strychnine and Infant--Newborn--Diseases

strychnine has been researched along with Infant--Newborn--Diseases* in 2 studies

Other Studies

2 other study(ies) available for strychnine and Infant--Newborn--Diseases

Article	Year
Failure of strychnine treatment during the neonatal period in three Finnish children with nonketotic hyperglycinemia. Pediatrics, 1980, Volume: 65, Issue:6 Three Finnish infants with a severe neonatal-onset-type of nonketotic hyperglycinemia were treated with strychnine nitrate in a daily dosage of 0.2 to 0.9 mg/kg, given orally in four doses. In order to lower the plasma and CSF-glycine concentrations concomitant exchange transfusions (200 to 300 ml/kg of heparinized blood) were carried out in two of these infants. Although the strychnine therapy was started at ages 15, 40, and 62 hours, the strychnine produced no clinical effect, and the exchange transfusion caused only a transient decrease in the plasma glycine level. Despite treatment, the clinical course was the same as in the majority of children with the severe form of the disease--all died within the first ten days of life. Impressive effects of strychnine treatment initiated in two infants at ages 5 and 6 1/2 months, and given in addition to sodium benzoate and anticonvulsants, have been reported. These cases, however, probably represent a less severe type of nonketotic hyperglycinemia. Nevertheless, the therapeutic failure in the present cases probably indicates that strychnine treatment does not solve the therapeutic problems of severe forms of NKH. Topics: Amino Acid Metabolism, Inborn Errors; Exchange Transfusion, Whole Blood; Female; Glycine; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Strychnine	1980
Strychnine treatment attempted in newborn twins with severe nonketotic hyperglycinemia. Helvetica paediatrica acta, 1979, Volume: 34, Issue:6 Strychnine, a potent antagonist of glycine was given to twins suffering from nonketotic hyperglycinemia at age 73 hours. Within hours of the onset of treatment favorable effects were observed such as improvements of muscle tone, movements, defense reactions, and probably breathing. Pyridoxine, N5-formyl-tetrahydrofolate and lipoic acid were given concomitantly with strychnine but failed to alter glycine levels in plasma and cerebrospinal fluid. The therapeutic trial was terminated after 2 1/2 days because success, though considerable, was judged inadequate. Topics: Diseases in Twins; Electroencephalography; Female; Glycine; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Strychnine	1979

Article

Year

Failure of strychnine treatment during the neonatal period in three Finnish children with nonketotic hyperglycinemia.

Pediatrics, 1980, Volume: 65, Issue:6

Three Finnish infants with a severe neonatal-onset-type of nonketotic hyperglycinemia were treated with strychnine nitrate in a daily dosage of 0.2 to 0.9 mg/kg, given orally in four doses. In order to lower the plasma and CSF-glycine concentrations concomitant exchange transfusions (200 to 300 ml/kg of heparinized blood) were carried out in two of these infants. Although the strychnine therapy was started at ages 15, 40, and 62 hours, the strychnine produced no clinical effect, and the exchange transfusion caused only a transient decrease in the plasma glycine level. Despite treatment, the clinical course was the same as in the majority of children with the severe form of the disease--all died within the first ten days of life. Impressive effects of strychnine treatment initiated in two infants at ages 5 and 6 1/2 months, and given in addition to sodium benzoate and anticonvulsants, have been reported. These cases, however, probably represent a less severe type of nonketotic hyperglycinemia. Nevertheless, the therapeutic failure in the present cases probably indicates that strychnine treatment does not solve the therapeutic problems of severe forms of NKH.

Topics: Amino Acid Metabolism, Inborn Errors; Exchange Transfusion, Whole Blood; Female; Glycine; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Strychnine

1980

Strychnine treatment attempted in newborn twins with severe nonketotic hyperglycinemia.

Helvetica paediatrica acta, 1979, Volume: 34, Issue:6

Strychnine, a potent antagonist of glycine was given to twins suffering from nonketotic hyperglycinemia at age 73 hours. Within hours of the onset of treatment favorable effects were observed such as improvements of muscle tone, movements, defense reactions, and probably breathing. Pyridoxine, N5-formyl-tetrahydrofolate and lipoic acid were given concomitantly with strychnine but failed to alter glycine levels in plasma and cerebrospinal fluid. The therapeutic trial was terminated after 2 1/2 days because success, though considerable, was judged inadequate.

Topics: Diseases in Twins; Electroencephalography; Female; Glycine; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Strychnine

1979