Page last updated: 2024-08-23

substance p and Cough

substance p has been researched along with Cough in 64 studies

Research

Studies (64)

TimeframeStudies, this research(%)All Research%
pre-19905 (7.81)18.7374
1990's20 (31.25)18.2507
2000's22 (34.38)29.6817
2010's13 (20.31)24.3611
2020's4 (6.25)2.80

Authors

AuthorsStudies
Chen, R; Chen, Z; Dong, J; Huang, J; Ji, X; Xu, Y; Yan, W; Zhan, C; Zheng, Z; Zhi, H; Zhong, M1
Jia, W; Jia, Y; Li, R; Qu, Y; Wan, C; Wang, W; Zhang, W; Zhang, Z; Zhou, Q1
Guan, M; Wang, Y; Ying, S1
Abo, M; Fujigasaki, H; Hara, T; Hashimoto, G; Ide, T; Niimi, M; Yamada, N1
Liu, L; Sun, T; Wang, L; Zhang, L1
Cui, F; Mei, B; Shen, M; Wang, W; Wen, Z; Wu, C1
Asano, T; Fukumitsu, K; Hijikata, H; Kamiya, T; Kanemitsu, Y; Kubota, E; Niimi, A; Suzuki, M; Takeda, N; Takemura, M; Ueda, T; Yamaba, Y1
Li, PB; Luo, YL; Nie, YC; Su, WW; Wang, S; Zhang, CC; Zhang, KJ; Zheng, YF1
Feixia, L; Jia, Z1
Cao, X; Chai, S; Chen, Z; Dong, R; Ji, Z; Lai, K; Lv, H; Yue, J; Zhan, J; Zhang, H1
Bonham, AC; Bric, J; Chen, CY; Joad, JP1
Dicpinigaitis, PV; Sitkauskiene, B1
Abo, M; Fujimura, M; Furusho, S; Katayama, N; Ohkura, N; Tokuda, A1
Gu, Q; Lee, LY; Lin, YS1
Canning, BJ; Mori, N1
Liu, B; Lü, H; Qiu, Z; Xu, S; Yu, L; Zhao, T1
Aoyama, N; Chin, K; Ito, I; Jinnai, M; Matsumoto, H; Matsuoka, H; Mishima, M; Nakaji, H; Niimi, A; Oguma, T; Otsuka, K; Sasaki, K; Takeda, T; Yamaguchi, M1
Kita, H; Lim, KG; Moore, E; Patel, A; Rank, MA1
Ito, N; Miura, M; Sano, M; Sasaki, M; Shioya, T; Watanabe, A1
Davies, C; Harrison, NK; Hilldrup, S; Hope-Gill, BD; Newton, RP1
Arai, H; Ebihara, S; Kanda, A; Nakajoh, M; Saito, H; Sasaki, H; Takahashi, H1
Cho, YS; Lee, CK; Moon, HB; Park, SY; Yoo, B1
Bonham, AC; Bric, JM; Chen, CY; Evans, SJ; Joad, JP; Munch, PA; Pinkerton, KE1
Duffy, RA1
Asada, M; Ebihara, S; Ebihara, T; Okazaki, T; Sasaki, H; Takahashi, H; Watando, A1
Harrison, NK1
Bonham, AC; Joad, JP; Sekizawa, SI1
Advenier, C; Calò, G; D'Agostino, B; De Nardo, M; Gallelli, L; Guerrini, R; Marrocco, G; Rossi, F1
Amine, SA; El-Hashim, AZ1
Canning, BJ; Mazzone, SB; Mori, N1
Bongianni, F; Fontana, GA; Mutolo, D; Pantaleo, T1
Morimoto, K; Mukaiyama, O; Nosaka, E; Takahashi, S; Tsuchida, H; Yamashita, M1
Haraguchi, R; Iwanaga, T; Kubo, H; Muraki, M; Tohda, Y1
Aikawa, T; Sasaki, H; Sekizawa, K; Ujiie, Y1
Ebihara, T; Sasaki, H; Sekizawa, K1
Ansari, KU1
Fuchikami, J; Isohama, Y; Kai, H; Miyata, T; Takahama, K1
Abe, T; Ando, T; Fukuda, N; Ichimura, T; Kanno, N; Yanaihara, N; Yoshihara, S1
Fuller, RW; Krausz, T; Moradoghli-Haftvani, A; O'Connell, F; Polak, JM; Price, D; Pride, NB; Springall, DR1
Ebihara, T; Nakazawa, H; Ohrui, T; Sasaki, H; Sekizawa, K1
Ebihara, A; Fujimura, A; Shiga, T; Sunaga, K1
Bee, D; Crambes, O; Howard, P; Laude, EA1
Cross, LJ; Ennis, M; Heaney, LG1
Chadwick, IG; Jackson, PR; Kraskiewicz, M; Ramsay, LE; Yeo, WW1
Hirayama, Y; Ichinose, M; Kageyama, N; Miura, M; Shirato, K; Tomaki, M; Yamauchi, H1
Ishibashi-Ueda, H; Kawaguchi, AT; Kawashima, Y; Shirai, M; Yamano, M; Yamatodani, A1
Arai, T; Fujiwara, H; Kashiki, Y; Takaya, T; Toshima, S; Yasuda, Y; Yoshimi, N1
Minc, P; Szmidt, M1
Ennis, M; Forsythe, P; Heaney, LG; MacMahon, J; McGarvey, LP1
Advenier, C; Beerens, D; Gustin, P; Halloy, D; Moreaux, B; Nemmar, A; Vincke, G1
Beerens, D; Gustin, P; Moreaux, B; Nemmar, A1
Furuya, K; Kawakami, Y; Takahashi, T; Yamaguchi, E1
Echizen, H; Fukatsu, T; Hashiguchi, M; Itoh, T; Kariya, S; Nishimura, E; Odanaka, J; Ohtani, M; Okumura, H; Rikihisa, T; Takahashi, T; Uchino, K; Watanabe, K1
Barone, FC; Bush, B; Foley, JJ; Giardina, GA; Griswold, DE; Grugni, M; Hay, DW; Kilian, D; Kotzer, CJ; Legos, JJ; Lundberg, D; Luttmann, MA; Martin, LD; Potts, W; Raveglia, LF; Sandhu, P; Sarau, HM; Schmidt, DB; Underwood, DC1
Baas, AA; Evers, NA; van der Meer, C1
Sasaki, H; Sekizawa, K1
Katsumata, U; Nakazawa, H; Sasaki, H; Sekizawa, K; Takasugi, R; Ujie, Y1
Martinez, EJ; Seleznick, MJ1
Katsumata, U; Sasaki, H; Sekizawa, K; Takishima, T; Ujiie, Y1
Andersson, KE; Andersson, SI; Ekman, R; Thysell, H1
Borson, DB; Graf, PD; Kohrogi, H; Nadel, JA; Sekizawa, K1
Sekizawa, K1
Borson, DB; Bridenbaugh, R; Gorman, C; Kohrogi, H; Malfroy, B; Nadel, JA; Patton, JS1
Inoue, H; Katsumata, U; Sasaki, H; Sekizawa, K; Takishima, T1

Reviews

9 review(s) available for substance p and Cough

ArticleYear
Central mechanisms I: plasticity of central pathways.
    Handbook of experimental pharmacology, 2009, Issue:187

    Topics: Animals; Central Nervous System; Cough; Humans; Neural Pathways; Neuronal Plasticity; Reflex; Substance P

2009
Effect of smoking on cough reflex sensitivity in humans.
    Lung, 2010, Volume: 188 Suppl 1

    Topics: Action Potentials; Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Cough; Guinea Pigs; Humans; Lung; Models, Animal; Nerve Fibers, Unmyelinated; Nicotine; Nicotinic Agonists; Pulmonary Disease, Chronic Obstructive; Receptors, Nicotinic; Reflex; Smoking; Substance P

2010
Effect of smoking on cough reflex sensitivity: basic and preclinical studies.
    Lung, 2010, Volume: 188 Suppl 1

    Topics: Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cough; Guinea Pigs; Humans; Models, Animal; Nerve Fibers, Unmyelinated; Nicotine; Nicotinic Agonists; Receptors, Nicotinic; Reflex; Sensory System Agents; Smoking; Substance P

2010
Potential therapeutic targets for neurokinin-1 receptor antagonists.
    Expert opinion on emerging drugs, 2004, Volume: 9, Issue:1

    Topics: Analgesics; Anti-Anxiety Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Antiemetics; Antineoplastic Agents; Antitussive Agents; Anxiety; Asthma; Clinical Trials as Topic; Cough; Cystitis; Depression; Drug Design; Humans; Inflammation; Irritable Bowel Syndrome; Neoplasms; Neurokinin-1 Receptor Antagonists; Pain; Substance P; Vomiting

2004
Idiopathic pulmonary fibrosis: a nervous cough?
    Pulmonary pharmacology & therapeutics, 2004, Volume: 17, Issue:6

    Topics: Adrenal Cortex Hormones; Capsaicin; Cough; Humans; Nerve Growth Factors; Pulmonary Fibrosis; Substance P

2004
Plasticity of central mechanisms for cough.
    Pulmonary pharmacology & therapeutics, 2004, Volume: 17, Issue:6

    Topics: Animals; Central Nervous System; Cough; Guinea Pigs; Humans; Models, Animal; Neuronal Plasticity; Reflex; Solitary Nucleus; Substance P

2004
ACE inhibitor induced cough.
    The Journal of the Association of Physicians of India, 1994, Volume: 42, Issue:9

    Topics: Angiotensin-Converting Enzyme Inhibitors; Bradykinin; Cough; Humans; Prostaglandins; Substance P

1994
[Cough, bronchoconstriction and bronchial hyperreactivity in relation to treatment with angiotensin-converting enzyme].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 1999, Volume: 6, Issue:35

    Topics: Angiotensin-Converting Enzyme Inhibitors; Bradykinin; Bronchial Hyperreactivity; Bronchial Spasm; Cough; Histamine; Humans; Prostaglandins; Substance P

1999
Respiratory tract side effects of angiotensin converting enzyme inhibitors: current knowledge.
    Southern medical journal, 1991, Volume: 84, Issue:11

    Topics: Angiotensin-Converting Enzyme Inhibitors; Bradykinin; Cough; Humans; Nasal Obstruction; Receptors, Bradykinin; Receptors, Neurotransmitter; Substance P

1991

Trials

5 trial(s) available for substance p and Cough

ArticleYear
Daily oral care and cough reflex sensitivity in elderly nursing home patients.
    Chest, 2004, Volume: 126, Issue:4

    Topics: Activities of Daily Living; Aged; Aged, 80 and over; Cough; Dental Care for Aged; Female; Humans; Male; Nursing Homes; Oral Hygiene; Pneumonia, Aspiration; Reflex; Substance P

2004
Chronopharmacology of enalapril in hypertensive patients.
    European journal of clinical pharmacology, 1995, Volume: 48, Issue:6

    Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Bradykinin; Cough; Dinoprostone; Enalapril; Enalaprilat; Female; Half-Life; Humans; Hypertension; Male; Middle Aged; Substance P

1995
Resolution of ACE inhibitor cough: changes in subjective cough and responses to inhaled capsaicin, intradermal bradykinin and substance-P.
    British journal of clinical pharmacology, 1995, Volume: 40, Issue:5

    Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Bradykinin; Capsaicin; Cough; Enalapril; Female; Humans; Hypertension; Male; Middle Aged; Substance P

1995
The ACE gene polymorphism and cough threshold for capsaicin after cilazapril usage.
    Respiratory medicine, 2001, Volume: 95, Issue:2

    Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Bradykinin; Bronchial Provocation Tests; Capsaicin; Cilazapril; Cough; Cross-Over Studies; Double-Blind Method; Female; Genetic Predisposition to Disease; Genotype; Humans; Peptidyl-Dipeptidase A; Polymorphism, Genetic; Skin Tests; Substance P

2001
Bradykinin-induced cough reflex markedly increases in patients with cough associated with captopril and enalapril.
    The Tohoku journal of experimental medicine, 1991, Volume: 164, Issue:2

    Topics: Adult; Aerosols; Aged; Bradykinin; Captopril; Citrates; Citric Acid; Cough; Double-Blind Method; Enalapril; Female; Humans; Hypertension; Male; Middle Aged; Reflex; Respiratory Function Tests; Substance P

1991

Other Studies

50 other study(ies) available for substance p and Cough

ArticleYear
Gabapentin alleviated the cough hypersensitivity and neurogenic inflammation in a guinea pig model with repeated intra-esophageal acid perfusion.
    European journal of pharmacology, 2023, Nov-15, Volume: 959

    Topics: Animals; Cough; Gabapentin; Gastroesophageal Reflux; Guinea Pigs; Hydrochloric Acid; Lung; Neurogenic Inflammation; Perfusion; Receptors, Neurokinin-1; Substance P

2023
Effect of Qinbai Qingfei Concentrated Pellets on substance P and neutral endopeptidase of rats with post-infectious cough.
    BMC complementary medicine and therapies, 2020, Sep-22, Volume: 20, Issue:1

    Topics: Animals; Biomarkers; Cough; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Male; Neprilysin; Rats; Rats, Sprague-Dawley; Substance P

2020
Increased expression of transient receptor potential channels and neurogenic factors associates with cough severity in a guinea pig model.
    BMC pulmonary medicine, 2021, Jun-02, Volume: 21, Issue:1

    Topics: Animals; Bleomycin; Cough; Disease Models, Animal; Disease Progression; Guinea Pigs; Idiopathic Pulmonary Fibrosis; Lung; Male; Neurogenic Inflammation; Substance P; TRPA1 Cation Channel; TRPV Cation Channels

2021
Relationship Between Frequency of Spontaneous Swallowing and Salivary Substance P Level in Patients with Acute Stroke.
    Dysphagia, 2018, Volume: 33, Issue:4

    Topics: Aged; Cough; Deglutition; Female; Humans; Male; Middle Aged; Saliva; Stroke; Substance P

2018
The research of the possible mechanism and the treatment for capsaicin-induced cough.
    Pulmonary pharmacology & therapeutics, 2018, Volume: 49

    Topics: Animals; Antitussive Agents; Calcitonin Gene-Related Peptide; Capsaicin; Chronic Disease; Codeine; Cough; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Guinea Pigs; Male; Neurokinin A; Pyrrolidines; Substance P; TRPV Cation Channels; Urea

2018
Roles of citric acid in conjunction with saline nebulization in experimental tracheostomy in guinea pigs.
    Experimental lung research, 2018, Volume: 44, Issue:10

    Topics: Administration, Inhalation; Animals; Citric Acid; Cough; Guinea Pigs; Interleukin-6; Male; Nebulizers and Vaporizers; Respiratory Mucosa; Saline Solution; Substance P; Tracheostomy; Tumor Necrosis Factor-alpha

2018
Effect of anti-reflux treatment on gastroesophageal reflux-associated chronic cough: Implications of neurogenic and neutrophilic inflammation.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 2020, Volume: 57, Issue:11

    Topics: Adult; Aged; Chronic Disease; Cough; Female; Gastroesophageal Reflux; Humans; Inflammation; Leukocyte Count; Male; Middle Aged; Neutrophils; Prospective Studies; Proton Pump Inhibitors; Rabeprazole; Severity of Illness Index; Sputum; Substance P; Treatment Outcome; Visual Analog Scale

2020
Effects of four antitussives on airway neurogenic inflammation in a guinea pig model of chronic cough induced by cigarette smoke exposure.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2013, Volume: 62, Issue:12

    Topics: Animals; Antitussive Agents; Capsaicin; Codeine; Cough; Female; Flavanones; Guinea Pigs; Lung; Male; Neprilysin; Neurogenic Inflammation; Nicotiana; Propylene Glycols; Receptors, Neurokinin-1; Smoke; Substance P; Thiazolidines

2013
Effects of Qufeng Xuanfei decoction in animal model of post-infectious cough.
    Cell biochemistry and biophysics, 2014, Volume: 70, Issue:2

    Topics: Animals; Bronchoalveolar Lavage; Calcitonin Gene-Related Peptide; Cell Count; Cough; Disease Models, Animal; Drugs, Chinese Herbal; Infections; Lung; Male; Neurokinin A; Neurokinin B; Rats; Rats, Sprague-Dawley; Substance P

2014
Effect of transient receptor potential vanilloid-1 on cough hypersensitivity induced by particulate matter 2.5.
    Life sciences, 2016, Apr-15, Volume: 151

    Topics: Animals; Capillary Permeability; Capsaicin; Central Nervous System Diseases; Cough; Guinea Pigs; Herpesvirus 1, Suid; Hypersensitivity; Male; Particulate Matter; Respiratory Hypersensitivity; Signal Transduction; Substance P; TRPV Cation Channels; Vagus Nerve

2016
Effects of macrolides on antigen-induced increases in cough reflex sensitivity in guinea pigs.
    Pulmonary pharmacology & therapeutics, 2010, Volume: 23, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Antigens; Bronchoalveolar Lavage Fluid; Cough; Dinoprostone; Erythromycin; Guinea Pigs; Leukotriene B4; Macrolides; Male; Reflex; Substance P

2010
Encoding of the cough reflex in anesthetized guinea pigs.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2011, Volume: 300, Issue:2

    Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Anesthesia; Animals; Biphenyl Compounds; Citric Acid; Cough; Dose-Response Relationship, Drug; Electric Stimulation; GABA-A Receptor Antagonists; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Guinea Pigs; Male; Mechanoreceptors; Propionates; Quinoxalines; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Recurrent Laryngeal Nerve; Reflex; Respiratory Mucosa; Sensory Receptor Cells; Solitary Nucleus; Substance P; Trachea; Vagus Nerve; Valine

2011
Cough reflex sensitivity and airway inflammation in patients with chronic cough due to non-acid gastro-oesophageal reflux.
    Respirology (Carlton, Vic.), 2011, Volume: 16, Issue:4

    Topics: Adult; Aged; Asthma; Capsaicin; Chronic Disease; Cough; Cross-Sectional Studies; Female; Gastroesophageal Reflux; Histamine; Humans; Male; Middle Aged; Prospective Studies; Prostaglandin D2; Reflex; Respiratory Function Tests; Sputum; Substance P; Tryptases

2011
Plasma substance P levels in patients with persistent cough.
    Respiration; international review of thoracic diseases, 2011, Volume: 82, Issue:5

    Topics: Adult; Aged; Asthma; Cough; Enzyme-Linked Immunosorbent Assay; Female; Gastroesophageal Reflux; Humans; Male; Middle Aged; Respiratory Function Tests; Substance P

2011
Neuropeptide levels in nasal secretions from patients with and without chronic cough.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2011, Volume: 107, Issue:4

    Topics: Adult; Calcitonin Gene-Related Peptide; Case-Control Studies; Cough; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Nasal Mucosa; Neurokinin A; ROC Curve; Substance P

2011
Mechanism of the antitussive effect of azelastine in guinea pigs.
    Arzneimittel-Forschung, 2002, Volume: 52, Issue:6

    Topics: Animals; Antitussive Agents; Bronchoalveolar Lavage Fluid; Capsaicin; Cough; Female; Guinea Pigs; Phthalazines; Substance P; Trachea

2002
A study of the cough reflex in idiopathic pulmonary fibrosis.
    American journal of respiratory and critical care medicine, 2003, Oct-15, Volume: 168, Issue:8

    Topics: Aged; Anti-Inflammatory Agents; Bradykinin; Brain-Derived Neurotrophic Factor; Bronchial Provocation Tests; Capsaicin; Case-Control Studies; Cough; Female; Forced Expiratory Volume; Humans; Inflammation; Leukocyte Count; Male; Nerve Growth Factor; Neutrophils; Prednisolone; Pulmonary Fibrosis; Sputum; Substance P; Total Lung Capacity; Treatment Outcome

2003
Impaired efficacy of cough in patients with Parkinson disease.
    Chest, 2003, Volume: 124, Issue:3

    Topics: Aged; Cough; Disease Progression; Female; Humans; Middle Aged; Motor Neurons; Parkinson Disease; Peak Expiratory Flow Rate; Pneumonia, Aspiration; Reflex, Abnormal; Sensory Receptor Cells; Spirometry; Sputum; Substance P

2003
Elevated substance P levels in nasal lavage fluids from patients with chronic nonproductive cough and increased cough sensitivity to inhaled capsaicin.
    The Journal of allergy and clinical immunology, 2003, Volume: 112, Issue:4

    Topics: Administration, Inhalation; Adult; Capsaicin; Case-Control Studies; Cetirizine; Chronic Disease; Cough; Disease Susceptibility; Ephedrine; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Middle Aged; Nasal Decongestants; Nasal Lavage Fluid; Nasal Provocation Tests; Osmolar Concentration; Substance P

2003
Passive smoke effects on cough and airways in young guinea pigs: role of brainstem substance P.
    American journal of respiratory and critical care medicine, 2004, Feb-15, Volume: 169, Issue:4

    Topics: Aerosols; Age Factors; Animals; Brain Stem; Bronchoconstriction; Citric Acid; Cough; Guinea Pigs; Homocysteine; Injections; Lung; Male; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Respiration; Solitary Nucleus; Substance P; Tobacco Smoke Pollution

2004
Activation of the nociceptin/orphanin FQ receptor reduces bronchoconstriction and microvascular leakage in a rabbit model of gastroesophageal reflux.
    British journal of pharmacology, 2005, Volume: 144, Issue:6

    Topics: Animals; Bronchi; Bronchoconstriction; Capillary Permeability; Cough; Dose-Response Relationship, Drug; Female; Gastroesophageal Reflux; Hydrochloric Acid; Lung Compliance; Male; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Opioid Peptides; Rabbits; Receptors, Opioid; Substance P; Tachykinins; Trachea

2005
The role of substance P and bradykinin in the cough reflex and bronchoconstriction in guinea-pigs.
    European journal of pharmacology, 2005, Apr-18, Volume: 513, Issue:1-2

    Topics: Animals; Bradykinin; Bronchoconstriction; Citric Acid; Cough; Dose-Response Relationship, Drug; Glycopeptides; Guinea Pigs; Male; Oligopeptides; Protease Inhibitors; Reflex; Substance P; Time Factors

2005
Synergistic interactions between airway afferent nerve subtypes regulating the cough reflex in guinea-pigs.
    The Journal of physiology, 2005, Dec-01, Volume: 569, Issue:Pt 2

    Topics: Administration, Inhalation; Animals; Bradykinin; Bronchial Spasm; Capsaicin; Citric Acid; Cough; Guinea Pigs; Lung; Male; Mechanoreceptors; Microinjections; Nerve Fibers, Unmyelinated; Neurons, Afferent; Nociceptors; Reflex; Substance P; Tachykinins

2005
The role of excitatory amino acids and substance P in the mediation of the cough reflex within the nucleus tractus solitarii of the rabbit.
    Brain research bulletin, 2007, Sep-28, Volume: 74, Issue:4

    Topics: Animals; Cough; Electromyography; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Male; Microinjections; Neurons, Afferent; Physical Stimulation; Rabbits; Reflex; Respiration; Solitary Nucleus; Statistics, Nonparametric; Substance P

2007
Novel triple neurokinin receptor antagonist CS-003 strongly inhibits neurokinin related responses.
    European journal of pharmacology, 2008, May-31, Volume: 586, Issue:1-3

    Topics: Animals; Bronchi; Capillary Permeability; Capsaicin; Chlorocebus aethiops; Citric Acid; COS Cells; Cough; Cyclic S-Oxides; Dipeptides; Dose-Response Relationship, Drug; Guinea Pigs; Humans; In Vitro Techniques; Indoles; Inositol Phosphates; Male; Molecular Sequence Data; Morpholines; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Trachea

2008
Continued inhalation of lidocaine suppresses antigen-induced airway hyperreactivity and airway inflammation in ovalbumin-sensitized guinea pigs.
    International immunopharmacology, 2008, Volume: 8, Issue:5

    Topics: Administration, Inhalation; Anesthetics, Local; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Capsaicin; Cell Count; Cough; Eosinophils; Guinea Pigs; Histamine; Inflammation; Lidocaine; Lung; Male; Ovalbumin; Substance P

2008
Evidence for substance P as an endogenous substance causing cough in guinea pigs.
    The American review of respiratory disease, 1993, Volume: 148, Issue:6 Pt 1

    Topics: Aerosols; Animals; Capsaicin; Cough; Dipeptides; Dose-Response Relationship, Drug; Glycopeptides; Guinea Pigs; Indoles; Male; Neprilysin; Smoking; Substance P; Tachykinins

1993
Role of substance P in cough during bronchoconstriction in awake guinea pigs.
    American journal of respiratory and critical care medicine, 1995, Volume: 151, Issue:3 Pt 1

    Topics: Animals; Bronchial Provocation Tests; Bronchoconstriction; Consciousness; Cough; Dipeptides; Dose-Response Relationship, Drug; Guinea Pigs; Indoles; Male; Procaterol; Substance P

1995
Neurokinin A, but not neurokinin B and substance P, induces codeine-resistant coughs in awake guinea-pigs.
    Regulatory peptides, 1993, Jul-02, Volume: 46, Issue:1-2

    Topics: Animals; Capsaicin; Codeine; Cough; Dose-Response Relationship, Drug; Drug Resistance; Guinea Pigs; Male; Neurokinin A; Neurokinin B; Substance P

1993
Involvement of substance P in the paroxysmal cough of pertussis.
    Regulatory peptides, 1993, Jul-02, Volume: 46, Issue:1-2

    Topics: Asthma; Child; Cough; Humans; Radioimmunoassay; Reference Values; Substance P; Whooping Cough

1993
Abnormal intraepithelial airway nerves in persistent unexplained cough?
    American journal of respiratory and critical care medicine, 1995, Volume: 152, Issue:6 Pt 1

    Topics: Adult; Aged; Bronchi; Bronchoscopy; Calcitonin Gene-Related Peptide; Capsaicin; Cough; Epithelium; Female; Humans; Immunohistochemistry; Male; Middle Aged; Nerve Tissue Proteins; Substance P; Thiolester Hydrolases; Ubiquitin Thiolesterase

1995
Angiotensin-converting enzyme inhibitor and danazol increase sensitivity of cough reflex in female guinea pigs.
    American journal of respiratory and critical care medicine, 1996, Volume: 153, Issue:2

    Topics: Adrenergic beta-Agonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Capsaicin; Cilazapril; Citrates; Citric Acid; Cough; Cyclic AMP; Danazol; Dipeptides; Dose-Response Relationship, Drug; Estrogen Antagonists; Female; Guinea Pigs; Indoles; Procaterol; Reflex; Sex Factors; Substance P; Trachea

1996
Antitussive and antibronchoconstriction actions of fenspiride in guinea-pigs.
    The European respiratory journal, 1995, Volume: 8, Issue:10

    Topics: Acetates; Acetic Acid; Aerosols; Airway Resistance; Animals; Antitussive Agents; Bronchoconstriction; Bronchodilator Agents; Capsaicin; Cough; Dose-Response Relationship, Drug; Guinea Pigs; Male; Neurokinin A; Spiro Compounds; Substance P

1995
Further characterisation of substance P induced histamine release from human bronchoalveolar lavage mast cells.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45 Suppl 1

    Topics: Anti-Bacterial Agents; Antimetabolites; Antimycin A; Asthma; Bronchoalveolar Lavage Fluid; Buffers; Calcium; Cough; Deoxyglucose; Glucose; Histamine Release; Humans; Mast Cells; Substance P

1996
Angiotensin converting enzyme (ACE) inhibitor-induced cough and substance P.
    Thorax, 1996, Volume: 51, Issue:2

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Cough; Enalapril; Female; Humans; Hypertension; Male; Middle Aged; Sputum; Substance P; Time Factors

1996
Afferent reinnervation after lung transplantation in the rat.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 1998, Volume: 17, Issue:4

    Topics: Animals; Bacterial Infections; Bradycardia; Calcitonin Gene-Related Peptide; Capsaicin; Cough; Denervation; Fluorescent Dyes; Follow-Up Studies; Immunohistochemistry; Incidence; Lung; Lung Transplantation; Male; Nerve Fibers; Nerve Regeneration; Neurons, Afferent; Nodose Ganglion; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Inbred Lew; Reflex; Stilbamidines; Substance P; Time Factors; Transplantation, Isogeneic; Vagus Nerve

1998
ACE inhibitors and symptomless dysphagia.
    Lancet (London, England), 1998, Jul-11, Volume: 352, Issue:9122

    Topics: Angiotensin-Converting Enzyme Inhibitors; Case-Control Studies; Cerebral Hemorrhage; Cerebral Infarction; Cough; Deglutition Disorders; Female; Humans; Hypertension; Male; Substance P

1998
Sensory neuropeptides induce histamine release from bronchoalveolar lavage cells in both nonasthmatic coughers and cough variant asthmatics.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2000, Volume: 30, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Bronchoalveolar Lavage Fluid; Calcimycin; Calcitonin Gene-Related Peptide; Cough; Female; Histamine Release; Humans; Male; Mast Cells; Middle Aged; Neuropeptides; Substance P

2000
Role of substance P and tachykinin receptor antagonists in citric acid-induced cough in pigs.
    European journal of pharmacology, 2000, Nov-24, Volume: 408, Issue:3

    Topics: Animals; Benzamides; Citric Acid; Cough; Female; Lung; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Reflex; Substance P; Swine, Miniature

2000
Inhibiting effect of ammonia on citric acid-induced cough in pigs: a possible involvement of substance P.
    Pharmacology & toxicology, 2000, Volume: 87, Issue:6

    Topics: Ammonia; Animals; Bronchoalveolar Lavage Fluid; Citric Acid; Cough; Female; Male; Mucous Membrane; Nebulizers and Vaporizers; Respiratory System; Substance P; Swine

2000
[No relation between angiotensin-converting enzyme (ACE) inhibitor-induced cough and ACE gene polymorphism, plasma bradykinin, substance P and ACE inhibitor concentration in Japanese patients].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2001, Volume: 121, Issue:3

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Bradykinin; Chronic Disease; Cough; Female; Humans; Hypertension; Indoles; Male; Middle Aged; Nephritis; Peptidyl-Dipeptidase A; Polymorphism, Genetic; Substance P

2001
Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 300, Issue:1

    Topics: Acetates; Animals; Antitussive Agents; Behavior, Animal; Bronchial Hyperreactivity; Calcium; Central Nervous System; Citric Acid; Cloning, Molecular; Cough; Guinea Pigs; In Vitro Techniques; Iris; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Pupil; Quinolines; Rabbits; Radioligand Assay; Rats; Receptors, Neurokinin-3; Receptors, Tachykinin; Recombinant Proteins; Substance P

2002
[Cough as a side effect of angiotensin-converting enzyme inhibitors].
    Nederlands tijdschrift voor geneeskunde, 1992, Sep-19, Volume: 136, Issue:38

    Topics: Angiotensin-Converting Enzyme Inhibitors; Bradykinin; Bronchial Hyperreactivity; Cough; Dinoprostone; Humans; Substance P

1992
[Cough reflex in respiratory disease].
    Nihon Kyobu Shikkan Gakkai zasshi, 1990, Volume: 28, Issue:1

    Topics: Aged; Bradykinin; Cough; Female; Humans; Male; Pneumonia, Aspiration; Reflex; Respiratory Tract Infections; Substance P

1990
[Abnormalities in cough reflex].
    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 1991, Volume: 28, Issue:3

    Topics: Aging; Bronchitis; Cough; Female; Humans; Male; Neprilysin; Pneumonia, Aspiration; Reflex; Substance P

1991
Angiotensin-converting enzyme inhibition, cough and the serum concentration of substance P.
    European journal of clinical pharmacology, 1988, Volume: 34, Issue:6

    Topics: Angiotensin-Converting Enzyme Inhibitors; Cough; Enalapril; Humans; Hypertension; Substance P

1988
Neutral endopeptidase inhibitors potentiate substance P- and capsaicin-induced cough in awake guinea pigs.
    The Journal of clinical investigation, 1988, Volume: 82, Issue:6

    Topics: Animals; Capsaicin; Cough; Drug Synergism; Glycopeptides; Guinea Pigs; Male; Neprilysin; Substance P; Thiorphan

1988
[Neuropeptide-induced cough in humans].
    Kokyu to junkan. Respiration & circulation, 1989, Volume: 37, Issue:5

    Topics: Animals; Asthma; Bronchitis; Cough; Humans; Substance P

1989
Recombinant human enkephalinase (neutral endopeptidase) prevents cough induced by tachykinins in awake guinea pigs.
    The Journal of clinical investigation, 1989, Volume: 84, Issue:3

    Topics: Aerosols; Animals; Antitussive Agents; Capsaicin; Cough; Guinea Pigs; Humans; Liposomes; Male; Neprilysin; Recombinant Proteins; Sodium Chloride; Substance P; Tachykinins

1989
Inhibitory actions of procaterol, a beta-2 stimulant, on substance P-induced cough in normal subjects during upper respiratory tract infection.
    The Tohoku journal of experimental medicine, 1989, Volume: 158, Issue:1

    Topics: Adrenergic beta-Agonists; Adult; Cough; Ethanolamines; Female; Forced Expiratory Volume; Humans; Male; Procaterol; Respiratory Tract Infections; Substance P

1989