strychnine and Coma

strychnine has been researched along with Coma* in 9 studies

Reviews

1 review(s) available for strychnine and Coma

ArticleYear
[TREATMENT OF ACUTE BARBITURATE POISONING].
    Acta clinica Belgica, 1963, Volume: 18

    Topics: Amphetamine; Amphetamines; Barbiturates; Bemegride; Coma; Humans; Nikethamide; Pentylenetetrazole; Picrotoxin; Resuscitation; Strychnine; Toxicology

1963

Other Studies

8 other study(ies) available for strychnine and Coma

ArticleYear
Enhanced endogenous ornithine concentrations protect against tonic seizures and coma in acute ammonia intoxication.
    Pharmacology & toxicology, 1993, Volume: 72, Issue:2

    Pretreatment of mice with 5-fluoromethylornithine (5FMOrn), a selective inactivator of ornithine aminotransferase, diminishes the accumulation of ammonia in the brain after administration of ammonium acetate, and antagonizes ammonia-induced fatal tonic extensor convulsions. In about 50% of the treated animals the loss of the righting reflex and coma is prevented. Presumably these effects are based on the enhancement of urea formation by the increased liver ornithine concentrations. However, since brain ornithine concentrations are greatly enhanced by 5FMOrn, it is not excluded that ornithine has direct effects on cellular events involved in ammonia-induced seizure generation, even though 5FMOrn had no anticonvulsant properties in a series of established animal seizure models, including N-methyl-D,L-aspartate-induced convulsions. NMDA receptor antagonists are capable of preventing death, but do not protect against the generation of coma and tonic extensor convulsions in ammonium acetate intoxicated mice. Since no evidence was found for ammonia-induced glutamate release from rat hippocampus, there is no convincing evidence for the idea that the tonic convulsions are mediated by NMDA receptors. L-Methionine-D, L-sulfoximine (MSO)-induced seizures can be partially antagonized by pretreatment with 5FMOrn. However, the effect is considerably smaller than against ammonia-induced convulsions, although at the time of seizure onset brain ammonia levels of MSO-intoxicated mice were lower than in the animals receiving ammonium acetate. This suggests that MSO-convulsions are not entirely due to the elevation of brain ammonia concentrations, even though MSO administration mimics effects of ammonia on cortical inhibitory neuronal interactions.(ABSTRACT TRUNCATED AT 250 WORDS)

    Topics: 3-Mercaptopropionic Acid; Ammonia; Animals; Brain Chemistry; Coma; Dialysis; Dizocilpine Maleate; Electroshock; Epilepsy, Generalized; Female; Glutamate-Ammonia Ligase; Methionine Sulfoximine; Mice; N-Methylaspartate; Ornithine; Ornithine-Oxo-Acid Transaminase; Pentylenetetrazole; Postural Balance; Putrescine; Strychnine

1993
[Efficacy of the use of strychnine in barbiturate coma].
    Vrachebnoe delo, 1969, Volume: 9

    Topics: Adult; Antidotes; Barbiturates; Coma; Female; Humans; Strychnine

1969
[Massive doses of strychnine in the treatment of barbituate coma].
    Sveikatos apsauga, 1962, Volume: 7

    Topics: Barbiturates; Coma; Strophanthins; Strychnine

1962
[Treatment of barbituric coma with large doses of strychnine].
    Suvremenna meditsina, 1956, Volume: 7, Issue:10

    Topics: Ascomycota; Barbiturates; Coma; Humans; Strychnine

1956
[Very severe barbiturate coma cured by mixed treatment: strychnine (95 centigrams) and picrotoxin (2,000 milligrams)].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1951, Mar-10, Volume: 27, Issue:19

    Topics: Ascomycota; Barbital; Barbiturates; Coma; Picrotoxin; Strychnine

1951
Serious barbiturate coma cured by association, para-1-amino-2-phenyl-propane-dextrorotatory strychninetartrate.
    Algerie medicale, 1949, Volume: 53, Issue:3

    Topics: Barbital; Barbiturates; Coma; Strychnine

1949
Strychnine and wakefulness amines in the treatment of barbiturate coma.
    La Presse medicale, 1949, Jun-04, Volume: 57, Issue:37

    Topics: Amines; Barbital; Barbiturates; Coma; Strychnine

1949
Barbiturate coma complicated by acute pneumonia; therapeutic association, strychnine and penicillin.
    Bulletin mensuel - Societe de medecine militaire francaise, 1948, Volume: 42, Issue:3

    Topics: Ascomycota; Barbital; Coma; Penicillins; Strychnine

1948