung vascular leakage and inflammation more effectively than its stereoisomer CP-96344 in a mouse model of smoke inhalation and burn injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Disease Models, Animal; Mice; Smoke; Stereoisomerism; Substance P | 2010 |
[Effect of Weichang Anwan on NO and 5-HT in blood serum, SP and MC in colon in IBS-D rats].
Topics: Animals; Colon; Disease Models, Animal; Drugs, Chinese Herbal; Female; Humans; Irritable Bowel Syndrome; Mast Cells; Nitric Oxide; Random Allocation; Rats; Rats, Wistar; Serotonin; Substance P | 2009 |
Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids.
Topics: Anemia, Sickle Cell; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Cannabinoid Receptor Agonists; Cannabinoids; Cyclohexanols; Disease Models, Animal; Female; Hemoglobin, Sickle; Humans; Hyperalgesia; Male; Mice; Mice, Knockout; Mice, Transgenic; Morphine; Neuroglia; Pain; Receptors, Opioid, mu; Recombinant Proteins; Skin; Spinal Cord; Substance P | 2010 |
Differences between orofacial inflammation and cancer pain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Carcinoma 256, Walker; Disease Models, Animal; Facial Neoplasms; Facial Pain; Galanin; Hot Temperature; Hyperalgesia; Indomethacin; Inflammation; Injections, Intraperitoneal; Male; Neuropeptides; Neurotransmitter Agents; Pain Threshold; Physical Stimulation; Rats; Rats, Wistar; Reaction Time; Substance P; Touch; Trigeminal Caudal Nucleus; Vibrissae | 2010 |
The selective COX-2 inhibitor Etoricoxib reduces acute inflammatory markers in a model of neurogenic laryngitis but loses its efficacy with prolonged treatment.
Topics: Animals; Calcitonin Gene-Related Peptide; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Etoricoxib; Interleukin-10; Interleukin-1beta; Interleukin-6; Laryngitis; Male; Pyridines; Rats; Rats, Wistar; Substance P; Sulfones; Tumor Necrosis Factor-alpha | 2010 |
A novel method to quantify histochemical changes throughout the mediolateral axis of the substantia gelatinosa after spared nerve injury: characterization with TRPV1 and substance P.
Topics: Animals; Disease Models, Animal; Histocytochemistry; Image Processing, Computer-Assisted; Male; Peripheral Nervous System Diseases; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Spinal Nerve Roots; Staining and Labeling; Substance P; Substantia Gelatinosa; Synaptic Transmission; Thiamine Monophosphate; TRPV Cation Channels | 2010 |
Modulation of the CRH system by substance P/NKA in an animal model of depression.
Topics: Adrenocorticotropic Hormone; Animals; Carrier Proteins; Cerebral Cortex; Depressive Disorder; Disease Models, Animal; Feeding Behavior; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurokinin A; Olfactory Bulb; Paraventricular Hypothalamic Nucleus; Receptors, Corticotropin-Releasing Hormone; Saccharin; Substance P | 2010 |
[Effects of eye-acupuncture therapy on serum and colonic SP and VIP contents in rats with irritable bowel syndrome].
Topics: Acupuncture Therapy; Animals; Colon; Disease Models, Animal; Eye; Humans; Irritable Bowel Syndrome; Male; Random Allocation; Rats; Substance P; Vasoactive Intestinal Peptide | 2010 |
[Effect of electroacupuncture on cortical spreading depression and plasma CGRP and substance P contents in migraine rats].
Topics: Animals; Calcitonin Gene-Related Peptide; Cortical Spreading Depression; Disease Models, Animal; Electroacupuncture; Humans; Male; Migraine Disorders; Random Allocation; Rats; Rats, Sprague-Dawley; Substance P | 2010 |
Increased intramuscular pressure in lumbar paraspinal muscles and low back pain: model development and expression of substance P in the dorsal root ganglion.
Topics: Animals; Blood Flow Velocity; Calcitonin Gene-Related Peptide; Disease Models, Animal; Female; Ganglia, Spinal; Laser-Doppler Flowmetry; Low Back Pain; Lumbar Vertebrae; Muscle, Skeletal; Pressure; Rats; Rats, Sprague-Dawley; Substance P | 2010 |
Angiotensin-converting enzyme (ACE) inhibitors exacerbate histological damage and motor deficits after experimental traumatic brain injury.
Topics: Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Brain Injuries; Captopril; Cerebral Cortex; Disease Models, Animal; Enalapril; Gene Expression Regulation; Male; Motor Activity; Movement Disorders; Rats; Rats, Sprague-Dawley; Rotarod Performance Test; Substance P | 2010 |
Activation of endothelin A receptors contributes to impaired responsiveness of renal mechanosensory nerves in congestive heart failure.
Topics: Afferent Pathways; Animals; Antihypertensive Agents; Dinoprostone; Disease Models, Animal; Endothelin A Receptor Antagonists; Heart Failure; Hydrostatic Pressure; Kidney; Kidney Pelvis; Male; Mechanoreceptors; Myocardium; Organ Size; Peptides, Cyclic; Perfusion; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Sodium; Substance P; Ventricular Dysfunction, Left | 2010 |
Octreotide negates the benefit of galantide when used in the treatment of caerulein-induced acute pancreatitis in mice.
Topics: Acute Disease; Amylases; Animals; Biomarkers; Ceruletide; Disease Models, Animal; Drug Therapy, Combination; Galanin; Lipase; Male; Mice; Octreotide; Pancreas; Pancreatitis; Peroxidase; Substance P; Time Factors | 2010 |
Role of substance P in viral myocarditis in mice.
Topics: Animals; Cardiovirus Infections; Disease Models, Animal; Encephalomyocarditis virus; Immunoenzyme Techniques; Immunohistochemistry; Male; Mice; Mice, Inbred DBA; Myocarditis; Myocardium; Substance P; Time Factors | 2010 |
The antiemetic 5-HT3 receptor antagonist Palonosetron inhibits substance P-mediated responses in vitro and in vivo.
Topics: Action Potentials; Animals; Antiemetics; Antineoplastic Agents; Calcium; Cell Line; Cisplatin; Disease Models, Animal; Dose-Response Relationship, Drug; Isoquinolines; Male; Neurokinin-1 Receptor Antagonists; Neurons; Nodose Ganglion; Palonosetron; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin 5-HT3 Receptor Antagonists; Substance P; Vomiting | 2010 |
Plasticity of hyperpolarization-activated and cyclic nucleotid-gated cation channel subunit 2 expression in the spinal dorsal horn in inflammatory pain.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Freund's Adjuvant; Functional Laterality; Gene Expression Regulation; Hyperalgesia; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Inflammation; Ion Channels; Male; Microscopy, Confocal; Pain; Pain Measurement; Posterior Horn Cells; Potassium Channels; Presynaptic Terminals; Rats; Rats, Inbred WKY; Spinal Cord; Substance P | 2010 |
Sensitized peripheral nociception in experimental diabetes of the rat.
Topics: Action Potentials; Animals; Behavior, Animal; Bradykinin; Calcitonin Gene-Related Peptide; Capsaicin; Diabetes Mellitus, Experimental; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; In Vitro Techniques; Male; Nerve Fibers; Nociceptors; Pain Measurement; Pain Threshold; Rats; Reaction Time; Sciatic Nerve; Skin; Streptozocin; Substance P | 2010 |
Spinal cord mechanisms mediating behavioral hyperalgesia induced by neurokinin-1 tachykinin receptor activation in the rostral ventromedial medulla.
Topics: Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Freund's Adjuvant; GABA Agents; Hyperalgesia; In Vitro Techniques; Inflammation; Male; Medulla Oblongata; Membrane Potentials; Microinjections; Muscimol; Ondansetron; Oxazines; Pain Measurement; Pain Threshold; Posterior Horn Cells; Pyridazines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-1; Serotonin Antagonists; Spinal Cord; Substance P; Tryptophan; Up-Regulation | 2010 |
Substance P upregulates cyclooxygenase-2 and prostaglandin E metabolite by activating ERK1/2 and NF-kappaB in a mouse model of burn-induced remote acute lung injury.
Topics: Acute Lung Injury; Animals; Blotting, Western; Burns; Chemokines; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Prostaglandins E; Signal Transduction; Substance P; Up-Regulation | 2010 |
[Study on effect of sensory neuropeptide in steroid-induced avascular necrosis of femoral head].
Topics: Animals; Antibodies, Monoclonal; Calcitonin Gene-Related Peptide; Disease Models, Animal; Female; Femur Head Necrosis; Rabbits; Steroids; Substance P | 2010 |
Bronchoconstrictor effect of the tachykinin NK₃-receptor agonists [MePhe⁷]-neurokinin B and senktide in the isolated guinea pig lung.
Topics: Animals; Bronchoconstriction; Bronchoconstrictor Agents; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; Guinea Pigs; In Vitro Techniques; Lung; Male; Peptide Fragments; Piperidines; Quinolines; Receptors, Neurokinin-3; Substance P | 2010 |
Three days after a single exposure to ozone, the mechanism of airway hyperreactivity is dependent on substance P and nerve growth factor.
Topics: Air Pollutants; Animals; Bronchial Hyperreactivity; Bronchoconstriction; Disease Models, Animal; Female; Guinea Pigs; Humans; Lung; Male; Models, Biological; Nerve Growth Factor; Neurokinin-1 Receptor Antagonists; Ozone; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Time Factors; Vagus Nerve | 2011 |
Substance P is a key mediator of stress-induced protection from allergic sensitization via modified antigen presentation.
Topics: Allergens; Animals; Antigen Presentation; Cells, Cultured; Coculture Techniques; Dendritic Cells; Dermatitis, Allergic Contact; Disease Models, Animal; Electric Stimulation; Female; Inflammation Mediators; Langerhans Cells; Mice; Mice, Inbred C57BL; Noise; Ovalbumin; Pilot Projects; Random Allocation; Stress, Physiological; Substance P | 2011 |
A substance P antagonist reduces axonal injury and improves neurologic outcome when administered up to 12 hours after traumatic brain injury.
Topics: Animals; Brain Edema; Brain Injuries; Diffuse Axonal Injury; Disease Models, Animal; Male; Neurokinin-1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Substance P; Treatment Outcome | 2011 |
Staphylococcal enterotoxin B causes proliferation of sensory C-fibers and subsequent enhancement of neurogenic inflammation in rat skin.
Topics: Animals; Anti-Inflammatory Agents; Brain-Derived Neurotrophic Factor; Capillary Permeability; Disease Models, Animal; Enterotoxins; Fluocinonide; Fluorescent Antibody Technique; Immunosuppressive Agents; Male; Nerve Fibers, Unmyelinated; Nerve Growth Factor; Neurogenic Inflammation; Rats; Receptors, Neurokinin-1; Skin; Specific Pathogen-Free Organisms; Substance P; Tacrolimus; TRPV Cation Channels; Tumor Necrosis Factor-alpha | 2011 |
Implication of Substance P in myocardial contractile function during ischemia in rats.
Topics: Animals; Diastole; Disease Models, Animal; Myocardial Contraction; Myocardial Ischemia; Myocardium; Rats; Rats, Sprague-Dawley; Substance P | 2011 |
Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia.
Topics: Androstadienes; Animals; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Formaldehyde; Gene Expression Regulation, Enzymologic; Hyperalgesia; Inflammation; Male; Nerve Tissue Proteins; Pain Measurement; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reaction Time; Signal Transduction; Sirolimus; Spinal Cord; Statistics, Nonparametric; Substance P; Time Factors; TOR Serine-Threonine Kinases; Wortmannin | 2011 |
Spatiotemporal CCR1, CCL3(MIP-1α), CXCR4, CXCL12(SDF-1α) expression patterns in a rat spinal cord injury model of posttraumatic neuropathic pain.
Topics: Animals; Biomarkers; Blotting, Western; Chemokine CCL3; Chemokine CXCL12; Disease Models, Animal; Immunohistochemistry; Male; Pain; Pain Threshold; Random Allocation; Rats; Receptors, Calcitonin Gene-Related Peptide; Receptors, CCR1; Receptors, CXCR4; Regression Analysis; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord Injuries; Substance P; TRPV Cation Channels | 2011 |
The reinnervation and revascularisation pattern of scarless murine fetal wounds.
Topics: Animals; Biomarkers; Calcitonin; Disease Models, Animal; Immunohistochemistry; Mice; Nerve Fibers; Protein Precursors; Regional Blood Flow; Skin; Substance P; Ubiquitin Thiolesterase; von Willebrand Factor; Wound Healing | 2011 |
A substance P antagonist improves outcome when administered 4 h after onset of ischaemic stroke.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Disease Models, Animal; Drug Administration Schedule; Infarction, Middle Cerebral Artery; Male; Neurokinin-1 Receptor Antagonists; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Recovery of Function; Substance P; Time Factors; Tryptophan | 2011 |
Cutaneous denervation of psoriasiform mouse skin improves acanthosis and inflammation in a sensory neuropeptide-dependent manner.
Topics: Animals; CD11c Antigen; CD4 Lymphocyte Count; Denervation; Disease Models, Animal; Ganglia, Spinal; Interleukin-23; Isoindoles; Keratinocytes; Mice; Neuropeptides; Peptide Fragments; Psoriasis; Receptor Protein-Tyrosine Kinases; Receptor, TIE-2; Receptors, Calcitonin Gene-Related Peptide; Skin; Substance P | 2011 |
Antipruritic effects of TRPV1 antagonist in murine atopic dermatitis and itching models.
Topics: Acrylamides; Animals; Antipruritics; Dermatitis, Atopic; Dermatophagoides farinae; Disease Models, Animal; Male; Mice; p-Methoxy-N-methylphenethylamine; Pyridines; Substance P; Th2 Cells; TRPV Cation Channels | 2011 |
The analgesic effects and mechanisms of orally administered eugenol.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Behavior, Animal; Brain; Disease Models, Animal; Eugenol; Glutamic Acid; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Receptors, Serotonin; Substance P | 2011 |
Proliferation of sensory C-fibers and subsequent neurogenic inflammation in rat airway induced by inhaled lipopolysaccharide.
Topics: Administration, Inhalation; Aerosols; Age Factors; Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Capillary Permeability; Cell Proliferation; Disease Models, Animal; Immunohistochemistry; Infliximab; Lipopolysaccharides; Male; Nerve Fibers, Unmyelinated; Nerve Growth Factor; Neurogenic Inflammation; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P; Time Factors; Trachea; Tumor Necrosis Factor-alpha | 2011 |
Endogenous substance P production in the Achilles tendon increases with loading in an in vivo model of tendinopathy-peptidergic elevation preceding tendinosis-like tissue changes.
Topics: Achilles Tendon; Animals; Disease Models, Animal; Female; Neuropeptides; Rabbits; Stress, Mechanical; Substance P; Tendinopathy; Up-Regulation; Weight-Bearing | 2011 |
TRPA1 and substance P mediate colitis in mice.
Topics: Aldehydes; Animals; Calcitonin Gene-Related Peptide; Calcium; Calcium Channels; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Diterpenes; Ganglia, Spinal; HEK293 Cells; Humans; Inflammation Mediators; Lipid Peroxidation; Membrane Potentials; Mice; Mice, Knockout; Mutation; Nerve Tissue Proteins; Patch-Clamp Techniques; Substance P; Transfection; Transient Receptor Potential Channels; Trinitrobenzenesulfonic Acid; TRPA1 Cation Channel; TRPV Cation Channels | 2011 |
A galenical of traditional Chinese herbal mixture (THC-002) reduces expression of tachykinin peptides within urethras of spontaneously hypertensive rats.
Topics: Aging; Animals; Disease Models, Animal; Drugs, Chinese Herbal; Hypertension; Male; Models, Animal; Neurokinin A; Neurokinin B; Rats; Rats, Inbred SHR; RNA, Messenger; Sodium Chloride; Substance P; Urethra | 2012 |
Potential mechanisms for hypoalgesia induced by anti-nerve growth factor immunoglobulin are identified using autoimmune nerve growth factor deprivation.
Topics: Age Factors; Animals; Antibodies, Monoclonal, Humanized; Calcitonin Gene-Related Peptide; Cytochromes c; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Ganglia, Spinal; Glycoproteins; Immunoglobulins; Inflammation; Male; NAV1.8 Voltage-Gated Sodium Channel; Nerve Growth Factor; Nerve Tissue Proteins; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Sodium Channels; Substance P | 2011 |
Determination of specific neuropeptides modulation time course in a rat model of osteoarthritis pain by liquid chromatography ion trap mass spectrometry.
Topics: Animals; Calcitonin Gene-Related Peptide; Chromatography, Liquid; Disease Models, Animal; Dynorphins; Enzyme Inhibitors; Humans; Iodoacetic Acid; Knee Joint; Male; Neuropeptides; Osteoarthritis; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Tandem Mass Spectrometry; Time Factors | 2011 |
Dopamine-dependent long-term depression is expressed in striatal spiny neurons of both direct and indirect pathways: implications for Parkinson's disease.
Topics: Analysis of Variance; Animals; Avoidance Learning; Biophysical Phenomena; Corpus Striatum; Disease Models, Animal; Dopamine; Electric Stimulation; Excitatory Postsynaptic Potentials; Exploratory Behavior; Green Fluorescent Proteins; Long-Term Synaptic Depression; Lysine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Neurons; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Dopamine D1; Receptors, Dopamine D2; Substance P | 2011 |
Carotid body remodelling in l-NAME-induced hypertension in the rat.
Topics: Animals; Biogenic Amines; Biomarkers; Blood Pressure; Carotid Body; Cell Nucleus; Disease Models, Animal; Enzyme Inhibitors; Fibrillar Collagens; Hypertension; Male; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Proteoglycans; Rats; Rats, Wistar; Substance P; Vascular Endothelial Growth Factor A | 2012 |
Neuroprotective effects of neurokinin receptor one in dopaminergic neurons are mediated through Akt/PKB cell signaling pathway.
Topics: Analysis of Variance; Animals; Apomorphine; bcl-Associated Death Protein; Caspase 3; Cell Death; Cell Line, Tumor; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dopaminergic Neurons; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gene Expression Regulation; L-Lactate Dehydrogenase; Male; Motor Activity; Neuroblastoma; Neurokinin-1 Receptor Antagonists; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidopamine; Peptide Fragments; Proto-Oncogene Proteins c-akt; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Rotarod Performance Test; Signal Transduction; Substance P; Sympatholytics; Time Factors; Tyrosine 3-Monooxygenase | 2011 |
Substance P induces adverse myocardial remodelling via a mechanism involving cardiac mast cells.
Topics: Animals; Apoptosis; Cell Degranulation; Collagen; Disease Models, Animal; Heart Failure; In Situ Nick-End Labeling; Male; Mast Cells; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Neurokinin A; Neurokinin-1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Time Factors; Tryptophan; Tumor Necrosis Factor-alpha; Ultrasonography; Ventricular Remodeling | 2011 |
Substance P in the corneal stroma regulates the severity of herpetic stromal keratitis lesions.
Topics: Analgesics; Animals; CD4-Positive T-Lymphocytes; Chemokine CCL3; Chemokine CXCL2; Corneal Stroma; Disease Models, Animal; Female; Herpesvirus 1, Human; Interleukin-6; Keratitis, Herpetic; Leukocyte Common Antigens; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Neutrophils; Receptors, Neurokinin-1; Severity of Illness Index; Substance P; Tubulin; Viral Load | 2011 |
The effects of OB-induced depression on nociceptive behaviors induced by electrical stimulation of the dura mater surrounding the superior sagittal sinus.
Topics: Amitriptyline; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Dura Mater; Electric Stimulation; Male; Migraine Disorders; Olfactory Bulb; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Substance P; Superior Sagittal Sinus | 2011 |
Effects of acupuncture and moxibustion in a mouse model of allergic rhinitis.
Topics: Acupuncture Therapy; Animals; Biomarkers; Disease Models, Animal; Female; Immunohistochemistry; Mice; Mice, Inbred BALB C; Moxibustion; Nasal Mucosa; NF-kappaB-Inducing Kinase; Nitric Oxide Synthase Type II; Protein Serine-Threonine Kinases; Rhinitis, Allergic, Perennial; STAT6 Transcription Factor; Substance P; Treatment Outcome | 2012 |
Suppressive effects of glycyrrhetinic acid derivatives on tachykinin receptor activation and hyperalgesia.
Topics: Analgesics; Animals; Calcium; Capsaicin; CHO Cells; Cricetinae; Disease Models, Animal; Formaldehyde; Glycyrrhetinic Acid; Hot Temperature; Humans; Hyperalgesia; Inflammation; Ligation; Male; Neuralgia; Neurokinin A; Neurokinin B; Pain; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Sciatic Nerve; Substance P | 2011 |
Abnormal development of intrinsic innervation in murine embryos with anorectal malformations.
Topics: Anal Canal; Animals; Digestive System Abnormalities; Disease Models, Animal; Disease Progression; Female; Immunohistochemistry; Mice; Myenteric Plexus; Pregnancy; Pregnancy, Animal; Proto-Oncogene Proteins c-kit; Substance P; Vasoactive Intestinal Peptide | 2012 |
Morphofunctional changes underlying intestinal dysmotility in diabetic RIP-I/hIFNβ transgenic mice.
Topics: Animals; Choline O-Acetyltransferase; Colon; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Disease Models, Animal; Gastric Emptying; Gastrointestinal Motility; Ileum; Interferon-beta; Male; Mice; Mice, Transgenic; Myenteric Plexus; Nitric Oxide Synthase Type I; Receptor-Interacting Protein Serine-Threonine Kinases; Streptozocin; Substance P; Vasoactive Intestinal Peptide | 2011 |
Changes of the vasculature and innervation in the anterior segment of the RCS rat eye.
Topics: Adrenergic Fibers; Age Factors; Aging; Animals; Anterior Eye Segment; Arterioles; Calcitonin Gene-Related Peptide; Capillaries; Dilatation, Pathologic; Disease Models, Animal; Iris; Microvessels; Nerve Fibers; Rats; Retinal Dystrophies; Substance P; Tyrosine 3-Monooxygenase; Venules | 2011 |
The proximodistal aggravation of colitis depends on substance P released from TRPV1-expressing sensory neurons.
Topics: Animals; Calcitonin Gene-Related Peptide; Colitis; Dextran Sulfate; Disease Models, Animal; Gene Expression Regulation; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; Sensory Receptor Cells; Severity of Illness Index; Substance P; TRPV Cation Channels | 2012 |
Immunohistochemical analysis of the effects of estrogen on intraarticular neurogenic inflammation in a rat anterior cruciate ligament transection model of osteoarthritis.
Topics: Animals; Anterior Cruciate Ligament; Anterior Cruciate Ligament Injuries; Biomarkers; Calcitonin Gene-Related Peptide; Disease Models, Animal; Estradiol; Estrogens; Female; Immunohistochemistry; Neurogenic Inflammation; Osteoarthritis, Knee; Ovariectomy; Rats; Rats, Wistar; Stifle; Substance P; Synovial Membrane; Ubiquitin Thiolesterase | 2012 |
Neurokinin-1 receptor deletion modulates behavioural and neurochemical alterations in an animal model of depression.
Topics: Animals; Biogenic Monoamines; Brain; Depression; Disease Models, Animal; Exploratory Behavior; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Olfactory Bulb; Receptors, Neurokinin-1; Substance P | 2012 |
Activation of NK₁ receptors in the locus coeruleus induces analgesia through noradrenergic-mediated descending inhibition in a rat model of neuropathic pain.
Topics: Adrenergic Neurons; Analgesia; Androstanes; Animals; Behavior, Animal; Benzimidazoles; Disease Models, Animal; Immunohistochemistry; Locus Coeruleus; Male; Neural Inhibition; Neuralgia; Neurokinin-1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P | 2012 |
Mast cells: source of inflammation in complex regional pain syndrome?
Topics: Animals; Complex Regional Pain Syndromes; Disease Models, Animal; Male; Mast Cells; Nociception; Substance P; Tibial Fractures | 2012 |
Substance P signaling controls mast cell activation, degranulation, and nociceptive sensitization in a rat fracture model of complex regional pain syndrome.
Topics: Animals; Complex Regional Pain Syndromes; Disease Models, Animal; Indoles; Male; Mast Cells; Neurokinin-1 Receptor Antagonists; Nociception; Pain Measurement; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Tibial Fractures | 2012 |
Substance P causes seizures in neurocysticercosis.
Topics: Animals; Brain; Brain Diseases; Disease Models, Animal; Female; Gene Deletion; Granuloma; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Neurocysticercosis; Neurokinin-1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Seizures; Substance P; Taenia | 2012 |
Nociceptive neuropeptide increases and periorbital allodynia in a model of traumatic brain injury.
Topics: Animals; Brain Injuries; Brain Stem; Calcitonin Gene-Related Peptide; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Headache; Hyperalgesia; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Neuropeptides; Nociception; Somatosensory Cortex; Substance P | 2012 |
Protective effect of transplanted bone marrow-derived mesenchymal stem cells on pancreatitis-associated lung injury in rats.
Topics: Acute Lung Injury; Amylases; Animals; Bone Marrow Cells; Disease Models, Animal; Enzyme Activation; Inflammation Mediators; Lung; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Pancreatitis; Peroxidase; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Severity of Illness Index; Substance P; Systemic Inflammatory Response Syndrome; Taurocholic Acid; Tumor Necrosis Factor-alpha | 2012 |
Inhibitory effect of botulinum toxin type A on the NANC system in rat respiratory models of neurogenic inflammation.
Topics: Animals; Arterial Occlusive Diseases; Botulinum Toxins, Type A; Brain Stem; Capsaicin; Disease Models, Animal; Lung; Male; Neurogenic Inflammation; Neurotransmitter Agents; Pneumonia; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Substance P; Synaptosomal-Associated Protein 25 | 2012 |
A substance P antagonist improves outcome in female Sprague Dawley rats following diffuse traumatic brain injury.
Topics: Animals; Brain Injuries; Disease Models, Animal; Female; Motor Activity; Rats; Rats, Sprague-Dawley; Substance P; Tryptophan | 2012 |
Targeting classical but not neurogenic inflammation reduces peritumoral oedema in secondary brain tumours.
Topics: Animals; Anti-Inflammatory Agents; Blood-Brain Barrier; Brain Edema; Brain Neoplasms; Dexamethasone; Disease Models, Animal; Inflammation; Male; Neurokinin-1 Receptor Antagonists; Rats; Rats, Wistar; Substance P | 2012 |
Secretoneurin, substance P and neuropeptide Y in the oxygen-induced retinopathy in C57Bl/6N mice.
Topics: Animals; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hyperoxia; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuropeptide Y; Neuropeptides; Radioimmunoassay; Retina; Retinal Neovascularization; Secretogranin II; Substance P | 2012 |
Involvement of Tyr1472 phosphorylation of NMDA receptor NR2B subunit in postherpetic neuralgia in model mice.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Ganglia, Spinal; Gene Expression Regulation; Gene Knock-In Techniques; Glial Cell Line-Derived Neurotrophic Factor; Herpes Simplex; Herpesvirus 1, Human; Male; Mice; Mice, Inbred C57BL; Mutant Proteins; N-Methylaspartate; Neuralgia, Postherpetic; Neurites; Neurotoxins; Phosphorylation; Phosphotyrosine; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Skin; Structure-Activity Relationship; Substance P | 2012 |
Antinociceptive effects of eugenol evaluated in a monoiodoacetate-induced osteoarthritis rat model.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Clove Oil; Disease Models, Animal; Dynorphins; Eugenol; Gait; Hyperalgesia; Iodoacetic Acid; Knee Joint; Male; Osteoarthritis; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 2012 |
De novo expression of neurokinin-1 receptors by spinoparabrachial lamina I pyramidal neurons following a peripheral nerve lesion.
Topics: Animals; Brachial Plexus; Brain Stem; Capsaicin; Cholera Toxin; Disease Models, Animal; Gene Expression Regulation; Hyperalgesia; Male; Microscopy, Confocal; Neural Pathways; Peripheral Nerve Injuries; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P | 2013 |
Substance P antagonist improves both obesity and asthma in a mouse model.
Topics: Allergens; Animals; Asthma; Biomarkers; Bronchial Hyperreactivity; Bronchitis; Disease Models, Animal; Mice; Neurokinin-1 Receptor Antagonists; Obesity; Substance P | 2013 |
Re-innervation patterns by peptidergic Substance-P, non-peptidergic P2X3, and myelinated NF-200 nerve fibers in epidermis and dermis of rats with neuropathic pain.
Topics: Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Dermis; Disease Models, Animal; Epidermis; Hyperalgesia; Langerhans Cells; Male; Nerve Fibers, Myelinated; Neuralgia; Neurofilament Proteins; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Reaction Time; Receptors, Purinergic P2X3; Substance P; Time Factors; Ubiquitin Thiolesterase | 2013 |
A new rat model of bone cancer pain produced by rat breast cancer cells implantation of the shaft of femur at the third trochanter level.
Topics: Animals; Behavior, Animal; Bone Neoplasms; Cell Line, Tumor; Disease Models, Animal; Female; Femur; Humans; Magnetic Resonance Imaging; Neoplasm Transplantation; Pain; Rats; Substance P; TRPV Cation Channels | 2013 |
Substance P induces gastric mucosal protection at supraspinal level via increasing the level of endomorphin-2 in rats.
Topics: Alcohols; Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Ethanol; Gastric Mucosa; Injections, Intraventricular; Male; Neurotransmitter Agents; Oligopeptides; Radioimmunoassay; Rats; Rats, Wistar; Stomach Ulcer; Substance P | 2013 |
Morphological analysis of skin in senescence-accelerated mouse P10.
Topics: Aging, Premature; Animals; Cell Division; Disease Models, Animal; Fibroblasts; Humans; Mast Cells; Mice; Mice, Mutant Strains; Microscopy, Electron; Microscopy, Immunoelectron; Skin; Skin Aging; Substance P | 2002 |
Sequential expression of the neuropeptides substance P and somatostatin in granulomas associated with murine cysticercosis.
Topics: Animals; Disease Models, Animal; Female; Gene Expression; Gene Expression Profiling; Granuloma; Mice; Mice, Inbred BALB C; Neurocysticercosis; RNA, Messenger; Somatostatin; Substance P; Taenia | 2002 |
Effects of corticosteroids on nerve root recovery after spinal nerve root compression.
Topics: Adrenal Cortex Hormones; Animals; Cats; CD4 Antigens; CD5 Antigens; Decompression, Surgical; Disease Models, Animal; Ganglia, Spinal; Pain, Postoperative; Radiculopathy; Spinal Nerve Roots; Substance P | 2002 |
Immune-mediated neural dysfunction in a murine model of chronic Helicobacter pylori infection.
Topics: Acetylcholine; Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Enteric Nervous System; Female; Gastritis; Helicobacter Infections; Helicobacter pylori; Immunohistochemistry; Macrophages; Mice; Mice, Inbred BALB C; Mice, SCID; Muscle Contraction; Specific Pathogen-Free Organisms; Spinal Cord; Stomach; Substance P; Vasoactive Intestinal Peptide | 2002 |
Interleukin-1beta-induced airway hyperresponsiveness enhances substance P in intrinsic neurons of ferret airway.
Topics: Acetylcholine; Animals; Bronchial Hyperreactivity; Disease Models, Animal; Electric Stimulation; Ferrets; Instillation, Drug; Interleukin-1; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Neurons; Substance P; Trachea | 2002 |
Effect of substance P injection into the nucleus tractus solitarius of rats on cricothyroid and thyroarytenoid motor activity and cardiovascular and respiratory systems.
Topics: Analysis of Variance; Animals; Apnea; Blood Pressure; Disease Models, Animal; Electromyography; Female; Heart Rate; Hypotension; Laryngeal Muscles; Laryngismus; Larynx; Male; Movement; Rats; Rats, Sprague-Dawley; Reflex; Respiration; Solitary Nucleus; Stereotaxic Techniques; Substance P | 2002 |
Three-dimensional mapping of sensory innervation with substance p in porcine bronchial mucosa: comparison with human airways.
Topics: Adult; Afferent Pathways; Aged; Animals; Bronchi; Disease Models, Animal; Female; Humans; Imaging, Three-Dimensional; Male; Middle Aged; Neurons, Afferent; Respiratory Mucosa; Substance P; Swine | 2002 |
[The changes in the morphology and distribution of substance P and calcitonin-gene related peptide nerves in the anterior pituitary of scalded rats].
Topics: Animals; Burns; Calcitonin Gene-Related Peptide; Disease Models, Animal; Female; Male; Nerve Fibers; Pituitary Gland, Anterior; Rats; Rats, Sprague-Dawley; Substance P | 2002 |
Endothelial dysfunction in murine model of systemic sclerosis: tight-skin mice 1.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Aorta, Thoracic; Bradykinin; Calcium; Disease Models, Animal; Endothelium, Vascular; Iloprost; In Vitro Techniques; Isometric Contraction; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microscopy, Confocal; Nitric Oxide; Nitric Oxide Synthase; Scleroderma, Systemic; Skin; Substance P; Vasodilation; Vasodilator Agents | 2002 |
Substance P gene expression in acute experimental colitis.
Topics: Acute Disease; Animals; Colitis; Colon; Disease Models, Animal; Formaldehyde; Ganglia, Spinal; Gene Expression Regulation; Muscle, Smooth; Rabbits; Substance P | 1995 |
Pan-neurotrophin receptor p75 contributes to neuronal hyperreactivity and airway inflammation in a murine model of experimental asthma.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Immunohistochemistry; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Growth Factors; Neurons; Ovalbumin; Receptor, Nerve Growth Factor; Receptors, Nerve Growth Factor; Respiratory System; Substance P | 2003 |
Bone cancer pain.
Topics: Animals; Biomarkers; Bone Neoplasms; Disease Models, Animal; Mice; Osteolysis; Pain; Sarcoma, Experimental; Spinal Cord; Substance P | 2003 |
Nociception in persistent pancreatitis in rats: effects of morphine and neuropeptide alterations.
Topics: Amylases; Analgesics, Opioid; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Immunohistochemistry; Lipase; Male; Morphine; Neuropeptides; Organotin Compounds; Pain; Pain Measurement; Pancreas; Pancreatitis; Physical Stimulation; Rats; Rats, Inbred Lew; Substance P | 2003 |
Differential changes in striatal projection neurons in R6/2 transgenic mice for Huntington's disease.
Topics: Age Factors; Animals; Autoradiography; Corpus Striatum; Disease Models, Animal; Enkephalins; Gene Expression; Genotype; Globus Pallidus; Huntington Disease; Immunohistochemistry; In Situ Hybridization; Mice; Mice, Transgenic; Neural Pathways; Neurons; Nucleus Accumbens; Protein Precursors; RNA, Messenger; Substance P; Substantia Nigra; Tachykinins | 2002 |
Mechanisms of transforming growth factor-alpha (TGF-alpha) induced gastroprotection against ethanol in the rat: roles of sensory neurons, sensory neuropeptides, and prostaglandins.
Topics: Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Ethanol; Gastric Mucosa; Gastritis; Indomethacin; Injections, Intraperitoneal; Male; Neurons, Afferent; Neuropeptides; Probability; Prostaglandins; Radionuclide Imaging; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; Sensitivity and Specificity; Stomach; Substance P; Transforming Growth Factor alpha | 2003 |
Striatal cell type-specific overexpression of DeltaFosB enhances incentive for cocaine.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Doxycycline; Drug Administration Schedule; Dynorphins; Gene Expression; Mice; Mice, Transgenic; Motivation; Neurons; Organ Specificity; Proto-Oncogene Proteins c-fos; Reinforcement, Psychology; Self Administration; Substance P; Transgenes | 2003 |
Long-term effects of decreased noradrenergic central nervous system innervation on pain behavior and opioid antinociception.
Topics: Analgesics, Opioid; Animals; Antibodies, Monoclonal; Behavior, Animal; Biphenyl Compounds; Central Nervous System; Denervation; Disease Models, Animal; Disease Progression; Female; Hyperalgesia; Immunohistochemistry; Immunotoxins; Injections, Intraventricular; Injections, Spinal; Lumbosacral Region; Male; Morphine; Norepinephrine; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Ribosome Inactivating Proteins, Type 1; Saporins; Spinal Cord; Substance P; Time | 2003 |
The effect of an intestinal ischemia-reperfusion injury on renal nerve activity among rats.
Topics: Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Efferent Pathways; Intestine, Small; Ischemia; Kidney; Male; Portal System; Rats; Rats, Wistar; Renal Circulation; Reperfusion Injury; Substance P | 2003 |
The algogenic-induced nociceptive flexion test in mice: studies on sensitivity of the test and stress on animals.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Bites and Stings; Bradykinin; Corticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Epoprostenol; Formaldehyde; Immobilization; Male; Mice; Pain; Pain Measurement; Peripheral Nervous System; Prostaglandins F; Reflex; Sensitivity and Specificity; Stress, Physiological; Substance P | 2003 |
Effect of intestinal inflammation on capsaicin-sensitive afferents in the ileum of Schistosoma mansoni-infected mice.
Topics: Animals; Animals, Newborn; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Enteric Nervous System; Fluorescent Antibody Technique, Indirect; Ganglia, Spinal; Ileum; Injections, Subcutaneous; Intestinal Mucosa; Male; Mast Cells; Mice; Neurons, Afferent; Nodose Ganglion; Parasitic Diseases, Animal; Receptors, Drug; Schistosomiasis mansoni; Substance P | 2003 |
Dietary magnesium intake influences circulating pro-inflammatory neuropeptide levels and loss of myocardial tolerance to postischemic stress.
Topics: Animals; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Enzyme-Linked Immunosorbent Assay; Erythrocytes; Glutathione; Hemodynamics; Magnesium; Magnesium Deficiency; Male; Malondialdehyde; Myocardial Ischemia; Myocardial Reperfusion Injury; Neurogenic Inflammation; Oxidative Stress; Rats; Rats, Sprague-Dawley; Spin Trapping; Substance P | 2003 |
Inhibitory effect of the repeated treatment with Unsei-in on substance P-induced itch-associated responses through the downregulation of the expression of NK(1) tachykinin receptor in mice.
Topics: Administration, Oral; Animals; Antipruritics; Disease Models, Animal; Down-Regulation; Drugs, Chinese Herbal; Injections, Intradermal; Male; Mice; Mice, Inbred ICR; Pruritus; Receptors, Neurokinin-1; Skin; Substance P | 2003 |
Restoration of corneal epithelial barrier function and wound healing by substance P and IGF-1 in rats with capsaicin-induced neurotrophic keratopathy.
Topics: Administration, Topical; Animals; Biological Transport; Capsaicin; Cornea; Corneal Diseases; Disease Models, Animal; Drug Therapy, Combination; Epithelium, Corneal; Female; Fluorescein; Fluorophotometry; Insulin-Like Growth Factor I; Male; Ophthalmic Solutions; Pregnancy; Rats; Rats, Wistar; Substance P; Tears; Trigeminal Nerve Diseases; Wound Healing | 2003 |
Effects of substance P and IGF-1 in corneal epithelial barrier function and wound healing in a rat model of neurotrophic keratopathy.
Topics: Animals; Biological Transport; Cell Membrane Permeability; Corneal Diseases; Cranial Nerve Diseases; Denervation; Disease Models, Animal; Drug Therapy, Combination; Epithelium, Corneal; Fluorescein; Fluorophotometry; Insulin-Like Growth Factor I; Male; Ophthalmic Nerve; Ophthalmic Solutions; Rats; Rats, Inbred BN; Substance P; Tears; Wound Healing | 2003 |
Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Formaldehyde; Hyperalgesia; Imidazoles; Inflammation; Injections, Spinal; Isoenzymes; Male; Microglia; Mitogen-Activated Protein Kinases; Neuralgia; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pain Threshold; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 2003 |
Spinal upregulation of the nitric oxide synthase-interacting protein NOSIP in a rat model of inflammatory pain.
Topics: Animals; Carrier Proteins; Disease Models, Animal; Freund's Adjuvant; Functional Laterality; Ganglia, Spinal; Hindlimb; Immunohistochemistry; Inflammation; Injections; Lectins; Male; Pain; Pain Measurement; Phosphopyruvate Hydratase; Rats; Rats, Wistar; Spinal Cord; Substance P; Time Factors; Ubiquitin-Protein Ligases; Up-Regulation | 2003 |
Airway eosinophil accumulation on sensory neuropeptide release in a guinea pig model of distilled-water-induced bronchoconstriction.
Topics: Aerosols; Animals; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Disease Models, Animal; Eosinophils; Guinea Pigs; Immunization, Passive; Male; Methacholine Chloride; Piperidines; Platelet Activating Factor; Quinuclidines; Substance P; Water | 2003 |
Substance P regulates Th1-type colitis in IL-10 knockout mice.
Topics: Animals; Cells, Cultured; Chronic Disease; Colitis; Disease Models, Animal; Interleukin-10; Interleukin-12; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurokinin-1 Receptor Antagonists; Piroxicam; Receptors, Neurokinin-1; RNA, Messenger; Substance P; Th1 Cells | 2003 |
The influence of inflammation on the expression of neuropeptides in the ileum-projecting primary sensory neurones in the pig.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Dyes; Formaldehyde; Galanin; Ganglia, Spinal; Ileitis; Ileum; Neurons, Afferent; Neuropeptide Y; Neuropeptides; Polymers; Somatostatin; Substance P; Sus scrofa; Thoracic Vertebrae; Up-Regulation; Vasoactive Intestinal Peptide; Visceral Afferents | 2003 |
MafB deficiency causes defective respiratory rhythmogenesis and fatal central apnea at birth.
Topics: Action Potentials; Afferent Pathways; Animals; Animals, Newborn; Avian Proteins; Biomarkers; Disease Models, Animal; DNA-Binding Proteins; Electric Stimulation; Fetus; Homeodomain Proteins; MafB Transcription Factor; Mice; Mice, Knockout; Nerve Net; Neurons; Oncogene Proteins; Organ Culture Techniques; Periodicity; Receptors, Neurokinin-1; Respiration; Respiratory Center; Sleep Apnea, Central; Substance P; Transcription Factors | 2003 |
Neuropeptides concentrations in the skin of a murine (NC/Nga mice) model of atopic dermatitis.
Topics: Animals; Back; Calcitonin Gene-Related Peptide; Dermatitis, Atopic; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunoglobulin E; Immunohistochemistry; Mice; Mice, Inbred Strains; Osmolar Concentration; Skin; Species Specificity; Staining and Labeling; Substance P | 2003 |
Role of sensory nerve peptides rather than mast cell histamine in paclitaxel hypersensitivity.
Topics: Analysis of Variance; Animals; Biopsy, Needle; Bronchoalveolar Lavage Fluid; Calcitonin Gene-Related Peptide; Disease Models, Animal; Drug Hypersensitivity; Histamine; Immunohistochemistry; Infusions, Intravenous; Male; Mast Cells; Neurokinin A; Neuropeptides; Paclitaxel; Probability; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Sensory Receptor Cells; Substance P | 2004 |
The influence of experimental Bacteroides fragilis infection on substance P and somatostatin-immunoreactive neural elements in the porcine ascending colon - a preliminary report.
Topics: Animals; Bacteroides fragilis; Bacteroides Infections; Colitis; Colon, Ascending; Disease Models, Animal; Female; Fluorescent Antibody Technique, Indirect; Myenteric Plexus; Nerve Fibers; Neurons; Somatostatin; Submucous Plexus; Substance P; Swine | 2003 |
Substance P immunoreactive nerve fibres in the domestic chick ankle joint before and after acute urate arthritis.
Topics: Animals; Arthralgia; Arthritis; Chickens; Disease Models, Animal; Down-Regulation; Female; Gout; Immunohistochemistry; Male; Nerve Fibers; Nociceptors; Sensory Receptor Cells; Substance P; Synovial Membrane; Tarsal Joints; Uric Acid | 2004 |
Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I.
Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Formaldehyde; Hot Temperature; Hyperalgesia; Inflammation; Mice; Mice, Knockout; Neurons; Pain; Reaction Time; Substance P; Thionucleotides | 2004 |
Can lesions of GPe correct HD deficits?
Topics: Animals; Disease Models, Animal; Enkephalins; gamma-Aminobutyric Acid; Globus Pallidus; Humans; Huntington Disease; Substance P | 2004 |
Nociceptin inhibits airway microvascular leakage induced by HCl intra-oesophageal instillation.
Topics: Animals; Benzimidazoles; Bronchi; Capillary Permeability; Disease Models, Animal; Gastroesophageal Reflux; Guinea Pigs; Hydrochloric Acid; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nociceptin; Opioid Peptides; Piperidines; Receptors, Opioid; Substance P; Trachea; Vagotomy; Vasodilator Agents | 2004 |
Retargeted clostridial endopeptidases: inhibition of nociceptive neurotransmitter release in vitro, and antinociceptive activity in in vivo models of pain.
Topics: Action Potentials; Animals; Botulinum Toxins, Type A; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Embryo, Mammalian; Endopeptidases; Ganglia, Spinal; Glycine; Immunotoxins; In Vitro Techniques; Membrane Proteins; Mice; Nerve Fibers, Unmyelinated; Nerve Tissue Proteins; Neuromuscular Agents; Neurons; Neurotransmitter Agents; Pain; Pain Measurement; Reaction Time; Spinal Cord; Substance P; Synaptic Transmission; Synaptosomal-Associated Protein 25; Time Factors | 2004 |
Constitutive spinal cyclooxygenase-2 participates in the initiation of tissue injury-induced hyperalgesia.
Topics: Animals; Blotting, Western; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Hindlimb; Hyperalgesia; Immunohistochemistry; Injections, Spinal; Isoenzymes; Lumbosacral Region; Male; N-Methylaspartate; Neuroglia; Neurons; Physical Stimulation; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Up-Regulation | 2004 |
Role of substance P in an NC/Nga mouse model of atopic dermatitis-like disease.
Topics: Animals; Dermatitis, Atopic; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eosinophils; Immunoglobulin E; Immunohistochemistry; Interleukin-4; Male; Mast Cells; Mice; Picryl Chloride; Statistics, Nonparametric; Substance P | 2004 |
Role of capsaicin-sensitive afferent nerves in different models of gastric inflammation in rats.
Topics: Animals; Biomarkers; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Denervation; Disease Models, Animal; Gastric Mucosa; Gastritis; Inflammation Mediators; Male; Malondialdehyde; Neurokinin-1 Receptor Antagonists; Neurotoxins; Peroxidase; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Receptors, Neuropeptide; Sensory Receptor Cells; Substance P; Visceral Afferents | 2004 |
Involvement of peripherally released substance P and calcitonin gene-related peptide in mediating mechanical hyperalgesia in a traumatic neuropathy model of the rat.
Topics: Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Functional Laterality; Hyperalgesia; Lumbosacral Region; Male; Pain Measurement; Pain Threshold; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Rhizotomy; Spinal Cord Injuries; Statistics, Nonparametric; Substance P; Time Factors | 2004 |
Substance P signaling contributes to the vascular and nociceptive abnormalities observed in a tibial fracture rat model of complex regional pain syndrome type I.
Topics: Animals; Body Temperature; Bone Diseases, Metabolic; Casts, Surgical; Disease Models, Animal; Edema; Hindlimb; Indoles; Male; Nociceptors; Piperidines; Rats; Rats, Sprague-Dawley; Reflex Sympathetic Dystrophy; Signal Transduction; Substance P; Tibial Fractures | 2004 |
Hypoxic response in newborn rat is attenuated by neurokinin-1 receptor blockade.
Topics: Analgesics; Animals; Animals, Newborn; Brain Stem; Disease Models, Animal; Female; Hypoxia; Indoles; Injections, Intraventricular; Isoindoles; Male; Medulla Oblongata; Neurokinin-1 Receptor Antagonists; Proto-Oncogene Proteins c-fos; Pulmonary Ventilation; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Respiration; Respiratory Mechanics; RNA, Messenger; Substance P | 2004 |
Spinal neurons involved in the generation of at-level pain following spinal injury in the rat.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Grooming; Immunohistochemistry; Immunotoxins; N-Glycosyl Hydrolases; Neurotoxins; Pain; Plant Proteins; Posterior Horn Cells; Rats; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Self Mutilation; Skin; Spinal Cord; Spinal Cord Injuries; Substance P | 2004 |
Involvement of substance P in scratching behaviour in an atopic dermatitis model.
Topics: Animals; Behavior, Animal; Dermatitis, Atopic; Disease Models, Animal; Male; Mice; Neurokinin-1 Receptor Antagonists; Pruritus; Receptors, Neurokinin-1; Substance P; Tachykinins | 2004 |
N-methyl-D-aspartate receptor blockade inhibits cardiac inflammation in the Mg2+-deficient rat.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fluorescent Antibody Technique; Heart Diseases; Inflammation; Intercellular Adhesion Molecule-1; Magnesium Deficiency; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stress, Physiological; Substance P | 2004 |
Effects of tegaserod on Fos, substance P and calcitonin gene-related peptide expression induced by colon inflammation in lumbarsacral spinal cord.
Topics: Animals; Calcitonin Gene-Related Peptide; Colitis; Disease Models, Animal; Gastrointestinal Agents; Indoles; Male; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Visceral Afferents | 2004 |
Substance P and neurotensin are up-regulated in the lumbar spinal cord of animals with neuropathic pain.
Topics: Animals; Constriction; Disease Models, Animal; Electrophysiology; Hindlimb; Lumbar Vertebrae; Male; Neurotensin; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord; Substance P; Up-Regulation | 2004 |
Substance P and neutral endopeptidase in development of acute respiratory distress syndrome following fire smoke inhalation.
Topics: Animals; Blood Gas Analysis; Disease Models, Animal; Fires; Humans; Kinetics; Neprilysin; Rats; Rats, Inbred F344; Respiratory Distress Syndrome; Smoke; Substance P; Time Factors | 2004 |
Greater involvement of neurokinins found in Guinea pig models of severe asthma compared with mild asthma.
Topics: Administration, Inhalation; Airway Resistance; Allergens; Animals; Asthma; Biomarkers; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Capsaicin; Disease Models, Animal; Eosinophils; Guinea Pigs; Lung; Male; Methacholine Chloride; Neprilysin; Neurokinin A; Respiratory Hypersensitivity; Severity of Illness Index; Substance P | 2004 |
The role of the tachykinin NK1 receptor in airway changes in a mouse model of allergic asthma.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophilia; Immunoglobulin E; Lung; Mice; Mice, Knockout; Ovalbumin; Receptors, Neurokinin-1; Substance P | 2004 |
Partial sciatic nerve transection causes redistribution of pain-related peptides and lowers withdrawal threshold.
Topics: Animals; Disease Models, Animal; Female; Ganglia, Spinal; Lumbosacral Region; Neuropeptides; Pain; Pain Measurement; Pain Threshold; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Somatostatin; Substance P | 2004 |
Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: an expanded convergent functional genomics approach.
Topics: Animals; Antimanic Agents; Bayes Theorem; Bipolar Disorder; Brain; Central Nervous System Stimulants; Disease Models, Animal; Dopamine and cAMP-Regulated Phosphoprotein 32; Enkephalins; Gene Expression Profiling; Genetic Linkage; Genetic Predisposition to Disease; Genetic Testing; Genomics; Humans; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Microarray Analysis; Nerve Tissue Proteins; Pharmacogenetics; Phosphoproteins; Protein Precursors; Substance P; Tachykinins; Valproic Acid | 2004 |
Involvement of enhanced neurokinin NK3 receptor expression in the severe asthma guinea pig model.
Topics: Animals; Asthma; Benzamides; Binding, Competitive; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophils; Guinea Pigs; Lung; Male; Methacholine Chloride; Neurokinin B; Ovalbumin; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Substance P; Tritium | 2004 |
Depletion of mucosal substance P in acute otitis media.
Topics: Acute Disease; Animals; Bone Resorption; Disease Models, Animal; Male; Mucous Membrane; Otitis Media; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Substance P; Time Factors | 2004 |
Regulation of dopamine receptor and neuropeptide expression in the basal ganglia of monkeys treated with MPTP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Basal Ganglia; Disease Models, Animal; Dopamine; Down-Regulation; Enkephalins; Female; Functional Laterality; Globus Pallidus; Macaca mulatta; Neostriatum; Neuropeptides; Parkinsonian Disorders; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Substance P; Substantia Nigra; Up-Regulation | 2004 |
Nervous system development in normal and atresic chick embryo intestine: an immunohistochemical study.
Topics: Animals; Axons; Cell Proliferation; Chick Embryo; Disease Models, Animal; Enteric Nervous System; Growth Inhibitors; Immunohistochemistry; Intestinal Atresia; Intestines; Muscle, Smooth; Substance P; Vasoactive Intestinal Peptide | 2004 |
Neuropeptide substance P stimulates the formation of osteoclasts via synovial fibroblastic cells.
Topics: Animals; Disease Models, Animal; Fibroblasts; Glycoproteins; Immunohistochemistry; Ligands; Neuropeptides; NF-kappa B; Osteoclasts; Osteogenesis; Osteoprotegerin; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Neurokinin-1; Receptors, Tumor Necrosis Factor; Reverse Transcriptase Polymerase Chain Reaction; Substance P; Synovial Fluid | 2005 |
Pathways for the bradykinin B1 receptor-mediated diabetic hyperalgesia in mice.
Topics: Animals; Bradykinin B1 Receptor Antagonists; Calcitonin Gene-Related Peptide; Diabetes Mellitus, Experimental; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Male; Mice; Nitric Oxide Synthase; Receptor, Bradykinin B1; Signal Transduction; Streptozocin; Substance P | 2004 |
Effect of lumbar nerve root compression on primary sensory neurons and their central branches: changes in the nociceptive neuropeptides substance P and somatostatin.
Topics: Animals; Axonal Transport; Biomarkers; Cell Count; Disease Models, Animal; Dogs; Ganglia, Spinal; Image Processing, Computer-Assisted; Immunoenzyme Techniques; Lumbar Vertebrae; Nerve Compression Syndromes; Posterior Horn Cells; Radiculopathy; Somatostatin; Substance P | 2005 |
Neuropeptide expression in rats exposed to chronic mild stresses.
Topics: Amygdala; Animals; Arcuate Nucleus of Hypothalamus; Brain; Brain Mapping; Chronic Disease; Dentate Gyrus; Depressive Disorder, Major; Disease Models, Animal; Galanin; Gene Expression Regulation; Hypothalamus; Male; Neuropeptide Y; Neuropeptides; Rats; Rats, Wistar; RNA, Messenger; Self Stimulation; Stress, Psychological; Substance P | 2005 |
Change of dorsal horn neurochemistry in a mouse model of neuropathic cancer pain.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Male; Mice; Mice, Inbred BALB C; Neoplasms; Pain; Peripheral Nervous System Diseases; Posterior Horn Cells; Substance P | 2005 |
The antidepressant effect of running is associated with increased hippocampal cell proliferation.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Body Weight; Brain-Derived Neurotrophic Factor; Bromodeoxyuridine; Cell Count; Cell Proliferation; Depression; Disease Models, Animal; Dynorphins; Enkephalins; Freezing Reaction, Cataleptic; Hippocampus; Immunohistochemistry; In Situ Hybridization; Male; Rats; Rats, Inbred Strains; RNA, Messenger; Running; Substance P | 2005 |
Exogenous administration of Substance P enhances wound healing in a novel skin-injury model.
Topics: Animals; Disease Models, Animal; Immunohistochemistry; Injections, Subcutaneous; Integrin alpha5beta1; Intercellular Adhesion Molecule-1; Lasers; Male; Neurites; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Skin; Skin Physiological Phenomena; Substance P; Time Factors; Wound Healing | 2005 |
Cannabinoid CB(1) receptors in the basal ganglia and motor response to activation or blockade of these receptors in parkin-null mice.
Topics: Analysis of Variance; Animals; Basal Ganglia; Disease Models, Animal; Enkephalins; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Parkinsonian Disorders; Protein Precursors; Receptor, Cannabinoid, CB1; RNA, Messenger; Sex Factors; Statistics, Nonparametric; Substance P; Superoxide Dismutase; Tyrosine 3-Monooxygenase; Ubiquitin-Protein Ligases | 2005 |
Substance P does not play a critical role in neurogenic inflammation in the rat masseter muscle.
Topics: Analgesics; Animals; Capsaicin; Disease Models, Animal; Edema; Inflammation Mediators; Male; Masseter Muscle; Mustard Plant; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Plant Extracts; Plant Oils; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P | 2005 |
Will corticosteroids and other anti-inflammatory agents be effective for diarrhea-predominant irritable bowel syndrome?
Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Budesonide; Cyclooxygenase 2; Cytokines; Diarrhea; Dinoprostone; Disease Models, Animal; Humans; Irritable Bowel Syndrome; Lymphocyte Activation; Membrane Proteins; Mice; Models, Biological; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Substance P; T-Lymphocytes; Trichinella spiralis; Trichinellosis | 2005 |
[Experimental study on the relationship between neuropeptide substance P and wound healing in scalded rats].
Topics: Animals; Burns; Cell Proliferation; Disease Models, Animal; Female; Fibroblasts; Male; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P; Wound Healing | 2005 |
Involvement of phosphorylated extracellular signal-regulated kinase in the mouse substance P pain model.
Topics: Animals; Brain; Dentate Gyrus; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Immunohistochemistry; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinase 3; Pain; Pain Measurement; Paraventricular Hypothalamic Nucleus; Phosphorylation; Posterior Horn Cells; Spinal Cord; Substance P | 2005 |
Substance P inhibits progesterone conversion to neuroactive metabolites in spinal sensory circuit: a potential component of nociception.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Male; Models, Neurological; Neurons, Afferent; Nociceptors; Pain; Progesterone; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 2005 |
Allergic airway inflammation induces tachykinin peptides expression in vagal sensory neurons innervating mouse airways.
Topics: Allergens; Animals; Bronchoalveolar Lavage Fluid; Cell Differentiation; Disease Models, Animal; Female; Immunohistochemistry; Leukocyte Count; Mice; Mice, Inbred BALB C; Neurokinin A; Neurons, Afferent; Ovalbumin; Respiratory Hypersensitivity; Substance P; Tachykinins; Vagus Nerve | 2005 |
Pretreatment with antiserum against dynorphin, substance P, or cholecystokinin enhances the morphine-produced anti-allodynia in the sciatic nerve ligated mice.
Topics: Analgesics, Opioid; Animals; Antibodies; Cholecystokinin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Dynorphins; Immune Sera; Injections, Spinal; Ligation; Male; Mice; Morphine; Neuralgia; Peripheral Nervous System Diseases; Sciatic Nerve; Sciatic Neuropathy; Substance P | 2005 |
Substance-P-mediated immunomodulation of tumor growth in a murine model.
Topics: Adoptive Transfer; Animals; Cell Proliferation; Disease Models, Animal; Immunologic Factors; Infusion Pumps; Killer Cells, Natural; Melanoma; Mice; Mice, Inbred C3H; Mice, Nude; Mice, SCID; Neuroimmunomodulation; Substance P; T-Lymphocytes; Tumor Burden | 2005 |
Functional role of prostacyclin receptor in rat dorsal root ganglion neurons.
Topics: Animals; Animals, Newborn; Capsaicin; Cells, Cultured; Cyclic AMP; Cystitis, Interstitial; Disease Models, Animal; Female; Ganglia, Spinal; Iloprost; Inflammation Mediators; Membrane Potentials; Neurons, Afferent; Nociceptors; Pain; Potassium Chloride; Prostaglandins; Rats; Rats, Sprague-Dawley; Receptors, Epoprostenol; Substance P; Vasodilator Agents | 2005 |
TRPV1 activation results in disruption of the blood-brain barrier in the rat.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Capillaries; Capillary Permeability; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Male; Microspheres; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Starch; Substance P; Tetrazoles; Time Factors; TRPV Cation Channels | 2005 |
Molecular and behavioral changes in nociception in a novel rat model of chronic pancreatitis for the study of pain.
Topics: Amylases; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Radiation; Electric Stimulation; Enzyme-Linked Immunosorbent Assay; Ganglia, Spinal; Gene Expression Regulation; Immunohistochemistry; Male; Nerve Growth Factor; Nociceptors; Pain; Pain Measurement; Pancreatitis; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Time Factors; Trinitrobenzenesulfonic Acid | 2005 |
Sleep-disordered breathing after targeted ablation of preBötzinger complex neurons.
Topics: Animals; Cell Death; Disease Models, Animal; Electroencephalography; Electromyography; Immunohistochemistry; Immunotoxins; Neurons; Polysomnography; Rats; Receptors, Neurokinin-1; Respiratory Center; Ribosome Inactivating Proteins, Type 1; Saporins; Sleep Apnea Syndromes; Sleep, REM; Substance P; Time Factors; Wakefulness | 2005 |
Antipruritic effect of ginsenoside rb1 and compound k in scratching behavior mouse models.
Topics: Animals; Antipruritics; Behavior, Animal; Capillary Permeability; Disease Models, Animal; Ginsenosides; Histamine; Inhibitory Concentration 50; Male; Mice; p-Methoxy-N-methylphenethylamine; Phthalazines; Pruritus; Substance P; Time Factors | 2005 |
Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin.
Topics: Action Potentials; Amines; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Cell Count; Cell Death; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Functional Laterality; Gabapentin; gamma-Aminobutyric Acid; Gene Expression Regulation; Hot Temperature; Immunohistochemistry; Male; Neurons; Ondansetron; Pain; Pain Measurement; Pain Threshold; Pokeweed Mitogens; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Serotonin; Serotonin Antagonists; Spinal Cord; Substance P; Time Factors | 2005 |
Regional differences in gastrointestinal motility disturbances during acute necrotising pancreatitis.
Topics: Acute Disease; Animals; Carbachol; Choline Deficiency; Dietary Supplements; Dinoprost; Disease Models, Animal; Ethionine; Female; Gastric Emptying; Gastrointestinal Motility; In Vitro Techniques; Mice; Muscle Contraction; Muscle, Smooth; Pancreatitis, Acute Necrotizing; Substance P | 2005 |
Exogenously administered substance P and neutral endopeptidase inhibitors stimulate fibroblast proliferation, angiogenesis and collagen organization during Achilles tendon healing.
Topics: Achilles Tendon; Animals; Captopril; Cell Proliferation; Collagen; Disease Models, Animal; Drug Combinations; Fibroblasts; Male; Neovascularization, Physiologic; Neprilysin; Protease Inhibitors; Random Allocation; Rats; Rats, Sprague-Dawley; Rupture; Substance P; Tendon Injuries; Thiorphan; Treatment Outcome; Wound Healing | 2005 |
Remodelling of spinal nociceptive mechanisms in an animal model of monoarthritis.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ankle; Arthritis; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Agonists; Freund's Adjuvant; Functional Laterality; Immunohistochemistry; Iontophoresis; Male; Microscopy, Immunoelectron; N-Methylaspartate; Neuronal Plasticity; Neurons; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P; Time Factors | 2005 |
Possible mechanism of referred pain in the perineum and pelvis associated with the prostate in rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Fluorescence; Ganglia, Spinal; Immunohistochemistry; Male; Neurotransmitter Agents; Pelvic Pain; Perineum; Prostate; Rats; Rats, Wistar; Substance P; Vasodilator Agents | 2005 |
Motor-skill learning-associated gene regulation in the striatum: effects of cocaine.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Disease Models, Animal; Dopamine; Dynorphins; Enkephalins; Gene Expression Regulation; Learning; Male; Motor Activity; Motor Skills; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Substance P; Up-Regulation | 2006 |
NF-kappaB activation precedes increases in mRNA encoding neurokinin-1 receptor, proinflammatory cytokines, and adhesion molecules in dextran sulfate sodium-induced colitis in rats.
Topics: Analysis of Variance; Animals; Base Sequence; Biopsy, Needle; Colitis; Cytokines; Dextran Sulfate; Disease Models, Animal; Immunohistochemistry; Inflammation Mediators; Male; Molecular Sequence Data; NF-kappa B; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sensitivity and Specificity; Substance P | 2005 |
HSV-1-mediated NGF delivery delays nociceptive deficits in a genetic model of diabetic neuropathy.
Topics: Action Potentials; Age Factors; Animals; Behavior, Animal; Blotting, Northern; Cell Count; Diabetic Nephropathies; Disease Models, Animal; Dose-Response Relationship, Radiation; Electric Stimulation; Ganglia, Spinal; Genetic Therapy; Genetic Vectors; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Nerve Fibers; Nerve Growth Factors; Pain Measurement; Reaction Time; Receptor, Nerve Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simplexvirus; Substance P | 2006 |
Genetic manipulation of intraspinal plasticity after spinal cord injury alters the severity of autonomic dysreflexia.
Topics: Adenoviridae; Afferent Pathways; Animals; Autonomic Dysreflexia; Autonomic Fibers, Preganglionic; Axons; Bradycardia; Calcitonin Gene-Related Peptide; Colon; Cordotomy; Dilatation, Pathologic; Disease Models, Animal; Female; Genetic Therapy; Genetic Vectors; Hypertension; Microinjections; Nerve Growth Factor; Neuronal Plasticity; Pain; Posterior Horn Cells; Rats; Rats, Wistar; Recombinant Fusion Proteins; Rectum; Semaphorin-3A; Spinal Cord Injuries; Substance P; Vasoconstriction | 2006 |
Regional variations in neurokinin receptor subtype contributions to muscularis mucosae and epithelial function in rat colon.
Topics: Acetylcholine; Animals; Colon; Disease Models, Animal; Female; Gastrointestinal Motility; Intestinal Mucosa; Male; Muscle, Smooth; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Sensitivity and Specificity; Substance P; Tissue Culture Techniques | 2006 |
[Changes in substance P in myocardium and dorsal root ganglion following coronary artery occlusion in rats].
Topics: Animals; Coronary Vessels; Disease Models, Animal; Ganglia, Spinal; Ligation; Male; Myocardial Ischemia; Myocardium; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance P | 2006 |
Characterization of three different sensory fibers by use of neonatal capsaicin treatment, spinal antagonism and a novel electrical stimulation-induced paw flexion test.
Topics: Animals; Animals, Newborn; Capsaicin; Disease Models, Animal; Electric Stimulation; Foot; Hindlimb; Male; Mice; Nerve Fibers, Unmyelinated; Neurokinin-1 Receptor Antagonists; Neuronal Plasticity; Neurons, Afferent; Nociceptors; Pain; Pain Measurement; Pain Threshold; Peripheral Nerve Injuries; Peripheral Nerves; Predictive Value of Tests; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Reflex; Spinal Nerve Roots; Substance P; Synaptic Transmission | 2006 |
Upregulation of substance P receptor expression by calcitonin gene-related peptide, a possible cooperative action of two neuropeptides involved in airway inflammation.
Topics: Animals; Asthma; Blotting, Western; Bronchial Hyperreactivity; Calcitonin Gene-Related Peptide; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Guinea Pigs; Humans; Inflammation; Lung; Ozone; Protein-Tyrosine Kinases; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Substance P; Up-Regulation | 2007 |
Calcitonin gene-related peptide and substance P regulate the intestinal radiation response.
Topics: Adenosine; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Disease Models, Animal; Gene Expression Profiling; Intestines; Male; Multivariate Analysis; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Radiation Injuries, Experimental; Rats; Rats, Sprague-Dawley; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; Substance P; X-Rays | 2006 |
Upregulation of tumor necrosis factor-alpha by stress and substance p in a murine model of allergic airway inflammation.
Topics: Acoustic Stimulation; Animals; Asthma; CD3 Complex; Disease Models, Animal; Interferon-gamma; Interleukin-4; Lung; Lymph Nodes; Lymphocyte Count; Mice; Mice, Inbred BALB C; Neuroimmunomodulation; Sound; Stress, Physiological; Substance P; T-Lymphocytes; Tumor Necrosis Factor-alpha; Up-Regulation | 2006 |
The reinnervation pattern of wounds and scars may explain their sensory symptoms.
Topics: Animals; Calcitonin Gene-Related Peptide; Cicatrix; Contracture; Disease Models, Animal; Male; Mice; Mice, Inbred Strains; Nerve Fibers; Nerve Regeneration; Regeneration; Regional Blood Flow; Sensation Disorders; Skin; Substance P; Wound Healing | 2006 |
[Study on the sense neuropeptides of nasal mucosa in the allergic rhinitis animal model].
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Nasal Mucosa; Neuropeptides; Rabbits; Rhinitis, Allergic, Perennial; Substance P | 2006 |
Substance P receptor mediated maintenance of chronic inflammation in EAE.
Topics: Animals; Anti-Inflammatory Agents; CD4-Positive T-Lymphocytes; Chronic Disease; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Encephalomyelitis, Autoimmune, Experimental; Female; Immunity, Cellular; Immunosuppression Therapy; Interferon-gamma; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Myelin Proteins; Myelin-Associated Glycoprotein; Myelin-Oligodendrocyte Glycoprotein; Neuroimmunomodulation; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Substance P | 2006 |
Mechanical allodynia and thermal hyperalgesia induced by experimental squamous cell carcinoma of the lower gingiva in rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Carcinoma, Squamous Cell; Cell Line, Tumor; Disease Models, Animal; Gingiva; Hot Temperature; Hyperalgesia; Immunohistochemistry; Male; Mouth Mucosa; Mouth Neoplasms; Neurons, Afferent; Nociceptors; Physical Stimulation; Rats; Rats, Inbred F344; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Substance P; Trigeminal Ganglion; Trigeminal Nerve; TRPV Cation Channels | 2006 |
Evidence of anti-inflammatory effects of Passiflora edulis in an inflammation model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Carrageenan; Disease Models, Animal; Female; Histamine; Inflammation; Interleukin-1beta; Leukocytes; Male; Mice; Nitric Oxide; Passiflora; Peroxidase; Phytotherapy; Plant Extracts; Pleurisy; Substance P; Tumor Necrosis Factor-alpha | 2007 |
Beneficial effect of tachykinin NK1 receptor antagonism in the development of hapten-induced colitis in mice.
Topics: Animals; Capillary Permeability; Colitis; Colon; Diarrhea; Dinitrofluorobenzene; Disease Models, Animal; Haptens; Hypersensitivity; Indoles; Isoindoles; Male; Mast Cells; Mice; Mice, Inbred BALB C; Neurokinin-1 Receptor Antagonists; Substance P; Sulfonic Acids | 2006 |
The effect of substance P on nitric oxide release in a rheumatoid arthritis model.
Topics: Aged; Animals; Arthritis, Rheumatoid; Cells, Cultured; Disease Models, Animal; Female; Gene Expression Regulation; Humans; Inflammation; Interleukin-1beta; Mice; Mice, Knockout; Middle Aged; Neurotransmitter Agents; Nitrates; Nitric Oxide; Nitrites; Receptors, Neurokinin-1; Substance P; Synovial Membrane; Tumor Necrosis Factor-alpha | 2006 |
Airway hyper-responsiveness in allergic asthma in guinea-pigs is mediated by nerve growth factor via the induction of substance P: a potential role for trkA.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Carbazoles; Disease Models, Animal; Enzyme Inhibitors; Female; Guinea Pigs; Immunohistochemistry; Indole Alkaloids; Lung; Male; Nerve Growth Factor; Neurons; Nodose Ganglion; Ovalbumin; Receptor, trkA; Signal Transduction; Substance P; Tyrphostins | 2006 |
Changes in the neuronal activity in the pedunculopontine nucleus in chronic MPTP-treated primates: an in situ hybridization study of cytochrome oxidase subunit I, choline acetyl transferase and substance P mRNA expression.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acetylcholine; Animals; Biomarkers; Choline O-Acetyltransferase; Cholinergic Fibers; Disease Models, Animal; Down-Regulation; Electron Transport Complex IV; Female; In Situ Hybridization; Macaca fascicularis; Neurons; Neurotoxins; Parkinsonian Disorders; Pedunculopontine Tegmental Nucleus; Protein Subunits; RNA, Messenger; Substance P | 2007 |
[Experimental study on the mechanisms of regulating airway neurogenic inflammation in asthma by never growth factor and leukemia inhibitory factor].
Topics: Animals; Asthma; Disease Models, Animal; Ganglia, Spinal; Leukemia Inhibitory Factor; Lung; Male; Nerve Growth Factor; Neurogenic Inflammation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance P | 2006 |
Alternation of substance P-containing neural pathways in a rat model of irritable bowel syndrome with rectal distension.
Topics: Animals; Biomarkers; Central Nervous System; Disease Models, Animal; Intestine, Large; Irritable Bowel Syndrome; Male; Neural Pathways; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Substance P | 2006 |
[Effect of nociceptin on histamine and serotonin release in the central nervous system].
Topics: Animals; Disease Models, Animal; Hippocampus; Histamine; Histamine Release; Hypothalamus; Pain; Rats; Rats, Wistar; Serotonin; Substance P | 2006 |
Changes in pain behavior induced by formalin, substance P, glutamate and pro-inflammatory cytokines in immobilization-induced stress mouse model.
Topics: Analgesia; Animals; Behavior, Animal; Cytokines; Disease Models, Animal; Glutamic Acid; Inflammation Mediators; Male; Mice; Mice, Inbred ICR; Nociceptors; Pain; Pain Measurement; Pain Threshold; Restraint, Physical; Stress, Psychological; Substance P | 2006 |
Anti-catabolic effect of OP-1 in chronically compressed intervertebral discs.
Topics: Animals; Antibodies; Biomechanical Phenomena; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Disease Models, Animal; Endopeptidases; Interleukin-1beta; Intervertebral Disc; Intervertebral Disc Displacement; Male; Matrix Metalloproteinase 13; Rats; Rats, Sprague-Dawley; Substance P; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2007 |
Spantide I decreases type I cytokines, enhances IL-10, and reduces corneal perforation in susceptible mice after Pseudomonas aeruginosa infection.
Topics: Animals; Chemotaxis, Leukocyte; Cornea; Corneal Ulcer; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eye Infections, Bacterial; Female; Immunoenzyme Techniques; Interleukin-10; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neutrophils; Peroxidase; Pseudomonas aeruginosa; Pseudomonas Infections; Reverse Transcriptase Polymerase Chain Reaction; Rupture, Spontaneous; Substance P | 2007 |
Sensory neuron and substance P involvement in symptoms of a zymosan-induced rat model of acute bowel inflammation.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Colitis; Colon; Disease Models, Animal; Enteric Nervous System; Ethanol; Inflammation Mediators; Male; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Oligonucleotides, Antisense; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; RNA, Messenger; Substance P; Sympathetic Nervous System; Zymosan | 2007 |
Assessment of antidepressant and anxiolytic properties of NK1 antagonists and substance P in Wistar Kyoto rats.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Exploratory Behavior; Hypothalamus; Male; Rats; Rats, Inbred WKY; Rats, Wistar; Substance P; Swimming | 2007 |
Contributions of histamine, prostanoids, and neurokinins to edema elicited by edema toxin from Bacillus anthracis.
Topics: Animals; Antigens, Bacterial; Aprepitant; Bacillus anthracis; Bacterial Toxins; Capillary Permeability; Celecoxib; Cell Degranulation; Cell Line; Disease Models, Animal; Edema; Enzyme Inhibitors; Histamine; Histamine H1 Antagonists; Humans; Indomethacin; Injections, Intradermal; Mast Cells; Morpholines; Neurokinin-1 Receptor Antagonists; Prostaglandin Antagonists; Prostaglandins; Pyrazoles; Pyrilamine; Rabbits; Substance P; Sulfonamides; Tachykinins | 2007 |
Substance P as an immunomodulatory neuropeptide in a mouse model for autoimmune hair loss (alopecia areata).
Topics: Alopecia Areata; Animals; Autoimmune Diseases; CD8-Positive T-Lymphocytes; Cell Degranulation; Disease Models, Animal; Gene Expression; Granzymes; Hair Follicle; Immunologic Factors; Mast Cells; Mice; Mice, Inbred C3H; Neprilysin; Nerve Fibers; Receptors, Neurokinin-1; Signal Transduction; Substance P | 2007 |
Effects of decompression on neuropathic pain behaviors and skin reinnervation in chronic constriction injury.
Topics: Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Decompression, Surgical; Disease Models, Animal; Foot; Functional Laterality; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Skin; Substance P; Time Factors; Ubiquitin Thiolesterase | 2007 |
Adjuvant neuropeptides can improve neuropathic ligament healing in a rat model.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Female; Femoral Nerve; Ligaments; Neuropeptide Y; Neuropeptides; Peripheral Nervous System Diseases; Rats; Rats, Wistar; Rupture; Substance P; Sympathectomy; Vasoactive Intestinal Peptide; Wound Healing | 2007 |
Upregulation of substance P in low-threshold myelinated afferents is not required for tactile allodynia in the chronic constriction injury and spinal nerve ligation models.
Topics: Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Constriction, Pathologic; Denervation; Disease Models, Animal; Electric Stimulation; Hyperesthesia; Ligation; Male; Medulla Oblongata; Nerve Fibers, Myelinated; Neurons, Afferent; Pain; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-1; Sciatic Nerve; Sensory Thresholds; Spinal Cord; Spinal Cord Injuries; Spinal Nerves; Substance P; Time Factors; Up-Regulation | 2007 |
Involvement of substance P and calcitonin gene-related peptide in development and maintenance of neuropathic pain from spinal nerve injury model of rat.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Disease Models, Animal; Dose-Response Relationship, Drug; Lidocaine; Male; Neuralgia; Pain Measurement; Peptide Fragments; Quinuclidines; Rats; Rats, Sprague-Dawley; Spinal Nerves; Substance P; Time Factors | 2007 |
Bradykinin- and substance P-induced edema formation in the hamster cheek pouch is tyrosine kinase dependent.
Topics: Animals; Bradykinin; Capillary Permeability; Cheek; Cricetinae; Dextrans; Disease Models, Animal; Edema; Fluorescein-5-isothiocyanate; Genistein; Male; Mesocricetus; Microcirculation; Microscopy, Video; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Signal Transduction; Substance P; Tyrphostins | 2007 |
Early dexamethasone treatment after implantation of a sciatic-nerve cuff decreases the concentration of substance P in the lumbar spinal cord of rats with neuropathic pain.
Topics: Animals; Anti-Inflammatory Agents; Calcitonin; Cholecystokinin; Chromatography, Liquid; Constriction; Dexamethasone; Disease Models, Animal; Male; Mass Spectrometry; Nerve Fibers; Neurotensin; Random Allocation; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sciatic Neuropathy; Spinal Cord; Substance P; Time Factors; Treatment Outcome | 2007 |
Chronic inflammation alters the contribution of neurokinin receptor subtypes to epithelial function in rat colon.
Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Benzamides; Colitis; Disease Models, Animal; Indomethacin; Intestinal Mucosa; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Stereoisomerism; Substance P; Tetrodotoxin; Trinitrobenzenesulfonic Acid | 2008 |
Dietary pulverized konjac glucomannan suppresses scratching behavior and skin inflammatory immune responses in NC/Nga mice.
Topics: Animals; Dermatitis, Atopic; Dietary Carbohydrates; Disease Models, Animal; Ear; Eosinophilia; Immunoglobulin E; Immunoglobulin G; Interferon-alpha; Interleukin-10; Interleukin-4; Keratosis; Male; Mannans; Mastocytosis, Cutaneous; Mice; Mice, Inbred Strains; Pruritus; Skin; Substance P | 2007 |
The effect of restraint stress on the normal colon and on intestinal inflammation in a model of experimental colitis.
Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Colitis; Colon; Disease Models, Animal; Female; Intestinal Mucosa; Malondialdehyde; Oxidative Stress; Radioimmunoassay; Rats; Restraint, Physical; Severity of Illness Index; Stress, Physiological; Substance P; Trinitrobenzenesulfonic Acid | 2008 |
Differential role of N-type calcium channel splice isoforms in pain.
Topics: Alternative Splicing; Analysis of Variance; Animals; Animals, Newborn; Calcium Channels, N-Type; Cells, Cultured; Disease Models, Animal; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Ganglia, Spinal; Hyperalgesia; Membrane Potentials; Neuralgia; Neurons, Afferent; Pain Measurement; Pain Threshold; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Substance P | 2007 |
Spinal mechanisms of antinociceptive action caused by diphenyl diselenide.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzene Derivatives; Bradykinin; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Inhibitory Concentration 50; Interleukin-1beta; Male; Mice; Organoselenium Compounds; Pain; Pain Measurement; Spinal Cord; Substance P; Tumor Necrosis Factor-alpha | 2007 |
A neurokinin-1 receptor antagonist that reduces intra-abdominal adhesion formation decreases oxidative stress in the peritoneum.
Topics: Animals; Antioxidants; Bridged Bicyclo Compounds, Heterocyclic; Dinoprost; Disease Models, Animal; Gastrointestinal Agents; Intercellular Adhesion Molecule-1; Laparotomy; Male; NADPH Oxidases; Neurokinin-1 Receptor Antagonists; Neutrophil Infiltration; Oxidative Stress; Peritoneal Diseases; Peritoneum; Peroxidase; Protein Carbonylation; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Neurokinin-1; RNA, Messenger; Substance P; Time Factors; Tissue Adhesions; Vascular Cell Adhesion Molecule-1 | 2007 |
Implication of dipeptidylpeptidase IV activity in human bronchial inflammation and in bronchoconstriction evaluated in anesthetized rabbits.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Animals; Biomarkers; Bronchial Hyperreactivity; Bronchitis, Chronic; Bronchoconstriction; Dipeptidyl Peptidase 4; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Histamine; Humans; Immunohistochemistry; Male; Middle Aged; Nasal Mucosa; Probability; Rabbits; Reference Values; Sampling Studies; Sensitivity and Specificity; Severity of Illness Index; Substance P | 2008 |
Neuronal plasticity of the "brain-skin connection": stress-triggered up-regulation of neuropeptides in dorsal root ganglia and skin via nerve growth factor-dependent pathways.
Topics: Animals; Antibodies; Calcitonin Gene-Related Peptide; Dermis; Disease Models, Animal; Ganglia, Spinal; Injections, Intradermal; Male; Mice; Mice, Inbred C57BL; Nerve Growth Factor; Neuronal Plasticity; Neuropeptides; Noise; Signal Transduction; Skin Diseases; Stress, Psychological; Substance P; Up-Regulation | 2007 |
Effect of reflux-induced inflammation on transient receptor potential vanilloid one (TRPV1) expression in primary sensory neurons innervating the oesophagus of rats.
Topics: Animals; Disease Models, Animal; Esophagus; Ganglia, Spinal; Gastroesophageal Reflux; Immunohistochemistry; Male; Neurons, Afferent; Nodose Ganglion; Plant Lectins; Rats; Rats, Sprague-Dawley; Substance P; TRPV Cation Channels | 2007 |
Continuous intra-arterial application of substance P induces signs and symptoms of experimental complex regional pain syndrome (CRPS) such as edema, inflammation and mechanical pain but no thermal pain.
Topics: Animals; Chemotaxis, Leukocyte; Complex Regional Pain Syndromes; Disease Models, Animal; Edema; Endothelial Cells; Hyperalgesia; Hypesthesia; Infusion Pumps, Implantable; Injections, Intra-Arterial; Male; Microcirculation; Neurogenic Inflammation; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Substance P | 2007 |
Anti-inflammatory evaluation of Solidago chilensis Meyen in a murine model of pleurisy.
Topics: Adenosine Deaminase; Animals; Anti-Inflammatory Agents; Bradykinin; Butanols; Carrageenan; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Flowers; Histamine; Inflammation; Interleukin-1beta; Leukocytes, Mononuclear; Male; Mice; Neutrophils; Peroxidase; Plant Extracts; Plant Leaves; Pleurisy; Rhizome; Solidago; Substance P; Tumor Necrosis Factor-alpha | 2007 |
A transient unresponsive state of self-scratching behaviour is induced in mice by skin-scratching stimulation.
Topics: Analgesics, Non-Narcotic; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Male; Mice; Mice, Inbred ICR; Peptide Fragments; Physical Stimulation; Pruritus; Quinuclidines; Self Stimulation; Signal Transduction; Skin Physiological Phenomena; Substance P | 2007 |
[Expression of substance P in intestinal tissue and the relation between substance P and mucosa permeability in acute necrotizing pancreatitis in rat].
Topics: Animals; Disease Models, Animal; Intestinal Mucosa; Pancreatitis, Acute Necrotizing; Permeability; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance P | 2007 |
The effect of high cervical spinal cord stimulation on the expression of SP, NK-1 and TRPV1 mRNAs during cardiac ischemia in rat.
Topics: Animals; Brain Stem; Disease Models, Animal; Electric Stimulation; Gene Expression Regulation; Male; Myocardial Ischemia; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; RNA, Messenger; Spinal Cord; Substance P; TRPV Cation Channels | 2007 |
Inflammation and inflammatory agents activate protein kinase C epsilon translocation and excite guinea-pig submucosal neurons.
Topics: Action Potentials; Animals; Blotting, Western; Calbindin 2; Cell Membrane; Cytoplasm; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Guinea Pigs; Ileitis; Ileum; In Vitro Techniques; Inflammation Mediators; Kinetics; Neuropeptide Y; Oligopeptides; Peptide Fragments; Phorbol 12,13-Dibutyrate; Protein Kinase C-epsilon; Protein Transport; Receptor, PAR-2; Receptors, Neurokinin-3; S100 Calcium Binding Protein G; Signal Transduction; Submucous Plexus; Substance P; Trinitrobenzenesulfonic Acid; Trypsin; Vasoactive Intestinal Peptide | 2007 |
Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease.
Topics: Adenoviridae; Animals; Brain-Derived Neurotrophic Factor; Carrier Proteins; Disease Models, Animal; Disease Progression; Enkephalins; Globus Pallidus; Huntington Disease; Mice; Mice, Transgenic; Mitosis; Neostriatum; Neurons; Regeneration; Substance P; Tubulin | 2007 |
Ghrelin inhibits sympathetic nervous activity in sepsis.
Topics: Animals; Arginine; Disease Models, Animal; Ghrelin; Injections, Intravenous; Injections, Intraventricular; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Ghrelin; Receptors, Neuropeptide Y; Sepsis; Signal Transduction; Substance P; Sympathetic Nervous System; Tumor Necrosis Factor-alpha | 2007 |
Are neuropeptides important in arthritis? Studies on the importance of bombesin/GRP and substance P in a murine arthritis model.
Topics: Animals; Arthritis; Bombesin; Disease Models, Animal; Gastrin-Releasing Peptide; Male; Mice; Neuropeptides; Substance P | 2007 |
The "brain-skin connection": nerve growth factor-dependent pathways for stress-induced skin disorders.
Topics: Animals; Brain; Calcitonin Gene-Related Peptide; Dermis; Disease Models, Animal; Ganglia, Spinal; Humans; Injections, Intradermal; Mice; Nerve Growth Factor; Neuronal Plasticity; Neuropeptides; Noise; Signal Transduction; Skin Diseases; Stress, Psychological; Substance P; Up-Regulation | 2007 |
Transient cervical nerve root compression modulates pain: load thresholds for allodynia and sustained changes in spinal neuropeptide expression.
Topics: Animals; Calcitonin Gene-Related Peptide; Compressive Strength; Disease Models, Animal; Gene Expression Regulation; Humans; Neck Pain; Nerve Compression Syndromes; Rats; Substance P | 2008 |
Effects of substance P on neuronal firing of pallidal neurons in parkinsonian rats.
Topics: Action Potentials; Adrenergic Agents; Analysis of Variance; Animals; Behavior, Animal; Compulsive Behavior; Disease Models, Animal; Drug Interactions; Globus Pallidus; Male; Medial Forebrain Bundle; Neurons; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Substance P; Tropanes | 2008 |
The differential effects of emotional or physical stress on pain behaviors or on c-Fos immunoreactivity in paraventricular nucleus or arcuate nucleus.
Topics: Analysis of Variance; Animals; Arcuate Nucleus of Hypothalamus; Chronic Disease; Disease Models, Animal; Glutamic Acid; Immunohistochemistry; Injections, Spinal; Interferon-gamma; Interleukin-1beta; Male; Mice; Mice, Inbred ICR; Pain; Pain Threshold; Paraventricular Hypothalamic Nucleus; Proto-Oncogene Proteins c-fos; Statistics, Nonparametric; Stress, Psychological; Substance P; Tumor Necrosis Factor-alpha | 2008 |
Substance P is associated with heart enlargement and apoptosis in murine dilated cardiomyopathy induced by Taenia crassiceps infection.
Topics: Animals; Apoptosis; Cardiomegaly; Cardiomyopathy, Dilated; Cysticercosis; Disease Models, Animal; Female; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Neurotransmitter Agents; Substance P; Taenia; Taeniasis | 2007 |
Differential corticosterone responses to stress in the lung in two strains of Flinders rats.
Topics: Animals; Cell Degranulation; Corticosterone; Corticotropin-Releasing Hormone; Diffusion Chambers, Culture; Disease Models, Animal; Electrophysiology; Epithelium; Mast Cells; Microscopy, Electron; Organ Culture Techniques; Rats; Rats, Inbred Strains; Species Specificity; Stress, Psychological; Substance P; Trachea | 2008 |
Pharmacological characterization of T-2328, 2-fluoro-4'-methoxy-3'-[[[(2S,3S)-2-phenyl-3-piperidinyl]amino]methyl]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride, as a brain-penetrating antagonist of tachykinin NK1 receptor.
Topics: Animals; Antiemetics; Antineoplastic Agents; Aprepitant; Binding Sites; Brain; Cell Line, Tumor; CHO Cells; Cisplatin; Cricetinae; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Ferrets; Gerbillinae; Humans; Kinetics; Male; Morpholines; Motor Activity; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Substance P; Transfection; Vomiting | 2008 |
Enhancement of cutaneous nerve regeneration by 4-methylcatechol in resiniferatoxin-induced neuropathy.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Catechols; Disease Models, Animal; Diterpenes; Drug Interactions; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Nerve Fibers, Unmyelinated; Nerve Regeneration; Neural Conduction; Neuroprotective Agents; Peripheral Nervous System Diseases; Reaction Time; Skin; Substance P; Ubiquitin Thiolesterase | 2008 |
A new model of laryngitis: neuropeptide, cyclooxygenase, and cytokine profile.
Topics: Animals; Calcitonin Gene-Related Peptide; Cyclooxygenase 1; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Inflammation Mediators; Interleukin-10; Interleukin-1beta; Interleukin-6; Intubation, Gastrointestinal; Laryngeal Mucosa; Laryngitis; Male; Membrane Proteins; Neurons, Afferent; Neuropeptides; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Substance P; Time Factors; Tumor Necrosis Factor-alpha | 2008 |
Spinal subarachnoid adrenal medullary transplants reduce hind paw swelling and peripheral nerve transport following formalin injection in rats.
Topics: Adrenal Medulla; Afferent Pathways; Animals; Axonal Transport; Chromaffin Cells; Disease Models, Animal; GAP-43 Protein; Immunohistochemistry; Inflammation; Ligation; Male; Neurons, Afferent; Pain Measurement; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Substance P | 2008 |
Experimental study of cardiorespiratory and stress factors in esophageal surgery using robot-assisted thoracoscopic or open thoracic approach.
Topics: Anastomosis, Surgical; Animals; Blood Gas Analysis; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Esophagectomy; Female; Hemodynamics; Male; Minimally Invasive Surgical Procedures; Monitoring, Intraoperative; Oxidative Stress; Probability; Pulmonary Circulation; Pulmonary Gas Exchange; Random Allocation; Robotics; Sensitivity and Specificity; Substance P; Swine; Thoracic Surgery, Video-Assisted; Thoracotomy | 2008 |
Anti-inflammatory role of sympathetic nerves in chronic intestinal inflammation.
Topics: Adult; Aged; Aged, 80 and over; Animals; Colitis; Colon; Crohn Disease; Dextran Sulfate; Disease Models, Animal; Diverticulitis, Colonic; Female; Humans; Interferon-gamma; Interleukin-10; Lymph Nodes; Male; Mesentery; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Middle Aged; Nerve Fibers; Substance P; Sympathetic Nervous System; Tumor Necrosis Factor-alpha | 2008 |
Immediate electrical stimulation enhances regeneration and reinnervation and modulates spinal plastic changes after sciatic nerve injury and repair.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Electric Stimulation; Electromyography; Evoked Potentials, Motor; Female; Hyperalgesia; Lectins; Nerve Regeneration; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Reaction Time; Recovery of Function; Reflex; Sciatic Neuropathy; Spinal Cord; Substance P; Time Factors | 2008 |
Substance P as a novel anti-obesity target.
Topics: Adiposity; Animals; Anti-Obesity Agents; Appetite Regulation; Blood Glucose; Body Weight; Bridged Bicyclo Compounds, Heterocyclic; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Energy Metabolism; Feeding Behavior; Injections, Intraperitoneal; Insulin; Leptin; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Neurokinin-1 Receptor Antagonists; Obesity; Receptors, Neurokinin-1; Substance P; Time Factors | 2008 |
Synapse involvement of the dorsal horn in experimental lumbar nerve root compression: a light and electron microscopic study.
Topics: Animals; Anterior Horn Cells; Calcitonin Gene-Related Peptide; Disease Models, Animal; Dogs; Immunoenzyme Techniques; Lumbar Vertebrae; Microscopy, Electron; Nerve Compression Syndromes; Radiculopathy; Retrograde Degeneration; Somatostatin; Spinal Nerve Roots; Statistics, Nonparametric; Substance P | 2008 |
Neurokinin B/NK3 receptors exert feedback inhibition on L-DOPA actions in the 6-OHDA lesion rat model of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Autoradiography; Behavior, Animal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cocaine; Disease Models, Animal; Dopamine; Feedback; Functional Laterality; Gene Expression Regulation; Levodopa; Oxidopamine; Parkinson Disease; Peptide Fragments; Quinolines; Radioisotopes; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Serine; Substance P; Sympatholytics; Tyrosine 3-Monooxygenase | 2008 |
Utilization of the least shrew as a rapid and selective screening model for the antiemetic potential and brain penetration of substance P and NK1 receptor antagonists.
Topics: Animals; Antiemetics; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enteric Nervous System; Neurokinin-1 Receptor Antagonists; Oncogene Proteins v-fos; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Recombinant Fusion Proteins; Ribosome Inactivating Proteins, Type 1; Saporins; Shrews; Stereotyped Behavior; Substance P; Time Factors; Tissue Distribution; Vomiting | 2008 |
Peptidergic nerves in the ureter.
Topics: Animals; Disease Models, Animal; Immunohistochemistry; Male; Muscle, Smooth; Neurons; Substance P; Swine; Ureter; Ureteral Obstruction; Vasoactive Intestinal Peptide | 1993 |
Protective function of extrinsic sensory neurons in acute rabbit experimental colitis.
Topics: Animals; Blotting, Northern; Calcitonin Gene-Related Peptide; Capsaicin; Colitis; Colon; Disease Models, Animal; Intestinal Mucosa; Male; Necrosis; Neurons, Afferent; Rabbits; Radioimmunoassay; Substance P; Time Factors | 1994 |
Activity at phencyclidine and mu opioid sites mediates the hyperalgesic and antinociceptive properties of the N-terminus of substance P in a model of visceral pain.
Topics: Animals; Biological Assay; Disease Models, Animal; Dizocilpine Maleate; Hyperalgesia; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Peptide Fragments; Phencyclidine; Receptors, Opioid, mu; Spinal Cord; Substance P | 1994 |
Neonatal capsaicin treatment in rats results in scratching behavior with skin damage: potential model of non-painful dysesthesia.
Topics: Animals; Animals, Newborn; Behavior, Animal; Capsaicin; Disease Models, Animal; Injections, Spinal; Injections, Subcutaneous; Male; Morphine; Naloxone; Nerve Fibers; Rats; Rats, Sprague-Dawley; Self Mutilation; Skin; Substance P | 1994 |
Inhibition of hind-paw edema and cutaneous vascular plasma extravasation in mice by acetylshikonin.
Topics: Adrenalectomy; Animals; Anthraquinones; Bradykinin; Capillary Permeability; Cell Degranulation; Dexamethasone; Diphenhydramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drugs, Chinese Herbal; Edema; Glucuronidase; Glycogen; Hindlimb; Histamine; Indomethacin; Liver; Mast Cells; Methysergide; Mice; p-Methoxy-N-methylphenethylamine; Polymyxin B; Substance P | 1995 |
Characterization of thermal hyperalgesia, c-fos expression, and alterations in neuropeptides after mechanical irritation of the dorsal root ganglion.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Immunohistochemistry; Lumbar Vertebrae; Male; Neuropeptides; Proto-Oncogene Proteins c-fos; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Sciatica; Substance P | 1995 |
Increased levels of substance P and calcitonin gene-related peptide in rat adjuvant arthritis. A combined immunohistochemical and radioimmunoassay analysis.
Topics: Animals; Ankle Joint; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Chromatography, High Pressure Liquid; Disease Models, Animal; Female; Ganglia, Spinal; Immunohistochemistry; Microscopy, Fluorescence; Radioimmunoassay; Rats; Rats, Inbred Lew; Skin; Substance P; Synovial Membrane | 1995 |
Neuropeptide changes in compressed spinal nerve roots.
Topics: Animals; Chronic Disease; Disease Models, Animal; Female; Ganglia, Spinal; Male; Nerve Compression Syndromes; Spinal Nerve Roots; Substance P; Swine; Vasoactive Intestinal Peptide | 1995 |
Antiatherosclerotic effects of oral naftidrofuryl in cholesterol-fed rabbits involve inhibition of neutrophil function.
Topics: Acetylcholine; Administration, Oral; Animals; Aorta, Abdominal; Aorta, Thoracic; Arteriosclerosis; Cholesterol; Cholesterol, Dietary; Disease Models, Animal; Endothelium, Vascular; Fibrinogen; Luminescent Measurements; Luminol; Male; Molsidomine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nafronyl; Neutrophils; Nitric Oxide; Rabbits; Random Allocation; Substance P; Vasodilator Agents; Zymosan | 1995 |
Involvement of substance P in pial arteriolar vasodilatation during pneumococcal meningitis in the rat.
Topics: Animals; Arteries; Calcitonin Gene-Related Peptide; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Spinal; Male; Meningitis, Pneumococcal; Rats; Rats, Wistar; Substance P; Time Factors; Vasodilation | 1995 |
Inhibition by actinomycin D of neurogenic mouse ear oedema.
Topics: Animals; Bradykinin; Calcimycin; Calcitonin Gene-Related Peptide; Capsaicin; Cycloheximide; Dactinomycin; Disease Models, Animal; Dose-Response Relationship, Drug; Doxorubicin; Ear Diseases; Edema; Histamine; Injections, Intravenous; Leukotriene C4; Male; Mast Cells; Mice; p-Methoxy-N-methylphenethylamine; Platelet Activating Factor; Rats; Rats, Wistar; Serotonin; Substance P; Tachykinins; Vasoactive Intestinal Peptide | 1995 |
Potentiation by hypoxia of contractions caused by angiotensin II in dog and monkey cerebral arteries.
Topics: Angiotensin II; Animals; Cerebral Arteries; Constriction, Pathologic; Cyclooxygenase Inhibitors; Dinoprost; Disease Models, Animal; Dogs; Endothelium, Vascular; Female; Hypoxia; Macaca; Male; Substance P | 1993 |
Effects of topical capsaicin on autonomic nerves in experimentally-induced nasal hypersensitivity. An immunocytochemical study.
Topics: Administration, Intranasal; Animals; Autonomic Nervous System; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Female; Guinea Pigs; Nasal Mucosa; Olfactory Bulb; Rhinitis, Allergic, Perennial; Substance P; Toluene 2,4-Diisocyanate; Tyrosine 3-Monooxygenase | 1993 |
The ganglioside GM1 decreases autotomy but not substance P depletion in a peripheral mononeuropathy rat model.
Topics: Animals; Behavior, Animal; Disease Models, Animal; G(M1) Ganglioside; Male; Pain; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Self Mutilation; Spinal Cord; Substance P | 1993 |
Substance P in cutaneous primary sensory neurons--a comparison of models of nerve injury that allow varying degrees of regeneration.
Topics: Amputation Stumps; Anastomosis, Surgical; Animals; Cell Death; Disease Models, Animal; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Female; Fluorescent Dyes; Ganglia, Spinal; Nerve Crush; Nerve Regeneration; Neurons, Afferent; Pain Measurement; Peripheral Nerve Injuries; Peripheral Nerves; Rats; Skin; Stilbamidines; Substance P; Sural Nerve | 1993 |
Neuropeptide modulation of chemically induced skin irritation.
Topics: Administration, Cutaneous; Animals; Benzamides; Biphenyl Compounds; Capsaicin; Dermatitis, Contact; Dinitrofluorobenzene; Disease Models, Animal; Dose-Response Relationship, Drug; Ear, External; Female; Irritants; Mice; Mice, Inbred BALB C; Neurokinin A; Neuropeptides; Piperidines; Skin; Substance P; Synaptic Transmission | 1995 |
Substance P content and preprotachykinin gene-I mRNA expression in a rat model of chronic bronchitis.
Topics: Animals; Base Sequence; Bronchitis; Chronic Disease; Disease Models, Animal; Ganglia, Spinal; Gene Expression; Lung; Molecular Sequence Data; Nodose Ganglion; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance P; Sulfur Dioxide; Tachykinins; Trachea | 1996 |
Role of interleukin-5 and substance P in development of airway hyperreactivity to histamine in guinea-pigs.
Topics: Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cells, Cultured; Disease Models, Animal; Drug Interactions; Eosinophils; Guinea Pigs; Histamine; Interleukin-5; Male; Peroxidase; Substance P; Trachea | 1996 |
Effect of the tachykinin receptor antagonists, SR 140333, FK 888, and SR 142801, on capsaicin-induced mouse ear oedema.
Topics: Animals; Binding Sites; Capsaicin; Dipeptides; Disease Models, Animal; Ear Diseases; Edema; Indoles; Injections, Intravenous; Lethal Dose 50; Male; Mice; Piperidines; Quinuclidines; Receptors, Tachykinin; Skin; Stereoisomerism; Structure-Activity Relationship; Substance P | 1996 |
A model for experimental induction of acute temporomandibular joint inflammation in rats: effects of substance P(SP) on neuropeptide-like immunoreactivity.
Topics: Animals; Calcitonin Gene-Related Peptide; Chromatography, High Pressure Liquid; Disease Models, Animal; Inflammation; Male; Neurokinin A; Neuropeptide Y; Neuropeptides; Rats; Rats, Sprague-Dawley; Substance P; Temporomandibular Joint; Temporomandibular Joint Disorders | 1996 |
[Experimental techniques for developing new drugs acting on dementia (10)--Alzheimer's disease animal model induced by beta-amyloid protein].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Atrophy; Brain; Choline O-Acetyltransferase; Disease Models, Animal; Male; Microtubule Proteins; Neurotransmitter Agents; Rats; Rats, Wistar; Substance P | 1996 |
Role of substance P and neurokinin A in toluene diisocyanate-induced increased airway responsiveness in rabbits.
Topics: Acetylcholine; Administration, Inhalation; Airway Resistance; Animals; Bronchi; Bronchoconstriction; Capsaicin; Disease Models, Animal; Lung Diseases; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Occupational Diseases; Rabbits; Receptors, Neurokinin-2; Substance P; Toluene 2,4-Diisocyanate; Trachea | 1996 |
Detection of alterations in the levels of neuropeptides and salivary gland responses in the non-obese diabetic mouse model for autoimmune sialoadenitis.
Topics: Animals; Autoimmune Diseases; Disease Models, Animal; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Neuropeptide Y; Neuropeptides; Salivary Glands; Sialadenitis; Substance P; Vasoactive Intestinal Peptide | 1997 |
Upregulation of neuropeptides and neuropeptide receptors in a murine model of immune inflammation in lung parenchyma.
Topics: Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Female; Immunohistochemistry; Inflammation Mediators; Leukocytes; Mice; Mice, Inbred C57BL; Pneumonia; Receptors, Neurokinin-1; Receptors, Vasoactive Intestinal Peptide; RNA, Messenger; Substance P; Vasoactive Intestinal Peptide | 1997 |
An experimental study of the neurogenic and the immunological contribution to "tennis elbow" in rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Injections, Intra-Arterial; Interleukin-1; Male; Neurokinin A; Neuropeptide Y; Neuropeptides; Perfusion; Rats; Rats, Sprague-Dawley; Substance P; Tennis Elbow | 1997 |
The novel anti-migraine agent rizatriptan inhibits neurogenic dural vasodilation and extravasation.
Topics: Analysis of Variance; Animals; Blood Proteins; Calcitonin Gene-Related Peptide; Disease Models, Animal; Dura Mater; Electric Stimulation; Injections, Intravenous; Lethal Dose 50; Male; Meningeal Arteries; Migraine Disorders; Neuromuscular Junction; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Substance P; Triazoles; Trigeminal Nuclei; Tryptamines; Vasodilation | 1997 |
Renal function of substance P in rats chronically exposed to hypoxia.
Topics: Altitude Sickness; Animals; Chronic Disease; Disease Models, Animal; Female; Glomerular Filtration Rate; Hypoxia; Infusions, Intravenous; Kallikreins; Kidney; Rats; Rats, Wistar; Sodium; Substance P | 1997 |
Hyperdynamic circulation of cirrhotic rats: role of substance P and its relationship to nitric oxide.
Topics: Analysis of Variance; Animals; Colorimetry; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hemodynamics; Liver Cirrhosis, Experimental; Male; Nitric Oxide; Portal System; Rats; Rats, Sprague-Dawley; Reference Values; Substance P | 1997 |
Plasma protein extravasation induced in the rat dura mater by stimulation of the parasympathetic sphenopalatine ganglion.
Topics: Acetylcholine; Afferent Pathways; Animals; Atropine; Axons; Blood Pressure; Blood Proteins; Calcitonin Gene-Related Peptide; Capsaicin; Carbachol; Disease Models, Animal; Dura Mater; Electric Stimulation; Exudates and Transudates; Ganglia, Parasympathetic; Inflammation; Injections, Intra-Arterial; Male; Migraine Disorders; Neurons, Afferent; Parasympathetic Fibers, Postganglionic; Parasympathomimetics; Permeability; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Serum Albumin, Bovine; Substance P | 1997 |
Effects of experimental Mycoplasma pulmonis infection on sensory neuropeptides and airway mucosa in the rat.
Topics: Animals; Blotting, Northern; Calcitonin Gene-Related Peptide; Chronic Disease; Culture Techniques; Disease Models, Animal; Immunohistochemistry; Male; Mucous Membrane; Mycoplasma Infections; Nasal Mucosa; Neuropeptides; Rats; Rats, Inbred Strains; Respiratory Tract Infections; Substance P; Trachea; Trigeminal Ganglion | 1997 |
Temporal changes in spinal cord expression of mRNA for substance P, dynorphin and enkephalin in a model of chronic pain.
Topics: Animals; Behavior, Animal; Chronic Disease; Disease Models, Animal; Dynorphins; Enkephalins; Gene Expression; Male; Neuropeptides; Pain; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spinal Cord; Substance P; Time Factors | 1997 |
Role of substance P in several models of bladder inflammation.
Topics: Animals; Biphenyl Compounds; Cystitis; Disease Models, Animal; Female; Immunohistochemistry; Lipopolysaccharides; Neurokinin-1 Receptor Antagonists; Poly I-C; Rats; Substance P; Urinary Bladder; Urination; Xylenes | 1997 |
Effects of capsaicin in temporomandibular joint arthritis in rats.
Topics: Animals; Arthritis; Calcitonin Gene-Related Peptide; Capsaicin; Chromatography, High Pressure Liquid; Denervation; Disease Models, Animal; Female; Mandibular Nerve; Neurons, Afferent; Neuropeptide Y; Neurotoxins; Nontuberculous Mycobacteria; Radioimmunoassay; Rats; Rats, Inbred Lew; Substance P; Sympathetic Nervous System; Temporomandibular Joint; Temporomandibular Joint Disorders; Trigeminal Ganglion | 1997 |
Hyperinnervation of the airways in transgenic mice overexpressing nerve growth factor.
Topics: Airway Resistance; Animals; Capsaicin; Catecholamines; Disease Models, Animal; Gene Expression; Lung; Mice; Mice, Transgenic; Nerve Growth Factors; Neurons, Afferent; Oxidopamine; Promoter Regions, Genetic; Proteins; Rats; RNA, Messenger; Substance P; Uteroglobin | 1998 |
Role of substance P in experimental allergic conjunctivitis in guinea pigs.
Topics: Animals; Capillary Permeability; Capsaicin; Conjunctiva; Conjunctivitis, Allergic; Dipeptides; Disease Models, Animal; Guinea Pigs; Histamine; Indoles; Male; Mast Cells; Ovalbumin; p-Methoxy-N-methylphenethylamine; Serine Proteinase Inhibitors; Substance P; Tears | 1997 |
Role of sensory innervation and mast cells in neurogenic plasma protein exudation into the airway lumen.
Topics: Analysis of Variance; Animals; Blood Proteins; Bronchoalveolar Lavage Fluid; Capillary Permeability; Capsaicin; Chromatography, High Pressure Liquid; Disease Models, Animal; Electric Stimulation; Exudates and Transudates; Histamine; Inflammation; Mast Cells; Neuropeptides; Probability; Rats; Rats, Sprague-Dawley; Reference Values; Substance P; Trachea; Vagus Nerve | 1997 |
Modulation of peripheral inflammation by locally administered hemorphin-7.
Topics: Animals; Blister; Calcitonin Gene-Related Peptide; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Hemoglobins; Hindlimb; Inflammation; Male; Naloxone; Narcotic Antagonists; Nerve Fibers; Opioid Peptides; Peptide Fragments; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Substance P; Vacuum; Wound Healing | 1998 |
The effect of epidural injection of betamethasone or bupivacaine in a rat model of lumbar radiculopathy.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Betamethasone; Bupivacaine; Calcitonin Gene-Related Peptide; Cell Count; Disease Models, Animal; Glucocorticoids; Immunohistochemistry; Injections, Epidural; Lumbar Vertebrae; Male; Motor Activity; Polyradiculopathy; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Substance P | 1998 |
Intraaccumbens injections of substance P, morphine and amphetamine: effects on conditioned place preference and behavioral activity.
Topics: Acute Disease; Amphetamine; Animals; Behavior, Animal; Conditioning, Psychological; Disease Models, Animal; Dopamine; Grooming; Locomotion; Male; Morphine; Morphine Dependence; Motivation; Narcotics; Nucleus Accumbens; Rats; Rats, Wistar; Reward; Spatial Behavior; Substance P; Sympathomimetics | 1998 |
Immunization and challenge with toluene diisocyanate decrease tachykinin and calcitonin gene-related peptide immunoreactivity in guinea pig central airways.
Topics: Animals; Bronchial Provocation Tests; Calcitonin Gene-Related Peptide; Cell Count; Disease Models, Animal; Eosinophils; Guinea Pigs; Immunization; Immunoglobulin G; Immunohistochemistry; Inflammation; Male; Nerve Fibers; Respiratory System; Substance P; Tachykinins; Toluene 2,4-Diisocyanate | 1998 |
An experimental model of tennis elbow in rats: a study of the contribution of the nervous system.
Topics: Animals; Calcitonin Gene-Related Peptide; Carrageenan; Disease Models, Animal; Freund's Adjuvant; Immunohistochemistry; Male; Nervous System; Neurokinin A; Neurons, Afferent; Neuropeptide Y; Neuropeptides; Rats; Rats, Sprague-Dawley; Substance P; Sympathetic Nervous System; Tennis Elbow | 1998 |
Neurokinin receptors in feline interstitial cystitis.
Topics: Animals; Cat Diseases; Cats; Cystitis, Interstitial; Disease Models, Animal; Iodine Radioisotopes; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Pain; Radiopharmaceuticals; Receptors, Neurokinin-1; Substance P; Tritium | 1998 |
Anti-hyperalgesic properties of the extract and of the main sesquiterpene polygodial isolated from the barks of Drymis winteri (Winteraceae).
Topics: Abdominal Pain; Acetic Acid; Animals; Bradykinin; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Hyperalgesia; Male; Mice; Motor Activity; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Sesquiterpenes; Substance P; Zymosan | 1998 |
Effect of substance P on the short-circuit current of rat nasal mucosal epithelium.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Disease Models, Animal; Electric Stimulation; Epithelium; Histamine H1 Antagonists; Histamine H2 Antagonists; Histamine Release; Male; Mast Cells; Nasal Mucosa; Pyrilamine; Ranitidine; Rats; Rats, Sprague-Dawley; Rhinitis, Allergic, Seasonal; Substance P | 1998 |
Induction of nitric oxide synthase by lipopolysaccharide inhalation enhances substance P-induced microvascular leakage in guinea-pigs.
Topics: Administration, Inhalation; Analysis of Variance; Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Capillary Leak Syndrome; Capillary Permeability; Disease Models, Animal; Evans Blue; Guinea Pigs; Lipopolysaccharides; Male; Nitric Oxide Synthase; Probability; Reference Values; Substance P | 1998 |
Oral anti-inflammatory action of NPC 18884, a novel bradykinin B2 receptor antagonist.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Bradykinin Receptor Antagonists; Carrageenan; Dipeptides; Disease Models, Animal; Drug Interactions; Female; Histamine; Male; Mice; Pleurisy; Receptor, Bradykinin B2; Substance P | 1998 |
Alterations of the intramural nervous distributions in a chick intestinal atresia model.
Topics: Actins; Animals; Chick Embryo; Disease Models, Animal; Enteric Nervous System; Humans; Immunohistochemistry; Intestinal Atresia; Models, Neurological; NADPH Dehydrogenase; Nerve Tissue Proteins; Staining and Labeling; Substance P; Thiolester Hydrolases; Ubiquitin Thiolesterase; Vasoactive Intestinal Peptide | 1999 |
Dilatory responses to acetylcholine, calcitonin gene-related peptide and substance P in the congestive heart failure rat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Dose-Response Relationship, Drug; Heart Failure; In Vitro Techniques; Male; Myocardial Infarction; Myocardial Ischemia; Potassium; Rats; Rats, Sprague-Dawley; Substance P; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 1999 |
The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia.
Topics: Amitriptyline; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antidepressive Agents, Tricyclic; Clonazepam; Dinoprostone; Disease Models, Animal; Hyperalgesia; Indomethacin; Male; Neuralgia; Pain; Pain Threshold; Peripheral Nerve Injuries; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Saccharomyces cerevisiae; Sciatic Nerve; Seminal Vesicles; Sheep; Substance P | 1999 |
Inhibitory effects of tachykinin receptor antagonists on thermally induced inflammatory reactions in a rat model.
Topics: Animals; Burns; Disease Models, Animal; Edema; Follow-Up Studies; Inflammation; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Skin Diseases; Substance P | 1999 |
Substance P binding in gastrointestinal tract of nondiabetic BB rat and changes in diabetic BB rat over time.
Topics: Animals; Autoradiography; Diabetes Mellitus, Type 1; Digestive System; Disease Models, Animal; Gastrointestinal Motility; Male; Rats; Rats, Inbred BB; Receptors, Neurokinin-1; Substance P; Time Factors | 1999 |
Rat model of Achilles tendon disorder. A pilot study.
Topics: Achilles Tendon; Animals; Biomechanical Phenomena; Calcitonin Gene-Related Peptide; Chronic Disease; Collagen; Cumulative Trauma Disorders; Disease Models, Animal; Gait; Hindlimb; Hip Joint; Male; Peripheral Nerves; Physical Conditioning, Animal; Pilot Projects; Rats; Rats, Sprague-Dawley; Substance P; Torque | 1999 |
Prenatal methylazoxymethanol acetate alters behavior and brain NGF levels in young rats: a possible correlation with the development of schizophrenia-like deficits.
Topics: Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Brain; Disease Models, Animal; Exploratory Behavior; Female; Methylazoxymethanol Acetate; Nerve Growth Factors; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Schizophrenia; Social Behavior; Substance P | 1999 |
Serotonin-2 receptor stimulation normalizes striatal preprotachykinin messenger RNA in an animal model of Parkinson's disease.
Topics: Amphetamines; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Drug Administration Schedule; Gene Expression Regulation; In Situ Hybridization; Male; Neural Pathways; Oxidopamine; Parkinson Disease, Secondary; Protein Precursors; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; RNA, Messenger; Serotonin; Serotonin Receptor Agonists; Substance P; Substantia Nigra; Tachykinins | 1999 |
Early effects of intrastriatal injections of quinolinic acid on microtubule-associated protein-2 and neuropeptides in rat basal ganglia.
Topics: Animals; Basal Ganglia; Corpus Striatum; Cytoskeleton; Disease Models, Animal; DNA Damage; Efferent Pathways; Enkephalins; Excitatory Amino Acid Agonists; Globus Pallidus; Huntington Disease; Injections; Male; Mice; Mice, Neurologic Mutants; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neurons; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Substance P | 1999 |
Chemical and anatomical changes in the striatum and substantia nigra following quinolinic acid lesions in the striatum of the rat: a detailed time course of the cellular and GABA(A) receptor changes.
Topics: Animals; Autoradiography; Corpus Striatum; Disease Models, Animal; Huntington Disease; Immunohistochemistry; Male; Neuroglia; Nissl Bodies; Quinolinic Acid; Rats; Rats, Wistar; Receptors, GABA-A; Substance P; Substantia Nigra; Time Factors | 1999 |
Antigen inhalation unmasks NK-2 tachykinin receptor-mediated responses in vagal afferents.
Topics: Animals; Antigens; Benzamides; Disease Models, Animal; Guinea Pigs; Male; Membrane Potentials; Microscopy, Electron, Scanning; Neurokinin-1 Receptor Antagonists; Ovalbumin; Patch-Clamp Techniques; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Trachea; Tracheitis; Vagotomy; Vagus Nerve | 2000 |
Decrease in striatal enkephalin mRNA in mouse models of Huntington's disease.
Topics: Animals; Biomarkers; Calbindins; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; DNA Damage; Enkephalins; Female; Glutamate Decarboxylase; Homozygote; Huntingtin Protein; Huntington Disease; Isoenzymes; Male; Mice; Mice, Knockout; Mice, Neurologic Mutants; Motor Activity; Nerve Tissue Proteins; Neurons; Nuclear Proteins; RNA, Messenger; S100 Calcium Binding Protein G; Substance P; Trinucleotide Repeats | 2000 |
Inhibitory effects of methanol extracts of herbal medicines on substance P-induced itch-scratch response.
Topics: Animals; Antipruritics; Disease Models, Animal; Male; Methanol; Mice; Mice, Inbred ICR; Phytotherapy; Plants, Medicinal; Pruritus; Substance P | 2000 |
Cyclosporine A-induced hypertension involves synapsin in renal sensory nerve endings.
Topics: Afferent Pathways; Animals; Blood Pressure; Capsaicin; Cyclosporine; Disease Models, Animal; Female; Hypertension; Immunohistochemistry; Immunophilins; Kidney; Ligands; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Endings; Neurons, Afferent; rab3A GTP-Binding Protein; Substance P; Sympathetic Nervous System; Synapsins; Synaptic Vesicles | 2000 |
Self-sustaining status epilepticus: a condition maintained by potentiation of glutamate receptors and by plastic changes in substance P and other peptide neuromodulators.
Topics: Age Factors; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electroencephalography; Electroshock; Hippocampus; Neuronal Plasticity; Neurotransmitter Agents; Perforant Pathway; Phenytoin; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Status Epilepticus; Substance P | 2000 |
L-DOPA produces strong induction of c-fos messenger RNA in dopamine-denervated cortical and striatal areas of the common marmoset.
Topics: Animals; Benzazepines; Blotting, Western; Callithrix; Cerebral Cortex; Corpus Striatum; Denervation; Disease Models, Animal; Dopamine; Dopamine Agents; Dopamine Antagonists; Enkephalins; Gene Expression; Genes, Immediate-Early; Levodopa; Nerve Degeneration; Oxidopamine; Parkinson Disease; Protein Precursors; Proto-Oncogene Proteins c-fos; Raclopride; Radioligand Assay; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Substance P; Substantia Nigra; Sympatholytics; Tritium | 2000 |
Transient global ischemia in rats yields striatal projection neuron and interneuron loss resembling that in Huntington's disease.
Topics: Animals; Cell Survival; Choline O-Acetyltransferase; Corpus Striatum; Disease Models, Animal; Enkephalins; Huntington Disease; Image Processing, Computer-Assisted; Interneurons; Ischemic Attack, Transient; Male; NADPH Dehydrogenase; Nerve Fibers; Neural Pathways; Rats; Rats, Sprague-Dawley; Rats, Wistar; Somatostatin; Substance P | 2000 |
Response of the cricothyroid and thyroarytenoid muscles to stereotactic injection of substance P into the region of the nucleus tractus solitarius in developing dogs.
Topics: Age Factors; Animals; Disease Models, Animal; Dogs; Electromyography; Humans; Infant, Newborn; Laryngeal Muscles; Laryngismus; Motor Activity; Muscle Development; Solitary Nucleus; Stereotaxic Techniques; Substance P; Sudden Infant Death | 2000 |
A transplantable human carcinoid as model for somatostatin receptor-mediated and amine transporter-mediated radionuclide uptake.
Topics: 3-Iodobenzylguanidine; 5-Hydroxytryptophan; Animals; Biogenic Amines; Calcium; Carcinoid Tumor; Carrier Proteins; Chromogranin A; Chromogranins; Chromosome Painting; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxyindoleacetic Acid; Ileal Neoplasms; Immunohistochemistry; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Nude; Middle Aged; Neuropeptides; Octreotide; Radioisotopes; Receptors, Somatostatin; RNA, Messenger; Serotonin; Substance P; Transplantation, Heterologous; Tumor Cells, Cultured; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2001 |
Dorsal horn lesion resulting from spinal root avulsion leads to the accumulation of stress-responsive proteins.
Topics: Animals; Anterior Horn Cells; Astrocytes; Axotomy; Disease Models, Animal; Female; Glial Fibrillary Acidic Protein; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Immunohistochemistry; Lumbosacral Region; Microglia; Mitogen-Activated Protein Kinases; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Peripheral Nerves; Phosphorylation; Posterior Horn Cells; Radiculopathy; Rats; Rats, Wistar; Substance P; Substantia Gelatinosa; Synapses | 2001 |
Calcitonin gene-related peptide, substance P and protein gene product 9.5 immunoreactive axonal fibers in the rat footpad skin following partial sciatic nerve injuries.
Topics: Animals; Axons; Calcitonin Gene-Related Peptide; Disease Models, Animal; Foot; Immunohistochemistry; Male; Microscopy, Electron; Nerve Crush; Nerve Regeneration; Neuronal Plasticity; Nociceptors; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sensory Receptor Cells; Skin; Substance P; Thiolester Hydrolases; Ubiquitin Thiolesterase | 2000 |
Involvement of substance P and central opioid receptors in morphine modulation of the CHS response.
Topics: Androstanes; Animals; Benzimidazoles; Dermatitis, Contact; Dinitrofluorobenzene; Disease Models, Animal; Drug Administration Routes; Male; Morphine; Naltrexone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Inbred Lew; Receptors, Opioid; Specific Pathogen-Free Organisms; Substance P | 2001 |
Differential roles of spinal neurokinin 1/2 receptors in development of persistent spontaneous nociception and hyperalgesia induced by subcutaneous bee venom injection in the conscious rat.
Topics: Analgesics; Animals; Bee Venoms; Consciousness; Disease Models, Animal; Hot Temperature; Hyperalgesia; Injections, Subcutaneous; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain Threshold; Physical Stimulation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Spinal Cord; Substance P | 2001 |
Nitric oxide deficiency contributes to impairment of airway relaxation in cystic fibrosis mice.
Topics: Animals; Arginine; Bronchoconstriction; Cystic Fibrosis; Dinoprostone; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Female; In Vitro Techniques; Male; Mice; Mice, Inbred CFTR; Muscle Relaxation; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Substance P; Trachea | 2001 |
Neuropeptide expression in the ferret trigeminal ganglion following ligation of the inferior alveolar nerve.
Topics: Analysis of Variance; Animals; Axons; Calcitonin Gene-Related Peptide; Cell Count; Disease Models, Animal; Enkephalins; Female; Ferrets; Fluorescent Dyes; Follow-Up Studies; Galanin; Gene Expression; Horseradish Peroxidase; Immunohistochemistry; Lectins; Ligation; Mandibular Nerve; Neural Pathways; Neuropeptide Y; Neuropeptides; Sensation Disorders; Statistics as Topic; Stilbamidines; Substance P; Trigeminal Ganglion; Trigeminal Nerve Injuries; Vasoactive Intestinal Peptide | 2001 |
The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Ibuprofen; Injections, Intraperitoneal; Injections, Spinal; Isoenzymes; Male; Membrane Proteins; N-Methylaspartate; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 2001 |
Antinociceptive effect following dietary-induced thiamine deficiency in mice: involvement of substance P and somatostatin.
Topics: Analgesia; Animals; Avoidance Learning; Behavior, Animal; Diet; Disease Models, Animal; Hindlimb; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Pain Measurement; Pain Threshold; Somatostatin; Substance P; Thiamine; Thiamine Deficiency | 2001 |
Leukaemia inhibitory factor abrogates Paclitaxel-induced axonal atrophy in the Wistar rat.
Topics: Animals; Antineoplastic Agents, Phytogenic; Axons; Calcitonin Gene-Related Peptide; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Ganglia, Spinal; Growth Inhibitors; Immunohistochemistry; Interleukin-6; Leukemia Inhibitory Factor; Lymphokines; Nerve Degeneration; Neural Conduction; Neurons, Afferent; Paclitaxel; Peripheral Nervous System Diseases; Rats; Rats, Wistar; Substance P | 2001 |
Relationship between pancreatitis and lung diseases.
Topics: Acute Disease; Animals; Complement C5a; Disease Models, Animal; Female; Humans; Intercellular Adhesion Molecule-1; Lung Diseases; Mice; Mice, Knockout; Neutrophils; Pancreatitis; Platelet Activating Factor; Rats; Receptors, CCR1; Receptors, Chemokine; Substance P | 2001 |
The influence of experimentally induced osteoarthrosis on articular nerve fibers of the sheep temporomandibular joint.
Topics: Analysis of Variance; Animals; Autonomic Nervous System; Calcitonin Gene-Related Peptide; Cicatrix; Cysts; Disease Models, Animal; Fibrosis; Image Processing, Computer-Assisted; Immunohistochemistry; Joint Capsule; Male; Mandibular Condyle; Nerve Fibers; Nerve Tissue Proteins; Neurons, Afferent; Neuropeptide Y; Osteoarthritis; Sheep; Statistics, Nonparametric; Substance P; Synovial Membrane; Temporomandibular Joint; Temporomandibular Joint Disc; Temporomandibular Joint Disorders; Thiolester Hydrolases; Tyrosine 3-Monooxygenase; Ubiquitin Thiolesterase; Vasoactive Intestinal Peptide | 2001 |
Antinociceptive profiles of aspirin and acetaminophen in formalin, substance P and glutamate pain models.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Aspirin; Behavior, Animal; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Foot; Glutamic Acid; Male; Mice; Mice, Inbred ICR; Nociceptors; Pain; Pain Measurement; Receptors, Glutamate; Receptors, Neurokinin-1; Spinal Cord; Substance P; Synaptic Transmission | 2001 |
The role of substance P release in the lung with esophageal acid.
Topics: Animals; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Esophagus; Extravasation of Diagnostic and Therapeutic Materials; Glycopeptides; Guinea Pigs; Hydrochloric Acid; Indoles; Lung; Reference Values; Sensitivity and Specificity; Substance P; Vagotomy | 2001 |
ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity.
Topics: Animals; Butadienes; Disease Models, Animal; Enkephalins; Enzyme Activation; Enzyme Inhibitors; Freund's Adjuvant; Hindlimb; Hyperalgesia; Inflammation; Injections, Spinal; Male; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Pain; Posterior Horn Cells; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spinal Cord; Substance P; Up-Regulation | 2002 |
LPS-sensory peptide communication in experimental cystitis.
Topics: Administration, Intravesical; Animals; Contrast Media; Cystitis; Disease Models, Animal; Drug Synergism; Female; Fluorescein; Histamine; Interferon-gamma; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Neurons, Afferent; Neutrophils; Substance P; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Urinary Bladder; Urothelium | 2002 |
No influence of low-energy extracorporeal shock wave therapy (ESWT) on spinal nociceptive systems.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Female; Immunohistochemistry; Lithotripsy; Lumbar Vertebrae; Male; Pain; Pain Management; Rats; Rats, Wistar; Reference Values; Sensitivity and Specificity; Spinal Cord; Substance P | 2002 |
Antipruritic activity of the kappa-opioid receptor agonist, TRK-820.
Topics: Animals; Antipruritics; Chlorpheniramine; Disease Models, Animal; Histamine; Histamine H1 Antagonists; Ketotifen; Male; Mice; Mice, Inbred ICR; Morphinans; Motor Activity; Naltrexone; Pruritus; Receptors, Opioid, kappa; Spiro Compounds; Substance P | 2002 |
Attenuation of hyperalgesia in a rat model of neuropathic pain after intrathecal pre- or post-treatment with a neurokinin-1 antagonist.
Topics: Animals; Cold Temperature; Disease Models, Animal; Hyperalgesia; Injections, Spinal; Male; Neurokinin-1 Receptor Antagonists; Nociceptors; Physical Stimulation; Rats; Rats, Long-Evans; Sciatica; Substance P; Tryptophan | 2002 |
Evidence for a neuropathic contribution to the development of spontaneous knee osteoarthrosis in a mouse model.
Topics: Aging; Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Immunohistochemistry; Knee Joint; Male; Mechanoreceptors; Mice; Mice, Inbred C57BL; Neuropeptides; Osteoarthritis, Knee; Risk Assessment; Risk Factors; Sensitivity and Specificity; Severity of Illness Index; Substance P | 2002 |
Temporal decrease in renal sensory responses in rats after chronic ligation of the bile duct.
Topics: Animals; Cholestasis; Chronic Disease; Disease Models, Animal; Gene Expression; Kidney; Ligation; Liver Cirrhosis, Biliary; Male; Neurons, Afferent; Physical Stimulation; Rats; Rats, Wistar; Receptors, Neurokinin-1; Reflex; RNA, Messenger; Sodium Chloride; Substance P; Urinary Catheterization; Urine | 2002 |
Noradrenergic and peptidergic innervation of secondary lymphoid organs: role in experimental rheumatoid arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Denervation; Disease Models, Animal; In Vitro Techniques; Lymphoid Tissue; Male; Nerve Fibers; Norepinephrine; Rats; Rats, Inbred Lew; Substance P | 1992 |
Neonatal capsaicin treatment prevents the development of the thermal hyperalgesia produced in a model of neuropathic pain in the rat.
Topics: Animals; Animals, Newborn; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Hot Temperature; Male; Nervous System Diseases; Pain; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 1992 |
Mechanisms contributing to ozone-induced bronchial hyperreactivity in guinea-pigs.
Topics: Adenine Nucleotides; Animals; Ascorbic Acid; Atropine; Bronchial Hyperreactivity; Bronchoconstriction; Disease Models, Animal; Fentanyl; Glutathione; Guinea Pigs; Histamine; Indomethacin; Lipoxygenase Inhibitors; Male; Neprilysin; Oligopeptides; Oxidation-Reduction; Ozone; Pyrilamine; Substance P; Vagus Nerve | 1992 |
Effect of interleukin-1 receptor antagonist on antigen-induced pulmonary responses in guinea pigs.
Topics: Aerosols; Anaphylaxis; Animals; Antigens; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Guinea Pigs; Humans; Leukocyte Count; Lymphocytes; Male; Neutrophils; Pneumonia; Receptors, Immunologic; Receptors, Interleukin-1; Sensitivity and Specificity; Substance P; Time Factors | 1992 |
Innervation of bone from healthy and arthritic rats by substance P and calcitonin gene related peptide containing sensory fibers.
Topics: Animals; Arthritis, Experimental; Bone and Bones; Bone Marrow; Calcitonin Gene-Related Peptide; Disease Models, Animal; Growth Plate; Immunohistochemistry; Male; Neurons, Afferent; Periosteum; Rats; Stress, Mechanical; Substance P | 1992 |
Time-related decrease of substance P and CGRP in central and peripheral projections of sensory neurones in Mycobacterium leprae infected nude mice: a model for lepromatous leprosy in man.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Leprosy, Lepromatous; Mice; Mice, Nude; Motor Neurons; Neurons, Afferent; Skin; Spinal Cord; Substance P; Time Factors | 1990 |
Recombinant enkephalinase effectively inhibits substance P-induced miosis in the rabbit eye cup model.
Topics: Animals; Atropine; Disease Models, Animal; Female; Humans; Iris; Miosis; Neprilysin; Rabbits; Recombinant Proteins; Substance P; Thiorphan | 1990 |
Measurement of neuropeptides in the brain and spinal cord of Wobbler mouse: a model for motoneuron disease.
Topics: Aging; Animals; Brain; Brain Chemistry; Disease Models, Animal; Enkephalin, Leucine; Enkephalin, Methionine; Mice; Mice, Neurologic Mutants; Motor Neurons; Neuromuscular Diseases; Neuropeptides; Somatostatin; Spinal Cord; Substance P; Thyrotropin-Releasing Hormone | 1990 |
Effect of bladder outflow obstruction on the innervation of the rabbit urinary bladder.
Topics: Animals; Denervation; Disease Models, Animal; Isoproterenol; Male; Muscle, Smooth; Parasympathetic Nervous System; Rabbits; Substance P; Urinary Bladder; Urinary Bladder Neck Obstruction; Urodynamics | 1990 |
Baseline and apomorphine-induced extracellular levels of nigral substance P are increased in an animal model of Parkinson's disease.
Topics: Animals; Apomorphine; Dialysis; Disease Models, Animal; Dopamine; Ganglia, Sympathetic; Hydroxydopamines; Neurons; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra | 1990 |
Nerves in inflammatory synovium: immunohistochemical observations on the adjuvant arthritis rat model.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Calcitonin Gene-Related Peptide; Disease Models, Animal; Humans; Immune Sera; Immunohistochemistry; Neuropeptides; Rats; Substance P; Synovial Membrane; Synovitis; Ubiquitin Thiolesterase | 1990 |
Chronic quinolinic acid lesions in rats closely resemble Huntington's disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Atrophy; Biogenic Amines; Cerebral Cortex; Choline O-Acetyltransferase; Corpus Striatum; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamates; Huntington Disease; Ibotenic Acid; Kainic Acid; Male; Mesencephalon; NADPH Dehydrogenase; Neurons; Neuropeptide Y; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Reference Values; Somatostatin; Substance P | 1991 |
Neurogenic component of different models of acute inflammation in the rat knee joint.
Topics: Animals; Capsaicin; Carrageenan; Disease Models, Animal; Formaldehyde; Hindlimb; Inflammation; Joints; Male; p-Methoxy-N-methylphenethylamine; Rats; Rats, Inbred Strains; Substance P; Uric Acid | 1991 |
Neuropeptide changes in a primate model (Cebus apella) for tardive dyskinesia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Brain Chemistry; Cebus; Corpus Striatum; Disease Models, Animal; Dynorphins; Dyskinesia, Drug-Induced; Female; Globus Pallidus; Glutamate Decarboxylase; Homovanillic Acid; Male; Neuropeptides; Substance P; Substantia Nigra | 1990 |
Release of substance P from peripheral nerve terminals following electrical stimulation of the sciatic nerve.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Inflammation; Male; Nerve Endings; Peripheral Nerves; Rats; Rats, Inbred Strains; Substance P | 1985 |
Neuropeptides and dopamine in the marmoset. Effect of treatment with 1-methyl-4-phenyl-1, 2, 3, 6 tetrahydropyridine (MPTP): an animal model for Parkinson's disease?
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain Chemistry; Callitrichinae; Cholecystokinin; Disease Models, Animal; Dopamine; Female; Kidney; Male; Neurotensin; Parkinson Disease, Secondary; Pyridines; Substance P; Vasoactive Intestinal Peptide | 1986 |
Substance P neurons sprout in the cervical spinal cord of the wobbler mouse: a model for motoneuron disease.
Topics: Acetylcholinesterase; Animals; Disease Models, Animal; Female; Histocytochemistry; Immunoenzyme Techniques; Male; Mice; Mice, Neurologic Mutants; Motor Activity; Motor Neurons; Nerve Regeneration; Neuromuscular Diseases; Neuronal Plasticity; Spinal Cord; Substance P | 1986 |
Changes of neuropeptide immunoreactivity in cerebrovascular nerve fibers after experimentally produced SAH. Immunohistochemical study in the dog.
Topics: Animals; Basilar Artery; Cerebral Arteries; Disease Models, Animal; Dogs; Female; Immunoenzyme Techniques; Male; Nerve Fibers; Neuropeptide Y; Subarachnoid Hemorrhage; Substance P; Vasoactive Intestinal Peptide | 1987 |
Report of the 1985 ISSLS Traveling Fellowship. Mechanisms of spinal pain. The dorsal root ganglion and its role as a mediator of low-back pain.
Topics: Animals; Back Pain; Disease Models, Animal; Female; Ganglia, Spinal; Rabbits; Substance P; Vibration | 1986 |
Systemic approaches to modifying quinolinic acid striatal lesions in rats.
Topics: 2-Amino-5-phosphonovalerate; Allopurinol; Amino Acids; Animals; Antioxidants; Baclofen; Corpus Striatum; Dibenzocycloheptenes; Disease Models, Animal; Dizocilpine Maleate; Huntington Disease; Ketamine; Male; Neuropeptide Y; Nimodipine; Peptides; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Substance P; Taurine; Valine | 1988 |
Role of the mediators in pulmonary hyperreactivity: the cocktail interaction hypothesis.
Topics: Acetylcholine; Animals; Bradykinin; Disease Models, Animal; Drug Synergism; Guinea Pigs; Male; Prostaglandins D; Respiratory Hypersensitivity; Substance P | 1989 |
The effects of capsaicin treatment on self-administration of amphetamine vapor in rats.
Topics: Administration, Inhalation; Amphetamine; Animals; Brain; Capsaicin; Cocaine; Disease Models, Animal; Rats; Rats, Inbred Strains; Self Administration; Substance P | 1989 |
[Effect of glycine on chronic morphinism].
Topics: Aggression; Animals; Disease Models, Animal; Drug Synergism; Glycine; Humans; Mice; Morphine Dependence; Nalorphine; Substance P; Substance Withdrawal Syndrome | 1974 |