substance p has been researched along with Benign Neoplasms, Brain in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (8.11) | 18.7374 |
| 1990's | 12 (32.43) | 18.2507 |
| 2000's | 7 (18.92) | 29.6817 |
| 2010's | 13 (35.14) | 24.3611 |
| 2020's | 2 (5.41) | 2.80 |
| Authors | Studies |
|---|---|
| Bruchertseifer, F; Koziara, H; Królicki, L; Kuliński, R; Kunikowska, J; Merlo, A; Morgenstern, A; Pawlak, D; Rola, R | 1 |
| Inada, E; Iseki, M; Kumakura, S; Nagaoka, I; Someya, A; Yamaguchi, K; Yamazaki, S | 1 |
| Chen, Q; Guo, Q; He, X; Jiang, C; Jiang, X; Liu, L; Liu, Y; Lu, Y; Ruan, C; Sun, T; Wang, Q; Zhang, Y | 1 |
| Apostolidis, C; Bruchertseifer, F; Jakuciński, M; Koziara, H; Królicki, B; Krolicki, L; Kunikowska, J; Merlo, A; Mirzadeh, S; Morgenstern, A; Pawlak, D; Rola, R | 1 |
| Cordier, D; Merlo, A | 1 |
| Harford-Wright, E; Lewis, KM; Vink, R | 1 |
| Ghabriel, MN; Harford-Wright, E; Lewis, KM; Vink, R | 3 |
| Bauman, A; Cordier, D; Gerber, A; Hutter, G; Kluba, C; Mariani, L; Mindt, TL | 1 |
| Harford-Wright, E; Lewis, KM; Mander, K; Vink, R | 1 |
| Demir, N; Erin, N; Kale, Ş; Köksoy, S; Korcum, AF; Tanrıöver, G | 1 |
| Dalaklioglu, S; Erin, N | 1 |
| Akazawa, T; Cox, EA; Goldsmith, LE; Kwatra, MM; Kwatra, SG; Richardson, MD; Sampson, JH | 1 |
| Cordier, D; Forrer, F; Kneifel, S; Mäcke, H; Mariani, L; Merlo, A; Müller-Brand, J; Sailer, M | 1 |
| Ghabriel, MN; Harford-Wright, E; Lewis, KM; Nimmo, AJ; Vink, R | 1 |
| GRABNER, K; LEMBECK, F | 1 |
| Castro, E; Coveñas, R; Muñoz, M; Pérez, A; Rosso, M | 1 |
| Coveñas, R; Muñoz, M; Pérez, A; Piruat, JI; Rosso, M; Rosso, R; Zamarriego, C | 1 |
| Bernhardt, P; Buitrago-Téllez, C; Good, S; Kneifel, S; Mäcke, H; Merlo, A; Müller-Brand, J; Plasswilm, L; Uusijärvi, H | 1 |
| Lipkowski, A; Matyja, E; Łazarczyk, M | 1 |
| Busek, P; Krepela, E; Sedo, A; Stremeňová, J | 1 |
| Barann, M; Bönisch, H; Göthert, M; Ruppert, K | 1 |
| Dimlich, RV; Gruenstein, E; Medrano, S | 1 |
| Goso, C; Manzini, S; Palma, C | 1 |
| Bordey, A; Feltz, P; Trouslard, J | 1 |
| Brenner, JW; Gokden, M; Lorenz, RG; Roth, KA; Selznick, LA | 1 |
| Bouthillier, A; Nguyen, TD; Thorin, E | 1 |
| Sharif, M | 1 |
| Gibson, WJ; Pinnock, RD; Young, JM; Young, KW | 1 |
| Manzini, S; Palma, C | 1 |
| Maggi, CA; Palma, C | 1 |
| De Tribolet, N; Hornung, JP; Törk, I | 1 |
| Lee, CM; Tung, WL; Young, JD | 1 |
| Johnson, CG; Johnson, CL | 1 |
| Allen, JM; Bloom, SR; Ghatei, MA; Hoyle, NR; Thomas, DG; Yeats, JC | 1 |
| Röding, T; Schädlich, M | 1 |
5 review(s) available for substance p and Benign Neoplasms, Brain
| Article | Year |
|---|---|
The potential for substance P antagonists as anti-cancer agents in brain tumours.
Topics: Antineoplastic Agents; Blood-Brain Barrier; Brain Edema; Brain Neoplasms; Humans; Models, Neurological; Molecular Targeted Therapy; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Substance P | 2013 |
Advancing drug therapy for brain tumours: a current review of the pro-inflammatory peptide Substance P and its antagonists as anti-cancer agents.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Humans; Receptors, Neurokinin-1; Substance P | 2014 |
Substance P and its receptors -- a potential target for novel medicines in malignant brain tumour therapies (mini-review).
Topics: Amino Acid Sequence; Antineoplastic Agents; Brain Neoplasms; Drug Design; Humans; Receptors, Neurokinin-1; Receptors, Tachykinin; Substance P; Tachykinins | 2007 |
Mitogenic signaling by substance P and bombesin-like neuropeptide receptors in astrocytic/glial brain tumor-derived cell lines.
Topics: Adult; Astrocytoma; Bombesin; Brain Neoplasms; Cell Division; Child; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Mitogens; Receptors, Neuropeptide; Signal Transduction; Sirolimus; Substance P; Tamoxifen; Tumor Cells, Cultured | 1998 |
The role of tachykinins via NK1 receptors in progression of human gliomas.
Topics: Animals; Brain Neoplasms; Disease Progression; Glioma; Humans; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Substance P | 2000 |
1 trial(s) available for substance p and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Neoadjuvant targeting of glioblastoma multiforme with radiolabeled DOTAGA-substance P--results from a phase I study.
Topics: Adult; Aged; Brain Neoplasms; Combined Modality Therapy; Diagnostic Imaging; Female; Follow-Up Studies; Glioblastoma; Heterocyclic Compounds, 1-Ring; Humans; Male; Middle Aged; Neoadjuvant Therapy; Organometallic Compounds; Radiopharmaceuticals; Substance P | 2010 |
31 other study(ies) available for substance p and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Locoregional Treatment of Glioblastoma With Targeted α Therapy: [ 213 Bi]Bi-DOTA-Substance P Versus [ 225 Ac]Ac-DOTA-Substance P-Analysis of Influence Parameters.
Topics: Adult; Brain Neoplasms; Glioblastoma; Heterocyclic Compounds, 1-Ring; Humans; Middle Aged; Substance P | 2023 |
Yokukansan, a Japanese Herbal Medicine, Suppresses Substance PInduced Production of Interleukin-6 and Interleukin-8 by Human U373 MG Glioblastoma Astrocytoma Cells.
Topics: Anti-Inflammatory Agents; Astrocytoma; Brain Neoplasms; Cell Line, Tumor; Drugs, Chinese Herbal; Glioblastoma; Herb-Drug Interactions; Herbal Medicine; Humans; Interleukin-6; Interleukin-8; Japan; Neuritis; Neuroimmunomodulation; Neuroprotective Agents; Signal Transduction; Substance P | 2020 |
Substance P Mediated DGLs Complexing with DACHPt for Targeting Therapy of Glioma.
Topics: Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Drug Delivery Systems; Glioma; Humans; Lysine; Substance P | 2017 |
Prolonged survival in secondary glioblastoma following local injection of targeted alpha therapy with
Topics: Adult; Bismuth; Brain Neoplasms; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Organometallic Compounds; Positron Emission Tomography Computed Tomography; Radioisotopes; Substance P; Survival Analysis; Tissue Distribution; Young Adult | 2018 |
Long-Term Results of Targeted Low-Grade Glioma Treatment with
Topics: Adult; Astrocytoma; Brain Neoplasms; Female; Humans; Neoplasm Recurrence, Local; Organometallic Compounds; Prognosis; Substance P | 2019 |
Evaluating the role of substance P in the growth of brain tumors.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Death; Cell Line, Tumor; Cell Survival; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunohistochemistry; Male; Melanoma; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Substance P; Xenograft Model Antitumor Assays | 2014 |
Expression of different neurokinin-1 receptor (NK1R) isoforms in glioblastoma multiforme: potential implications for targeted therapy.
Topics: Brain Neoplasms; Cell Line, Tumor; Glioblastoma; Humans; Molecular Targeted Therapy; Protein Isoforms; Receptors, Neurokinin-1; Substance P | 2014 |
Treatment with the NK1 antagonist emend reduces blood brain barrier dysfunction and edema formation in an experimental model of brain tumors.
Topics: Animals; Aprepitant; Blood-Brain Barrier; Brain Edema; Brain Neoplasms; Disease Models, Animal; Humans; Male; Mice; Morpholines; Neurokinin-1 Receptor Antagonists; Permeability; Receptors, Neurokinin-1; Substance P | 2014 |
Activation of neuroimmune pathways increases therapeutic effects of radiotherapy on poorly differentiated breast carcinoma.
Topics: Animals; Brain Neoplasms; Breast Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Disease Models, Animal; Docetaxel; Female; Mice; Mice, Inbred BALB C; Substance P; Taxoids; Treatment Outcome | 2015 |
Substance P Prevents Vascular Endothelial Dysfunction in Metastatic Breast Carcinoma.
Topics: Acetylcholine; Animals; Antioxidants; Aorta, Thoracic; Brain Neoplasms; Breast Neoplasms; Cell Line, Tumor; Endothelium, Vascular; Female; Mice; Mice, Inbred BALB C; Nitroprusside; Oxidative Stress; Phenylephrine; Potassium Chloride; Substance P | 2016 |
A constitutively active form of neurokinin 1 receptor and neurokinin 1 receptor-mediated apoptosis in glioblastomas.
Topics: Apoptosis; Brain Neoplasms; Cell Line, Tumor; Culture Media, Conditioned; Dose-Response Relationship, Drug; Glioblastoma; Humans; Immunohistochemistry; Neurokinin-1 Receptor Antagonists; Oncogene Protein v-akt; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptors, Neurokinin-1; Substance P | 2009 |
Walker 256 tumour cells increase substance P immunoreactivity locally and modify the properties of the blood-brain barrier during extravasation and brain invasion.
Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Capillary Permeability; Carcinoma 256, Walker; Female; Immunohistochemistry; Male; Mammary Neoplasms, Animal; Rats; Rats, Wistar; Substance P; Tumor Cells, Cultured | 2013 |
Targeting classical but not neurogenic inflammation reduces peritumoral oedema in secondary brain tumours.
Topics: Animals; Anti-Inflammatory Agents; Blood-Brain Barrier; Brain Edema; Brain Neoplasms; Dexamethasone; Disease Models, Animal; Inflammation; Male; Neurokinin-1 Receptor Antagonists; Rats; Rats, Wistar; Substance P | 2012 |
[Studies on the content of substance P and serotonin in brain tumors].
Topics: Brain Chemistry; Brain Neoplasms; Neoplasms; Serotonin; Substance P | 1960 |
Antitumoural action of L-733,060 on neuroblastoma and glioma cell lines.
Topics: Antineoplastic Agents; Brain Neoplasms; Cell Division; Cell Line, Tumor; Dose-Response Relationship, Drug; Glioma; Humans; Neuroblastoma; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Substance P | 2004 |
The NK1 receptor is involved in the antitumoural action of L-733,060 and in the mitogenic action of substance P on neuroblastoma and glioma cell lines.
Topics: Antineoplastic Agents; Brain Neoplasms; Cell Division; Cell Line, Tumor; Glioma; Humans; Mitogens; Neuroblastoma; Piperidines; Receptors, Neurokinin-1; Substance P | 2005 |
Individual voxelwise dosimetry of targeted 90Y-labelled substance P radiotherapy for malignant gliomas.
Topics: Adult; Aged; Antigens, Neoplasm; Brain; Brain Neoplasms; Cell Adhesion Molecules; Epithelial Cell Adhesion Molecule; Female; Glioma; Humans; Ligands; Male; Middle Aged; Models, Statistical; Models, Theoretical; Radiometry; Radiotherapy; Regression Analysis; Substance P; Tomography, X-Ray Computed; Yttrium Radioisotopes | 2007 |
Modulation of substance P signaling by dipeptidyl peptidase-IV enzymatic activity in human glioma cell lines.
Topics: Brain Neoplasms; Calcium Signaling; Chemokine CXCL12; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Glioma; Humans; Lysine; Mifepristone; Oligopeptides; Pyrrolidines; Serine Proteinase Inhibitors; Substance P; Transfection; U937 Cells | 2008 |
Increasing effect of ethanol on 5-HT3 receptor-mediated 14C-guanidinium influx in N1E-115 neuroblastoma cells.
Topics: Alcohols; Animals; Binding, Competitive; Brain Neoplasms; Ethanol; Guanidine; Guanidines; Imidazoles; Indoles; Mice; Neuroblastoma; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Sodium Channels; Substance P; Tumor Cells, Cultured; Veratridine | 1995 |
Substance P receptors on human astrocytoma cells are linked to glycogen breakdown.
Topics: Astrocytoma; Biphenyl Compounds; Brain Neoplasms; Dose-Response Relationship, Drug; Drug Combinations; Glycogen; Histamine; Humans; Norepinephrine; Receptors, Neurokinin-1; Substance P; Tumor Cells, Cultured | 1994 |
Different susceptibility to neurokinin 1 receptor antagonists of substance P and septide-induced interleukin-6 release from U373 MG human astrocytoma cell line.
Topics: Astrocytoma; Binding, Competitive; Brain Neoplasms; Humans; Interleukin-6; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Pyrrolidonecarboxylic Acid; Substance P; Tumor Cells, Cultured | 1994 |
Mobilization of intracellular calcium by substance P in a human astrocytoma cell line (U-373 MG).
Topics: Astrocytoma; Brain Neoplasms; Calcium; Cytosol; Fura-2; Humans; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1994 |
Enzyme-based antigen localization and quantitation in cell and tissue samples (Midwestern assay).
Topics: Alzheimer Disease; Animals; Antibodies, Antinuclear; Brain Neoplasms; Bromodeoxyuridine; Cytoskeletal Proteins; DNA; Enzyme-Linked Immunosorbent Assay; Glial Fibrillary Acidic Protein; Humans; Ki-67 Antigen; Mice; Spinal Cord; Substance P; tau Proteins; Tumor Cells, Cultured | 1997 |
Control of vascular tone by endogenous endothelin-1 in human pial arteries.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Arteries; Brain Neoplasms; Cerebral Cortex; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Epilepsy; Female; Glyburide; Humans; Hypoglycemic Agents; Male; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxymetazoline; Peptides, Cyclic; Pia Mater; Potassium Channel Blockers; Serotonin; Substance P; Tetraethylammonium; Vasoconstrictor Agents; Vasodilator Agents | 1998 |
Dual effects of histamine and substance P on intracellular calcium levels in human U373 MG astrocytoma cells: role of protein kinase C.
Topics: Animals; Astrocytoma; Brain Neoplasms; Calcium; Cerebellum; Colforsin; Cyclic AMP; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Guinea Pigs; HeLa Cells; Histamine; Humans; Inositol Phosphates; Protein Kinase C; Pyrilamine; Substance P; Thapsigargin; Tritium; Tumor Cells, Cultured | 1998 |
Substance P induces secretion of immunomodulatory cytokines by human astrocytoma cells.
Topics: Astrocytoma; Brain Neoplasms; Cytokines; Dipeptides; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Inhibitors; Humans; Indoles; Interleukin-6; Interleukin-8; Leukemia Inhibitory Factor; Lymphokines; Neoplasm Proteins; Neurokinin-1 Receptor Antagonists; Protein Kinase C; Receptors, Neurokinin-1; RNA, Messenger; RNA, Neoplasm; Staurosporine; Substance P; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Morphology and distribution of neuropeptide-containing neurons in human cerebral cortex.
Topics: Axons; Brain Neoplasms; Cerebral Cortex; Cholecystokinin; Frontal Lobe; Humans; Immunohistochemistry; Neurons; Neuropeptide Y; Neuropeptides; Occipital Lobe; Parietal Lobe; Somatostatin; Substance P; Temporal Lobe | 1992 |
Tachykinin-stimulated inositol phospholipid hydrolysis and taurine release from human astrocytoma cells.
Topics: Alkaloids; Astrocytoma; Brain Neoplasms; Down-Regulation; Humans; Hydrolysis; Phosphatidylinositols; Protein Kinase C; Receptors, Neurotransmitter; Receptors, Tachykinin; Staurosporine; Substance P; Tachykinins; Taurine; Tetradecanoylphorbol Acetate; Tritium; Tumor Cells, Cultured | 1992 |
Tumor necrosis factor and interleukin-1 down-regulate receptors for substance P in human astrocytoma cells.
Topics: Astrocytoma; Brain Neoplasms; Down-Regulation; Histamine; Humans; Inositol Phosphates; Interleukin-1; Kinetics; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1991 |
Neuropeptides in neurological tumours.
Topics: Astrocytoma; Bombesin; Brain Neoplasms; Humans; Meningeal Neoplasms; Nerve Tissue Proteins; Neuropeptide Y; Substance P; Vasoactive Intestinal Peptide | 1985 |
[Substance P--perioperative plasma level in patients with intracranial tumors--a first pilot study].
Topics: Adult; Arousal; Brain Neoplasms; Female; Humans; Male; Pilot Projects; Substance P | 1988 |