su-5402 and Tympanic-Membrane-Perforation

su-5402 has been researched along with Tympanic-Membrane-Perforation* in 1 studies

Other Studies

1 other study(ies) available for su-5402 and Tympanic-Membrane-Perforation

Article	Year
Inhibition of fibroblast growth factor receptor 1: influence on tympanic membrane wound healing in rats. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2012, Volume: 269, Issue:1 An animal model of chronic tympanic membrane (TM) perforation is needed for experiments on supporting healing of TM perforations. The basic fibroblast growth factor is important in TM wound healing. The object of this study was to investigate the efficacy of fibroblast growth factor receptor 1 (FGFR1) inhibition to arrest wound healing of experimental TM perforation. Bilateral instrumental myringotomies were performed in 12 rats. A specific inhibitor of the FGFR1 tyrosine kinase (SU5402) was applied to the left TM (2 mg/ml) and to the right TM (10 mg/ml) of each animal daily for 12 consecutive days. Thereafter, TMs were observed weekly for a total of 30 days. TM healing was delayed in a dose-dependent manner. We observed differences in the histologic parameters between both groups. SU 5402 is a strong inhibitor of TM healing but seems not to be suitable to create a chronic TM perforation in rat. Topics: Animals; Dose-Response Relationship, Drug; Female; Male; Protein-Tyrosine Kinases; Pyrroles; Rats; Rats, Inbred Lew; Receptor, Fibroblast Growth Factor, Type 1; Tympanic Membrane; Tympanic Membrane Perforation; Wound Healing	2012

Article

Year

Inhibition of fibroblast growth factor receptor 1: influence on tympanic membrane wound healing in rats.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2012, Volume: 269, Issue:1

An animal model of chronic tympanic membrane (TM) perforation is needed for experiments on supporting healing of TM perforations. The basic fibroblast growth factor is important in TM wound healing. The object of this study was to investigate the efficacy of fibroblast growth factor receptor 1 (FGFR1) inhibition to arrest wound healing of experimental TM perforation. Bilateral instrumental myringotomies were performed in 12 rats. A specific inhibitor of the FGFR1 tyrosine kinase (SU5402) was applied to the left TM (2 mg/ml) and to the right TM (10 mg/ml) of each animal daily for 12 consecutive days. Thereafter, TMs were observed weekly for a total of 30 days. TM healing was delayed in a dose-dependent manner. We observed differences in the histologic parameters between both groups. SU 5402 is a strong inhibitor of TM healing but seems not to be suitable to create a chronic TM perforation in rat.

Topics: Animals; Dose-Response Relationship, Drug; Female; Male; Protein-Tyrosine Kinases; Pyrroles; Rats; Rats, Inbred Lew; Receptor, Fibroblast Growth Factor, Type 1; Tympanic Membrane; Tympanic Membrane Perforation; Wound Healing

2012