strychnine and Trichomonas-Infections

In an earlier paper we described the synthesis and the antitrichomonas activity of 2-nitro-alpha,alpha,1-trimethyl-1H-imidazole-5-methanol (2). Starting from this compound, several derivatives have been synthesized. Among these, the phenyl carbonate 8 has been shown to possess activity equal to that of 2 and to be less toxic. This compound therefore is interesting in comparison with some antitrichomonas agents currently in use clinically. Before undertaking an in-depth investigation, compound 8 was subjected to some studies to see whether it has any effects on the central nervous system (CNS). Preliminary results show that, at therapeutic doses, it might induce unwanted CNS effects to a lesser degree than metronidazole.

Topics: Animals; Antitrichomonal Agents; Clostridium perfringens; Drug Interactions; Hexobarbital; Male; Mice; Microbial Sensitivity Tests; Mycoplasma; Nitroimidazoles; Pentylenetetrazole; Sleep; Staphylococcus aureus; Streptococcus pyogenes; Strychnine; Trichomonas Infections; Trichomonas vaginalis