substance p has been researched along with Anasarca in 125 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (15.20) | 18.7374 |
| 1990's | 57 (45.60) | 18.2507 |
| 2000's | 28 (22.40) | 29.6817 |
| 2010's | 17 (13.60) | 24.3611 |
| 2020's | 4 (3.20) | 2.80 |
| Authors | Studies |
|---|---|
| Appell, KC; Goswami, R; Lawrence, KB; Logan, ME; Tomczuk, BE; Venepalli, BR; Yanni, JM | 1 |
| Argunhan, F; Brain, SD; Chaudhry, H; de Sousa Valente, J; Ghanim, H; Zarban, AA | 1 |
| He, J; Zheng, S | 1 |
| Fukushige, R; Hisaoka-Nakashima, K; Kishida, Y; Morioka, N; Nakamura, Y; Nakata, Y; Watanabe, K | 1 |
| Camargo, LL; Cerqueira, ARA; Costa, SKP; Denadai-Souza, A; Fernandes, ES; Ferro, ES; Gewehr, MCF; Lima, C; Muscará, MN; Schenka, AA; Teixeira, SA; Yshii, LM | 1 |
| Barry, CM; Haberberger, RV; Ji, E; Kyloh, M; Sharma, H; Spencer, NJ; Vilimas, P; Yap, P | 1 |
| Berger, A; Borbély, E; Hajna, Z; Helyes, Z; Kereskai, L; Nagy, P; Paige, C; Pintér, E; Quinn, J; Sándor, K; Stewart, J; Szolcsányi, J; Tóth, I; Zimmer, A | 1 |
| Leonard, AV; Thornton, E; Vink, R | 1 |
| Banki, E; Bolcskei, K; Botz, B; Hajna, Z; Helyes, Z; Kemeny, A; Nagy, P; Reglodi, D; Toth, G | 1 |
| Bi, Y; Huang, B; Li, Q; Tian, M; Xu, F; Xu, S; Zhen, X | 1 |
| Bhatia, M | 1 |
| Clark, DJ; Guo, TZ; Kingery, WS; Li, WW; Shi, X; Sun, Y; Wei, T | 1 |
| Borbély, É; Helyes, Z; Kemény, Á; Markovics, A; McDougall, JJ; Pintér, E; Quinn, JP; Sándor, K; Szolcsányi, J | 1 |
| Almeida, MPA; Bakhle, YS; Frade, TIC; Francischi, JN; Queiroz, BFG | 1 |
| Birklein, F; He, L; Krämer, HH; Lu, B; Sommer, C | 1 |
| Barbosa, AL; Moraes, MO; Oliveira, GJ; Pinheiro, CA; Ribeiro, RA; Souza, MH; Vale, ML | 1 |
| Clark, DJ; Guo, TZ; Kingery, WS; Li, WW; Oaklander, AL; Schmelz, M; Wang, L; Wei, T; Zhao, R | 1 |
| Barreto, SG; Carati, CJ; Saccone, GT; Schloithe, AC; Toouli, J | 1 |
| Biavatti, MW; Bürger, C; Busnardo, TC; Claudino, VD; Dalmarco, EM; de Souza, MM; Fröde, TS; Mora, TC; Padoani, C | 1 |
| Ikeda, T; Matsushima, O; Naono-Nakayama, R; Nishimori, T; Sunakawa, N | 1 |
| Appenzeller, M; Bigliardi, P; Buclin, T; Grouzmann, E; Pannatier, A | 1 |
| Bodkin, JV; Brain, SD; Fernandes, E; O'Byrne, KT; Sawyer, I; Smillie, SJ | 1 |
| Arcanjo, DD; Guimarães, AG; Machado, FD; Oliveira, FA; Oliveira, RC; Quintans-Júnior, LJ; Silva, ER; Silva, FV; Sousa-Neto, BP | 1 |
| Assreuy, AM; Coelho-de-Souza, AN; Leal-Cardoso, JH; Ponte, EL; Rocha, MV; Soares, PM; Sousa, PL | 1 |
| Akcal, A; Kaya, H; Kiyak, V; Sakiz, D; Sevim, KZ; Sucu, DO; Tatlidede, HS; Yesilada, A | 1 |
| Ashton, D; Fransen, JF; Hens, KA; Heylen, L; Hillen, LC; Janssens, F; Jurzak, MR; Leysen, JE; Mahieu, M; Megens, AA; Vermeire, JC; Vermote, PC | 1 |
| Akhtar, R; Brain, SD; Gerard, NP; Grant, AD | 1 |
| Lam, FF; Ng, ES; Wong, HH | 1 |
| Boyd, EA; Guo, TZ; Jacobs, CR; Kingery, WS; Offley, SC | 1 |
| Basbaum, AI; Giese, KP; Silva, AJ; Zeitz, KP | 1 |
| Nies, M; Ro, JY; Zhang, Y | 1 |
| Hu, JH; Li, FQ; Liu, JY; Sun, HJ; Zhu, QG | 1 |
| Chen, WL; Zhang, YQ; Zhao, ZQ | 1 |
| Wang, Gf | 1 |
| Cavalcante, IJ; Lima, MA; Maia, JL; Melo, CM; Rao, VS; Santos, FA; Silveira, ER; Vieira, GA | 1 |
| Brain, SD; Costa, SK; Gilmore, D; Hyslop, S; Starr, A | 1 |
| Bauer, JD; Cutler, SJ; Foster, MS; May, SW; Ogonowski, AA; Pollock, SH; Sunman, JA; Thompson, JR | 1 |
| Green, C; Hewlett, E; Hughes, M; Padgett, D; Schwartz, L; Tessier, J; Zhao, W | 1 |
| Andrade-Gordon, P; D'Andrea, MR; Davis, CA; Derian, CK; Dozmorov, I; Hurst, RE; Ihnat, MA; Saban, MR; Saban, R; Simpson, C | 1 |
| Rubinstein, I | 1 |
| Bianchi, M; Ferrario, P; Franchi, S; Sacerdote, P; Sotgiu, ML | 1 |
| Finke, B; Gierer, P; Gradl, G; Mittlmeier, T; Schattner, S; Vollmar, B | 1 |
| Fang, L; Li, D; Lin, Q; Xu, X; Zou, X | 1 |
| Gibson, SJ; McMahon, SB; Sykova, E; Wall, PD; Woolf, CJ | 1 |
| Felder, M | 1 |
| Chahl, LA; Walker, SB | 1 |
| Chahl, LA; Morton, CR | 1 |
| Chahl, LA; Manley, SW | 1 |
| Fitzgerald, M | 1 |
| Folkers, K; Lundberg, JM; Martling, CR; Rosell, S; Saria, A | 1 |
| Folkers, K; Lundberg, JM; Rosell, S; Saria, A | 1 |
| Saria, A | 1 |
| Anggård, A; Lundberg, JM; Lundblad, L; Saria, A | 1 |
| Inoue, H; Koshihara, Y; Nagata, N | 6 |
| McDonald, DM; Sulakvelidze, I | 1 |
| Galeazza, MT; Seybold, VS; Stucky, CL | 1 |
| Erion, MD; Gilligan, JP; Jeng, AY; Lovato, SJ | 1 |
| Brain, SD; Euzger, H; Wilsoncroft, P | 1 |
| Chang, LC; Kuo, SC; Raung, SL; Wang, JP | 1 |
| Brain, SD; Newbold, P | 2 |
| Nourshargh, S; Walsh, DT; Weg, VB; Williams, TJ | 1 |
| Benrath, J; Eschenfelder, C; Gillardon, F; Zimmerman, M | 1 |
| Benrath, J; Eschenfelder, CC; Gillardon, F; Zimmermann, M | 1 |
| Alessandri, M; Fanciullacci, M; Fedi, S; Pietrini, U | 1 |
| Bertrand, C; Desai, MC; Geppetti, P; Nadel, JA; Piedimonte, G; Snider, RM | 1 |
| Fujii, T; Hagiwara, D; Maeda, Y; Matsuo, M; Miyake, H; Murai, M; Yamaoka, M | 1 |
| Asai, R; Kanai, Y; Murase, A; Nagahisa, A; Nakagaki, T; Shieh, TC; Taniguchi, K; Tsuchiya-Nakagaki, M | 1 |
| Higham, MA; Ind, PW; Iredale, MJ; Sharara, AM | 1 |
| Ahluwalia, A; Giuliani, S; Maggi, CA | 1 |
| Berti, F; Bianchi, M; Panerai, AE; Rossoni, G; Sacerdote, P | 2 |
| Antunes, E; Brain, SD; Costa, SK; de Nucci, G; Palframan, RT; Wilsoncroft, P | 1 |
| Bae, MA; Cho, HJ; Kim, JK; Park, EH | 1 |
| Canella, R; Leon, A; Marcolongo, G; Mazzari, S; Petrelli, L | 1 |
| Amann, R; Donnerer, J; Herzeg, G; Schuligoi, R | 1 |
| Bernat, A; Herbert, JM | 1 |
| Zawieja, DC | 1 |
| Brain, SD; Siney, L | 1 |
| Inoue, H; Koshihara, Y; Nagata, N; Shibata, S | 1 |
| Bourdon, V; Damas, J; Liégeois, JF; Simmons, WH | 1 |
| Chen, YH; Kuo, SC; Wang, JP | 1 |
| Barrett, LT; May, SW; Moore, AB; O'Bryant, CL; Ogonowski, AA; Pollock, SH | 1 |
| Hore, SK; Kumar, D; Tandan, SK; Tripathi, HC | 1 |
| Bourdon, V; Damas, J; Liégeois, JF | 1 |
| Rao, VS; Santos, FA | 1 |
| Brain, SD; Towler, PK | 1 |
| Brain, SD; Brown, B; Hoult, JR; Pintér, E | 1 |
| Löfgren, O; Lundeberg, T; Qi, Y | 1 |
| Castellote, JM; Kingery, WS; Maze, M | 1 |
| Brain, SD; Cao, T; Gerard, NP | 1 |
| Harper, RP; Hinton, RJ; Hutchins, B; Spears, R | 1 |
| Bunnett, NW; Gerard, C; Gerard, N; Grady, EF; Kim, EH; Kirkwood, KS; Maa, J; Rahim, S; Valeroso, D; Vartanian, RK; Yoshimi, SK | 1 |
| Igeta, K; Inagaki, N; Kawasaki, H; Musoh, K; Nagai, H; Nagao, M; Nakamura, N | 1 |
| Calixto, JB; Campos, MM | 1 |
| Cabrini, DA; Calixto, JB; Campos, MM; Cardozo, AH; Rae, GA; Toro, JH | 1 |
| Brain, SD; Cao, T; Gerard, NP; Grant, AD | 1 |
| Salam, OM | 1 |
| Cappugi, P; Lotti, T; Tsampau, D | 1 |
| Fujii, T; Kiyotoh, S; Maeda, Y; Morimoto, H; Murai, M; Nishikawa, M | 1 |
| Garry, MG; Hargreaves, KM | 1 |
| Brain, SD; Cambridge, H | 1 |
| Fujii, T; Hashimoto, M; Hayashi, K; Imanaka, H; Kiyoto, S; Kohsaka, M; Murai, M; Nishikawa, M; Okuhara, M | 1 |
| Blake, DR; Cruwys, SC; Kidd, BL; Mapp, PI; Walsh, DA | 1 |
| Mantione, CR; Rodriguez, R | 1 |
| Barnes, PJ; Chung, KF; Hui, KP; Lemen, RJ; Lötvall, JO | 1 |
| Ohkubo, T; Shibata, M; Takahashi, H | 1 |
| Brain, SD; Hughes, SR; Williams, TJ | 1 |
| Amico-Roxas, M; Caruso, A; Clementi, G; Cutuli, V; Fiore, CE; Prato, A | 1 |
| Brodda-Jansen, G; Hedqvist, P; Lundeberg, T; Raud, J; Theodorsson, E | 1 |
| Amann, R; Donnerer, J; Lembeck, F | 1 |
| Brain, SD; Williams, TJ | 2 |
| Inoki, R; Shibutani, T; Yonehara, N | 1 |
| Brodin, E; Dalsgaard, CJ; Haegerstrand, A; Jonsson, CE | 1 |
| Imai, Y; Inoki, R; Yonehara, N | 1 |
| Fujii, T; Morimoto, H; Senoh, H | 1 |
| Nieber, K; Oehme, P; Schreiber, J; Slapke, J | 1 |
| Imai, Y; Inoki, R; Shibutani, T; Yonehara, N | 1 |
| Van Cauwenberge, P | 1 |
5 review(s) available for substance p and Anasarca
| Article | Year |
|---|---|
H₂S and substance P in inflammation.
Topics: Acute Disease; Animals; Burns; Carrageenan; Ceruletide; Disease Models, Animal; Drug Synergism; Edema; Endotoxemia; Hydrogen Sulfide; Lipopolysaccharides; Lung Injury; Mice; Pancreatitis; Substance P | 2015 |
[The fibrositis syndrome (author's transl)].
Topics: Adult; Behavior Therapy; Chlorpromazine; Edema; Endorphins; Female; Fibromyalgia; Humans; Male; Middle Aged; Neurotic Disorders; Obesity; Pain; Pain Management; Sleep Wake Disorders; Substance P; Syndrome; Tryptophan | 1980 |
Capsaicin and sensory neurones--a review.
Topics: Animals; Axonal Transport; Axons; Capsaicin; Cholecystokinin; Edema; Fatty Acids, Unsaturated; Ganglia, Spinal; Nerve Degeneration; Nerve Fibers; Neurons, Afferent; Pain; Rats; Reflex; Sensation; Substance P | 1983 |
Neurokinin mediation of edema and inflammation.
Topics: Animals; Edema; Humans; Inflammation; Neurokinin A; Neurokinin B; Substance P; Tachykinins | 2000 |
[The role of substance P in regulating bronchomotor tone and the pathogenesis of bronchial hyperreactivity].
Topics: Animals; Asthma; Bronchi; Bronchial Diseases; Bronchitis; Edema; Humans; Substance P; Vasodilation | 1989 |
2 trial(s) available for substance p and Anasarca
| Article | Year |
|---|---|
Substance P-induced skin inflammation is not modulated by a single dose of sitagliptin in human volunteers.
Topics: Capsaicin; Carbonated Beverages; Cross-Over Studies; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Drug Eruptions; Edema; Erythema; Humans; Injections, Intradermal; Male; Pain; Pyrazines; Sitagliptin Phosphate; Skin; Substance P; Triazoles; Vasodilation | 2011 |
Intradermal actions of hypertonic saline involve neural and vascular mechanisms.
Topics: Anesthetics, Local; Double-Blind Method; Drug Interactions; Edema; Erythema; Forearm; Histamine; Humans; Injections, Intradermal; Lidocaine; Saline Solution, Hypertonic; Substance P | 1995 |
118 other study(ies) available for substance p and Anasarca
| Article | Year |
|---|---|
Synthesis and substance P antagonist activity of naphthimidazolium derivatives.
Topics: Animals; Binding, Competitive; Edema; Female; Guinea Pigs; Ileum; Imidazoles; Indoles; Male; Molecular Structure; Muscle Contraction; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Salivation; Structure-Activity Relationship; Substance P | 1992 |
Elucidating the Ability of CGRP to Modulate Microvascular Events in Mouse Skin.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Carrageenan; Edema; Inflammation; Mice; Mice, Knockout; Neuropeptides; Skin; Substance P; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2022 |
NF-κB Phosphorylation Inhibition Prevents Articular Cartilage Degradation in Osteoarthritis Rats via 2-Aminoquinoline.
Topics: Aminoquinolines; Animals; Cartilage, Articular; Cytokines; Dinoprostone; Edema; Extremities; Joints; Male; Matrix Metalloproteinase 13; NF-kappa B; Osteoarthritis; Phosphorylation; Rats, Wistar; Receptors, Purinergic P2X7; Signal Transduction; Substance P | 2020 |
Continuous infusion of substance P inhibits acute, but not subacute, inflammatory pain induced by complete Freund's adjuvant.
Topics: Acute Disease; Analgesics; Animals; Corpus Striatum; Edema; Freund's Adjuvant; Hyperalgesia; Inflammation; Infusions, Parenteral; Male; Pain; Pain Threshold; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P | 2020 |
The potential anti-inflammatory and anti-nociceptive effects of rat hemopressin (PVNFKFLSH) in experimental arthritis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Behavior, Animal; Cytokines; Edema; Gait; Hemoglobins; Inflammation; Injections, Intra-Articular; Knee Joint; Leukocytes; Male; Nociceptive Pain; Peptide Fragments; Rats, Sprague-Dawley; Receptors, Calcitonin Gene-Related Peptide; Substance P | 2021 |
Innervation Changes Induced by Inflammation in the Murine Vagina.
Topics: Animals; Calcitonin Gene-Related Peptide; Edema; Female; Freund's Adjuvant; Inflammation; Mice, Inbred C57BL; Neovascularization, Pathologic; Nerve Fibers; Substance P; Time Factors; Vagina; Vasoactive Intestinal Peptide | 2018 |
Role of tachykinin 1 and 4 gene-derived neuropeptides and the neurokinin 1 receptor in adjuvant-induced chronic arthritis of the mouse.
Topics: Animals; Arthritis, Experimental; Edema; Freund's Adjuvant; Gene Expression Regulation; Hyperalgesia; Inflammation; Interleukin-1beta; Joints; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Plethysmography; Protein Precursors; Receptors, Neurokinin-1; Signal Transduction; Substance P; Tachykinins; Tarsus, Animal | 2013 |
Substance P as a mediator of neurogenic inflammation after balloon compression induced spinal cord injury.
Topics: Animals; Aquaporin 4; Capillary Permeability; Cerebrospinal Fluid Pressure; Disease Models, Animal; Edema; Neurogenic Inflammation; Rabbits; Recovery of Function; Spinal Cord Injuries; Substance P | 2013 |
The selective PAC1 receptor agonist maxadilan inhibits neurogenic vasodilation and edema formation in the mouse skin.
Topics: Animals; Capillary Permeability; Disease Models, Animal; Ear; Edema; Female; Insect Proteins; Male; Mice; Microcirculation; Mustard Plant; Peroxidase; Plant Oils; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; Receptors, Vasoactive Intestinal Peptide, Type II; Receptors, Vasoactive Intestinal Polypeptide, Type I; Skin Physiological Phenomena; Substance P; Vasoactive Intestinal Peptide; Vasoconstrictor Agents; Vasodilation | 2014 |
Substance P protects against hyperoxic-induced lung injury in neonatal rats.
Topics: Animals; Animals, Newborn; Bronchopulmonary Dysplasia; Drug Evaluation, Preclinical; Edema; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Glutathione Peroxidase; Hyperoxia; Lung; Malondialdehyde; Neurotransmitter Agents; NF-E2-Related Factor 2; Pregnancy; Random Allocation; Rats, Sprague-Dawley; Substance P; Superoxide Dismutase | 2015 |
Substance P spinal signaling induces glial activation and nociceptive sensitization after fracture.
Topics: 2-Aminoadipic Acid; Animals; Anti-Inflammatory Agents; Complex Regional Pain Syndromes; Disease Models, Animal; Edema; Excitatory Amino Acid Antagonists; Hyperalgesia; Male; Minocycline; Neuroglia; Nociception; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord; Substance P; Tibial Fractures; Time Factors | 2015 |
Role of capsaicin-sensitive nerves and tachykinins in mast cell tryptase-induced inflammation of murine knees.
Topics: Animals; Arthritis; Calcitonin Gene-Related Peptide; Capsaicin; Cytokines; Edema; Hyperalgesia; Knee Joint; Male; Mice, Inbred C57BL; Mice, Knockout; Neurogenic Inflammation; Pain; Protein Precursors; Receptor, PAR-2; Receptors, Neurokinin-1; Substance P; Tachykinins; Touch; TRPV Cation Channels; Tryptases | 2016 |
Ketamine-xylazine anaesthesia and orofacial administration of substance P: A lethal combination in rats.
Topics: Anesthesia; Animals; Edema; Isoflurane; Ketamine; Male; Models, Animal; Piperidines; Quinuclidines; Rats, Wistar; Substance P; Xylazine | 2017 |
Increased pain and neurogenic inflammation in mice deficient of neutral endopeptidase.
Topics: Animals; Cold Temperature; Edema; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Hindlimb; Hot Temperature; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Neprilysin; Neurogenic Inflammation; Pain; Pain Measurement; Physical Stimulation; Sciatic Nerve; Skin; Skin Temperature; Substance P | 2009 |
Tumor bearing decreases systemic acute inflammation in rats--role of mast cell degranulation.
Topics: Animals; Bradykinin; Capillary Permeability; Capsaicin; Carrageenan; Cell Degranulation; Dextrans; Edema; Histamine; Inflammation; Mast Cells; Neoplasm Transplantation; Neoplasms; Neutrophil Activation; Neutrophil Infiltration; p-Methoxy-N-methylphenethylamine; Rats; Rats, Wistar; Serotonin; Substance P | 2009 |
Post-junctional facilitation of Substance P signaling in a tibia fracture rat model of complex regional pain syndrome type I.
Topics: Animals; Calcitonin Gene-Related Peptide; Cell Proliferation; Disease Models, Animal; Edema; Foot; Ganglia, Spinal; Gene Expression Regulation; Hyperemia; Inflammation; Keratinocytes; Male; Neprilysin; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Reflex Sympathetic Dystrophy; RNA, Messenger; Sciatic Nerve; Sensory Receptor Cells; Signal Transduction; Skin Temperature; Substance P; Tibial Fractures | 2009 |
The combination of neurokinin-1 and galanin receptor antagonists ameliorates caerulein-induced acute pancreatitis in mice.
Topics: Amylases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ceruletide; Edema; Galanin; Mice; Neurokinin-1 Receptor Antagonists; Pancreas; Pancreas, Exocrine; Pancreatitis; Peroxidase; Quinuclidines; Receptors, Galanin; Receptors, Neurokinin-1; Substance P | 2010 |
Anti-inflammatory evaluation of Coronopus didymus in the pleurisy and paw oedema models in mice.
Topics: Adenosine Deaminase; Animals; Anti-Inflammatory Agents; Bradykinin; Brazil; Carrageenan; Edema; Histamine; Inflammation; Leukocyte Count; Leukocytes; Mice; Neutrophils; Nitric Oxide; Peroxidase; Plant Leaves; Pleurisy; Rats; Substance P | 2010 |
Subcutaneous injection of endokinin C/D attenuates carrageenan-induced inflammation.
Topics: Analgesics, Non-Narcotic; Animals; Carrageenan; Dose-Response Relationship, Drug; Edema; Hindlimb; Hot Temperature; Humans; Hyperalgesia; Inflammation; Injections, Subcutaneous; Male; Neuritis; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Peripheral Nervous System Agents; Quinuclidines; Rats; Rats, Sprague-Dawley; Reaction Time; Substance P; Tachykinins | 2010 |
The vasoactive potential of kisspeptin-10 in the peripheral vasculature.
Topics: Animals; Blood Circulation; Dose-Response Relationship, Drug; Edema; Endothelin-1; Female; Gene Expression Regulation; Histamine Antagonists; Humans; Indomethacin; Kisspeptins; Male; Mice; Microvessels; Organ Specificity; Pallor; Receptors, Calcitonin Gene-Related Peptide; Receptors, G-Protein-Coupled; Receptors, Kisspeptin-1; RNA, Messenger; Substance P; Vasoconstriction; Vasoconstrictor Agents | 2011 |
Anti-inflammatory and anti-ulcer activities of carvacrol, a monoterpene present in the essential oil of oregano.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Arachidonic Acid; Cymenes; Edema; Female; Indomethacin; Inflammation; Male; Mice; Monoterpenes; Oils, Volatile; Origanum; Rats; Rats, Wistar; Ruthenium Red; Stomach Ulcer; Substance P; Tetradecanoylphorbol Acetate | 2012 |
Comparative study of the anti-edematogenic effects of anethole and estragole.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Anti-Inflammatory Agents; Bradykinin; Carrageenan; Edema; Histamine; Mice; Nitric Oxide; Serotonin; Substance P; Tumor Necrosis Factor-alpha | 2012 |
Comparison of perivascular and intramuscular applied botulinum toxin a pretreatment on muscle flap ischemia-reperfusion injury and chemical delay.
Topics: Animals; Biopsy; Botulinum Toxins, Type A; Calcitonin Gene-Related Peptide; Edema; Immunohistochemistry; Injections, Intramuscular; Ischemic Preconditioning; Lymphocyte Count; Muscle, Skeletal; Neovascularization, Physiologic; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Substance P; Surgical Flaps; Vascular Endothelial Growth Factor A | 2013 |
Pharmacological profile of (2R-trans)-4-[1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinyl]-N-(2,6-dimethylphenyl)-1-acetamide (S)-Hydroxybutanedioate (R116301), an orally and centrally active neurokinin-1 receptor antagonist.
Topics: Administration, Oral; Allergens; Animals; Butanols; Capsaicin; Cats; Dogs; Edema; Ferrets; Gerbillinae; Guinea Pigs; Histamine; Kinetics; Malates; Mice; Motor Activity; Neurokinin-1 Receptor Antagonists; Piperidines; Platelet Activating Factor; Rabbits; Receptors, Neurokinin-1; Salivation; Substance P; Time Factors | 2002 |
Neurokinin B induces oedema formation in mouse lung via tachykinin receptor-independent mechanisms.
Topics: Animals; Antipsychotic Agents; Benzamides; Cyclooxygenase Inhibitors; Edema; Enzyme Inhibitors; Extravascular Lung Water; Female; Indomethacin; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurokinin B; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Piperidines; Plasma; Pulmonary Edema; Receptors, Neurokinin-1; Substance P | 2002 |
Time course and substance P effects on the vascular and morphological changes in adjuvant-induced monoarthritic rats.
Topics: Animals; Arthritis, Experimental; Capillary Permeability; Drug Synergism; Edema; Evans Blue; Freund's Adjuvant; Knee Joint; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Substance P; Time Factors | 2004 |
Substance P signaling contributes to the vascular and nociceptive abnormalities observed in a tibial fracture rat model of complex regional pain syndrome type I.
Topics: Animals; Body Temperature; Bone Diseases, Metabolic; Casts, Surgical; Disease Models, Animal; Edema; Hindlimb; Indoles; Male; Nociceptors; Piperidines; Rats; Rats, Sprague-Dawley; Reflex Sympathetic Dystrophy; Signal Transduction; Substance P; Tibial Fractures | 2004 |
The contribution of autophosphorylated alpha-calcium-calmodulin kinase II to injury-induced persistent pain.
Topics: Animals; Behavior, Animal; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Count; Edema; Freund's Adjuvant; Ganglia, Spinal; Glycoproteins; Immunohistochemistry; Intermediate Filament Proteins; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nerve Tissue Proteins; Nociceptors; Oncogene Proteins v-fos; Pain; Pain Measurement; Pain Threshold; Peripherins; Phosphorylation; Physical Stimulation; Protein Kinase C; Reaction Time; Substance P; Time Factors; Trigeminal Ganglion; Wounds and Injuries | 2004 |
Substance P does not play a critical role in neurogenic inflammation in the rat masseter muscle.
Topics: Analgesics; Animals; Capsaicin; Disease Models, Animal; Edema; Inflammation Mediators; Male; Masseter Muscle; Mustard Plant; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Plant Extracts; Plant Oils; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P | 2005 |
[Effect of cetirizine hydrochloride on the expression of substance P in IgE-mediated triphasic cutaneous reaction].
Topics: Animals; Anti-Allergic Agents; Cetirizine; Dose-Response Relationship, Drug; Ear; Edema; Female; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Immunoglobulin E; Mice; Mice, Inbred BALB C; Passive Cutaneous Anaphylaxis; Substance P | 2005 |
Neurokinin-1 receptor in peripheral nerve terminals mediates thermal hyperalgesia.
Topics: Androstanes; Animals; Behavior, Animal; Benzimidazoles; Cell Degranulation; Edema; Hyperalgesia; Male; Mast Cells; Nerve Endings; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; p-Methoxy-N-methylphenethylamine; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Sural Nerve | 2006 |
[Study on the correlation of substance P in middle ear effusion and clinical presentation in secretory otitis media].
Topics: Adolescent; Adult; Aged; Child; Edema; Female; Humans; Male; Middle Aged; Otitis Media with Effusion; Substance P; Young Adult | 2005 |
12-Acetoxyhawtriwaic acid lactone, a diterpene from Egletes viscosa, attenuates capsaicin-induced ear edema and hindpaw nociception in mice: possible mechanisms.
Topics: Analgesics; Animals; Asteraceae; Capsaicin; Diterpenes; Diterpenes, Clerodane; Ear; Edema; Flowers; Glyburide; Hindlimb; Lactones; Male; Mice; Naloxone; Nociceptors; Substance P; Theophylline; TRPV Cation Channels | 2006 |
How important are NK1 receptors for influencing microvascular inflammation and itch in the skin? Studies using Phoneutria nigriventer venom.
Topics: Administration, Topical; Animals; Dose-Response Relationship, Drug; Edema; Female; Injections, Intradermal; Injections, Intravenous; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurokinin-1 Receptor Antagonists; Piperidines; Pruritus; Quinuclidines; Receptors, Neurokinin-1; Skin; Spider Venoms; Substance P; Vasculitis, Leukocytoclastic, Cutaneous | 2006 |
Anti-inflammatory effects of 4-phenyl-3-butenoic acid and 5-(acetylamino)-4-oxo-6-phenyl-2-hexenoic acid methyl ester, potential inhibitors of neuropeptide bioactivation.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Caproates; Cyclooxygenase 1; Cyclooxygenase 2; Dose-Response Relationship, Drug; Edema; Esters; Fatty Acids, Monounsaturated; Group II Phospholipases A2; Humans; In Vitro Techniques; Male; Molecular Structure; Neuropeptides; Phospholipases A; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Substance P | 2007 |
Contributions of histamine, prostanoids, and neurokinins to edema elicited by edema toxin from Bacillus anthracis.
Topics: Animals; Antigens, Bacterial; Aprepitant; Bacillus anthracis; Bacterial Toxins; Capillary Permeability; Celecoxib; Cell Degranulation; Cell Line; Disease Models, Animal; Edema; Enzyme Inhibitors; Histamine; Histamine H1 Antagonists; Humans; Indomethacin; Injections, Intradermal; Mast Cells; Morpholines; Neurokinin-1 Receptor Antagonists; Prostaglandin Antagonists; Prostaglandins; Pyrazoles; Pyrilamine; Rabbits; Substance P; Sulfonamides; Tachykinins | 2007 |
Mandatory role of proteinase-activated receptor 1 in experimental bladder inflammation.
Topics: Animals; Antigens; Cell Line; Cystitis; Edema; Granulocytes; Humans; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, PAR-1; Receptor, PAR-2; Receptors, Proteinase-Activated; Substance P; Urinary Bladder; Urothelium | 2007 |
Bradykinin- and substance P-induced edema formation in the hamster cheek pouch is tyrosine kinase dependent.
Topics: Animals; Bradykinin; Capillary Permeability; Cheek; Cricetinae; Dextrans; Disease Models, Animal; Edema; Fluorescein-5-isothiocyanate; Genistein; Male; Mesocricetus; Microcirculation; Microscopy, Video; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Signal Transduction; Substance P; Tyrphostins | 2007 |
Effects of the bisphosphonate ibandronate on hyperalgesia, substance P, and cytokine levels in a rat model of persistent inflammatory pain.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Cytokines; Dinoprostone; Diphosphonates; Drug Evaluation, Preclinical; Edema; Foot; Freund's Adjuvant; Ganglia, Spinal; Hyperalgesia; Ibandronic Acid; Inflammation; Interleukin-1beta; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance P; Tumor Necrosis Factor-alpha | 2008 |
Continuous intra-arterial application of substance P induces signs and symptoms of experimental complex regional pain syndrome (CRPS) such as edema, inflammation and mechanical pain but no thermal pain.
Topics: Animals; Chemotaxis, Leukocyte; Complex Regional Pain Syndromes; Disease Models, Animal; Edema; Endothelial Cells; Hyperalgesia; Hypesthesia; Infusion Pumps, Implantable; Injections, Intra-Arterial; Male; Microcirculation; Neurogenic Inflammation; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Substance P | 2007 |
Roles of TRPV1 and neuropeptidergic receptors in dorsal root reflex-mediated neurogenic inflammation induced by intradermal injection of capsaicin.
Topics: Analgesics; Animals; Bicuculline; Calcitonin Gene-Related Peptide; Capsaicin; Edema; GABA Antagonists; Injections, Intradermal; Neurogenic Inflammation; Peptide Fragments; Rats; Receptors, Neurokinin-1; Reflex; Spinal Nerve Roots; Substance P; TRPV Cation Channels; Vasodilation | 2007 |
Neurogenic extravasation and substance P levels are low in muscle as compared to skin the rat hindlimb.
Topics: Animals; Capillary Permeability; Edema; Evans Blue; Inflammation; Muscles; Peripheral Nerves; Rats; Skin; Substance P | 1984 |
The mechanism of enhancement of the neurogenic oedema response by baclofen.
Topics: Animals; Baclofen; Blood Pressure; Drug Interactions; Edema; Exudates and Transudates; Injections, Intravenous; Injections, Subcutaneous; Male; Neurons; Rats; Serotonin; Substance P | 1980 |
Indirect evidence for the importance of axonal transport in maintenance of stores of the mediator of neurogenic oedema.
Topics: Animals; Axonal Transport; Colchicine; Edema; Electric Stimulation; Leg; Male; Rats; Substance P; Time Factors | 1980 |
Inflammatory peptide in spinal cord: evidence that the mediator of antidromic vasodilatation is not substance P.
Topics: Afferent Pathways; Animals; Animals, Newborn; Biological Assay; Capsaicin; Cattle; Edema; Guinea Pigs; Ileum; Peptides; Rats; Spinal Cord; Substance P; Vasodilation | 1980 |
Cigarette smoke-induced airway oedema due to activation of capsaicin-sensitive vagal afferents and substance P release.
Topics: Afferent Pathways; Animals; Capillary Permeability; Capsaicin; Edema; Male; Microscopy, Fluorescence; Rats; Rats, Inbred Strains; Respiratory System; Respiratory Tract Diseases; Smoking; Substance P; Synaptic Transmission; Vagus Nerve | 1983 |
A substance P antagonist inhibits heat-induced oedema in the rat skin.
Topics: Animals; Cimetidine; Edema; Electric Stimulation; Hot Temperature; Male; Nerve Fibers; Peptide Fragments; Pyrilamine; Rats; Skin; Substance P | 1984 |
Substance P in sensory nerve fibres contributes to the development of oedema in the rat hind paw after thermal injury.
Topics: Animals; Blood Proteins; Burns; Capsaicin; Edema; Evans Blue; Female; Hindlimb; Male; Nerve Tissue Proteins; Neurons, Afferent; Rats; Rats, Inbred Strains; Substance P; Temperature; Time Factors | 1984 |
Inhibition of cigarette smoke-induced oedema in the nasal mucosa by capsaicin pretreatment and a substance P antagonist.
Topics: Animals; Blood Pressure; Capillary Permeability; Capsaicin; Carbon Monoxide; Edema; Histamine Antagonists; Male; Nasal Mucosa; Nicotine; Rats; Rats, Inbred Strains; Smoking; Substance P | 1984 |
Profile of capsaicin-induced mouse ear oedema as neurogenic inflammatory model: comparison with arachidonic acid-induced ear oedema.
Topics: Administration, Cutaneous; Animals; Arachidonic Acid; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cyproheptadine; Edema; Indomethacin; Male; Mice; Neuropeptides; Nifedipine; Substance P | 1993 |
Anti-edema action of formoterol in rat trachea does not depend on capsaicin-sensitive sensory nerves.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Afferent Pathways; Animals; Bradykinin; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Edema; Endothelium, Vascular; Ethanolamines; Formoterol Fumarate; Injections, Intravenous; Male; Platelet Activating Factor; Premedication; Rats; Rats, Inbred F344; Substance P; Trachea; Tracheal Diseases | 1994 |
Time-dependent changes in Bolton-Hunter-labeled 125I-substance P binding in rat spinal cord following unilateral adjuvant-induced peripheral inflammation.
Topics: Animals; Arthritis, Experimental; Autoradiography; Edema; Inflammation; Iodine Radioisotopes; Kinetics; Male; Neurons, Afferent; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Succinimides; Synapses; Synaptic Transmission | 1993 |
Modulation of carrageenan-induced hind paw edema by substance P.
Topics: Animals; Capsaicin; Carrageenan; Dose-Response Relationship, Drug; Drug Synergism; Edema; Female; Foot; Organ Size; Rats; Rats, Sprague-Dawley; Substance P | 1994 |
Effect of a neurokinin-1 (NK1) receptor antagonist on oedema formation induced by tachykinins, carrageenin and an allergic response in guinea-pig skin.
Topics: Animals; Bradykinin; Calcitonin Gene-Related Peptide; Carrageenan; Edema; Guinea Pigs; Indoles; Inflammation; Injections, Intradermal; Isoindoles; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Pyrilamine; Skin; Substance P; Tachykinins | 1994 |
Inhibition of hind-paw edema and cutaneous vascular plasma extravasation in mice by acetylshikonin.
Topics: Adrenalectomy; Animals; Anthraquinones; Bradykinin; Capillary Permeability; Cell Degranulation; Dexamethasone; Diphenhydramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drugs, Chinese Herbal; Edema; Glucuronidase; Glycogen; Hindlimb; Histamine; Indomethacin; Liver; Mast Cells; Methysergide; Mice; p-Methoxy-N-methylphenethylamine; Polymyxin B; Substance P | 1995 |
An investigation into the mechanism of capsaicin-induced oedema in rabbit skin.
Topics: Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Bradykinin; Calcitonin Gene-Related Peptide; Capillary Permeability; Capsaicin; Catalase; Dexamethasone; Drug Interactions; Edema; Histamine; Indoles; Indomethacin; Injections, Intradermal; Injections, Intravenous; Isoindoles; Male; Piperidines; Rabbits; Regional Blood Flow; Ruthenium Red; Skin; Substance P; Vasodilator Agents | 1995 |
Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators.
Topics: Animals; Antibodies, Monoclonal; Biphenyl Compounds; Chlorpheniramine; Dihydropyridines; Dose-Response Relationship, Drug; Edema; Female; Guinea Pigs; Imidazoles; Indoles; Inflammation; Isoindoles; Neurokinin-1 Receptor Antagonists; Pyrans; Quinolones; Skin; Substance P; Time Factors | 1995 |
Calcitonin gene-related peptide, substance P and nitric oxide are involved in cutaneous inflammation following ultraviolet irradiation.
Topics: Animals; Arginine; Biphenyl Compounds; Calcitonin Gene-Related Peptide; Dermatitis; Edema; Hypnotics and Sedatives; Immunohistochemistry; Male; Miotics; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peptide Fragments; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Skin; Substance P; Ultrasonography; Ultraviolet Rays | 1995 |
Involvement of substance P in ultraviolet irradiation-induced inflammation in rat skin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Dermatitis; Edema; Erythema; Hindlimb; Immunohistochemistry; Male; Nerve Fibers; Radiation Injuries, Experimental; Rats; Rats, Sprague-Dawley; Substance P; Ultraviolet Rays | 1995 |
Inhibition by actinomycin D of neurogenic mouse ear oedema.
Topics: Animals; Bradykinin; Calcimycin; Calcitonin Gene-Related Peptide; Capsaicin; Cycloheximide; Dactinomycin; Disease Models, Animal; Dose-Response Relationship, Drug; Doxorubicin; Ear Diseases; Edema; Histamine; Injections, Intravenous; Leukotriene C4; Male; Mast Cells; Mice; p-Methoxy-N-methylphenethylamine; Platelet Activating Factor; Rats; Rats, Wistar; Serotonin; Substance P; Tachykinins; Vasoactive Intestinal Peptide | 1995 |
Substance P-induced fibrinolysis in the forearm of healthy humans.
Topics: Adult; Edema; Fibrinolysis; Forearm; Humans; Infusions, Intra-Arterial; Male; Substance P | 1993 |
The modulation of inflammatory oedema by calcitonin gene-related peptide.
Topics: Alprostadil; Animals; Calcitonin Gene-Related Peptide; Capillary Permeability; Carrageenan; Edema; Foot; Histamine; Iodine Radioisotopes; Male; Mice; Rats; Rats, Sprague-Dawley; Rats, Wistar; Serotonin; Substance P | 1993 |
A new NK1 receptor antagonist (CP-99,994) prevents the increase in tracheal vascular permeability produced by hypertonic saline.
Topics: Animals; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Edema; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Hypertonic Solutions; Neurokinin A; Neurons, Afferent; Piperidines; Platelet Activating Factor; Rats; Rats, Inbred F344; Receptors, Neurotransmitter; Receptors, Tachykinin; Sodium Chloride; Stimulation, Chemical; Substance P; Trachea; Tracheal Diseases | 1993 |
The pharmacological properties of FK888, a novel dipeptide NK1 antagonist.
Topics: Animals; Bronchoconstriction; Capsaicin; Cell Membrane; Dipeptides; Edema; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Indoles; Kinetics; Lung; Muscle Contraction; Muscle, Smooth; Neurokinin A; Receptors, Neurokinin-1; Substance P | 1993 |
Non-specific activity of (+/-)CP-96,345 in models of pain and inflammation.
Topics: Animals; Biphenyl Compounds; Carrageenan; Dose-Response Relationship, Drug; Edema; Hyperalgesia; Hypnotics and Sedatives; Inflammation; Neurokinin-1 Receptor Antagonists; Pain; Rats; Stereoisomerism; Substance P; Time Factors; Verapamil | 1993 |
Demonstration of a 'septide-sensitive' inflammatory response in rat skin.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Proteins; Capillary Permeability; Dermatitis, Contact; Dose-Response Relationship, Drug; Edema; Indoles; Isoindoles; Male; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Nitric Oxide Synthase; p-Methoxy-N-methylphenethylamine; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1995 |
Effects of chlomipramine and fluoxetine on subcutaneous carrageenin-induced inflammation in the rat.
Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Carrageenan; Clomipramine; Dinoprostone; Dose-Response Relationship, Drug; Edema; Fluoxetine; Male; Rats; Rats, Sprague-Dawley; Substance P | 1995 |
Involvement of substance P as a mediator in capsaicin-induced mouse ear oedema.
Topics: Animals; Capillary Permeability; Capsaicin; Ear Diseases; Edema; Male; Mice; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tachyphylaxis | 1995 |
The effect of a tachykinin NK1 receptor antagonist, SR140333, on oedema formation induced in rat skin by venom from the Phoneutria nigriventer spider.
Topics: Animals; Edema; Male; Methysergide; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrilamine; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Skin Diseases; Spider Venoms; Substance P | 1996 |
Expression of mRNAs for preprotachykinin and nerve growth factor receptors in the dorsal root-ganglion following peripheral inflammation.
Topics: Animals; Edema; Foot; Freund's Adjuvant; Ganglia, Spinal; In Situ Hybridization; Male; Neurons; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptor, Nerve Growth Factor; Receptors, Nerve Growth Factor; RNA Probes; RNA, Messenger; Substance P; Tachykinins | 1996 |
N-(2-hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation.
Topics: Amides; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Degranulation; Dextrans; Ear, External; Edema; Endocannabinoids; Ethanolamines; Evans Blue; Excipients; Extravasation of Diagnostic and Therapeutic Materials; Female; Formaldehyde; Hyperalgesia; Male; Mast Cells; Mice; Mice, Inbred BALB C; Palmitic Acids; Passive Cutaneous Anaphylaxis; Rats; Rats, Wistar; Substance P | 1996 |
Intraplantar injection of nerve growth factor into the rat hind paw: local edema and effects on thermal nociceptive threshold.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cyclooxygenase Inhibitors; Denervation; Edema; Foot; Histamine; Injections; Male; Mast Cells; Nerve Growth Factors; Neurons, Afferent; Pain Threshold; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Substance P | 1996 |
Carbamazepine exerts anti-inflammatory effects in the rat.
Topics: Animals; Anti-Inflammatory Agents; Carbamazepine; Dinoprostone; Dose-Response Relationship, Drug; Edema; Exudates and Transudates; Hyperalgesia; Inflammation; Male; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Reaction Time; Substance P | 1995 |
Effect of the tachykinin receptor antagonists, SR 140333, FK 888, and SR 142801, on capsaicin-induced mouse ear oedema.
Topics: Animals; Binding Sites; Capsaicin; Dipeptides; Disease Models, Animal; Ear Diseases; Edema; Indoles; Injections, Intravenous; Lethal Dose 50; Male; Mice; Piperidines; Quinuclidines; Receptors, Tachykinin; Skin; Stereoisomerism; Structure-Activity Relationship; Substance P | 1996 |
Effect of SR 140333, a selective NK1 antagonist, on antigen-induced oedema formation in rat skin.
Topics: Allergens; Animals; Edema; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Skin Diseases; Substance P | 1996 |
Lymphatic microcirculation.
Topics: Animals; Calcium; Cattle; Diastole; Edema; Inflammation; Lymphatic System; Reactive Oxygen Species; Stroke Volume; Substance P; Systole | 1996 |
Involvement of tachykinin receptors in oedema formation and plasma extravasation induced by substance P, neurokinin A, and neurokinin B in mouse ear.
Topics: Animals; Capillary Permeability; Edema; Glycopeptides; Male; Mice; Neurokinin A; Neurokinin B; Piperidines; Quinuclidines; Receptors, Tachykinin; Substance P | 1996 |
Participation of serotonin in capsaicin-induced mouse ear edema.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Capsaicin; Ear Diseases; Edema; Male; Mice; Mice, Inbred Strains; Serotonin; Substance P | 1995 |
Involvement of sensory neuropeptides in the development of plasma extravasation in rat dorsal skin following thermal injury.
Topics: Animals; Burns; Calcitonin Gene-Related Peptide; Edema; Male; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Skin; Substance P | 1996 |
Inhibitory effect of glycyrrhetinic acid derivatives on capsaicin-induced ear edema in mice.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Capsaicin; Dose-Response Relationship, Drug; Edema; Glycyrrhetinic Acid; Linear Models; Male; Mice; Mice, Inbred Strains; Substance P | 1996 |
Influence of several peptidase inhibitors on the pro-inflammatory effects of substance P, capsaicin and collagenase.
Topics: Albumins; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Capillary Permeability; Capsaicin; Captopril; Collagenases; Dose-Response Relationship, Drug; Edema; Glycopeptides; Hindlimb; Indoles; Inflammation; Isoindoles; Male; Matrix Metalloproteinase Inhibitors; Methysergide; Neurokinin-1 Receptor Antagonists; Oligopeptides; Organ Size; Protease Inhibitors; Rats; Rats, Wistar; Serotonin Antagonists; Substance P | 1996 |
Inhibition of hind-paw edema and cutaneous vascular plasma extravasation by 2-chloro-3-methoxycarbonylpropionamido-1,4-naphthoquinone (PP1D1) in mice.
Topics: Animals; Anti-Inflammatory Agents; Bradykinin; Capillary Permeability; Edema; Mice; Mice, Inbred ICR; Naphthoquinones; Passive Cutaneous Anaphylaxis; Serotonin; Substance P | 1996 |
Antiinflammatory and analgesic activity of an inhibitor of neuropeptide amidation.
Topics: Amidine-Lyases; Amino Acid Sequence; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Carrageenan; Edema; Fatty Acids, Monounsaturated; Inflammation; Kinetics; Lyases; Male; Mice; Mixed Function Oxygenases; Multienzyme Complexes; Rats; Rats, Sprague-Dawley; Serotonin; Substance P; Substrate Specificity | 1997 |
Central modulation of Brewer's yeast-induced peripheral inflammation by neuropeptides bradykinin and substance P.
Topics: Analgesics; Animals; Bradykinin; Edema; Inflammation; Male; Pain; Rats; Rats, Sprague-Dawley; Saccharomyces cerevisiae; Substance P | 1996 |
Involvement of 5-hydroxytryptamine and bradykinin in the hyperalgesia induced in rats by collagenase from Clostridium histolyticum.
Topics: Analgesics; Angiotensin-Converting Enzyme Inhibitors; Animals; Behavior, Animal; Bradykinin; Clostridium; Edema; Female; Hindlimb; Hyperalgesia; Indoles; Isoindoles; Kininogens; Lisinopril; Methysergide; Microbial Collagenase; Neurokinin-1 Receptor Antagonists; Ondansetron; Prostaglandins; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Substance P | 1997 |
Mast cell involvement in the rat paw oedema response to 1,8-cineole, the main constituent of eucalyptus and rosemary oils.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cell Degranulation; Cyclohexanols; Dexamethasone; Edema; Eucalyptol; Eucalyptus; Histamine Release; Indomethacin; Male; Mast Cells; Menthol; Monoterpenes; Oils, Volatile; p-Methoxy-N-methylphenethylamine; Plants, Medicinal; Rats; Rats, Wistar; Serotonin; Substance P; Terpenes; Time Factors | 1997 |
Activity of tachykinin NK1 and bradykinin B2 receptor antagonists, and an opioid ligand at different stimulation parameters in neurogenic inflammation in the rat.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Edema; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Extravasation of Diagnostic and Therapeutic Materials; Male; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptor, Bradykinin B2; Receptors, Neurokinin-1; Receptors, Opioid, mu; Substance P; Time Factors | 1998 |
Lack of evidence for tachykinin NK1 receptor-mediated neutrophil accumulation in the rat cutaneous microvasculature by thermal injury.
Topics: Abdomen; Animals; Bradykinin; Burns; Dose-Response Relationship, Drug; Edema; Hindlimb; Histamine; Inflammation; Interleukin-1; Male; Microcirculation; Mustard Plant; Neurokinin-1 Receptor Antagonists; Neutrophils; Peptide Fragments; Piperidines; Plant Extracts; Plant Oils; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Skin; Substance P; Time Factors | 1999 |
Inhibitory effects of tachykinin receptor antagonists on thermally induced inflammatory reactions in a rat model.
Topics: Animals; Burns; Disease Models, Animal; Edema; Follow-Up Studies; Inflammation; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Skin Diseases; Substance P | 1999 |
Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.
Topics: Animals; Anti-Inflammatory Agents; Axotomy; Dose-Response Relationship, Drug; Edema; Evans Blue; Glucocorticoids; Hindlimb; Hyperalgesia; Male; Methylprednisolone; Neurogenic Inflammation; Nociceptors; Pain Threshold; Rats; Rats, Sprague-Dawley; Reflex; Sciatic Nerve; Substance P | 1999 |
Use of NK(1) knockout mice to analyze substance P-induced edema formation.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Edema; Female; Histamine H1 Antagonists; Injections, Intradermal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; p-Methoxy-N-methylphenethylamine; Pyrilamine; Receptors, Neurokinin-1; Skin Diseases; Substance P; Tachykinins | 1999 |
Calcitonin gene-related peptide and substance P immunoreactivity in rat trigeminal ganglia and brainstem following adjuvant-induced inflammation of the temporomandibular joint.
Topics: Afferent Pathways; Animals; Arthritis, Experimental; Brain Stem; Calcitonin Gene-Related Peptide; Cartilage, Articular; Edema; Freund's Adjuvant; Male; Pharmaceutical Vehicles; Rats; Rats, Sprague-Dawley; Substance P; Temporomandibular Joint; Temporomandibular Joint Disc; Temporomandibular Joint Disorders; Time Factors; Trigeminal Ganglion; Trigeminal Nuclei | 2000 |
Substance P mediates inflammatory oedema in acute pancreatitis via activation of the neurokinin-1 receptor in rats and mice.
Topics: Acute Disease; Amylases; Animals; Blood Pressure; Ceruletide; Edema; Gastrointestinal Agents; Inflammation; Male; Mice; Neurokinin-1 Receptor Antagonists; Pancreatitis; Peroxidase; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P | 2000 |
Evaluation of anti-scratch properties of oxatomide and epinastine in mice.
Topics: Animals; Anti-Allergic Agents; Antipruritics; Capillary Permeability; Dibenzazepines; Dinitrofluorobenzene; Edema; Female; Histamine; Histamine H1 Antagonists; Imidazoles; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Passive Cutaneous Anaphylaxis; Piperazines; Substance P | 2000 |
Changes in paw oedema triggered via bradykinin B(1) and B(2) receptors in streptozotocin-diabetic rats.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Diabetes Mellitus, Experimental; Dinoprostone; Edema; Hindlimb; Hypoglycemic Agents; Insulin, Long-Acting; Male; Rats; Rats, Wistar; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin; Substance P; Time Factors | 2001 |
Lack of a significant effect of deletion of the tachykinin neurokinin-1 receptor on wound healing in mouse skin.
Topics: Animals; Capsaicin; Edema; Gene Deletion; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Neurokinin-1; Skin; Substance P; Sutures; Wound Healing | 2001 |
Modulation of inflammatory paw oedema by cysteamine in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Celecoxib; Corticotropin-Releasing Hormone; Cystamine; Edema; Formaldehyde; Histamine; Indomethacin; Pyrazoles; Rats; Somatostatin; Substance P; Sulfonamides; Tumor Necrosis Factor-alpha | 2002 |
Substance P provokes cutaneous erythema and edema through a histamine-independent pathway.
Topics: Adult; Capsaicin; Edema; Erythema; Female; Histamine; Humans; Hydroxyzine; Male; Middle Aged; p-Methoxy-N-methylphenethylamine; Substance P | 1992 |
Effects of FK224, a novel compound NK1 and NK2 receptor antagonist, on airway constriction and airway edema induced by neurokinins and sensory nerve stimulation in guinea pigs.
Topics: Animals; Bronchoconstriction; Capsaicin; Constriction, Pathologic; Edema; Guinea Pigs; Histamine Antagonists; Injections, Intravenous; Male; Peptides, Cyclic; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Trachea | 1992 |
Enhanced release of immunoreactive CGRP and substance P from spinal dorsal horn slices occurs during carrageenan inflammation.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Carrageenan; Edema; In Vitro Techniques; Inflammation; Male; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1992 |
Calcitonin gene-related peptide increases blood flow and potentiates plasma protein extravasation in the rat knee joint.
Topics: Alprostadil; Animals; Blood Proteins; Calcitonin Gene-Related Peptide; Edema; Injections, Intra-Articular; Knee Joint; Male; Rats; Rats, Inbred Strains; Regional Blood Flow; Substance P; Synovial Membrane; Xenon Radioisotopes | 1992 |
WS9326A, a novel tachykinin antagonist isolated from Streptomyces violaceusniger no. 9326. II. Biological and pharmacological properties of WS9326A and tetrahydro-WS9326A (FK224)
Topics: Animals; Dose-Response Relationship, Drug; Edema; Guinea Pigs; In Vitro Techniques; Injections, Intravenous; Lactones; Male; Muscle Contraction; Peptides, Cyclic; Streptomyces; Substance P; Tachykinins; Trachea | 1992 |
The effects of calcitonin gene-related peptide on formation of intra-articular oedema by inflammatory mediators.
Topics: Animals; Bradykinin; Calcitonin Gene-Related Peptide; Capillary Permeability; Dose-Response Relationship, Drug; Edema; Histamine; Joint Diseases; Male; Rats; Rats, Wistar; Substance P | 1992 |
A bradykinin (BK)1 receptor antagonist blocks capsaicin-induced ear inflammation in mice.
Topics: Animals; Bradykinin; Capsaicin; Ear, External; Edema; Inflammation; Male; Mice; Receptors, Bradykinin; Receptors, Neurotransmitter; Substance P | 1990 |
Airflow obstruction after substance P aerosol: contribution of airway and pulmonary edema.
Topics: Aerosols; Airway Obstruction; Airway Resistance; Animals; Body Weight; Edema; Evans Blue; Guinea Pigs; Lung Compliance; Male; Methacholine Compounds; Microcirculation; Muscle Contraction; Muscle, Smooth; Pulmonary Edema; Respiratory System; Substance P | 1990 |
[Participation of the sensory nerves in the inflammatory response induced by irritants].
Topics: Animals; Capillary Permeability; Capsaicin; Carnitine; Denervation; Edema; Irritants; Male; Mice; Neurons, Afferent; Rats; Rats, Inbred Strains; Sciatic Nerve; Substance P | 1990 |
Evidence that endogenous nitric oxide modulates oedema formation induced by substance P.
Topics: Animals; Arginine; Edema; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Rats; Rats, Inbred Strains; Regional Blood Flow; Skin; Stereoisomerism; Substance P | 1990 |
Parathyroid hormone fragment 1-34 inhibits drug-induced inflammation in various experimental models.
Topics: Acetates; Acetic Acid; Animals; Carrageenan; Edema; Inflammation; Male; Nystatin; Parathyroid Hormone; Peptide Fragments; Peritonitis; Rats; Rats, Inbred Strains; Serotonin; Substance P; Teriparatide | 1991 |
Potent anti-inflammatory action of calcitonin gene-related peptide.
Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Capsaicin; Cricetinae; Edema; Female; Histamine; Humans; Inflammation; Leukotriene B4; Male; Middle Aged; Mouth Mucosa; Rats; Serotonin; Skin; Skin Physiological Phenomena; Substance P | 1991 |
Neurogenic and non-neurogenic inflammation in the rat paw following chemical sympathectomy.
Topics: Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Carrageenan; Edema; Foot; Guanethidine; Inflammation; Mustard Plant; Norepinephrine; Oxidopamine; Plant Extracts; Plant Oils; Rats; Rats, Inbred Strains; Skin; Substance P; Sympathectomy, Chemical | 1991 |
Inflammatory oedema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular permeability.
Topics: Animals; Bradykinin; Calcitonin Gene-Related Peptide; Capillary Permeability; Complement C5; Complement C5a, des-Arginine; Dinoprostone; Drug Synergism; Edema; Histamine; Inflammation; Injections, Intradermal; Leukotriene B4; Male; N-Formylmethionine Leucyl-Phenylalanine; Nerve Tissue Proteins; Platelet Activating Factor; Prostaglandins E; Rabbits; Rats; Rats, Inbred Lew; Skin; Species Specificity; Substance P | 1985 |
Contribution of substance P to heat-induced edema in rat paw.
Topics: Animals; Bradykinin; Capsaicin; Denervation; Edema; Histamine; Hot Temperature; Male; Pyridazines; Rats; Rats, Inbred Strains; Substance P | 1987 |
Sensory neuropeptides contribute to oedema formation in experimental burns.
Topics: Animals; Burns; Dogs; Edema; Rats; Substance P | 1987 |
Effects of opioids on the heat stimulus-evoked substance P release and thermal edema in the rat hind paw.
Topics: Animals; Edema; Foot; Hot Temperature; Injections, Intra-Arterial; Male; Narcotics; Perfusion; Rats; Rats, Inbred Strains; Substance P | 1988 |
Interactions between the tachykinins and calcitonin gene-related peptide lead to the modulation of oedema formation and blood flow in rat skin.
Topics: Animals; Calcitonin Gene-Related Peptide; Drug Interactions; Edema; Histamine Antagonists; Male; Neurokinin A; Neurokinin B; Neuropeptides; Rats; Rats, Inbred Strains; Regional Blood Flow; Rheology; Serotonin Antagonists; Skin; Substance P; Tachykinins | 1989 |
Plasma extravasation by chemical mediators in rat skin and trachea: a role of neurogenic agents on tracheal edema formation.
Topics: Animals; Capsaicin; Carbachol; Edema; Histamine; Male; Neurons, Afferent; Platelet Activating Factor; Rats; Rats, Inbred Strains; Skin; Skin Physiological Phenomena; SRS-A; Substance P; Trachea | 1989 |
Participation of substance P in inflammatory responses.
Topics: Animals; Capsaicin; Dactinomycin; Denervation; Dexamethasone; Edema; Hot Temperature; Inflammation; Male; Rats; Rats, Inbred Strains; Sciatic Nerve; Spinal Nerves; Substance P | 1989 |
[Animal experiment concerning the relationship between tubal function and nasal resistance].
Topics: Airway Resistance; Animals; Edema; Eustachian Tube; Histamine; Macaca mulatta; Manometry; Nose; Otitis Media with Effusion; Substance P | 1989 |