su-5402 and Colonic-Neoplasms

su-5402 has been researched along with Colonic-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for su-5402 and Colonic-Neoplasms

Article	Year
Synthesis of 1-(2,6-dichlorophenyl)-3-methylene-1,3-dihydro-indol-2-one derivatives and in vitro anticancer evaluation against SW620 colon cancer cell line. European journal of medicinal chemistry, 2009, Volume: 44, Issue:3 A small library of 2-indolinone derivatives with the 2,6-dichlorophenyl ring at the N(1) position and with varying substitutions including aryl groups at the 3-position were synthesized, and their structures were confirmed by spectral analysis. All molecules were screened for their in vitro cytotoxic activity on SW620 colon cancer cell lines. Among the designed series compounds 4c, 4f and 4j were found to be active at concentrations of 2-15 microg/ml. Some 3D-QSAR models were also built to understand the structure-activity relationship. Topics: Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Drug Screening Assays, Antitumor; Humans; Indoles; Magnetic Resonance Spectroscopy; Quantitative Structure-Activity Relationship; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Infrared	2009

Article

Year

Synthesis of 1-(2,6-dichlorophenyl)-3-methylene-1,3-dihydro-indol-2-one derivatives and in vitro anticancer evaluation against SW620 colon cancer cell line.

European journal of medicinal chemistry, 2009, Volume: 44, Issue:3

A small library of 2-indolinone derivatives with the 2,6-dichlorophenyl ring at the N(1) position and with varying substitutions including aryl groups at the 3-position were synthesized, and their structures were confirmed by spectral analysis. All molecules were screened for their in vitro cytotoxic activity on SW620 colon cancer cell lines. Among the designed series compounds 4c, 4f and 4j were found to be active at concentrations of 2-15 microg/ml. Some 3D-QSAR models were also built to understand the structure-activity relationship.

Topics: Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Drug Screening Assays, Antitumor; Humans; Indoles; Magnetic Resonance Spectroscopy; Quantitative Structure-Activity Relationship; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Infrared

2009