substance-p--pro(2)-phe(7)-trp(9)- and Hypertension--Renovascular

substance-p--pro(2)-phe(7)-trp(9)- has been researched along with Hypertension--Renovascular* in 1 studies

Other Studies

1 other study(ies) available for substance-p--pro(2)-phe(7)-trp(9)- and Hypertension--Renovascular

Article	Year
[The changes of substance P contents in central nervous system of renal hypertensive rats]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1992, Volume: 14, Issue:2 The changes of substance P-like immunoreactivity (SPLI) were determined in the central nervous system of renal hypertensive rats (produced by application of a constricting clip on the left renal artery), as compared with those of sham-operated controls. The results showed that the substance SP (SP) contents in the rostral ventrolateral medulla (RVM) and intermediolateral cell column (IML) of the thoracic spinal cord in renal hypertensive rats (RHR) were significantly higher than those in the control group. On the other hand, there was no significant difference of SP content in the hypothalamus (HP) between RHR and control groups. Intrathecal injection of SP antagonist lowered the mean blood pressure in both RHR and control groups. This data suggests that the excess SP contents in RVM and IML may be closely related to the pathogenesis of hypertension. Topics: Animals; Blood Pressure; Hypertension, Renovascular; Medulla Oblongata; Rats; Rats, Inbred Strains; Spinal Cord; Substance P	1992

Article

Year

[The changes of substance P contents in central nervous system of renal hypertensive rats].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1992, Volume: 14, Issue:2

The changes of substance P-like immunoreactivity (SPLI) were determined in the central nervous system of renal hypertensive rats (produced by application of a constricting clip on the left renal artery), as compared with those of sham-operated controls. The results showed that the substance SP (SP) contents in the rostral ventrolateral medulla (RVM) and intermediolateral cell column (IML) of the thoracic spinal cord in renal hypertensive rats (RHR) were significantly higher than those in the control group. On the other hand, there was no significant difference of SP content in the hypothalamus (HP) between RHR and control groups. Intrathecal injection of SP antagonist lowered the mean blood pressure in both RHR and control groups. This data suggests that the excess SP contents in RVM and IML may be closely related to the pathogenesis of hypertension.

Topics: Animals; Blood Pressure; Hypertension, Renovascular; Medulla Oblongata; Rats; Rats, Inbred Strains; Spinal Cord; Substance P

1992