strychnine and Hypothermia

The psychopharmacological effects of a number of thieno and pyrazolo[2,1] benzothiazepine derivatives as well as several synthetic intermediate compounds were investigated in mice. Previously published studies in mice have shown that some of these compounds were effective in the tetrabenazine and Porsolt tests. In the present study, 7 of the 15 compounds under study clearly antagonized the apomorphine (16 mg/kg s.c.)-induced hypothermia, but no significant potentiation of the 5-hydroxytryptophan (5-HTP) and amphetamine actions was found. Five of them inhibited the syndrome induced by 5-HTP (250 mg/kg i.p.). Moreover, some of them were effective in the plus-maze test and antagonized the apomorphine (3 mg/kg s.c.)-induced effects. On the other hand, these compounds produced a moderate inhibition of exploratory behaviour in the hole-board test, but they had no significant muscle relaxant and anticonvulsant activities. The results indicate that some of the compounds under study combine a spectrum of antidepressant, anxiolytic and neuroleptic properties in mice with a lack of muscle relaxant and anticonvulsant activities.

Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents, Tricyclic; Apomorphine; Behavior, Animal; Body Temperature; Convulsants; Dextroamphetamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Exploratory Behavior; Female; Hypothermia; Male; Mice; Motor Activity; Muscle Relaxants, Central; Serotonin; Stereotyped Behavior; Strychnine; Thiazepines

Topics: Anesthesia; Animals; Atropine; Barbiturates; Behavior, Animal; Cats; Central Nervous System; Depression, Chemical; Drug Synergism; Ethanol; Ethers; Fever; Haplorhini; Hypothermia; Imipramine; Male; Mice; Norepinephrine; Oxazines; Pentylenetetrazole; Rats; Reserpine; Stimulation, Chemical; Strychnine; Tremorine

Topics: Animals; Central Nervous System; Depression, Chemical; Electroshock; Hypothermia; Male; Mice; Nicotine; Oxazines; Pentylenetetrazole; Strychnine

Topics: Acceleration; Body Temperature Regulation; Electric Stimulation; Hypothermia; Hypoxia; Mice; Rats; Research; Strychnine; Toxicology

Topics: Amitriptyline; Animals; Antidepressive Agents; Caffeine; Desipramine; Hypothermia; Hypothermia, Induced; Imipramine; Injections, Intraperitoneal; Mice; Nortriptyline; Pentylenetetrazole; Peptic Ulcer; Rats; Research; Reserpine; Selective Serotonin Reuptake Inhibitors; Serotonin; Strychnine; Toxicology; Tranquilizing Agents

Topics: Animals; Blood Pressure; Body Temperature; Body Temperature Regulation; Brain; Carotid Arteries; Carotid Artery, Common; Chlorpromazine; Heart; Hypothalamus; Hypothermia; Lipopolysaccharides; Pentobarbital; Pharmacology; Pyrogens; Rabbits; Research; Respiration; Strychnine; Temperature; Tympanic Membrane

Topics: Cats; Cochlea; Ear, Inner; Hearing; Hypothermia; Neurochemistry; Neurophysiology; Olivary Nucleus; Research; Strychnine; Temperature

Topics: Animals; Bemegride; Brain; Central Nervous System Stimulants; Cerebral Cortex; Cerebral Ventricles; Dogs; Electroencephalography; Electrophysiology; Hypothermia; Hypothermia, Induced; Pentylenetetrazole; Physiology; Research; Strychnine

Topics: Cerebral Cortex; Electroencephalography; Hypothermia; Hypothermia, Induced; Strychnine

Topics: Carbon Monoxide; Carbon Monoxide Poisoning; Humans; Hypothermia; Strychnine

Topics: Body Temperature; Carbon Monoxide; Carbon Monoxide Poisoning; Hypothermia; Strychnine