su-5402 and Myocardial-Ischemia

We sought to investigate the role of fibroblast growth factor (FGF)-1 during acute myocardial ischemia and reperfusion.. The FGFs display cardioprotective effects during ischemia and reperfusion.. We investigated FGF-1-induced cardioprotection during ischemia and reperfusion and the intracellular signaling pathways responsible for these effects in an ex vivo murine setup of myocardial ischemia and reperfusion.. Cardiac-specific human FGF-1 overexpression was associated with enhanced post-ischemic hemodynamic recovery and decreased lactate dehydrogenase release during reperfusion. Inhibition of the FGF receptor, protein kinase C (PKC), and tyrosine kinase (TK) resulted in blockade of FGF-1-induced protective effects on cardiac functional recovery and cell death.. The overexpression of FGF-1 induces cardioprotection through a pathway that involves the FGF receptor, PKC, and TK.

Topics: Animals; Blotting, Western; Cell Survival; Fibroblast Growth Factor 1; Heart Ventricles; Hemodynamics; Immunohistochemistry; In Vitro Techniques; Male; Mice; Mice, Transgenic; Myocardial Ischemia; Myocardial Reperfusion; Precipitin Tests; Protein Kinase C; Protein-Tyrosine Kinases; Pyrroles; Receptors, Fibroblast Growth Factor; Recovery of Function; Signal Transduction