substance p has been researched along with Adjuvant Arthritis in 83 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 9 (10.84) | 18.7374 |
1990's | 47 (56.63) | 18.2507 |
2000's | 14 (16.87) | 29.6817 |
2010's | 11 (13.25) | 24.3611 |
2020's | 2 (2.41) | 2.80 |
Authors | Studies |
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Achuthan, A; Anderson, GP; Cook, A; Ellson, C; Feeney, M; Fleetwood, AJ; Hamilton, JA; Jarnicki, A; Lee, KM; Modis, LK; Smith, JE | 1 |
Camargo, LL; Cerqueira, ARA; Costa, SKP; Denadai-Souza, A; Fernandes, ES; Ferro, ES; Gewehr, MCF; Lima, C; Muscará, MN; Schenka, AA; Teixeira, SA; Yshii, LM | 1 |
Berger, A; Borbély, E; Hajna, Z; Helyes, Z; Kereskai, L; Nagy, P; Paige, C; Pintér, E; Quinn, J; Sándor, K; Stewart, J; Szolcsányi, J; Tóth, I; Zimmer, A | 1 |
Ahmed, AS; Ahmed, M; Bakalkin, G; Gu, HF; Harris, HE; Li, J; Stark, A | 1 |
Chen, W; Lu, ZH; Wei, DM; Zhang, XD | 1 |
Balla, K; Bendele, A; Bogseth, R; Gass, J; Graham, S; Hutchcraft, A; Rabinow, B; Valaitis, P; Werling, J | 1 |
Hong, HS; Son, Y | 1 |
Dai, GH; Deng, WT; Guo, XD; Huang, KB; Luo, GQ; Pan, SY; Peng, KR; Qian, NS; Wu, XN; Xiang, W; Yang, HJ; Zhang, T | 1 |
Abdalla, HB; Barbosa, CM; Canales, GT; Clemente-Napimoga, JT; Lora, VR; Macedo, CG | 1 |
Averill, S; Cafferty, WB; Hunt, SP; Inglis, JJ; Kidd, BL; King, VR; Priestley, JV; Shortland, PJ; Thompson, SW | 1 |
Lam, FF; Ng, ES | 1 |
Chen, Y; Han, JE; Valtschanoff, JG; Willcockson, HH | 1 |
Ahmed, AS; Ahmed, M; Bakalkin, G; Hua, L; Li, J; Ossipov, MH; Stark, A; Yakovleva, T | 1 |
Ahmed, AS; Ahmed, M; Bakalkin, G; Erlandsson-Harris, H; Li, J; Stark, A | 1 |
Liu, HX | 1 |
Lam, FF; Ng, ES; Wong, HH | 1 |
Blades, M; Brain, SD; Castro da Rocha, FA; Keeble, J; Pitzalis, C | 1 |
Ackermann, PW; Bring, DK; Heidgren, ML; Kreicbergs, A | 1 |
McDougall, JJ; Zhang, C | 1 |
Bauer, JD; Cutler, SJ; Foster, MS; May, SW; Ogonowski, AA; Pollock, SH; Sunman, JA; Thompson, JR | 1 |
Colpaert, FC; Donnerer, J; Lembeck, F | 1 |
Bervoets, K; Colpaert, FC | 1 |
Chowdrey, HS; Harbuz, MS; Jessop, DS; Larsen, PJ; Lightman, SL | 1 |
Ahmed, M; Kreicbergs, A; Schultzberg, M; Srinivasan, GR; Theodorsson, E | 1 |
Galeazza, MT; Seybold, VS; Stucky, CL | 1 |
Sluka, KA; Westlund, KN | 1 |
Ahmed, M; Bjurholm, A; Kreicbergs, A; Srinivasan, GR; Theodorsson, E | 1 |
Kar, S; Quirion, R; Rees, RG | 1 |
Ferrell, WR; Karimian, SM; McDougall, JJ | 2 |
Besson, JM; Calvino, B; Couraud, JY | 1 |
Bowery, NG; Malcangio, M | 1 |
Ahmed, M; Bjurholm, A; Kreicbergs, A; Lundeberg, T; Schultzberg, M; Srinivasan, GR; Theodorsson, E | 1 |
Ahmed, M; Bjurholm, A; Kreicbergs, A; Schultzberg, M; Theodorsson, E | 1 |
Cruwys, SC; Garrett, NE; Kidd, BL; Tomlinson, DR | 2 |
Homonko, DA; Marshall, KW; Theriault, E | 2 |
Bakker, WH; Breeman, WA; Hazenberg, MP; Koper, JW; Krenning, EP; Kwekkeboom, DJ; Lamberts, SW; Setyono-Han, B; van der Pluijm, ME; VanHagen, MP; Visser, TJ; Visser-Wisselaar, HA | 1 |
Blackwell, JM; Chowdrey, HS; Harbuz, MS; Jessop, DS; Larsen, PJ; Lightman, SL | 1 |
Gur Aryeh, I; Niv, D | 1 |
Bileviciute, I; Lundeberg, T; Theodorsson, E | 1 |
Bilgiçyildirim, A; Funk, RH; Schwab, W | 1 |
Alstergren, P; Appelgren, A; Appelgren, B; Carleson, J; Kopp, S; Lundeberg, T; Srinivasan, GR; Theodorsson, E | 1 |
Hukuda, S; Imai, S; Konttinen, YT; Maeda, T; Santavirta, S; Tokunaga, Y | 1 |
Chen, J; Ji, H; Li, S; Liu, Y; Wu, S | 1 |
Cerinic, MM; Cutolo, M; Generini, S; Konttinen, Y | 1 |
Appelgren, A; Appelgren, B; Bileviciute, I; Carleson, J; Kopp, S; Lundeberg, T; Theodorsson, E; Yousef, N | 1 |
Luo, F | 1 |
Binder, W; Scott, C; Walker, JS | 1 |
Calvino, B; Grannec, G; Onténiente, B; Pezet, S | 1 |
Binder, W; Carmody, J; Walker, J | 1 |
Angelici, O; Bonanno, G; Carità, F; Clarke, GD; Raiteri, M; Schmid, G; Zaratin, P | 1 |
Harper, RP; Hinton, RJ; Hutchins, B; Spears, R | 1 |
Bellinger, DL; Engan, C; Felten, DL; Lorton, D; Lubahn, C; Schaller, J | 1 |
Schadrack, J; Zieglgänsberger, W | 1 |
Calvino, B; Grannec, G; Jullien, J; Junier, MP; Onténiente, B; Pezet, S; Rudkin, BB | 1 |
Bond, S; Bulling, DG; Kelly, D; McQueen, DS; Seckl, JR | 1 |
Herbert, MK; Schmidt, RF | 1 |
Butler, SH; Nyberg, F; Persson, S; Post, C; Weil-Fugazza, J | 1 |
Bellinger, DL; Felten, DL; Felten, SY; Lorton, D | 1 |
Donaldson, LF; Harmar, AJ; McQueen, DS; Seckl, JR | 1 |
Chrousos, GP; Crofford, LJ; Goldmuntz, EA; Karalis, K; Sano, H; Webster, EL; Wilder, RL | 1 |
Buma, P; Oestreicher, AB; Van der Kraan, P; Verschuren, C; Versleyen, D | 1 |
Cai, H; Cui, R; Ma, C; Tian, Y; Zhao, F; Zhu, L | 1 |
Hukkanen, M; Kemppinen, P; Konttinen, YT; Polak, JM; Rees, R; Saari, H; Santavirta, S; Segerberg, M; Sorsa, T | 1 |
Harmar, AJ; McQueen, DS; Seckl, JR; Smith, GD | 1 |
Holmdahl, R; Nyberg, F; Persson, S; Post, C | 1 |
Gibson, SJ; Hukkanen, M; Konttinen, YT; Polak, JM; Rees, RG; Santavirta, S | 1 |
Garzón, J; Lérida, M; Sánchez-Blázquez, P | 1 |
Duggan, AW; Hope, PJ; Jarrott, B; Schaible, HG | 1 |
Brewerton, DA; Gibson, SJ; Grönblad, M; Hukkanen, M; Konttinen, YT; Polak, JM; Rees, R; Tolvanen, E | 1 |
Brewerton, DA; Gibson, SJ; Grönblad, M; Hietanen, J; Hukkanen, M; Kottinen, YT; Polak, JM; Rees, R | 1 |
Brewerton, DA; Gibson, SJ; Jura, WG; Kar, S; Polak, JM; Rees, RG | 1 |
Marlier, L; Poulat, P; Privat, A; Rajaofetra, N | 1 |
Büchler, M; Friess, H; Müller, S; Nohr, D; Weihe, E; Zentel, HJ | 1 |
Basbaum, AI; Levine, JD; Moskowitz, MA | 1 |
Bernard, C; Chayvialle, JA; Chery-Croze, S; Kocher, L | 1 |
Oku, R; Satoh, M; Takagi, H | 1 |
Bianchi, M; Brini, A; Mantegazza, P; Panerai, AE; Sacerdote, P | 1 |
Gramsch, C; Herz, A; Millan, MJ; Müller, S; Nohr, D; Stein, C; Weihe, E | 1 |
Cao, WH; Deng, Y; Dong, XT; Lu, ZS; Zhang, TJ | 1 |
de Castro Costa, M; Gybels, J; Schoenen, J; Van Hees, J; Vanderhaeghen, JJ | 1 |
4 review(s) available for substance p and Adjuvant Arthritis
Article | Year |
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[Capsaicin for arthritic pain].
Topics: Analgesics; Animals; Arthritis; Arthritis, Experimental; Capsaicin; Humans; Pain; Substance P | 1996 |
Neuropeptides and steroid hormones in arthritis.
Topics: Animals; Arthritis; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Female; Gonadal Steroid Hormones; Humans; Hypothalamo-Hypophyseal System; Male; Neuropeptides; Pain; Peripheral Nerves; Pituitary-Adrenal System; Pregnancy; Steroids; Substance P | 1998 |
Activity-dependent changes in the pain matrix.
Topics: Animals; Arthritis, Experimental; Autoradiography; Carbon Radioisotopes; Deoxyglucose; Electrophysiology; Glutamic Acid; Motor Activity; Neurons; Pain; Rats; Receptors, Glutamate; Spinal Cord; Substance P; Synaptic Transmission | 2000 |
The tachykinin neuroimmune connection in inflammatory pain.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Genes, fos; Humans; Inflammation; Models, Neurological; Nervous System; Nervous System Physiological Phenomena; Neurons, Afferent; Neuropeptides; Pain; Rats; Substance P; Tachykinins | 1991 |
79 other study(ies) available for substance p and Adjuvant Arthritis
Article | Year |
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CCL17 in Inflammation and Pain.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Chemokine CCL17; Genes, Reporter; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Mice; Mice, Transgenic; Nerve Growth Factor; Pain; Pain Measurement; Peritonitis; Pneumonia; Signal Transduction; Substance P | 2020 |
The potential anti-inflammatory and anti-nociceptive effects of rat hemopressin (PVNFKFLSH) in experimental arthritis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Behavior, Animal; Cytokines; Edema; Gait; Hemoglobins; Inflammation; Injections, Intra-Articular; Knee Joint; Leukocytes; Male; Nociceptive Pain; Peptide Fragments; Rats, Sprague-Dawley; Receptors, Calcitonin Gene-Related Peptide; Substance P | 2021 |
Role of tachykinin 1 and 4 gene-derived neuropeptides and the neurokinin 1 receptor in adjuvant-induced chronic arthritis of the mouse.
Topics: Animals; Arthritis, Experimental; Edema; Freund's Adjuvant; Gene Expression Regulation; Hyperalgesia; Inflammation; Interleukin-1beta; Joints; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Plethysmography; Protein Precursors; Receptors, Neurokinin-1; Signal Transduction; Substance P; Tachykinins; Tarsus, Animal | 2013 |
Proteasome inhibitor MG132 modulates inflammatory pain by central mechanisms in adjuvant arthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Binding Sites; DNA; Female; Ganglia, Spinal; Leupeptins; Mycobacterium; NF-kappa B; Pain; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats, Inbred Lew; Spinal Cord; Substance P | 2017 |
[Effect of triptolide on iNOS and SP expressions in spinal dorsal horn and dorsal root ganglion of rats with adjuvant arthritis].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Diterpenes; Dose-Response Relationship, Drug; Epoxy Compounds; Female; Ganglia, Spinal; Immunohistochemistry; Male; Nitric Oxide Synthase Type II; Pain Measurement; Phenanthrenes; Phytotherapy; Random Allocation; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Time Factors; Treatment Outcome; Tripterygium | 2014 |
Intra-articular (IA) ropivacaine microparticle suspensions reduce pain, inflammation, cytokine, and substance p levels significantly more than oral or IA celecoxib in a rat model of arthritis.
Topics: Administration, Oral; Amides; Animals; Arthritis, Experimental; Celecoxib; Cytokines; Inflammation; Injections, Intra-Articular; Male; Microspheres; Pain; Rats; Ropivacaine; Substance P | 2015 |
Substance P ameliorates collagen II-induced arthritis in mice via suppression of the inflammatory response.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Progression; Humans; Immunosuppression Therapy; Interleukin-10; Interleukin-17; Macrophages; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred DBA; Substance P; T-Lymphocytes, Regulatory; Tumor Necrosis Factor-alpha | 2014 |
Antinociceptive effects of endomorphin-2: suppression of substance P release in the inflammatory pain model rat.
Topics: Animals; Arthritis, Experimental; Chronic Pain; Ganglia, Spinal; Hyperalgesia; Injections, Spinal; Male; Microdialysis; Microscopy, Electron; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Nociception; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Receptors, Presynaptic; Spinal Cord; Spinal Cord Dorsal Horn; Stress, Mechanical; Substance P; Tryptophan | 2015 |
Botulinum toxin type A reduces inflammatory hypernociception induced by arthritis in the temporomadibular joint of rats.
Topics: Analgesics; Animals; Arthritis, Experimental; Botulinum Toxins, Type A; Calcitonin Gene-Related Peptide; Injections, Intra-Articular; Interleukin-1beta; Male; Nociception; Rats; Rats, Wistar; Substance P; Temporomandibular Joint; Tumor Necrosis Factor-alpha | 2017 |
Reg-2 expression in dorsal root ganglion neurons after adjuvant-induced monoarthritis.
Topics: Animals; Arthritis, Experimental; Ganglia, Spinal; Gene Expression; Glial Cell Line-Derived Neurotrophic Factor; Indoles; Lectins; Leukemia Inhibitory Factor; Lithostathine; Male; Neurons; Proto-Oncogene Proteins c-ret; Rats; Rats, Wistar; Receptor, trkA; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Substance P; Time Factors | 2008 |
Substance P and glutamate receptor antagonists improve the anti-arthritic actions of dexamethasone in rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Dexamethasone; Drug Interactions; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Freund's Adjuvant; Glutamic Acid; Injections, Intra-Articular; Isoindoles; Knee Joint; Neurokinin-1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Neurokinin-1; Substance P; Time Factors | 2010 |
Effect of genetic deletion of the vanilloid receptor TRPV1 on the expression of Substance P in sensory neurons of mice with adjuvant-induced arthritis.
Topics: Animals; Arthritis, Experimental; Cell Count; Cell Size; Data Interpretation, Statistical; Fluorescent Antibody Technique; Ganglia, Spinal; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Fibers, Myelinated; Sensory Receptor Cells; Substance P; TRPV Cation Channels | 2010 |
Attenuation of pain and inflammation in adjuvant-induced arthritis by the proteasome inhibitor MG132.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Infectious; Biomarkers; Bone Density; Calcitonin Gene-Related Peptide; Cysteine Proteinase Inhibitors; DNA; Female; Joints; Leupeptins; Mycobacterium; Mycobacterium Infections; NF-kappa B; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Inbred Lew; Substance P | 2010 |
Suppression of pain and joint destruction by inhibition of the proteasome system in experimental osteoarthritis.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Cartilage, Articular; Cysteine Proteinase Inhibitors; Female; Ganglia, Spinal; Knee Joint; Leupeptins; Matrix Metalloproteinase 3; Osteoarthritis; Pain; Pain Measurement; Rats; Rats, Inbred Lew; Substance P | 2012 |
[Repeated 100 Hz TENS for the treatment of chronic inflammatory pain in rats: optimal parameters and possible neuro-chemical mechanisms].
Topics: Animals; Arthralgia; Arthritis, Experimental; Chronic Disease; Dynorphins; Naltrexone; Pain Threshold; Rats; Substance P; Transcutaneous Electric Nerve Stimulation | 1999 |
Time course and substance P effects on the vascular and morphological changes in adjuvant-induced monoarthritic rats.
Topics: Animals; Arthritis, Experimental; Capillary Permeability; Drug Synergism; Edema; Evans Blue; Freund's Adjuvant; Knee Joint; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Substance P; Time Factors | 2004 |
The role of substance P in microvascular responses in murine joint inflammation.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Freund's Adjuvant; Knee Joint; Mice; Mice, Inbred C57BL; Mice, Knockout; Microcirculation; Receptors, Neurokinin-1; Substance P | 2005 |
Increase in sensory neuropeptides surrounding the Achilles tendon in rats with adjuvant arthritis.
Topics: Achilles Tendon; Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Female; Galanin; Immunohistochemistry; Neuropeptides; Radioimmunoassay; Rats; Rats, Inbred Lew; Substance P | 2005 |
Stimulation of sensory neuropeptide release by nociceptin/orphanin FQ leads to hyperaemia in acutely inflamed rat knees.
Topics: Animals; Arthritis, Experimental; Capsaicin; Dose-Response Relationship, Drug; Hyperemia; Image Processing, Computer-Assisted; Joints; Kaolin; Leukocytes; Male; Mast Cells; Neuropeptides; Nociceptin; Opioid Peptides; Rats; Rats, Wistar; Regional Blood Flow; Stimulation, Chemical; Substance P; Synovial Fluid; Vasodilation | 2006 |
Anti-inflammatory effects of 4-phenyl-3-butenoic acid and 5-(acetylamino)-4-oxo-6-phenyl-2-hexenoic acid methyl ester, potential inhibitors of neuropeptide bioactivation.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Caproates; Cyclooxygenase 1; Cyclooxygenase 2; Dose-Response Relationship, Drug; Edema; Esters; Fatty Acids, Monounsaturated; Group II Phospholipases A2; Humans; In Vitro Techniques; Male; Molecular Structure; Neuropeptides; Phospholipases A; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Substance P | 2007 |
Effects of capsaicin on inflammation and on the substance P content of nervous tissues in rats with adjuvant arthritis.
Topics: Animals; Arthritis; Arthritis, Experimental; Capsaicin; Fatty Acids, Unsaturated; Inflammation; Kinetics; Male; Mycobacterium; Nervous System; Rats; Rats, Inbred Strains; Substance P | 1983 |
Respiratory effects of intrathecal capsaicin in arthritic and non-arthritic rats.
Topics: Animals; Arthritis; Arthritis, Experimental; Body Weight; Capsaicin; Injections, Spinal; Male; Pain; Rats; Rats, Inbred Strains; Respiration; Substance P | 1984 |
Endogenous substance P inhibits the expression of corticotropin-releasing hormone during a chronic inflammatory stress.
Topics: Adrenocorticotropic Hormone; Animals; Arthritis, Experimental; Chronic Disease; Corticotropin-Releasing Hormone; Hypothalamus; Inflammation; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stress, Physiological; Substance P | 1995 |
Effects of surgical denervation on substance P and calcitonin gene-related peptide in adjuvant arthritis.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Denervation; Female; Ganglia, Spinal; Immunohistochemistry; Radioimmunoassay; Rats; Rats, Inbred Lew; Sciatic Nerve; Substance P; Tarsus, Animal | 1995 |
Time-dependent changes in Bolton-Hunter-labeled 125I-substance P binding in rat spinal cord following unilateral adjuvant-induced peripheral inflammation.
Topics: Animals; Arthritis, Experimental; Autoradiography; Edema; Inflammation; Iodine Radioisotopes; Kinetics; Male; Neurons, Afferent; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Succinimides; Synapses; Synaptic Transmission | 1993 |
Behavioral and immunohistochemical changes in an experimental arthritis model in rats.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Calcitonin Gene-Related Peptide; Carrageenan; Glutamates; Glutamic Acid; Immunohistochemistry; Kaolin; Male; Neurotransmitter Agents; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Time Factors | 1993 |
Extraction of neuropeptides from joint tissue for quantitation by radioimmunoassay. A study in the rat.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Chromatography, High Pressure Liquid; Female; Knee Joint; Male; Neuropeptide Y; Neuropeptides; Radioimmunoassay; Rats; Substance P; Tissue Extracts; Vasoactive Intestinal Peptide | 1994 |
Altered calcitonin gene-related peptide, substance P and enkephalin immunoreactivities and receptor binding sites in the dorsal spinal cord of the polyarthritic rat.
Topics: Animals; Arthritis, Experimental; Autoradiography; Calcitonin Gene-Related Peptide; Enkephalins; Immunohistochemistry; In Vitro Techniques; Male; Neuropeptides; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Receptors, Opioid; Spinal Cord; Substance P | 1994 |
Alteration of substance P-mediated vasodilatation and sympathetic vasoconstriction in the rat knee joint by adjuvant-induced inflammation.
Topics: Animals; Arthritis, Experimental; Electric Stimulation; Freund's Adjuvant; Hindlimb; Image Processing, Computer-Assisted; Injections, Intra-Articular; Male; Rats; Rats, Wistar; Regional Blood Flow; Substance P; Sympathetic Nervous System; Vasoconstriction; Vasodilation | 1994 |
Prevaccination with diluted Freund adjuvant prevents the development of chronic pain and transient release of cerebrospinal fluid substance P in adjuvant-induced arthritis in rats.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Body Weight; Chronic Disease; Freund's Adjuvant; Hindlimb; Motor Activity; Pain; Pain Measurement; Rats; Substance P; Vaccination; Vocalization, Animal | 1994 |
Spinal cord SP release and hyperalgesia in monoarthritic rats: involvement of the GABAB receptor system.
Topics: Animals; Arthritis, Experimental; Bicuculline; Electric Stimulation; GABA-B Receptor Antagonists; Hyperalgesia; In Vitro Techniques; Male; Naloxone; Pain Measurement; Pain Threshold; Radioimmunoassay; Rats; Rats, Inbred Lew; Receptors, GABA-B; Spinal Cord; Substance P; Weight Loss | 1994 |
Capsaicin effects on substance P and CGRP in rat adjuvant arthritis.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Capsaicin; Female; Ganglia, Spinal; Immunohistochemistry; Organ Size; Rats; Rats, Inbred Lew; Substance P; Synovial Membrane; Tarsus, Animal; Up-Regulation | 1995 |
Increased levels of substance P and calcitonin gene-related peptide in rat adjuvant arthritis. A combined immunohistochemical and radioimmunoassay analysis.
Topics: Animals; Ankle Joint; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Chromatography, High Pressure Liquid; Disease Models, Animal; Female; Ganglia, Spinal; Immunohistochemistry; Microscopy, Fluorescence; Radioimmunoassay; Rats; Rats, Inbred Lew; Skin; Substance P; Synovial Membrane | 1995 |
Changes in preprotachykinin mRNA expression and substance P levels in dorsal root ganglia of monoarthritic rats: comparison with changes in synovial substance P levels.
Topics: Animals; Arthritis, Experimental; Blotting, Northern; Ganglia, Spinal; Male; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Substance P; Synovial Fluid; Tachykinins | 1995 |
Prolonged alteration of vasoconstrictor and vasodilator responses in rat knee joints by adjuvant monoarthritis.
Topics: Animals; Arthritis, Experimental; Blood Flow Velocity; Electric Stimulation; Freund's Adjuvant; Joint Capsule; Knee Joint; Laser-Doppler Flowmetry; Male; Rats; Rats, Wistar; Substance P; Vasoconstriction; Vasodilation | 1995 |
Maintained peptidergic innervation of the knee joint in an animal model of antigen-induced arthritis.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Cats; Joints; Nerve Fibers; Substance P; Synovial Membrane | 1993 |
In vitro and in vivo studies of substance P receptor expression in rats with the new analog [indium-111-DTPA-Arg1]substance P.
Topics: Animals; Arthritis, Experimental; Biphenyl Compounds; Female; Indium Radioisotopes; Male; Neurokinin-1 Receptor Antagonists; Pancreatic Neoplasms; Parotid Gland; Pentetic Acid; Radionuclide Imaging; Rats; Rats, Inbred Lew; Rats, Wistar; Receptors, Neurokinin-1; Submandibular Gland; Substance P; Tissue Distribution | 1996 |
Evidence for altered control of hypothalamic CRF in immune-mediated diseases.
Topics: Acute Disease; Animals; Arginine Vasopressin; Arthritis, Experimental; Chronic Disease; Corticotropin-Releasing Hormone; Hypothalamo-Hypophyseal System; Hypothalamus; Inflammation; Mice; Paraventricular Hypothalamic Nucleus; Pituitary-Adrenal System; Stress, Physiological; Substance P | 1995 |
Is the pretreatment effect of low dose Freund's adjuvant on adjuvant arthritis due to an activation of the nervous system?
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Freund's Adjuvant; Immunization; Male; Neurokinin A; Neuropeptide Y; Rats; Rats, Sprague-Dawley; Substance P; Synovial Fluid | 1996 |
Microtopography of the autonomic nerves in the rat knee: a fluorescence microscopic study.
Topics: Animals; Arthritis, Experimental; Autonomic Pathways; Bone and Bones; Calcitonin Gene-Related Peptide; Immunohistochemistry; Knee Joint; Ligaments; Microscopy, Confocal; Microscopy, Fluorescence; Neurokinin A; Rats; Rats, Wistar; Substance P; Synovial Membrane; Tendons | 1997 |
Effects of adjuvant on neuropeptide-like immunoreactivity in experimentally induced temporomandibular arthritis in rats.
Topics: Animals; Arthritis, Experimental; Bacterial Proteins; Calcitonin Gene-Related Peptide; Immunohistochemistry; Male; Mycobacterium; Neuroimmunomodulation; Neurokinin A; Neuropeptide Y; Neuropeptides; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Substance P; Synovial Fluid; Temporomandibular Joint Disorders | 1996 |
Effect of capsaicin on substance P and nerve growth factor in adjuvant arthritic rats.
Topics: Animals; Arthritis, Experimental; Capsaicin; Ganglia, Spinal; Male; Nerve Growth Factors; Protein Precursors; Proto-Oncogene Proteins; Rats; Rats, Wistar; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; Reference Values; RNA, Messenger; Sciatic Nerve; Skin; Substance P; Tachykinins; Transcription, Genetic | 1997 |
A single capsaicin injection partially depletes neuropeptides but does not ameliorate inflammation severity in established feline antigen induced arthritis.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Capsaicin; Cats; Immunohistochemistry; Injections, Intra-Articular; Knee Joint; Substance P; Synovial Membrane; Synovitis | 1997 |
Ultrastructure of the synovial sensory peptidergic fibers is distinctively altered in different phases of adjuvant induced arthritis in rats: ultramorphological characterization combined with morphometric and immunohistochemical study for substance P, cal
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Immunohistochemistry; Male; Microscopy, Electron; Microscopy, Immunoelectron; Nerve Tissue Proteins; Neurons, Afferent; Neuropeptides; Rats; Rats, Wistar; Substance P; Synovial Membrane; Thiolester Hydrolases; Time Factors; Ubiquitin Thiolesterase | 1997 |
[The role of substance P in the spinal dorsal horn in the pathogenesis of autoimmune diseases].
Topics: Animals; Arthritis, Experimental; Autoimmune Diseases; Encephalomyelitis, Autoimmune, Experimental; Guinea Pigs; Male; Neuritis, Autoimmune, Experimental; Rats; Rats, Wistar; Spinal Cord; Substance P | 1996 |
Effects of adjuvant on neuropeptide-like immunoreactivity in the temporomandibular joint and trigeminal ganglia.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Chromatography, High Pressure Liquid; Female; Neuroimmunomodulation; Neuropeptide Y; Neuropeptides; Radioimmunoassay; Rats; Rats, Inbred Lew; Substance P; Temporomandibular Joint; Temporomandibular Joint Disorders; Trigeminal Ganglion | 1997 |
[A study on the cumulative effect of repeated electroacupuncture on chronic pain].
Topics: Acupuncture Analgesia; Animals; Arthritis, Experimental; Chronic Disease; Electroacupuncture; Humans; Pain Management; Rats; Sincalide; Substance P | 1996 |
Involvement of substance P in the anti-inflammatory effects of the peripherally selective kappa-opioid asimadoline and the NK1 antagonist GR205171.
Topics: Acetamides; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Disease Progression; Dose-Response Relationship, Drug; Joints; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrrolidines; Rats; Substance P; Tetrazoles | 1999 |
Chronic pain is associated with increased TrkA immunoreactivity in spinoreticular neurons.
Topics: Afferent Pathways; Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Cell Count; Cell Size; Chronic Disease; Immunohistochemistry; Lumbosacral Region; Male; Nerve Growth Factors; Neuronal Plasticity; Neurons; Pain; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; Spinal Cord; Substance P | 1999 |
Effect of gender on anti-inflammatory and analgesic actions of two kappa-opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetamides; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Arthritis; Arthritis, Experimental; Female; Hot Temperature; Male; Narcotics; Pain Measurement; Physical Stimulation; Pyrrolidines; Rats; Sex Characteristics; Substance P; Time Factors | 2000 |
NK3 receptor blockade prevents hyperalgesia and the associated spinal cord substance P release in monoarthritic rats.
Topics: Afferent Pathways; Animals; Arthritis, Experimental; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Pain; Peptide Fragments; Quinolines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-3; Spinal Cord; Substance P | 2000 |
Calcitonin gene-related peptide and substance P immunoreactivity in rat trigeminal ganglia and brainstem following adjuvant-induced inflammation of the temporomandibular joint.
Topics: Afferent Pathways; Animals; Arthritis, Experimental; Brain Stem; Calcitonin Gene-Related Peptide; Cartilage, Articular; Edema; Freund's Adjuvant; Male; Pharmaceutical Vehicles; Rats; Rats, Sprague-Dawley; Substance P; Temporomandibular Joint; Temporomandibular Joint Disc; Temporomandibular Joint Disorders; Time Factors; Trigeminal Ganglion; Trigeminal Nuclei | 2000 |
Local application of capsaicin into the draining lymph nodes attenuates expression of adjuvant-induced arthritis.
Topics: Afferent Pathways; Animals; Arthritis, Experimental; Capsaicin; Denervation; Freund's Adjuvant; Hindlimb; Injections, Intralymphatic; Lymph Nodes; Male; Nerve Fibers; Rats; Rats, Inbred Lew; Substance P | 2000 |
Differential regulation of NGF receptors in primary sensory neurons by adjuvant-induced arthritis in the rat.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Ganglia, Spinal; Male; Neurons, Afferent; Posterior Horn Cells; Proteins; Rats; Rats, Sprague-Dawley; Receptor, Nerve Growth Factor; Receptor, trkA; Receptors, Nerve Growth Factor; RNA, Messenger; Substance P | 2001 |
Adjuvant-induced joint inflammation causes very rapid transcription of beta-preprotachykinin and alpha-CGRP genes in innervating sensory ganglia.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Cell Size; Cycloheximide; Freund's Adjuvant; Ganglia, Spinal; Gene Expression Regulation; In Situ Hybridization; Injections; Male; Neurons, Afferent; Pressure; Protein Precursors; Protein Synthesis Inhibitors; Radioimmunoassay; Rats; Rats, Wistar; Reflex; RNA, Messenger; Sciatic Nerve; Substance P; Synaptic Transmission; Tachykinins; Tarsus, Animal; Time Factors; Transcription, Genetic | 2001 |
Sensitisation of group III articular afferents to mechanical stimuli by substance P.
Topics: Animals; Arthritis, Experimental; Cartilage, Articular; Cats; Evoked Potentials; Female; Hindlimb; Histamine; Male; Movement; Neurons, Afferent; Physical Stimulation; Stimulation, Chemical; Substance P | 2001 |
Decreased cerebrospinal fluid neuropeptide-converting enzyme activity in monoarthritic rats.
Topics: Animals; Arthritis, Experimental; Cerebrospinal Fluid; Cysteine Endopeptidases; Enkephalin, Leucine; Male; Metalloendopeptidases; Pain; Peptide Fragments; Rats; Rats, Sprague-Dawley; Substance P | 1992 |
Noradrenergic and peptidergic innervation of secondary lymphoid organs: role in experimental rheumatoid arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Denervation; Disease Models, Animal; In Vitro Techniques; Lymphoid Tissue; Male; Nerve Fibers; Norepinephrine; Rats; Rats, Inbred Lew; Substance P | 1992 |
Increased expression of preprotachykinin, calcitonin gene-related peptide, but not vasoactive intestinal peptide messenger RNA in dorsal root ganglia during the development of adjuvant monoarthritis in the rat.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Ganglia, Spinal; Genetic Code; In Situ Hybridization; Male; Nerve Tissue Proteins; Protein Precursors; Rats; Rats, Wistar; RNA Probes; Substance P; Tachykinins; Vasoactive Intestinal Peptide | 1992 |
Local secretion of corticotropin-releasing hormone in the joints of Lewis rats with inflammatory arthritis.
Topics: Animals; Arthritis; Arthritis, Experimental; Corticotropin-Releasing Hormone; Dexamethasone; Gene Expression; Inflammation; Joints; Male; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Nude; RNA, Messenger; Substance P; Synovial Membrane | 1992 |
Calcitonin gene-related peptide, substance P and GAP-43/B-50 immunoreactivity in the normal and arthrotic knee joint of the mouse.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Collagenases; Connexins; Immunohistochemistry; Knee Joint; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Substance P; Tissue Fixation | 1992 |
[Influence of 5.7-dihydroxytryptamine on electro-acupuncture analgesia and substance P level in central nervous system of the arthralgic rats].
Topics: Acupuncture Analgesia; Animals; Arthritis, Experimental; Brain Stem; Dihydroxytryptamines; Electroacupuncture; Pain Threshold; Rats; Rats, Wistar; Spinal Cord; Substance P | 1992 |
Relationship between neuropeptide immunoreactive nerves and inflammatory cells in adjuvant arthritic rats.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Neurons; Neuropeptides; Rats; Substance P; Synovial Membrane; Synovitis | 1992 |
Increase in substance P and CGRP, but not somatostatin content of innervating dorsal root ganglia in adjuvant monoarthritis in the rat.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Corticosterone; Ganglia, Spinal; Male; Rats; Rats, Inbred Strains; Somatostatin; Substance P | 1992 |
Decreased neuropeptide-converting enzyme activities in cerebrospinal fluid during acute but not chronic phases of collagen induced arthritis in rats.
Topics: Acute Disease; Amino Acid Sequence; Analysis of Variance; Animals; Arthritis, Experimental; Chromatography, High Pressure Liquid; Chronic Disease; Collagen; Cysteine Endopeptidases; Dynorphins; Hemoglobins; Metalloendopeptidases; Molecular Sequence Data; Rats; Rats, Wistar; Regression Analysis; Substance P; Time Factors | 1992 |
Innervation of bone from healthy and arthritic rats by substance P and calcitonin gene related peptide containing sensory fibers.
Topics: Animals; Arthritis, Experimental; Bone and Bones; Bone Marrow; Calcitonin Gene-Related Peptide; Disease Models, Animal; Growth Plate; Immunohistochemistry; Male; Neurons, Afferent; Periosteum; Rats; Stress, Mechanical; Substance P | 1992 |
Effect of intrathecal injection of pertussis toxin on substance P, norepinephrine and serotonin contents in various neural structures of arthritic rats.
Topics: Animals; Arthritis, Experimental; Brain; Freund's Adjuvant; Hydroxyindoleacetic Acid; Injections, Spinal; Male; Nociceptors; Norepinephrine; Pain; Pertussis Toxin; Pons; Rats; Rats, Inbred Strains; Serotonin; Spinal Cord; Substance P; Thalamus; Virulence Factors, Bordetella | 1990 |
Release of immunoreactive substance P in the spinal cord during development of acute arthritis in the knee joint of the cat: a study with antibody microprobes.
Topics: Animals; Arthritis, Experimental; Carrageenan; Cats; Immunoassay; Inflammation; Joints; Kaolin; Pressure; Reference Values; Spinal Cord; Substance P | 1990 |
Nerves in inflammatory synovium: immunohistochemical observations on the adjuvant arthritis rat model.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Calcitonin Gene-Related Peptide; Disease Models, Animal; Humans; Immune Sera; Immunohistochemistry; Neuropeptides; Rats; Substance P; Synovial Membrane; Synovitis; Ubiquitin Thiolesterase | 1990 |
Regional distribution of mast cells and peptide containing nerves in normal and adjuvant arthritic rat synovium.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Heparin; Immunohistochemistry; Mast Cells; Nervous System; Neuropeptides; Peptides; Rats; Substance P; Synovial Membrane; Ubiquitin Thiolesterase | 1991 |
Increased calcitonin gene-related peptide (CGRP), substance P, and enkephalin immunoreactivities in dorsal spinal cord and loss of CGRP-immunoreactive motoneurons in arthritic rats depend on intact peripheral nerve supply.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Enkephalins; Functional Laterality; Ganglia, Spinal; Immunoenzyme Techniques; Male; Motor Neurons; Rats; Rats, Inbred Strains; Reference Values; Sciatic Nerve; Spinal Cord; Substance P | 1991 |
Modifications of serotonin-, substance P- and calcitonin gene-related peptide-like immunoreactivities in the dorsal horn of the spinal cord of arthritic rats: a quantitative immunocytochemical study.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Immunohistochemistry; Male; Rats; Rats, Inbred Strains; Serotonin; Spinal Cord; Substance P; Time Factors | 1991 |
The contribution of neurogenic inflammation in experimental arthritis.
Topics: Animals; Arthritis; Arthritis, Experimental; Arthritis, Rheumatoid; Brain Stem; Humans; Inflammation; Nociceptors; Pain; Rats; Spinal Cord; Substance P; Sympathetic Nervous System | 1985 |
Substance P-, somatostatin-, vasoactive intestinal peptide- and cholecystokinin-like levels in the spinal cord of polyarthritic rats.
Topics: Animals; Arthritis; Arthritis, Experimental; Cholecystokinin; Peptides; Rats; Rats, Inbred Strains; Somatostatin; Spinal Cord; Substance P; Vasoactive Intestinal Peptide | 1985 |
Release of substance P from the spinal dorsal horn is enhanced in polyarthritic rats.
Topics: Animals; Arthritis; Arthritis, Experimental; Decerebrate State; Male; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Synaptic Transmission | 1987 |
Brain and spinal cord neuropeptides in adjuvant induced arthritis in rats.
Topics: Animals; Arthritis; Arthritis, Experimental; beta-Endorphin; Brain; Dynorphins; Endorphins; Enkephalin, Methionine; Male; Neuropeptides; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Time Factors; Tissue Distribution | 1987 |
Peptide neuroanatomy of adjuvant-induced arthritic inflammation in rat.
Topics: Animals; Arthritis; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Enkephalins; Ganglia, Spinal; Immunohistochemistry; Nerve Fibers; Neuropeptides; Protein Precursors; Rats; Rats, Inbred Strains; Skin; Spinal Cord; Substance P | 1988 |
Relation between the therapeutic effect of moxibustion in treating arthralgia and SP and enkephalin in nervous tissues.
Topics: Animals; Arthritis; Arthritis, Experimental; Enkephalin, Leucine; Male; Moxibustion; Pain; Rats; Rats, Inbred Strains; Sciatic Nerve; Sensory Thresholds; Spinal Cord; Substance P | 1989 |
Histochemical changes of substance P, FRAP, serotonin and succinic dehydrogenase in the spinal cord of rats with adjuvant arthritis.
Topics: Acid Phosphatase; Animals; Arthritis; Arthritis, Experimental; Behavior, Animal; Fluorides; Histocytochemistry; Isoenzymes; Male; Rats; Rats, Inbred Strains; Serotonin; Spinal Cord; Substance P; Succinate Dehydrogenase; Time Factors | 1985 |